Mikulicz Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ IgG4-related dacryoadenitis and sialoadenitis (formerly called Mikulicz disease) is an IgG4-related disease characterized by inflammation of the lacrimal glands (which produce tears), parotid glands, and submandibular glands (two of the major salivary glands). In some cases, it also affects other glands or organs. The condition is usually painless, mainly causing mouth and eye dryness, and swelling over the affected glands. When other organs are affected, it can be accompanied by complications such as autoimmune pancreatitis, retroperitoneal fibrosis, and tubulointerstitial nephritis. The underlying cause of IgG4-related disease is still not known.

MalaCards based summary: Mikulicz Disease, also known as igg4-related dacryoadenitis and sialadenitis, is related to thyroiditis and chronic rhinitis, and has symptoms including lumps of the face An important gene associated with Mikulicz Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, liver and bone, and related phenotypes are enlarged lacrimal glands and abnormality of the submandibular glands

Orphanet: ⁵⁸ IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease (see this term) characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis (see these terms).

Disease Ontology: ¹¹ An autoimmune disease that is characterized by chronic enlargement of the glands of the head and neck, has symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection.

Wikipedia: ⁷⁵ Benign lymphoepithelial lesion or Mikulicz' disease is a type of benign enlargement of the parotid... more...

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Related Diseases for Mikulicz Disease

Diseases related to Mikulicz Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 657)

#	Related Disease	Score	Top Affiliating Genes
1	thyroiditis	30.4	IL4 IL10 CRP
2	chronic rhinitis	30.1	IL5 IL4 IL13
3	bell's palsy	30.0	CRP CD4
4	interstitial nephritis	29.9	ICOSLG CRP CD4 CCR6
5	cholangitis	29.9	IL10 CRP CA2
6	erythema nodosum	29.8	IL13 IL10 CRP
7	keratoconjunctivitis	29.8	TRIM21 IL5 IL4 IL13
8	hypereosinophilic syndrome	29.8	IL5 IL4 IL13 IL10
9	allergic rhinitis	29.8	IL5 IL4 IL13 IL10
10	aplastic anemia	29.7	IL4 IL10 CD4 CCR6
11	juvenile rheumatoid arthritis	29.7	ICOSLG CRP CD4 CCR6
12	sarcoidosis 1	29.7	IL13 IL10 ICOSLG CRP CD4 CCR6
13	lymphadenitis	29.7	IL10 ICOSLG CRP CCR6
14	acquired immunodeficiency syndrome	29.7	IL10 CRP CD4
15	multicentric castleman disease	29.6	IL10 CRP CD4 CCR6
16	castleman disease	29.6	IL10 CRP CD4 CCR6
17	miliary tuberculosis	29.6	IL4 IL10 CRP CD4
18	rhinitis	29.6	IL5 IL4 IL13 IL10 ICOSLG
19	lymphoma, hodgkin, classic	29.5	TNFSF13B IL13 ICOSLG CCR6
20	vasculitis	29.5	TNFSF13B IL10 CRP
21	purpura	29.5	TNFSF13B IL4 IL10 CRP
22	mantle cell lymphoma	29.5	TNFSF13B ICOSLG CD4 CCR6
23	lymphoma, mucosa-associated lymphoid type	29.5	TNFSF13B ICOSLG CD4 CCR6
24	pancreatitis	29.4	SPINK1 IL10 CRP CA2
25	sclerosing cholangitis	29.4	IL10 ICOSLG CRP CD4 CCR6
26	bronchiolitis	29.4	IL5 IL4 IL13 IL10 CRP
27	mononeuropathy	29.3	TRIM21 SSB CRP CD4
28	dacryoadenitis	29.2	TRIM21 TNFSF13B SSB IL4 IL13 IL10
29	cholangitis, primary sclerosing	29.2	IL4 IL10 ICOSLG CRP CD4 CCR6
30	thrombocytopenia due to platelet alloimmunization	29.2	TNFSF13B IL10 ICOSLG CD4 CCR6
31	leukemia, chronic lymphocytic	29.2	TNFSF13B IL4 IL10 ICOSLG CD4 CCR6
32	parotitis	29.1	TRIM21 SSB SPINK1 CRP CD4
33	sjogren syndrome	29.1	TRIM21 TNFSF13B SSB IL10 ICOSLG CCR6
34	mononeuritis multiplex	29.1	TRIM21 SSB IL5 CRP CD4
35	thrombocytopenia	28.9	TRIM21 TNFSF13B IL4 IL10 CRP CD4
36	exanthem	28.9	TRIM21 IL4 IL10 ICOSLG CRP CD4
37	autoimmune pancreatitis	28.8	SPINK1 IL10 ICOSLG CRP CD4 CCR6
38	polyclonal hypergammaglobulinemia	28.8	TRIM21 TNFSF13B ICOSLG CRP CD4 CCR6
39	common cold	28.7	IL5 IL4 IL13 IL10 ICOSLG CRP
40	sialadenitis	28.7	TRIM21 TNFSF13B SSB IL13 ICOSLG CD4
41	xerophthalmia	28.7	TRIM21 TNFSF13B SSB ICOSLG CRP CD4
42	keratoconjunctivitis sicca	28.5	TRIM21 TNFSF13B SSB IL4 ICOSLG CD4
43	autoimmune disease	28.4	TRIM21 TNFSF13B IL5 IL4 IL13 IL10
44	immune deficiency disease	28.3	TNFSF13B IL4 IL13 IL10 ICOSLG CRP
45	igg4-related disease	28.3	TNFSF13B IL5 IL4 IL13 IL10 ICOSLG
46	asthma	28.1	TNFSF13B IL5 IL4 IL13 IL10 ICOSLG
47	salivary gland disease	27.8	TRIM21 TNFSF13B SSB IL4 IL10 ICOSLG
48	connective tissue disease	27.8	TRIM21 TNFSF13B IL5 IL4 IL13 IL10
49	enterobiasis	10.3	IL5 IL4
50	aztreonam allergy	10.3	IL5 IL13

