MCID: MGR001
MIFTS: 48

Migraine Without Aura

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Migraine Without Aura

MalaCards integrated aliases for Migraine Without Aura:

Name: Migraine Without Aura 12 44 15
Common Migraine 12 55 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12783
ICD10 33 G43.0 G43.009
ICD9CM 35 346.1
MeSH 44 D020326
NCIt 50 C117004
SNOMED-CT 68 56097005
UMLS 73 C0338480

Summaries for Migraine Without Aura

Disease Ontology : 12 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards based summary : Migraine Without Aura, also known as common migraine, is related to migraine with or without aura 1 and headache. An important gene associated with Migraine Without Aura is MGR4 (Migraine, Susceptibility To, 4), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Milnacipran and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and bone, and related phenotypes are behavior/neurological and integument

Related Diseases for Migraine Without Aura

Diseases in the Migraine Without Aura family:

Migraine with or Without Aura 1 Migraine with or Without Aura 2
Migraine with or Without Aura 3 Migraine Without Aura 4
Migraine with or Without Aura 5 Migraine with or Without Aura 6
Migraine with or Without Aura 8 Migraine with or Without Aura 10
Migraine with or Without Aura 11 Migraine with or Without Aura 12
Migraine with or Without Aura 13

Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 31.1 ATP1A2 CACNA1A DRD2 DRD3 DRD4 HTR1A
2 headache 30.9 ATP1A2 CACNA1A SCN1A
3 cluster headache 30.2 CACNA1A PRL
4 migraine with aura 30.2 ATP1A2 CACNA1A DRD2 KCNK18 MTHFR SCN1A
5 alexithymia 30.0 DRD2 HTR1A SLC6A4
6 hemiplegic migraine 29.3 ATP1A2 CACNA1A SCN1A
7 familial hemiplegic migraine 29.3 ATP1A2 CACNA1A SCN1A
8 bipolar disorder 28.7 DRD2 DRD3 DRD4 HTR1A MTHFR PRL
9 migraine without aura 4 12.4
10 migraine, familial hemiplegic, 3 11.3
11 migraine with or without aura 13 11.3
12 carotidynia 10.9
13 tic disorder 10.3 DRD2 DRD4
14 polysubstance abuse 10.2 DRD2 DRD3
15 tardive dyskinesia 10.2 DRD2 DRD3
16 heroin dependence 10.2 DRD2 DRD4
17 endometriosis 10.2
18 depression 10.2
19 alcohol-induced mental disorder 10.2 DRD2 SLC6A4
20 substance-induced psychosis 10.1 DRD2 HTR1A
21 delusional disorder 10.1 DRD2 DRD3 DRD4
22 impulse control disorder 10.1 DRD2 DRD3 DRD4
23 alcoholic psychosis 10.1 DRD2 SLC6A4
24 torticollis 10.1 CACNA1A DRD2
25 galactorrhea 10.1 DRD2 PRL
26 schizophreniform disorder 10.1 DRD2 PRL
27 prolactin producing pituitary tumor 10.1 DRD2 PRL
28 drug-induced mental disorder 10.1 DRD2 HTR1A
29 orofacial cleft 10.1 DRD2 DRD4 MTHFR
30 drug psychosis 10.1 DRD2 HTR1A
31 opiate dependence 10.1 DRD2 DRD3 SLC6A4
32 oppositional defiant disorder 10.1 DRD2 DRD4 SLC6A4
33 cocaine dependence 10.1 DRD2 DRD3 SLC6A4
34 peripartum cardiomyopathy 10.1 DRD2 PRL
35 drug dependence 10.1 DRD2 DRD3 SLC6A4
36 conduct disorder 10.1 DRD2 DRD4 SLC6A4
37 psychosexual disorder 10.1 HTR1A SLC6A4
38 neuroleptic malignant syndrome 10.1 DRD2 HTR1A
39 phobic disorder 10.0 HTR1A SLC6A4
40 restless legs syndrome 10.0 CACNA1A DRD2 DRD3
41 kleptomania 10.0 HTR1A SLC6A4
42 functioning pituitary adenoma 10.0 DRD2 PRL
43 premature ejaculation 10.0 HTR1A SLC6A4
44 neurofibromatosis, type i 10.0
45 helicobacter pylori infection 10.0
46 fibrous dysplasia 10.0
47 pertussis 10.0
48 patent foramen ovale 10.0
49 panic disorder 10.0
50 premenstrual tension 10.0

