MCID: MLR002
MIFTS: 47

Miliary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Miliary Tuberculosis

MalaCards integrated aliases for Miliary Tuberculosis:

Name: Miliary Tuberculosis 12 15 17 33
Acute Miliary Tuberculosis 12 72
Tuberculosis, Miliary 44 72
Tuberculosis Miliaris Disseminata 12
Disseminated Tuberculosis 12
Tuberculosis Disseminated 55
Generalized Tuberculosis 12
Tuberculosis Miliary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9861
ICD9CM 35 018 018.9 018.90
MeSH 44 D014391
NCIt 50 C35086
SNOMED-CT 68 47604008
ICD10 33 A19 A19.2 A19.9
UMLS 72 C0041321 C0152915

Summaries for Miliary Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs.

MalaCards based summary : Miliary Tuberculosis, also known as acute miliary tuberculosis, is related to tuberculous meningitis and meningitis. An important gene associated with Miliary Tuberculosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Immune response NFAT in immune response and Th17 cell differentiation. The drugs BCG vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and spleen, and related phenotypes are cellular and hematopoietic system

Wikipedia : 75 Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the... more...

Related Diseases for Miliary Tuberculosis

Diseases related to Miliary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 505)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 31.1 ENO2 ADA
2 meningitis 30.9 IFNG ADA
3 mycobacterium tuberculosis 1 30.7 IL12RB1 IFNG ADA
4 peritonitis 30.5 MUC16 ADA
5 lymphadenitis 30.2 IL12RB1 IFNG
6 pulmonary tuberculosis 30.0 IL12RB1 IFNG ADA
7 pericarditis 29.9 IFNG ADA
8 acquired immunodeficiency syndrome 29.9 IFNG EPO CD4
9 extrapulmonary tuberculosis 29.8 IFNG ADA
10 lepromatous leprosy 29.8 IL12RB1 IFNG
11 conjunctivitis 29.7 MUC16 IFNG
12 pericardial effusion 29.7 MUC16 ADA
13 abdominal tuberculosis 29.5 IL12RB1 ADA
14 tuberculous peritonitis 29.5 MUC16 IFNG ADA
15 pleural tuberculosis 29.4 IFNG ADA
16 cryptococcal meningitis 29.2 IFNG ADA
17 hypersplenism 29.1 IFNG EPO CD4
18 hemophagocytic lymphohistiocytosis 29.0 IFNG ENO2 ADA
19 human immunodeficiency virus type 1 29.0 IFNG CD4 ADA
20 pleurisy 28.7 MUC16 IFNG ENO2 ADA
21 respiratory failure 10.6
22 adult respiratory distress syndrome 10.6
23 pancytopenia 10.6
24 acute respiratory distress syndrome 10.6
25 pneumothorax 10.5
26 disseminated intravascular coagulation 10.5
27 lupus erythematosus 10.4
28 lymphopenia 10.4
29 thrombocytopenia 10.3
30 pericardial mesothelioma 10.3 MUC16 ENO2
31 brain injury 10.3 EPO ENO2
32 meningeal melanomatosis 10.3 PDCD1 ENO2
33 lymphoepithelioma-like carcinoma 10.3 PDCD1 ENO2
34 systemic lupus erythematosus 10.3
35 crohn's disease 10.3
36 splenomegaly 10.3
37 pneumothorax, primary spontaneous 10.3
38 purpura 10.3
39 central nervous system melanocytic neoplasm 10.3 PDCD1 ENO2
40 sarcoidosis 1 10.3
41 toxic shock syndrome 10.3
42 atopic keratoconjunctivitis 10.2 MUC16 IFNG
43 hemangioblastoma 10.2 EPO ENO2
44 immune deficiency disease 10.2
45 deficiency anemia 10.2
46 lymphoma 10.2
47 neutropenia 10.2
48 leukemia 10.2
49 pneumonia 10.2
50 alcohol dependence 10.2

Comorbidity relations with Miliary Tuberculosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Miliary Tuberculosis:



Diseases related to Miliary Tuberculosis

Symptoms & Phenotypes for Miliary Tuberculosis

MGI Mouse Phenotypes related to Miliary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 ADA CD4 ENO2 EPO IFNG PDCD1
2 hematopoietic system MP:0005397 9.63 ADA CD4 EPO IFNG IL12RB1 PDCD1
3 immune system MP:0005387 9.43 ADA CD4 EPO IFNG IL12RB1 PDCD1
4 respiratory system MP:0005388 9.02 ADA ENO2 EPO IFNG PDCD1

