MCID: MLR002
MIFTS: 52

Miliary Tuberculosis

Categories: Infectious diseases, Respiratory diseases
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Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 11 14 16 75 31 33
Acute Miliary Tuberculosis 11 71
Disseminated Tuberculosis 11 33
Tuberculosis, Miliary 43 71
Disseminated Necrotizing Tuberculosis 33
Disseminated Tuberculous Degeneration 33
Disseminated Necrotic Tuberculosis 33
Tuberculosis Miliaris Disseminata 11
Disseminated Miliary Tuberculosis 33
Disseminated Tuberculous Gangrene 33
Diffuse Necrotizing Tuberculosis 33
Diffuse Tuberculous Degeneration 33
Miliary Tuberculosis Unspecified 33
Diffuse Necrotic Tuberculosis 33
Diffuse Tuberculous Gangrene 33
Mtb - [miliary Tuberculosis] 33
Miliary Tb - [tuberculosis] 33
Tuberculosis Disseminated 53
Generalized Tuberculosis 11
Generalised Tuberculosis 33
Tuberculosis Miliary 53
Miliary Tuberculous 33
Concato Disease 33

Classifications:



External Ids:

Disease Ontology 11 DOID:9861
ICD9CM 34 018
MeSH 43 D014391
NCIt 49 C35086
SNOMED-CT 68 154291001
ICD10 31 A19 A19.2 A19.9
UMLS 71 C0041321 C0152915

Summaries for Miliary Tuberculosis

Disease Ontology: 11 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary: Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to renal tuberculosis and histoplasmosis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs BCG vaccine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include spleen, lung and liver, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: 75 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1248)
# Related Disease Score Top Affiliating Genes
1 renal tuberculosis 30.7 CRP ALB
2 histoplasmosis 30.7 TNF IL12RB1 IFNG CD4
3 central nervous system tuberculosis 30.6 TNF IFNG CRP CD4 ADA
4 disseminated intravascular coagulation 30.6 TNF IL10 GPT CRP
5 cholecystitis 30.6 GPT CRP ALB
6 tuberculous peritonitis 30.5 IFNG CRP ALB ADA
7 hepatic tuberculosis 30.5 GPT ALB
8 polyarteritis nodosa 30.4 TNF GPT CRP
9 extrinsic allergic alveolitis 30.4 TNF CD8A CD4
10 tenosynovitis 30.4 TNF CRP CD8A CD4
11 fasciitis 30.4 TNF IL2 IFNG
12 legionnaire disease 30.3 TNF CRP CD4
13 human immunodeficiency virus type 1 30.3 IL2 IL10 IFNG CD4
14 thrombocytopenia due to platelet alloimmunization 30.3 IL10 CD8A CD4
15 aplastic anemia 30.3 TNF IL4 IL10 IFNG CD8A CD4
16 tuberculous empyema 30.3 ALB ADA
17 inappropriate adh syndrome 30.2 CRP ALB ACE
18 pelvic inflammatory disease 30.2 IL2 IFNG CRP
19 arachnoiditis 30.2 TNF IFNG CRP CD4
20 obstructive jaundice 30.2 GPT CRP ALB
21 pleurisy 30.2 TNF IFNG CRP ADA
22 spondylitis 30.2 TNF IL10 IFNG CRP
23 spontaneous tension pneumothorax 30.2 GPT CRP
24 intracranial abscess 30.1 CRP CD4
25 blastomycosis 30.1 TNF CRP CD4
26 oral candidiasis 30.1 IL12RB1 CD8A CD4
27 ureterolithiasis 30.1 CRP ALB
28 lymphangitis 30.1 CRP CD4 ALB
29 nonspecific interstitial pneumonia 30.1 CRP CD8A CD4
30 pustular psoriasis 30.1 TNF IFNG
31 ocular tuberculosis 30.1 IFNG CD4 ACE
32 tuberculous encephalopathy 30.1 IFNG GPT
33 listeria meningitis 30.1 TNF CD8A
34 portal vein thrombosis 30.1 GPT CRP ALB
35 necrotizing fasciitis 30.1 TNF CRP ALB
36 serum amyloid a amyloidosis 30.1 TNF CRP ALB
37 hepatic coma 30.1 GPT ALB
38 sapho syndrome 30.0 TNF CRP
39 meningitis 30.0 TNF IL4 IL2 IL10 IFNG CRP
40 hepatic encephalopathy 30.0 TNF GPT ALB
41 volvulus of midgut 30.0 GPT CRP ALB
42 pancytopenia 30.0 IFNG GPT CRP CD8A CD4 ALB
43 nocardiosis 30.0 TNF IL12RB1 CRP CD4
44 pericarditis 30.0 TNF IFNG CRP ADA ACE
45 skeletal tuberculosis 30.0 PDE6B IFNG ESX1 CRP
46 axillary adenitis 30.0 IL12RB1 IFNGR1
47 bladder tuberculosis 30.0 PDE6B IFNG ADA
48 lymphopenia 30.0 IL4 IL2 IL10 IFNG ADA
49 acute kidney failure 30.0 GPT ALB ACE
50 marasmus 30.0 CRP CD4 ALB

