MCID: MLR002
MIFTS: 49

Miliary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 12 15 17
Acute Miliary Tuberculosis 12 74
Tuberculosis, Miliary 45 74
Tuberculosis Miliaris Disseminata 12
Disseminated Tuberculosis 12
Tuberculosis Disseminated 56
Generalized Tuberculosis 12
Tuberculosis Miliary 56

Classifications:



External Ids:

Disease Ontology 12 DOID:9861
ICD9CM 36 018 018.9 018.90
MeSH 45 D014391
NCIt 51 C35086
SNOMED-CT 69 47604008
ICD10 34 A19 A19.9

Summaries for Miliary Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary : Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to tuberculous meningitis and meningitis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Th17 cell differentiation and Immune response IL-23 signaling pathway. The drugs BCG vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include spleen, lung and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 30.4 ADA ENO2 TNF
2 meningitis 30.3 ADA IFNG TNF
3 abdominal tuberculosis 29.9 ADA IL12RB1
4 hypersplenism 29.8 EPO IFNG
5 extrapulmonary tuberculosis 29.8 ADA IFNG
6 peritonitis 29.8 ADA MUC16 TNF
7 temporal arteritis 29.8 IFNG TNF
8 human immunodeficiency virus infectious disease 29.7 IFNG TNF
9 acquired immunodeficiency syndrome 29.7 EPO IFNG TNF
10 q fever 29.6 IFNG TNF
11 mycobacterium tuberculosis 1 29.6 ADA IFNG IL12RB1 TNF
12 cryptococcal meningitis 29.6 ADA IFNG
13 melioidosis 29.6 IFNG TNF
14 brucellosis 29.6 IFNG TNF
15 lymphadenitis 29.5 IFNG IL12RB1 TNF
16 listeria meningitis 29.4 ADA TNF
17 aplastic anemia 29.3 EPO IFNG TNF
18 lepromatous leprosy 29.2 IFNG IL12RB1 TNF
19 tuberculous peritonitis 29.2 ADA IFNG MUC16 TNF
20 pericarditis 29.2 ADA IFNG TNF
21 human immunodeficiency virus type 1 28.8 ADA IFNG TNF
22 hemophagocytic lymphohistiocytosis 28.6 ADA ENO2 IFNG TNF
23 pulmonary tuberculosis 28.5 ADA IFNG IL12RB1 TNF
24 adult respiratory distress syndrome 10.5
25 acute respiratory distress syndrome 10.4
26 pneumothorax 10.4
27 lupus erythematosus 10.4
28 pancytopenia 10.3
29 brain injury 10.3 ENO2 EPO
30 meningeal melanomatosis 10.3 ENO2 PDCD1
31 pericardial mesothelioma 10.3 ENO2 MUC16
32 lymphoepithelioma-like carcinoma 10.3 ENO2 PDCD1
33 central nervous system melanocytic neoplasm 10.2 ENO2 PDCD1
34 systemic lupus erythematosus 10.2
35 arthritis 10.2
36 respiratory failure 10.2
37 pneumonia 10.2
38 rheumatoid arthritis 10.2
39 crohn's disease 10.2
40 atopic keratoconjunctivitis 10.2 IFNG MUC16
41 conjunctivitis 10.2 IFNG MUC16
42 primary peritoneal carcinoma 10.2 IFNG MUC16
43 pneumothorax, primary spontaneous 10.2
44 hemangioblastoma 10.1 ENO2 EPO
45 secondary progressive multiple sclerosis 10.1 ENO2 IFNG
46 leukemia 10.1
47 lymphoma 10.1
48 pericardial effusion 10.1 ADA MUC16
49 pericardial tuberculosis 10.1 ADA IFNG
50 cryptococcosis 10.1

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 ADA EPO IFNG IL12RB1 PDCD1 TNF
2 immune system MP:0005387 9.73 ADA EPO IFNG IL12RB1 PDCD1 TNF
3 liver/biliary system MP:0005370 9.55 ADA EPO IFNG PDCD1 TNF
4 muscle MP:0005369 9.35 ADA EPO IFNG PDCD1 TNF
5 respiratory system MP:0005388 9.1 ADA ENO2 EPO IFNG PDCD1 TNF

