MCID: MLR002
MIFTS: 49

Miliary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 12 15 17 32
Acute Miliary Tuberculosis 12 71
Tuberculosis, Miliary 43 71
Tuberculosis Miliaris Disseminata 12
Disseminated Tuberculosis 12
Tuberculosis Disseminated 54
Generalized Tuberculosis 12
Tuberculosis Miliary 54

Classifications:



External Ids:

Disease Ontology 12 DOID:9861
ICD9CM 34 018 018.9 018.90
MeSH 43 D014391
NCIt 49 C35086
SNOMED-CT 67 47604008
ICD10 32 A19 A19.2 A19.9
UMLS 71 C0041321 C0152915

Summaries for Miliary Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary : Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to tuberculous meningitis and central nervous system tuberculosis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs BCG vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 905)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 31.4 TNF ENO2 ADA
2 central nervous system tuberculosis 30.6 CD4 ADA
3 secondary hemophagocytic lymphohistiocytosis 30.5 TNF ADA
4 lymph node tuberculosis 30.3 IFNG CD4
5 axillary adenitis 30.3 IL12RB1 IFNG
6 respiratory failure 30.2 TNF EPO CRP CD4 ALB
7 osteomyelitis 30.2 TNF IFNG CSF3
8 purpura 30.1 TNF CRP CD40LG
9 constrictive pericarditis 30.1 CRP ALB ADA
10 pulmonary edema 30.0 TNF EPO CSF3 CRP
11 keratitis, hereditary 30.0 TNF CD8A CD4
12 cryptococcosis 29.9 TNF IFNG CD8A CD4
13 mucormycosis 29.9 IFNG CSF3 CD4
14 melioidosis 29.9 TNF IFNG CSF3
15 iron deficiency anemia 29.9 TNF EPO CRP
16 macrophage activation syndrome 29.9 TNFRSF1B TNF
17 lepromatous leprosy 29.9 TNF IL12RB1 IFNG
18 pulmonary sarcoidosis 29.8 TNF IL12RB1 IFNG
19 pulmonary tuberculosis 29.8 TNF IL12RB1 IFNG CRP ALB ADA
20 candidiasis 29.8 TNF IFNG CD40LG
21 pelvic inflammatory disease 29.8 IFNG CRP CD40LG
22 actinomycosis 29.8 CRP CD4 ALB
23 ileus 29.8 TNF IFNG CRP
24 human immunodeficiency virus type 1 29.8 TNF IFNG CD4 ADA
25 panniculitis 29.8 IFNG CSF3 CD8A
26 toxic shock syndrome 29.8 TNF IFNG CRP CD40LG
27 epidural abscess 29.7 CRP ALB
28 hydrocephalus 29.7 TNF IFNG EPO ENO2
29 tuberculous peritonitis 29.7 MUC16 IFNG CRP ALB ADA
30 spondylitis 29.7 TNFRSF1B TNF IFNG CRP
31 vaginal discharge 29.7 CRP CD40LG CD4
32 viral pneumonia 29.7 TNF CRP CD8A CD4
33 thymoma 29.7 TNF ENO2 CSF3 CD8A
34 deficiency anemia 29.7 TNF EPO CSF3 CRP ALB
35 enthesopathy 29.7 TNFRSF1B TNF CRP
36 listeria meningitis 29.7 TNF CD8A ADA
37 lymphadenitis 29.6 TNF PDCD1 IL12RB1 IFNG CRP CD4
38 pulmonary embolism 29.6 CRP CD40LG ALB
39 thrombocytopenia due to platelet alloimmunization 29.6 CD8A CD40LG CD4
40 conjunctivitis 29.6 TNF MUC16 IFNG
41 obstructive jaundice 29.6 TNF CRP ALB
42 lupus erythematosus 29.6 TNFRSF1B TNF PDCD1 IFNG CD40LG
43 pleural tuberculosis 29.6 TNF IFNG CD4 ADA
44 vasculitis 29.5 TNFRSF1B TNF CRP CD40LG
45 salpingitis 29.5 TNF CRP CD40LG
46 bronchiolitis obliterans 29.5 TNF IFNG CRP
47 laryngitis 29.5 TNF CRP CD40LG
48 multidrug-resistant tuberculosis 29.5 TNF IFNG CD4 ALB
49 pancytopenia 29.5 IFNG EPO CSF3 CRP CD8A CD40LG
50 pleurisy 29.5 TNF IFNG ENO2 CRP ADA

