Milk Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Milk Allergy

MalaCards integrated aliases for Milk Allergy:

Name: Milk Allergy ¹¹ ¹⁴ ⁷⁵

Milk Allergic Reaction ¹¹ ¹⁶

Milk Hypersensitivity ⁴³ ⁷¹

Allergy Milk ⁵³

Classifications:

MalaCards categories:
Anatomical: Immune diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4376

MeSH ⁴³ D016269

EFO ¹⁶ EFO_0007369

UMLS ⁷¹ C0079840

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Summaries for Milk Allergy

Disease Ontology: ¹¹ A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

MalaCards based summary: Milk Allergy, also known as milk allergic reaction, is related to goat milk allergy and lactose intolerance. An important gene associated with Milk Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Soy Bean and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and t cells, and related phenotypes are endocrine/exocrine gland and no phenotypic analysis

Wikipedia: ⁷⁵ Milk allergy is an adverse immune reaction to one or more proteins in cow's milk. Among the possible... more...

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Related Diseases for Milk Allergy

Diseases related to Milk Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)

#	Related Disease	Score	Top Affiliating Genes
1	goat milk allergy	32.6	TSLP CSN2 CSN1S1
2	lactose intolerance	31.8	LALBA IL10 CSN2 CSN1S1
3	chronic rhinitis	30.6	RNASE3 PEDS1 IL5 IL4 IL13
4	eosinophilic gastroenteritis	30.5	RNASE3 IL5 IL4 IL13 IGHE
5	cholera	30.4	IL5 IL4 IL10 CD79A
6	cow milk allergy	30.3	PEDS1 LALBA IL5 IL4 IL13 IL10
7	gastroenteritis	30.3	RNASE3 IL5 IL4 IL10
8	diarrhea	30.1	IL5 IL13 IL10 FOXP3
9	enterobiasis	30.1	IL5 IL4
10	ige responsiveness, atopic	30.1	RNASE3 IL5 IL4 IL13 IL10 IGHE
11	chronic urticaria	30.0	RNASE3 IL5 IGHE
12	wheat allergy	29.9	PEDS1 IGHE
13	rubella	29.8	IL5 IL4 IL10
14	esophagitis, eosinophilic, 1	29.8	TSLP RNASE3 IL5 IL4 IL13 CCR6
15	neurodermatitis	29.8	TSLP IL4 IL13
16	eosinophilic gastritis	29.8	TSLP IL5 IL13
17	exanthem	29.8	IL4 IL10 CD4 CCR6
18	diphtheria	29.7	IL5 IL4 IL13
19	severe combined immunodeficiency, x-linked	29.7	TSLP IL4 IL13
20	esophagitis	29.7	TSLP RNASE3 IL5 IL4 IL13 IL10
21	hypereosinophilic syndrome	29.7	RNASE3 IL5 IL4 IL13 IL10 IGHE
22	allergic rhinitis	29.6	RNASE3 IL5 IL4 IL13 IL10 IGHE
23	giardiasis	29.6	IL10 CD79A CD4
24	extrinsic allergic alveolitis	29.6	TGFB2 IGHE CD4 CCR6
25	tetanus	29.5	IL5 IL4 IL13 IL10 CD79A
26	pneumonia	29.5	IL5 IL4 IL13 IL10
27	otitis media	29.4	RNASE3 IL5 IL4 IL13 IL10 IGHE
28	urticaria	29.4	TSLP RNASE3 IL5 IL4 IL13 IL10
29	rhinitis	29.4	TSLP RNASE3 IL5 IL4 IL13 IL10
30	perinatal necrotizing enterocolitis	29.4	LALBA IL10 CSN1S1 CD4 CCR6
31	miliary tuberculosis	29.3	IL4 IL10 CD4
32	immunoglobulin alpha deficiency	29.3	IL10 CD79A CD4 CCR6
33	intestinal perforation	29.2	IL10 CD4 CCR6
34	aphthous stomatitis	29.2	IL10 CD4 CCR6
35	dysentery	29.2	IL10 CD4 CCR6
36	dermatitis	29.2	TSLP RNASE3 IL5 IL4 IL13 IL10
37	proteasome-associated autoinflammatory syndrome 1	29.2	RNASE3 IL5 IL4 IL13 IL10 IGHE
38	bronchitis	29.2	RNASE3 IL5 IL4 IL13 IL10 IGHE
39	nephrotic syndrome	29.1	IL4 IL13 IGES CD79A CD4
40	type 1 diabetes mellitus	28.9	IL4 IL10 FOXP3 CSN2 CD79A CCR6
41	inflammatory bowel disease	28.8	RNASE3 IL5 IL4 IL13 IL10 FOXP3
42	conjunctivitis	28.8	RNASE3 IL5 IL4 IL13 IL10 IGHE
43	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	28.7	IL4 IL10 FOXP3 CD4 CCR6
44	allergic asthma	28.6	TSLP RNASE3 IL5 IL4 IL13 IL10
45	colitis	28.6	IL5 IL4 IL13 IL10 FOXP3 CD4
46	hyper ige syndrome	28.5	RNASE3 IL4 IL10 IGHE IGES CD4
47	occupational asthma	28.5	TSLP RNASE3 PEDS1 IL5 IL4 IL13
48	allergic disease	28.5	TSLP RNASE3 LALBA IL5 IL4 IL13
49	food allergy	28.3	TSLP RNASE3 PEDS1 LALBA IL5 IL4
50	immune deficiency disease	28.2	IL4 IL13 IL10 FOXP3 CD79A CD69

