MCID: MLK006
MIFTS: 45

Milk Allergy

Categories: Gastrointestinal diseases, Immune diseases
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Aliases & Classifications for Milk Allergy

MalaCards integrated aliases for Milk Allergy:

Name: Milk Allergy 11 14 75
Milk Allergic Reaction 11 16
Milk Hypersensitivity 43 71
Allergy Milk 53

Classifications:



External Ids:

Disease Ontology 11 DOID:4376
MeSH 43 D016269
UMLS 71 C0079840

Summaries for Milk Allergy

Disease Ontology: 11 A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

MalaCards based summary: Milk Allergy, also known as milk allergic reaction, is related to goat milk allergy and lactose intolerance. An important gene associated with Milk Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Soy Bean and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and t cells, and related phenotypes are endocrine/exocrine gland and no phenotypic analysis

Wikipedia: 75 Milk allergy is an adverse immune reaction to one or more proteins in cow's milk. Among the possible... more...

Related Diseases for Milk Allergy

Diseases related to Milk Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)
# Related Disease Score Top Affiliating Genes
1 goat milk allergy 32.6 TSLP CSN2 CSN1S1
2 lactose intolerance 31.8 LALBA IL10 CSN2 CSN1S1
3 chronic rhinitis 30.6 RNASE3 PEDS1 IL5 IL4 IL13
4 eosinophilic gastroenteritis 30.5 RNASE3 IL5 IL4 IL13 IGHE
5 cholera 30.4 IL5 IL4 IL10 CD79A
6 cow milk allergy 30.3 PEDS1 LALBA IL5 IL4 IL13 IL10
7 gastroenteritis 30.3 RNASE3 IL5 IL4 IL10
8 diarrhea 30.1 IL5 IL13 IL10 FOXP3
9 enterobiasis 30.1 IL5 IL4
10 ige responsiveness, atopic 30.1 RNASE3 IL5 IL4 IL13 IL10 IGHE
11 chronic urticaria 30.0 RNASE3 IL5 IGHE
12 wheat allergy 29.9 PEDS1 IGHE
13 rubella 29.8 IL5 IL4 IL10
14 esophagitis, eosinophilic, 1 29.8 TSLP RNASE3 IL5 IL4 IL13 CCR6
15 neurodermatitis 29.8 TSLP IL4 IL13
16 eosinophilic gastritis 29.8 TSLP IL5 IL13
17 exanthem 29.8 IL4 IL10 CD4 CCR6
18 diphtheria 29.7 IL5 IL4 IL13
19 severe combined immunodeficiency, x-linked 29.7 TSLP IL4 IL13
20 esophagitis 29.7 TSLP RNASE3 IL5 IL4 IL13 IL10
21 hypereosinophilic syndrome 29.7 RNASE3 IL5 IL4 IL13 IL10 IGHE
22 allergic rhinitis 29.6 RNASE3 IL5 IL4 IL13 IL10 IGHE
23 giardiasis 29.6 IL10 CD79A CD4
24 extrinsic allergic alveolitis 29.6 TGFB2 IGHE CD4 CCR6
25 tetanus 29.5 IL5 IL4 IL13 IL10 CD79A
26 pneumonia 29.5 IL5 IL4 IL13 IL10
27 otitis media 29.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
28 urticaria 29.4 TSLP RNASE3 IL5 IL4 IL13 IL10
29 rhinitis 29.4 TSLP RNASE3 IL5 IL4 IL13 IL10
30 perinatal necrotizing enterocolitis 29.4 LALBA IL10 CSN1S1 CD4 CCR6
31 miliary tuberculosis 29.3 IL4 IL10 CD4
32 immunoglobulin alpha deficiency 29.3 IL10 CD79A CD4 CCR6
33 intestinal perforation 29.2 IL10 CD4 CCR6
34 aphthous stomatitis 29.2 IL10 CD4 CCR6
35 dysentery 29.2 IL10 CD4 CCR6
36 dermatitis 29.2 TSLP RNASE3 IL5 IL4 IL13 IL10
37 proteasome-associated autoinflammatory syndrome 1 29.2 RNASE3 IL5 IL4 IL13 IL10 IGHE
38 bronchitis 29.2 RNASE3 IL5 IL4 IL13 IL10 IGHE
39 nephrotic syndrome 29.1 IL4 IL13 IGES CD79A CD4
40 type 1 diabetes mellitus 28.9 IL4 IL10 FOXP3 CSN2 CD79A CCR6
41 inflammatory bowel disease 28.8 RNASE3 IL5 IL4 IL13 IL10 FOXP3
42 conjunctivitis 28.8 RNASE3 IL5 IL4 IL13 IL10 IGHE
43 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 28.7 IL4 IL10 FOXP3 CD4 CCR6
44 allergic asthma 28.6 TSLP RNASE3 IL5 IL4 IL13 IL10
45 colitis 28.6 IL5 IL4 IL13 IL10 FOXP3 CD4
46 hyper ige syndrome 28.5 RNASE3 IL4 IL10 IGHE IGES CD4
47 occupational asthma 28.5 TSLP RNASE3 PEDS1 IL5 IL4 IL13
48 allergic disease 28.5 TSLP RNASE3 LALBA IL5 IL4 IL13
49 food allergy 28.3 TSLP RNASE3 PEDS1 LALBA IL5 IL4
50 immune deficiency disease 28.2 IL4 IL13 IL10 FOXP3 CD79A CD69

