MCID: MLR002
MIFTS: 48

Miliary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 12 15
Acute Miliary Tuberculosis 12 73
Tuberculosis, Miliary 44 73
Tuberculosis Miliaris Disseminata 12
Disseminated Tuberculosis 12
Tuberculosis Disseminated 55
Generalized Tuberculosis 12
Tuberculosis Miliary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9861
ICD10 33 A19 A19.9
ICD9CM 35 018 018.9 018.90
MeSH 44 D014391
NCIt 50 C35086
SNOMED-CT 68 47604008

Summaries for Miliary Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary : Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to tuberculous meningitis and meningitis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Pathways in cancer and T cell receptor signaling pathway. The drugs BCG vaccine and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and spleen, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 30.7 ADA ENO2 TNF
2 meningitis 30.4 ADA IFNG TNF
3 peritonitis 30.1 ADA MUC16 TNF
4 abdominal tuberculosis 29.9 ADA IL12RB1
5 acquired immunodeficiency syndrome 29.8 EPO IFNG TNF
6 human immunodeficiency virus infectious disease 29.7 IFNG TNF
7 mycobacterium tuberculosis 1 29.7 ADA IFNG IL12RB1 TNF
8 extrapulmonary tuberculosis 29.6 ADA IFNG
9 lymphadenitis 29.6 IFNG IL12RB1 TNF
10 q fever 29.6 IFNG TNF
11 listeria meningitis 29.6 ADA TNF
12 melioidosis 29.5 IFNG TNF
13 hypersplenism 29.5 EPO IFNG
14 brucellosis 29.5 IFNG TNF
15 tuberculous peritonitis 29.5 ADA IFNG MUC16 TNF
16 cryptococcal meningitis 29.4 ADA IFNG
17 aplastic anemia 29.4 EPO IFNG TNF
18 lepromatous leprosy 29.4 IFNG IL12RB1 TNF
19 pericarditis 29.3 ADA IFNG TNF
20 temporal arteritis 29.3 IFNG TNF
21 pulmonary tuberculosis 28.9 ADA IFNG IL12RB1 TNF
22 adult respiratory distress syndrome 10.5
23 pneumothorax 10.4
24 lupus erythematosus 10.4
25 acute respiratory distress syndrome 10.4
26 pancytopenia 10.3
27 systemic lupus erythematosus 10.2
28 respiratory failure 10.2
29 pneumonia 10.2
30 arthritis 10.2
31 meningeal melanomatosis 10.2 ENO2 PDCD1
32 lymphoepithelioma-like carcinoma 10.2 ENO2 PDCD1
33 pericardial mesothelioma 10.2 ENO2 MUC16
34 brain injury 10.2 ENO2 EPO
35 central nervous system melanocytic neoplasm 10.2 ENO2 PDCD1
36 pneumothorax, primary spontaneous 10.2
37 rheumatoid arthritis 10.2
38 crohn's disease 10.2
39 leukemia 10.1
40 lymphoma 10.1
41 poems syndrome 10.1 EPO TNF
42 opisthorchiasis 10.1 MUC16 TNF
43 periventricular leukomalacia 10.1 EPO TNF
44 pericardial effusion 10.1 ADA MUC16
45 sympathetic ophthalmia 10.1 PDCD1 TNF
46 appendicitis 10.1 ENO2 TNF
47 hidradenitis suppurativa 10.1 IL12RB1 TNF
48 cryptococcosis 10.1
49 central nervous system tuberculosis 10.1
50 intestinal perforation 10.1

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 ADA ENO2 EPO IFNG KIF7 PDCD1
2 cardiovascular system MP:0005385 9.88 ADA EPO IFNG KIF7 PDCD1 TNF
3 growth/size/body region MP:0005378 9.87 ADA ENO2 IFNG IL12RB1 KIF7 PDCD1
4 liver/biliary system MP:0005370 9.65 ADA EPO IFNG PDCD1 TNF
5 muscle MP:0005369 9.63 ADA EPO IFNG KIF7 PDCD1 TNF
6 respiratory system MP:0005388 9.5 ADA ENO2 EPO IFNG KIF7 PDCD1
7 skeleton MP:0005390 9.1 ADA EPO IFNG KIF7 PDCD1 TNF

