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MCID: MLD002
MIFTS: 36

Mild Pre-Eclampsia

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mild Pre-Eclampsia

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MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 56 15 74
Mild Toxemia 74

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 36 642.40
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Summaries for Mild Pre-Eclampsia

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Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to eclampsia and hellp syndrome. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Oxidative Stress. The drugs Sodium Citrate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include liver and retina, and related phenotypes are cardiovascular system and growth/size/body region

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Related Diseases for Mild Pre-Eclampsia

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Diseases related to Mild Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.7 FLT1 PGF SERPINC1
2 hellp syndrome 29.8 FLT1 PGF SERPINC1
3 pre-eclampsia 29.0 FLT1 IGFBP1 LEP LNPEP PGF SERPINC1
4 epithelioid hemangioendothelioma 10.2 FLT1 PGF
5 persistent fetal circulation syndrome 10.2 IGFBP1 PGF
6 platelet aggregation, spontaneous 10.2 SERPINC1 SOD1
7 twin-to-twin transfusion syndrome 10.2 FLT1 PGF
8 cancer-associated retinopathy 10.2 FLT1 PGF
9 placenta accreta 10.1 FLT1 PGF
10 subendocardial myocardial infarction 10.1 SERPINC1 VCAM1
11 myocardial stunning 10.1 SERPINC1 SOD1
12 bronchopulmonary dysplasia 10.1 FLT1 SOD1
13 retinal vascular occlusion 10.1 PGF SERPINC1
14 pulmonary immaturity 10.0 SERPINC1 VCAM1
15 sickle cell disease 10.0 PGF VCAM1
16 microvascular complications of diabetes 5 10.0 FLT1 PGF VCAM1
17 retinal vascular disease 9.9 FLT1 PGF
18 placental abruption 9.9 FLT1 PGF SERPINC1
19 endocrine pancreas disease 9.9 IGFBP1 LEP
20 coronary artery aneurysm 9.8 LEP VCAM1
21 placenta disease 9.8 PGF SERPINC1
22 placental insufficiency 9.7 FLT1 LEP PGF
23 vascular disease 9.6 IGFBP1 SERPINC1 SOD1 VCAM1 XDH
24 chronic kidney failure 9.6 IGFBP1 LEP SOD1 VCAM1
25 severe pre-eclampsia 9.5 LEP PGF SERPINC1 VCAM1
26 arteries, anomalies of 9.2 FLT1 LEP PGF SERPINC1 VCAM1

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia
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Symptoms & Phenotypes for Mild Pre-Eclampsia

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MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 FLT1 LEP LNPEP PGF SERPINC1 SLC5A7
2 growth/size/body region MP:0005378 9.97 EVC2 FLT1 LEP LNPEP PGF SOD1
3 homeostasis/metabolism MP:0005376 9.97 FLT1 LEP LNPEP PGF SERPINC1 SLC5A7
4 cellular MP:0005384 9.95 EVC2 FLT1 IGFBP1 LEP SOD1 VCAM1
5 immune system MP:0005387 9.91 FLT1 IGFBP1 LEP PGF SERPINC1 SLC5A7
6 mortality/aging MP:0010768 9.56 EVC2 FLT1 LEP SERPINC1 SLC5A7 SOD1
7 liver/biliary system MP:0005370 9.55 IGFBP1 LEP SERPINC1 SLC5A7 SOD1
8 vision/eye MP:0005391 9.1 FLT1 LEP PGF SERPINC1 SLC5A7 SOD1
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Drugs & Therapeutics for Mild Pre-Eclampsia