Graphical network of the top 20 diseases related to Milk Allergy:



Diseases related to Milk Allergy

Symptoms & Phenotypes for Milk Allergy

MGI Mouse Phenotypes related to Milk Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.06 CD4 CSN1S1 CSN2 CSN3 EHF FOXP3
2 no phenotypic analysis MP:0003012 9.97 CD4 CD69 CD79A FOXP3 IGHE IL10
3 immune system MP:0005387 9.93 CCR6 CD4 CD69 CD79A FOXP3 IGHE
4 digestive/alimentary MP:0005381 9.91 CD4 EHF FOXP3 IL10 IL13 IL4
5 hematopoietic system MP:0005397 9.77 CCR6 CD4 CD69 CD79A FOXP3 IGHE
6 integument MP:0010771 9.32 CD4 CSN1S1 CSN2 CSN3 FOXP3 IL10

Drugs & Therapeutics for Milk Allergy

Drugs for Milk Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Soy Bean Phase 4
2
Omalizumab Approved, Investigational Phase 2 242138-07-4
3 Immunoglobulins, Intravenous Phase 1, Phase 2
4 Immunoglobulins Phase 2
5 Immunoglobulin E Phase 1, Phase 2
6 Antibodies Phase 2
7 Immunologic Factors Phase 2
8 Anti-Asthmatic Agents Phase 2
9 Anti-Allergic Agents Phase 2
10 Respiratory System Agents Phase 2
11 Antibodies, Monoclonal Phase 2
12 Vaccines Phase 2
13 Cassava Phase 2
14 Caseins Phase 2
15 Acidophilus Phase 2
16 Chelating Agents Phase 2
17
Calcium carbonate Approved, Investigational 471-34-1
18
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
19
Tannic acid Approved 1401-55-4 16129878 16129778
20 Calcium, Dietary
21 Dermatologic Agents
22 Complement System Proteins
23 Whey Protein
24
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 105)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study: Milk Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
2 Parmigiano-Reggiano Cheese as a Possible Strategy of Immunonutrition Able to Stimulate the Acquisition of Oral Tolerance in Childre With Cow's Milk Allergy Unknown status NCT02081651 Phase 3
3 Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy Completed NCT02351531 Phase 3
4 Evaluation of the Hypoallergenicity of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow's Milk Protein Allergy Completed NCT02711163 Phase 3
5 Cow's Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula (TeHF2013-01) in Infants With Confirmed Cow's Milk Protein Allergy Unknown status NCT02149134 Phase 2
6 EPIGENETIC EFFECTS ELICITED BY LACTOBACILLUS GG IN CHILDREN WITH COW'S MILK ALLERGY: A POSSIBLE EFFECT OF ATOPIC MARCH Unknown status NCT02062476 Phase 2
7 Efficacy of Baked Milk in Accelerating Resolution of Cow's Milk Allergy Completed NCT02738060 Phase 2
8 A Double, Blind Placebo-controlled, Randomized Trial to Study Efficacy and Safety of the Viaskin Milk for Treating Milk Induced Eosinophilic Esophagitis in Children Completed NCT02579876 Phase 2 Viaskin Milk 500 mcg;Viaskin Placebo
9 The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy Completed NCT00732654 Phase 1, Phase 2 Milk Protein Extract Immunotherapy goal of 4mg/day;Milk Protein Extract Immunotherapy goal of 7mg/day;Milk Powder Immunotherapy goal dose 2000 mg/day;Milk Powder Immunotherapy goal dose 1000mg/day
10 The Effectiveness of Milk Allergy Elimination Through NAET Treatments Completed NCT00328731 Phase 1, Phase 2
11 Tolerability to a New Free Amino Acid-based Formula in Children With Cow's Milk Protein Allergy Completed NCT02536482 Phase 2
12 Oral Immunotherapy Combined With Humanized Monoclonal Anti-IgE Antibody Xolair® (Omalizumab)in the Treatment of Cow's Milk Allergy Completed NCT01157117 Phase 2 Milk powder
13 Dietary Intervention in Milk Allergy and Tolerance Development Completed NCT00778258 Phase 2
14 A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy Completed NCT00465569 Phase 1, Phase 2 cow's milk powder
15 A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow's Milk Allergy in Children Completed NCT02223182 Phase 1, Phase 2
16 A Phase 2 Study to Evaluate the Sensitivity, Specificity and Safety of DBV1605, a Ready-to-Use Atopy Patch Test for the Diagnosis of Non-Immunoglobulin E Mediated Cow's Milk Allergy in Children Recruiting NCT04492683 Phase 2
17 A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab and Milk Oral Immunotherapy for the Treatment of Patients With Cow's Milk Allergy Recruiting NCT04148352 Phase 2 Dupilumab
18 Phase II Study of Baked Milk Oral Immunotherapy for the Treatment of Cow's Milk Allergy Active, not recruiting NCT03462030 Phase 2 Baked non-fat cow's milk powder;Placebo: Tapioca Powder