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 2
2 Adjuvants, Immunologic Phase 2
3 Vaccines Phase 2
4 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
2 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

MalaCards organs/tissues related to Miliary Tuberculosis:

41
Liver, Lung, Spleen, Bone, Bone Marrow, Brain, Kidney

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 732)
# Title Authors Year
1
Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature. ( 29707591 )
2018
2
Corrigendum to "Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis". ( 29863188 )
2018
3
Miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases: a case report. ( 29338706 )
2018
4
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. ( 29890558 )
2018
5
Can A Sudden Sensorineural Hearing Loss Occur Due to Miliary Tuberculosis? ( 29036759 )
2018
6
Drug-Resistant Miliary Tuberculosis in a Child. ( 29443677 )
2018
7
High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis. ( 29600065 )
2018
8
Strongyloides Hyperinfection and Miliary Tuberculosis Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Malnourished Patient. ( 29796361 )
2018
9
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
10
Surprising pathological and clinical manifestations of miliary tuberculosis. ( 29754134 )
2018
11
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. ( 30246772 )
2018
12
Miliary tuberculosis mimicking systemic lupus erythematosus flare. ( 30237973 )
2018
13
Melioidosis mimicking miliary tuberculosis. ( 30293222 )
2018
14
Comparison of clinical manifestations and treatment outcome according to age groups in adult patients with miliary tuberculosis. ( 29997953 )
2018
15
Contribution of brain imaging to the diagnosis of intracranial tuberculoma and other brain lesions in patients presenting with miliary tuberculosis. ( 30017477 )
2018
16
A challenging case of pelvic inflammatory disease due to miliary tuberculosis. ( 30117595 )
2018
17
Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female. ( 30189694 )
2018
18
Hiding in the bone: a case of miliary tuberculosis with bone marrow involvement. ( 30264032 )
2018
19
Miliary tuberculosis and herpes pharyngitis after a trip to a developing country: dangers of biologics. ( 30279249 )
2018
20
Chronic cutaneous miliary tuberculosis - a forgotten entity. ( 30387135 )
2018
21
Miliary tuberculosis with pulmonary and extrapulmonary component complicated with acute respiratory distress syndrome. ( 29417038 )
2017
22
Miliary Tuberculosis Presenting with ARDS and Shock: A Case Report and Challenges in Current Management and Diagnosis. ( 29318053 )
2017
23
High Detection Rates of Urine Mycobacterium tuberculosis in Patients with Suspected Miliary Tuberculosis. ( 28420836 )
2017
24
Diagnosis of miliary tuberculosis in an infant in metropolitan Australia: Detection of infection in 19 further family members,four with pulmonary disease. ( 28940927 )
2017
25
Patterns of ocular inflammation in patients with miliary tuberculosis. ( 28503298 )
2017
26
Efficacy of direct hemoperfusion with a polymyxin B-immobilized fiber column in miliary tuberculosis. ( 29123880 )
2017
27
Miliary tuberculosis: Epidemiologicaland clinical analysis of large-case series from moderate to low tuberculosis endemic Country. ( 28151863 )
2017
28
[Miliary tuberculosis: the role of necropsy studies]. ( 28603236 )
2017
29
Fatal Unusual Miliary Tuberculosis in which a Patient Developed Acute Respiratory Distress Syndrome Induced by Infliximab: An Autopsy Case Report. ( 28458316 )
2017
30
Case report of a lupus patient with a severe flare and miliary tuberculosis: need for proper guidelines for management. ( 28690859 )
2017
31
Miliary tuberculosis infection during hepatitis C treatment with sofosbuvir and ledipasvir plus ribavirin. ( 28217253 )
2017
32
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
33
Miliary tuberculosis with cerebral, liver, prostate and retroesophageal involvement. ( 28560175 )
2017
34
The Diagnostic Yield of Urine Cultures with Liquid Media in Cases of Miliary Tuberculosis. ( 29225259 )
2017
35
Miliary tuberculosis. ( 29087528 )
2017
36
Miliary tuberculosis in a patient with tuberculous mycotic aneurysm of the abdominal aorta: Case report and review of the literature. ( 28377878 )
2017
37
Autopsy findings of miliary tuberculosis in a renal transplant recipient. ( 29043204 )
2017
38
Programmed death-1(+) T cells inhibit effector T cells at the pathological site of miliary tuberculosis. ( 27665733 )
2017
39
Miliary Tuberculosis. ( 28281441 )
2017
40
Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy. ( 28626185 )
2017
41
Disseminated Cryptococcosis Mimicking Miliary Tuberculosis with Generalized Lymphadenopathy in Immunocompetent Host. ( 28782323 )
2017
42
Miliary tuberculosis during adalimumab therapy in Crohn's disease. ( 28743405 )
2017
43
Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort. ( 28427368 )
2017
44
Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review. ( 28626190 )
2017
45
Miliary tuberculosis: sonographic pattern in chest ultrasound. ( 26661658 )
2016
46
Spontaneous Pneumothorax Complicating Miliary Tuberculosis. ( 27876217 )
2016
47
A case of cutaneous tuberculosis: a clue to diagnosing miliary tuberculosis. ( 27383110 )
2016
48
The successful treatment of refractory respiratory failure due to miliary tuberculosis: survival after prolonged extracorporeal membrane oxygenation support. ( 26683127 )
2016
49
Miliary tuberculosis and acquired immunodeficiency syndrome - 'a cursed duet'. ( 27802849 )
2016
50
Congenital miliary tuberculosis in an 18-day-old boy. ( 28018449 )
2016

