MCID: MLD002
MIFTS: 36

Mild Pre-Eclampsia

Categories: Cardiovascular diseases

Aliases & Classifications for Mild Pre-Eclampsia

MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 55 15 72
Mild Toxemia 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 35 642.40
UMLS 72 C0156664 C0269658 C0866321

Summaries for Mild Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to eclampsia and severe pre-eclampsia. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Oxidative Stress. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Mild Pre-Eclampsia

Diseases related to Mild Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 eclampsia 29.4 SERPINC1 PGF FLT1 ENG
2 severe pre-eclampsia 29.2 VCAM1 SERPINC1 PGF LEP
3 placental abruption 28.8 SERPINC1 PGF FLT1 ENG
4 hellp syndrome 28.8 SERPINC1 PGF FLT1 ENG
5 pre-eclampsia 27.1 VCAM1 SERPINC1 PGF LNPEP LEP IGFBP1
6 epithelioid hemangioendothelioma 10.3 PGF FLT1
7 persistent fetal circulation syndrome 10.3 PGF IGFBP1
8 cancer-associated retinopathy 10.3 PGF FLT1
9 placenta accreta 10.2 PGF FLT1
10 bronchopulmonary dysplasia 10.2 SOD1 FLT1
11 endocrine pancreas disease 10.1 LEP IGFBP1
12 glomeruloid hemangioma 10.1 FLT1 ENG
13 sickle cell disease 10.1 VCAM1 PGF
14 coronary artery aneurysm 10.1 VCAM1 LEP
15 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.0
16 47,xyy 10.0
17 platelet aggregation, spontaneous 10.0 SOD1 SERPINC1
18 microvascular complications of diabetes 5 10.0 VCAM1 PGF FLT1
19 subendocardial myocardial infarction 9.9 VCAM1 SERPINC1
20 myocardial stunning 9.9 SOD1 SERPINC1
21 retinal vascular occlusion 9.8 SERPINC1 PGF
22 pulmonary immaturity 9.8 VCAM1 SERPINC1
23 vascular cancer 9.8 FLT1 ENG
24 placental insufficiency 9.8 PGF LEP FLT1
25 twin-to-twin transfusion syndrome 9.7 PGF FLT1 ENG
26 retinal vascular disease 9.7 PGF FLT1
27 placenta disease 9.5 SERPINC1 PGF
28 arteries, anomalies of 8.8 VCAM1 SERPINC1 PGF LEP FLT1
29 vascular disease 8.5 XDH VCAM1 SOD1 SERPINC1 IGFBP1 ENG

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia

Symptoms & Phenotypes for Mild Pre-Eclampsia

MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ENG FLT1 LEP LNPEP PGF SERPINC1
2 growth/size/body region MP:0005378 9.97 ENG EVC2 FLT1 LEP LNPEP PGF
3 cellular MP:0005384 9.95 EVC2 FLT1 IGFBP1 LEP SOD1 VCAM1
4 homeostasis/metabolism MP:0005376 9.91 ENG FLT1 LEP LNPEP PGF SERPINC1
5 embryo MP:0005380 9.85 ENG FLT1 LEP PGF SERPINC1 VCAM1
6 immune system MP:0005387 9.76 FLT1 IGFBP1 LEP PGF SERPINC1 SOD1
7 mortality/aging MP:0010768 9.56 ENG EVC2 FLT1 LEP SERPINC1 SOD1
8 muscle MP:0005369 9.02 ENG FLT1 LEP SOD1 XDH

Drugs & Therapeutics for Mild Pre-Eclampsia

Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
3
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
4 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
5 Citrate Phase 2, Phase 3
6 Phosphodiesterase Inhibitors Phase 2, Phase 3
7 Chelating Agents Phase 2, Phase 3
8 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
9 Anticoagulants Phase 2, Phase 3
10 Vasodilator Agents Phase 2, Phase 3
11 Calcium, Dietary Phase 2, Phase 3
12 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial Unknown status NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
3 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
4 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
5 Effect of Remote Ischaemic Conditioning on Blood Pressure and Inflammatory Response in Women With Pre-clampsia and Gestational Hypertention Recruiting NCT03323762

