MCID: MLD002
MIFTS: 35

Mild Pre-Eclampsia

Categories: Cardiovascular diseases

Aliases & Classifications for Mild Pre-Eclampsia

MalaCards integrated aliases for Mild Pre-Eclampsia:

Name: Mild Pre-Eclampsia 12 55 15 73
Mild Toxemia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10590
ICD9CM 35 642.40

Summaries for Mild Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.

MalaCards based summary : Mild Pre-Eclampsia, also known as mild toxemia, is related to pre-eclampsia and anoxia. An important gene associated with Mild Pre-Eclampsia is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Oxidative Stress. The drugs Citric Acid and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include liver and retina, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Mild Pre-Eclampsia

Graphical network of the top 20 diseases related to Mild Pre-Eclampsia:



Diseases related to Mild Pre-Eclampsia

Symptoms & Phenotypes for Mild Pre-Eclampsia

MGI Mouse Phenotypes related to Mild Pre-Eclampsia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 LNPEP PGF SLC5A7 SOD1 VCAM1 FLT1
2 growth/size/body region MP:0005378 9.8 LEP LNPEP PGF SOD1 VCAM1 FLT1
3 homeostasis/metabolism MP:0005376 9.76 LNPEP PGF SLC5A7 SOD1 VCAM1 FLT1
4 immune system MP:0005387 9.56 PGF SLC5A7 SOD1 VCAM1 FLT1 XDH
5 vision/eye MP:0005391 9.02 LEP PGF SLC5A7 SOD1 FLT1

Drugs & Therapeutics for Mild Pre-Eclampsia

Drugs for Mild Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
2 Calcium, Dietary Phase 2, Phase 3,Not Applicable
3 Anticoagulants Phase 2, Phase 3
4 Chelating Agents Phase 2, Phase 3
5 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
6 Phosphodiesterase Inhibitors Phase 2, Phase 3
7 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
8 Vasodilator Agents Phase 2, Phase 3
9 Citrate Nutraceutical Phase 2, Phase 3
10
Methyldopa Approved Phase 2 555-30-6 38853
11
Atropine Approved, Vet_approved Phase 2 5908-99-6, 51-55-8 174174
12
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
13
Ephedrine Approved Phase 2 299-42-3 9294
14
Morphine Approved, Investigational Phase 2 57-27-2 5288826
15
Pseudoephedrine Approved Phase 2 90-82-4 7028
16 Adrenergic Agents Phase 2
17 Adrenergic Agonists Phase 2
18 Adrenergic alpha-2 Receptor Agonists Phase 2
19 Adrenergic alpha-Agonists Phase 2
20 Antihypertensive Agents Phase 2
21 Autonomic Agents Phase 2
22 Neurotransmitter Agents Phase 2
23 Peripheral Nervous System Agents Phase 2,Not Applicable
24 Sympatholytics Phase 2
25 Adjuvants, Anesthesia Phase 2
26 Analgesics Phase 2,Not Applicable
27 Analgesics, Opioid Phase 2
28 Anesthetics Phase 2,Not Applicable
29 Anesthetics, Local Phase 2
30 Anti-Arrhythmia Agents Phase 2,Not Applicable
31 Anti-Asthmatic Agents Phase 2
32 Antifibrinolytic Agents Phase 2
33 Blood Substitutes Phase 2
34 Bronchodilator Agents Phase 2
35 Central Nervous System Depressants Phase 2,Not Applicable
36 Central Nervous System Stimulants Phase 2
37 Cholinergic Agents Phase 2
38 Cholinergic Antagonists Phase 2
39 Coagulants Phase 2
40 Fibrin fragment D Phase 2
41 Hemostatics Phase 2
42 Hydroxyethyl Starch Derivatives Phase 2
43 Muscarinic Antagonists Phase 2
44 Mydriatics Phase 2
45 Narcotics Phase 2
46 Nasal Decongestants Phase 2
47 Parasympatholytics Phase 2
48 Pharmaceutical Solutions Phase 2
49 Plasma Substitutes Phase 2
50 Respiratory System Agents Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
2 Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Completed NCT01674127 Phase 2 Methyldopa;Placebo
3 Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia Completed NCT02622126 Phase 2 hydroxyethyl starch (6% 130/0.4);Hyperbaric bupivacaine;Morphine;Isotonic 0.9 sodium chloride (NaCl) solution;Ephedrine;Atropine
4 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
5 Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria Unknown status NCT01623791
6 CA-125 and Severity of Pre-Eclampsia Unknown status NCT02704676
7 Mild Preeclampsia Near Term: Deliver or Deliberate? Completed NCT00789919 Not Applicable
8 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
9 Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach Completed NCT02164370
10 Abbreviated MgSO4 Therapy in Post-Partum Preeclampsia Completed NCT00344058 Not Applicable abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
11 Maternal Periodontal Status and Cytokines in Preeclampsia Completed NCT03088228
12 Blood Pressure in Adolescents With PReclampsia and Eclampsia. Completed NCT03360240
13 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555

