Miliary Tuberculosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to renal tuberculosis and histoplasmosis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs BCG vaccine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include spleen, lung and liver, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: ⁷⁵ Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

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Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1248)

#	Related Disease	Score	Top Affiliating Genes
1	renal tuberculosis	30.7	CRP ALB
2	histoplasmosis	30.7	TNF IL12RB1 IFNG CD4
3	central nervous system tuberculosis	30.6	TNF IFNG CRP CD4 ADA
4	disseminated intravascular coagulation	30.6	TNF IL10 GPT CRP
5	cholecystitis	30.6	GPT CRP ALB
6	tuberculous peritonitis	30.5	IFNG CRP ALB ADA
7	hepatic tuberculosis	30.5	GPT ALB
8	polyarteritis nodosa	30.4	TNF GPT CRP
9	extrinsic allergic alveolitis	30.4	TNF CD8A CD4
10	tenosynovitis	30.4	TNF CRP CD8A CD4
11	fasciitis	30.4	TNF IL2 IFNG
12	legionnaire disease	30.3	TNF CRP CD4
13	human immunodeficiency virus type 1	30.3	IL2 IL10 IFNG CD4
14	thrombocytopenia due to platelet alloimmunization	30.3	IL10 CD8A CD4
15	aplastic anemia	30.3	TNF IL4 IL10 IFNG CD8A CD4
16	tuberculous empyema	30.3	ALB ADA
17	inappropriate adh syndrome	30.2	CRP ALB ACE
18	pelvic inflammatory disease	30.2	IL2 IFNG CRP
19	arachnoiditis	30.2	TNF IFNG CRP CD4
20	obstructive jaundice	30.2	GPT CRP ALB
21	pleurisy	30.2	TNF IFNG CRP ADA
22	spondylitis	30.2	TNF IL10 IFNG CRP
23	spontaneous tension pneumothorax	30.2	GPT CRP
24	intracranial abscess	30.1	CRP CD4
25	blastomycosis	30.1	TNF CRP CD4
26	oral candidiasis	30.1	IL12RB1 CD8A CD4
27	ureterolithiasis	30.1	CRP ALB
28	lymphangitis	30.1	CRP CD4 ALB
29	nonspecific interstitial pneumonia	30.1	CRP CD8A CD4
30	pustular psoriasis	30.1	TNF IFNG
31	ocular tuberculosis	30.1	IFNG CD4 ACE
32	tuberculous encephalopathy	30.1	IFNG GPT
33	listeria meningitis	30.1	TNF CD8A
34	portal vein thrombosis	30.1	GPT CRP ALB
35	necrotizing fasciitis	30.1	TNF CRP ALB
36	serum amyloid a amyloidosis	30.1	TNF CRP ALB
37	hepatic coma	30.1	GPT ALB
38	sapho syndrome	30.0	TNF CRP
39	meningitis	30.0	TNF IL4 IL2 IL10 IFNG CRP
40	hepatic encephalopathy	30.0	TNF GPT ALB
41	volvulus of midgut	30.0	GPT CRP ALB
42	pancytopenia	30.0	IFNG GPT CRP CD8A CD4 ALB
43	nocardiosis	30.0	TNF IL12RB1 CRP CD4
44	pericarditis	30.0	TNF IFNG CRP ADA ACE
45	skeletal tuberculosis	30.0	PDE6B IFNG ESX1 CRP
46	axillary adenitis	30.0	IL12RB1 IFNGR1
47	bladder tuberculosis	30.0	PDE6B IFNG ADA
48	lymphopenia	30.0	IL4 IL2 IL10 IFNG ADA
49	acute kidney failure	30.0	GPT ALB ACE
50	marasmus	30.0	CRP CD4 ALB

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):

Acute Cystitis

Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:

Sources

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	ACE ADA ALB CD4 CRP IFNG
2	endocrine/exocrine gland	MP:0005379	10.14	ACE ADA ALB CD4 CD8A IFNG
3	liver/biliary system	MP:0005370	10.11	ACE ADA ALB IFNG IFNGR1 IL10
4	cellular	MP:0005384	10.1	ACE ADA ALB CD4 CD8A IFNG
5	neoplasm	MP:0002006	10.02	ACE ALB IFNG IFNGR1 IL10 IL2
6	digestive/alimentary	MP:0005381	10.02	ADA ALB CD4 IFNG IFNGR1 IL10
7	cardiovascular system	MP:0005385	10	ACE ADA ALB CRP ESX1 IFNG
8	immune system	MP:0005387	9.97	ACE ADA ALB CD4 CD8A CRP
9	hematopoietic system	MP:0005397	9.73	ACE ADA CD4 CD8A IFNG IFNGR1
10	integument	MP:0010771	9.28	CD4 CD8A IFNG IFNGR1 IL10 IL12RB1

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Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

BCG vaccine

Approved, Investigational

Phase 2, Phase 3

2

Prednisone

Approved, Vet_approved

Phase 3

53-03-2

5865

Synonyms:

1,2-Dehydrocortisone

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

Acis brand OF prednisone

Acsis, prednison

Adasone

Ancortone

Apo-prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Cartancyl

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

Cutason

Dacorten

Dacortin

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

Delta Cortelan

Delta E

Delta-cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Deltacortone

Delta-cortone

DELTA-DOME

Deltasone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

FERNISONE

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

Hoechst brand OF prednisone

Hostacortin

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Lisacort

LODOTRA

Lodotra®|Sterapred®

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Mibe brand OF prednisone

Nisona

Nizon

Novoprednisone

NSC-10023

Nurison

Orasone

Origen Prednisone

Panafcort

Panasol

PARACORT

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

PREDN

Predni tablinen

PREDNICEN-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

PREDNISONE INTENSOL

PREDNISONE TABLETS

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Pronison

Pronisone

RAYOS

Rectodelt

Retrocortine

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

SERVISONE

Solvay brand OF prednisone

Sone

Sterapred

Supercortil

Trommsdorff brand OF prednisone

Ultracorten

Ultracortene

Winpred

Wojtab

Zenadrid

3

Pyrazinamide

Approved, Investigational

Phase 3

98-96-4

1046

4

Isoniazid

Approved, Investigational

Phase 3

54-85-3

3767

Synonyms:

4-Pyridinecarbohydrazide

Acid vanillylidenehydrazide, isonicotinic

Andrazide

Antimicina

Antituberkulosum

Armacide

Armazid

Armazide

Atcotibine

Azuren

Bacillin

Cedin

Cemidon

Chemiazid

Chemidon

Cortinazine

Cotinazin

Cotinizin

Defonin

Dibutin

Diforin

Dinacrin

Ditubin

DOW-ISONIAZID

Ebidene

Eralon

Ertuban

Eutizon

Evalon

Fimalene

FSR 3

Ftivazide

GINK

HIA

Hidranizil

Hidrasonil

Hidrulta

Hidrun

Hycozid

Hydrazid

Hydrazide

Hydrazide, isonicotinic acid

Hyozid

HYZYD

Ido-tebin

Idrazil

Inah

INH

Inizid

Iscotin

Isidrina

Ismazide

Isobicina

Isocid

Isocidene

Isocotin

Isohydrazide

Isolyn

Isonerit

Isonex

Isoniacid

Isoniazid

Isoniazid SA

Isoniazida

Isoniazide

Isonicazide

Isonicid

Isonico

Isonicotan

Isonicotil

Isonicotinate hydrazide

Isonicotinhydrazid

Isonicotinic acid hydrazide

Isonicotinic acid vanillylidenehydrazide

Isonicotinic hydrazide

Isonicotinohydrazide

Isonicotinoyl hydrazide

Isonicotinoylhydrazide

Isonicotinsaeurehydrazid

Isonicotinsäurehydrazid

Isonicotinyl hydrazide

Isonicotinyl hydrazine

Isonicotinylhydrazine

Isonide

Isonidrin

Isonikazid

Isonilex

Isonin

Isonindon

Isonirit

Isoniton

Isonizide

Isopyrin

Isotamine

Isotebe

Isotebezid

Isotinyl

Isozide

Isozyd

Laniazid

Laniozid

Mybasan

Neoteben

Neo-Tizide

Neoxin

Neumandin

Nevin

Niadrin

Nicazide

Nicetal

Nicizina

Niconyl

Nicotibina

NICOTIBINE

Nicotisan

Nicozide

Nidaton

Nidrazid

Nikozid

Niplen

Nitadon

NSC-9659

NYDRAZID

Nyscozid

Pelazid

Percin

Phthisen

Phthivazid

Phthivazide

Pycazide

Pyreazid

Pyricidin

Pyridicin

Pyridine-4-carboxylate hydrazide

Pyridine-4-carboxylic acid hydrazide

Pyrizidin

Raumanon

Razide

Retozide

Rifamate

Rimicid

RIMIFON

Rimiphone

Rimitsid

Robiselin

Robisellin

Roxifen

Sanohidrazina

Sauterazid

Sauterzid

STANOZIDE

TB-Phlogin

TB-Razide

TB-Vis

Tebecid

Tebenic

Tebexin

Tebilon

Tebos

Teebaconin

Tekazin

Tibazide

Tibemid

Tibison

Tibivis

Tibusan

Tubazid

Tubazide

Tubeco

Tubecotubercid

Tuberian

Tubicon

Tubilysin

Tubomel

Tyvid

Unicocyde

Unicozyde

Vanillylidenehydrazide, isonicotinic acid

Vazadrine

Vederon

Zidafimia

Zinadon

Zonazide

5

Levofloxacin

Approved, Investigational

Phase 3

100986-85-4

149096

6

Ethambutol

Approved

Phase 3

74-55-5, 1070-11-7

3279 14052

7

Rifampicin

Approved

Phase 3

13292-46-1

135512673 5381226 135900090

8

Ofloxacin

Approved

Phase 3

82419-36-1

4583

9

Vaccines

Phase 2, Phase 3

10

Anti-Infective Agents

Phase 3

11

Lipid Regulating Agents

Phase 3

12

glucocorticoids

Phase 3

13

Cytochrome P-450 Enzyme Inhibitors

Phase 3

14

Antineoplastic Agents, Hormonal

Phase 3

15

Fluoroquinolones

Phase 3

16

Antitubercular Agents

Phase 3

17

Antimetabolites

Phase 3

18

Hormones

Phase 3

19

Hormone Antagonists

Phase 3

20

Anti-Retroviral Agents

Phase 3

21

Antibiotics, Antitubercular

Phase 3

22

Anti-Inflammatory Agents

Phase 3

23

Anti-Bacterial Agents

Phase 3

24

Hypolipidemic Agents

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	DARDAR Health Project (Disseminated Tuberculosis and HIV Infection)	Completed	NCT00052195	Phase 2, Phase 3
2	Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis	Recruiting	NCT04951986	Phase 3	Rifampin;Levofloxacin;Rifampicin, Pyrazinamide, Ethambutol and Isoniazid;Prednisone;Placebo
3	Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects in Cape Town, South Africa	Unknown status	NCT01693224
4	Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects	Unknown status	NCT01525134

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

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Genetic Tests for Miliary Tuberculosis

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Anatomical Context for Miliary Tuberculosis

Organs/tissues related to Miliary Tuberculosis:

MalaCards : Spleen, Lung, Liver, Bone Marrow, Bone, Lymph Node, Brain

Sources

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 3589)

