MCID: MKL001
MIFTS: 45

Mikulicz Disease

Categories: Bone diseases, Endocrine diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Mikulicz Disease

MalaCards integrated aliases for Mikulicz Disease:

Name: Mikulicz Disease 12 52 58 15 71
Igg4-Related Dacryoadenitis and Sialadenitis 12 52 58
Chronic Dacryoadenitis and Sialadenitis 52 58
Mikulicz's Disease 12 52
Mikulicz Syndrome 74 52
Mikulicz' Disease 43

Characteristics:

Orphanet epidemiological data:

58
igg4-related dacryoadenitis and sialadenitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare eye diseases
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:12900
MeSH 43 D008882
NCIt 49 C34819
SNOMED-CT 67 7826003
ICD10 32 K11.8
MESH via Orphanet 44 D008882
ICD10 via Orphanet 33 K11.8
UMLS via Orphanet 72 C0026103
Orphanet 58 ORPHA79078
UMLS 71 C0026103

Summaries for Mikulicz Disease

NIH Rare Diseases : 52 IgG4-related dacryoadenitis and sialoadenitis (formerly called Mikulicz disease) is an IgG4-related disease characterized by inflammation of the lacrimal glands (which produce tears), parotid glands, and submandibular glands (two of the major salivary glands ). In some cases, it also affects other glands or organs . The condition is usually painless, mainly causing mouth and eye dryness, and swelling over the affected glands. When other organs are affected, it can be accompanied by complications such as autoimmune pancreatitis , retroperitoneal fibrosis , and tubulointerstitial nephritis . The underlying cause of IgG4-related disease is still not known. Treatment involves corticosteroids , which are usually effective. Medicines that suppress the immune system (immunosuppressants) may also be used in cases that do not respond to corticosteroids. IgG4-related dacryoadenitis and sialoadenitis was previously considered a subtype of Sjogren syndrome , but it is now known to be a distinct condition.

MalaCards based summary : Mikulicz Disease, also known as igg4-related dacryoadenitis and sialadenitis, is related to cytokine deficiency and sialadenitis, and has symptoms including lumps of the face An important gene associated with Mikulicz Disease is IL21 (Interleukin 21), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and bone, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An autoimmune hypersensitivity disease that is characterized by chronic enlargement of the glands of the head and neck, has symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection.

Wikipedia : 74 Benign lymphoepithelial lesion is a type of benign enlargement of the parotid and/or lacrimal glands.... more...

