MCID: MLK006
MIFTS: 47

Milk Allergy

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Milk Allergy

MalaCards integrated aliases for Milk Allergy:

Name: Milk Allergy 12 15
Milk Allergic Reaction 12 17
Milk Hypersensitivity 44 70
Allergy Milk 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4376
MeSH 44 D016269
UMLS 70 C0079840

Summaries for Milk Allergy

Disease Ontology : 12 A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

MalaCards based summary : Milk Allergy, also known as milk allergic reaction, is related to cow milk allergy and lactose intolerance. An important gene associated with Milk Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Omalizumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, small intestine and colon, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 73 Milk allergy is an adverse immune reaction to one or more proteins in cow's milk. When allergy symptoms... more...

Related Diseases for Milk Allergy

Diseases related to Milk Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 423)
# Related Disease Score Top Affiliating Genes
1 cow milk allergy 32.1 LALBA IL5 IL4 IL10 CSN3 CSN2
2 lactose intolerance 32.0 LALBA IL10 CSN2 CSN1S1
3 enterocolitis 31.1 TNF IL10
4 cholera 30.5 TNF IL4 IL10 CD79A
5 eosinophilic gastroenteritis 30.4 RNASE3 IL5 IL4
6 gastroesophageal reflux 30.4 TNF IL5 IL4 FOXP3
7 perinatal necrotizing enterocolitis 30.3 TNF IL10 CSN1S1
8 gastroenteritis 30.2 TNF RNASE3 IL5 IL4 IL10
9 ige responsiveness, atopic 30.0 RNASE3 IL5 IL4 IL13 IL10 IGHE
10 urticaria 30.0 TNF RNASE3 IL5 IL4 IL13 IL10
11 cytokine deficiency 30.0 IL9 IL5 IL13
12 neurodermatitis 29.9 IL4 IL13
13 diarrhea 29.9 TNF IL5 IL13 IL10 FOXP3
14 eosinophilic gastritis 29.9 IL5 IL13
15 transient hypogammaglobulinemia 29.8 TNF IL10
16 irritable bowel syndrome 29.8 TNF IL4 IL10
17 egg allergy 29.7 LALBA IL5 IL4 IL13 IL10 IGHE
18 chronic rhinitis 29.7 RNASE3 IL5 IL4 IL13
19 rubella 29.6 TNF IL5 IL4 IL10
20 diphtheria 29.6 TNF IL5 IL4 IL13
21 peritonitis 29.6 TNF IL4 IL10 CD69
22 kawasaki disease 29.6 TNF IL4 IL10 FOXP3
23 otitis media 29.5 TNF RNASE3 IL5 IL4 IL10 IGHE
24 colitis 29.5 TNF IL4 IL13 IL10 FOXP3
25 ulcerative colitis 29.4 TNF IL4 IL13 IL10
26 dermatitis 29.4 TNF RNASE3 IL5 IL4 IL13 IL10
27 pollen allergy 29.4 RNASE3 IL5 IL13 IGHE FOXP3
28 chronic urticaria 29.3 TNF RNASE3 IL4 IL13 IGHE
29 respiratory allergy 29.3 RNASE3 IL5 IL4 IL13 IL10 IGHE
30 respiratory failure 29.3 TNF RNASE3 IL5 IL13 IL10
31 hypereosinophilic syndrome 29.2 RNASE3 IL9 IL5 IL4 IL13 IGHE
32 contact dermatitis 29.2 TNF IL9 IL5 IL4 IL10
33 arthritis 29.2 TNF IL4 IL13 IL10 FOXP3
34 crohn's disease 29.1 TNF IL4 IL13 IL10 FOXP3
35 esophagitis, eosinophilic, 1 29.1 STAT6 RNASE3 IL9 IL5 IL4 IL13
36 esophagitis 29.1 TNF STAT6 RNASE3 IL5 IL4 IL13
37 allergic rhinitis 29.0 RNASE3 IL9 IL5 IL4 IL13 IL10
38 peanut allergy 29.0 IL9 IL5 IL4 IL13 IL10 IGHE
39 rhinitis 29.0 TNF RNASE3 IL9 IL5 IL4 IL13
40 thrombocytopenia 29.0 TNF IL9 IL4 IL10 FOXP3 CD79A
41 nephrotic syndrome 29.0 TNF IL4 IL13 IGES CD79A
42 severe combined immunodeficiency, x-linked 28.9 STAT6 IL9 IL4 IL13
43 proteasome-associated autoinflammatory syndrome 1 28.9 TNF RNASE3 IL5 IL4 IL13 IL10
44 food allergy 28.8 TNF STAT6 RNASE3 IL5 IL4 IL13
45 allergic disease 28.8 TNF RNASE3 IL9 IL5 IL4 IL13
46 tetanus 28.8 TNF IL9 IL5 IL4 IL13 IL10
47 hyper ige syndrome 28.8 TNF RNASE3 IL4 IL13 IL10 IGHE
48 severe combined immunodeficiency 28.7 STAT6 IL9 IL4 IL13 IL10
49 bronchitis 28.6 TNF RNASE3 IL9 IL5 IL4 IL13
50 celiac disease 1 28.6 TNF LALBA IL9 IL5 IL4 IL13

