MCID: MKL001
MIFTS: 46

Mikulicz Disease

Categories: Bone diseases, Endocrine diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Mikulicz Disease

MalaCards integrated aliases for Mikulicz Disease:

Name: Mikulicz Disease 12 52 58 15 71
Igg4-Related Dacryoadenitis and Sialadenitis 12 52 58
Chronic Dacryoadenitis and Sialadenitis 52 58
Mikulicz's Disease 12 52
Mikulicz Syndrome 74 52
Mikulicz' Disease 43

Characteristics:

Orphanet epidemiological data:

58
igg4-related dacryoadenitis and sialadenitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare eye diseases
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:12900
MeSH 43 D008882
NCIt 49 C34819
SNOMED-CT 67 7826003
ICD10 32 K11.8
MESH via Orphanet 44 D008882
ICD10 via Orphanet 33 K11.8
UMLS via Orphanet 72 C0026103
Orphanet 58 ORPHA79078
UMLS 71 C0026103

Summaries for Mikulicz Disease

NIH Rare Diseases : 52 IgG4-related dacryoadenitis and sialoadenitis (formerly called Mikulicz disease) is an IgG4-related disease characterized by inflammation of the lacrimal glands (which produce tears), parotid glands, and submandibular glands (two of the major salivary glands ). In some cases, it also affects other glands or organs . The condition is usually painless, mainly causing mouth and eye dryness, and swelling over the affected glands. When other organs are affected, it can be accompanied by complications such as autoimmune pancreatitis , retroperitoneal fibrosis , and tubulointerstitial nephritis . The underlying cause of IgG4-related disease is still not known. Treatment involves corticosteroids , which are usually effective. Medicines that suppress the immune system (immunosuppressants) may also be used in cases that do not respond to corticosteroids. IgG4-related dacryoadenitis and sialoadenitis was previously considered a subtype of Sjogren syndrome , but it is now known to be a distinct condition.

MalaCards based summary : Mikulicz Disease, also known as igg4-related dacryoadenitis and sialadenitis, is related to cytokine deficiency and keratoconjunctivitis, and has symptoms including lumps of the face An important gene associated with Mikulicz Disease is IL21 (Interleukin 21), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Leflunomide have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and bone, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An autoimmune hypersensitivity disease that is characterized by chronic enlargement of the glands of the head and neck, has symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection.

Wikipedia : 74 Benign lymphoepithelial lesion is a type of benign enlargement of the parotid and/or lacrimal glands.... more...