Drugs & Therapeutics for Miliary Tuberculosis

Drugs for Miliary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 3
2 Vaccines Phase 3
3 Adjuvants, Immunologic Phase 2
4 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DARDAR Health Project (Disseminated Tuberculosis and HIV Infection) Completed NCT00052195 Phase 2, Phase 3
2 A Randomised Controlled Trial in HIV-1 Exposed Ugandan Infants to Estimate Additional Benefits (Non-specific Effects) of BCG Recruiting NCT02606526 Phase 3
3 Double-blind (Observer-blind), Randomised, Controlled, Phase I/II Study, to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Candidate Tuberculosis Vaccine, Mtb72F/AS02A Administered Intramuscularly at 0, 1, 2 Months to Healthy PPD-positive Volunteers Aged 18 to 50 Years Completed NCT00146744 Phase 2
4 Phase II Randomised Controlled Trial to Evaluate Safety and Immunogenicity of MVA85A and Selective, Delayed Bacille Calmette-Guerin (BCG) Vaccination in Infants of HIV Infected Mothers Completed NCT01650389 Phase 2
5 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects Unknown status NCT01525134
6 Feasibility of Using the Inverness Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in HIV-Positive TB Suspects in Cape Town, South Africa Unknown status NCT01693224
7 Glycosylated Ferritin in Differential Diagnosis of Still's Disease, Sepsis and Other Macrophagic Activation Syndromes. Recruiting NCT02143986

Search NIH Clinical Center for Miliary Tuberculosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Prednisone
Rifampicin

Cochrane evidence based reviews: tuberculosis, miliary

Genetic Tests for Miliary Tuberculosis

Anatomical Context for Miliary Tuberculosis

MalaCards organs/tissues related to Miliary Tuberculosis:

41
Lung, Liver, Spleen, Bone, Bone Marrow, Brain, Testes

Publications for Miliary Tuberculosis

Articles related to Miliary Tuberculosis:

(show top 50) (show all 1987)
# Title Authors PMID Year
1
[Measurement of adenosine deaminase activity in bronchoalveolar lavage fluids as a tool for diagnosing miliary tuberculosis]. 9 38
8622268 1996
2
Congenital tuberculosis in an extremely preterm infant and prevention of nosocomial infection. 38
30910506 2019
3
Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. 38
31382453 2019
4
Pediatric miliary tuberculosis presenting with stroke: contribution to the paper "Tuberculosis of the central nervous system in children". 38
31256240 2019
5
Miliary tuberculosis with delayed-onset total knee arthroplasty Mycobacteria tuberculosis infection successfully treated with medical therapy alone: A case report and literature review. 38
31427242 2019
6
Miliary tuberculosis induced by intravesical instillation of bacillus Calmette-Guérin. 38
30898332 2019
7
Papillitis and neuroretinitis of tuberculous etiology. 38
30718012 2019
8
Diagnostic utility of PET/CT in a patient with miliary tuberculosis. 38
31181879 2019
9
A 'cold case' of care: Looking at old data from a new perspective in mummy research. 38
30120031 2019
10
Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study. 38
30659816 2019
11
A Rare Manifestation of Tuberculosis in a Renal Transplant Patient: A Case Report. 38
31155204 2019
12
[Disseminated tuberculosis revealed by obstructive and prerenal acute kidney failure]. 38
31097378 2019
13
[Surgical treatment of a ruptured aneurysm of the left common iliac artery in a patient with miliary tuberculosis]. 38
31029278 2019
14
A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer. 38
31067427 2019
15
Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report. 38
31027078 2019
16
Melioidosis mimicking miliary tuberculosis. 38
30293222 2019
17
Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer. 38
30621812 2019
18
An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions. 38
30244358 2019
19
Chronic cutaneous miliary tuberculosis - a forgotten entity. 38
30387135 2019
20
A rare case of miliary tuberculosis accompanying perihepatitis. 38
30743325 2019
21
Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study. 38
30554051 2019
22
ARDS from miliary tuberculosis successfully treated with ECMO. 38
30662828 2019
23
Miliary tuberculosis presenting as bilateral superficial femoral artery mycotic aneurysm in an immunocompetent patient. 38
30775239 2019
24
Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. 38
31156614 2019
25
An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Toward the Female Sex Is Associated With Advanced Acquired Immune Deficiency Syndrome. 38
31355171 2019
26
Atypical Radiographic Presentation of Cryptococcus Pneumonia in a Newly Diagnosed HIV Patient. 38
31032130 2019
27
[Miliary tuberculosis with markedly elevated soluble interleukin-2 receptor levels mimicking intravascular large B-cell lymphoma]. 38
31068516 2019
28
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis. 38
30863732 2019
29
Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome. 38
31275676 2019
30
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 38
31384143 2019
31
Tuberculous cellulitis in an immunocompetent patient. 38
30956584 2019
32
Contribution of brain imaging to the diagnosis of intracranial tuberculoma and other brain lesions in patients presenting with miliary tuberculosis. 38
30017477 2018
33
A challenging case of pelvic inflammatory disease due to miliary tuberculosis. 38
30117595 2018
34
Miliary tuberculosis developing during adalimumab treatment for Behçet's disease with uveitis. 38
30567192 2018
35
Miliary Tuberculosis in a Crohn's Disease Patient: The Risk beyond the Screening. 38
30675506 2018
36
An Infant with Xpert® Confirmed TB Meningitis in Central Viet Nam. 38
30380608 2018
37
[Septic shock in a female patient with miliary tuberculosis]. 38
30259054 2018
38
Miliary tuberculosis and herpes pharyngitis after a trip to a developing country: dangers of biologics. 38
30279249 2018
39
Granulomatous Hepatitis with Miliary Mottling: A Rare Cause. 38
31321943 2018
40
Relationship between malaria epidemiology and the human development index in Colombia and Latin America. 38
30246769 2018
41
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. 38
30246772 2018
42
Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female. 38
30189694 2018
43
[Pulmonary intravascular talcosis: A case report]. 38
29650301 2018
44
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. 38
29890558 2018
45
Surprising pathological and clinical manifestations of miliary tuberculosis. 38
29754134 2018
46
Comparison of clinical manifestations and treatment outcome according to age groups in adult patients with miliary tuberculosis. 38
29997953 2018
47
Miliary tuberculosis during adalimumab therapy in Crohn's disease. 38
28743405 2018
48
Use of rifabutin to treat tuberculosis in a cardiac transplant recipient: A case report
. 38
29350178 2018
49
Does pyuria always suggest urinary tract infection with common microorganisms? Questions. 38
28721513 2018
50
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. 38
29719654 2018