Graphical network of the top 20 diseases related to Milk Allergy:



Diseases related to Milk Allergy

Symptoms & Phenotypes for Milk Allergy

MGI Mouse Phenotypes related to Milk Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 CD69 CD79A FOXP3 IL10 IL13 IL4
2 endocrine/exocrine gland MP:0005379 10.1 CSN2 CSN3 FOXP3 IL10 IL13 IL4
3 immune system MP:0005387 10.06 CD69 CD79A FOXP3 IL10 IL13 IL4
4 digestive/alimentary MP:0005381 10.03 FOXP3 IL10 IL13 IL4 IL5 IL9
5 integument MP:0010771 9.91 CSN2 CSN3 FOXP3 IL10 IL13 IL4
6 liver/biliary system MP:0005370 9.7 CD79A FOXP3 IL10 IL4 IL5 STAT6
7 no phenotypic analysis MP:0003012 9.5 CD69 CD79A FOXP3 IL10 IL13 IL4
8 respiratory system MP:0005388 9.23 FOXP3 IL10 IL13 IL4 IL5 STAT6

Drugs & Therapeutics for Milk Allergy

Drugs for Milk Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2 Antibodies Phase 1, Phase 2
3 Immunoglobulins, Intravenous Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2
5 Immunoglobulin E Phase 1, Phase 2
6 Anti-Asthmatic Agents Phase 2
7 Respiratory System Agents Phase 2
8 Immunologic Factors Phase 2
9 Antibodies, Monoclonal Phase 2
10 Anti-Allergic Agents Phase 2
11 Vaccines Phase 2
12 Acidophilus Phase 2
13 Caseins Phase 2
14 Chelating Agents Phase 2
15 Cassava Phase 1
16
tannic acid Approved 1401-55-4
17
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
18
Calcium carbonate Approved, Investigational 471-34-1
19 Calcium, Dietary
20 Complement System Proteins
21 Dermatologic Agents
22 Whey Protein
23 Soy Bean
24 Nutrients
25
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study: Milk Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
2 Parmigiano-Reggiano Cheese as a Possible Strategy of Immunonutrition Able to Stimulate the Acquisition of Oral Tolerance in Childre With Cow's Milk Allergy Unknown status NCT02081651 Phase 3
3 Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy Completed NCT02351531 Phase 3
4 Evaluation of the Hypoallergenicity of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow's Milk Protein Allergy Completed NCT02711163 Phase 3
5 EPIGENETIC EFFECTS ELICITED BY LACTOBACILLUS GG IN CHILDREN WITH COW'S MILK ALLERGY: A POSSIBLE EFFECT OF ATOPIC MARCH Unknown status NCT02062476 Phase 2
6 Cow's Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula (TeHF2013-01) in Infants With Confirmed Cow's Milk Protein Allergy Unknown status NCT02149134 Phase 2
7 A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy Completed NCT00465569 Phase 1, Phase 2 cow's milk powder
8 The Effectiveness of Milk Allergy Elimination Through NAET Treatments Completed NCT00328731 Phase 1, Phase 2
9 Tolerability to a New Free Amino Acid-based Formula in Children With Cow's Milk Protein Allergy Completed NCT02536482 Phase 2
10 Oral Immunotherapy Combined With Humanized Monoclonal Anti-IgE Antibody Xolair® (Omalizumab)in the Treatment of Cow's Milk Allergy Completed NCT01157117 Phase 2 Milk powder
11 Efficacy of Baked Milk in Accelerating Resolution of Cow's Milk Allergy Completed NCT02738060 Phase 2
12 The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy Completed NCT00732654 Phase 1, Phase 2 Milk Protein Extract Immunotherapy goal of 4mg/day;Milk Protein Extract Immunotherapy goal of 7mg/day;Milk Powder Immunotherapy goal dose 2000 mg/day;Milk Powder Immunotherapy goal dose 1000mg/day
13 Dietary Intervention in Milk Allergy and Tolerance Development Completed NCT00778258 Phase 2
14 A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow's Milk Allergy in Children Completed NCT02223182 Phase 1, Phase 2
15 A Double, Blind Placebo-controlled, Randomized Trial to Study Efficacy and Safety of the Viaskin Milk for Treating Milk Induced Eosinophilic Esophagitis in Children Completed NCT02579876 Phase 2 Viaskin Milk 500 mcg;Viaskin Placebo
16 A Phase 2 Study to Evaluate the Sensitivity, Specificity and Safety of DBV1605, a Ready-to-Use Atopy Patch Test for the Diagnosis of Non-Immunoglobulin E Mediated Cow's Milk Allergy in Children Recruiting NCT04492683 Phase 2
17 A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab and Milk Oral Immunotherapy for the Treatment of Patients With Cow's Milk Allergy Not yet recruiting NCT04148352 Phase 2 Dupilumab