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE ADA ALB CD4 CRP IFNG
2 endocrine/exocrine gland MP:0005379 10.14 ACE ADA ALB CD4 CD8A IFNG
3 liver/biliary system MP:0005370 10.11 ACE ADA ALB IFNG IFNGR1 IL10
4 cellular MP:0005384 10.1 ACE ADA ALB CD4 CD8A IFNG
5 neoplasm MP:0002006 10.02 ACE ALB IFNG IFNGR1 IL10 IL2
6 digestive/alimentary MP:0005381 10.02 ADA ALB CD4 IFNG IFNGR1 IL10
7 cardiovascular system MP:0005385 10 ACE ADA ALB CRP ESX1 IFNG
8 immune system MP:0005387 9.97 ACE ADA ALB CD4 CD8A CRP
9 hematopoietic system MP:0005397 9.73 ACE ADA CD4 CD8A IFNG IFNGR1
10 integument MP:0010771 9.28 CD4 CD8A IFNG IFNGR1 IL10 IL12RB1

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Approved, Investigational Phase 2, Phase 3
2
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
3
Pyrazinamide Approved, Investigational Phase 3 98-96-4 1046
4
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
5
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
6
Ethambutol Approved Phase 3 74-55-5, 1070-11-7 3279 14052
7
Rifampicin Approved Phase 3 13292-46-1 135512673 5381226 135900090
8
Ofloxacin Approved Phase 3 82419-36-1 4583
9 Vaccines Phase 2, Phase 3
10 Anti-Infective Agents Phase 3
11 Lipid Regulating Agents Phase 3
12 glucocorticoids Phase 3
13 Cytochrome P-450 Enzyme Inhibitors Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Fluoroquinolones Phase 3
16 Antitubercular Agents Phase 3
17 Antimetabolites Phase 3
18 Hormones Phase 3
19 Hormone Antagonists Phase 3
20 Anti-Retroviral Agents Phase 3
21 Antibiotics, Antitubercular Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Anti-Bacterial Agents Phase 3
24 Hypolipidemic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DARDAR Health Project (Disseminated Tuberculosis and HIV Infection) Completed NCT00052195 Phase 2, Phase 3
2 Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis Recruiting NCT04951986 Phase 3 Rifampin;Levofloxacin;Rifampicin, Pyrazinamide, Ethambutol and Isoniazid;Prednisone;Placebo
3 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects in Cape Town, South Africa Unknown status NCT01693224
4 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects Unknown status NCT01525134

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

Organs/tissues related to Miliary Tuberculosis:

MalaCards : Spleen, Lung, Liver, Bone Marrow, Bone, Lymph Node, Brain

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 3589)
# Title Authors PMID Year
1
Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis. 53 62
15736007 2005
2
[Measurement of adenosine deaminase activity in bronchoalveolar lavage fluids as a tool for diagnosing miliary tuberculosis]. 53 62
8622268 1996
3
Clinical analysis of pregnancy complicated with miliary tuberculosis. 62
34955089 2022
4
Disseminated tuberculosis following negative QuantiFERON-TB gold tests during infliximab therapy: Implications for screening of hidradenitis suppurativa. 62
36199671 2022
5
Transverse myelitis in a 26-year-old male with tuberculosis. 62
35936885 2022
6
Disseminated Tuberculosis. 62
35691785 2022
7
Endovascular treatment of a tuberculous aneurysm of the pararenal abdominal aorta leading to an aortoduodenal fistula. 62
36081741 2022
8
Generalized tuberculosis due to Mycobacterium caprae in a red fox phylogenetically related to livestock breakdowns. 62
36127697 2022
9
A Perfect Storm Averted: Flawed Systems, a Dropped Ball, and Cognitive Biases Delay a Critical Diagnosis. 62
36049142 2022
10
Unilateral Choroidal Granuloma and a Pupillary Abnormality in a Case of Miliary Tuberculosis: A Dilemma for the Physician. 62
36204028 2022
11
Disseminated tuberculosis in an immunocompetent state: A case report. 62
36154589 2022
12
Rapidly Evolving and Fatal Miliary Tuberculosis and COVID-19 Infection in an Infant. 62
36261183 2022
13
Double malignancy and a mycobacterial infection in a rheumatoid arthritis patient. 62
36104053 2022
14
Types of Fundus Involvement in Intraocular Tuberculosis. 62
35943072 2022
15
Risk of Reactivation of Latent Tuberculosis in Psoriasis Patients on Biologic Therapies: A Retrospective Cohort from a Tertiary Care Centre in Northern Italy. 62
36065745 2022
16
Disseminated tuberculosis associated with deficient interleukin-23/tyrosine kinase 2 signalling. 62
35999022 2022
17
Clinical Characteristics and Etiological Spectrum of Pancytopenia in Pediatric Age Group: A Cross-Sectional Outlook From a Developing Country. 62
36110464 2022
18
Disseminated Tuberculosis Resulting in Septic Shock in an Immunocompetent Patient. 62
36134051 2022
19
Tuberculous aortic aneurysm developed with miliary tuberculosis. 62
35678564 2022
20
CNS TB-IRIS Following Cessation of Adalimumab in an Adolescent With Crohn's Disease. 62
35949406 2022
21
Non-pulmonary Disseminated Tuberculosis Complicated by Constrictive Pericarditis and Cutaneous Gumma. 62
35501629 2022
22
Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report. 62
35986231 2022
23
Disseminated tuberculosis presenting as bilateral neuro-retinitis. 62
34652442 2022
24
A case of disseminated histoplasmosis mimicking miliary tuberculosis in a VFR with recent travel to Vietnam. 62
35796674 2022
25
Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case. 62
35855351 2022
26
[Clinical features and influencing factors of long-term prognosis in patients with tuberculous meningitis]. 62
35764559 2022
27
Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan. 62
35249818 2022
28
Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis. 62
35763913 2022
29
Does miliary sarcoidosis really exist? A case report and review of the literature. 62
35916806 2022
30
Intestinal perforation due to miliary tuberculosis in a patient with myasthenia gravis. 62
35868806 2022
31
Ruxolitinib and tuberculosis: A case report with brief review. 62
35760486 2022
32
"Tree-in-Bud" appearance in the liver in disseminated tuberculosis. 62
36260457 2022
33
Disseminated tuberculosis masquerading as depression. 62
35876405 2022
34
Disseminated tuberculosis infection in a CAR T-cell recipient. 62
35187816 2022
35
A case of disseminated tuberculosis during a twin pregnancy following in vitro fertilization. 62
35429644 2022
36
Pregnancy in European bison (Bison bonaus) with generalized tuberculosis - no evidence of vertical transmission. 62
35767767 2022
37
'Miliary metastasis' in a child with papillary thyroid cancer. 62
35672061 2022
38
Disseminated tuberculosis following invasive procedures for peripancreatic lymph node tuberculosis with portal vein obstruction: a case report. 62
35334085 2022
39
Disseminated Tuberculosis in a Nigerian Adolescent with Linear IgA Bullous Dermatosis: A Case Report and Review of Literature. 62
35752975 2022
40
Hemophagocytic Lymphohistiocytosis Secondary to Tuberculosis After Liver Transplantation: A Case Report. 62
35597674 2022
41
Mycobacterium tuberculosis transmission in Birmingham, UK, 2009-19: An observational study. 62
35345560 2022
42
A 73-year-old man with loss of consciousness during treatment for miliary tuberculosis. 62
35664634 2022
43
Pathogenesis of tuberculosis: the 1930 Lübeck disaster revisited. 62
35768133 2022
44
Transudative or masked exudative polyserositis in disseminated tuberculosis? A case report. 62
35734705 2022
45
Disseminated granulomatous Pneumocystis jirovecii pneumonia masquerading as miliary tuberculosis. 62
35718842 2022
46
Pulse corticosteroids for the management of extensive CNS tuberculosis presenting with acute-onset quadriparesis. 62
35321986 2022
47
Metastatic cancer masquerading as miliary tuberculosis in an immunocompetent young adult. 62
35609937 2022
48
Disseminated histoplasmosis diagnosed by cross-reactivity with the Aspergillus galactomannan antigen in an HIV-positive patient. 62
35065508 2022
49
An infant of 26 weeks gestation with congenital miliary tuberculosis complicated by chronic lung disease requiring CPAP was diagnosed on Day 104 of life: congenital tuberculosis was confirmed by detection of calcified ovaries in his mother. 62
35588163 2022
50
Abstracts of Presentations at the Association of Clinical Scientists 143rd Meeting Louisville, KY May 11-14,2022. 62
35777803 2022

