MCID: MLD002
MIFTS: 36

Mild Pre-Eclampsia

Categories: Cardiovascular diseases

Aliases & Classifications for Mild Pre-Eclampsia

MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 54 15 71
Mild Toxemia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 34 642.40
UMLS 71 C0156664 C0269658 C0866321

Summaries for Mild Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to placental abruption and eclampsia. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Signaling events mediated by VEGFR1 and VEGFR2. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Mild Pre-Eclampsia

Diseases related to Mild Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 placental abruption 30.1 PGF PAPPA FLT1 ENG
2 eclampsia 29.0 VEGFA PGF PAPPA OXT LGALS13 FLT1
3 hellp syndrome 28.8 VEGFA PGF LGALS13 LEP FLT1 ENG
4 severe pre-eclampsia 28.7 VEGFA VCAM1 PGF PAPPA MIR517A LGALS13
5 pre-eclampsia 26.5 XDH VEGFA VCAM1 SOD1 PGF PAPPA
6 pyridoxine deficiency anemia 10.4 VCAM1 IGFBP1
7 vaginal adenoma 10.1 PGF OXT
8 microcystic meningioma 10.1 VEGFA FLT1
9 vaginal benign neoplasm 10.0 PGF OXT
10 insulin-like growth factor i 10.0 LEP IGFBP1 ESR1
11 eales disease 10.0 VEGFA SOD1
12 lipodermatosclerosis 10.0 VEGFA FLT1
13 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.0
14 47,xyy 10.0
15 hypertensive encephalopathy 10.0 VEGFA FLT1
16 angiokeratoma circumscriptum 10.0 VEGFA FLT1
17 primary cutaneous b-cell lymphoma 9.9 VEGFA FLT1
18 juvenile nasopharyngeal angiofibroma 9.9 VEGFA ESR1 ENG
19 late congenital syphilis 9.9 OXT ENG
20 dupuytren contracture 9.9 XDH VEGFA
21 severe nonproliferative diabetic retinopathy 9.9 VEGFA PGF
22 placenta praevia 9.9 PGF PAPPA OXT
23 cancer-associated retinopathy 9.9 VEGFA PGF FLT1
24 osteonecrosis 9.9 VEGFA ESR1 ENG
25 breast carcinoma in situ 9.9 VEGFA FLT1 ESR1
26 epithelioid hemangioendothelioma 9.9 VEGFA PGF FLT1
27 kuhnt-junius degeneration 9.9 VEGFA PGF FLT1
28 neovascular glaucoma 9.9 VEGFA PGF FLT1
29 blood group, globoside system 9.9 VEGFA PGF FLT1
30 microvascular complications of diabetes 1 9.9 VEGFA VCAM1 FLT1
31 macular retinal edema 9.9 VEGFA PGF FLT1
32 retinal vascular occlusion 9.9 VEGFA PGF FLT1
33 turner syndrome 9.9 PAPPA LEP IGFBP1
34 intussusception 9.9 VEGFA PGF FLT1
35 endophthalmitis 9.9 VEGFA PGF FLT1
36 glomeruloid hemangioma 9.9 VEGFA FLT1 ENG
37 peripheral artery disease 9.9 VEGFA VCAM1 ENG
38 retinal artery occlusion 9.9 VEGFA PGF FLT1
39 diabetic macular edema 9.9 VEGFA PGF FLT1
40 neonatal anemia 9.8 PGF PAPPA FLT1 ENG
41 twin-to-twin transfusion syndrome 9.8 PGF PAPPA FLT1 ENG
42 vascular cancer 9.8 VEGFA FLT1 ENG
43 arteriovenous malformations of the brain 9.8 VEGFA FLT1 ENG
44 myoma 9.8 OXT LEP ESR1
45 adenomyosis 9.8 VEGFA OXT ESR1
46 sick building syndrome 9.7 VEGFA LEP
47 ischemia 9.7 XDH VEGFA SOD1 MIR195
48 gestational diabetes 9.7 PGF PAPPA LEP IGFBP1
49 oligohydramnios 9.7 PGF PAPPA OXT MIR517A
50 primary peritoneal carcinoma 9.7 VEGFA MIR195