Comorbidity relations with Migraine Without Aura via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to Migraine Without Aura

Symptoms & Phenotypes for Migraine Without Aura

MGI Mouse Phenotypes related to Migraine Without Aura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 ATP1A2 CACNA1A DRD2 DRD3 DRD4 HTR1A
2 integument MP:0010771 9.5 ASTN2 ATP1A2 CACNA1A DRD2 MTHFR PRL
3 nervous system MP:0003631 9.36 ATP1A2 CACNA1A DRD2 DRD3 DRD4 HTR1A

Drugs & Therapeutics for Migraine Without Aura

Drugs for Migraine Without Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
2
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
3
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Almotriptan Approved, Investigational Phase 4,Not Applicable 154323-57-6, 181183-52-8 123606
6
Topiramate Approved Phase 4,Phase 3,Phase 2,Not Applicable 97240-79-4 5284627
7
Diphenhydramine Approved, Investigational Phase 4,Phase 3 147-24-0, 58-73-1 3100
8
Haloperidol Approved Phase 4 52-86-8 3559
9
Promethazine Approved, Investigational Phase 4,Phase 3 60-87-7 4927
10
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-45-6, 75614-87-8 774
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12 Psychotropic Drugs Phase 4,Phase 2
13 Serotonin Agents Phase 4,Phase 3,Not Applicable
14 Antidepressive Agents Phase 4
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Adrenergic Agents Phase 4,Phase 2,Phase 3
17 Neurotransmitter Uptake Inhibitors Phase 4
18 Serotonin Uptake Inhibitors Phase 4
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Dopamine D2 Receptor Antagonists Phase 4
21 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
22 Ketorolac Tromethamine Phase 4
23 Dopamine Antagonists Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Not Applicable
25 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
26 Dopamine Agents Phase 4
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
30 Antiemetics Phase 4,Phase 3,Phase 1,Phase 2
31 Cyclooxygenase Inhibitors Phase 4,Phase 3,Not Applicable
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Anti-Obesity Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
36 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
38 Anti-Allergic Agents Phase 4,Phase 3
39 Antipsychotic Agents Phase 4
40 Dermatologic Agents Phase 4,Phase 3
41 Haloperidol decanoate Phase 4
42 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
43 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44
Histamine Phosphate Phase 4,Phase 3,Not Applicable 51-74-1 65513
45 Tranquilizing Agents Phase 4
46 decanoic acid Phase 4
47 Histamine Antagonists Phase 4,Phase 3,Not Applicable
48 Hypnotics and Sedatives Phase 4,Phase 3
49 Histamine H1 Antagonists Phase 4,Phase 3,Not Applicable
50 Antipruritics Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4 milnacipran
2 Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department Completed NCT01596166 Phase 4 Ketorolac Tromethamine;Metoclopramide
3 Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine Completed NCT00210496 Phase 4 topiramate; almotriptan malate
4 Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. Completed NCT00212810 Phase 4 Topiramate
5 Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial Completed NCT02098499 Phase 4 Haloperidol;Metoclopramide 10mg;Diphenhydramine
6 Intravenous Metoclopramide in the Acute Treatment of Migraine: A Double-blind, Randomized, Placebo-controlled Trial Completed NCT02314351 Phase 4 Metoclopramide 10 mg;Placebo;Fentanyl
7 Acupuncture for Migraine Prophylaxis Unknown status NCT01687660 Phase 2, Phase 3
8 Dysport® In Migraine Without Aura Prophylaxis : DIMWAP Study Completed NCT00258609 Phase 3 Botulinum Toxin type A (Dysport ® ) IM/SC 6-sites pericranial injection
9 Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment Completed NCT01814189 Phase 3 Sumatriptan+Promethazine (SPr)
10 Evaluation of the Efficacy and Safety of Laxymig® as Prophylactic Treatment in Patients With Migraine Completed NCT00334178 Phase 3 Laxymig ER (drug)
11 Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study Completed NCT01859481 Phase 3 Placebo;Eletriptan HBr 40 mg;Eletriptan HBr 80 mg
12 Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache Completed NCT00471952 Phase 3 Maxalt 10mg MLT plus Caffeine 75mg;Maxalt 10mg MLT plus Placebo;Placebo + Placebo
13 TREXIMET (Formerly Known as TREXIMA) for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1) Completed NCT00387881 Phase 3 sumatriptan succinate / naproxen sodium;Placebo