Variations for Miliary Tuberculosis

Expression for Miliary Tuberculosis

Search GEO for disease gene expression data for Miliary Tuberculosis.

Pathways for Miliary Tuberculosis

Pathways related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 IL12RB1 IFNG CD4
2
Show member pathways
12.27 IL12RB1 IFNG CD4
3
Show member pathways
12.26 IL12RB1 IFNG CD4
4
Show member pathways
12.19 PDCD1 IFNG CD4
5
Show member pathways
12.05 IL12RB1 IFNG EPO
6
Show member pathways
11.66 IL12RB1 IFNG CD4
7 11.5 IFNG EPO CD4
8 11.48 CD4 ADA
9 11.45 IFNG CD4
10 11.44 IL12RB1 IFNG EPO
11
Show member pathways
11.38 IL12RB1 IFNG CD4
12 11.26 PDCD1 CD4
13 11.19 IFNG CD4
14 11.17 IFNG EPO ENO2
15 11.06 CD4 ADA
16
Show member pathways
10.92 IL12RB1 IFNG
17 10.9 IFNG CD4
18 10.85 IFNG CD4
19 10.7 IL12RB1 IFNG CD4

GO Terms for Miliary Tuberculosis

Cellular components related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 MUC16 IFNG EPO ENO2 ADA
2 external side of plasma membrane GO:0009897 8.92 PDCD1 IL12RB1 CD4 ADA

Biological processes related to Miliary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 IFNG EPO
2 positive regulation of protein kinase activity GO:0045860 9.4 EPO CD4
3 humoral immune response GO:0006959 9.37 PDCD1 IFNG
4 T cell activation GO:0042110 9.32 CD4 ADA
5 interleukin-12-mediated signaling pathway GO:0035722 9.26 IL12RB1 IFNG
6 positive regulation of activated T cell proliferation GO:0042104 9.16 IL12RB1 EPO
7 positive regulation of T cell activation GO:0050870 8.96 CD4 ADA
8 positive regulation of calcium-mediated signaling GO:0050850 8.62 CD4 ADA

Sources for Miliary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....