Graphical network of the top 20 diseases related to Milk Allergy:

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Symptoms & Phenotypes for Milk Allergy

MGI Mouse Phenotypes related to Milk Allergy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.06	CD4 CSN1S1 CSN2 CSN3 EHF FOXP3
2	no phenotypic analysis	MP:0003012	9.97	CD4 CD69 CD79A FOXP3 IGHE IL10
3	immune system	MP:0005387	9.93	CCR6 CD4 CD69 CD79A FOXP3 IGHE
4	digestive/alimentary	MP:0005381	9.91	CD4 EHF FOXP3 IL10 IL13 IL4
5	hematopoietic system	MP:0005397	9.77	CCR6 CD4 CD69 CD79A FOXP3 IGHE
6	integument	MP:0010771	9.32	CD4 CSN1S1 CSN2 CSN3 FOXP3 IL10

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Drugs & Therapeutics for Milk Allergy

Drugs for Milk Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Soy Bean

Phase 4

2

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

3

Immunoglobulins, Intravenous

Phase 1, Phase 2

4

Immunoglobulins

Phase 2

5

Immunoglobulin E

Phase 1, Phase 2

6

Antibodies

Phase 2

7

Immunologic Factors

Phase 2

8

Anti-Asthmatic Agents

Phase 2

9

Anti-Allergic Agents

Phase 2

10

Respiratory System Agents

Phase 2

11

Antibodies, Monoclonal

Phase 2

12

Vaccines

Phase 2

13

Cassava

Phase 2

14

Caseins

Phase 2

15

Acidophilus

Phase 2

16

Chelating Agents

Phase 2

17

Calcium carbonate

Approved, Investigational

471-34-1

18

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

19

Tannic acid

Approved

1401-55-4

16129878 16129778

20

Calcium, Dietary

21

Dermatologic Agents

22

Complement System Proteins

23

Whey Protein

24

Calcium

Nutraceutical

7440-70-2

271

Interventional clinical trials:

(show top 50) (show all 105)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 4 Study: Milk Oral Immunotherapy for Cow's Milk Allergy in School-aged Children	Completed	NCT01361347	Phase 4
2	Parmigiano-Reggiano Cheese as a Possible Strategy of Immunonutrition Able to Stimulate the Acquisition of Oral Tolerance in Childre With Cow's Milk Allergy	Unknown status	NCT02081651	Phase 3
3	Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy	Completed	NCT02351531	Phase 3
4	Evaluation of the Hypoallergenicity of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow's Milk Protein Allergy	Completed	NCT02711163	Phase 3
5	Cow's Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula (TeHF2013-01) in Infants With Confirmed Cow's Milk Protein Allergy	Unknown status	NCT02149134	Phase 2
6	EPIGENETIC EFFECTS ELICITED BY LACTOBACILLUS GG IN CHILDREN WITH COW'S MILK ALLERGY: A POSSIBLE EFFECT OF ATOPIC MARCH	Unknown status	NCT02062476	Phase 2
7	Efficacy of Baked Milk in Accelerating Resolution of Cow's Milk Allergy	Completed	NCT02738060	Phase 2
8	A Double, Blind Placebo-controlled, Randomized Trial to Study Efficacy and Safety of the Viaskin Milk for Treating Milk Induced Eosinophilic Esophagitis in Children	Completed	NCT02579876	Phase 2	Viaskin Milk 500 mcg;Viaskin Placebo
9	The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy	Completed	NCT00732654	Phase 1, Phase 2	Milk Protein Extract Immunotherapy goal of 4mg/day;Milk Protein Extract Immunotherapy goal of 7mg/day;Milk Powder Immunotherapy goal dose 2000 mg/day;Milk Powder Immunotherapy goal dose 1000mg/day
10	The Effectiveness of Milk Allergy Elimination Through NAET Treatments	Completed	NCT00328731	Phase 1, Phase 2
11	Tolerability to a New Free Amino Acid-based Formula in Children With Cow's Milk Protein Allergy	Completed	NCT02536482	Phase 2
12	Oral Immunotherapy Combined With Humanized Monoclonal Anti-IgE Antibody Xolair® (Omalizumab)in the Treatment of Cow's Milk Allergy	Completed	NCT01157117	Phase 2	Milk powder
13	Dietary Intervention in Milk Allergy and Tolerance Development	Completed	NCT00778258	Phase 2
14	A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy	Completed	NCT00465569	Phase 1, Phase 2	cow's milk powder
15	A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow's Milk Allergy in Children	Completed	NCT02223182	Phase 1, Phase 2
16	A Phase 2 Study to Evaluate the Sensitivity, Specificity and Safety of DBV1605, a Ready-to-Use Atopy Patch Test for the Diagnosis of Non-Immunoglobulin E Mediated Cow's Milk Allergy in Children	Recruiting	NCT04492683	Phase 2
17	A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab and Milk Oral Immunotherapy for the Treatment of Patients With Cow's Milk Allergy	Recruiting	NCT04148352	Phase 2	Dupilumab
18	Phase II Study of Baked Milk Oral Immunotherapy for the Treatment of Cow's Milk Allergy	Active, not recruiting	NCT03462030	Phase 2	Baked non-fat cow's milk powder;Placebo: Tapioca Powder
19	A Prospective Randomized Controlled Trial to Evaluate the Effect of Infant Formula on the Resolution of Cow's Milk Allergy of Infancy	Terminated	NCT02719405	Phase 2
20	Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients	Unknown status	NCT01968278
21	the Value of Serum Esnophilic Cationic Protein as a Diagnostic Parameter in Infants With Cow Milk Protein Allergy	Unknown status	NCT04684329
22	DETERMINATION OF HYPOALLERGENICITY TO SUBSTITUTIVE FORMULAS IN CHILDREN WITH COW'S MILK ALLERGY	Unknown status	NCT02144428
23	Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy	Unknown status	NCT02087930
24	Epigenetic Effects Involved in Children With Cow's Milk Allergy: A Possible Effect of Hypoallergenic Formulas	Unknown status	NCT04184700
25	The Effect of Early Childhood Cow's Milk Allergy Elimination Diet on Eating Behaviors, Nutrition, and Growth Status at Age 2-6	Unknown status	NCT04576845
26	Preventive Effect of Lactobacillus GG on Atopic Manifestation in Children With Cow's Milk Allergy	Unknown status	NCT01891916
27	Cow's Milk and Hen's Egg Hyposensitization in Adults	Unknown status	NCT02083471
28	Mineral Status in Infants With Cow's Milk Protein Allergy Before and After Receiving Amino Acid-based Formula (AAF)	Unknown status	NCT04327297
29	Basophil Activation Test to Diagnose Food Allergy	Unknown status	NCT03309488
30	Comiss Score Fore Detection of Cow's Milk Protein Allergy	Unknown status	NCT03664076
31	Assessment of Cow's Milk-related Symptom Scoring Awareness Tool in Young Turkish Children	Unknown status	NCT03223181
32	Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora	Unknown status	NCT00298376
33	Efficacy of the "Milk Ladder" Intervention in the Development of Tolerance and the Recognition of B Cell Epitopes in Babies Who Are Allergic to Cow's Milk Proteins	Unknown status	NCT03466931
34	Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University	Unknown status	NCT03456479
35	Young Adults With Life Threatening Cow's Milk Allergy: Risks of Decrease Bone Mineralization and Methods of Calcium Supplementation	Unknown status	NCT01930266
36	Cow's Milk Allergy in Infants With Obstructive Sleep Apnea	Unknown status	NCT00659854
37	Tolerability of the New Hypoallergenic Formula in Children With IgE Mediated Cow's Milk Allergy	Unknown status	NCT03909113
38	Dietary Choice for the Management of Cow's Milk Allergy Influences the Acquisition of Oral Tolerance and the Occurrence of Other Allergic Manifestations	Unknown status	NCT03861910
39	The Evaluation of the Effects of an Extensive Casein Hydrolysate Containing the Probiotic Lactobacillus Rhamnosus GG as a Possible Step Down Approach Able to Stimulate the Acquisition of Immunological Tolerance Compared to an Amino Acid Formula in Children Affected by Cow's Milk Protein Allergy	Unknown status	NCT03449537
40	The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy	Completed	NCT01950533
41	Clinical and Biological Description of an Atypical IgE-mediated Cow Milk Allergy (CMA) Form With Hands and Feet Angio-oedema From the Diagnosis to Its Spontaneous Evolution and Comparison to the Typical CMA Form Without Oedema of Extremities	Completed	NCT04318483
42	A Double-blind Randomized Controlled Trial of a Thickened Amino-acid-based Formula in Children Allergic to Cow's Milk and to Protein Hydrolysates	Completed	NCT01940068
43	A Prospective, Randomized, DB Controlled Study to Evaluate the Nutritional Safety (Growth) of an Amino Acid Based Formula With Prebiotics and Probiotics in Infants Diagnosed With Cow Milk Allergy, With or Without Other Food Allergies.	Completed	NCT00664768
44	Effect of Lactobacillus GG on the Appearance of Functional Gastrointestinal Disorders in Children With Cow's Milk Allergy	Completed	NCT01901380
45	Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assiut University Children Hospital	Completed	NCT04330092
46	Symptoms Based Awareness Confirmation Study - CoMiSS Validation	Completed	NCT03004729
47	Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy	Completed	NCT02779881
48	Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy	Completed	NCT01622426
49	A Multicenter, Randomized, Controlled, Cross-over Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy	Completed	NCT02414243
50	Epigenetic Effects Involved in Children With Cow's Milk Allergy: A Possible Effect of Atopic March of Lactobacillus GG (EPICMA)	Completed	NCT02466035

