MGR13
MCID: MGR042
MIFTS: 17

Migraine with or Without Aura 13 (MGR13)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Migraine with or Without Aura 13

MalaCards integrated aliases for Migraine with or Without Aura 13:

Name: Migraine with or Without Aura 13 57 72
Migraine, with or Without Aura 13 57 29 6
Migraine, with or Without Aura, Susceptibility to, 13 57 13
Mgr13 57 72
Migraine with or Without Aura, Susceptibility to, 13 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset early teens
migraine triggers include tiredness, alcohol consumption, and bright lights
headache duration 24-48 hours


HPO:

31
migraine with or without aura 13:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 613656
OMIM Phenotypic Series 57 PS157300
MedGen 41 C3150908
SNOMED-CT via HPO 68 263681008 4473006 56097005

Summaries for Migraine with or Without Aura 13

UniProtKB/Swiss-Prot : 72 Migraine with or without aura 13: A form of migraine transmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.

MalaCards based summary : Migraine with or Without Aura 13, also known as migraine, with or without aura 13, is related to migraine with or without aura 1. An important gene associated with Migraine with or Without Aura 13 is KCNK18 (Potassium Two Pore Domain Channel Subfamily K Member 18). Related phenotypes are migraine with aura and migraine without aura

More information from OMIM: 613656 PS157300

Related Diseases for Migraine with or Without Aura 13

Diseases in the Migraine Without Aura family:

Migraine with or Without Aura 1 Migraine with or Without Aura 2
Migraine with or Without Aura 3 Migraine Without Aura 4
Migraine with or Without Aura 5 Migraine with or Without Aura 6
Migraine with or Without Aura 8 Migraine with or Without Aura 10
Migraine with or Without Aura 11 Migraine with or Without Aura 12
Migraine with or Without Aura 13

Diseases related to Migraine with or Without Aura 13 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 11.0

Symptoms & Phenotypes for Migraine with or Without Aura 13

Human phenotypes related to Migraine with or Without Aura 13:

31
# Description HPO Frequency HPO Source Accession
1 migraine with aura 31 HP:0002077
2 migraine without aura 31 HP:0002083

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Neurologic Central Nervous System:
photophobia
phonophobia
migraine headache with or without visual aura
lateralized or holocranial headache
osmophobia

Abdomen Gastrointestinal:
vomiting
nausea

Clinical features from OMIM®:

613656 (Updated 05-Apr-2021)

Drugs & Therapeutics for Migraine with or Without Aura 13

Search Clinical Trials , NIH Clinical Center for Migraine with or Without Aura 13

Genetic Tests for Migraine with or Without Aura 13

Genetic tests related to Migraine with or Without Aura 13:

# Genetic test Affiliating Genes
1 Migraine, with or Without Aura 13 29 KCNK18

Anatomical Context for Migraine with or Without Aura 13

Publications for Migraine with or Without Aura 13

Articles related to Migraine with or Without Aura 13:

# Title Authors PMID Year
1
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. 6 57
20871611 2010

Variations for Migraine with or Without Aura 13

ClinVar genetic disease variations for Migraine with or Without Aura 13:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 KCNK18 NM_181840.1(KCNK18):c.361dup (p.Tyr121fs) Duplication Likely pathogenic 225399 rs541915908 GRCh37: 10:118969015-118969016
GRCh38: 10:117209504-117209505
2 KCNK18 NM_181840.1(KCNK18):c.410_411CT[2] (p.Phe139fs) Microsatellite risk factor 18398 rs869025175 GRCh37: 10:118969065-118969066
GRCh38: 10:117209554-117209555

Expression for Migraine with or Without Aura 13

Search GEO for disease gene expression data for Migraine with or Without Aura 13.

Pathways for Migraine with or Without Aura 13

GO Terms for Migraine with or Without Aura 13

Sources for Migraine with or Without Aura 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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