Graphical network of the top 20 diseases related to Mikulicz Disease:

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Symptoms & Phenotypes for Mikulicz Disease

Human phenotypes related to Mikulicz Disease:

⁵⁸ ³⁰ (show all 33)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	enlarged lacrimal glands ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0007734
2	abnormality of the submandibular glands ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0010287
3	increased circulating igg4 level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0032300
4	enlargement of parotid gland ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0011801
5	fatigue ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012378
6	fever ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001945
7	palpebral edema ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100540
8	proptosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000520
9	weight loss ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001824
10	keratoconjunctivitis sicca ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001097
11	generalized muscle weakness ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003324
12	myositis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100614
13	xerostomia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000217
14	increased circulating iga level ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003261
15	increased circulating igm level ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003496
16	periorbital fullness ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000629
17	antinuclear antibody positivity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003493
18	abnormality of the extraocular muscles ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0008049
19	cytoplasmic antineutrophil antibody positivity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0032230
20	blindness ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000618
21	thyroiditis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100646
22	thrombocytopenia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001873
23	abnormal lacrimal duct morphology ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0011481
24	lymphadenopathy ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002716
25	tubulointerstitial nephritis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001970
26	optic nerve compression ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0007807
27	retroperitoneal fibrosis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0005200
28	nodular goiter ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0005994
29	autoimmunity ⁵⁸		Occasional (29-5%)
30	abnormal salivary gland morphology ⁵⁸		Very frequent (99-80%)
31	abnormality of the optic nerve ⁵⁸		Occasional (29-5%)
32	facial edema ⁵⁸		Occasional (29-5%)
33	abnormality of the orbital region ⁵⁸		Occasional (29-5%)

Symptoms:

¹¹

• lumps of the face

MGI Mouse Phenotypes related to Mikulicz Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	CA2 CCR6 CD4 CRP ICOSLG IL10
2	immune system	MP:0005387	9.77	CA2 CCR6 CD4 CRP ICOSLG IL10
3	digestive/alimentary	MP:0005381	9.7	CA2 CD4 IL10 IL13 IL4 IL5
4	hematopoietic system	MP:0005397	9.36	CCR6 CD4 ICOSLG IL10 IL13 IL4