19 A Prospective Randomized Controlled Trial to Evaluate the Effect of Infant Formula on the Resolution of Cow's Milk Allergy of Infancy Terminated NCT02719405 Phase 2
20 Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients Unknown status NCT01968278
21 the Value of Serum Esnophilic Cationic Protein as a Diagnostic Parameter in Infants With Cow Milk Protein Allergy Unknown status NCT04684329
22 DETERMINATION OF HYPOALLERGENICITY TO SUBSTITUTIVE FORMULAS IN CHILDREN WITH COW'S MILK ALLERGY Unknown status NCT02144428
23 Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy Unknown status NCT02087930
24 Epigenetic Effects Involved in Children With Cow's Milk Allergy: A Possible Effect of Hypoallergenic Formulas Unknown status NCT04184700
25 The Effect of Early Childhood Cow's Milk Allergy Elimination Diet on Eating Behaviors, Nutrition, and Growth Status at Age 2-6 Unknown status NCT04576845
26 Preventive Effect of Lactobacillus GG on Atopic Manifestation in Children With Cow's Milk Allergy Unknown status NCT01891916
27 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
28 Mineral Status in Infants With Cow's Milk Protein Allergy Before and After Receiving Amino Acid-based Formula (AAF) Unknown status NCT04327297
29 Basophil Activation Test to Diagnose Food Allergy Unknown status NCT03309488
30 Comiss Score Fore Detection of Cow's Milk Protein Allergy Unknown status NCT03664076
31 Assessment of Cow's Milk-related Symptom Scoring Awareness Tool in Young Turkish Children Unknown status NCT03223181
32 Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora Unknown status NCT00298376
33 Efficacy of the "Milk Ladder" Intervention in the Development of Tolerance and the Recognition of B Cell Epitopes in Babies Who Are Allergic to Cow's Milk Proteins Unknown status NCT03466931
34 Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University Unknown status NCT03456479
35 Young Adults With Life Threatening Cow's Milk Allergy: Risks of Decrease Bone Mineralization and Methods of Calcium Supplementation Unknown status NCT01930266
36 Cow's Milk Allergy in Infants With Obstructive Sleep Apnea Unknown status NCT00659854
37 Tolerability of the New Hypoallergenic Formula in Children With IgE Mediated Cow's Milk Allergy Unknown status NCT03909113
38 Dietary Choice for the Management of Cow's Milk Allergy Influences the Acquisition of Oral Tolerance and the Occurrence of Other Allergic Manifestations Unknown status NCT03861910
39 The Evaluation of the Effects of an Extensive Casein Hydrolysate Containing the Probiotic Lactobacillus Rhamnosus GG as a Possible Step Down Approach Able to Stimulate the Acquisition of Immunological Tolerance Compared to an Amino Acid Formula in Children Affected by Cow's Milk Protein Allergy Unknown status NCT03449537
40 The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy Completed NCT01950533
41 Clinical and Biological Description of an Atypical IgE-mediated Cow Milk Allergy (CMA) Form With Hands and Feet Angio-oedema From the Diagnosis to Its Spontaneous Evolution and Comparison to the Typical CMA Form Without Oedema of Extremities Completed NCT04318483
42 A Double-blind Randomized Controlled Trial of a Thickened Amino-acid-based Formula in Children Allergic to Cow's Milk and to Protein Hydrolysates Completed NCT01940068
43 A Prospective, Randomized, DB Controlled Study to Evaluate the Nutritional Safety (Growth) of an Amino Acid Based Formula With Prebiotics and Probiotics in Infants Diagnosed With Cow Milk Allergy, With or Without Other Food Allergies. Completed NCT00664768
44 Effect of Lactobacillus GG on the Appearance of Functional Gastrointestinal Disorders in Children With Cow's Milk Allergy Completed NCT01901380
45 Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assiut University Children Hospital Completed NCT04330092
46 Symptoms Based Awareness Confirmation Study - CoMiSS Validation Completed NCT03004729
47 Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy Completed NCT02779881
48 Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy Completed NCT01622426
49 A Multicenter, Randomized, Controlled, Cross-over Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy Completed NCT02414243
50 Epigenetic Effects Involved in Children With Cow's Milk Allergy: A Possible Effect of Atopic March of Lactobacillus GG (EPICMA) Completed NCT02466035

