MCID: MLD002
MIFTS: 37

Mild Pre-Eclampsia

Categories: Cardiovascular diseases

Aliases & Classifications for Mild Pre-Eclampsia

MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 56 15 74
Mild Toxemia 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 36 642.40

Summaries for Mild Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to eclampsia and hellp syndrome. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Oxidative Stress. The drugs Sodium Citrate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and retina, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Mild Pre-Eclampsia

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia

Symptoms & Phenotypes for Mild Pre-Eclampsia

MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 FLT1 LEP LNPEP PGF SERPINC1 SLC5A7
2 growth/size/body region MP:0005378 9.97 EVC2 FLT1 LEP LNPEP PGF SOD1
3 homeostasis/metabolism MP:0005376 9.97 FLT1 LEP LNPEP PGF SERPINC1 SLC5A7
4 cellular MP:0005384 9.95 EVC2 FLT1 IGFBP1 LEP SOD1 VCAM1
5 immune system MP:0005387 9.91 FLT1 IGFBP1 LEP PGF SERPINC1 SLC5A7
6 mortality/aging MP:0010768 9.56 EVC2 FLT1 LEP SERPINC1 SLC5A7 SOD1
7 liver/biliary system MP:0005370 9.55 IGFBP1 LEP SERPINC1 SLC5A7 SOD1
8 vision/eye MP:0005391 9.1 FLT1 LEP PGF SERPINC1 SLC5A7 SOD1

Drugs & Therapeutics for Mild Pre-Eclampsia

Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 2, Phase 3 68-04-2
2
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
4 Calcium, Dietary Phase 2, Phase 3,Not Applicable
5 Phosphodiesterase Inhibitors Phase 2, Phase 3
6 Anticoagulants Phase 2, Phase 3
7 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
8 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
9 Vasodilator Agents Phase 2, Phase 3
10 Citrate Phase 2, Phase 3
11 Chelating Agents Phase 2, Phase 3
12
Methyldopa Approved Phase 2 555-30-6 38853
13
Atropine Approved, Vet_approved Phase 2 5908-99-6, 51-55-8 174174
14
Pseudoephedrine Approved Phase 2 90-82-4 7028
15
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
16
Morphine Approved, Investigational Phase 2 57-27-2 5288826
17
Ephedrine Approved Phase 2 299-42-3 9294
18 Autonomic Agents Phase 2
19 Adrenergic Agonists Phase 2
20 Adrenergic Agents Phase 2
21 Adrenergic alpha-Agonists Phase 2
22 Peripheral Nervous System Agents Phase 2,Not Applicable
23 Sympatholytics Phase 2
24 Antihypertensive Agents Phase 2
25 Neurotransmitter Agents Phase 2
26 Adrenergic alpha-2 Receptor Agonists Phase 2
27 Analgesics, Opioid Phase 2
28 Pharmaceutical Solutions Phase 2
29 Hydroxyethyl Starch Derivatives Phase 2
30 Fibrin fragment D Phase 2
31 Anesthetics Phase 2,Not Applicable
32 Parasympatholytics Phase 2
33 Analgesics Phase 2,Not Applicable
34 Muscarinic Antagonists Phase 2
35 Bronchodilator Agents Phase 2
36 Central Nervous System Depressants Phase 2,Not Applicable
37 Hemostatics Phase 2
38 Adjuvants, Anesthesia Phase 2
39 Nasal Decongestants Phase 2
40 Coagulants Phase 2
41 Anti-Arrhythmia Agents Phase 2,Not Applicable
42 Sympathomimetics Phase 2
43 Central Nervous System Stimulants Phase 2
44 Vasoconstrictor Agents Phase 2
45 Cholinergic Antagonists Phase 2
46 Blood Substitutes Phase 2
47 Anesthetics, Local Phase 2
48 Respiratory System Agents Phase 2
49 Plasma Substitutes Phase 2
50 Mydriatics Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Completed NCT01674127 Phase 2 Methyldopa;Placebo
3 Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia Completed NCT02622126 Phase 2 hydroxyethyl starch (6% 130/0.4);Hyperbaric bupivacaine;Morphine;Isotonic 0.9 sodium chloride (NaCl) solution;Ephedrine;Atropine
4 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
5 Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria Unknown status NCT01623791
6 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
7 Mild Preeclampsia Near Term: Deliver or Deliberate? Completed NCT00789919 Not Applicable
8 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
9 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
10 Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia Completed NCT00344058 Not Applicable abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
11 Maternal Periodontal Status and Cytokines in Preeclampsia Completed NCT03088228
12 Blood Pressure in Adolescents With PReclampsia and Eclampsia. Completed NCT03360240
13 Preeclampsia Risk Assessment: Evaluation of Cut-offs to Improve Stratification Recruiting NCT03815110
14 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988
15 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03615560
16 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555