Search NIH Clinical Center for Milk Allergy

Cochrane evidence based reviews: milk hypersensitivity

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Genetic Tests for Milk Allergy

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Anatomical Context for Milk Allergy

Organs/tissues related to Milk Allergy:

MalaCards : Small Intestine, Colon, T Cells, Bone, Skin, Breast, B Cells

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Publications for Milk Allergy

Articles related to Milk Allergy:

(show top 50) (show all 1836)

#	Title	Authors	PMID	Year
1	Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. ⁵³ ⁶²	Savilahti EM...Sampson HA	20462631	2010
2	Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. ⁵³ ⁶²	Wang J...Sampson HA	20226304	2010
3	[Sensitization to casein and beta-lactoglobulin (BLG) in children with cow's milk allergy (CMA)]. ⁵³ ⁶²	Nakano T...Kohno Y	20212353	2010
4	Peptides surviving the simulated gastrointestinal digestion of milk proteins: biological and toxicological implications. ⁵³ ⁶²	Picariello G...Addeo F	19962948	2010
5	Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis. ⁵³ ⁶²	Lee JH...Lee S	20079488	2010
6	Effects of heating and glycation of beta-lactoglobulin on its recognition by IgE of sera from cow milk allergy patients. ⁵³ ⁶²	Taheri-Kafrani A...Haertle T	19489627	2009
7	Eliciting doses of positive challenge test in cow's milk allergy are related to cow's milk specific IgE levels. ⁵³ ⁶²	Garcia-Ara MC...Quirce S	19150029	2008
8	Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. ⁵³ ⁶²	Lam HY...Knulst AC	18384430	2008
9	Usefulness of specific IgE levels in predicting cow's milk allergy. ⁵³ ⁶²	van der Gugten AC...Hoekstra MO	18155280	2008
10	The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. ⁵³ ⁶²	Miceli Sopo S...Calvani M	17651374	2007
11	Sensitization to serum albumins in children allergic to cow's milk and epithelia. ⁵³ ⁶²	Vicente-Serrano J...Moneo I	17680908	2007
12	Maintenance of tolerance to cow's milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. ⁵³ ⁶²	Ruiter B...van Hoffen E	17581206	2007
13	Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. ⁵³ ⁶²	Canani RB...Troncone R	17573720	2007
14	Casein-specific immunoglobulins in cow's milk allergic patient subgroups reveal a shift to IgA dominance in tolerant patients. ⁵³ ⁶²	Sletten GB...Halstensen TS	17295802	2007
15	Memory T cell proliferation in cow's milk allergy after CD25+ regulatory T cell removal suggests a role for casein-specific cellular immunity in IgE-mediated but not in non-IgE-mediated cow's milk allergy. ⁵³ ⁶²	Sletten GB...Halstensen TS	17106206	2007
16	Effect of extensively hydrolyzed milk formula on growth and resistance to bronchitis and atopic dermatitis in infants and toddlers. ⁵³ ⁶²	Estrada-Reyes E...Nava-Ocampo AA	16784012	2006
17	IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients. ⁵³ ⁶²	Suutari TJ...Kokkonen J	17039668	2006
18	Z-score of weight for age of infants with atopic dermatitis and cow's milk allergy fed with a rice-hydrolysate formula during the first two years of life. ⁵³ ⁶²	Savino F...Silvestro L	16214777	2005
19	Human IgE binding to the glycosidic moiety of bovine kappa-casein. ⁵³ ⁶²	Pizzano R...Addeo F	16190658	2005
20	Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. ⁵³ ⁶²	Sicherer SH...Leung DY	15990789	2005
21	Evaluation of the utility of atopy patch testing, skin prick testing, and total and specific IgE assays in the diagnosis of cow's milk allergy. ⁵³ ⁶²	Keskin O...Kalayci O	15945559	2005
22	Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge. ⁵³ ⁶²	Rautava S...Isolauri E	15572894	2004
23	Association between CD62 ligand on naïve and memory T cells and history of cow's milk hypersensitivity in atopic patients. ⁵³ ⁶²	Frieri M...Schaefer P	15191026	2004