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Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 2, Phase 3 68-04-2
2
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
4 Calcium, Dietary Phase 2, Phase 3,Not Applicable
5 Vasodilator Agents Phase 2, Phase 3
6 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
7 Chelating Agents Phase 2, Phase 3
8 Citrate Phase 2, Phase 3
9 Anticoagulants Phase 2, Phase 3
10 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
11 Phosphodiesterase Inhibitors Phase 2, Phase 3
12
Methyldopa Approved Phase 2 555-30-6 38853
13
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
14
Ephedrine Approved Phase 2 299-42-3 9294
15
Morphine Approved, Investigational Phase 2 57-27-2 5288826
16
Atropine Approved, Vet_approved Phase 2 51-55-8, 5908-99-6 174174
17
Pseudoephedrine Approved Phase 2 90-82-4 7028
18 Antihypertensive Agents Phase 2
19 Adrenergic Agents Phase 2
20 Adrenergic alpha-Agonists Phase 2
21 Neurotransmitter Agents Phase 2
22 Adrenergic alpha-2 Receptor Agonists Phase 2
23 Sympatholytics Phase 2
24 Adrenergic Agonists Phase 2
25 Autonomic Agents Phase 2
26 Peripheral Nervous System Agents Phase 2,Not Applicable
27 Central Nervous System Depressants Phase 2,Not Applicable
28 Analgesics, Opioid Phase 2
29 Coagulants Phase 2
30 Antifibrinolytic Agents Phase 2
31 Mydriatics Phase 2
32 Parasympatholytics Phase 2
33 Nasal Decongestants Phase 2
34 Anti-Asthmatic Agents Phase 2
35 Anti-Arrhythmia Agents Phase 2,Not Applicable
36 Cholinergic Agents Phase 2
37 Cholinergic Antagonists Phase 2
38 Hydroxyethyl Starch Derivatives Phase 2
39 Vasoconstrictor Agents Phase 2
40 Anesthetics, Local Phase 2
41 Narcotics Phase 2
42 Plasma Substitutes Phase 2
43 Anesthetics Phase 2,Not Applicable
44 Sympathomimetics Phase 2
45 Analgesics Phase 2,Not Applicable
46 Muscarinic Antagonists Phase 2
47 Respiratory System Agents Phase 2
48 Adjuvants, Anesthesia Phase 2
49 Bronchodilator Agents Phase 2
50 Fibrin fragment D Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Completed NCT01674127 Phase 2 Methyldopa;Placebo
3 Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia Completed NCT02622126 Phase 2 hydroxyethyl starch (6% 130/0.4);Hyperbaric bupivacaine;Morphine;Isotonic 0.9 sodium chloride (NaCl) solution;Ephedrine;Atropine
4 Ä°s There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
5 Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria Unknown status NCT01623791
6 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
7 Mild Preeclampsia Near Term: Deliver or Deliberate? Completed NCT00789919 Not Applicable
8 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
9 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
10 Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia Completed NCT00344058 Not Applicable abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
11 Maternal Periodontal Status and Cytokines in Preeclampsia Completed NCT03088228
12 Blood Pressure in Adolescents With PReclampsia and Eclampsia. Completed NCT03360240
13 Preeclampsia Risk Assessment: Evaluation of Cut-offs to Improve Stratification Recruiting NCT03815110
14 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988
15 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03615560
16 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555

Search NIH Clinical Center for Mild Pre-Eclampsia

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Genetic Tests for Mild Pre-Eclampsia

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Anatomical Context for Mild Pre-Eclampsia

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MalaCards organs/tissues related to Mild Pre-Eclampsia:

42
Liver, Retina
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Publications for Mild Pre-Eclampsia

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Articles related to Mild Pre-Eclampsia:

(show all 17)
# Title Authors Year
1
Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis. ( 30630878 )
2019
2
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. ( 30158032 )
2018
3
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. ( 25833188 )
2015
4
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. ( 24551706 )
2013
5
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial. ( 22703475 )
2012
6
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia between 34 and 37 weeks' gestation (HYPITAT-II): a multicentre, open-label randomised controlled trial. ( 21736705 )
2011
7
Prediction of progression to a high risk situation in women with gestational hypertension or mild pre-eclampsia at term. ( 21806572 )
2011
8
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia. ( 20176870 )
2010
9
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. ( 19656558 )
2009
10
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. ( 15248180 )
2004
11
Methyldopa versus no drug treatment in the management of mild pre-eclampsia. ( 12625668 )
2002
12
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. ( 10492869 )
1999
13
The effect of magnesium sulphate on blood flow velocity in the maternal retina in mild pre-eclampsia: a preliminary colour flow Doppler study. ( 1390468 )
1992
14
Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome. ( 1471910 )
1992
15
Serum proteins in normal pregnancy and mild pre-eclampsia. ( 4104344 )
1971
16
Treatment of mild toxemia. ( 5955333 )
1966
17
Evaluation of a diuretic substance in the management of mild pre-eclampsia; a report of 47 clinical trials. ( 13595009 )
1958
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Variations for Mild Pre-Eclampsia

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Expression for Mild Pre-Eclampsia

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Search GEO for disease gene expression data for Mild Pre-Eclampsia.
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Pathways for Mild Pre-Eclampsia

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Pathways related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Doxorubicin Pathway, Pharmacokinetics 62
Show member pathways
 10.76 SOD1 XDH
2
Oxidative Stress 1
10.45 SOD1 XDH
3
Glypican 1 network 1
10.04 FLT1 SERPINC1
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GO Terms for Mild Pre-Eclampsia

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Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 FLT1 IGFBP1 LEP LNPEP PGF SERPINC1
2 extracellular space GO:0005615 9.23 FLT1 IGFBP1 LEP PGF SERPINC1 SOD1

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.69 FLT1 LEP PGF
2 aging GO:0007568 9.58 IGFBP1 SOD1 VCAM1
3 lactation GO:0007595 9.54 SERPINC1 XDH
4 response to hypoxia GO:0001666 9.54 LEP PGF VCAM1
5 placenta development GO:0001890 9.52 LEP SOD1
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.49 FLT1 VCAM1
7 positive regulation of p38MAPK cascade GO:1900745 9.48 LEP XDH
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.46 LEP XDH
9 positive regulation of cytokine production GO:0001819 9.43 LEP SOD1
10 response to ethanol GO:0045471 9.33 LEP SOD1 VCAM1
11 leukocyte tethering or rolling GO:0050901 9.32 LEP VCAM1
12 vascular endothelial growth factor signaling pathway GO:0038084 9.26 FLT1 PGF
13 female pregnancy GO:0007565 9.13 LEP LNPEP PGF
14 response to nutrient GO:0007584 8.8 LEP SERPINC1 VCAM1

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 FLT1 IGFBP1
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Sources for Mild Pre-Eclampsia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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