Related Diseases for Mikulicz Disease

Diseases related to Mikulicz Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 563, show less)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 31.0 IL5 IL13
2 keratoconjunctivitis 30.2 IL5 IL4 IL13
3 keratoconjunctivitis sicca 30.1 IL4 CD4 CCR6
4 dacryoadenitis 30.0 KNTC1 IL4 IL21 IL13 IL10 CD4
5 uveitis 29.9 IL4 IL10 CXCR5
6 churg-strauss syndrome 29.9 IL5 IL10 CD40LG
7 xerophthalmia 29.9 CRP CD40LG CD4
8 interstitial nephritis 29.9 CRP CD40LG CCR6
9 juvenile arthritis 29.9 IL10 CRP
10 autoimmune pancreatitis 29.8 IL10 CD40LG CD4
11 rhinitis 29.8 IL5 IL4 IL13 IL10
12 hypereosinophilic syndrome 29.8 IL5 IL4 IL13 IL10
13 allergic rhinitis 29.7 IL5 IL4 IL13 IL10
14 vasculitis 29.6 IL10 CRP CD40LG
15 cholangitis 29.6 IL10 CRP CD40LG
16 polyclonal hypergammaglobulinemia 29.6 CRP CD40LG CD4
17 mononeuritis multiplex 29.5 CRP CD40LG CD4
18 thrombocytopenia due to platelet alloimmunization 29.5 IL10 CD40LG CD4 CCR6
19 salivary gland disease 29.5 IL10 CD40LG CD4 CCR6
20 miliary tuberculosis 29.5 CRP CD40LG CD4
21 castleman disease 29.5 IL5 IL4 IL10 CRP
22 purpura 29.4 IL4 IL10 CRP CD40LG
23 sarcoidosis 1 29.4 IL13 CRP CD40LG CD4 CCR6
24 lymphadenitis 29.4 IL10 CRP CD4 CCR6
25 lymphoma, mucosa-associated lymphoid type 29.3 CXCR5 CD40LG CD4 CCR6
26 multicentric castleman disease 29.1 IL5 IL21 IL10 CRP CD4
27 pancytopenia 29.1 CRP CD40LG CD4
28 crohn's disease 29.0 IL4 IL10 CRP CD4 CCR6
29 lymphoma 29.0 IL4 IL10 CXCR5 CD40LG CCR6
30 igg4-related disease 29.0 SLAMF7 KNTC1 IL4 CRP CD4 CCR6
31 mycobacterium tuberculosis 1 29.0 IL4 IL10 CRP CD4 CCR6
32 parotitis 28.9 SPINK1 CRP CD40LG CD4
33 exanthem 28.9 IL10 CRP CD40LG CD4 CCR6
34 lymphoma, non-hodgkin, familial 28.5 IL4 IL10 CXCR5 CD40LG CD4 CCR6
35 bronchiolitis 28.5 IL5 IL4 IL13 IL10 CRP CD40LG
36 connective tissue disease 28.5 IL4 IL10 CRP CD40LG CD4 CCR6
37 acquired immunodeficiency syndrome 28.3 IL10 CXCR5 CRP CD40LG CD4 CCR6
38 autoimmune disease 28.0 IL5 IL4 IL21 IL13 IL10 CRP
39 myeloma, multiple 27.9 SLAMF7 IL4 IL10 CRP CD40LG CD4
40 rheumatoid arthritis 27.5 IL4 IL13 IL10 CXCR5 CRP CD40LG
41 aztreonam allergy 10.4 IL5 IL13
42 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL13
43 respiratory syncytial virus infectious disease 10.4 IL5 IL13
44 cefaclor allergy 10.4 IL5 IL13
45 cefuroxime allergy 10.4 IL5 IL13
46 ceftriaxone allergy 10.4 IL5 IL13
47 loeffler syndrome 10.4 IL5 IL13
48 atopic keratoconjunctivitis 10.4 IL5 IL4
49 eosinophilic gastritis 10.4 IL5 IL13
50 tropical endomyocardial fibrosis 10.4 IL4 IL10
51 breast implant-associated anaplastic large cell lymphoma 10.4 IL13 CCR6
52 toxic oil syndrome 10.4 IL5 IL4
53 vernal conjunctivitis 10.4 IL4 CCR6
54 leukemia 10.3
55 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
56 autoimmune hepatitis type 1 10.3 IL4 IL10
57 thyroiditis 10.3
58 retroperitoneal fibrosis 10.3
59 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 IL5 IL13
60 orofacial granulomatosis 10.3 IL4 IL10
61 nut allergy 10.3 IL5 IL13 CCR6
62 esophageal candidiasis 10.3 CD4 CCR6
63 chronic graft versus host disease 10.3 IL10 CD4
64 eales disease 10.3 IL4 IL10
65 lymphocytic hypophysitis 10.3
66 igg4-related thyroid disease 10.3
67 primary hypophysitis 10.3
68 pneumonic tularemia 10.3 CD4 CCR6
69 blepharoconjunctivitis 10.3 IL4 CD4
70 paragonimiasis 10.3 IL5 IL13
71 neurosyphilis 10.3 IL10 CXCR5
72 subcutaneous mycosis 10.3 CD4 CCR6
73 eosinophilic gastroenteritis 10.2 IL5 IL4 CCR6
74 cough variant asthma 10.2 IL5 IL4 IL13
75 vernal keratoconjunctivitis 10.2 IL5 IL4 IL13
76 intrinsic asthma 10.2 IL5 IL4 IL13
77 severe combined immunodeficiency, x-linked 10.2 IL4 IL21 IL13
78 angiostrongyliasis 10.2 IL5 IL4 IL13
79 cork-handlers' disease 10.2 CD40LG CD4
80 chronic rhinitis 10.2 IL5 IL4 IL13
81 kimura disease 10.2 IL5 IL4 IL13
82 orbital plasma cell granuloma 10.2 KNTC1 CRP
83 latex allergy 10.2 IL5 IL4 IL13
84 american histoplasmosis 10.2 CD40LG CD4
85 syphilitic meningitis 10.2 CD40LG CD4
86 erythema multiforme 10.2 IL5 IL4 IL13
87 sjogren syndrome 10.2
88 eosinophilic pneumonia 10.2 IL5 IL4 IL13
89 early yaws 10.2 CD40LG CD4
90 onchocerciasis 10.2 IL5 IL4 IL13
91 granulomatous angiitis 10.2 IL5 CRP
92 asymptomatic neurosyphilis 10.2 CD40LG CD4
93 orbital cellulitis 10.2 KNTC1 CRP
94 ascaris lumbricoides infection 10.2 IL5 IL13 IL10
95 latent syphilis 10.2 CD40LG CD4
96 gastroduodenitis 10.2 CD40LG CD4
97 primary syphilis 10.2 CD40LG CD4
98 endomyocardial fibrosis 10.2 IL5 IL4 IL10
99 status asthmaticus 10.2 IL5 IL13 IL10
100 transient arthritis 10.2 CD40LG CD4
101 necrotizing ulcerative gingivitis 10.2 CD40LG CD4
102 intestinal tuberculosis 10.2 CRP CD4
103 radiculopathy 10.2 IL5 IL13 IL10
104 tertiary neurosyphilis 10.2 CD40LG CD4
105 bacillary angiomatosis 10.2 CD40LG CD4
106 cow milk allergy 10.2 IL5 IL4 IL10
107 acute retinal necrosis syndrome 10.2 CD40LG CD4
108 scabies 10.2 IL10 CD4 CCR6
109 strongyloidiasis 10.1 IL5 IL13 CD4
110 blepharitis 10.1 IL4 CD4 CCR6
111 transient hypogammaglobulinemia 10.1 IL10 CD40LG
112 beta-lactam allergy 10.1 IL4 IL13 IL10
113 pneumonic plague 10.1 IL10 CD4
114 primary progressive multiple sclerosis 10.1 IL4 IL10 CCR6
115 cerebral lymphoma 10.1 CD40LG CD4
116 spondyloarthropathy 10.1 IL4 IL10 CCR6
117 penicillin allergy 10.1 IL4 IL13 IL10
118 allergic bronchopulmonary aspergillosis 10.1 IL5 IL4 IL10
119 bullous pemphigoid 10.1 IL5 IL4 IL13