#	Title	Authors	PMID	Year
1	Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis. ⁵³ ⁶²	Ozbek N...Casanova JL	15736007	2005
2	[Measurement of adenosine deaminase activity in bronchoalveolar lavage fluids as a tool for diagnosing miliary tuberculosis]. ⁵³ ⁶²	Kubota M...Tomita T	8622268	1996
3	Clinical analysis of pregnancy complicated with miliary tuberculosis. ⁶²	Wang K...Li W	34955089	2022
4	Disseminated tuberculosis following negative QuantiFERON-TB gold tests during infliximab therapy: Implications for screening of hidradenitis suppurativa. ⁶²	Ntiri M...Lowenstein EJ	36199671	2022
5	Transverse myelitis in a 26-year-old male with tuberculosis. ⁶²	Harizi E...Ahmetgjekaj I	35936885	2022
6	Disseminated Tuberculosis. ⁶²	Teco-Cortes JA...Lazos-Ochoa M	35691785	2022
7	Endovascular treatment of a tuberculous aneurysm of the pararenal abdominal aorta leading to an aortoduodenal fistula. ⁶²	Azuma S...Yasuyoshi Y	36081741	2022
8	Generalized tuberculosis due to Mycobacterium caprae in a red fox phylogenetically related to livestock breakdowns. ⁶²	Perez de Val B...Velarde R	36127697	2022
9	A Perfect Storm Averted: Flawed Systems, a Dropped Ball, and Cognitive Biases Delay a Critical Diagnosis. ⁶²	Roberts TJ...Jacobson JO	36049142	2022
10	Unilateral Choroidal Granuloma and a Pupillary Abnormality in a Case of Miliary Tuberculosis: A Dilemma for the Physician. ⁶²	Jojo V...Ahmad R	36204028	2022
11	Disseminated tuberculosis in an immunocompetent state: A case report. ⁶²	Singh J...Kumar K	36154589	2022
12	Rapidly Evolving and Fatal Miliary Tuberculosis and COVID-19 Infection in an Infant. ⁶²	Ghosh A...Bhattacharjee M	36261183	2022
13	Double malignancy and a mycobacterial infection in a rheumatoid arthritis patient. ⁶²	AlFaris H...Alokaily F	36104053	2022
14	Types of Fundus Involvement in Intraocular Tuberculosis. ⁶²	Kaya M...Saatci AO	35943072	2022
15	Risk of Reactivation of Latent Tuberculosis in Psoriasis Patients on Biologic Therapies: A Retrospective Cohort from a Tertiary Care Centre in Northern Italy. ⁶²	Mastorino L...Quaglino P	36065745	2022
16	Disseminated tuberculosis associated with deficient interleukin-23/tyrosine kinase 2 signalling. ⁶²	Ojuawo O...Piracha S	35999022	2022
17	Clinical Characteristics and Etiological Spectrum of Pancytopenia in Pediatric Age Group: A Cross-Sectional Outlook From a Developing Country. ⁶²	Zubair AB...Kaneez M	36110464	2022
18	Disseminated Tuberculosis Resulting in Septic Shock in an Immunocompetent Patient. ⁶²	Jaffet MF...Wahoo W	36134051	2022
19	Tuberculous aortic aneurysm developed with miliary tuberculosis. ⁶²	Tanaka S...Otsuka F	35678564	2022
20	CNS TB-IRIS Following Cessation of Adalimumab in an Adolescent With Crohn's Disease. ⁶²	Christian E...Johnston A	35949406	2022
21	Non-pulmonary Disseminated Tuberculosis Complicated by Constrictive Pericarditis and Cutaneous Gumma. ⁶²	Rustad AM...Bhasin A	35501629	2022
22	Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report. ⁶²	Bednarova K...Viklicky O	35986231	2022
23	Disseminated tuberculosis presenting as bilateral neuro-retinitis. ⁶²	Anton-Vazquez V...Arias M	34652442	2022
24	A case of disseminated histoplasmosis mimicking miliary tuberculosis in a VFR with recent travel to Vietnam. ⁶²	Mah J...Vaughan S	35796674	2022
25	Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case. ⁶²	Letchuman V...Camarata PJ	35855351	2022