14 Candesartan Versus Propranolol for Migraine Prevention Completed NCT00884663 Phase 2, Phase 3 Candesartan;propranolol;placebo
15 A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine Completed NCT00236509 Phase 3 topiramate
16 A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine Completed NCT00236561 Phase 3 topiramate, propranolol
17 A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine Completed NCT00231595 Phase 3 topiramate
18 Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines Completed NCT00122278 Phase 3 Dexamethasone
19 Oral ALLOD-2 vs. Its Components & vs. Placebo in the Acute Treatment of Migraine (ANODYNE-1) Completed NCT03061734 Phase 2, Phase 3 ALLOD-2;ALLOD-2H;Component A (regular dose);Component B;Placebo
20 Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention Completed NCT02456740 Phase 3 Erenumab;Placebo
21 Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) Compared to Placebo in Migraine Prevention Completed NCT02483585 Phase 3 Erenumab;Placebo
22 Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine Unknown status NCT00285402 Phase 2 AST-726 Low dose;AST-726 High dose;AST-726 Placebo
23 Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura Completed NCT00959751 Phase 2 NXN-188;Placebo
24 Dose Ranging Study of the Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache Completed NCT00534560 Phase 2 Tonabersat;Tonabersat;Placebo
25 Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache Completed NCT00311662 Phase 2 Tonabersat;Placebo
26 Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache Completed NCT00123201 Phase 2 Dronabinol MDI
27 Botox Injection in Treatment of Chronic Migraine Completed NCT02259075 Phase 1, Phase 2 Botulinum Toxin Type A
28 Continuous Treatment Study of Topiramate in Migraine Participants Completed NCT01799590 Phase 2 Topiramate
29 A Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Chronic Migraine Prevention Completed NCT02066415 Phase 2 Placebo
30 A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine Completed NCT01081795 Phase 2 Topiramate;Placebo
31 A Study to Assess the Long-term Safety and Efficacy of Erenumab (AMG 334) in Chronic Migraine Prevention. Completed NCT02174861 Phase 2 Erenumab
32 Efficacy and Safety Study of E2007 in Migraine Prophylaxis Completed NCT00154063 Phase 2 E2007
33 Can DFN-15 Terminate Migraine With Allodynia? Recruiting NCT03472378 Phase 2 DFN-15
34 Treatment of Chronic Migraine Headaches. Recruiting NCT03220113 Phase 1, Phase 2
35 A Phase 2 Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention Active, not recruiting NCT01952574 Phase 2 Erenumab;Placebo
36 A Study of a Melatonin Receptor Agonist to Prevent Migraine Terminated NCT00739024 Phase 2 Ramelteon;Placebo
37 MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular Interaction Unknown status NCT01803984
38 Investigation of the Blood-brain and Blood-dura Barrier Durin Migraine Attacks Using MRI Unknown status NCT02202486
39 Cortical Reorganisation in Patients With Primary Headache Disorders Unknown status NCT00263991
40 A TMU/NIH Integrated Research Project Translation of Basic Research to Clinical Diagnosis and Treatment of Mild Traumatic Brain Injury (mTBI) Unknown status NCT01266356
41 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
42 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
43 PACAP27 Headache Properties in Migraine Without Aura Patients Completed NCT03471039 Not Applicable PACAP27;Saline
44 Functional MRI (fMRI) in CGRP Induced Migraine Completed NCT00363532 Not Applicable infusion of calcitonin gene related peptide (CGRP)
45 Effect of PACAP38/VIP on Migraineurs Measured by Magnetic Resonance Completed NCT01471990 Not Applicable Pituitary Adenylate Cyclase-Activating Polypeptide-38;Vasoactive Intestinal Peptide
46 Investigation of Serotonin Receptor Binding in the Migraine Brain Using Positron Emission Tomography Completed NCT02309606
47 PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load Completed NCT02158221 Not Applicable PACAP
48 CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load Completed NCT01924052 Not Applicable CGRP
49 The Effect of Histamine H1 Receptor Antagonist, Clemastin, on PACAP38 Induced Headache in Migraine Patients Completed NCT02364453 Not Applicable PACAP38
50 PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow Completed NCT00380263 Not Applicable PACAP38