120 exanthema subitum 10.1 CD40LG CD4
121 vasomotor rhinitis 10.1 IL5 CD40LG
122 aphthous stomatitis 10.1 IL5 IL4 IL10
123 west nile encephalitis 10.1 CD40LG CD4
124 vaginitis 10.1 IL10 CD4 CCR6
125 autoimmune peripheral neuropathy 10.1 CD40LG CD4
126 central nervous system hematologic cancer 10.1 IL10 CD4 CCR6
127 congenital syphilis 10.1 CD40LG CD4
128 listeriosis 10.1 IL10 CD4 CCR6
129 pustulosis of palm and sole 10.1 CRP CCR6
130 granulomatous dermatitis 10.1 CD40LG CD4
131 secondary syphilis 10.1 CD40LG CD4
132 anus disease 10.1 IL10 CD4 CCR6
133 pustulosis palmaris et plantaris 10.1 IL5 CD40LG CCR6
134 invasive aspergillosis 10.1 IL10 CD4 CCR6
135 toxic megacolon 10.1 CRP CCR6
136 ileitis 10.1 IL10 CD4 CCR6
137 mycosis fungoides 10.1 IL5 IL4 CCR6
138 rheumatoid arthritis interstitial lung disease 10.1 CRP CD4
139 west nile fever 10.1 CD40LG CD4
140 osteomyelitis 10.1 IL4 IL13 IL10
141 salmonellosis 10.1 IL10 CD4 CCR6
142 pericardial tuberculosis 10.1 CRP CD4
143 splenic sequestration 10.1 CD40LG CD4
144 sialadenitis 10.1
145 paralytic poliomyelitis 10.1 CD40LG CD4
146 metal allergy 10.1 IL4 IL10 CD4
147 lymphosarcoma 10.1
148 pyomyositis 10.1 CRP CD4
149 corneal disease 10.1 IL10 CD4 CCR6
150 breast abscess 10.1 CRP CD4
151 cutaneous t cell lymphoma 10.1 IL5 IL4 CCR6
152 fibrosis of extraocular muscles, congenital, 1 10.1
153 thrombocytopenia 10.1
154 b-cell lymphoma 10.1
155 myelitis 10.1 IL10 CD40LG CCR6
156 autoimmune neuropathy 10.1 CD40LG CD4
157 alopecia areata 10.1 IL4 IL13 IL10
158 drug-induced lupus erythematosus 10.1 IL4 IL10 CD4
159 nocardiosis 10.1 CRP CD4
160 arachnoiditis 10.1 CRP CD4
161 acute interstitial pneumonia 10.1 CRP CD4
162 evans' syndrome 10.0 IL10 CD40LG CCR6
163 coccidioidomycosis 10.0 CD40LG CD4 CCR6
164 acute disseminated encephalomyelitis 10.0 IL10 CD40LG CCR6
165 chancroid 10.0 CD40LG CD4 CCR6
166 blastomycosis 10.0 CD40LG CD4 CCR6
167 adenoid hypertrophy 10.0 CD40LG CD4
168 neurosarcoidosis 10.0 CRP CD4
169 esophagitis, eosinophilic, 1 10.0 IL5 IL4 IL13 CCR6
170 central nervous system lymphoma 10.0 IL10 CXCR5 CCR6
171 posterior uveitis 10.0 IL5 IL4 IL13 CCR6
172 childhood type dermatomyositis 10.0 CXCR5 CD4 CCR6
173 retinal vasculitis 10.0 CD40LG CD4 CCR6
174 autoimmune disease of urogenital tract 10.0 CD40LG CD4 CCR6
175 pulmonary eosinophilia 10.0 IL5 IL4 IL13 CCR6
176 tularemia 10.0 CD40LG CD4 CCR6
177 japanese spotted fever 10.0 CRP CD40LG
178 norwegian scabies 10.0 IL5 CD40LG CD4
179 histoplasmosis 10.0 CD40LG CD4 CCR6
180 goodpasture syndrome 10.0 CD40LG CD4 CCR6
181 african tick-bite fever 10.0 IL13 IL10 CD40LG
182 immunoglobulin alpha deficiency 10.0 CD40LG CD4 CCR6
183 anemia, autoimmune hemolytic 10.0 CD40LG CD4 CCR6
184 t cell deficiency 10.0 CD40LG CD4 CCR6
185 oral tuberculosis 10.0 CRP CD4
186 echinococcosis 10.0 IL5 IL10 CD40LG
187 mite infestation 10.0 IL5 CD40LG CD4
188 progressive multifocal leukoencephalopathy 10.0 CD40LG CD4 CCR6
189 chagas disease 10.0 IL4 IL10 CD4
190 splenic abscess 10.0 CRP CD40LG
191 ecthyma 10.0 CRP CD40LG
192 thymus gland disease 10.0 CD40LG CD4 CCR6
193 thymus cancer 10.0 CD40LG CD4 CCR6
194 thrombocytopenic purpura, autoimmune 10.0 CD40LG CD4 CCR6
195 lipoid nephrosis 10.0 IL13 IL10 CD40LG
196 acalculous cholecystitis 10.0 CRP CD40LG
197 myocarditis 10.0 IL4 IL10 CD40LG
198 mature b-cell neoplasm 10.0 CD40LG CD4 CCR6
199 epiglottitis 10.0 CRP CD40LG
200 viral laryngitis 10.0 CRP CD40LG
201 monoclonal gammopathy of uncertain significance 10.0 SLAMF7 CD40LG CCR6
202 q fever 10.0 IL4 IL10 CD40LG
203 lymphopenia 10.0 IL4 IL10 CCR6
204 eye lymphoma 10.0 IL10 CXCR5 CD4
205 colitis 10.0 IL4 IL13 IL10 CCR6
206 perinatal necrotizing enterocolitis 10.0 IL10 CRP CCR6
207 subacute bacterial endocarditis 10.0 CRP CD40LG
208 aspergillosis 10.0 IL5 IL4 IL10 CCR6
209 conjunctivitis 10.0 IL5 IL4 IL13 IL10
210 cutaneous leishmaniasis 10.0 IL5 IL4 IL13 IL10
211 folliculitis 10.0 IL5 IL4 CD4 CCR6
212 elephantiasis 10.0 IL5 IL4 IL13 IL10
213 idiopathic neutropenia 10.0 IL10 CD40LG
214 amebiasis 10.0 IL4 CD40LG CD4
215 hyper ige syndrome 10.0 IL4 IL13 IL10 CCR6
216 acute orbital inflammation 10.0 KNTC1 CRP CD4
217 ornithosis 10.0 CRP CD40LG
218 selective immunoglobulin deficiency disease 10.0 SLAMF7 CD40LG
219 late congenital syphilis 9.9 CRP CD40LG
220 bacterial sepsis 9.9 IL10 CRP CCR6
221 loiasis 9.9 IL5 IL4 IL13 IL10
222 mucormycosis 9.9 CRP CD4 CCR6
223 pfeiffer syndrome 9.9 CD40LG CD4 CCR6
224 sporotrichosis 9.9 IL10 CD40LG CD4
225 bacterial conjunctivitis 9.9 CRP CD40LG
226 chorioretinitis 9.9 IL10 CD40LG CD4
227 splenic infarction 9.9 CRP CD40LG
228 choroiditis 9.9 IL10 CD40LG CD4
229 urinary schistosomiasis 9.9 IL5 IL4 IL13 IL10
230 reticulum cell sarcoma 9.9
231 human immunodeficiency virus type 1 9.9
232 nodal marginal zone lymphoma 9.9
233 mumps 9.9
234 arthropathy 9.9
235 pancreatitis 9.9
236 lupus erythematosus 9.9
237 splenomegaly 9.9
238 warthin tumor 9.9
239 bone marrow cancer 9.9 CD40LG CD4 CCR6
240 congenital toxoplasmosis 9.9 IL10 CD40LG CD4
241 spondylitis 9.9 IL10 CRP CCR6
242 ige responsiveness, atopic 9.9 IL5 IL4 IL13 IL10
243 esophagitis 9.9 IL5 IL4 IL13 IL10
244 milk allergy 9.9 IL5 IL4 IL13 IL10
245 pemphigus 9.9 IL4 IL10 CD40LG
246 gastric lymphoma 9.9
247 mastitis 9.9
248 macroglobulinemia 9.9
249 amyloidosis 9.9
250 allergic conjunctivitis 9.9 IL5 IL4 IL13 IL10
251 cysticercosis 9.9 IL10 CD40LG CD4