26	[Clinical features and influencing factors of long-term prognosis in patients with tuberculous meningitis]. ⁶²	Yang ZR...Liu XQ	35764559	2022
27	Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan. ⁶²	Oshima K...Kaku M	35249818	2022
28	Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis. ⁶²	Davuluri KS...Chauhan DS	35763913	2022
29	Does miliary sarcoidosis really exist? A case report and review of the literature. ⁶²	Kasikovic Lecic S...Zivanovic D	35916806	2022
30	Intestinal perforation due to miliary tuberculosis in a patient with myasthenia gravis. ⁶²	Morgan AA...Kon OM	35868806	2022
31	Ruxolitinib and tuberculosis: A case report with brief review. ⁶²	Tiwari N...Tripathi AK	35760486	2022
32	"Tree-in-Bud" appearance in the liver in disseminated tuberculosis. ⁶²	Bhatia H...Gupta P	36260457	2022
33	Disseminated tuberculosis masquerading as depression. ⁶²	Riaz R M...Umakanth S	35876405	2022
34	Disseminated tuberculosis infection in a CAR T-cell recipient. ⁶²	Grasa C...Perez-Martinez A	35187816	2022
35	A case of disseminated tuberculosis during a twin pregnancy following in vitro fertilization. ⁶²	Kestens L...Van Braeckel E	35429644	2022
36	Pregnancy in European bison (Bison bonaus) with generalized tuberculosis - no evidence of vertical transmission. ⁶²	Didkowska A...Anusz K	35767767	2022
37	'Miliary metastasis' in a child with papillary thyroid cancer. ⁶²	Gie A...Goussard P	35672061	2022
38	Disseminated tuberculosis following invasive procedures for peripancreatic lymph node tuberculosis with portal vein obstruction: a case report. ⁶²	Kato A...Motomura Y	35334085	2022
39	Disseminated Tuberculosis in a Nigerian Adolescent with Linear IgA Bullous Dermatosis: A Case Report and Review of Literature. ⁶²	Gobir AA...Folaranmi OO	35752975	2022
40	Hemophagocytic Lymphohistiocytosis Secondary to Tuberculosis After Liver Transplantation: A Case Report. ⁶²	Ferreira GSA...Couto CF	35597674	2022
41	Mycobacterium tuberculosis transmission in Birmingham, UK, 2009-19: An observational study. ⁶²	Walker TM...Peto TEA	35345560	2022
42	A 73-year-old man with loss of consciousness during treatment for miliary tuberculosis. ⁶²	Ohgiya M...Matsui H	35664634	2022
43	Pathogenesis of tuberculosis: the 1930 Lübeck disaster revisited. ⁶²	Donald P...Lange C	35768133	2022
44	Transudative or masked exudative polyserositis in disseminated tuberculosis? A case report. ⁶²	Dhakal B...Thapa D	35734705	2022
45	Disseminated granulomatous Pneumocystis jirovecii pneumonia masquerading as miliary tuberculosis. ⁶²	Matsuo K...Ikura Y	35718842	2022
46	Pulse corticosteroids for the management of extensive CNS tuberculosis presenting with acute-onset quadriparesis. ⁶²	Arora U...Biswas A	35321986	2022
47	Metastatic cancer masquerading as miliary tuberculosis in an immunocompetent young adult. ⁶²	Ng PY...Batista C	35609937	2022
48	Disseminated histoplasmosis diagnosed by cross-reactivity with the Aspergillus galactomannan antigen in an HIV-positive patient. ⁶²	Ghorra N...Deyi VYM	35065508	2022
49	An infant of 26 weeks gestation with congenital miliary tuberculosis complicated by chronic lung disease requiring CPAP was diagnosed on Day 104 of life: congenital tuberculosis was confirmed by detection of calcified ovaries in his mother. ⁶²	Matsuda A...Shimizu T	35588163	2022
50	Abstracts of Presentations at the Association of Clinical Scientists 143rd Meeting Louisville, KY May 11-14,2022. ⁶²		35777803	2022