18 A Prospective Randomized Controlled Trial to Evaluate the Effect of Infant Formula on the Resolution of Cow's Milk Allergy of Infancy Terminated NCT02719405 Phase 2
19 Phase I Study of Baked Milk Oral Immunotherapy for the Treatment of Cow's Milk Allergy Active, not recruiting NCT03462030 Phase 1 Baked non-fat cow's milk powder;Placebo: Tapioca Powder
20 Tolerability of the New Hypoallergenic Formula in Children With IgE Mediated Cow's Milk Allergy Unknown status NCT03909113
21 Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora Unknown status NCT00298376
22 Preventive Effect of Lactobacillus GG on Atopic Manifestation in Children With Cow's Milk Allergy Unknown status NCT01891916
23 Comiss Score Fore Detection of Cow's Milk Protein Allergy Unknown status NCT03664076
24 Milk Desensitization and Induction of Tolerance in Children Unknown status NCT03644381
25 Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University Unknown status NCT03456479
26 Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy Unknown status NCT02087930
27 Assessment of Cow's Milk-related Symptom Scoring Awareness Tool in Young Turkish Children Unknown status NCT03223181
28 DETERMINATION OF HYPOALLERGENICITY TO SUBSTITUTIVE FORMULAS IN CHILDREN WITH COW'S MILK ALLERGY Unknown status NCT02144428
29 Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients Unknown status NCT01968278
30 The Evaluation of the Effects of an Extensive Casein Hydrolysate Containing the Probiotic Lactobacillus Rhamnosus GG as a Possible Step Down Approach Able to Stimulate the Acquisition of Immunological Tolerance Compared to an Amino Acid Formula in Children Affected by Cow's Milk Protein Allergy Unknown status NCT03449537
31 Cow's Milk Allergy in Infants With Obstructive Sleep Apnea Unknown status NCT00659854
32 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
33 Young Adults With Life Threatening Cow's Milk Allergy: Risks of Decrease Bone Mineralization and Methods of Calcium Supplementation Unknown status NCT01930266
34 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
35 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
36 A Multicenter, Single-blind, Randomized, Phase II Study of the Tolerability and Safety of NPS-202 in Infants With Clinically Diagnosed Cow's Milk Allergy Completed NCT00938483
37 Use of Fermented Milk in Prevention of Cow's Milk Allergy in New Born and Infant Completed NCT00792090
38 A Prospective, Open-label, Post-marketing Observational Study to Document the Use of Soy-based Infant Formula With Low Chain Polyunsaturates (LCP) in Infants With Symptoms Suggestive to Cow's Milk Allergy Completed NCT01809951
39 Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy Completed NCT02779881
40 Camel's Milk as a Safe Alternative in Cow's Milk Allergy Completed NCT01223885
41 Xolair (Omalizumab) Enhances Oral Tolerance Induction in Milk Allergic Children Completed NCT00968110 Early Phase 1 omalizumab
42 A Double-Blind, Randomized, Crossover Allergy Study of an Experimental Formula Followed by a 16 Week Double Blind Feeding Period to Assess Growth, Safety and Development of Tolerance to Cow's Milk Protein Completed NCT02317952
43 Symptoms Based Awareness Confirmation Study - CoMiSS Validation Completed NCT03004729
44 Effect of Lactobacillus GG on the Appearance of Functional Gastrointestinal Disorders in Children With Cow's Milk Allergy Completed NCT01901380
45 Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides: Comparison With World Health Organization (WHO) Growth Standards in an Observational, Single-arm Study Completed NCT03661736
46 Evaluation of the Hypoallergenicity of a New Formula Based on Hydrolyzed Rice Proteins (TRHF 2017) in Children With Confirmed Immunoglobulin E (IgE) or Non-immunoglobulin E-mediated Cow's Milk Allergy (CMA) Completed NCT03557671
47 Effect of Therapy With Aminoacid Based Formula Versus Hydrolyzed Whey Proteins in Children With Cow's Milk Allergy Completed NCT02379598
48 Sublingual Milk Immunotherapy in Children With IgE-mediated Cow Milk Protein Allergy Completed NCT00874627
49 Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy Completed NCT01622426
50 Epigenetic Effects Involved in Children With Cow's Milk Allergy: A Possible Effect of Atopic March of Lactobacillus GG (EPICMA) Completed NCT02466035