Search NIH Clinical Center for Milk Allergy

Cochrane evidence based reviews: milk hypersensitivity

Genetic Tests for Milk Allergy

Anatomical Context for Milk Allergy

Organs/tissues related to Milk Allergy:

MalaCards : Small Intestine, Colon, T Cells, Bone, Skin, Breast, B Cells

Publications for Milk Allergy

Articles related to Milk Allergy:

(show top 50) (show all 1836)
# Title Authors PMID Year
1
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. 53 62
20462631 2010
2
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. 53 62
20226304 2010
3
[Sensitization to casein and beta-lactoglobulin (BLG) in children with cow's milk allergy (CMA)]. 53 62
20212353 2010
4
Peptides surviving the simulated gastrointestinal digestion of milk proteins: biological and toxicological implications. 53 62
19962948 2010
5
Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis. 53 62
20079488 2010
6
Effects of heating and glycation of beta-lactoglobulin on its recognition by IgE of sera from cow milk allergy patients. 53 62
19489627 2009
7
Eliciting doses of positive challenge test in cow's milk allergy are related to cow's milk specific IgE levels. 53 62
19150029 2008
8
Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. 53 62
18384430 2008
9
Usefulness of specific IgE levels in predicting cow's milk allergy. 53 62
18155280 2008
10
The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. 53 62
17651374 2007
11
Sensitization to serum albumins in children allergic to cow's milk and epithelia. 53 62
17680908 2007
12
Maintenance of tolerance to cow's milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. 53 62
17581206 2007
13
Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. 53 62
17573720 2007
14
Casein-specific immunoglobulins in cow's milk allergic patient subgroups reveal a shift to IgA dominance in tolerant patients. 53 62
17295802 2007
15
Memory T cell proliferation in cow's milk allergy after CD25+ regulatory T cell removal suggests a role for casein-specific cellular immunity in IgE-mediated but not in non-IgE-mediated cow's milk allergy. 53 62
17106206 2007
16
Effect of extensively hydrolyzed milk formula on growth and resistance to bronchitis and atopic dermatitis in infants and toddlers. 53 62
16784012 2006
17
IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients. 53 62
17039668 2006
18
Z-score of weight for age of infants with atopic dermatitis and cow's milk allergy fed with a rice-hydrolysate formula during the first two years of life. 53 62
16214777 2005
19
Human IgE binding to the glycosidic moiety of bovine kappa-casein. 53 62
16190658 2005
20
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. 53 62
15990789 2005
21
Evaluation of the utility of atopy patch testing, skin prick testing, and total and specific IgE assays in the diagnosis of cow's milk allergy. 53 62
15945559 2005
22
Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge. 53 62
15572894 2004
23
Association between CD62 ligand on naïve and memory T cells and history of cow's milk hypersensitivity in atopic patients. 53 62
15191026 2004
24
Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants. 53 62
14630983 2004
25
Cow's milk stimulated lymphocyte proliferation and TNFalpha secretion in hypersensitivity to cow's milk protein. 53 62
14597219 2003
26
[CD69 and PCNA expression of T-lymphocytes from children with cow's milk allergy (CMA)]. 53 62
15213371 2003
27
[Prevalence of soya allergy in children with cow's milk allergy]. 53 62
12878795 2003
28
Identification of sequential IgE-binding epitopes on bovine alpha(s2)-casein in cow's milk allergic patients. 53 62
12373003 2002
29
Serum immunoglobulin E, IgA, and IgG antibodies to different cow's milk proteins in children with cow's milk allergy: association with prognosis and clinical manifestations. 53 62
12390441 2002
30
B-cell epitopes as a screening instrument for persistent cow's milk allergy. 53 62
12170271 2002
31
Markers of inflammation in the feces of infants with cow's milk allergy. 53 62
12144641 2002
32
Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy. 53 62
11678861 2001
33
IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. 53 62
11729348 2001
34
Structure and function of proteins involved in milk allergies. 53 62
11419710 2001
35
Higher serum eosinophil cationic protein levels in children with cow's milk allergy. 53 62
11396817 2001
36
Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy. 53 62
11260154 2001
37
[Serum eosinophil cationic protein (sECP) level after cow's milk challenge test in allergic children]. 53 62
11196237 2000
38
[Study on casein allergy in children]. 53 62
11193464 2000
39
Does low IgA in human milk predispose the infant to development of cow's milk allergy? 53 62
11004235 2000
40
Anaphylaxis caused by the unexpected presence of casein in salmon. 53 62
10609826 1999
41
Cow's milk casein, a hidden allergen in natural rubber latex gloves. 53 62
10400857 1999
42
In vivo and in vitro studies on the residual allergenicity of partially hydrolysed infant formulae. 53 62
10342536 1999
43
Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations. 53 62
10094375 1999
44
Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine alpha(s)1-casein from the same patients allergic to cow's milk: existence of alpha(s)1-casein-specific B cells and T cells characteristic in cow's-milk allergy. 53 62
9600504 1998
45
The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity. 53 62
9357936 1997
46
Monoclonal and polyclonal antibodies against casein components of cow milk for evaluation of residual antigenic activity in 'hypoallergenic' infant formulas. 53 62
9291294 1997
47
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk. 53 62
8648027 1996
48
Establishment and characterization of alpha s1-casein-specific T-cell lines from patients allergic to cow's milk: unexpected higher frequency of CD8+ T-cell lines. 53 62
8648031 1996
49
Specific serum IgE in the diagnosis of egg and milk allergy in adults. 53 62
7503399 1995
50
Evaluation of lymphocyte proliferative responses to casein hydrolysate formula in cow's milk-sensitive children: response of peripheral blood mononuclear cells to hydrolysate formula. 53 62
7655706 1995