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ADA ALB CD4 CD40LG CD8A ENO2
2 hematopoietic system MP:0005397 10.21 ADA CD4 CD40LG CD8A CSF3 EPO
3 cardiovascular system MP:0005385 10.19 ADA ALB CD40LG CRP EPO IFNG
4 homeostasis/metabolism MP:0005376 10.18 ADA ALB CD4 CD40LG CRP EPO
5 immune system MP:0005387 10.18 ADA ALB CD4 CD40LG CD8A CRP
6 endocrine/exocrine gland MP:0005379 10.11 ADA ALB CD4 CD40LG CD8A IFNG
7 integument MP:0010771 10.02 CD4 CD40LG CD8A CSF3 EPO IFNG
8 liver/biliary system MP:0005370 9.8 ADA ALB EPO IFNG PDCD1 TNF
9 muscle MP:0005369 9.7 ADA ALB EPO IFNG PDCD1 TNF
10 renal/urinary system MP:0005367 9.56 ADA ALB CD40LG CD8A CSF3 IFNG
11 respiratory system MP:0005388 9.17 ADA ENO2 EPO IFNG PDCD1 TNF

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 3
2 Vaccines Phase 3
3 Immunologic Factors Phase 2
4 Adjuvants, Immunologic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DARDAR Health Project (Disseminated Tuberculosis and HIV Infection) Completed NCT00052195 Phase 2, Phase 3
2 A Randomised Controlled Trial in HIV-1 Exposed Ugandan Infants to Estimate Additional Benefits (Non-specific Effects) of BCG Recruiting NCT02606526 Phase 3
3 Double-blind (Observer-blind), Randomised, Controlled, Phase I/II Study, to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Candidate Tuberculosis Vaccine, Mtb72F/AS02A Administered Intramuscularly at 0, 1, 2 Months to Healthy PPD-positive Volunteers Aged 18 to 50 Years Completed NCT00146744 Phase 2
4 Phase II Randomised Controlled Trial to Evaluate Safety and Immunogenicity of MVA85A and Selective, Delayed Bacille Calmette-Guerin (BCG) Vaccination in Infants of HIV Infected Mothers Completed NCT01650389 Phase 2
5 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects in Cape Town, South Africa Unknown status NCT01693224
6 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects Unknown status NCT01525134
7 Glycosylated Ferritin in Differential Diagnosis of Still's Disease, Sepsis and Other Macrophagic Activation Syndromes. Recruiting NCT02143986

Search NIH Clinical Center for Miliary Tuberculosis

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

MalaCards organs/tissues related to Miliary Tuberculosis:

40
Lung, Liver, Bone, Bone Marrow, T Cells, Spleen, Heart

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 2006)
# Title Authors PMID Year
1
[Measurement of adenosine deaminase activity in bronchoalveolar lavage fluids as a tool for diagnosing miliary tuberculosis]. 54 61
8622268 1996
2
Abdominal Tuberculosis Mimicking Cancer Clinically and on Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET) Imaging: A Two-Case Series. 61
32019906 2020
3
Repeated Chest Computed Tomography Revealed Early-stage Miliary Tuberculosis. 61
31588079 2020
4
[Tuberculosis and immune reconstitution inflammatory syndrome. Pediatric case]. 61
31984707 2020
5
Mycobacterium tuberculosis infection in psoriatic patients treated with biologics: Real-world data from 18 Japanese facilities. 61
31763718 2020
6
Miliary tuberculosis and choroidal tuberculoma in a three-month old baby girl: Diagnosis and follow-up of a case. 61
31771808 2020
7
Ground-glass opacity as a paradoxical reaction in miliary tuberculosis: A case report and review of the literature. 61
31908948 2020
8
Miliary tuberculosis leading to acute respiratory distress syndrome: Clinical experience in pediatric intensive care. 61
31496114 2019
9
Pulmonary alveolar microlithiasis and interstitial pneumonitis: a case report of the west of Iran. 61
31724942 2019
10
Multiple Cranial Tuberculomas Without Meningitis in Two Infants With Miliary Tuberculosis. 61
31738344 2019
11
Severe rifampicin-induced thrombocytopenia in a patient with miliary tuberculosis. 61
31722846 2019
12
Tuberculous Bronchoesophageal Fistula in Nephrotic Syndrome: A Silent Assassin. 61
31741942 2019
13
Miliary tuberculosis with delayed-onset total knee arthroplasty Mycobacteria tuberculosis infection successfully treated with medical therapy alone: A case report and literature review. 61
31427242 2019
14
A rare case of miliary tuberculosis accompanying perihepatitis. 61
30743325 2019
15
Congenital tuberculosis in an extremely preterm infant and prevention of nosocomial infection. 61
30910506 2019
16
A Treatment-Decision Score for HIV-Infected Children With Suspected Tuberculosis. 61
31455612 2019
17
Discrete cutaneous lesions in a critically ill patient treated only for AIDS and miliary tuberculosis: a case report of disseminated histoplasmosis. 61
31553862 2019
18
Miliary tuberculosis and acute respiratory distress syndrome. 61
31720435 2019
19
Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. 61
31382453 2019
20
Pediatric miliary tuberculosis presenting with stroke: contribution to the paper "Tuberculosis of the central nervous system in children". 61
31256240 2019
21
Miliary tuberculosis induced by intravesical instillation of bacillus Calmette-Guérin. 61
30898332 2019
22
Papillitis and neuroretinitis of tuberculous etiology. 61
30718012 2019
23
Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study. 61
30659816 2019
24
[Disseminated tuberculosis revealed by obstructive and prerenal acute kidney failure]. 61
31097378 2019
25
A Rare Manifestation of Tuberculosis in a Renal Transplant Patient: A Case Report. 61
31155204 2019
26
Diagnostic utility of PET/CT in a patient with miliary tuberculosis. 61
31181879 2019
27
A 'cold case' of care: Looking at old data from a new perspective in mummy research. 61
30120031 2019
28
[Surgical treatment of a ruptured aneurysm of the left common iliac artery in a patient with miliary tuberculosis]. 61
31029278 2019
29
A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer. 61
31067427 2019
30
Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report. 61
31027078 2019
31
Melioidosis mimicking miliary tuberculosis. 61
30293222 2019
32
An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions. 61
30244358 2019
33
Chronic cutaneous miliary tuberculosis - a forgotten entity. 61
30387135 2019
34
Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study. 61
30554051 2019
35
Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer. 61
30621812 2019
36
An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Toward the Female Sex Is Associated With Advanced Acquired Immune Deficiency Syndrome. 61
31355171 2019
37
Atypical Radiographic Presentation of Cryptococcus Pneumonia in a Newly Diagnosed HIV Patient. 61
31032130 2019
38
[Miliary tuberculosis with markedly elevated soluble interleukin-2 receptor levels mimicking intravascular large B-cell lymphoma]. 61
31068516 2019
39
Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome. 61
31275676 2019
40
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis. 61
30863732 2019
41
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 61
31384143 2019
42
Tuberculous cellulitis in an immunocompetent patient. 61
30956584 2019
43
Pulmonary Sarcoidosis Presenting with Miliary Opacities. 61
31964332 2019
44
Miliary tuberculosis presenting as bilateral superficial femoral artery mycotic aneurysm in an immunocompetent patient. 61
30775239 2019
45
ARDS from miliary tuberculosis successfully treated with ECMO. 61
30662828 2019
46
Immunological Impacts of Diabetes on the Susceptibility of Mycobacterium tuberculosis. 61
31583258 2019
47
Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. 61
31156614 2019
48
A challenging case of pelvic inflammatory disease due to miliary tuberculosis. 61
30117595 2018
49
Miliary tuberculosis developing during adalimumab treatment for Behçet's disease with uveitis. 61
30567192 2018
50
Miliary Tuberculosis in a Crohn's Disease Patient: The Risk beyond the Screening. 61
30675506 2018