Sources

Drugs & Therapeutics for Mikulicz Disease

Search Clinical Trials, NIH Clinical Center for Mikulicz Disease

Cochrane evidence based reviews: mikulicz' disease

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Genetic Tests for Mikulicz Disease

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Anatomical Context for Mikulicz Disease

Organs/tissues related to Mikulicz Disease:

MalaCards : Eye, Liver, Bone, Salivary Gland, T Cells, Bone Marrow, Lung

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Publications for Mikulicz Disease

Articles related to Mikulicz Disease:

(show top 50) (show all 347)

#	Title	Authors	PMID	Year
1	Thoracic manifestations of IgG4-related disease. ⁶²	Muller R...Schleinitz N	36437514	2022
2	Treatment outcomes and their determinants of IgG4-related ophthalmic disease: a territory-wide cohort study. ⁶²	Lai KKH...Chong KKL	36288914	2022
3	Ultrasonography of IgG4-related dacryoadenitis and sialadenitis: Imaging features and clinical usefulness. ⁶²	Komori T...Gabata T	34918161	2022
4	Clinical characteristics and therapeutic response of immunoglobulin G4-related disease: a retrospective study of 127 Chinese patients. ⁶²	An W...Jia J	35927746	2022
5	CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling. ⁶²	Chinju A...Nakamura S	34907668	2022
6	[A case of Mikulicz disease of submandibular gland]. ⁶²	Du YY...Gong L	35527446	2022
7	Cases with IgG4-related ophthalmic disease with mass lesions surrounding the optic nerve. ⁶²	Hamaoka S...Sugiyama K	35146198	2022
8	Three-dimensional ultrasonographic imaging of Mikulicz's disease. ⁶²	Suzuki A...Yoshida M	34559333	2022
9	IgG4-Related Dacryoadenitis in Egyptian Patients: A Retrospective Study. ⁶²	Salama OH...Ghanem S	36039106	2022
10	T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis. ⁶²	Ibrahem HM	35769404	2022
11	Routine IgG4 staining in minor salivary gland biopsy in a cohort of Italian Caucasian patients suffering from xerostomia. ⁶²	Conticini E...Frediani B	35645421	2022
12	Significance of high serum IgG4 in complete or non-full-fledged IgG4-related disease-a retrospective investigation of 845 patients and its clinical relevance. ⁶²	Tsai HC...Tsai CY	34455508	2022
13	[A Case of IgG4-Related Disease Arising in Female Periurethra]. ⁶²	Okuda Y...Miyagawa Y	34856791	2021
14	Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease. ⁶²	Okawa S...Kiura K	33775999	2021
15	Differences in clinical characteristics of IgG4-related disease across age groups: a prospective study of 737 patients. ⁶²	Lu H...Zeng X	33211878	2021
16	The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. ⁶²	Umehara H...Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare (MHLW) Japan.	33274670	2021
17	IgG4-related Dacryoadenitis and Sialadenitis with Palatal Gland Swelling. ⁶²	Yoshida M...Nomura T	33583876	2021
18	Increased Expression of Activation-Induced Cytidine Deaminase in Sinus Mucosa from IgG4-Related Disease Patients with Comorbid Chronic Rhinosinusitis. ⁶²	Nojima T...Mukai M	34077941	2021
19	Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis. ⁶²	Niwamoto T...Hirai T	31902317	2021
20	Immunoglobulin G4 (IgG4)-Related Sialadenitis and Dacryoadenitis With Chronic Rhinosinusitis. ⁶²	Aboulenain S...Maya JJ	32821631	2020
21	Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases. ⁶²	Peng L...Zeng X	32083541	2020
22	Pediatric Parotid Chronic Sclerosing Sialadenitis in an African-American Female: A Rare Case and Review of the Literature. ⁶²	Keidar E...Kwartowitz G	32754389	2020
23	IgG4-related disease with pseudotumor formation in the larynx. ⁶²	Matsushima K...Matsuura K	31230814	2020
24	Serum immunoglobulin G4 in Sjögren's syndrome: a pilot study. ⁶²	Maslinska M...Kwiatkowska B	32062697	2020
25	Mikulicz Disease. ⁶²	Wu C...Zeng YP	31913425	2020
26	The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. ⁶²	Sakamoto M...Nakamura S	30696319	2020
27	Genetic analysis of IgG4-related disease. ⁶²	Ishikawa Y...Terao C	31104539	2020
28	A case report of Mikulicz's disease. ⁶²	Vu DL...Nguyen MD	33598067	2020
29	Mikulicz's disease and Küttner's tumor as manifestations of IgG4-related diseases: a review of the literature. ⁶²	Kaminski B...Blochowiak K	32921832	2020
30	IgG4-related small-sized occlusive vasculitis in Mikulicz's disease. ⁶²	Ikeoka K...Hoshida S	31334401	2019
31	Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. ⁶²	Yamamoto M...Takahashi H	30354922	2019
32	Mikulicz's Disease With Immune Thrombocytopenia: A New Immunoglobulin G4-Mediated Disorder and Literature Review. ⁶²	Li S...Li F	31598602	2019
33	Sex disparities in clinical characteristics and prognosis of immunoglobulin G4-related disease: a prospective study of 403 patients. ⁶²	Wang L...Zhang W	30561747	2019
34	A case of immunoglobulin G4-related inflammatory pseudotumor mimicking renal cell carcinoma. ⁶²	Watanabe H...Tateishi U	30607433	2019
35	Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients. ⁶²	Miki M...Ogawa Y	30701685	2019
36	Immunoglobulin G4-related Disease: An Overview. ⁶²	Kawa S	33681509	2019
37	Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts. ⁶²	Wallace ZS...ACR/EULAR IgG4-RD Classification Criteria Committee	30612117	2019
38	IgG4-related respiratory disease. ⁶²	Matsui S	30474465	2019
39	Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. ⁶²	Takano K...Himi T	29656682	2019
40	Stage classification of IgG4-related dacryoadenitis and sialadenitis by the serum cytokine environment. ⁶²	Yamamoto M...Takahashi H	29385874	2018
41	Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. ⁶²	Yamamoto M...Takahashi H	30173184	2018
42	Estimation of proton density fat fraction of the salivary gland. ⁶²	Chikui T...Yoshiura K	29376736	2018
43	Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions. ⁶²	Adzavon YM...Ma X	29207199	2018
44	A case of recurrent Mikulicz's disease with mononeuritis multiplex. ⁶²	Mizuma A...Takizawa S	30799998	2018
45	Mikulicz Disease Mimicking Intraorbital Tumors. ⁶²	Murai S...Terasaka K	28987847	2018
46	Immunoglobulin G4-related ophthalmic disease. ⁶²	Yu WK...Liu CJ	29675343	2018
47	IgG4-Related Disease, the Malignancy Mimicker: Case Series from Bahrain. ⁶²	Haider M...Shah TS	30510832	2018
48	[IgG4-related disease: a case report]. ⁶²	Pineda-Galindo LF...Martinez-Solano J	29190875	2017
49	Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. ⁶²	Kamekura R...Ichimiya S	28916523	2017
50	A Case Report of Mikulicz Syndrome. ⁶²	Rao D...Sandhu SJS	29299096	2017