Search NIH Clinical Center for Mild Pre-Eclampsia

Genetic Tests for Mild Pre-Eclampsia

Anatomical Context for Mild Pre-Eclampsia

MalaCards organs/tissues related to Mild Pre-Eclampsia:

41
Placenta, Liver, Endothelial, Neutrophil, Heart, Retina, Adipocyte

Publications for Mild Pre-Eclampsia

Articles related to Mild Pre-Eclampsia:

(show top 50) (show all 195)
# Title Authors PMID Year
1
Erythrocyte antioxidant enzymes and plasma antioxidant vitamins in Sudanese women with pre-eclampsia. 9 38
20143973 2010
2
[Expression of transforming growth factor-beta 1, vascular cell adhesion molecule-1 and endothelium-selectin in placenta of patients with pre-eclampsia]. 9 38
17083832 2006
3
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. 9 38
15248180 2004
4
Serum levels of insulin, IGF-1, and IGFBP-1 in pre-eclampsia and eclampsia. 9 38
15001368 2004
5
Vascular cell adhesion molecule-1 (VCAM-1) and leukocyte activation in pre-eclampsia and eclampsia. 9 38
9856316 1998
6
Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia. 38
29455633 2019
7
Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis. 38
30630878 2019
8
Sex Differences in Nutrition, Growth, and Metabolism in Preterm Infants. 38
30792973 2019
9
Correlation analysis of levels of inflammatory cytokines and nitric oxide in peripheral blood with urine proteins and renal function in patients with gestational hypertension. 38
30651847 2019
10
The clinical prognostic significance of myocardial performance index (MPI) in stable placental-mediated disease. 38
30152840 2018
11
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. 38
30158032 2018
12
Analgesic effect of adding magnesium sulfate to epidural levobupivacaine in patients with pre-eclampsia undergoing elective cesarean section. 38
30386015 2018
13
Hypertensive pregnancy complications in women with epilepsy and antiepileptic drugs: a population-based cohort study of first pregnancies in Norway. 38
29691249 2018
14
Study on the correlation between adipocyte fatty-acid binding protein, glucolipid metabolism, and pre-eclampsia. 38
29316087 2018
15
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. 38
29367581 2018
16
Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study. 38
29186464 2017
17
Clinical practice patterns on the use of magnesium sulphate for treatment of pre-eclampsia and eclampsia: a multi-country survey. 38
27885772 2017
18
A systematic review and meta-analysis of hypocalciuria in pre-eclampsia. 38
28369876 2017
19
Maternal circulating levels of transforming growth factor-β superfamily and its soluble receptors in hypertensive disorders of pregnancy. 38
28281288 2017
20
Is mean platelet volume a better biomarker in pre-eclampsia? 38
28422358 2017
21
[Effect of microRNA-106b on the invasion and proliferation of trophoblasts through targeting MMP-2]. 38
28545271 2017
22
Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes. 38
28501282 2017
23
Association of biochemical markers with the severity of pre-eclampsia. 38
28099727 2017
24
Impact of Road Traffic Pollution on Pre-eclampsia and Pregnancy-induced Hypertensive Disorders. 38
27648591 2017
25
Time from pre-eclampsia diagnosis to delivery affects future health prospects of children. 38
28421136 2017
26
Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term. 38
28106904 2017
27
Diagnosis of pre-eclampsia and assessment of severity through examination of the placenta with acoustic radiation force impulse elastography. 38
27452611 2016
28
Potential for task-sharing to Lady Health Workers for identification and emergency management of pre-eclampsia at community level in Pakistan. 38
27719680 2016
29
Prospective cohort study of persistent hypertension following pre-eclampsia at Medani Hospital, Sudan. 38
26975905 2016
30
Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia. 38
27039049 2016
31
Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. 38
26874361 2016
32
Nucleated Red Blood Cell Count in Maternal Peripheral Blood and Hypertensive Disorders in Pregnant Women. 38
26897268 2016
33
Association between polymorphisms in IL-27 gene and pre-eclampsia. 38
26654512 2016
34
Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? 38
26955767 2016
35
Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. 38
26177586 2015
36
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. 38
25833188 2015
37
Long-term maternal atherosclerotic morbidity in women with pre-eclampsia. 38
25564558 2015
38
Detection of early left ventricular dysfunction in patients with maternal placental syndrome using tissue Doppler and strain rate imaging. 38
25629901 2015
39
The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia. 38
25445606 2014
40
An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy. 38
25481580 2014
41
[Factors associated with mode of delivery in women with pre-eclampsia]. 38
25099465 2014
42
Concentrations of human chorionic gonadotrophin in very early pregnancy and subsequent pre-eclampsia: a cohort study. 38
24722241 2014
43
A simple method for the assessment of arterial stiffness in pre-eclamptic patients. 38
24786588 2014
44
[Is there a relationship between pregnancy induced hypertension and obstructive sleep apnea? Case report]. 38
24615199 2014
45
Maternal serum CA-125 level is elevated in severe preeclampsia. 38
26104251 2014
46
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. 38
24551706 2013
47
Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis. 38
24201165 2013
48
A Comparative Study of Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1), Intercellular Adhesion Molecule-1(ICAM-1) and High Sensitive C - reactive protein (hs-CRP) in Normal and Pre-eclamptic Pregnancies. 38
23826490 2013
49
Practice variation in late-preterm deliveries: a physician survey. 38
23018796 2013
50
Positive correlation between serum levels of adiponectin and homocysteine in pre-eclampsia. 38
23106812 2013