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 TNF IL4 IL2 IL12RB1 IL10 IFNGR1
2
Show member pathways
13.49 TNF IL4 IL2 IL12RB1 IL10 IFNGR1
3
Show member pathways
13.29 CD4 IFNG IFNGR1 IL10 IL12RB1 IL2
4
Show member pathways
13.23 TNF IL4 IL2 IL12RB1 IL10 CD4
5
Show member pathways
12.63 IFNG IFNGR1 IL10 IL12RB1 IL2 IL4
6
Show member pathways
12.6 TNF IL2 IL12RB1 IL10 IFNG CD4
7 12.58 TNF IL4 IL2 IL10 IFNG CD8A
8
Show member pathways
12.37 TNF IL4 IFNGR1 IFNG
9
Show member pathways
12.18 TNF IL4 IL2 IFNG
10 12.11 TNF IL4 IL10 IFNGR1 IFNG
11 12.04 CD4 CD8A IFNG IL10 IL2 IL4
12
Show member pathways
12.04 CD4 CD8A IFNG IL10 IL12RB1 IL2
13
Show member pathways
12.02 IL4 IL2 IL12RB1 IFNG CD8A CD4
14 11.99 TNF IL4 IL2 IFNG
15 11.91 TNF IL4 IL2 IL10 IFNG
16
Show member pathways
11.91 TNF IL2 IL12RB1 IL10 IFNGR1 IFNG
17 11.9 TNF IL4 IL10
18
Show member pathways
11.88 IL4 IL12RB1 IFNG CD4
19 11.82 TNF IL2 IL10 IFNG CD8A CD4
20 11.79 IL2 IL10 IFNG CD4
21 11.79 TNF IL4 IL2 IL10 IFNG CRP
22
Show member pathways
11.76 TNF IFNGR1 IFNG
23 11.76 CD4 IFNG IFNGR1 IL2 IL4
24
Show member pathways
11.74 CRP CD8A CD4
25 11.74 IL4 IL2 IFNG
26 11.74 IL4 IL2 IL10 IFNG
27
Show member pathways
11.73 TNF IL4 IL2 IFNG
28
Show member pathways
11.64 TNF IL2 IFNG
29 11.57 IFNG IFNGR1 IL2
30 11.57 IL4 IL2 IL10 IFNG CD4
31 11.54 TNF IFNGR1 IFNG
32
Show member pathways
11.47 TNF IL4 IL2 IL12RB1 IL10 IFNGR1
33
Show member pathways
11.42 TNF IL2 IL10 IFNG
34 11.34 IFNG IL2 IL4
35 11.32 TNF IL4 IFNG
36 11.26 TNF IL4 IL2 IL10 IFNG CD4
37 11.25 IL4 IL2 IL10 IFNG
38 11.24 IL2 IFNG CD4
39 11.16 TNF IL4 IL2 IL12RB1 IL10 IFNGR1
40 11.13 TNF IL4 IL2 IL12RB1 IL10 IFNG
41 10.98 IL4 IL2 IL12RB1 IFNG CD4
42 10.68 IL2 IFNG

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.89 TNF IL4 IL2 IL10 IFNG GPT
2 external side of plasma membrane GO:0009897 9.4 TNF IL12RB1 CD8A CD4 ADA ACE

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.27 ADA ALB IL10 IL2 IL4 TNF
2 negative regulation of inflammatory response GO:0050728 10.15 IL4 IL2 IL10 ADA
3 positive regulation of inflammatory response GO:0050729 10.1 ACE IFNG IL2 TNF
4 positive regulation of B cell proliferation GO:0030890 10.07 IL4 IL2 ADA
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.01 TNF IL4 IL2 IFNG
6 T cell differentiation GO:0030217 9.98 IL2 CD4 ADA
7 type 2 immune response GO:0042092 9.92 IL4 IL10
8 neuroinflammatory response GO:0150076 9.91 IL4 IFNG
9 positive regulation of mononuclear cell migration GO:0071677 9.91 TNF IL4
10 positive regulation of amyloid-beta formation GO:1902004 9.91 TNF IFNGR1 IFNG
11 negative regulation of cytokine production involved in immune response GO:0002719 9.9 TNF IL10
12 immune response GO:0006955 9.9 TNF IL4 IL2 IL10 IFNG CD8A
13 positive regulation of T cell differentiation GO:0045582 9.87 IL4 IL2 ADA
14 regulation of isotype switching GO:0045191 9.86 IL4 IL10
15 T cell activation GO:0042110 9.86 IL4 CD8A CD4 ADA
16 astrocyte activation GO:0048143 9.85 TNF IFNGR1 IFNG
17 positive regulation of plasma cell differentiation GO:1900100 9.84 IL2 IL10
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.83 TNF IFNG
19 positive regulation of nitrogen compound metabolic process GO:0051173 9.81 TNF IFNG
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.8 IFNG IL10 IL4
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.78 TNF IFNG
22 chronic inflammatory response to antigenic stimulus GO:0002439 9.76 TNF IL10
23 negative regulation of amyloid-beta clearance GO:1900222 9.43 TNF IFNGR1 IFNG
24 microglial cell activation GO:0001774 9.23 TNF IL4 IFNGR1 IFNG

Molecular functions related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNF IL4 IL2 IL10 IFNG

Sources for Miliary Tuberculosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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