Search NIH Clinical Center for Milk Allergy

Cochrane evidence based reviews: milk hypersensitivity

Genetic Tests for Milk Allergy

Anatomical Context for Milk Allergy

MalaCards organs/tissues related to Milk Allergy:

40
T Cells, Small Intestine, Colon, Skin, Bone, Breast, B Cells

Publications for Milk Allergy

Articles related to Milk Allergy:

(show top 50) (show all 1691)
# Title Authors PMID Year
1
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. 61 54
20462631 2010
2
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. 54 61
20226304 2010
3
Peptides surviving the simulated gastrointestinal digestion of milk proteins: biological and toxicological implications. 54 61
19962948 2010
4
[Sensitization to casein and beta-lactoglobulin (BLG) in children with cow's milk allergy (CMA)]. 61 54
20212353 2010
5
Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis. 61 54
20079488 2010
6
Effects of heating and glycation of beta-lactoglobulin on its recognition by IgE of sera from cow milk allergy patients. 54 61
19489627 2009
7
Eliciting doses of positive challenge test in cow's milk allergy are related to cow's milk specific IgE levels. 61 54
19150029 2008
8
Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. 61 54
18384430 2008
9
Usefulness of specific IgE levels in predicting cow's milk allergy. 61 54
18155280 2008
10
The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. 54 61
17651374 2007
11
Sensitization to serum albumins in children allergic to cow's milk and epithelia. 61 54
17680908 2007
12
Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. 61 54
17573720 2007
13
Maintenance of tolerance to cow's milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. 61 54
17581206 2007
14
Casein-specific immunoglobulins in cow's milk allergic patient subgroups reveal a shift to IgA dominance in tolerant patients. 54 61
17295802 2007
15
Memory T cell proliferation in cow's milk allergy after CD25+ regulatory T cell removal suggests a role for casein-specific cellular immunity in IgE-mediated but not in non-IgE-mediated cow's milk allergy. 61 54
17106206 2007
16
Effect of extensively hydrolyzed milk formula on growth and resistance to bronchitis and atopic dermatitis in infants and toddlers. 54 61
16784012 2006
17
IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients. 61 54
17039668 2006
18
Z-score of weight for age of infants with atopic dermatitis and cow's milk allergy fed with a rice-hydrolysate formula during the first two years of life. 54 61
16214777 2005
19
Human IgE binding to the glycosidic moiety of bovine kappa-casein. 61 54
16190658 2005
20
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. 61 54
15990789 2005
21
Evaluation of the utility of atopy patch testing, skin prick testing, and total and specific IgE assays in the diagnosis of cow's milk allergy. 54 61
15945559 2005
22
Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge. 54 61
15572894 2004
23
Association between CD62 ligand on naïve and memory T cells and history of cow's milk hypersensitivity in atopic patients. 61 54
15191026 2004
24
Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants. 61 54
14630983 2004
25
Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. 61 54
14760265 2004
26
[Interleukin 13 and 18 serum concentration in children with cow milk hypersensitivity]. 54 61
15557695 2004
27
Cow's milk stimulated lymphocyte proliferation and TNFalpha secretion in hypersensitivity to cow's milk protein. 61 54
14597219 2003
28
[CD69 and PCNA expression of T-lymphocytes from children with cow's milk allergy (CMA)]. 61 54
15213371 2003
29
[Prevalence of soya allergy in children with cow's milk allergy]. 54 61
12878795 2003
30
Identification of sequential IgE-binding epitopes on bovine alpha(s2)-casein in cow's milk allergic patients. 54 61
12373003 2002
31
B-cell epitopes as a screening instrument for persistent cow's milk allergy. 61 54