252 reactive arthritis 9.9 IL10 CRP CCR6
253 cytomegalovirus retinitis 9.9 IL10 CD40LG CD4
254 mulchandani-bhoj-conlin syndrome 9.9 CXCR5 CD40LG CCR6
255 autoimmune hepatitis 9.9 IL4 IL10 CD40LG
256 tenosynovitis 9.9 CRP CD40LG
257 hashimoto thyroiditis 9.9 IL5 IL4 IL10
258 lymphoma, hodgkin, classic 9.9
259 pituitary hormone deficiency, combined, 2 9.9
260 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
261 diffuse large b-cell lymphoma 9.9
262 mantle cell lymphoma 9.9
263 marginal zone b-cell lymphoma 9.9
264 mononeuropathy 9.9
265 sclerosing cholangitis 9.9
266 hypothyroidism 9.9
267 prostatitis 9.9
268 cystadenoma 9.9
269 epidermolysis bullosa 9.9
270 hyperglobulinemic purpura 9.9
271 plasmacytoma 9.9
272 epidermolysis bullosa dystrophica 9.9
273 juvenile rheumatoid arthritis 9.9
274 diabetes insipidus 9.9
275 allergic angiitis 9.9
276 food allergy 9.9 IL5 IL4 IL13 IL10
277 chronic fatigue syndrome 9.9 IL5 IL4 IL13 IL10
278 maxillary sinusitis 9.9 CRP CD40LG
279 filariasis 9.9 IL5 IL10 CRP
280 myasthenia gravis 9.9 IL4 IL10 CD40LG
281 allergic asthma 9.9 IL5 IL4 IL13 IL10
282 pleural disease 9.9 CRP CD4 CCR6
283 gallbladder disease 9.9 IL10 CRP CCR6
284 inclusion body myopathy with paget disease of bone and frontotemporal dementia 9.9 IL10 CD40LG CD4
285 autoimmune disease of eyes, ear, nose and throat 9.9 IL4 IL10 CD4 CCR6
286 thyroid gland disease 9.9 CRP CD4 CCR6
287 kwashiorkor 9.9 CRP CD4
288 bronchiolitis obliterans 9.9 IL13 IL10 CRP
289 autoimmune gastritis 9.9 IL4 IL10 CD4 CCR6
290 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 IL4 IL10 CD4 CCR6
291 lacrimal apparatus disease 9.9 IL4 IL10 CD4 CCR6
292 hydrops of gallbladder 9.9 CRP CD40LG
293 croup 9.9 CRP CD40LG
294 hypotrichosis 1 9.9 IL4 IL10 CD4 CCR6
295 pulmonary tuberculosis 9.9 IL4 IL10 CRP
296 pulmonary edema 9.9 IL13 IL10 CRP
297 intraocular lymphoma 9.9 IL10 CXCR5
298 chediak-higashi syndrome 9.9 IL4 IL10 CD4 CCR6
299 pyuria 9.9 CRP CD40LG
300 papilloma 9.9 IL4 CD4 CCR6
301 mitral valve disease 9.9 IL4 IL10 CRP
302 central retinal artery occlusion 9.9 CRP CD40LG
303 nickel allergic contact dermatitis 9.9 IL5 IL4 IL10 CD4
304 allergic contact dermatitis 9.9 IL5 IL4 IL10 CD4
305 contact dermatitis 9.9 IL5 IL4 IL10 CD4
306 chorioamnionitis 9.9 IL4 IL10 CRP
307 hypopyon 9.9 IL10 CRP CD4
308 klebsiella pneumonia 9.9 CRP CD40LG CCR6
309 smoldering myeloma 9.9 SLAMF7 CD40LG
310 chronic orbital inflammation 9.9 KNTC1 CRP CD40LG
311 oral cavity cancer 9.9 IL4 CD40LG CCR6
312 human immunodeficiency virus infectious disease 9.9 IL4 IL10 CD4 CCR6
313 acute myocarditis 9.9 IL10 CRP CD4
314 pyelitis 9.9 CRP CD40LG CCR6
315 hypersensitivity reaction type iii disease 9.9 CRP CD40LG CCR6
316 periodontitis 9.8 IL4 IL10 CRP
317 extrapulmonary tuberculosis 9.8 IL10 CRP CD4
318 hepatic vascular disease 9.8 CRP CD40LG CCR6
319 peritonitis 9.8 IL4 IL10 CRP
320 pyoderma 9.8 CRP CD40LG CCR6
321 collagen disease 9.8 CRP CD40LG CCR6
322 retinitis pigmentosa 46 9.8 IL4 CD4
323 limited scleroderma 9.8 CRP CD40LG CCR6
324 typhoid fever 9.8 CRP CD40LG CCR6
325 monkeypox 9.8 CD40LG CD4
326 bullous skin disease 9.8 IL5 CD40LG CD4 CCR6
327 spondyloarthropathy 1 9.8 CRP CD40LG CCR6
328 candidiasis 9.8 IL4 IL10 CD40LG CCR6
329 enthesopathy 9.8 CRP CCR6
330 diphtheria 9.8 IL5 IL4 IL13 CD40LG
331 secondary progressive multiple sclerosis 9.8 IL4 IL10 CD40LG CCR6
332 scleritis 9.8 IL5 IL4 CRP CCR6
333 biliary tract disease 9.8 CRP CD40LG CCR6
334 relapsing-remitting multiple sclerosis 9.8 IL4 IL10 CD40LG CCR6
335 paracoccidioidomycosis 9.8 IL5 IL4 IL10 CD40LG
336 dermatitis herpetiformis 9.8 IL5 IL4 IL10 CD40LG
337 yellow fever 9.8 IL5 IL4 CRP CCR6
338 immunodeficiency with hyper-igm, type 1 9.8 IL4 CD40LG CD4 CCR6
339 rubella 9.8 IL5 IL4 IL10 CD40LG
340 toxoplasmosis 9.8 IL5 IL4 IL10 CD40LG
341 neuroretinitis 9.8 CRP CD40LG CD4
342 meningovascular neurosyphilis 9.8 CRP CD40LG CD4
343 viral exanthem 9.8 CRP CD40LG CD4
344 tertiary syphilis 9.8 CRP CD40LG CD4
345 optic papillitis 9.8 CRP CD40LG CD4
346 opportunistic bacterial infectious disease 9.8 CRP CD40LG CD4
347 gastrointestinal tuberculosis 9.8 CRP CD40LG CD4
348 tuberculoid leprosy 9.8 IL10 CD40LG CD4 CCR6
349 cerebritis 9.8 CRP CD40LG CD4
350 granulomatous hepatitis 9.8 CRP CD40LG CD4
351 primary thrombocytopenia 9.8 IL10 CD40LG CD4 CCR6
352 scrub typhus 9.8 IL10 CRP CD40LG
353 mononeuritis of upper limb and mononeuritis multiplex 9.8 CRP CD40LG CD4
354 dengue hemorrhagic fever 9.8 IL4 IL13 IL10 CD40LG
355 cat-scratch disease 9.8 CRP CD40LG CD4
356 autoimmune disease of peripheral nervous system 9.8 IL10 CD40LG CD4 CCR6
357 aortitis 9.8 CRP CD40LG CD4
358 bartonellosis 9.8 CRP CD40LG CD4
359 mastoiditis 9.8 CRP CD40LG CD4
360 abdominal tuberculosis 9.8 CRP CD40LG CD4
361 cervical adenitis 9.8 CRP CD40LG CD4
362 lung abscess 9.8 CRP CD40LG CD4
363 viral encephalitis 9.8 IL10 CD40LG CD4 CCR6
364 duodenitis 9.8 CRP CD40LG CD4
365 good syndrome 9.8 CRP CD40LG CD4
366 aseptic meningitis 9.8 IL10 CRP CD40LG
367 salpingitis 9.8 CRP CD40LG CD4
368 pleural empyema 9.8 CRP CD40LG CD4
369 cryptogenic organizing pneumonia 9.8 CRP CD40LG CD4
370 cranial nerve palsy 9.8 CRP CD40LG CD4
371 epididymis disease 9.8 CRP CD40LG CD4
372 vaginal discharge 9.8 CRP CD40LG CD4
373 hantavirus hemorrhagic fever with renal syndrome 9.8 CRP CD40LG CD4
374 intermittent claudication 9.8 IL10 CRP CD40LG
375 urethritis 9.8 CRP CD40LG CD4