Search NIH Clinical Center for Mild Pre-Eclampsia

Genetic Tests for Mild Pre-Eclampsia

Anatomical Context for Mild Pre-Eclampsia

MalaCards organs/tissues related to Mild Pre-Eclampsia:

41
Liver, Retina

Publications for Mild Pre-Eclampsia

Articles related to Mild Pre-Eclampsia:

(show all 14)
# Title Authors Year
1
Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia. ( 25833188 )
2015
2
Late Postpartum HELLP Syndrome 60 Hours after Delivery Associated with Mild Pre-eclampsia. ( 24551706 )
2013
3
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial. ( 22703475 )
2012
4
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia between 34 and 37 weeks' gestation (HYPITAT-II): a multicentre, open-label randomised controlled trial. ( 21736705 )
2011
5
Prediction of progression to a high risk situation in women with gestational hypertension or mild pre-eclampsia at term. ( 21806572 )
2011
6
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia. ( 20176870 )
2010
7
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. ( 19656558 )
2009
8
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia. ( 15248180 )
2004
9
Methyldopa versus no drug treatment in the management of mild pre-eclampsia. ( 12625668 )
2002
10
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. ( 10492869 )
1999
11
The effect of magnesium sulphate on blood flow velocity in the maternal retina in mild pre-eclampsia: a preliminary colour flow Doppler study. ( 1390468 )
1992
12
Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome. ( 1471910 )
1992
13
Serum proteins in normal pregnancy and mild pre-eclampsia. ( 4104344 )
1971
14
Evaluation of a diuretic substance in the management of mild pre-eclampsia; a report of 47 clinical trials. ( 13595009 )
1958

Variations for Mild Pre-Eclampsia

Expression for Mild Pre-Eclampsia

Search GEO for disease gene expression data for Mild Pre-Eclampsia.

Pathways for Mild Pre-Eclampsia

Pathways related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 SOD1 XDH
2 10.45 SOD1 XDH
3
Show member pathways
9.83 FLT1 PGF

GO Terms for Mild Pre-Eclampsia

Cellular components related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 FLT1 IGFBP1 LEP LNPEP PGF SOD1
2 extracellular space GO:0005615 9.17 FLT1 IGFBP1 LEP PGF SOD1 VCAM1

Biological processes related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.69 FLT1 LEP PGF
2 positive regulation of T cell proliferation GO:0042102 9.55 LEP VCAM1
3 response to nutrient levels GO:0031667 9.54 LEP SOD1
4 aging GO:0007568 9.54 IGFBP1 SOD1 VCAM1
5 placenta development GO:0001890 9.52 LEP SOD1
6 response to hypoxia GO:0001666 9.5 LEP PGF VCAM1
7 positive regulation of cytokine production GO:0001819 9.49 LEP SOD1
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.48 LEP XDH
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.46 FLT1 VCAM1
10 sprouting angiogenesis GO:0002040 9.43 FLT1 PGF
11 positive regulation of p38MAPK cascade GO:1900745 9.4 LEP XDH
12 response to ethanol GO:0045471 9.33 LEP SOD1 VCAM1
13 leukocyte tethering or rolling GO:0050901 9.26 LEP VCAM1
14 female pregnancy GO:0007565 9.13 LEP LNPEP PGF
15 regulation of blood pressure GO:0008217 8.8 LEP LNPEP SOD1

Molecular functions related to Mild Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 FLT1 IGFBP1

Sources for Mild Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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