Search NIH Clinical Center for Migraine Without Aura

Cochrane evidence based reviews: migraine without aura

Genetic Tests for Migraine Without Aura

Anatomical Context for Migraine Without Aura

MalaCards organs/tissues related to Migraine Without Aura:

41
Pituitary, Brain, Bone, Cortex, Monocytes, Heart, Endothelial

Publications for Migraine Without Aura

Articles related to Migraine Without Aura:

(show top 50) (show all 316)
# Title Authors Year
1
Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura. ( 29540069 )
2018
2
Prospective memory is dysfunctional in migraine without aura. ( 29411639 )
2018
3
Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study. ( 29808331 )
2018
4
Right-to-left shunt may be prone to affect the white matter integrity of posterior circulation in migraine without aura. ( 29063453 )
2018
5
Using a Genetic Risk Score Approach to Predict Headache Response to Triptans in Migraine Without Aura. ( 30256423 )
2018
6
Acupuncture for migraine without aura: a systematic review and meta-analysis. ( 30007828 )
2018
7
Postural instability during attacks of migraine without aura. ( 30295375 )
2018
8
Comparison of Parametric and Non-parametric EEG Feature Extraction Methods in Detection of Pediatric Migraine without Aura. ( 30320034 )
2018
9
Selective attention network impairment during the interictal period of migraine without aura. ( 30327224 )
2018
10
Altered speech with migraine attacks: A prospective, longitudinal study of episodic migraine without aura. ( 30449150 )
2018
11
Visual Field Losses in Patients with Migraine without Aura and Tension-Type Headache. ( 28348627 )
2017
12
Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study. ( 28853611 )
2017
13
Abnormal functional integration across core brain networks in migraine without aura. ( 28969471 )
2017
14
The power features of Masseter muscle activity in tension-type and migraine without aura headache during open-close clench cycles. ( 28775915 )
2017
15
Raven coloured progressive matrices in migraine without aura patients. ( 28527091 )
2017
16
RE: Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. ( 29105529 )
2017
17
Correction to: Albury et al., RE: Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. ( 29148276 )
2017
18
Cardiovascular risk factors and white matter hyperintensities in patients with migraine without aura. ( 29171645 )
2017
19
Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study. ( 28701932 )
2017
20
Acupuncture modulates the abnormal brainstem activity in migraine without aura patients. ( 28580293 )
2017
21
Intact blood-brain barrier during spontaneous attacks of migraine without aura: a 3T DCE-MRI study. ( 28727225 )
2017
22
Response from Original Authors - RE: Six novel rare nonsynonymous mutations for migraine without aura identified by exome sequencing. ( 29037100 )
2017
23
Visual-spatial training efficacy in children affected by migraine without aura: a multicenter study. ( 28184165 )
2017
24
Acquired equivalence and related memory processes in migraine without aura. ( 27206960 )
2017
25
An Arterial Spin Labeling MRI Perfusion Study of Migraine without Aura Attacks. ( 28701991 )
2017
26
Headache Attributed to Fibrous Dysplasia of the Ethmoid Bone Mimicking Menstrual Migraine Without Aura. ( 27213743 )
2016
27
Study of sleep microstructure in patients of migraine without aura. ( 26041648 )
2016
28
Warfarin prophylaxis in migraine without aura but not in primary exercise headache. ( 26292927 )
