MCID: MKL001
MIFTS: 28

Mikulicz Disease

Categories: Eye diseases, Immune diseases

Aliases & Classifications for Mikulicz Disease

MalaCards integrated aliases for Mikulicz Disease:

Name: Mikulicz Disease 12 15 73
Mikulicz's Disease 12
Mikulicz Syndrome 76
Mikulicz' Disease 44

Classifications:



External Ids:

Disease Ontology 12 DOID:12900
ICD10 33 K11.8
MeSH 44 D008882
NCIt 50 C34819
SNOMED-CT 68 196478007 7826003
UMLS 73 C0026103

Summaries for Mikulicz Disease

MalaCards based summary : Mikulicz Disease, also known as mikulicz's disease, is related to igg4-related dacryoadenitis and sialadenitis and sjogren syndrome. An important gene associated with Mikulicz Disease is IL21 (Interleukin 21). The drugs Leflunomide and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, liver and eye, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Benign lymphoepithelial lesion is a type of benign enlargement of the parotid and/or lacrimal glands.... more...

Related Diseases for Mikulicz Disease

Diseases related to Mikulicz Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 igg4-related dacryoadenitis and sialadenitis 11.9
2 sjogren syndrome 9.9
3 pancreatitis 9.7
4 connective tissue disease 9.7
5 lymphosarcoma 9.7
6 lupus erythematosus 9.7
7 autoimmune pancreatitis 9.7
8 lung cancer 9.7
9 lymphoma 9.7
10 dacryoadenitis 9.7 AQP5 IL21
11 common variable immunodeficiency 9.7 AICDA IL21
12 lymphoma, non-hodgkin, familial 9.4 AICDA SMUG1

Graphical network of the top 20 diseases related to Mikulicz Disease:



Diseases related to Mikulicz Disease

Symptoms & Phenotypes for Mikulicz Disease

MGI Mouse Phenotypes related to Mikulicz Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 PHB PTGDR2 SMUG1 AQP5 IL21

Drugs & Therapeutics for Mikulicz Disease

Drugs for Mikulicz Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5 Antibodies Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antirheumatic Agents Phase 4
9 glucocorticoids Phase 4
10 Hormone Antagonists Phase 4
11 Hormones Phase 4
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
13 Immunoglobulin G Phase 4
14 Immunoglobulins Phase 4
15 Immunosuppressive Agents Phase 4
16 Liver Extracts Phase 4
17 Methylprednisolone acetate Phase 4
18 Methylprednisolone Hemisuccinate Phase 4
19 Prednisolone acetate Phase 4
20 Prednisolone hemisuccinate Phase 4
21 Prednisolone phosphate Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Leflunomide for Maintenance of Remission in IgG4 Related Disease Recruiting NCT02703194 Phase 4 Prednisone;Leflunomide
2 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695

Search NIH Clinical Center for Mikulicz Disease

Cochrane evidence based reviews: mikulicz' disease

Genetic Tests for Mikulicz Disease

Anatomical Context for Mikulicz Disease

MalaCards organs/tissues related to Mikulicz Disease:

41
Salivary Gland, Liver, Eye, Lung

Publications for Mikulicz Disease

Articles related to Mikulicz Disease:

(show all 21)
# Title Authors Year
1
Mikulicz Disease Mimicking Intraorbital Tumors. ( 28987847 )
2018
2
A rare case of Mikulicz disease. ( 27728670 )
2016
3
IgG4-related Mikulicz Disease in a 76-year-old Chinese Male: A Case Report. ( 24432837 )
2014
4
"Quasi-symmetric" FDG avidity of bilateral salivary glands in Mikulicz disease yielding false-positive staging in lung cancer. ( 22996254 )
2012
5
Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. ( 21898360 )
2012
6
Connective tissue diseases: Immune responses in Mikulicz disease differ from those in SS. ( 21971284 )
2011
7
Highly active state of autoimmune pancreatitis with mikulicz disease. ( 19904224 )
2010
8
Clinicopathologic similarities between Mikulicz disease and KA1ttner tumor. ( 20015799 )
2010
9
Sonographic diagnosis for Mikulicz disease. ( 19451003 )
2009
10
F-18 FDG PET-CT findings in Mikulicz disease and systemic involvement of IgG4-related lesions. ( 19352281 )
2009
11
Diffuse periairway thickening in patients with Mikulicz disease. ( 18728553 )
2008
12
Mikulicz disease of a minor salivary gland. ( 280669 )
1978
13
Mikulicz disease and subsequent lupus erythematosus development. ( 576964 )
1977
14
Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). ( 4943296 )
1971
15
The parotid gland in Mikulicz disease and Sjogren's syndrome. ( 13713214 )
1960
16
The parotid gland in Mikulicz disease and Sjogren's syndrome. ( 13713215 )
1960
17
Mikulicz' disease: report of a case of one week's duration. ( 14908801 )
1952
18
Benign lymphoepithelial lesion of the parotid gland adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, Mikulicz disease. ( 12998015 )
1952
19
Mikulicz' disease and Mikulicz' syndrome. ( 18119668 )
1949
20
A CASE OF MIKULICZ' DISEASE. ( 18168915 )
1930
21
LYMPHOID HYPERPLASIA OF LACRYMAL AND SALIVARY GLANDS: MIKULICZ' DISEASE. ( 17865927 )
1928

Variations for Mikulicz Disease

Expression for Mikulicz Disease

Search GEO for disease gene expression data for Mikulicz Disease.

Pathways for Mikulicz Disease

GO Terms for Mikulicz Disease

Biological processes related to Mikulicz Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 8.62 PHB PTGDR2

Sources for Mikulicz Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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