MCID: MLD002
MIFTS: 33

Mild Pre-Eclampsia

Categories: Cardiovascular diseases

Aliases & Classifications for Mild Pre-Eclampsia

MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 54 15 71
Mild Toxemia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 34 642.40
UMLS 71 C0156664 C0269658 C0866321

Summaries for Mild Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to placental abruption and severe pre-eclampsia. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Signaling events mediated by VEGFR1 and VEGFR2 and HIF-1-alpha transcription factor network. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and endothelial.

Related Diseases for Mild Pre-Eclampsia

Diseases related to Mild Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 placental abruption 30.1 PGF PAPPA FLT1 ENG
2 severe pre-eclampsia 29.6 VEGFA VCAM1 PGF PAPPA LGALS13
3 hellp syndrome 29.4 VEGFA PGF LGALS13 FLT1 ENG
4 eclampsia 29.2 VEGFA STOX1 PGF PAPPA LGALS13 FLT1
5 pre-eclampsia 28.5 XDH VEGFA VCAM1 STOX1 SOD1 PGF
6 anoxia 10.3 XDH SOD1
7 pyridoxine deficiency anemia 10.3 VCAM1 IGFBP1
8 mammographic density 10.3 IGFBP1 ESR1
9 late congenital syphilis 10.2 FLT1 ENG
10 early congenital syphilis 10.2 FLT1 ENG
11 placenta praevia 10.1 PGF PAPPA
12 proteinuria, chronic benign 10.1
13 chromosomal duplication syndrome 10.1 SOD1 PAPPA MIR1306
14 oligohydramnios 10.0 PGF PAPPA MIR517A
15 cardiovascular system disease 10.0 XDH VCAM1 SOD1 IGFBP1 ESR1
16 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.0
17 47,xyy 10.0
18 gestational diabetes 10.0 PGF PAPPA IGFBP1
19 patau syndrome 10.0 PGF PAPPA LGALS13
20 eales disease 10.0 VEGFA SOD1
21 buerger disease 9.9 VEGFA VCAM1
22 microcystic meningioma 9.9 VEGFA FLT1
23 lipodermatosclerosis 9.9 VEGFA FLT1
24 uterine benign neoplasm 9.9 VEGFA IGFBP1 ESR1
25 severe nonproliferative diabetic retinopathy 9.9 VEGFA PGF
26 angiokeratoma circumscriptum 9.9 VEGFA FLT1
27 primary peritoneal carcinoma 9.9 VEGFA MIR195
28 primary cutaneous b-cell lymphoma 9.9 VEGFA FLT1
29 vitreous detachment 9.9 VEGFA PGF
30 juvenile nasopharyngeal angiofibroma 9.8 VEGFA ESR1 ENG
31 neonatal anemia 9.8 PGF PAPPA FLT1 ENG
32 twin-to-twin transfusion syndrome 9.8 PGF PAPPA FLT1 ENG
33 breast carcinoma in situ 9.8 VEGFA FLT1 ESR1
34 retinal perforation 9.8 VEGFA PGF
35 osteonecrosis 9.8 VEGFA ESR1 ENG
36 cancer-associated retinopathy 9.8 VEGFA PGF FLT1
37 hypertensive encephalopathy 9.8 VEGFA PGF FLT1
38 epithelioid hemangioendothelioma 9.8 VEGFA PGF FLT1
39 blood group, globoside system 9.8 VEGFA PGF FLT1
40 kuhnt-junius degeneration 9.8 VEGFA PGF FLT1
41 neovascular glaucoma 9.8 VEGFA PGF FLT1
42 endophthalmitis 9.8 VEGFA PGF FLT1
43 retinal vascular occlusion 9.8 VEGFA PGF FLT1
44 peripheral artery disease 9.8 VEGFA VCAM1 ENG
45 intussusception 9.8 VEGFA PGF FLT1
46 macular retinal edema 9.8 VEGFA PGF FLT1
47 acute mountain sickness 9.8 VEGFA FLT1
48 peripartum cardiomyopathy 9.8 VEGFA PGF FLT1
49 retinal artery occlusion 9.8 VEGFA PGF FLT1
50 glomeruloid hemangioma 9.8 VEGFA FLT1 ENG