Sources

Genes for Miliary Tuberculosis

Genes related to Miliary Tuberculosis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	12.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15736007
2	ADA	Adenosine Deaminase	Protein Coding	11.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8622268
3	CD4	CD4 Molecule	Protein Coding	7.2	DISEASES inferred ¹⁴
4	IFNG	Interferon Gamma	Protein Coding	6.76	DISEASES inferred ¹⁴
5	CRP	C-Reactive Protein	Protein Coding	6.49	DISEASES inferred ¹⁴
6	TNF	Tumor Necrosis Factor	Protein Coding	6.17	DISEASES inferred ¹⁴
7	CD8A	CD8a Molecule	Protein Coding	5.94	DISEASES inferred ¹⁴
8	ALB	Albumin	Protein Coding	5.75	DISEASES inferred ¹⁴
9	PDE6B	Phosphodiesterase 6B	Protein Coding	5.42	DISEASES inferred ¹⁴
10	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.32	DISEASES inferred ¹⁴
11	IL2	Interleukin 2	Protein Coding	5.28	DISEASES inferred ¹⁴
12	ESX1	ESX Homeobox 1	Protein Coding	5.1	DISEASES inferred ¹⁴
13	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	5.1	DISEASES inferred ¹⁴
14	IL10	Interleukin 10	Protein Coding	5.07	DISEASES inferred ¹⁴
15	ACE	Angiotensin I Converting Enzyme	Protein Coding	4.98	DISEASES inferred ¹⁴
16	IL4	Interleukin 4	Protein Coding	4.94	DISEASES inferred ¹⁴

Sources

Variations for Miliary Tuberculosis

Sources

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Sources

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 42)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.91	TNF IL4 IL2 IL12RB1 IL10 IFNGR1
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.49	TNF IL4 IL2 IL12RB1 IL10 IFNGR1
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.29	CD4 IFNG IFNGR1 IL10 IL12RB1 IL2
4	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.23	TNF IL4 IL2 IL12RB1 IL10 CD4
5	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.63	IFNG IFNGR1 IL10 IL12RB1 IL2 IL4
6	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.6	TNF IL2 IL12RB1 IL10 IFNG CD4
7	NF-kappaB Signaling ³	12.58	TNF IL4 IL2 IL10 IFNG CD8A
8	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.37	TNF IL4 IFNGR1 IFNG
9	Immune response CD16 signaling in NK cells ²² Show member pathways Immune response Role of DAP12 receptors in NK cells ²²	12.18	TNF IL4 IL2 IFNG
10	Neuroinflammation and glutamatergic signaling ⁷⁴	12.11	TNF IL4 IL10 IFNGR1 IFNG
11	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.04	CD4 CD8A IFNG IL10 IL2 IL4
12	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.04	CD4 CD8A IFNG IL10 IL12RB1 IL2
13	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.02	IL4 IL2 IL12RB1 IFNG CD8A CD4
14	Spinal cord injury ⁷⁴	11.99	TNF IL4 IL2 IFNG
15	Allograft rejection ⁷⁴	11.91	TNF IL4 IL2 IL10 IFNG
16	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.91	TNF IL2 IL12RB1 IL10 IFNGR1 IFNG
17	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.9	TNF IL4 IL10
18	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.88	IL4 IL12RB1 IFNG CD4
19	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.82	TNF IL2 IL10 IFNG CD8A CD4
20	Acute viral myocarditis ⁷⁴	11.79	IL2 IL10 IFNG CD4
21	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.79	TNF IL4 IL2 IL10 IFNG CRP
22	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.76	TNF IFNGR1 IFNG
23	Th17 cell differentiation pathway ⁷⁴	11.76	CD4 IFNG IFNGR1 IL2 IL4
24	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.74	CRP CD8A CD4
25	Glucocorticoid receptor regulatory network ⁶¹	11.74	IL4 IL2 IFNG
26	AP-1 transcription factor network ⁶¹	11.74	IL4 IL2 IL10 IFNG
27	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.73	TNF IL4 IL2 IFNG
28	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.64	TNF IL2 IFNG
29	SHP2 signaling ⁶¹	11.57	IFNG IFNGR1 IL2
30	Th2 Differentiation ⁶⁵	11.57	IL4 IL2 IL10 IFNG CD4
31	"Non-genomic actions of 1,25 dihydroxyvitamin D3" ⁷⁴	11.54	TNF IFNGR1 IFNG
32	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.47	TNF IL4 IL2 IL12RB1 IL10 IFNGR1
33	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.42	TNF IL2 IL10 IFNG
34	Inflammatory response pathway ⁷⁴	11.34	IFNG IL2 IL4
35	Development and heterogeneity of the ILC family ⁷⁴	11.32	TNF IL4 IFNG
36	Cytokines and inflammatory response ⁷⁴	11.26	TNF IL4 IL2 IL10 IFNG CD4
37	OX40 Pathway ⁶⁴	11.25	IL4 IL2 IL10 IFNG
38	IL12 signaling mediated by STAT4 ⁶¹	11.24	IL2 IFNG CD4
39	THC Differentiation Pathway ⁶⁴	11.16	TNF IL4 IL2 IL12RB1 IL10 IFNGR1
40	Innate Lymphoid Cells Differentiation ⁶⁵	11.13	TNF IL4 IL2 IL12RB1 IL10 IFNG
41	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.98	IL4 IL2 IL12RB1 IFNG CD4
42	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) ⁶⁶	10.68	IL2 IFNG