2016
29
Lateral inhibition in the somatosensory cortex during and between migraine without aura attacks: Correlations with thalamocortical activity and clinical features. ( 26442930 )
2016
30
Memantine for Prophylactic Treatment of Migraine Without Aura: A Randomized Double-Blind Placebo-Controlled Study. ( 26638119 )
2016
31
Altered resting-state ascending/descending pathways associated with the posterior thalamus in migraine without aura. ( 26825347 )
2016
32
Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population. ( 27326362 )
2016
33
Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study. ( 27568039 )
2016
34
Discriminative Analysis of Migraine without Aura: Using Functional and Structural MRI with a Multi-Feature Classification Approach. ( 27690138 )
2016
35
Grey zones in the diagnosis of adult migraine without aura based on the International Classification of Headache Disorders-III beta: exploring the covariates of possible migraine without aura. ( 25493966 )
2015
36
Endothelial Function in Patients with Migraine without Aura during the Interictal Period. ( 25789137 )
2015
37
P026. Pilot study on the use of coenzyme Q10 in a group of patients with episodic migraine without aura. ( 28132202 )
2015
38
Ultrasound-guided greater occipital nerve block: an efficient technique in chronic refractory migraine without aura? ( 25794201 )
2015
39
O005. Efficacy of oral supplement compared with amitriptyline in the prophylaxis of episodic tension-type headache and migraine without aura. ( 28132255 )
2015
40
The anterior insula shows heightened interictal intrinsic connectivity in migraine without aura. ( 25663219 )
2015
41
P019. Transcutaneous supraorbital neurostimulation in "de novo" patients with migraine without aura: the first Italian experience. ( 28132252 )
2015
42
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. ( 26660531 )
2015
43
Menstrual versus non-menstrual attacks of migraine without aura in women with and without menstrual migraine. ( 25754177 )
2015
44
O052. Migraine without aura and osteopathic medicine, a non-pharmacological approach to pain and quality of life: open pilot study. ( 28132208 )
2015
45
The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients. ( 25916336 )
2015
46
Transcutaneous supraorbital neurostimulation in "de novo" patients with migraine without aura: the first Italian experience. ( 26197977 )
2015
47
MicroRNA profiling in migraine without aura: pilot study. ( 26333279 )
2015
48
Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. ( 26814133 )
2015
49
Elevated audiovisual temporal interaction in patients with migraine without aura. ( 24961903 )
2014
50
Thickening of the somatosensory cortex in migraine without aura. ( 24728304 )
2014

Variations for Migraine Without Aura

Expression for Migraine Without Aura

Search GEO for disease gene expression data for Migraine Without Aura.

Pathways for Migraine Without Aura

Pathways related to Migraine Without Aura according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 CACNA1A DRD2 DRD3 DRD4 SCN1A
2
Show member pathways
12.48 CACNA1A DRD2 DRD3 DRD4
3
Show member pathways
11.98 ATP1A2 DRD2 HTR1A
4 11.81 CACNA1A DRD2 DRD3 DRD4
5 11.6 CACNA1A HTR1A SLC6A4
7
Show member pathways
11.56 ATP1A2 CACNA1A SLC6A4
8
Show member pathways
11.44 DRD2 DRD3 DRD4
9
Show member pathways
10.98 DRD2 DRD3 DRD4 HTR1A
10 10.9 HTR1A SLC6A4
11 10.78 DRD2 DRD3