Search NIH Clinical Center for Mild Pre-Eclampsia

Genetic Tests for Mild Pre-Eclampsia

Anatomical Context for Mild Pre-Eclampsia

MalaCards organs/tissues related to Mild Pre-Eclampsia:

42
Liver, Placenta, Retina, Kidney, Pancreas

Publications for Mild Pre-Eclampsia

Articles related to Mild Pre-Eclampsia:

(show all 17)
# Title Authors Year
1
Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis. ( 30630878 )
2019
2
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. ( 30158032 )
2018
3
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. ( 25833188 )
2015
4
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. ( 24551706 )
2013
5
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial. ( 22703475 )
2012
6
Prediction of progression to a high risk situation in women with gestational hypertension or mild pre-eclampsia at term. ( 21806572 )
2011
7
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia between 34 and 37 weeks' gestation (HYPITAT-II): a multicentre, open-label randomised controlled trial. ( 21736705 )
2011
8
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia. ( 20176870 )
2010
9
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. ( 19656558 )
2009
10
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. ( 15248180 )
2004
11
Methyldopa versus no drug treatment in the management of mild pre-eclampsia. ( 12625668 )
2002
12
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. ( 10492869 )
1999
13
Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome. ( 1471910 )
1992
14
The effect of magnesium sulphate on blood flow velocity in the maternal retina in mild pre-eclampsia: a preliminary colour flow Doppler study. ( 1390468 )
1992
15
Serum proteins in normal pregnancy and mild pre-eclampsia. ( 4104344 )
1971
16
Treatment of mild toxemia. ( 5955333 )
1966
17
Evaluation of a diuretic substance in the management of mild pre-eclampsia; a report of 47 clinical trials. ( 13595009 )
1958

Variations for Mild Pre-Eclampsia

Expression for Mild Pre-Eclampsia

Search GEO for disease gene expression data for Mild Pre-Eclampsia.

Pathways for Mild Pre-Eclampsia

Pathways related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 SOD1 XDH
2 10.45 SOD1 XDH
3 10.04 FLT1 SERPINC1

GO Terms for Mild Pre-Eclampsia

Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 FLT1 IGFBP1 LEP LNPEP PGF SERPINC1
2 extracellular space GO:0005615 9.23 FLT1 IGFBP1 LEP PGF SERPINC1 SOD1

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.69 FLT1 LEP PGF
2 aging GO:0007568 9.58 IGFBP1 SOD1 VCAM1
3 lactation GO:0007595 9.54 SERPINC1 XDH
4 response to hypoxia GO:0001666 9.54 LEP PGF VCAM1
5 placenta development GO:0001890 9.52 LEP SOD1
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.49 FLT1 VCAM1
7 positive regulation of p38MAPK cascade GO:1900745 9.48 LEP XDH
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.46 LEP XDH
9 positive regulation of cytokine production GO:0001819 9.43 LEP SOD1
10 response to ethanol GO:0045471 9.33 LEP SOD1 VCAM1
11 leukocyte tethering or rolling GO:0050901 9.32 LEP VCAM1
12 vascular endothelial growth factor signaling pathway GO:0038084 9.26 FLT1 PGF
13 female pregnancy GO:0007565 9.13 LEP LNPEP PGF
14 response to nutrient GO:0007584 8.8 LEP SERPINC1 VCAM1

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 FLT1 IGFBP1

Sources for Mild Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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