Variations for Mild Pre-Eclampsia

Expression for Mild Pre-Eclampsia

Search GEO for disease gene expression data for Mild Pre-Eclampsia.

Pathways for Mild Pre-Eclampsia

Pathways related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 XDH SOD1
2 10.65 XDH SOD1
3 10.61 LEP IGFBP1 ENG
4 10.37 SERPINC1 FLT1

GO Terms for Mild Pre-Eclampsia

Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 XDH SOD1 SERPINC1 PGF LNPEP LEP
2 extracellular space GO:0005615 9.28 XDH VCAM1 SOD1 SERPINC1 PGF LEP

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.63 VCAM1 SOD1 IGFBP1
2 response to hypoxia GO:0001666 9.61 VCAM1 PGF LEP
3 positive regulation of angiogenesis GO:0045766 9.58 PGF FLT1 ENG
4 lactation GO:0007595 9.56 XDH SERPINC1
5 placenta development GO:0001890 9.55 SOD1 LEP
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 VCAM1 FLT1
7 sprouting angiogenesis GO:0002040 9.52 PGF ENG
8 positive regulation of p38MAPK cascade GO:1900745 9.51 XDH LEP
9 positive regulation of reactive oxygen species metabolic process GO:2000379 9.49 XDH LEP
10 positive regulation of cytokine production GO:0001819 9.48 SOD1 LEP
11 response to ethanol GO:0045471 9.43 VCAM1 SOD1 LEP
12 leukocyte tethering or rolling GO:0050901 9.37 VCAM1 LEP
13 female pregnancy GO:0007565 9.33 PGF LNPEP LEP
14 vascular endothelial growth factor signaling pathway GO:0038084 9.32 PGF FLT1
15 response to nutrient GO:0007584 9.13 VCAM1 SERPINC1 LEP
16 angiogenesis GO:0001525 8.92 PGF LEP FLT1 ENG

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 IGFBP1 FLT1

Sources for Mild Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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