376 duodenal obstruction 9.8 SPINK1 CRP
377 papilledema 9.8 CRP CD40LG CD4
378 facial nerve disease 9.8 CRP CD40LG CD4
379 facial paralysis 9.8 CRP CD40LG CD4
380 peanut allergy 9.7 IL5 IL4 IL13 IL10 CCR6
381 dermatitis 9.7 IL5 IL4 IL13 IL10 CCR6
382 cholangitis, primary sclerosing 9.7 IL10 CD40LG CD4 CCR6
383 takayasu arteritis 9.7 IL10 CRP CD40LG
384 pericardium disease 9.7 CRP CD40LG CD4
385 pharyngitis 9.7 CRP CD40LG CD4
386 severe acute respiratory syndrome 9.7 IL10 CRP CD40LG
387 x-linked monogenic disease 9.7 IL10 CD40LG CD4 CCR6
388 endocardium disease 9.7 CRP CD40LG CD4
389 diarrhea 9.7 IL5 IL13 IL10 CD40LG
390 pericardial effusion 9.7 CRP CD40LG CD4
391 scarlet fever 9.7 CRP CD40LG
392 pericarditis 9.7 CRP CD40LG CD4
393 severe cutaneous adverse reaction 9.7 CRP CD40LG CD4
394 autoimmune vasculitis 9.7 IL4 CRP CD4 CCR6
395 overnutrition 9.7 IL10 CRP CCR6
396 hellp syndrome 9.7 IL10 CRP CD40LG
397 mouth disease 9.7 IL13 IL10 CRP CCR6
398 taeniasis 9.7 IL4 IL10 CD40LG CD4
399 lymphoid interstitial pneumonia 9.7 CRP CD40LG CD4
400 poliomyelitis 9.7 IL4 IL10 CD40LG CD4
401 gastroenteritis 9.7 IL5 IL4 IL10 CRP
402 gingival disease 9.7 IL10 CRP CD4 CCR6
403 vaginal disease 9.7 IL10 CRP CD4 CCR6
404 stomatitis 9.7 IL4 IL10 CD40LG CD4
405 visceral leishmaniasis 9.7 IL4 IL13 IL10 CRP
406 stomach disease 9.7 IL10 CRP CD4 CCR6
407 sezary's disease 9.7 IL5 IL4 IL10 CD4 CCR6
408 chronic mucocutaneous candidiasis 9.7 IL5 IL4 IL10 CD4 CCR6
409 cryptococcosis 9.7 IL4 IL13 IL10 CD4 CCR6
410 glucose metabolism disease 9.6 IL10 CRP CD4 CCR6
411 mucocutaneous leishmaniasis 9.6 IL5 IL4 IL13 IL10 CD4
412 acquired metabolic disease 9.6 IL10 CRP CD4 CCR6
413 filarial elephantiasis 9.6 IL5 IL4 IL13 IL10 CD4
414 intestinal disease 9.6 IL10 CRP CD4 CCR6
415 neuromyelitis optica 9.6 IL5 IL4 CRP CD40LG
416 scleral disease 9.6 CRP CD40LG CD4 CCR6
417 iritis 9.6 CRP CD40LG CD4 CCR6
418 central nervous system vasculitis 9.6 CRP CD40LG CD4 CCR6
419 common variable immunodeficiency 9.6 IL5 IL4 IL21 IL10 CD40LG
420 acute proliferative glomerulonephritis 9.6 CRP CD40LG CD4 CCR6
421 pneumocystosis 9.6 CRP CD40LG CD4 CCR6
422 cecal disease 9.6 CRP CD40LG CD4 CCR6
423 fallopian tube disease 9.6 CRP CD40LG CD4 CCR6
424 plasma protein metabolism disease 9.6 CRP CD40LG CD4 CCR6
425 autoimmune disease of cardiovascular system 9.6 CRP CD40LG CD4 CCR6
426 coronavirus infectious disease 9.6 CRP CD40LG CD4 CCR6
427 syphilis 9.6 CRP CD40LG CD4 CCR6
428 vein disease 9.6 CRP CD40LG CD4 CCR6
429 temporal arteritis 9.6 CRP CD40LG CD4 CCR6
430 cranial nerve disease 9.6 CRP CD40LG CD4 CCR6
431 schistosomiasis 9.6 IL5 IL4 IL13 IL10 CD40LG
432 blood platelet disease 9.6 CRP CD40LG CD4 CCR6
433 eosinophilic meningitis 9.6 IL5 IL4 IL13 IL10 CD40LG
434 drug allergy 9.6 IL5 CRP CD40LG CD4
435 bile duct disease 9.6 CRP CD40LG CD4 CCR6
436 optic nerve disease 9.5 CRP CD40LG CD4 CCR6
437 leptospirosis 9.5 IL4 IL10 CRP CD40LG
438 plasmodium falciparum malaria 9.5 IL4 IL10 CRP CD40LG
439 pelvic inflammatory disease 9.5 IL13 CRP CD40LG CD4
440 toxic shock syndrome 9.5 IL4 IL10 CRP CD40LG
441 burkitt lymphoma 9.5 IL4 IL10 CXCR5 CD40LG
442 viral hepatitis 9.5 IL4 IL10 CRP CD40LG
443 fungal meningitis 9.5 IL4 IL10 CD40LG CD4 CCR6
444 lichen disease 9.5 IL4 IL10 CD40LG CD4 CCR6
445 genital herpes 9.5 IL4 IL10 CD40LG CD4 CCR6
446 herpangina 9.5 IL4 IL10 CD40LG CD4 CCR6
447 autoimmune disease of skin and connective tissue 9.5 IL4 IL10 CD40LG CD4 CCR6
448 autoimmune disease of endocrine system 9.5 IL4 IL10 CD40LG CD4 CCR6
449 b cell deficiency 9.5 IL4 IL10 CD40LG CD4 CCR6
450 testicular disease 9.5 IL4 IL10 CD40LG CD4 CCR6
451 hair disease 9.5 IL4 IL10 CD40LG CD4 CCR6
452 x-linked recessive disease 9.5 IL4 IL10 CD40LG CD4 CCR6
453 arthritis 9.5 IL4 IL13 IL10 CRP CCR6
454 chlamydia pneumonia 9.5 IL10 CRP CD40LG CD4
455 iridocyclitis 9.5 IL10 CRP CD40LG CD4
456 combined t cell and b cell immunodeficiency 9.5 IL4 IL10 CD40LG CD4 CCR6
457 demyelinating disease 9.5 IL4 IL10 CD40LG CD4 CCR6
458 bronchopneumonia 9.5 IL10 CRP CD40LG CD4
459 epidemic typhus 9.5 IL10 CRP CD40LG CD4
460 ulcerative colitis 9.5 IL4 IL13 IL10 CRP CCR6
461 leishmaniasis 9.5 IL5 IL4 IL13 IL10 CRP
462 proteasome-associated autoinflammatory syndrome 1 9.5 IL5 IL4 IL13 IL10 CRP
463 acute pancreatitis 9.5 SPINK1 IL10 CRP
464 vascular disease 9.5 IL10 CRP CD40LG CD4
465 egg allergy 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
466 legume allergy 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
467 fruit allergy 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
468 chronic conjunctivitis 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
469 nasal cavity disease 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
470 common cold 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
471 respiratory allergy 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
472 lipoprotein quantitative trait locus 9.4 IL10 CRP CD40LG CD4
473 allergic hypersensitivity disease 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
474 dermatitis, atopic 9.4 IL5 IL4 IL13 IL10 CD4 CCR6
475 granulomatosis with polyangiitis 9.4 IL5 CRP CD40LG CD4 CCR6
476 toxocariasis 9.3 IL5 IL4 IL10 CRP CD40LG
477 chlamydia 9.3 IL5 IL4 IL10 CRP CD40LG
478 chronic meningitis 9.3 IL5 IL13 CRP CD40LG CD4
479 mycoplasma pneumoniae pneumonia 9.3 IL4 IL13 IL10 CRP CD40LG
480 bacterial infectious disease 9.3 IL10 CRP CD40LG CD4 CCR6