24	Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants. ⁵³ ⁶²	Osterlund P...Jarvinen KM	14630983	2004
25	Cow's milk stimulated lymphocyte proliferation and TNFalpha secretion in hypersensitivity to cow's milk protein. ⁵³ ⁶²	Motrich RD...Rivero V	14597219	2003
26	[CD69 and PCNA expression of T-lymphocytes from children with cow's milk allergy (CMA)]. ⁵³ ⁶²	Golebiowska-Wawrzyniak M...Siwinska-Golebiowska H	15213371	2003
27	[Prevalence of soya allergy in children with cow's milk allergy]. ⁵³ ⁶²	Szaflarska-Szczepanik A...Gasiorowska J	12878795	2003
28	Identification of sequential IgE-binding epitopes on bovine alpha(s2)-casein in cow's milk allergic patients. ⁵³ ⁶²	Busse PJ...Sampson HA	12373003	2002
29	Serum immunoglobulin E, IgA, and IgG antibodies to different cow's milk proteins in children with cow's milk allergy: association with prognosis and clinical manifestations. ⁵³ ⁶²	Hidvegi E...Arato A	12390441	2002
30	B-cell epitopes as a screening instrument for persistent cow's milk allergy. ⁵³ ⁶²	Jarvinen KM...Sampson HA	12170271	2002
31	Markers of inflammation in the feces of infants with cow's milk allergy. ⁵³ ⁶²	Saarinen KM...Savilahti E	12144641	2002
32	Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy. ⁵³ ⁶²	Vila L...Sampson HA	11678861	2001
33	IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. ⁵³ ⁶²	Jarvinen KM...Sampson HA	11729348	2001
34	Structure and function of proteins involved in milk allergies. ⁵³ ⁶²	Sharma S...Singh TP	11419710	2001
35	Higher serum eosinophil cationic protein levels in children with cow's milk allergy. ⁵³ ⁶²	Hidvegi E...Arato A	11396817	2001
36	Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy. ⁵³ ⁶²	Saarinen KM...Savilahti E	11260154	2001
37	[Serum eosinophil cationic protein (sECP) level after cow's milk challenge test in allergic children]. ⁵³ ⁶²	Hidvegi E...Arato A	11196237	2000
38	[Study on casein allergy in children]. ⁵³ ⁶²	Hasegawa D...Hoshika A	11193464	2000
39	Does low IgA in human milk predispose the infant to development of cow's milk allergy? ⁵³ ⁶²	Jarvinen KM...Suomalainen HK	11004235	2000
40	Anaphylaxis caused by the unexpected presence of casein in salmon. ⁵³ ⁶²	Koppelman SJ...Knulst AC	10609826	1999
41	Cow's milk casein, a hidden allergen in natural rubber latex gloves. ⁵³ ⁶²	Ylitalo L...Reunala T	10400857	1999
42	In vivo and in vitro studies on the residual allergenicity of partially hydrolysed infant formulae. ⁵³ ⁶²	Niggemann B...Wahn U	10342536	1999
43	Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations. ⁵³ ⁶²	Kapel N...Dupont C	10094375	1999
44	Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine alpha(s)1-casein from the same patients allergic to cow's milk: existence of alpha(s)1-casein-specific B cells and T cells characteristic in cow's-milk allergy. ⁵³ ⁶²	Nakajima-Adachi H...Kaminogawa S	9600504	1998
45	The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity. ⁵³ ⁶²	Hauer AC...MacDonald TT	9357936	1997
46	Monoclonal and polyclonal antibodies against casein components of cow milk for evaluation of residual antigenic activity in 'hypoallergenic' infant formulas. ⁵³ ⁶²	Plebani A...Poiesi C	9291294	1997
47	Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk. ⁵³ ⁶²	Gall H...Sterry W	8648027	1996
48	Establishment and characterization of alpha s1-casein-specific T-cell lines from patients allergic to cow's milk: unexpected higher frequency of CD8+ T-cell lines. ⁵³ ⁶²	Nakajima H...Kaminogawa S	8648031	1996
49	Specific serum IgE in the diagnosis of egg and milk allergy in adults. ⁵³ ⁶²	Norgaard A...Poulsen LK	7503399	1995
50	Evaluation of lymphocyte proliferative responses to casein hydrolysate formula in cow's milk-sensitive children: response of peripheral blood mononuclear cells to hydrolysate formula. ⁵³ ⁶²	Nishida T...Orii T	7655706	1995