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia

Symptoms & Phenotypes for Mild Pre-Eclampsia

MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ENG ESR1 FLT1 LEP LNPEP OXT
2 growth/size/body region MP:0005378 10.03 ENG ESR1 FLT1 LEP LNPEP OXT
3 homeostasis/metabolism MP:0005376 9.93 ENG ESR1 FLT1 LEP LNPEP OXT
4 integument MP:0010771 9.56 ENG ESR1 LEP OXT PGF SOD1
5 muscle MP:0005369 9.17 ENG ESR1 FLT1 LEP SOD1 VEGFA

Drugs & Therapeutics for Mild Pre-Eclampsia

Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
3 Phosphodiesterase Inhibitors Phase 2, Phase 3
4 Citrate Phase 2, Phase 3
5 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
6 Vasodilator Agents Phase 2, Phase 3
7 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
8 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial Unknown status NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
3 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
4 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
5 Effect of Remote Ischaemic Conditioning on Blood Pressure and Inflammatory Response in Women With Pre-clampsia and Gestational Hypertention Recruiting NCT03323762

Search NIH Clinical Center for Mild Pre-Eclampsia

Genetic Tests for Mild Pre-Eclampsia

Anatomical Context for Mild Pre-Eclampsia

MalaCards organs/tissues related to Mild Pre-Eclampsia:

40
Placenta, Liver, Endothelial, Neutrophil, Retina, Heart, Adipocyte

Publications for Mild Pre-Eclampsia

Articles related to Mild Pre-Eclampsia:

(show top 50) (show all 198)
# Title Authors PMID Year
1
Erythrocyte antioxidant enzymes and plasma antioxidant vitamins in Sudanese women with pre-eclampsia. 54 61
20143973 2010
2
[Expression of transforming growth factor-beta 1, vascular cell adhesion molecule-1 and endothelium-selectin in placenta of patients with pre-eclampsia]. 61 54
17083832 2006
3
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. 54 61
15248180 2004
4
Serum levels of insulin, IGF-1, and IGFBP-1 in pre-eclampsia and eclampsia. 61 54
15001368 2004
5
Vascular cell adhesion molecule-1 (VCAM-1) and leukocyte activation in pre-eclampsia and eclampsia. 61 54
9856316 1998
6
CD25+ FOXP3+ and CD4+ CD25+ cells distribution in decidual departments of women with severe and mild pre-eclampsia: Comparison with healthy pregnancies. 61
32485016 2020
7
Impact of Hypertension and Preeclampsia Intervention Trial At Near Term-I (HYPITAT-I) on obstetric management and outcome in The Netherlands. 61
31486156 2020
8
Peripartum management of hypertension. A position paper of the ESC Council on Hypertension and the European Society of Hypertension. 61
31841131 2019
9
Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia. 61
29455633 2019
10
Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis. 61
30630878 2019
11
Sex Differences in Nutrition, Growth, and Metabolism in Preterm Infants. 61
30792973 2019
12
Correlation analysis of levels of inflammatory cytokines and nitric oxide in peripheral blood with urine proteins and renal function in patients with gestational hypertension. 61
30651847 2019
13
The clinical prognostic significance of myocardial performance index (MPI) in stable placental-mediated disease. 61
30152840 2018
14
Elective Induction versus Expectant Management of Mild Pre-Eclampsia at Term. 61
30158032 2018
15
Analgesic effect of adding magnesium sulfate to epidural levobupivacaine in patients with pre-eclampsia undergoing elective cesarean section. 61
30386015 2018
16
Hypertensive pregnancy complications in women with epilepsy and antiepileptic drugs: a population-based cohort study of first pregnancies in Norway. 61
29691249 2018
17
Study on the correlation between adipocyte fatty-acid binding protein, glucolipid metabolism, and pre-eclampsia. 61
29316087 2018
18
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. 61
29367581 2018
19
Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study. 61
29186464 2017
20
Clinical practice patterns on the use of magnesium sulphate for treatment of pre-eclampsia and eclampsia: a multi-country survey. 61
27885772 2017
21
A systematic review and meta-analysis of hypocalciuria in pre-eclampsia. 61
28369876 2017
22
Maternal circulating levels of transforming growth factor-β superfamily and its soluble receptors in hypertensive disorders of pregnancy. 61
28281288 2017
23
Is mean platelet volume a better biomarker in pre-eclampsia? 61
28422358 2017
24
[Effect of microRNA-106b on the invasion and proliferation of trophoblasts through targeting MMP-2]. 61
28545271 2017
25
Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes. 61
28501282 2017
26
Association of biochemical markers with the severity of pre-eclampsia. 61
28099727 2017
27
Impact of Road Traffic Pollution on Pre-eclampsia and Pregnancy-induced Hypertensive Disorders. 61
27648591 2017
28
Time from pre-eclampsia diagnosis to delivery affects future health prospects of children. 61
28421136 2017
29
Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term. 61
28106904 2017
30
Diagnosis of pre-eclampsia and assessment of severity through examination of the placenta with acoustic radiation force impulse elastography. 61
27452611 2016
31
Potential for task-sharing to Lady Health Workers for identification and emergency management of pre-eclampsia at community level in Pakistan. 61
27719680 2016
32
Prospective cohort study of persistent hypertension following pre-eclampsia at Medani Hospital, Sudan. 61
26975905 2016
33
Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia. 61
27039049 2016
34
Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. 61
26874361 2016
35
Nucleated Red Blood Cell Count in Maternal Peripheral Blood and Hypertensive Disorders in Pregnant Women. 61
26897268 2016
36
Association between polymorphisms in IL-27 gene and pre-eclampsia. 61
26654512 2016
37
Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? 61
26955767 2016
38
Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. 61
26177586 2015
39
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. 61
25833188 2015
40
Long-term maternal atherosclerotic morbidity in women with pre-eclampsia. 61
25564558 2015
41
Detection of early left ventricular dysfunction in patients with maternal placental syndrome using tissue Doppler and strain rate imaging. 61
25629901 2015
42
The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia. 61
25445606 2014
43
An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy. 61
25481580 2014
44
[Factors associated with mode of delivery in women with pre-eclampsia]. 61
25099465 2014
45
Concentrations of human chorionic gonadotrophin in very early pregnancy and subsequent pre-eclampsia: a cohort study. 61
24722241 2014
46
A simple method for the assessment of arterial stiffness in pre-eclamptic patients. 61
24786588 2014
47
[Is there a relationship between pregnancy induced hypertension and obstructive sleep apnea? Case report]. 61
24615199 2014
48
Maternal serum CA-125 level is elevated in severe preeclampsia. 61
26104251 2014
49
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. 61
24551706 2013
50
Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis. 61
24201165 2013