481 brucellosis 9.3 IL4 IL13 IL10 CRP CD40LG
482 viral pneumonia 9.3 IL10 CRP CD40LG CD4 CCR6
483 streptococcus pneumonia 9.3 IL10 CRP CD40LG CD4 CCR6
484 pre-eclampsia 9.3 IL4 IL10 CRP CD40LG
485 panuveitis 9.3 IL10 CRP CD40LG CD4 CCR6
486 middle ear disease 9.3 IL10 CRP CD40LG CD4 CCR6
487 dysentery 9.3 IL10 CRP CD40LG CD4 CCR6
488 rectal disease 9.3 IL10 CRP CD40LG CD4 CCR6
489 spinal cord disease 9.3 IL10 CRP CD40LG CD4 CCR6
490 acute cystitis 9.3 IL10 CRP CD40LG CD4 CCR6
491 herpes zoster 9.3 IL10 CRP CD40LG CD4 CCR6
492 bacterial pneumonia 9.3 IL10 CRP CD40LG CD4 CCR6
493 blood coagulation disease 9.3 IL10 CRP CD40LG CD4 CCR6
494 leprosy 3 9.3 IL5 IL4 IL10 CD40LG CD4 CCR6
495 omenn syndrome 9.3 IL5 IL4 IL10 CD40LG CD4 CCR6
496 viral infectious disease 9.3 IL4 IL13 IL10 CD40LG CD4 CCR6
497 immune system disease 9.3 IL4 IL13 IL10 CD40LG CD4 CCR6
498 immune deficiency disease 9.3 IL4 IL13 IL10 CD40LG CD4 CCR6
499 trichinosis 9.3 IL5 IL4 IL13 IL10 CD40LG CD4
500 orchitis 9.3 IL4 IL10 CRP CD40LG CD4
501 severe combined immunodeficiency 9.2 IL5 IL4 IL21 IL13 IL10 CD4
502 kawasaki disease 9.2 IL4 IL10 CRP CD40LG CD4
503 psoriasis 9.2 IL5 IL4 IL21 IL13 IL10 CD4
504 parotid disease 9.2 SPINK1 CRP CD40LG CD4
505 psoriatic arthritis 9.1 IL4 IL13 IL10 CRP CD40LG CCR6
506 meningitis 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
507 pneumonia 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
508 urticaria 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
509 bronchitis 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
510 tetanus 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
511 otitis media 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
512 interstitial lung disease 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
513 lung disease 9.1 IL5 IL4 IL13 IL10 CRP CD40LG
514 primary biliary cirrhosis 9.1 IL5 IL4 IL10 CXCR5 CD40LG CD4
515 leukemia, chronic lymphocytic 9.1 IL4 IL10 CXCR5 CD40LG CD4 CCR6
516 intestinal schistosomiasis 9.1 IL5 IL4 IL13 IL10 CD40LG CD4
517 parasitic helminthiasis infectious disease 9.1 IL5 IL4 IL13 IL10 CD40LG CD4
518 primary systemic mycosis 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
519 chickenpox 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
520 autoimmune disease of central nervous system 9.1 IL5 IL4 IL13 IL10 CD40LG CD4
521 splenic disease 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
522 coccidiosis 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
523 meningoencephalitis 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
524 lymph node disease 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
525 hypersensitivity reaction type iv disease 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
526 autoimmune disease of gastrointestinal tract 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
527 extrinsic cardiomyopathy 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
528 uveal disease 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
529 autoimmune disease of musculoskeletal system 9.1 IL4 IL10 CRP CD40LG CD4 CCR6
530 peripheral nervous system disease 9.0 IL4 IL10 CRP CD40LG CD4 CCR6
531 asthma 9.0 IL5 IL4 IL13 IL10 CD40LG CD4
532 pulmonary disease, chronic obstructive 9.0 IL5 IL4 IL13 IL10 CRP CD4
533 pulmonary fibrosis, idiopathic 9.0 IL5 IL4 IL13 IL10 CRP CD4
534 respiratory failure 8.8 IL5 IL13 IL10 CRP CD40LG CD4
535 autoimmune disease of blood 8.8 IL5 IL4 IL10 CRP CD40LG CD4
536 commensal bacterial infectious disease 8.8 IL5 IL4 IL10 CRP CD40LG CD4
537 cellulitis 8.8 IL5 IL4 IL10 CRP CD40LG CD4
538 bone inflammation disease 8.8 IL4 IL13 IL10 CRP CD40LG CD4
539 systemic scleroderma 8.8 IL4 IL13 IL10 CRP CD40LG CD4
540 body mass index quantitative trait locus 11 8.7 IL4 IL10 CRP CD4 CCR6
541 inflammatory bowel disease 8.7 IL5 IL4 IL21 IL13 IL10 CRP
542 autoimmune disease of exocrine system 8.7 IL4 IL10 CXCR5 CRP CD40LG CD4
543 potocki-shaffer syndrome 8.7 IL4 IL10 CXCR5 CRP CD40LG CD4
544 multiple sclerosis 8.7 IL5 IL4 IL13 IL10 CXCR5 CD40LG
545 diabetes mellitus 8.6 SPINK1 IL4 IL10 CRP CD40LG CD4
546 conjunctival disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
547 nose disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
548 parasitic protozoa infectious disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
549 opportunistic mycosis 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
550 fungal infectious disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
551 paranasal sinus disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
552 bronchial disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
553 primary bacterial infectious disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
554 leukocyte disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
555 integumentary system disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
556 upper respiratory tract disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
557 behcet syndrome 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
558 diabetes mellitus, type i 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
559 skin disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
560 eye disease 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
561 malaria 8.6 IL5 IL4 IL13 IL10 CRP CD40LG
562 celiac disease 1 8.4 IL5 IL4 IL21 IL13 IL10 CRP
563 systemic lupus erythematosus 7.7 SLAMF7 IL5 IL4 IL21 IL13 IL10