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Genes for Milk Allergy

Genes related to Milk Allergy (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CSN1S1	Casein Alpha S1	Protein Coding	27.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20212353 10400857 11193464 (more) 9291294 2007924 8648031 11419710 17106206 1444835 7655706 20079488 18384430 16214777 16784012 10609826 12373003 19962948 7978534 7532192
2	LALBA	Lactalbumin Alpha	Protein Coding	26.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11419710 8648027 12170271 (more) 16784012 11729348
3	CSN3	Casein Kappa	Protein Coding	25.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12170271
4	CSN2	Casein Beta	Protein Coding	23.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11678861
5	RNASE3	Ribonuclease A Family Member 3	Protein Coding	20.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12144641 10094375 11396817 (more) 14630983 11196237 11260154
6	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	17.66	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20226304 11729348 2310057 (more) 11260154 11678861 19489627 20462631 2025004 17573720 18155280 8448679 14760265 12878795 9600504 17651374 16190658 14597219 17581206 17295802 16784012 17039668 19150029 7503399 7526967 10342536 7978534 17680908 15990789 10094375
7	CD69	CD69 Molecule	Protein Coding	14.92	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15213371 15191026
8	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	14.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15572894
9	CD79A	CD79a Molecule	Protein Coding	14.17	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11004235 12144641 1809019 (more) 17295802 12390441 20462631
10	IL4	Interleukin 4	Protein Coding	13.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9357936 15945559 15572894
11	IGES	Immunoglobulin E Concentration, Serum	Genetic Locus	13.12	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12390441
12	IL5	Interleukin 5	Protein Coding	11.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9357936
13	IL13	Interleukin 13	Protein Coding	11.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15557695
14	PEDS1	Plasmanylethanolamine Desaturase 1	Protein Coding	8.18	DISEASES inferred ¹⁴
15	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.4	DISEASES inferred ¹⁴ ¹⁴
16	EHF	ETS Homologous Factor	Protein Coding	7.18	DISEASES inferred ¹⁴
17	FOXP3	Forkhead Box P3	Protein Coding	6.89	DISEASES inferred ¹⁴
18	IL10	Interleukin 10	Protein Coding	6.77	DISEASES inferred ¹⁴
19	CD4	CD4 Molecule	Protein Coding	6.36	DISEASES inferred ¹⁴
20	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	6.3	DISEASES inferred ¹⁴

Sources

Variations for Milk Allergy

Sources

Expression for Milk Allergy

Search GEO for disease gene expression data for Milk Allergy.

