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MCID: MLD002
MIFTS: 35

Mild Pre-Eclampsia

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mild Pre-Eclampsia

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MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 55 15 73
Mild Toxemia 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 35 642.40
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Summaries for Mild Pre-Eclampsia

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Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to pre-eclampsia and eclampsia. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Doxorubicin Pathway, Pharmacokinetics. The drugs Citric Acid and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include retina, kidney and heart, and related phenotypes are cardiovascular system and growth/size/body region

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Related Diseases for Mild Pre-Eclampsia

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Diseases related to Mild Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 pre-eclampsia 29.9 VCAM1 PGF LNPEP LEP IGFBP1 FLT1
2 eclampsia 10.6
3 persistent fetal circulation syndrome 10.1 PGF IGFBP1
4 epithelioid hemangioendothelioma 10.1 PGF FLT1
5 cancer-associated retinopathy 10.1 PGF FLT1
6 twin-to-twin transfusion syndrome 10.1 PGF FLT1
7 placenta accreta 10.1 PGF FLT1
8 bronchopulmonary dysplasia 10.1 SOD1 FLT1
9 endocrine pancreas disease 10.0 LEP IGFBP1
10 placental abruption 10.0 PGF FLT1
11 sickle cell disease 10.0 VCAM1 PGF
12 coronary artery aneurysm 10.0 VCAM1 LEP
13 hellp syndrome 10.0
14 retinal vascular disease 10.0 PGF FLT1
15 microvascular complications of diabetes 5 9.9 VCAM1 PGF FLT1
16 nutritional deficiency disease 9.9 LEP IGFBP1
17 severe pre-eclampsia 9.9 VCAM1 PGF LEP
18 vascular disease 9.9 XDH VCAM1 SOD1 IGFBP1
19 placental insufficiency 9.9 PGF LEP FLT1
20 hypoplastic left heart syndrome 9.9 XDH LEP
21 chronic kidney failure 9.8 VCAM1 SOD1 LEP IGFBP1
22 arteries, anomalies of 9.8 VCAM1 PGF LEP FLT1

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia
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Symptoms & Phenotypes for Mild Pre-Eclampsia

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MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 FLT1 LEP LNPEP PGF SLC5A7 SOD1
2 growth/size/body region MP:0005378 9.8 FLT1 LEP LNPEP PGF SOD1 VCAM1
3 homeostasis/metabolism MP:0005376 9.76 FLT1 LEP LNPEP PGF SLC5A7 SOD1
4 immune system MP:0005387 9.56 FLT1 IGFBP1 LEP PGF SLC5A7 SOD1
5 vision/eye MP:0005391 9.02 FLT1 LEP PGF SLC5A7 SOD1
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Drugs & Therapeutics for Mild Pre-Eclampsia

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Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
2 Calcium, Dietary Phase 2, Phase 3,Not Applicable
3 Anticoagulants Phase 2, Phase 3
4 Phosphodiesterase Inhibitors Phase 2, Phase 3
5 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
6 Citrate Phase 2, Phase 3
7 Chelating Agents Phase 2, Phase 3
8 Vasodilator Agents Phase 2, Phase 3
9 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
10
Methyldopa Approved Phase 2 555-30-6 38853
11
Pseudoephedrine Approved Phase 2 90-82-4 7028
12
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
13
Ephedrine Approved Phase 2 299-42-3 9294
14
Morphine Approved, Investigational Phase 2 57-27-2 5288826
15
Atropine Approved, Vet_approved Phase 2 51-55-8, 5908-99-6 174174
16 Antihypertensive Agents Phase 2
17 Adrenergic alpha-Agonists Phase 2
18 Adrenergic Agents Phase 2
19 Adrenergic alpha-2 Receptor Agonists Phase 2
20 Autonomic Agents Phase 2
21 Adrenergic Agonists Phase 2
22 Peripheral Nervous System Agents Phase 2,Not Applicable
23 Neurotransmitter Agents Phase 2
24 Sympatholytics Phase 2
25 Analgesics, Opioid Phase 2
26 Plasma Substitutes Phase 2
27 Anti-Arrhythmia Agents Phase 2,Not Applicable
28 Anti-Asthmatic Agents Phase 2
29 Cholinergic Antagonists Phase 2
30 Narcotics Phase 2
31 Central Nervous System Stimulants Phase 2
32 Pharmaceutical Solutions Phase 2
33 Adjuvants, Anesthesia Phase 2
34 Parasympatholytics Phase 2
35 Nasal Decongestants Phase 2
36 Analgesics Phase 2,Not Applicable
37 Anesthetics, Local Phase 2
38 Anesthetics Phase 2,Not Applicable
39 Antifibrinolytic Agents Phase 2
40 Coagulants Phase 2
41 Central Nervous System Depressants Phase 2,Not Applicable
42 Mydriatics Phase 2
43 Sympathomimetics Phase 2
44 Blood Substitutes Phase 2
45 Cholinergic Agents Phase 2
46 Fibrin fragment D Phase 2
47 Hydroxyethyl Starch Derivatives Phase 2
48 Hemostatics Phase 2
49 Respiratory System Agents Phase 2
50 Vasoconstrictor Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Completed NCT01674127 Phase 2 Methyldopa;Placebo
3 Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia Completed NCT02622126 Phase 2 hydroxyethyl starch (6% 130/0.4);Hyperbaric bupivacaine;Morphine;Isotonic 0.9 sodium chloride (NaCl) solution;Ephedrine;Atropine
4 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
5 Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria Unknown status NCT01623791
6 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
7 Mild Preeclampsia Near Term: Deliver or Deliberate? Completed NCT00789919 Not Applicable
8 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
9 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
10 Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia Completed NCT00344058 Not Applicable abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
11 Maternal Periodontal Status and Cytokines in Preeclampsia Completed NCT03088228
12 Blood Pressure in Adolescents With PReclampsia and Eclampsia. Completed NCT03360240
13 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988
14 Preeclampsia Risk Assessment: Evaluation of Cut-offs to Improve Stratification Active, not recruiting NCT03815110
15 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03615560
16 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555