12170271 2002
32
Serum immunoglobulin E, IgA, and IgG antibodies to different cow's milk proteins in children with cow's milk allergy: association with prognosis and clinical manifestations. 54 61
12390441 2002
33
Markers of inflammation in the feces of infants with cow's milk allergy. 54 61
12144641 2002
34
IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. 54 61
11729348 2001
35
Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy. 61 54
11678861 2001
36
Structure and function of proteins involved in milk allergies. 54 61
11419710 2001
37
Higher serum eosinophil cationic protein levels in children with cow's milk allergy. 54 61
11396817 2001
38
Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy. 61 54
11260154 2001
39
[Serum eosinophil cationic protein (sECP) level after cow's milk challenge test in allergic children]. 54 61
11196237 2000
40
[Study on casein allergy in children]. 61 54
11193464 2000
41
Does low IgA in human milk predispose the infant to development of cow's milk allergy? 54 61
11004235 2000
42
Anaphylaxis caused by the unexpected presence of casein in salmon. 54 61
10609826 1999
43
Cow's milk casein, a hidden allergen in natural rubber latex gloves. 54 61
10400857 1999
44
In vivo and in vitro studies on the residual allergenicity of partially hydrolysed infant formulae. 61 54
10342536 1999
45
Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations. 54 61
10094375 1999
46
Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine alpha(s)1-casein from the same patients allergic to cow's milk: existence of alpha(s)1-casein-specific B cells and T cells characteristic in cow's-milk allergy. 54 61
9600504 1998
47
The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity. 61 54
9357936 1997
48
Monoclonal and polyclonal antibodies against casein components of cow milk for evaluation of residual antigenic activity in 'hypoallergenic' infant formulas. 61 54
9291294 1997
49
Establishment and characterization of alpha s1-casein-specific T-cell lines from patients allergic to cow's milk: unexpected higher frequency of CD8+ T-cell lines. 61 54
8648031 1996
50
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk. 61 54
8648027 1996

Variations for Milk Allergy

Expression for Milk Allergy

Search GEO for disease gene expression data for Milk Allergy.

Pathways for Milk Allergy

Pathways related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 TNF TGFB2 STAT6 IL9 IL5 IL4
2
Show member pathways
13.37 TNF TGFB2 STAT6 IL9 IL5 IL4
3
Show member pathways
13.33 TNF STAT6 IL9 IL5 IL4 IL13
4
Show member pathways
13.25 TNF TGFB2 IL9 IL5 IL4 IL13
5
Show member pathways
12.85 TNF RNASE3 IL9 IL5 IL4 IL13
6 12.79 TGFB2 STAT6 IL5 IL4 IL13
7
Show member pathways
12.59 TNF IL4 IL10 IGHE CD79A
8
Show member pathways
12.59 TNF IL5 IL4 IL13 IGHE CD79A
9
Show member pathways
12.57 TNF IL9 IL5 IL4 IL10
10 12.57 TNF STAT6 IL4 IL10 FOXP3 CD79A
11
Show member pathways
12.57 TNF TGFB2 STAT6 IL5 IL4 IL13
12
Show member pathways
12.42 STAT6 IL9 IL5 IL4 IL13 IL10
13
Show member pathways
12.29 TNF IL5 IL4 IL13
14
Show member pathways
12.28 TNF TGFB2 IL9 IL5 IL4 IL13
15
Show member pathways
12.22 TNF TGFB2 IL4 IL10
16 12.02 TNF IL5 IL4 IL10 CD79A CD69
17 11.99 TNF STAT6 IL4 IL13 IL10 IGHE
18 11.85 TNF TGFB2 IL10
19 11.84 TNF IL5 IL4
20 11.83 IL5 IL4 IL13 CSN2
21
Show member pathways
11.78 TNF IL5 IL4 FOXP3
22 11.75 TNF IL9 IL5 IL4 IL13 IL10
23 11.69 STAT6 IL9 IL4
24 11.69 TNF IL5 IL4 IL13
25 11.69 STAT6 IL5 IL4 IL10 IGHE
26 11.55 TNF IL4 IL13 IL10
27 11.51 TNF TGFB2 IL10
28 11.45 TNF TGFB2 IL5 IL4 IL10 FOXP3
29
Show member pathways
11.39 TNF TGFB2 IL10 FOXP3
30 11.31 TNF IL9 IL5 IL4 IL13
31 11.18 TNF IL5 IL4 IL13 IL10
32 11.07 IL9 IL5 IL4 IL13 IL10
33 11.01 TGFB2 STAT6 IL4
34 11.01 TNF TGFB2 IL9 IL5 IL4 IL13
35 10.83 STAT6 IL9 IL5 IL4 IL13 IL10
36 10.43 TGFB2 IL9 IL5 IL4 IL13