Sources

Pathways for Milk Allergy

Pathways related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.3	TGFB2 IL5 IL4 IL13 IL10 CD4
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.17	TGFB2 IL5 IL4 IL13 IL10 CD4
3	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.53	TGFB2 IL5 IL4 IL13 IL10
4	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.03	IL5 IL4 IL10 CD4
5	Neuroinflammation and glutamatergic signaling ⁷⁴	11.98	TGFB2 IL4 IL13 IL10
6	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.91	CD4 CD69 CD79A IL10 IL4 IL5
7	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.84	IL4 IL13 IL10
8	Allograft rejection ⁷⁴	11.82	IL5 IL4 IL13 IL10 FOXP3
9	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.75	TGFB2 IL4 CD4
10	Glucocorticoid receptor regulatory network ⁶¹	11.7	CSN2 IL13 IL4 IL5
11	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.65	IL4 IL10 CD79A CD69
12	AP-1 transcription factor network ⁶¹	11.61	IL10 IL4 IL5
13	Th17 cell differentiation pathway ⁷⁴	11.61	CD4 FOXP3 IL4
14	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.59	IL5 IL4 FOXP3
15	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.57	IL5 IL4 IL13 IL10 FOXP3
16	Lung fibrosis ⁷⁴	11.55	IL5 IL4 IL13
17	IL4-mediated signaling events ⁶¹	11.52	IL5 IL4 IL10
18	Development and heterogeneity of the ILC family ⁷⁴	11.28	TSLP IL5 IL4 IL13
19	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.26	TGFB2 IL10 FOXP3
20	OX40 Pathway ⁶⁴	11.15	IL5 IL4 IL13 IL10
21	Cytokines and inflammatory response ⁷⁴	11.12	IL5 IL4 IL13 IL10 CD4
22	Th2 Differentiation ⁶⁵	11.1	IL5 IL4 IL13 IL10 FOXP3 CD4
23	Innate Lymphoid Cells Differentiation ⁶⁵	11.07	TSLP IL5 IL4 IL13 IL10 CD4
24	Immune infiltration in pancreatic cancer ⁷⁴	10.99	TGFB2 IL5 IL4 IL13 IL10
25	G-protein signaling_Rap2B regulation pathway ²²	10.91	TGFB2 IL5 IL4 IL13 IL10
26	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.8	IL4 CD4
27	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.7	TGFB2 IL5 IL4 IL13

Sources

GO Terms for Milk Allergy

Cellular components related to Milk Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.02	CSN1S1 CSN2 CSN3 IGHE IL10 IL13
2	external side of plasma membrane	GO:0009897	9.93	IL13 IGHE CD79A CD69 CD4 CCR6
3	extracellular space	GO:0005615	9.7	TSLP TGFB2 RNASE3 LALBA IL5 IL4

Biological processes related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of B cell proliferation	GO:0030890	9.95	IL5 IL4 IL13
2	negative regulation of inflammatory response	GO:0050728	9.95	IL4 IL13 IL10 FOXP3
3	positive regulation of interleukin-10 production	GO:0032733	9.91	TSLP IL4 IL13
4	type 2 immune response	GO:0042092	9.8	IL4 IL10
5	negative regulation of endothelial cell apoptotic process	GO:2000352	9.73	IL4 IL13 IL10
6	negative regulation of chronic inflammatory response	GO:0002677	9.67	FOXP3 IL4
7	regulation of isotype switching	GO:0045191	9.62	IL10 IL4
8	regulation of complement-dependent cytotoxicity	GO:1903659	9.46	TGFB2 IL10
9	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.46	IL4 IL13
10	immune response	GO:0006955	9.44	IL5 IL4 IL13 IL10 IGHE CD4
11	positive regulation of immunoglobulin production	GO:0002639	9.43	IL5 IL13 IL10

Molecular functions related to Milk Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.4	TSLP TGFB2 IL5 IL4 IL13 IL10

Sources

Sources for Milk Allergy

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MLK006 MIFTS: 45	Milk Allergy Categories: Gastrointestinal diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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