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia

Symptoms & Phenotypes for Mild Pre-Eclampsia

Drugs & Therapeutics for Mild Pre-Eclampsia

Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
3 Citrate Phase 2, Phase 3
4 Phosphodiesterase Inhibitors Phase 2, Phase 3
5 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
6 Vasodilator Agents Phase 2, Phase 3
7 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
8 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial Unknown status NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
3 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370

Search NIH Clinical Center for Mild Pre-Eclampsia

Genetic Tests for Mild Pre-Eclampsia

Anatomical Context for Mild Pre-Eclampsia

MalaCards organs/tissues related to Mild Pre-Eclampsia:

40
Placenta, Liver, Endothelial, Neutrophil, Retina, Adipocyte, Thyroid

Publications for Mild Pre-Eclampsia

Articles related to Mild Pre-Eclampsia:

(show top 50) (show all 201)
# Title Authors PMID Year
1
Erythrocyte antioxidant enzymes and plasma antioxidant vitamins in Sudanese women with pre-eclampsia. 61 54
20143973 2010
2
[Expression of transforming growth factor-beta 1, vascular cell adhesion molecule-1 and endothelium-selectin in placenta of patients with pre-eclampsia]. 54 61
17083832 2006
3
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. 54 61
15248180 2004
4
Serum levels of insulin, IGF-1, and IGFBP-1 in pre-eclampsia and eclampsia. 61 54
15001368 2004
5
Vascular cell adhesion molecule-1 (VCAM-1) and leukocyte activation in pre-eclampsia and eclampsia. 61 54
9856316 1998
6
Peripartum management of hypertension: a position paper of the ESC Council on Hypertension and the European Society of Hypertension. 61
31841131 2020
7
Immediate versus delayed induction of labour in hypertensive disorders of pregnancy: a systematic review and meta-analysis. 61
33243171 2020
8
CA125 levels in pregnancy: A case-control study amongst pregnant women in Aminu Kano teaching hospital, North-West Nigeria. 61
33154285 2020
9
CD25+ FOXP3+ and CD4+ CD25+ cells distribution in decidual departments of women with severe and mild pre-eclampsia: Comparison with healthy pregnancies. 61
32485016 2020
10
Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study. 61
32646363 2020
11
Impact of Hypertension and Preeclampsia Intervention Trial At Near Term-I (HYPITAT-I) on obstetric management and outcome in The Netherlands. 61
31486156 2020
12
Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia. 61
29455633 2019
13
Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis. 61
30630878 2019
14
Sex Differences in Nutrition, Growth, and Metabolism in Preterm Infants. 61
30792973 2019
15
Correlation analysis of levels of inflammatory cytokines and nitric oxide in peripheral blood with urine proteins and renal function in patients with gestational hypertension. 61
30651847 2019
16
The clinical prognostic significance of myocardial performance index (MPI) in stable placental-mediated disease. 61
30152840 2018
17
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. 61
30158032 2018
18
Analgesic effect of adding magnesium sulfate to epidural levobupivacaine in patients with pre-eclampsia undergoing elective cesarean section. 61
30386015 2018
19
Hypertensive pregnancy complications in women with epilepsy and antiepileptic drugs: a population-based cohort study of first pregnancies in Norway. 61
29691249 2018
20
Study on the correlation between adipocyte fatty-acid binding protein, glucolipid metabolism, and pre-eclampsia. 61
29316087 2018
21
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. 61
29367581 2018
22
Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study. 61
29186464 2017
23
Clinical practice patterns on the use of magnesium sulphate for treatment of pre-eclampsia and eclampsia: a multi-country survey. 61
27885772 2017
24
A systematic review and meta-analysis of hypocalciuria in pre-eclampsia. 61
28369876 2017
25
Is mean platelet volume a better biomarker in pre-eclampsia? 61
28422358 2017
26
Maternal circulating levels of transforming growth factor-β superfamily and its soluble receptors in hypertensive disorders of pregnancy. 61
28281288 2017
27
[Effect of microRNA-106b on the invasion and proliferation of trophoblasts through targeting MMP-2]. 61
28545271 2017
28
Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes. 61
28501282 2017
29
Association of biochemical markers with the severity of pre-eclampsia. 61
28099727 2017
30
Impact of Road Traffic Pollution on Pre-eclampsia and Pregnancy-induced Hypertensive Disorders. 61
27648591 2017
31
Time from pre-eclampsia diagnosis to delivery affects future health prospects of children. 61
28421136 2017
32
Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term. 61
28106904 2017
33
Diagnosis of pre-eclampsia and assessment of severity through examination of the placenta with acoustic radiation force impulse elastography. 61
27452611 2016
34
Potential for task-sharing to Lady Health Workers for identification and emergency management of pre-eclampsia at community level in Pakistan. 61
27719680 2016
35
Prospective cohort study of persistent hypertension following pre-eclampsia at Medani Hospital, Sudan. 61
26975905 2016
36
Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia. 61
27039049 2016
37
Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. 61
26874361 2016
38
Nucleated Red Blood Cell Count in Maternal Peripheral Blood and Hypertensive Disorders in Pregnant Women. 61
26897268 2016
39
Association between polymorphisms in IL-27 gene and pre-eclampsia. 61
26654512 2016
40
Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? 61
26955767 2016
41
Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. 61
26177586 2015
42
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. 61
25833188 2015
43
Long-term maternal atherosclerotic morbidity in women with pre-eclampsia. 61
25564558 2015
44
Detection of early left ventricular dysfunction in patients with maternal placental syndrome using tissue Doppler and strain rate imaging. 61
25629901 2015
45
The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia. 61
25445606 2014
46
An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy. 61
25481580 2014
47
Concentrations of human chorionic gonadotrophin in very early pregnancy and subsequent pre-eclampsia: a cohort study. 61
24722241 2014
48
[Factors associated with mode of delivery in women with pre-eclampsia]. 61
25099465 2014
49
A simple method for the assessment of arterial stiffness in pre-eclamptic patients. 61
24786588 2014
50
[Is there a relationship between pregnancy induced hypertension and obstructive sleep apnea? Case report]. 61
24615199 2014