Graphical network of the top 20 diseases related to Mikulicz Disease:



Diseases related to Mikulicz Disease

Symptoms & Phenotypes for Mikulicz Disease

Symptoms:

12 (showing 1, show less)
  • lumps of the face

MGI Mouse Phenotypes related to Mikulicz Disease:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CCR6 CD4 CD40LG CXCR5 IL10 IL13
2 digestive/alimentary MP:0005381 9.73 CD4 IL10 IL13 IL4 IL5 SPINK1
3 homeostasis/metabolism MP:0005376 9.7 CCR6 CD4 CD40LG CRP IL10 IL13
4 immune system MP:0005387 9.4 CCR6 CD4 CD40LG CRP CXCR5 IL10

Drugs & Therapeutics for Mikulicz Disease

Drugs for Mikulicz Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 21, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Hormones Phase 4
10 Immunologic Factors Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Methylprednisolone Acetate Phase 4
13 glucocorticoids Phase 4
14 Hormone Antagonists Phase 4
15 Immunosuppressive Agents Phase 4
16 Liver Extracts Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Immunoglobulins
19 Antibodies
20 Immunoglobulins, Intravenous
21 Immunoglobulin G

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
2 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448

Search NIH Clinical Center for Mikulicz Disease

Cochrane evidence based reviews: mikulicz' disease

Genetic Tests for Mikulicz Disease

Anatomical Context for Mikulicz Disease

MalaCards organs/tissues related to Mikulicz Disease:

40
Eye, Salivary Gland, Bone, Liver, Bone Marrow, Lung, Skin

Publications for Mikulicz Disease

Articles related to Mikulicz Disease:

(showing 91, show less)
# Title Authors PMID Year
1
Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. 61 52
28916523 2017
2
Serum immunoglobulin G4 in Sjögren's syndrome: a pilot study. 61
32062697 2020
3
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria. 61
30696319 2020
4
Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases. 61
32083541 2020
5
Mikulicz Disease. 61
31913425 2020
6
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. 61
30354922 2019
7
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. 61
29656682 2019
8
Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients. 61
30701685 2019
9
IgG4-related respiratory disease. 61
30474465 2019
10
Stage classification of IgG4-related dacryoadenitis and sialadenitis by the serum cytokine environment. 61
29385874 2018
11
Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. 61
30173184 2018
12
Estimation of proton density fat fraction of the salivary gland. 61
29376736 2018
13
Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions. 61
29207199 2018
14
Mikulicz Disease Mimicking Intraorbital Tumors. 61
28987847 2018
15
[Non-Hodgkin's lymphoma mimicking Mikulicz disease: a case report]. 61
27987516 2016
16
Gallium SPECT/CT in evaluation of IgG4-related disease: A case report and literature review. 61
27631251 2016
17
IgG4-related disease. 61
26259069 2016
18
IgG4-related hypophysitis presenting as diabetes insipidus with tubulo-interstital nephritis and mediastinal lymphadenopathy. 61
27398219 2016
19
[Review of ear and nose and throat involvement in IgG4-RD]. 61
26911076 2015
20
[112th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Recent Progress in IgG4-related Disease: IgG4-related Dacryoadenitis and Sialadenitis]. 61
30160920 2015
21
[IgG4-related Dacryoadenitis and Sialadenitis]. 61
30160881 2015
22
Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) and for differentiating it from Sjögren's syndrome (SS), with an emphasis on sonography. 61
26298875 2015
23
IgG4-related Mikulicz Disease in a 76-year-old Chinese Male: A Case Report. 61
24432837 2015
24
IgG4 related disease of the head and neck. 61
25804380 2015
25
Diagnostic criteria for IgG4-related ophthalmic disease. 61
25392273 2015
26
Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment. 61
24907151 2015
27
IgG4-related skin disease. 61
25065694 2014
28
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. 61
24593171 2014
29
¹⁸F-FDG PET-CT usefulness in extra-pancreatic involvement in IgG4 related diseases. 61
24630373 2014
30
Mechanisms and assessment of IgG4-related disease: lessons for the rheumatologist. 61
24296677 2014
31
IgG4-related multiorgan disease: report of the first autopsy case. 61
23645656 2013
32
Rare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry. 61
23146570 2013
33
IgG4-related disease in the head and neck. 61
23068303 2012
34
"Quasi-symmetric" FDG avidity of bilateral salivary glands in Mikulicz disease yielding false-positive staging in lung cancer. 61
22996254 2012
35
IgG4-related disease of the head and neck: CT and MR imaging manifestations. 61
23150850 2012
36
Autoimmune pancreatitis that developed over a 3-month observation period for IgG4-related dacryoadenitis and sialadenitis. 61
26182321 2012
37
Utility of FDG PET/CT in IgG4-related systemic disease. 61
22119099 2012
38
Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. 61
21898360 2012
39
[Usefulness of measuring serum IgG4 level as diagnostic and treatment marker in IgG4-related disease]. 61
22374440 2012
40
Jan Mikulicz-Radecki (1850-1905): his impact on modern medicine. 61
25872240 2012
41
[A case of IgG4-related disease with marked thickening of the bronchial wall]. 61
22352056 2011
42
Cytohistological features of rhinoscleroma. 61
22234117 2011
43
Connective tissue diseases: Immune responses in Mikulicz disease differ from those in SS. 61
21971284 2011
44
Membranous nephropathy associated with IgG4-related disease. 61
21658826 2011
45
IgG4-associated sialadenitis. 61
21124091 2011
46
Clinicopathologic similarities between Mikulicz disease and Küttner tumor. 61
20015799 2010
47
[Clinical analysis of 11 cases of Mikulicz disease in the salivary glands]. 61
21176583 2010
48
[The first experience of using rituximab in Mikulicz disease]. 61
20731115 2010
49
Highly active state of autoimmune pancreatitis with mikulicz disease. 61
19904224 2010
50
[Autoimmune pancreatitis]. 61
19860211 2009
51
Sonographic diagnosis for Mikulicz disease. 61
19451003 2009
52
F-18 FDG PET-CT findings in Mikulicz disease and systemic involvement of IgG4-related lesions. 61
19352281 2009
53
Diffuse periairway thickening in patients with Mikulicz disease. 61
18728553 2008
54
[Multicentric Castleman disease-like case characterized by lymphadenopathy and polyclonal hypergammaglobulinemia associated with so-called Mikulicz disease]. 61
17441481 2007
55
Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature. 61
14716060 2003
56
[Kimura disease]. 61
10230233 1999
57
[Mikulicz disease as the beginning of AIDS]. 61
8037370 1994
58
Mikulicz syndrome and disease: 2 case reports highlighting the difference. 61
8475708 1993
59
[Diagnosis of periorbital diseases by means of ultrasound]. 61
1916424 1991
60
[Rare from of Mikulicz' disease]. 61
4013308 1985
61
[Sialography (the fourth report)--Sjögren syndrome and Mikulicz disease]. 61
6737767 1984
62
Mikulicz disease of a minor salivary gland. 61
280669 1978
63
[Mikulicz' disease, rheumatoid arthritis and cutaneous-muscular microangiopathy]. 61
609816 1977
64
Mikulicz disease and subsequent lupus erythematosus development. 61
576964 1977
65
Benign lymphoepithelial lesions of the salivary glands. 61
1173025 1975
66
[Mikulicz' disease]. 61
4523031 1973
67
[Some specific features of the clinical picture, diagnosis and treatment in cases of the salivary and lacrimal gland disease with Mikulicz' disease]. 61
4516270 1973
68
[Epithelial tumors of the salivary glands containing lymphatic tissue. II. Mikulicz' disease]. 61
4702235 1973
69
Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). 61
4943296 1971
70
[A rare clinical picture of Mikulicz' disease]. 61
5280626 1971
71
[Results of radiotherapy in Mikulicz' disease]. 61
5441642 1970
72
[Mikulicz' disease]. 61
5277398 1969
73
[A case of Mikulicz disease in a 7-year-old girl]. 61
5252352 1969
74
[Mikulicz disease in the course of senile arthropathy]. 61
5246719 1968
75
[Symptomatology of Mikulicz' disease]. 61
5728957 1968
76
[On the problem of Mikulicz' disease]. 61
5688450 1968
77
[STUDIES ON MIKULICZ' DISEASE AND S'J'OGREN'S SYNDROME]. 61
14159673 1964
78
[CONSIDERATIONS ON A CASE OF MIKULICZ' DISEASE]. 61
14118457 1963
79
[Salivary gland diseases. I. The use of Co60 in Mikulicz' disease. II. Submaxillary gland disease and its therapy]. 61
13718373 1961
80
The parotid gland in Mikulicz disease and Sjogren's syndrome. 61
13713214 1960
81
The parotid gland in Mikulicz disease and Sjogren's syndrome. 61
13713215 1960
82
[Case of Mikulicz' disease]. 61
13621542 1958
83
[Comparative studies on the salivary and lacrimal glands in connection with the pathogenesis of Sjögren syndrome and Mikulicz disease]. 61
13530661 1957
84
Benign lymphoepithelial lesion of the parotid gland adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, Mikulicz disease. 61
12998015 1952
85
[Mikulicz disease and its atypical localizations]. 61
13041848 1952
86
[Mikulicz disease]. 61
12998075 1952
87
[Differentialdiagnose and pathogenesis of Mikulicz disease; casuistic under consideration of changes in bone marrow and serum protein]. 61
12976227 1952
88
Mikulicz' disease: report of a case of one week's duration. 61
14908801 1952
89
Mikulicz' disease and Mikulicz' syndrome. 61
18119668 1949
90
A CASE OF MIKULICZ' DISEASE. 61
18168915 1930
91
LYMPHOID HYPERPLASIA OF LACRYMAL AND SALIVARY GLANDS: MIKULICZ' DISEASE. 61
17865927 1928