Search NIH Clinical Center for Mild Pre-Eclampsia

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Genetic Tests for Mild Pre-Eclampsia

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Anatomical Context for Mild Pre-Eclampsia

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MalaCards organs/tissues related to Mild Pre-Eclampsia:

41
Retina, Kidney, Heart, Pancreas, Placenta
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Publications for Mild Pre-Eclampsia

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Articles related to Mild Pre-Eclampsia:

(show all 16)
# Title Authors Year
1
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. ( 30158032 )
2018
2
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. ( 25833188 )
2015
3
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. ( 24551706 )
2013
4
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial. ( 22703475 )
2012
5
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia between 34 and 37 weeks' gestation (HYPITAT-II): a multicentre, open-label randomised controlled trial. ( 21736705 )
2011
6
Prediction of progression to a high risk situation in women with gestational hypertension or mild pre-eclampsia at term. ( 21806572 )
2011
7
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia. ( 20176870 )
2010
8
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. ( 19656558 )
2009
9
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. ( 15248180 )
2004
10
Methyldopa versus no drug treatment in the management of mild pre-eclampsia. ( 12625668 )
2002
11
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. ( 10492869 )
1999
12
The effect of magnesium sulphate on blood flow velocity in the maternal retina in mild pre-eclampsia: a preliminary colour flow Doppler study. ( 1390468 )
1992
13
Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome. ( 1471910 )
1992
14
Serum proteins in normal pregnancy and mild pre-eclampsia. ( 4104344 )
1971
15
Treatment of mild toxemia. ( 5955333 )
1966
16
Evaluation of a diuretic substance in the management of mild pre-eclampsia; a report of 47 clinical trials. ( 13595009 )
1958
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Variations for Mild Pre-Eclampsia

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Expression for Mild Pre-Eclampsia

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Search GEO for disease gene expression data for Mild Pre-Eclampsia.
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Pathways for Mild Pre-Eclampsia

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Pathways related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
HIF-1-alpha transcription factor network 1
11.07 IGFBP1 LEP
2
Doxorubicin Pathway, Pharmacokinetics 61
Show member pathways
 10.76 SOD1 XDH
3
Oxidative Stress 1
10.45 SOD1 XDH
4
VEGF binds to VEGFR leading to receptor dimerization 66
Show member pathways
 9.83 FLT1 PGF
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GO Terms for Mild Pre-Eclampsia

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Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 FLT1 IGFBP1 LEP LNPEP PGF SOD1
2 extracellular space GO:0005615 9.17 FLT1 IGFBP1 LEP PGF SOD1 VCAM1

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.67 FLT1 LEP PGF
2 regulation of blood pressure GO:0008217 9.56 LEP SOD1
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.55 FLT1 PGF
4 positive regulation of T cell proliferation GO:0042102 9.54 LEP VCAM1
5 aging GO:0007568 9.54 IGFBP1 SOD1 VCAM1
6 response to nutrient levels GO:0031667 9.52 LEP SOD1
7 placenta development GO:0001890 9.51 LEP SOD1
8 response to hypoxia GO:0001666 9.5 LEP PGF VCAM1
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.48 FLT1 VCAM1
10 positive regulation of p38MAPK cascade GO:1900745 9.46 LEP XDH
11 positive regulation of reactive oxygen species metabolic process GO:2000379 9.43 LEP XDH
12 positive regulation of cytokine production GO:0001819 9.4 LEP SOD1
13 leukocyte tethering or rolling GO:0050901 9.26 LEP VCAM1
14 vascular endothelial growth factor signaling pathway GO:0038084 9.16 FLT1 PGF
15 response to ethanol GO:0045471 9.13 LEP SOD1 VCAM1
16 female pregnancy GO:0007565 8.8 LEP LNPEP PGF

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 FLT1 IGFBP1
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Sources for Mild Pre-Eclampsia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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