Variations for Mild Pre-Eclampsia

Expression for Mild Pre-Eclampsia

Search GEO for disease gene expression data for Mild Pre-Eclampsia.

Pathways for Mild Pre-Eclampsia

GO Terms for Mild Pre-Eclampsia

Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 XDH VEGFA SOD1 PSG9 PSG11 PGF
2 extracellular space GO:0005615 9.36 XDH VEGFA VCAM1 SOD1 PGF PAPPA

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.78 VEGFA PGF FLT1 ENG
2 positive regulation of protein kinase B signaling GO:0051897 9.71 VEGFA STOX1 ESR1 ENG
3 female pregnancy GO:0007565 9.67 PSG9 PSG11 PAPPA
4 response to hypoxia GO:0001666 9.67 VEGFA VCAM1 PGF ENG
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 VEGFA PGF FLT1
6 positive regulation of angiogenesis GO:0045766 9.62 VEGFA PGF FLT1 ENG
7 negative regulation of gene expression GO:0010629 9.55 XDH VEGFA STOX1 ESR1 ENG
8 mammary gland alveolus development GO:0060749 9.54 VEGFA ESR1
9 induction of positive chemotaxis GO:0050930 9.52 VEGFA PGF
10 positive regulation of phospholipase C activity GO:0010863 9.51 FLT1 ESR1
11 positive regulation of mast cell chemotaxis GO:0060754 9.43 VEGFA PGF
12 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 VEGFA VCAM1 FLT1
13 sprouting angiogenesis GO:0002040 9.13 VEGFA PGF ENG
14 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFA PGF FLT1

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFA PGF

Sources for Mild Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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