Related Diseases for Mikulicz Disease

Diseases related to Mikulicz Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 450, show less)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 30.7 IL5 IL13
2 sialadenitis 30.4 ICOSLG CD4 CCR6
3 xerophthalmia 30.3 CRP CD4
4 salivary gland disease 30.1 ICOSLG CD4 CCR6
5 mononeuritis multiplex 30.1 CRP CD4
6 polyclonal hypergammaglobulinemia 30.0 CRP CD4
7 miliary tuberculosis 29.9 CRP CD4
8 keratoconjunctivitis sicca 29.9 IL4 CD4 CCR6
9 purpura 29.9 IL4 IL10 CRP
10 lymphoma, hodgkin, classic 29.8 IL13 ICOSLG CCR6
11 thrombocytopenia due to platelet alloimmunization 29.8 IL10 ICOSLG CD4 CCR6
12 dacryoadenitis 29.7 KNTC1 IL21 IL13 IL10 ICOSLG CD4
13 keratoconjunctivitis 29.6 IL5 IL4 IL13
14 parotitis 29.5 SPINK1 CRP CD4
15 acquired immunodeficiency syndrome 29.5 IL10 CRP CD4 CCR6
16 sarcoidosis 1 29.4 IL13 ICOSLG CRP CD4 CCR6
17 castleman disease 29.3 IL5 IL4 IL10 CRP
18 exanthem 29.2 IL10 ICOSLG CRP CD4 CCR6
19 hypereosinophilic syndrome 29.2 IL5 IL4 IL13 IL10
20 lymphadenitis 29.2 IL10 ICOSLG CRP CD4 CCR6
21 allergic rhinitis 29.1 IL5 IL4 IL13 IL10
22 multicentric castleman disease 29.1 IL5 IL21 IL10 CRP CD4
23 rhinitis 28.9 IL5 IL4 IL13 IL10 ICOSLG
24 bronchiolitis 28.6 IL5 IL4 IL13 IL10 CRP
25 crohn's disease 28.6 IL4 IL10 ICOSLG CRP CD4 CCR6
26 connective tissue disease 28.6 IL4 IL10 ICOSLG CRP CD4 CCR6
27 mycobacterium tuberculosis 1 28.6 IL4 IL10 ICOSLG CRP CD4 CCR6
28 igg4-related disease 28.2 SLAMF7 PLA2R1 KNTC1 IL4 ICOSLG CRP
29 myeloma, multiple 28.2 SLAMF7 IL4 IL10 ICOSLG CRP CD4
30 rheumatoid arthritis 28.1 IL4 IL13 IL10 CRP CD4 CCR6
31 autoimmune disease 27.7 IL5 IL4 IL21 IL13 IL10 ICOSLG
32 diffuse cutaneous systemic sclerosis 10.4 ICOSLG CCR6
33 pustulosis palmaris et plantaris 10.3 IL5 CCR6
34 selective immunoglobulin deficiency disease 10.3 SLAMF7 ICOSLG
35 suppurative lymphadenitis 10.3 CD4 CCR6
36 spongiotic dermatitis 10.3 CD4 CCR6
37 leukemia 10.3
38 thyroiditis 10.3
39 retroperitoneal fibrosis 10.3
40 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
41 inflammatory bowel disease 5 10.3 ICOSLG CCR6
42 autoimmune peripheral neuropathy 10.3 ICOSLG CD4
43 chancroid 10.3 CD4 CCR6
44 esophageal candidiasis 10.3 CD4 CCR6
45 pneumonic tularemia 10.3 CD4 CCR6
46 orbital plasma cell granuloma 10.3 KNTC1 CRP
47 lymphocytic hypophysitis 10.3
48 igg4-related thyroid disease 10.3
49 primary hypophysitis 10.3
50 blastomycosis 10.3 CD4 CCR6
51 chronic orbital inflammation 10.3 KNTC1 CRP
52 dermatographia 10.3 CRP CCR6
53 chronic graft versus host disease 10.3 IL10 CD4
54 monoclonal gammopathy of uncertain significance 10.3 SLAMF7 ICOSLG CCR6
55 autoimmune neuropathy 10.3 ICOSLG CD4
56 vernal conjunctivitis 10.3 IL4 CCR6
57 klebsiella pneumonia 10.2 CRP CCR6
58 tropical endomyocardial fibrosis 10.2 IL4 IL10
59 atopic keratoconjunctivitis 10.2 IL5 IL4
60 granulomatous angiitis 10.2 IL5 CRP
61 toxic megacolon 10.2 CRP CCR6
62 myelitis 10.2 IL10 ICOSLG CCR6
63 toxic oil syndrome 10.2 IL5 IL4
64 autoimmune hepatitis type 1 10.2 IL4 IL10
65 dysgammaglobulinemia 10.2 SLAMF7 ICOSLG
66 vulvovaginitis 10.2 IL10 CCR6
67 pneumonic plague 10.2 IL10 CD4
68 cough variant asthma 10.2 IL5 IL4
69 iga glomerulonephritis 10.2 PLA2R1 ICOSLG CCR6
70 sjogren syndrome 10.2
71 orofacial granulomatosis 10.2 IL4 IL10
72 aztreonam allergy 10.2 IL5 IL13
73 autoimmune disease of cardiovascular system 10.2 ICOSLG CD4 CCR6
74 ceftriaxone allergy 10.2 IL5 IL13
75 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL5 IL13
76 sporotrichosis 10.2 IL10 CD4
77 mite infestation 10.2 IL5 CD4
78 autoimmune glomerulonephritis 10.2 ICOSLG CD4 CCR6
79 respiratory syncytial virus infectious disease 10.2 IL5 IL13
80 childhood type dermatomyositis 10.2 ICOSLG CD4 CCR6
81 cefaclor allergy 10.2 IL5 IL13
82 immunoglobulin alpha deficiency 10.2 ICOSLG CD4 CCR6
83 cefuroxime allergy 10.2 IL5 IL13
84 orbital disease 10.2 KNTC1 CRP
85 eales disease 10.2 IL4 IL10
86 loeffler syndrome 10.2 IL5 IL13
87 progressive multifocal leukoencephalopathy 10.2 ICOSLG CD4 CCR6
88 thymus gland disease 10.2 ICOSLG CD4 CCR6
89 thymus cancer 10.2 ICOSLG CD4 CCR6
90 thrombocytopenic purpura, autoimmune 10.2 ICOSLG CD4 CCR6
91 pericardial tuberculosis 10.1 CRP CD4
92 toxocariasis 10.1 IL5 CRP
93 neuroretinitis 10.1 CRP CD4
94 breast abscess 10.1 CRP CD4
95 lymphatic system cancer 10.1 ICOSLG CD4 CCR6
96 pyomyositis 10.1 CRP CD4
97 optic papillitis 10.1 CRP CD4
98 vitiligo-associated multiple autoimmune disease susceptibility 1 10.1 ICOSLG CD4 CCR6
99 mature b-cell neoplasm 10.1 ICOSLG CD4 CCR6
100 enthesopathy 10.1 CRP CCR6
101 tertiary syphilis 10.1 CRP CD4
102 granulomatous hepatitis 10.1 CRP CD4
103 eosinophilic gastritis 10.1 IL5 IL13
104 acute orbital inflammation 10.1 CRP CD4
105 opportunistic bacterial infectious disease 10.1 CRP CD4
106 orange allergy 10.1 IL5 IL13
107 gastrointestinal tuberculosis 10.1 CRP CD4
108 intestinal tuberculosis 10.1 CRP CD4
109 cholangitis, primary sclerosing 10.1 ICOSLG CD4 CCR6
110 wissler's syndrome 10.1 CRP CD4
111 chorioretinitis 10.1 IL10 CD4
112 nocardiosis 10.1 CRP CD4
113 neurosarcoidosis 10.1 CRP CD4
114 bone marrow cancer 10.1 ICOSLG CD4 CCR6
115 x-linked monogenic disease 10.1 ICOSLG CD4 CCR6
116 mononeuritis of upper limb and mononeuritis multiplex 10.1 CRP CD4