Variations for Mikulicz Disease

Expression for Mikulicz Disease

Search GEO for disease gene expression data for Mikulicz Disease.

Pathways for Mikulicz Disease

Pathways related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 32, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 SLAMF7 IL5 IL4 IL13 IL10 CRP
2
Show member pathways
13.66 IL5 IL4 IL21 IL13 IL10 CXCR5
3
Show member pathways
13.5 IL5 IL4 IL21 IL13 IL10 CXCR5
4
Show member pathways
13.22 IL5 IL4 IL13 IL10 CD40LG CD4
5
Show member pathways
13.2 IL5 IL4 IL21 IL13 IL10 CXCR5
6
Show member pathways
13.04 IL5 IL4 IL21 IL13 IL10 CXCR5
7
Show member pathways
12.6 IL5 IL4 IL21 IL13 IL10 CXCR5
8
Show member pathways
12.51 IL4 IL10 CD40LG CD4
9
Show member pathways
12.51 IL5 IL4 IL10 CD40LG CD4
10
Show member pathways
12.45 IL5 IL4 IL21 IL13 IL10 CD4
11 12.44 IL4 IL10 CXCR5 CD40LG
12
Show member pathways
12.35 IL5 IL4 IL21 IL13 IL10
13
Show member pathways
12.15 IL5 IL4 IL13 IL10
14 11.91 IL5 IL4 IL10 CD4
15 11.88 IL4 IL13 IL10
16
Show member pathways
11.84 IL21 IL10 CD4
17 11.79 IL5 IL4 CD4
18
Show member pathways
11.75 IL4 IL21 CXCR5 CD4
19 11.7 IL5 IL4 IL13
20
Show member pathways
11.66 IL5 IL4 CD40LG
21 11.57 IL5 IL4 IL13
22 11.56 IL5 IL4 IL10 CD40LG
23 11.46 IL4 IL13 IL10
24 11.28 IL5 IL4 CD40LG
25 11.26 IL5 IL4 IL13
26 11.22 IL5 IL4 IL13 IL10 CD4
27 11.08 IL5 IL4 IL13 IL10
28 11.07 IL5 IL4 IL13 IL10 CXCR5 CD4
29 10.9 IL5 IL4 IL21 IL13 IL10 CD40LG
30 10.88 IL4 IL21
31 10.82 IL5 IL4 IL13 IL10 CD4
32 10.73 IL5 IL4 IL13

GO Terms for Mikulicz Disease

Cellular components related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 SPINK1 IL5 IL4 IL21 IL13 IL10
2 external side of plasma membrane GO:0009897 9.35 IL13 CXCR5 CD40LG CD4 CCR6
3 extracellular space GO:0005615 9.23 SPINK1 IL5 IL4 IL21 IL13 IL10

Biological processes related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 19, show less)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.01 IL5 IL4 IL21 IL10 CXCR5 CD40LG
2 inflammatory response GO:0006954 9.87 IL5 IL13 CRP CD40LG
3 negative regulation of inflammatory response GO:0050728 9.75 IL4 IL13 IL10
4 B cell differentiation GO:0030183 9.67 IL4 IL10 CD40LG
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IL4 IL21 IL13
6 cytokine-mediated signaling pathway GO:0019221 9.65 IL5 IL4 IL13 IL10 CD4
7 positive regulation of macrophage activation GO:0043032 9.58 IL13 IL10
8 macrophage activation GO:0042116 9.56 IL4 IL13
9 positive regulation of interleukin-10 secretion GO:2001181 9.55 IL4 IL13
10 positive regulation of mast cell degranulation GO:0043306 9.54 IL4 IL13
11 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 IL4 IL10
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL4 IL10
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL4 IL13 IL10
14 type 2 immune response GO:0042092 9.46 IL4 IL10
15 positive regulation of T cell proliferation GO:0042102 9.46 IL4 IL21 CD40LG CD4
16 regulation of isotype switching GO:0045191 9.43 IL4 IL10
17 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL4 IL13
18 immune response GO:0006955 9.28 IL5 IL4 IL21 IL13 IL10 CXCR5
19 positive regulation of B cell proliferation GO:0030890 9.26 IL5 IL4 IL21 IL13

Molecular functions related to Mikulicz Disease according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL4 IL21 IL13
2 cytokine activity GO:0005125 9.1 IL5 IL4 IL21 IL13 IL10 CD40LG

Sources for Mikulicz Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....