GO Terms for Migraine Without Aura

Cellular components related to Migraine Without Aura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.96 ASTN2 ATP1A2 CACNA1A DRD2 DRD3 DRD4
2 dendrite GO:0030425 9.46 CACNA1A DRD2 DRD4 HTR1A
3 integral component of plasma membrane GO:0005887 9.43 DRD2 DRD3 DRD4 HTR1A KCNK18 SLC6A4
4 dopaminergic synapse GO:0098691 8.62 DRD2 DRD3

Biological processes related to Migraine Without Aura according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.83 DRD2 MTHFR SLC6A4
2 response to drug GO:0042493 9.83 DRD2 DRD3 MTHFR PRL SLC6A4
3 response to ethanol GO:0045471 9.81 DRD2 DRD3 PRL
4 social behavior GO:0035176 9.75 DRD3 DRD4 SLC6A4
5 visual learning GO:0008542 9.73 ATP1A2 DRD2 DRD3
6 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.67 DRD4 HTR1A
7 behavioral fear response GO:0001662 9.67 DRD4 HTR1A
8 response to morphine GO:0043278 9.67 DRD2 DRD3
9 negative regulation of blood pressure GO:0045776 9.66 DRD2 DRD3
10 regulation of multicellular organism growth GO:0040014 9.66 DRD3 PRL
11 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.65 DRD2 DRD3
12 synaptic transmission, dopaminergic GO:0001963 9.65 DRD2 DRD3
13 response to amphetamine GO:0001975 9.65 DRD2 DRD3 DRD4
14 vasoconstriction GO:0042310 9.64 HTR1A SLC6A4
15 prepulse inhibition GO:0060134 9.63 DRD2 DRD3
16 positive regulation of renal sodium excretion GO:0035815 9.63 DRD2 DRD3
17 adult walking behavior GO:0007628 9.63 CACNA1A DRD2 SCN1A
18 G protein-coupled receptor internalization GO:0002031 9.62 DRD2 DRD3
19 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.62 DRD3 DRD4
20 negative regulation of cytosolic calcium ion concentration GO:0051481 9.61 ATP1A2 DRD2
21 regulation of dopamine metabolic process GO:0042053 9.61 DRD4 HTR1A
22 behavioral response to ethanol GO:0048149 9.6 DRD2 DRD4
23 negative regulation of voltage-gated calcium channel activity GO:1901386 9.59 DRD2 DRD4
24 neuron-neuron synaptic transmission GO:0007270 9.58 CACNA1A DRD2
25 arachidonic acid secretion GO:0050482 9.58 DRD2 DRD3 DRD4
26 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.57 DRD2 DRD3
27 negative regulation of dopamine receptor signaling pathway GO:0060160 9.55 DRD2 DRD3
28 acid secretion GO:0046717 9.54 DRD2 DRD3
29 behavioral response to cocaine GO:0048148 9.54 DRD2 DRD3 DRD4
30 musculoskeletal movement, spinal reflex action GO:0050883 9.52 CACNA1A DRD3
31 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.51 DRD2 DRD4
32 dopamine receptor signaling pathway GO:0007212 9.5 DRD2 DRD3 DRD4
33 regulation of locomotion involved in locomotory behavior GO:0090325 9.49 DRD2 DRD3
34 negative regulation of protein secretion GO:0050709 9.43 DRD2 DRD3 DRD4
35 dopamine metabolic process GO:0042417 9.33 DRD2 DRD3 DRD4
36 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.13 DRD2 DRD3 DRD4
37 response to histamine GO:0034776 8.8 DRD2 DRD3 DRD4

Molecular functions related to Migraine Without Aura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.56 ATP1A2 DRD2 DRD3 DRD4
2 G protein-coupled serotonin receptor activity GO:0004993 9.4 DRD4 HTR1A
3 adrenergic receptor activity GO:0004935 9.37 DRD2 DRD3
4 dopamine binding GO:0035240 9.33 DRD2 DRD3 DRD4
5 serotonin binding GO:0051378 9.32 HTR1A SLC6A4
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.13 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD2 DRD3 DRD4

Sources for Migraine Without Aura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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