GO Terms for Milk Allergy

Cellular components related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF TGFB2 RNASE3 LALBA IL9 IL5
2 external side of plasma membrane GO:0009897 9.55 TNF IL13 IGHE CD79A CD69
3 extracellular space GO:0005615 9.4 TNF TGFB2 RNASE3 LALBA IL9 IL5

Biological processes related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.83 STAT6 IL4 IL13
2 B cell differentiation GO:0030183 9.81 IL4 IL10 CD79A
3 negative regulation of tumor necrosis factor production GO:0032720 9.8 IL4 IL10 FOXP3
4 negative regulation of interleukin-6 production GO:0032715 9.78 TNF IL10 FOXP3
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 TNF IL4 IL13
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.72 TNF TGFB2 IL10
7 positive regulation of B cell proliferation GO:0030890 9.71 IL5 IL4 IL13
8 negative regulation of inflammatory response GO:0050728 9.71 IL4 IL13 IL10 FOXP3
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.7 IL4 IL13 IL10
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 TNF IL10
11 macrophage activation GO:0042116 9.65 IL4 IL13
12 defense response to bacterium GO:0042742 9.65 TNF RNASE3 LALBA IL10 IGHE
13 positive regulation of podosome assembly GO:0071803 9.64 TNF IL5
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL4 IL10
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.62 IL4 FOXP3
16 positive regulation of mast cell degranulation GO:0043306 9.62 IL4 IL13
17 regulation of immunoglobulin production GO:0002637 9.61 TNF FOXP3
18 endothelial cell apoptotic process GO:0072577 9.59 TNF IL10
19 regulation of complement-dependent cytotoxicity GO:1903659 9.58 TGFB2 IL10
20 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF IL4
21 negative regulation of cytokine production involved in immune response GO:0002719 9.57 TNF IL10
22 type 2 immune response GO:0042092 9.56 IL4 IL10
23 positive regulation of JAK-STAT cascade GO:0046427 9.54 TNF IL5 IL10
24 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL4 IL13
25 microglial cell activation GO:0001774 9.5 TNF IL4 IL13
26 immune response GO:0006955 9.5 TNF IL9 IL5 IL4 IL13 IL10
27 positive regulation of isotype switching to IgE isotypes GO:0048295 9.49 STAT6 IL4
28 regulation of isotype switching GO:0045191 9.48 IL4 IL10
29 negative regulation of alkaline phosphatase activity GO:0010693 9.46 TNF TGFB2
30 negative regulation of chronic inflammatory response GO:0002677 9.43 IL4 FOXP3
31 positive regulation of immunoglobulin production GO:0002639 9.33 IL5 IL13 IL10
32 cytokine-mediated signaling pathway GO:0019221 9.17 TNF STAT6 IL5 IL4 IL13 IL10

Molecular functions related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 TGFB2 IL9 IL5 IL4 IL10
2 cytokine receptor binding GO:0005126 9.33 IL9 IL4 IL13
3 cytokine activity GO:0005125 9.17 TNF TGFB2 IL9 IL5 IL4 IL13

Sources for Milk Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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