117 cerebritis 10.1 CRP CD4
118 acute interstitial pneumonia 10.1 CRP CD4
119 blepharoconjunctivitis 10.1 IL4 CD4
120 hyper ige recurrent infection syndrome 1 10.1 IL10 CD4 CCR6
121 wells syndrome 10.1 IL5 CRP
122 cat-scratch disease 10.1 CRP CD4
123 hypopyon 10.1 CRP CD4
124 choroiditis 10.1 IL10 CD4
125 mastoiditis 10.1 CRP CD4
126 vaginitis 10.1 IL10 CD4 CCR6
127 abdominal tuberculosis 10.1 CRP CD4
128 bartonellosis 10.1 CRP CD4
129 viral encephalitis 10.1 IL10 CD4 CCR6
130 invasive aspergillosis 10.1 IL10 CD4 CCR6
131 lymphosarcoma 10.1
132 spondyloarthropathy 1 10.1 ICOSLG CRP CCR6
133 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IL5 IL13
134 keratitis, hereditary 10.1 IL10 CD4 CCR6
135 interstitial nephritis 10.1
136 thrombocytopenia 10.1
137 b-cell lymphoma 10.1
138 chromoblastomycosis 10.1 IL4 CCR6
139 lung abscess 10.1 CRP CD4
140 salmonellosis 10.1 IL10 CD4 CCR6
141 biliary tract disease 10.1 ICOSLG CRP CCR6
142 connective tissue cancer 10.1 ICOSLG CD4 CCR6
143 autoimmune disease of peripheral nervous system 10.1 ICOSLG CD4
144 corneal disease 10.1 IL10 CD4 CCR6
145 muscle tissue disease 10.1 ICOSLG CRP CCR6
146 viral esophagitis 10.1 CRP CD4
147 inflammatory bowel disease 18 10.1 IL4 IL10 CCR6
148 paragonimiasis 10.1 IL5 IL13
149 scabies 10.1 IL5 IL10 CD4
150 kwashiorkor 10.1 CRP CD4
151 funisitis 10.0 IL10 CRP CCR6
152 good syndrome 10.0 CRP CD4
153 perinatal necrotizing enterocolitis 10.0 IL10 CRP CCR6
154 duodenitis 10.0 CRP CD4
155 bacterial sepsis 10.0 IL10 CRP CCR6
156 elephantiasis 10.0 IL5 IL4 IL10
157 spondylitis 10.0 IL10 CRP CCR6
158 cervix disease 10.0 ICOSLG CD4 CCR6
159 cryptogenic organizing pneumonia 10.0 CRP CD4
160 reactive arthritis 10.0 IL10 CRP CCR6
161 fungal meningitis 10.0 IL10 CD4
162 cranial nerve palsy 10.0 CRP CD4
163 endomyocardial fibrosis 10.0 IL5 IL4 IL10
164 pleural empyema 10.0 CRP CD4
165 scleral disease 10.0 CRP CD4 CCR6
166 cow milk allergy 10.0 IL5 IL4 IL10
167 iritis 10.0 CRP CD4 CCR6
168 autoimmune vasculitis 10.0 IL4 CD4 CCR6
169 central nervous system vasculitis 10.0 CRP CD4 CCR6
170 relapsing-remitting multiple sclerosis 10.0 IL4 IL10 CCR6
171 pneumocystosis 10.0 CRP CD4 CCR6
172 blepharitis 10.0 IL4 CD4 CCR6
173 allergic bronchopulmonary aspergillosis 10.0 IL5 IL4 IL10
174 dermatitis herpetiformis 10.0 IL5 IL4 IL10
175 plasma protein metabolism disease 10.0 CRP CD4 CCR6
176 paracoccidioidomycosis 10.0 IL5 IL4 IL10
177 macs syndrome 10.0 IL10 CD4
178 aphthous stomatitis 10.0 IL5 IL4 IL10
179 trichuriasis 10.0 IL13 IL10 CCR6
180 syphilis 10.0 CRP CD4 CCR6
181 cutaneous t cell lymphoma 10.0 IL5 IL4 CCR6
182 filariasis 10.0 IL5 IL10 CRP
183 pleural disease 10.0 CRP CD4 CCR6
184 rubella 10.0 IL5 IL4 IL10
185 temporal arteritis 10.0 CRP CD4 CCR6
186 toxoplasmosis 10.0 IL5 IL4 IL10
187 iridocyclitis 10.0 CRP CD4
188 autosomal genetic disease 9.9 ICOSLG CD4 CCR6
189 reticulum cell sarcoma 9.9
190 human immunodeficiency virus type 1 9.9
191 autoimmune pancreatitis 9.9
192 lymphoma 9.9
193 nodal marginal zone lymphoma 9.9
194 mumps 9.9
195 pancytopenia 9.9
196 arthropathy 9.9
197 pancreatitis 9.9
198 vasculitis 9.9
199 lupus erythematosus 9.9
200 splenomegaly 9.9
201 warthin tumor 9.9
202 chronic meningitis 9.9 IL5 CRP CD4
203 corticosteroid allergy 9.9 IL5 IL4 CD4
204 gastric lymphoma 9.9
205 mastitis 9.9
206 uveitis 9.9
207 macroglobulinemia 9.9
208 amyloidosis 9.9
209 autoimmune disease of skin and connective tissue 9.9 IL5 ICOSLG CD4 CCR6
210 bullous skin disease 9.9 IL5 ICOSLG CD4 CCR6
211 lymphoma, mucosa-associated lymphoid type 9.9
212 pituitary hormone deficiency, combined, 2 9.9
213 lymphoma, non-hodgkin, familial 9.9
214 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
215 diffuse large b-cell lymphoma 9.9
216 mantle cell lymphoma 9.9
217 marginal zone b-cell lymphoma 9.9
218 mononeuropathy 9.9
219 sclerosing cholangitis 9.9
220 hypothyroidism 9.9
221 prostatitis 9.9
222 cystadenoma 9.9
223 epidermolysis bullosa 9.9
224 churg-strauss syndrome 9.9
225 hyperglobulinemic purpura 9.9
226 plasmacytoma 9.9
227 hyperglycemia 9.9
228 epidermolysis bullosa dystrophica 9.9
229 juvenile rheumatoid arthritis 9.9
230 diabetes insipidus 9.9
231 cholangitis 9.9
232 allergic angiitis 9.9
233 drug allergy 9.9 IL5 CRP CD4
234 metal allergy 9.9 IL4 IL10 CD4
235 chlamydia pneumonia 9.9 IL10 CRP CD4
236 mucocutaneous leishmaniasis 9.9 IL4 IL10 CD4
237 taeniasis 9.9 IL4 IL10 CD4
238 primary thrombocytopenia 9.9 IL10 ICOSLG CD4 CCR6
239 autoimmune disease of blood 9.9 IL10 ICOSLG CD4 CCR6
240 orchitis 9.9 IL10 CRP CD4
241 viral pneumonia 9.9 IL10 CRP CD4
242 listeriosis 9.9 IL10 ICOSLG CD4 CCR6
243 bronchopneumonia 9.9 IL10 CRP CD4
244 autoimmune disease of urogenital tract 9.9 IL10 ICOSLG CD4 CCR6
245 acute myocarditis 9.9 IL10 CRP CD4
246 spinal cord disease 9.9 IL10 ICOSLG CD4 CCR6
247 poliomyelitis 9.9 IL4 IL10 CD4
248 extrapulmonary tuberculosis 9.9 IL10 CRP CD4
249 x-linked recessive disease 9.9 IL10 ICOSLG CD4 CCR6
250 stomatitis 9.9 IL4 IL10 CD4
251 norwegian scabies 9.9 IL5 IL13 CD4
252 chlamydia 9.9 IL4 IL10 CRP
253 autoimmune lymphoproliferative syndrome 9.9 IL10 ICOSLG CD4
254 lipoid nephrosis 9.9 PLA2R1 IL13 IL10
255 neuromuscular disease 9.9 IL10 ICOSLG CD4 CCR6
256 strongyloidiasis 9.9 IL5 IL13 CD4