Variations for Milk Allergy

Expression for Milk Allergy

Search GEO for disease gene expression data for Milk Allergy.

Pathways for Milk Allergy

Pathways related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 TGFB2 IL5 IL4 IL13 IL10 CD4
2
Show member pathways
13.17 TGFB2 IL5 IL4 IL13 IL10 CD4
3
Show member pathways
12.53 TGFB2 IL5 IL4 IL13 IL10
4
Show member pathways
12.03 IL5 IL4 IL10 CD4
5 11.98 TGFB2 IL4 IL13 IL10
6 11.91 CD4 CD69 CD79A IL10 IL4 IL5
7 11.84 IL4 IL13 IL10
8 11.82 IL5 IL4 IL13 IL10 FOXP3
9
Show member pathways
11.75 TGFB2 IL4 CD4
10 11.7 CSN2 IL13 IL4 IL5
11 11.65 IL4 IL10 CD79A CD69
12 11.61 IL10 IL4 IL5
13 11.61 CD4 FOXP3 IL4
14
Show member pathways
11.59 IL5 IL4 FOXP3
15
Show member pathways
11.57 IL5 IL4 IL13 IL10 FOXP3
16 11.55 IL5 IL4 IL13
17 11.52 IL5 IL4 IL10
18 11.28 TSLP IL5 IL4 IL13
19
Show member pathways
11.26 TGFB2 IL10 FOXP3
20 11.15 IL5 IL4 IL13 IL10
21 11.12 IL5 IL4 IL13 IL10 CD4
22 11.1 IL5 IL4 IL13 IL10 FOXP3 CD4
23 11.07 TSLP IL5 IL4 IL13 IL10 CD4
24 10.99 TGFB2 IL5 IL4 IL13 IL10
25 10.91 TGFB2 IL5 IL4 IL13 IL10
26 10.8 IL4 CD4
27 10.7 TGFB2 IL5 IL4 IL13

GO Terms for Milk Allergy

Cellular components related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 CSN1S1 CSN2 CSN3 IGHE IL10 IL13
2 external side of plasma membrane GO:0009897 9.93 IL13 IGHE CD79A CD69 CD4 CCR6
3 extracellular space GO:0005615 9.7 TSLP TGFB2 RNASE3 LALBA IL5 IL4

Biological processes related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 9.95 IL5 IL4 IL13
2 negative regulation of inflammatory response GO:0050728 9.95 IL4 IL13 IL10 FOXP3
3 positive regulation of interleukin-10 production GO:0032733 9.91 TSLP IL4 IL13
4 type 2 immune response GO:0042092 9.8 IL4 IL10
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.73 IL4 IL13 IL10
6 negative regulation of chronic inflammatory response GO:0002677 9.67 FOXP3 IL4
7 regulation of isotype switching GO:0045191 9.62 IL10 IL4
8 regulation of complement-dependent cytotoxicity GO:1903659 9.46 TGFB2 IL10
9 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL4 IL13
10 immune response GO:0006955 9.44 IL5 IL4 IL13 IL10 IGHE CD4
11 positive regulation of immunoglobulin production GO:0002639 9.43 IL5 IL13 IL10

Molecular functions related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 TSLP TGFB2 IL5 IL4 IL13 IL10

Sources for Milk Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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