MCID: MLR025
MIFTS: 19

Miliaria Profunda

Categories: Skin diseases

Aliases & Classifications for Miliaria Profunda

MalaCards integrated aliases for Miliaria Profunda:

Name: Miliaria Profunda 12 15 32
Snomedct_us_2020_03_01:47317002 12
Icd10cm:l74.2 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070320
ICD10 32 L74.2

Summaries for Miliaria Profunda

Disease Ontology : 12 A miliaria that is characterized by ductal occlusion of the papillary dermis causing the gland's secretions to leak between the superficial and deep layers of the skin resulting in a rapidly-spreading flesh-colored rash.

MalaCards based summary : Miliaria Profunda, also known as snomedct_us_2020_03_01:47317002, is related to miliaria rubra and miliaria. An important gene associated with Miliaria Profunda is KRTAP13-1 (Keratin Associated Protein 13-1), and among its related pathways/superpathways are Salivary secretion and Transcriptional Regulatory Network in Embryonic Stem Cell. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Miliaria Profunda

Diseases related to Miliaria Profunda via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 miliaria rubra 10.7
2 miliaria 10.7
3 congenital hypothyroidism 10.2
4 hypothyroidism 10.2
5 gillespie syndrome 9.5 ITPR2 FOXC1
6 miliaria crystallina 8.6 KRTAP13-1 FOXC1 FOXA1 BEST2

Graphical network of the top 20 diseases related to Miliaria Profunda:



Diseases related to Miliaria Profunda

Symptoms & Phenotypes for Miliaria Profunda

GenomeRNAi Phenotypes related to Miliaria Profunda according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.5 FOXA1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.5 FOXA1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.5 FOXA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.5 FOXA1 FOXC1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.5 FOXA1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.5 FOXA1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.5 FOXC1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.5 FOXA1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 9.5 FOXC1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 9.5 FOXA1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.5 FOXA1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.5 FOXA1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.5 FOXA1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.5 FOXC1

MGI Mouse Phenotypes related to Miliaria Profunda:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 BEST2 FOXA1 FOXC1 ITPR2

Drugs & Therapeutics for Miliaria Profunda

Search Clinical Trials , NIH Clinical Center for Miliaria Profunda

Genetic Tests for Miliaria Profunda

Anatomical Context for Miliaria Profunda

MalaCards organs/tissues related to Miliaria Profunda:

40
Skin

Publications for Miliaria Profunda

Articles related to Miliaria Profunda:

# Title Authors PMID Year
1
Granulomatous Variant of Giant Centrifugal Miliaria Profunda in a Hypothyroid Infant: A Case Report. 61
31544077 2019
2
[Widespread miliaria crystallina: about a case]. 61
30344853 2018
3
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. 61
26402230 2016
4
In vivo imaging of miliaria profunda using high-definition optical coherence tomography: diagnosis, pathogenesis, and treatment. 61
25390622 2015
5
Granulomatous variant of giant centrifugal miliaria profunda. 61
22276567 2013
6
Miliaria profunda. 61
8912605 1996
7
"Giant centrifugal miliaria profunda" may be "sweat-related bromoderma". 61
2150435 1990
8
Giant centrifugal miliaria profunda. 61
2359731 1990
9
Transient miliaria profunda and heat incapacitation. 61
13267907 1955
10
Anhidrotic heat exhaustion (anhidrotic asthenia) and mammillaria (miliaria profunda). 61
14876775 1951

Variations for Miliaria Profunda

Expression for Miliaria Profunda

Search GEO for disease gene expression data for Miliaria Profunda.

Pathways for Miliaria Profunda

Pathways related to Miliaria Profunda according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.18 ITPR2 BEST2
2 10.25 ITPR2 FOXC1

GO Terms for Miliaria Profunda

Biological processes related to Miliaria Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure morphogenesis GO:0009653 8.96 FOXC1 FOXA1
2 Notch signaling pathway GO:0007219 8.62 FOXC1 FOXA1

Molecular functions related to Miliaria Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.62 FOXC1 FOXA1

Sources for Miliaria Profunda

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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