Variations for Mild Pre-Eclampsia

Expression for Mild Pre-Eclampsia

Search GEO for disease gene expression data for Mild Pre-Eclampsia.

Pathways for Mild Pre-Eclampsia

GO Terms for Mild Pre-Eclampsia

Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 XDH VEGFA SOD1 PSG11 PGF PAPPA
2 extracellular space GO:0005615 9.44 XDH VEGFA VCAM1 SOD1 PGF PAPPA
3 secretory granule GO:0030141 9.33 VEGFA SOD1 OXT

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.84 XDH VEGFA ESR1 ENG
2 positive regulation of protein phosphorylation GO:0001934 9.73 VEGFA PGF LEP ENG
3 response to estradiol GO:0032355 9.72 OXT LEP ESR1
4 positive regulation of cold-induced thermogenesis GO:0120162 9.69 VEGFA OXT LEP
5 positive regulation of angiogenesis GO:0045766 9.67 VEGFA PGF FLT1 ENG
6 angiogenesis GO:0001525 9.65 VEGFA PGF LEP FLT1 ENG
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 VEGFA PGF FLT1
8 leukocyte tethering or rolling GO:0050901 9.58 VCAM1 LEP
9 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.57 VEGFA FLT1
10 mammary gland alveolus development GO:0060749 9.56 VEGFA ESR1
11 induction of positive chemotaxis GO:0050930 9.52 VEGFA PGF
12 positive regulation of p38MAPK cascade GO:1900745 9.5 XDH VEGFA LEP
13 positive regulation of phospholipase C activity GO:0010863 9.49 FLT1 ESR1
14 cardiac muscle hypertrophy GO:0003300 9.48 MIR195 LEP
15 positive regulation of mast cell chemotaxis GO:0060754 9.4 VEGFA PGF
16 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFA PGF FLT1
17 sprouting angiogenesis GO:0002040 9.26 VEGFA PGF FLT1 ENG
18 female pregnancy GO:0007565 9.1 PSG11 PGF PAPPA OXT LNPEP LEP

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFA PGF

Sources for Mild Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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