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 3,Phase 2
2 Vaccines Phase 2, Phase 3,Phase 3
3 Adjuvants, Immunologic Phase 2
4 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigational Vaccine for the Prevention of Disseminated Tuberculosis in HIV Infected People Completed NCT00052195 Phase 2, Phase 3
2 Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda Recruiting NCT02606526 Phase 3
3 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
4 Early Versus Delayed BCG Vaccination of HIV-exposed Infants Completed NCT02062580 Phase 2
5 Evaluating Diagnostics for Paediatric Tuberculosis by Blood Culture Completed NCT01434758
6 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
7 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

MalaCards organs/tissues related to Miliary Tuberculosis:

42
Spleen, Lung, Bone, Bone Marrow, Brain, Liver, T Cells

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 740)
# Title Authors Year
1
Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer. ( 30621812 )
2019
2
ARDS from miliary tuberculosis successfully treated with ECMO. ( 30662828 )
2019
3
A rare case of miliary tuberculosis accompanying perihepatitis. ( 30743325 )
2019
4
Miliary tuberculosis presenting as bilateral superficial femoral artery mycotic aneurysm in an immunocompetent patient. ( 30775239 )
2019
5
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis. ( 30863732 )
2019
6
Miliary tuberculosis induced by intravesical instillation of bacillus Calmette-Guérin. ( 30898332 )
2019
7
Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature. ( 29707591 )
2018
8
Corrigendum to "Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis". ( 29863188 )
2018
9
Miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases: a case report. ( 29338706 )
2018
10
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. ( 29890558 )
2018
11
Can A Sudden Sensorineural Hearing Loss Occur Due to Miliary Tuberculosis? ( 29036759 )
2018
12
Drug-Resistant Miliary Tuberculosis in a Child. ( 29443677 )
2018
13
High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis. ( 29600065 )
2018
14
Strongyloides Hyperinfection and Miliary Tuberculosis Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Malnourished Patient. ( 29796361 )
2018
15
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
16
Surprising pathological and clinical manifestations of miliary tuberculosis. ( 29754134 )
2018
17
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. ( 30246772 )
2018
18
Miliary Tuberculosis in a Crohn's Disease Patient: The Risk beyond the Screening. ( 30675506 )
2018
19
Miliary tuberculosis mimicking systemic lupus erythematosus flare. ( 30237973 )
2018
20
Melioidosis mimicking miliary tuberculosis. ( 30293222 )
2018
21
Comparison of clinical manifestations and treatment outcome according to age groups in adult patients with miliary tuberculosis. ( 29997953 )
2018
22
Contribution of brain imaging to the diagnosis of intracranial tuberculoma and other brain lesions in patients presenting with miliary tuberculosis. ( 30017477 )
2018
23
A challenging case of pelvic inflammatory disease due to miliary tuberculosis. ( 30117595 )
2018
24
Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female. ( 30189694 )
2018
25
Hiding in the bone: a case of miliary tuberculosis with bone marrow involvement. ( 30264032 )
2018
26
Miliary tuberculosis and herpes pharyngitis after a trip to a developing country: dangers of biologics. ( 30279249 )
2018
27
Chronic cutaneous miliary tuberculosis - a forgotten entity. ( 30387135 )
2018
28
Miliary tuberculosis developing during adalimumab treatment for Behçet's disease with uveitis. ( 30567192 )
2018
29
Miliary tuberculosis with pulmonary and extrapulmonary component complicated with acute respiratory distress syndrome. ( 29417038 )
2017
30
Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis. ( 29318053 )
2017
31
High Detection Rates of Urine Mycobacterium tuberculosis in Patients with Suspected Miliary Tuberculosis. ( 28420836 )
2017
32
Diagnosis of miliary tuberculosis in an infant in metropolitan Australia: Detection of infection in 19 further family members,four with pulmonary disease. ( 28940927 )
2017
33
Patterns of ocular inflammation in patients with miliary tuberculosis. ( 28503298 )
2017
34
Efficacy of direct hemoperfusion with a polymyxin B-immobilized fiber column in miliary tuberculosis. ( 29123880 )
2017
35
Miliary tuberculosis: Epidemiologicaland clinical analysis of large-case series from moderate to low tuberculosis endemic Country. ( 28151863 )
2017
36
[Miliary tuberculosis: the role of necropsy studies]. ( 28603236 )
2017
37
Fatal Unusual Miliary Tuberculosis in which a Patient Developed Acute Respiratory Distress Syndrome Induced by Infliximab: An Autopsy Case Report. ( 28458316 )
2017
38
Case report of a lupus patient with a severe flare and miliary tuberculosis: need for proper guidelines for management. ( 28690859 )
2017
39
Miliary tuberculosis infection during hepatitis C treatment with sofosbuvir and ledipasvir plus ribavirin. ( 28217253 )
2017
40
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
41
Miliary tuberculosis with cerebral, liver, prostate and retroesophageal involvement. ( 28560175 )
2017
42
The Diagnostic Yield of Urine Cultures with Liquid Media in Cases of Miliary Tuberculosis. ( 29225259 )
2017
43
Miliary tuberculosis. ( 29087528 )
2017
44
Miliary tuberculosis in a patient with tuberculous mycotic aneurysm of the abdominal aorta: Case report and review of the literature. ( 28377878 )
2017
45
Autopsy findings of miliary tuberculosis in a renal transplant recipient. ( 29043204 )
2017
46
Programmed death-1(+) T cells inhibit effector T cells at the pathological site of miliary tuberculosis. ( 27665733 )
2017
47
Miliary Tuberculosis. ( 28281441 )
2017
48
Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy. ( 28626185 )
2017
49
Disseminated Cryptococcosis Mimicking Miliary Tuberculosis with Generalized Lymphadenopathy in Immunocompetent Host. ( 28782323 )
2017
50
Miliary tuberculosis during adalimumab therapy in Crohn's disease. ( 28743405 )
2017