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Genes for Mikulicz Disease

Genes related to Mikulicz Disease (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.29	DISEASES inferred ¹⁴ ¹⁴
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	5.76	DISEASES inferred ¹⁴ ¹⁴
3	IL4	Interleukin 4	Protein Coding	5.6	DISEASES inferred ¹⁴
4	IL5	Interleukin 5	Protein Coding	5.59	DISEASES inferred ¹⁴
5	IL13	Interleukin 13	Protein Coding	5.56	DISEASES inferred ¹⁴
6	CA2	Carbonic Anhydrase 2	Protein Coding	5.47	DISEASES inferred ¹⁴
7	CD4	CD4 Molecule	Protein Coding	5.45	DISEASES inferred ¹⁴
8	IL10	Interleukin 10	Protein Coding	5.41	DISEASES inferred ¹⁴
9	TRIM21	Tripartite Motif Containing 21	Protein Coding	5.25	DISEASES inferred ¹⁴
10	CRP	C-Reactive Protein	Protein Coding	5.23	DISEASES inferred ¹⁴
11	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	5.23	DISEASES inferred ¹⁴
12	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	5.21	DISEASES inferred ¹⁴
13	SPINK1	Serine Peptidase Inhibitor Kazal Type 1	Protein Coding	5.14	DISEASES inferred ¹⁴

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Variations for Mikulicz Disease

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Expression for Mikulicz Disease

Search GEO for disease gene expression data for Mikulicz Disease.