Sources

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.89	TNF IL4 IL2 IL10 IFNG GPT
2	external side of plasma membrane	GO:0009897	9.4	TNF IL12RB1 CD8A CD4 ADA ACE

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10.27	ADA ALB IL10 IL2 IL4 TNF
2	negative regulation of inflammatory response	GO:0050728	10.15	IL4 IL2 IL10 ADA
3	positive regulation of inflammatory response	GO:0050729	10.1	ACE IFNG IL2 TNF
4	positive regulation of B cell proliferation	GO:0030890	10.07	IL4 IL2 ADA
5	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.01	TNF IL4 IL2 IFNG
6	T cell differentiation	GO:0030217	9.98	IL2 CD4 ADA
7	type 2 immune response	GO:0042092	9.92	IL4 IL10
8	neuroinflammatory response	GO:0150076	9.91	IL4 IFNG
9	positive regulation of mononuclear cell migration	GO:0071677	9.91	TNF IL4
10	positive regulation of amyloid-beta formation	GO:1902004	9.91	TNF IFNGR1 IFNG
11	negative regulation of cytokine production involved in immune response	GO:0002719	9.9	TNF IL10
12	immune response	GO:0006955	9.9	TNF IL4 IL2 IL10 IFNG CD8A
13	positive regulation of T cell differentiation	GO:0045582	9.87	IL4 IL2 ADA
14	regulation of isotype switching	GO:0045191	9.86	IL4 IL10
15	T cell activation	GO:0042110	9.86	IL4 CD8A CD4 ADA
16	astrocyte activation	GO:0048143	9.85	TNF IFNGR1 IFNG
17	positive regulation of plasma cell differentiation	GO:1900100	9.84	IL2 IL10
18	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.83	TNF IFNG
19	positive regulation of nitrogen compound metabolic process	GO:0051173	9.81	TNF IFNG
20	positive regulation of MHC class II biosynthetic process	GO:0045348	9.8	IFNG IL10 IL4
21	positive regulation of vitamin D biosynthetic process	GO:0060557	9.78	TNF IFNG
22	chronic inflammatory response to antigenic stimulus	GO:0002439	9.76	TNF IL10
23	negative regulation of amyloid-beta clearance	GO:1900222	9.43	TNF IFNGR1 IFNG
24	microglial cell activation	GO:0001774	9.23	TNF IL4 IFNGR1 IFNG

Molecular functions related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.32	TNF IL4 IL2 IL10 IFNG

Sources

Sources for Miliary Tuberculosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MLR002 MIFTS: 52	Miliary Tuberculosis Categories: Infectious diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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