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 IFNG IL12RB1 TNF
2
Show member pathways
12.29 IFNG IL12RB1 TNF
3 12.27 IFNG PDCD1 TNF
4
Show member pathways
12.06 IFNG PDCD1 TNF
5
Show member pathways
12.04 EPO IFNG IL12RB1
6
Show member pathways
11.61 IFNG IL12RB1 TNF
7 11.4 EPO IFNG TNF
8 11.38 EPO IFNG IL12RB1
9 11.36 IFNG TNF
10 11.27 IFNG TNF
11
Show member pathways
11.26 IFNG TNF
12 11.24 IFNG TNF
13 11.22 IFNG TNF
14 11.21 IFNG TNF
15 11.16 IFNG TNF
16 11.13 ENO2 EPO IFNG
17 11.02 IFNG TNF
18 10.94 IFNG TNF
19 10.87 IFNG TNF
20
Show member pathways
10.83 IFNG IL12RB1
21 10.7 IFNG IL12RB1 TNF

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ADA ENO2 EPO IFNG MUC16 TNF
2 external side of plasma membrane GO:0009897 8.92 ADA IL12RB1 PDCD1 TNF

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase activity GO:0045860 9.55 EPO TNF
2 positive regulation of protein localization to plasma membrane GO:1903078 9.54 IFNG TNF
3 interleukin-12-mediated signaling pathway GO:0035722 9.52 IFNG IL12RB1
4 extrinsic apoptotic signaling pathway GO:0097191 9.51 IFNG TNF
5 positive regulation of interferon-gamma production GO:0032729 9.49 IL12RB1 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.48 IFNG TNF
7 positive regulation of activated T cell proliferation GO:0042104 9.46 EPO IL12RB1
8 positive regulation of protein complex assembly GO:0031334 9.43 IFNG TNF
9 positive regulation of osteoclast differentiation GO:0045672 9.4 IFNG TNF
10 embryonic digestive tract development GO:0048566 9.37 ADA TNF
11 humoral immune response GO:0006959 9.33 IFNG PDCD1 TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 IFNG TNF
13 response to salt stress GO:0009651 9.26 EPO TNF
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IFNG TNF
15 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 EPO IFNG TNF

Sources for Miliary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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