257 severe combined immunodeficiency, x-linked 9.9 IL4 IL21 IL13
258 chagas disease 9.8 IL4 IL10 CD4
259 pulmonary tuberculosis 9.8 IL4 IL10 CRP
260 combined thymoma 9.8 IL13 IL10 CD4
261 leptospirosis 9.8 IL4 IL10 CRP
262 mitral valve disease 9.8 IL4 IL10 CRP
263 brucellosis 9.8 IL4 IL10 CRP
264 tick infestation 9.8 IL4 CD4
265 lymphopenia 9.8 IL4 IL10 ICOSLG CCR6
266 overnutrition 9.8 IL10 ICOSLG CRP CCR6
267 chorioamnionitis 9.8 IL4 IL10 CRP
268 rheumatic disease 9.8 IL10 ICOSLG CRP CCR6
269 idiopathic interstitial pneumonia 9.8 IL4 IL13 CCR6
270 plasmodium falciparum malaria 9.8 IL4 IL10 CRP
271 toxic shock syndrome 9.8 IL4 IL10 CRP
272 egg allergy 9.8 IL5 IL4 IL10 CCR6
273 vernal keratoconjunctivitis 9.8 IL5 IL4 IL13
274 periodontitis 9.8 IL4 IL10 CRP
275 angiostrongyliasis 9.8 IL5 IL4 IL13
276 chronic rhinitis 9.8 IL5 IL4 IL13
277 kimura disease 9.8 IL5 IL4 IL13
278 peritonitis 9.8 IL4 IL10 CRP
279 latex allergy 9.8 IL5 IL4 IL13
280 vaginal discharge 9.8 CRP CD4
281 lichen disease 9.8 IL4 ICOSLG CD4 CCR6
282 viral hepatitis 9.8 IL4 IL10 CRP
283 eosinophilic pneumonia 9.8 IL5 IL4 IL13
284 aspergillosis 9.8 IL5 IL4 IL10 CCR6
285 pulmonary eosinophilia 9.8 IL5 IL4 IL13
286 onchocerciasis 9.8 IL5 IL4 IL13
287 beta-lactam allergy 9.8 IL4 IL13 IL10
288 cranial nerve disease 9.8 ICOSLG CRP CD4 CCR6
289 blood coagulation disease 9.8 ICOSLG CRP CD4 CCR6
290 penicillin allergy 9.8 IL4 IL13 IL10
291 bile duct disease 9.8 ICOSLG CRP CD4 CCR6
292 optic nerve disease 9.8 ICOSLG CRP CD4 CCR6
293 bullous pemphigoid 9.8 IL5 IL4 IL13
294 dengue hemorrhagic fever 9.8 IL4 IL13 IL10
295 bronchiolitis obliterans 9.8 IL13 IL10 CRP
296 diphtheria 9.7 IL5 IL4 IL13
297 folliculitis 9.7 IL5 IL4 CD4 CCR6
298 epididymis disease 9.7 CRP CD4
299 pulmonary edema 9.7 IL13 IL10 CRP
300 tuberculoid leprosy 9.7 IL4 IL10 CD4 CCR6
301 autoimmune gastritis 9.7 IL4 IL10 CD4 CCR6
302 genital herpes 9.7 IL4 IL10 CD4 CCR6
303 herpangina 9.7 IL4 IL10 CD4 CCR6
304 gingival disease 9.7 IL10 CRP CD4 CCR6
305 panuveitis 9.7 IL10 CRP CD4 CCR6
306 vaginal disease 9.7 IL10 CRP CD4 CCR6
307 middle ear disease 9.7 IL10 CRP CD4 CCR6
308 dysentery 9.7 IL10 CRP CD4 CCR6
309 anus disease 9.7 IL10 CRP CD4 CCR6
310 rectal disease 9.7 IL10 CRP CD4 CCR6
311 meningoencephalitis 9.7 IL10 CRP CD4 CCR6
312 acute cystitis 9.7 IL10 CRP CD4 CCR6
313 testicular disease 9.7 IL4 IL10 CD4 CCR6
314 herpes zoster 9.7 IL10 ICOSLG CRP CD4
315 scleritis 9.7 IL5 IL4 CRP CCR6
316 nickel allergic contact dermatitis 9.7 IL5 IL4 IL10 CD4
317 allergic contact dermatitis 9.7 IL5 IL4 IL10 CD4
318 contact dermatitis 9.7 IL5 IL4 IL10 CD4
319 african tick-bite fever 9.7 IL13 IL10
320 meningitis 9.6 IL5 IL4 IL10 CRP
321 posterior uveitis 9.6 IL5 IL4 IL13 CCR6
322 urinary schistosomiasis 9.6 IL5 IL4 IL13 ICOSLG
323 gastroenteritis 9.6 IL5 IL4 IL10 CRP
324 otitis media 9.6 IL5 IL4 IL10 CRP
325 common variable immunodeficiency 9.6 IL5 IL4 IL21 IL10 ICOSLG
326 hashimoto thyroiditis 9.6 IL5 IL4 IL10 CRP
327 parotid disease 9.6 SPINK1 CRP CD4
328 alopecia areata 9.6 IL4 IL13 IL10 ICOSLG
329 conjunctivitis 9.6 IL5 IL4 IL13 IL10
330 schistosomiasis 9.6 IL5 IL4 IL13 IL10
331 acute pancreatitis 9.6 SPINK1 IL10 CRP
332 esophagitis 9.5 IL5 IL4 IL13 IL10
333 loiasis 9.5 IL5 IL4 IL13 IL10
334 eosinophilic meningitis 9.5 IL5 IL4 IL13 IL10
335 ige responsiveness, atopic 9.5 IL5 IL4 IL13 IL10
336 milk allergy 9.5 IL5 IL4 IL13 IL10
337 allergic conjunctivitis 9.5 IL5 IL4 IL13 IL10
338 streptococcus pneumonia 9.5 IL4 IL10 CRP CD4
339 granulomatosis with polyangiitis 9.5 IL5 ICOSLG CRP CD4 CCR6
340 cutaneous leishmaniasis 9.5 IL5 IL4 IL13 IL10
341 food allergy 9.5 IL5 IL4 IL13 IL10
342 chronic fatigue syndrome 9.5 IL5 IL4 IL13 IL10
343 bacterial infectious disease 9.5 IL10 ICOSLG CRP CD4 CCR6
344 autoimmune disease of eyes, ear, nose and throat 9.5 IL4 IL10 ICOSLG CD4 CCR6
345 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.5 IL4 IL10 ICOSLG CD4 CCR6
346 lacrimal apparatus disease 9.5 IL4 IL10 ICOSLG CD4 CCR6
347 autoimmune disease of endocrine system 9.5 IL4 IL10 ICOSLG CD4 CCR6
348 b cell deficiency 9.5 IL4 IL10 ICOSLG CD4 CCR6
349 combined t cell and b cell immunodeficiency 9.5 IL4 IL10 ICOSLG CD4 CCR6
350 neuromuscular junction disease 9.5 IL4 IL10 ICOSLG CD4 CCR6
351 autoimmune disease of gastrointestinal tract 9.5 IL4 IL10 ICOSLG CD4 CCR6
352 hypotrichosis 1 9.5 IL4 IL10 ICOSLG CD4 CCR6
353 kawasaki disease 9.5 IL4 IL10 CRP CD4
354 allergic asthma 9.5 IL5 IL4 IL13 IL10
355 hair disease 9.5 IL4 IL10 ICOSLG CD4 CCR6
356 bacterial pneumonia 9.5 IL10 ICOSLG CRP CD4 CCR6
357 chediak-higashi syndrome 9.5 IL4 IL10 ICOSLG CD4 CCR6
358 blood platelet disease 9.5 IL10 ICOSLG CRP CD4 CCR6
359 human immunodeficiency virus infectious disease 9.5 IL4 IL10 ICOSLG CD4 CCR6
360 demyelinating disease 9.5 IL4 IL10 ICOSLG CD4 CCR6
361 glucose metabolism disease 9.5 IL10 ICOSLG CRP CD4 CCR6
362 acquired metabolic disease 9.5 IL10 ICOSLG CRP CD4 CCR6
363 acute proliferative glomerulonephritis 9.5 PLA2R1 ICOSLG CRP CD4 CCR6
364 yellow fever 9.5 IL5 IL4 ICOSLG CRP CCR6
365 leprosy 3 9.5 IL5 IL4 IL10 CD4 CCR6
366 sezary's disease 9.5 IL5 IL4 IL10 CD4 CCR6
367 chronic mucocutaneous candidiasis 9.5 IL5 IL4 IL10 CD4 CCR6
368 leukemia, chronic lymphocytic 9.5 IL4 IL10 ICOSLG CD4 CCR6
369 omenn syndrome 9.5 IL5 IL4 IL10 ICOSLG CD4