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Pathways for Mikulicz Disease

Pathways related to Mikulicz Disease according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.73	TRIM21 TNFSF13B IL5 IL4 IL13 IL10
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.64	TNFSF13B IL5 IL4 IL13 IL10 CD4
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.46	TNFSF13B IL5 IL4 IL13 IL10 CD4
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.25	TNFSF13B IL5 IL4 IL13 IL10 CD4
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.15	CD4 IL10 IL13 IL4 IL5 TNFSF13B
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.12	TNFSF13B IL5 IL4 IL13 IL10 CD4
7	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.03	IL5 IL4 IL10 CD4
8	Neuroinflammation and glutamatergic signaling ⁷⁴	11.96	IL4 IL13 IL10
9	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.86	IL5 IL4 IL10 CD4
10	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.82	IL4 IL13 IL10
11	Allograft rejection ⁷⁴	11.73	IL5 IL4 IL13 IL10
12	Glucocorticoid receptor regulatory network ⁶¹	11.66	IL5 IL4 IL13
13	AP-1 transcription factor network ⁶¹	11.61	IL10 IL4 IL5
14	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.59	CRP ICOSLG IL10 IL4
15	Lung fibrosis ⁷⁴	11.55	IL5 IL4 IL13
16	IL4-mediated signaling events ⁶¹	11.52	IL5 IL4 IL10
17	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.44	IL5 IL4 IL13 IL10
18	THC Differentiation Pathway ⁶⁴	11.4	IL4 IL10 CD4
19	Development and heterogeneity of the ILC family ⁷⁴	11.22	IL5 IL4 IL13
20	Th2 Differentiation ⁶⁵	11.22	IL5 IL4 IL13 IL10 CD4
21	Immune infiltration in pancreatic cancer ⁷⁴	11.05	IL5 IL4 IL13 IL10
22	Innate Lymphoid Cells Differentiation ⁶⁵	11	IL5 IL4 IL13 IL10 CD4 CCR6
23	OX40 Pathway ⁶⁴	10.97	IL5 IL4 IL13 IL10
24	G-protein signaling_Rap2B regulation pathway ²²	10.88	TNFSF13B IL5 IL4 IL13 IL10
25	Cytokines and inflammatory response ⁷⁴	10.82	IL5 IL4 IL13 IL10 CD4
26	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.79	IL4 CD4
27	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.66	IL5 IL4 IL13

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GO Terms for Mikulicz Disease

Biological processes related to Mikulicz Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.32	TNFSF13B IL5 IL4 IL13 IL10 ICOSLG
2	T cell activation	GO:0042110	9.91	IL4 ICOSLG CD4
3	positive regulation of mast cell degranulation	GO:0043306	9.8	IL4 IL13
4	negative regulation of endothelial cell apoptotic process	GO:2000352	9.8	IL10 IL13 IL4
5	type 2 immune response	GO:0042092	9.76	IL4 IL10
6	regulation of isotype switching	GO:0045191	9.71	IL4 IL10
7	B cell costimulation	GO:0031296	9.67	TNFSF13B IL4
8	positive regulation of immunoglobulin production	GO:0002639	9.63	IL5 IL13 IL10
9	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.56	IL4 IL13
10	positive regulation of B cell proliferation	GO:0030890	9.56	TNFSF13B IL5 IL4 IL13
11	immune response	GO:0006955	9.4	TNFSF13B IL5 IL4 IL13 IL10 CD4

Molecular functions related to Mikulicz Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.32	TNFSF13B IL5 IL4 IL13 IL10

Sources

Sources for Mikulicz Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MKL001 MIFTS: 48	Mikulicz Disease Categories: Bone diseases, Endocrine diseases, Eye diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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