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 TNFRSF1B TNF PDCD1 MUC16 IL12RB1 IFNG
2
Show member pathways
13.58 TNFRSF1B TNF IL12RB1 IFNG EPO CSF3
3
Show member pathways
13.25 TNFRSF1B TNF IL12RB1 IFNG CSF3 CD40LG
4
Show member pathways
12.76 TNF IFNG CD8A CD40LG CD4
5
Show member pathways
12.54 TNFRSF1B TNF IFNG CD40LG CD4
6
Show member pathways
12.49 TNFRSF1B TNF IL12RB1 IFNG CD40LG CD4
7
Show member pathways
12.45 TNF PDCD1 IFNG CD8A CD40LG CD4
8 12.4 TNFRSF1B TNF PDCD1 IFNG CD8A CD40LG
9
Show member pathways
12.25 TNF IFNG CRP ALB
10
Show member pathways
12.23 IL12RB1 IFNG EPO CSF3
11 12 PDCD1 CD8A CD40LG CD4
12
Show member pathways
11.93 TNF IL12RB1 IFNG CD4
13
Show member pathways
11.85 IL12RB1 IFNG CD8A CD4
14
Show member pathways
11.69 TNF IFNG CD40LG
15
Show member pathways
11.67 TNFRSF1B TNF CD40LG
16 11.65 TNF IFNG CD8A CD4
17 11.65 TNF EPO CSF3 CD8A CD4
18
Show member pathways
11.59 TNF IFNG CD40LG
19
Show member pathways
11.57 TNF IFNG CD8A
20 11.49 PDCD1 CD40LG CD4
21
Show member pathways
11.46 TNFRSF1B TNF IFNG
22 11.44 TNFRSF1B TNF CSF3
23 11.37 TNF IFNG CSF3 CD40LG
24 11.26 TNF IL12RB1 IFNG CD8A CD4
25 11.22 TNFRSF1B IFNG CD40LG
26 11.2 CD8A CD40LG CD4 ADA
27 11.16 TNF IFNG EPO CSF3 CD8A CD4
28 10.92 TNF IFNG CSF3 CD4

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10 TNFRSF1B TNF PDE6B PDCD1 MUC16 IL12RB1
2 extracellular region GO:0005576 9.85 TNFRSF1B TNF MUC16 IFNG EPO CSF3
3 cell surface GO:0009986 9.72 TNF EPO CD40LG CD4 ADA
4 extracellular space GO:0005615 9.65 TNF MUC16 IFNG EPO ENO2 CSF3
5 external side of plasma membrane GO:0009897 9.17 TNF PDCD1 IL12RB1 CD8A CD40LG CD4

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 PDCD1 EPO CD40LG ALB ADA
2 cell surface receptor signaling pathway GO:0007166 9.83 TNFRSF1B IFNG CD8A CD4
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 TNF EPO CSF3
4 cytokine-mediated signaling pathway GO:0019221 9.72 TNFRSF1B TNF IL12RB1 CSF3 CD4
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IFNG EPO
6 negative regulation of neuron death GO:1901215 9.69 TNFRSF1B EPO CSF3
7 positive regulation of protein kinase activity GO:0045860 9.67 TNF EPO CD4
8 humoral immune response GO:0006959 9.65 TNF PDCD1 IFNG
9 T cell activation GO:0042110 9.61 CD8A CD4 ADA
10 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IFNG
11 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
12 extrinsic apoptotic signaling pathway GO:0097191 9.58 TNFRSF1B TNF IFNG
13 response to salt stress GO:0009651 9.57 TNF EPO
14 negative regulation of lipid storage GO:0010888 9.55 TNF CRP
15 regulation of immunoglobulin secretion GO:0051023 9.46 TNF CD40LG
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 TNF IFNG
17 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 TNF IFNG
18 immune response GO:0006955 9.17 TNFRSF1B TNF IFNG CSF3 CD8A CD40LG
19 positive regulation of nitrogen compound metabolic process GO:0051173 9.16 TNF IFNG
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 TNFRSF1B TNF IFNG

Molecular functions related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 TNFRSF1B TNF PDE6B PDCD1 MUC16 IL12RB1
2 cytokine activity GO:0005125 9.02 TNF IFNG EPO CSF3 CD40LG

Sources for Miliary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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