370 leukemia, acute myeloid 9.4 IL4 IL10 ICOSLG CD4 CCR6
371 cardiomyopathy, familial hypertrophic, 20 9.4 IL13 CD4
372 esophagitis, eosinophilic, 1 9.4 IL5 IL4 IL13 ICOSLG CCR6
373 urticaria 9.4 IL5 IL4 IL13 CRP
374 mycoplasma pneumoniae pneumonia 9.4 IL4 IL13 IL10 CRP
375 renal cell carcinoma, nonpapillary 9.4 IL4 IL21 IL13 ICOSLG CCR6
376 visceral leishmaniasis 9.4 IL4 IL13 IL10 CRP
377 systemic scleroderma 9.4 IL4 ICOSLG CRP CD4 CCR6
378 mouth disease 9.4 IL13 IL10 ICOSLG CRP CCR6
379 colitis 9.4 IL4 IL13 IL10 ICOSLG CCR6
380 dermatitis 9.3 IL5 IL4 IL13 IL10 CCR6
381 primary systemic mycosis 9.3 IL4 IL10 CRP CD4 CCR6
382 intrinsic asthma 9.3 IL5 IL4 IL13 ICOSLG CD4
383 cryptococcosis 9.3 IL4 IL13 IL10 CD4 CCR6
384 cellulitis 9.3 IL5 IL10 ICOSLG CRP CD4 CCR6
385 trichinosis 9.2 IL5 IL4 IL13 IL10 CD4
386 filarial elephantiasis 9.2 IL5 IL4 IL13 IL10 CD4
387 psoriatic arthritis 9.2 IL4 IL13 IL10 CRP CCR6
388 arthritis 9.2 IL4 IL13 IL10 CRP CCR6
389 ulcerative colitis 9.2 IL4 IL13 IL10 CRP CCR6
390 respiratory failure 9.2 IL5 IL13 IL10 CRP CD4
391 pneumonia 9.1 IL5 IL4 IL13 IL10 CRP
392 proteasome-associated autoinflammatory syndrome 1 9.1 IL5 IL4 IL13 IL10 CRP
393 bronchitis 9.1 IL5 IL4 IL13 IL10 CRP
394 tetanus 9.1 IL5 IL4 IL13 IL10 CRP
395 interstitial lung disease 9.1 IL5 IL4 IL13 IL10 CRP
396 lung disease 9.1 IL5 IL4 IL13 IL10 CRP
397 peanut allergy 9.1 IL5 IL4 IL13 IL10 ICOSLG CCR6
398 leishmaniasis 9.1 IL5 IL4 IL13 IL10 CRP
399 chickenpox 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
400 coccidiosis 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
401 lymph node disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
402 extrinsic cardiomyopathy 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
403 hypersensitivity reaction type iv disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
404 commensal bacterial infectious disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
405 uveal disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
406 lymphatic system disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
407 autoimmune disease of musculoskeletal system 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
408 bone inflammation disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
409 peripheral nervous system disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
410 muscular disease 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
411 body mass index quantitative trait locus 11 9.1 IL4 IL10 ICOSLG CRP CD4 CCR6
412 diabetes mellitus, noninsulin-dependent 9.0 IL4 IL10 ICOSLG CRP CD4 CCR6
413 autoimmune disease of central nervous system 9.0 IL4 IL13 IL10 ICOSLG CD4 CCR6
414 viral infectious disease 9.0 IL4 IL13 IL10 ICOSLG CD4 CCR6
415 immune deficiency disease 9.0 IL4 IL13 IL10 ICOSLG CD4 CCR6
416 intestinal schistosomiasis 9.0 IL5 IL4 IL13 IL10 CD4 CCR6
417 multiple sclerosis 9.0 IL5 IL4 IL13 IL10 CD4 CCR6
418 splenic disease 8.9 IL4 IL13 IL10 CRP CD4 CCR6
419 psoriasis 8.8 IL5 IL4 IL21 IL13 IL10 CD4
420 nut allergy 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
421 chronic conjunctivitis 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
422 nasal cavity disease 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
423 common cold 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
424 respiratory allergy 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
425 parasitic helminthiasis infectious disease 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
426 leukocyte disease 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
427 asthma 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
428 allergic hypersensitivity disease 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
429 dermatitis, atopic 8.8 IL5 IL4 IL13 IL10 ICOSLG CD4
430 collagen disease 8.7 IL4 IL13 IL10 ICOSLG CRP CD4
431 behcet syndrome 8.6 IL4 IL13 IL10 ICOSLG CRP CD4
432 diabetes mellitus, insulin-dependent 8.6 IL4 IL13 IL10 ICOSLG CRP CD4
433 severe combined immunodeficiency 8.6 IL5 IL4 IL21 IL13 IL10 ICOSLG
434 malaria 8.6 IL5 IL4 IL13 IL10 ICOSLG CRP
435 inflammatory bowel disease 8.5 IL5 IL4 IL21 IL13 IL10 ICOSLG
436 conjunctival disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
437 nose disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
438 parasitic protozoa infectious disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
439 opportunistic mycosis 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
440 paranasal sinus disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
441 bronchial disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
442 primary bacterial infectious disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
443 upper respiratory tract disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
444 immune system disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
445 pulmonary disease, chronic obstructive 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
446 pulmonary fibrosis, idiopathic 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
447 skin disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
448 eye disease 8.4 IL5 IL4 IL13 IL10 ICOSLG CRP
449 celiac disease 1 8.2 IL5 IL4 IL21 IL13 IL10 ICOSLG
450 systemic lupus erythematosus 7.9 SLAMF7 IL5 IL4 IL21 IL13 IL10