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.39 EPO IFNG IL12RB1 KIF7
2
Show member pathways
12.08 IFNG PDCD1 TNF
3
Show member pathways
12.07 EPO IFNG IL12RB1
4
Show member pathways
11.61 IFNG IL12RB1 TNF
5 11.4 EPO IFNG TNF
6 11.38 EPO IFNG IL12RB1
7 11.28 IFNG TNF
8
Show member pathways
11.27 IFNG TNF
9 11.25 IFNG TNF
10 11.23 IFNG TNF
11 11.22 IFNG TNF
12 11.16 IFNG TNF
13 11.13 ENO2 EPO IFNG
14 11.02 IFNG TNF
15 10.96 IFNG TNF
16 10.9 IFNG TNF
17
Show member pathways
10.87 IFNG IL12RB1
18 10.7 IFNG IL12RB1 TNF

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ADA ENO2 EPO IFNG MUC16 TNF
2 external side of plasma membrane GO:0009897 8.92 ADA IL12RB1 PDCD1 TNF

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 interleukin-12-mediated signaling pathway GO:0035722 9.54 IFNG IL12RB1
2 extrinsic apoptotic signaling pathway GO:0097191 9.52 IFNG TNF
3 positive regulation of interferon-gamma production GO:0032729 9.51 IL12RB1 TNF
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.49 IFNG TNF
5 positive regulation of activated T cell proliferation GO:0042104 9.48 EPO IL12RB1
6 positive regulation of protein complex assembly GO:0031334 9.46 IFNG TNF
7 protein import into nucleus, translocation GO:0000060 9.43 IFNG TNF
8 positive regulation of osteoclast differentiation GO:0045672 9.4 IFNG TNF
9 embryonic digestive tract development GO:0048566 9.37 ADA TNF
10 humoral immune response GO:0006959 9.33 IFNG PDCD1 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 IFNG TNF
12 response to salt stress GO:0009651 9.26 EPO TNF
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IFNG TNF
14 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 EPO IFNG TNF

Sources for Miliary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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