MCID: MLR002
MIFTS: 42

Miliary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 12 15
Acute Miliary Tuberculosis 12 73
Tuberculosis, Miliary 44 73
Tuberculosis Miliaris Disseminata 12
Disseminated Tuberculosis 12
Tuberculosis Disseminated 55
Generalized Tuberculosis 12
Tuberculosis Miliary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9861
ICD10 33 A19 A19.9
ICD9CM 35 018 018.9 018.90
MeSH 44 D014391
NCIt 50 C35086

Summaries for Miliary Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary : Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to tuberculous meningitis and tuberculous peritonitis. An important gene associated with Miliary Tuberculosis is ENO2 (Enolase 2), and among its related pathways/superpathways are Pathways in cancer and Citrate cycle (TCA cycle). The drugs BCG vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotype is respiratory system.

Wikipedia : 76 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 30.7 ADA ENO2
2 tuberculous peritonitis 30.0 ADA MUC16
3 peritonitis 29.9 ADA MUC16
4 abdominal tuberculosis 29.5 ADA IL12RB1
5 pericardial mesothelioma 10.4 ENO2 MUC16
6 brain injury 10.4 ENO2 EPO
7 meningeal melanomatosis 10.4 ENO2 PDCD1
8 lymphoepithelioma-like carcinoma 10.4 ENO2 PDCD1
9 meningitis 10.3
10 hemangioblastoma 10.3 ENO2 EPO
11 adult respiratory distress syndrome 10.3
12 central nervous system melanocytic neoplasm 10.3 ENO2 PDCD1
13 acute respiratory distress syndrome 10.3
14 pneumothorax 10.3
15 pancytopenia 10.2
16 lupus erythematosus 10.1
17 respiratory system cancer 10.1 ENO2 PDCD1
18 arthritis 10.1
19 hepatitis 10.1
20 respiratory failure 10.1
21 choroiditis 10.1
22 systemic lupus erythematosus 10.1
23 rheumatoid arthritis 10.1
24 pneumonia 10.1
25 pneumothorax, primary spontaneous 10.0
26 crohn's disease 10.0
27 intestinal perforation 10.0
28 pleurisy 10.0 ADA MUC16
29 lymphoma 10.0
30 pericardial effusion 10.0 ADA MUC16
31 congenital hemolytic anemia 10.0 ADA EPO
32 leukemia 9.9
33 cryptococcosis 9.9
34 cerebritis 9.9
35 acquired immunodeficiency syndrome 9.9
36 mediastinitis 9.9
37 fasciitis 9.9
38 tenosynovitis 9.9
39 temporal arteritis 9.8
40 glomerulonephritis 9.8
41 osteomyelitis 9.8
42 endocarditis 9.8
43 disseminated intravascular coagulation 9.8
44 bronchopneumonia 9.8
45 prostatitis 9.8
46 lymphadenitis 9.8
47 central nervous system tuberculosis 9.8
48 histoplasmosis 9.8
49 cholecystitis 9.8
50 cellulitis 9.8

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 PDCD1 ADA ENO2 EPO KIF7

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 3,Phase 2
2 Vaccines Phase 2, Phase 3,Phase 3
3 Adjuvants, Immunologic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigational Vaccine for the Prevention of Disseminated Tuberculosis in HIV Infected People Completed NCT00052195 Phase 2, Phase 3
2 Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda Recruiting NCT02606526 Phase 3
3 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
4 Early Versus Delayed BCG Vaccination of HIV-exposed Infants Completed NCT02062580 Phase 2
5 Evaluating Diagnostics for Paediatric Tuberculosis by Blood Culture Completed NCT01434758
6 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
7 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

MalaCards organs/tissues related to Miliary Tuberculosis:

41
Lung, Liver, Bone, Bone Marrow, Skin, T Cells, Testes

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 603)
# Title Authors Year
1
Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature. ( 29707591 )
2018
2
Corrigendum to "Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis". ( 29863188 )
2018
3
Miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases: a case report. ( 29338706 )
2018
4
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. ( 29890558 )
2018
5
Can A Sudden Sensorineural Hearing Loss Occur Due to Miliary Tuberculosis? ( 29036759 )
2018
6
Drug-Resistant Miliary Tuberculosis in a Child. ( 29443677 )
2018
7
High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis. ( 29600065 )
2018
8
Strongyloides Hyperinfection and Miliary Tuberculosis Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Malnourished Patient. ( 29796361 )
2018
9
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
10
Surprising pathological and clinical manifestations of miliary tuberculosis. ( 29754134 )
2018
11
Miliary tuberculosis with pulmonary and extrapulmonary component complicated with acute respiratory distress syndrome. ( 29417038 )
2017
12
Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis. ( 29318053 )
2017
13
High Detection Rates of Urine Mycobacterium tuberculosis in Patients with Suspected Miliary Tuberculosis. ( 28420836 )
2017
14
Diagnosis of miliary tuberculosis in an infant in metropolitan Australia: Detection of infection in 19 further family members,four with pulmonary disease. ( 28940927 )
2017
15
Patterns of ocular inflammation in patients with miliary tuberculosis. ( 28503298 )
2017
16
Efficacy of direct hemoperfusion with a polymyxin B-immobilized fiber column in miliary tuberculosis. ( 29123880 )
2017
17
Miliary tuberculosis: Epidemiologicaland clinical analysis of large-case series from moderate to low tuberculosis endemic Country. ( 28151863 )
2017
18
[Miliary tuberculosis: the role of necropsy studies]. ( 28603236 )
2017
19
Fatal Unusual Miliary Tuberculosis in which a Patient Developed Acute Respiratory Distress Syndrome Induced by Infliximab: An Autopsy Case Report. ( 28458316 )
2017
20
Case report of a lupus patient with a severe flare and miliary tuberculosis: need for proper guidelines for management. ( 28690859 )
2017
21
Miliary tuberculosis infection during hepatitis C treatment with sofosbuvir and ledipasvir plus ribavirin. ( 28217253 )
2017
22
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
23
Miliary tuberculosis with cerebral, liver, prostate and retroesophageal involvement. ( 28560175 )
2017
24
The Diagnostic Yield of Urine Cultures with Liquid Media in Cases of Miliary Tuberculosis. ( 29225259 )
2017
25
Miliary tuberculosis. ( 29087528 )
2017
26
Miliary tuberculosis in a patient with tuberculous mycotic aneurysm of the abdominal aorta: Case report and review of the literature. ( 28377878 )
2017
27
Autopsy findings of miliary tuberculosis in a renal transplant recipient. ( 29043204 )
2017
28
Programmed death-1(+) T cells inhibit effector T cells at the pathological site of miliary tuberculosis. ( 27665733 )
2017
29
Miliary Tuberculosis. ( 28281441 )
2017
30
Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy. ( 28626185 )
2017
31
Disseminated Cryptococcosis Mimicking Miliary Tuberculosis with Generalized Lymphadenopathy in Immunocompetent Host. ( 28782323 )
2017
32
Miliary tuberculosis during adalimumab therapy in Crohn's disease. ( 28743405 )
2017
33
Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort. ( 28427368 )
2017
34
Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review. ( 28626190 )
2017
35
Miliary tuberculosis: sonographic pattern in chest ultrasound. ( 26661658 )
2016
36
Spontaneous Pneumothorax Complicating Miliary Tuberculosis. ( 27876217 )
2016
37
A case of cutaneous tuberculosis: a clue to diagnosing miliary tuberculosis. ( 27383110 )
2016
38
The successful treatment of refractory respiratory failure due to miliary tuberculosis: survival after prolonged extracorporeal membrane oxygenation support. ( 26683127 )
2016
39
Miliary tuberculosis and acquired immunodeficiency syndrome - 'a cursed duet'. ( 27802849 )
2016
40
Congenital miliary tuberculosis in an 18-day-old boy. ( 28018449 )
2016
41
QuantiFERON TB Test in Children With Miliary Tuberculosis. ( 27171581 )
2016
42
Tuberculous Subretinal Abscess in a Non-HIV Patient with Miliary Tuberculosis. ( 28101049 )
2016
43
Cryptic miliary tuberculosis. ( 27435669 )
2016
44
Tuberculous Enteritis: A Rare Complication of Miliary Tuberculosis. ( 27022494 )
2016
45
Miliary tuberculosis in an immunocompetent male with a fatal outcome. ( 27807020 )
2016
46
Infective endocarditis and miliary tuberculosis. ( 27728397 )
2016
47
Peripheral ulcerative keratitis associated with chronic malabsorption syndrome and miliary tuberculosis in a child. ( 27433045 )
2016
48
Response to "Miliary tuberculosis disease complicated by Pott's abscess in an infant: Seven-year follow-up". ( 26933329 )
2016
49
Selective immunoglobulin M deficiency in an adult with miliary tuberculosis: A clinically interesting coexistence. A case report and review of the literature. ( 26928000 )
2016
50
Miliary tuberculosis: a severe opportunistic infection in juvenile systemic lupus erythematosus patients. ( 27267647 )
2016

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 EPO IL12RB1 KIF7
2
Show member pathways
10.97 ENO2 PFKP
3 10.62 ENO2 EPO

GO Terms for Miliary Tuberculosis

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycolytic process GO:0006096 9.16 ENO2 PFKP
2 canonical glycolysis GO:0061621 8.96 ENO2 PFKP
3 positive regulation of activated T cell proliferation GO:0042104 8.62 EPO IL12RB1

Sources for Miliary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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