Graphical network of the top 20 diseases related to Mikulicz Disease:



Diseases related to Mikulicz Disease

Symptoms & Phenotypes for Mikulicz Disease

Symptoms:

12 (showing 1, show less)
  • lumps of the face

MGI Mouse Phenotypes related to Mikulicz Disease:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CCR6 CD4 IL10 IL13 IL21 IL4
2 digestive/alimentary MP:0005381 9.73 CD4 IL10 IL13 IL4 IL5 SPINK1
3 homeostasis/metabolism MP:0005376 9.65 CCR6 CD4 CRP IL10 IL13 IL21
4 immune system MP:0005387 9.36 CCR6 CD4 CRP IL10 IL13 IL21

Drugs & Therapeutics for Mikulicz Disease

Drugs for Mikulicz Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 20, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
7
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Anti-Inflammatory Agents Phase 4
10 Immunologic Factors Phase 4
11 Liver Extracts Phase 4
12 glucocorticoids Phase 4
13 Immunoglobulin G Phase 4
14 Methylprednisolone Acetate Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Hormone Antagonists Phase 4
17 Immunoglobulins Phase 4
18 Immunosuppressive Agents Phase 4
19 Antibodies Phase 4
20 Hormones Phase 4

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
2 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448

Search NIH Clinical Center for Mikulicz Disease

Cochrane evidence based reviews: mikulicz' disease

Genetic Tests for Mikulicz Disease

Anatomical Context for Mikulicz Disease

MalaCards organs/tissues related to Mikulicz Disease:

40
Eye, Salivary Gland, Bone, Liver, Bone Marrow, Lung, Skin

Publications for Mikulicz Disease

Articles related to Mikulicz Disease:

(showing 88, show less)
# Title Authors PMID Year
1
Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. 52 61
28916523 2017
2
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. 61
30354922 2019
3
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. 61
29656682 2019
4
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. 61
30696319 2019
5
Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients. 61
30701685 2019
6
IgG4-related respiratory disease. 61
30474465 2019
7
Stage classification of IgG4-related dacryoadenitis and sialadenitis by the serum cytokine environment. 61
29385874 2018
8
Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. 61
30173184 2018
9
Estimation of proton density fat fraction of the salivary gland. 61
29376736 2018
10
Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions. 61
29207199 2018
11
Mikulicz Disease Mimicking Intraorbital Tumors. 61
28987847 2018
12
[Non-Hodgkin's lymphoma mimicking Mikulicz disease: a case report]. 61
27987516 2016
13
Gallium SPECT/CT in evaluation of IgG4-related disease: A case report and literature review. 61
27631251 2016
14
IgG4-related disease. 61
26259069 2016
15
IgG4-related hypophysitis presenting as diabetes insipidus with tubulo-interstital nephritis and mediastinal lymphadenopathy. 61
27398219 2016
16
[Review of ear and nose and throat involvement in IgG4-RD]. 61
26911076 2015
17
[112th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Recent Progress in IgG4-related Disease: IgG4-related Dacryoadenitis and Sialadenitis]. 61
30160920 2015
18
[IgG4-related Dacryoadenitis and Sialadenitis]. 61
30160881 2015
19
Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) and for differentiating it from Sjögren's syndrome (SS), with an emphasis on sonography. 61
26298875 2015
20
IgG4-related Mikulicz Disease in a 76-year-old Chinese Male: A Case Report. 61
24432837 2015
21
IgG4 related disease of the head and neck. 61
25804380 2015
22
Diagnostic criteria for IgG4-related ophthalmic disease. 61
25392273 2015
23
Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment. 61
24907151 2015
24
IgG4-related skin disease. 61
25065694 2014
25
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. 61
24593171 2014
26
¹⁸F-FDG PET-CT usefulness in extra-pancreatic involvement in IgG4 related diseases. 61
24630373 2014
27
Mechanisms and assessment of IgG4-related disease: lessons for the rheumatologist. 61
24296677 2014
28
IgG4-related multiorgan disease: report of the first autopsy case. 61
23645656 2013
29
Rare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry. 61
23146570 2013
30
IgG4-related disease in the head and neck. 61
23068303 2012
31
"Quasi-symmetric" FDG avidity of bilateral salivary glands in Mikulicz disease yielding false-positive staging in lung cancer. 61
22996254 2012
32
IgG4-related disease of the head and neck: CT and MR imaging manifestations. 61
23150850 2012
33
Autoimmune pancreatitis that developed over a 3-month observation period for IgG4-related dacryoadenitis and sialadenitis. 61
26182321 2012
34
Utility of FDG PET/CT in IgG4-related systemic disease. 61
22119099 2012
35
Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. 61
21898360 2012
36
[Usefulness of measuring serum IgG4 level as diagnostic and treatment marker in IgG4-related disease]. 61
22374440 2012
37
Jan Mikulicz-Radecki (1850-1905): his impact on modern medicine. 61
25872240 2012
38
[A case of IgG4-related disease with marked thickening of the bronchial wall]. 61
22352056 2011
39
Cytohistological features of rhinoscleroma. 61
22234117 2011
40
Connective tissue diseases: Immune responses in Mikulicz disease differ from those in SS. 61
21971284 2011
41
Membranous nephropathy associated with IgG4-related disease. 61
21658826 2011
42
IgG4-associated sialadenitis. 61
21124091 2011
43
Clinicopathologic similarities between Mikulicz disease and Küttner tumor. 61
20015799 2010
44
[Clinical analysis of 11 cases of Mikulicz disease in the salivary glands]. 61
21176583 2010
45
[The first experience of using rituximab in Mikulicz disease]. 61
20731115 2010
46
Highly active state of autoimmune pancreatitis with mikulicz disease. 61
19904224 2010
47
[Autoimmune pancreatitis]. 61
19860211 2009
48
Sonographic diagnosis for Mikulicz disease. 61
19451003 2009
49
F-18 FDG PET-CT findings in Mikulicz disease and systemic involvement of IgG4-related lesions. 61
19352281 2009
50
Diffuse periairway thickening in patients with Mikulicz disease. 61
18728553 2008
51
[Multicentric Castleman disease-like case characterized by lymphadenopathy and polyclonal hypergammaglobulinemia associated with so-called Mikulicz disease]. 61
17441481 2007
52
Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature. 61
14716060 2003
53
[Kimura disease]. 61
10230233 1999
54
[Mikulicz disease as the beginning of AIDS]. 61
8037370 1994
55
Mikulicz syndrome and disease: 2 case reports highlighting the difference. 61
8475708 1993
56
[Diagnosis of periorbital diseases by means of ultrasound]. 61
1916424 1991
57
[Rare from of Mikulicz' disease]. 61
4013308 1985
58
[Sialography (the fourth report)--Sjögren syndrome and Mikulicz disease]. 61
6737767 1984
59
Mikulicz disease of a minor salivary gland. 61
280669 1978
60
[Mikulicz' disease, rheumatoid arthritis and cutaneous-muscular microangiopathy]. 61
609816 1977
61
Mikulicz disease and subsequent lupus erythematosus development. 61
576964 1977
62
Benign lymphoepithelial lesions of the salivary glands. 61
1173025 1975
63
[Mikulicz' disease]. 61
4523031 1973
64
[Some specific features of the clinical picture, diagnosis and treatment in cases of the salivary and lacrimal gland disease with Mikulicz' disease]. 61
4516270 1973
65
[Epithelial tumors of the salivary glands containing lymphatic tissue. II. Mikulicz' disease]. 61
4702235 1973
66
Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). 61
4943296 1971
67
[A rare clinical picture of Mikulicz' disease]. 61
5280626 1971
68
[Results of radiotherapy in Mikulicz' disease]. 61
5441642 1970
69
[Mikulicz' disease]. 61
5277398 1969
70
[A case of Mikulicz disease in a 7-year-old girl]. 61
5252352 1969
71
[Mikulicz disease in the course of senile arthropathy]. 61
5246719 1968
72
[Symptomatology of Mikulicz' disease]. 61
5728957 1968
73
[On the problem of Mikulicz' disease]. 61
5688450 1968
74
[STUDIES ON MIKULICZ' DISEASE AND S'J'OGREN'S SYNDROME]. 61
14159673 1964
75
[CONSIDERATIONS ON A CASE OF MIKULICZ' DISEASE]. 61
14118457 1963
76
[Salivary gland diseases. I. The use of Co60 in Mikulicz' disease. II. Submaxillary gland disease and its therapy]. 61
13718373 1961
77
The parotid gland in Mikulicz disease and Sjogren's syndrome. 61
13713214 1960
78
The parotid gland in Mikulicz disease and Sjogren's syndrome. 61
13713215 1960
79
[Case of Mikulicz' disease]. 61
13621542 1958
80
[Comparative studies on the salivary and lacrimal glands in connection with the pathogenesis of Sjögren syndrome and Mikulicz disease]. 61
13530661 1957
81
Benign lymphoepithelial lesion of the parotid gland adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, Mikulicz disease. 61
12998015 1952
82
[Mikulicz disease and its atypical localizations]. 61
13041848 1952
83
[Mikulicz disease]. 61
12998075 1952
84
[Differentialdiagnose and pathogenesis of Mikulicz disease; casuistic under consideration of changes in bone marrow and serum protein]. 61
12976227 1952
85
Mikulicz' disease: report of a case of one week's duration. 61
14908801 1952
86
Mikulicz' disease and Mikulicz' syndrome. 61
18119668 1949
87
A CASE OF MIKULICZ' DISEASE. 61
18168915 1930
88
LYMPHOID HYPERPLASIA OF LACRYMAL AND SALIVARY GLANDS: MIKULICZ' DISEASE. 61
17865927 1928

Variations for Mikulicz Disease

Expression for Mikulicz Disease

Search GEO for disease gene expression data for Mikulicz Disease.

Pathways for Mikulicz Disease

Pathways related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 26, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 SLAMF7 IL5 IL4 IL13 IL10 ICOSLG
2
Show member pathways
13.51 IL5 IL4 IL21 IL13 IL10 CD4
3
Show member pathways
13.19 IL5 IL4 IL21 IL13 IL10 CD4
4
Show member pathways
13.07 IL5 IL4 IL21 IL13 IL10 CD4
5
Show member pathways
12.61 IL5 IL4 IL21 IL13 IL10 ICOSLG
6
Show member pathways
12.49 IL4 IL10 ICOSLG CD4
7
Show member pathways
12.45 IL5 IL4 IL10 CD4
8
Show member pathways
12.38 IL5 IL4 IL21 IL13 IL10 CD4
9
Show member pathways
12.17 IL5 IL4 IL21 IL13 IL10
10
Show member pathways
12.11 IL5 IL4 IL13 IL10
11
Show member pathways
11.91 IL21 IL10 CD4
12 11.84 IL4 IL13 IL10
13 11.8 IL5 IL4 IL10 CD4
14 11.76 IL5 IL4 CD4
15 11.67 IL5 IL4 IL13
16 11.59 IL4 IL13 IL10
17 11.52 IL5 IL4 IL13
18 11.51 IL5 IL4 IL10
19 11.42 IL21 IL10 CD4
20 11.38 IL4 IL13 IL10
21 11.22 IL5 IL4 IL13 IL10 CD4
22 11.16 IL5 IL4 IL13
23 11 IL5 IL4 IL13 IL10 CD4 CCR6
24 10.97 IL5 IL4 IL13 IL10
25 10.86 IL5 IL4 IL21 IL13 IL10
26 10.82 IL5 IL4 IL13 IL10 CD4

GO Terms for Mikulicz Disease

Cellular components related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 SPINK1 IL5 IL4 IL21 IL13 IL10
2 external side of plasma membrane GO:0009897 9.46 IL13 ICOSLG CD4 CCR6
3 extracellular region GO:0005576 9.23 SPINK1 PLA2R1 IL5 IL4 IL21 IL13

Biological processes related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 15, show less)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.07 IL5 IL4 IL21 IL10 ICOSLG CD4
2 inflammatory response GO:0006954 9.85 IL5 IL13 IL10 CRP
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IL4 IL21 IL13
4 positive regulation of T cell proliferation GO:0042102 9.63 IL4 IL21 CD4
5 T cell activation GO:0042110 9.58 IL4 ICOSLG CD4
6 cytokine-mediated signaling pathway GO:0019221 9.55 IL5 IL4 IL13 IL10 CD4
7 positive regulation of macrophage activation GO:0043032 9.54 IL13 IL10
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL4 IL10
9 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.49 IL4 IL10
10 type 2 immune response GO:0042092 9.43 IL4 IL10
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL4 IL13 IL10
12 regulation of isotype switching GO:0045191 9.37 IL4 IL10
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL4 IL13
14 positive regulation of B cell proliferation GO:0030890 9.26 IL5 IL4 IL21 IL13
15 immune response GO:0006955 9.17 IL5 IL4 IL21 IL13 IL10 CD4

Molecular functions related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL4 IL21 IL13
2 cytokine activity GO:0005125 9.02 IL5 IL4 IL21 IL13 IL10

Sources for Mikulicz Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....