Aliases & Classifications for Milk Allergy

MalaCards integrated aliases for Milk Allergy:

Name: Milk Allergy 12 15
Milk Hypersensitivity 44 73
Milk Allergic Reaction 12
Allergy Milk 55


External Ids:

Disease Ontology 12 DOID:4376
MeSH 44 D016269
UMLS 73 C0079840

Summaries for Milk Allergy

Disease Ontology : 12 A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

MalaCards based summary : Milk Allergy, also known as milk hypersensitivity, is related to goat milk allergy and cow milk allergy. An important gene associated with Milk Allergy is CD79A (CD79a Molecule), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Soy Bean and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and small intestine, and related phenotype is endocrine/exocrine gland.

Wikipedia : 76 Milk allergy is an adverse immune reaction to one or more proteins in cow\'s milk. When allergy symptoms... more...

Related Diseases for Milk Allergy

Diseases related to Milk Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 goat milk allergy 34.8 CSN1S1 LALBA
2 cow milk allergy 32.5 CD79A IL10 IL5 RNASE3
3 eosinophilic gastroenteritis 29.8 IL5 RNASE3
4 sinusitis 29.4 IL5 RNASE3
5 egg allergy 29.3 IL4 IL5
6 dermatitis 28.9 IL4 IL5 RNASE3
7 tetanus 28.2 CD79A IL10 IL4 IL5
8 gastroenteritis 28.2 IL10 IL4 IL5 RNASE3
9 dermatitis, atopic 27.9 CSN1S1 IL10 IL4 IL5 RNASE3
10 asthma 27.1 CD79A IL10 IL4 IL5 RNASE3
11 lactose intolerance 11.3
12 heiner syndrome 11.1
13 sporotrichosis 10.6 CD79A IL10
14 mycetoma 10.6 CSN1S1 IL10
15 chronic graft versus host disease 10.6 CD79A IL10
16 clonorchiasis 10.6 CD79A IL10
17 chronic interstitial cystitis 10.5 CD79A RNASE3
18 anisakiasis 10.5 CD79A RNASE3
19 maxillary sinusitis 10.5 CD79A RNASE3
20 tuberculoid leprosy 10.4 IL10 TGFB2
21 lipid-rich carcinoma 10.4 CSN2 LALBA
22 lipoid nephrosis 10.4 CD79A IL10
23 henoch-schoenlein purpura 10.4 CD79A RNASE3
24 tropical endomyocardial fibrosis 10.4 IL10 IL4
25 collagenous colitis 10.4 CD79A RNASE3
26 hyperlucent lung 10.4 IL10 IL4
27 tungiasis 10.4 IL10 IL4
28 endomyocardial fibrosis 10.3 IL10 IL4
29 retinitis pigmentosa 22 10.3 IL10 IL4
30 baylisascariasis 10.3 IL10 IL4
31 q fever 10.3 CD79A IL10
32 chronic maxillary sinusitis 10.3 CD79A RNASE3
33 beta-lactam allergy 10.3 IL10 IL4
34 congenital hypogammaglobulinemia 10.3 CD79A IL4
35 parasitic ichthyosporea infectious disease 10.3 CD79A IL4
36 rhinosporidiosis 10.3 CD79A IL4
37 buruli ulcer 10.3 IL10 IL4
38 primary systemic mycosis 10.3 IL10 IL4
39 immunodeficiency with hyper-igm, type 1 10.3 CD79A IL4
40 poliomyelitis 10.2 IL10 IL4
41 blepharoconjunctivitis 10.2 IL4 RNASE3
42 microscopic colitis 10.2 CD79A IL4
43 bardet-biedl syndrome 15 10.2 IL10 IL4
44 giant papillary conjunctivitis 10.2 IL4 RNASE3
45 celiac disease 1 10.2 CD79A IL10 LALBA
46 eales disease 10.2 IL10 IL4
47 vulvovaginal candidiasis 10.2 CD79A IL4
48 genital herpes 10.2 IL10 IL4
49 mastitis 10.2 CSN2 CSN3 LALBA
50 lichen disease 10.1 CD79A IL4

Graphical network of the top 20 diseases related to Milk Allergy:

Diseases related to Milk Allergy

Symptoms & Phenotypes for Milk Allergy

MGI Mouse Phenotypes related to Milk Allergy:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CSN2 CSN3 IL10 IL4 LALBA TGFB2

Drugs & Therapeutics for Milk Allergy

Drugs for Milk Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Soy Bean Nutraceutical Phase 4,Not Applicable
Omalizumab Approved, Investigational Phase 2,Early Phase 1 242138-07-4
3 Chelating Agents Phase 2,Not Applicable
4 Vaccines Phase 2,Not Applicable
5 Caseins Phase 2,Not Applicable
6 Respiratory System Agents Phase 2,Early Phase 1
7 Anti-Allergic Agents Phase 2,Early Phase 1
8 Anti-Asthmatic Agents Phase 2,Early Phase 1
9 Immunoglobulin E Phase 1, Phase 2,Phase 2,Not Applicable
10 Antibodies Phase 2,Phase 1,Not Applicable
11 Immunoglobulins Phase 2,Phase 1,Not Applicable
12 Antibodies, Monoclonal Phase 2
13 Acidophilus Nutraceutical Phase 2,Not Applicable
14 Whey Protein Nutraceutical Phase 2,Not Applicable
Calcium Carbonate Approved, Investigational Not Applicable 471-34-1
Menthol Approved Not Applicable 2216-51-5 16666
Menadione Approved, Nutraceutical Not Applicable 58-27-5 4055
Phytonadione Approved, Investigational, Nutraceutical Not Applicable 84-80-0 4812 5284607
19 Calcium, Dietary Not Applicable
20 Micronutrients Not Applicable
21 Coagulants Not Applicable
22 Complement System Proteins Not Applicable
23 Hemostatics Not Applicable
24 Dermatologic Agents
25 Trace Elements Not Applicable
26 Vitamin K 2 Not Applicable
27 Vitamin MK 7 Not Applicable
28 Vitamins Not Applicable
29 Antifibrinolytic Agents Not Applicable
30 naphthoquinone Nutraceutical Not Applicable
31 Vitamin K Nutraceutical Not Applicable
32 Flax Nutraceutical Not Applicable
33 Menaquinone Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 94)
# Name Status NCT ID Phase Drugs
1 Growth, Safety and Tolerance of a Rice Protein Hydrolysate Formula in Infants With Cow's Milk Protein Allergy Unknown status NCT02405923 Phase 4
2 Safety of Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
3 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Recruiting NCT01966640 Phase 4
4 Parmigiano-Reggiano Cheese as a Possible Strategy to Acquire Oral Tolerance in Children With Cow's Milk Allergy Unknown status NCT02081651 Phase 3
5 Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy Completed NCT02351531 Phase 3
6 Evaluation of the Hypoallergenicity of an Extensively Hydrolyzed Formula Completed NCT02711163 Phase 3
7 Improving the Safety of Oral Immunotherapy in Cow's Milk Allergy Not yet recruiting NCT02216175 Phase 2, Phase 3
8 Epigenetic Effects Elicited By Lactobacillus GG In Children With Cow's Milk Allergy Unknown status NCT02062476 Phase 2
9 Evaluation of the Efficacy of a New Infant Formula in Subjects With Cow's Milk Allergy Unknown status NCT02149134 Phase 2
10 Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy Unknown status NCT02414243 Phase 2
11 Therapeutic Effect of Chinese Herbal Medicine on Food Allergy Unknown status NCT00602160 Phase 2 FAHF-2 (TM)
12 Milk ALLERGY ELIMINATION THROUGH NAET® (Nambudripad's Allergy Elimination Techniques). Completed NCT00328731 Phase 1, Phase 2
13 The Effect of Baked Milk on Cow's Milk Allergy Completed NCT02738060 Phase 2
14 OIT and Xolair® (Omalizumab) in Cow's Milk Allergy Completed NCT01157117 Phase 2 Milk powder
15 Study of Milk Allergy and Tolerance in Children Completed NCT00778258 Phase 2
16 A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy Completed NCT00465569 Phase 1, Phase 2 cow's milk powder
17 Free Amino Acid-based Formula to Treat Children Cow's Milk Protein Allergy Completed NCT02536482 Phase 2
18 The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy Completed NCT00732654 Phase 1, Phase 2 Milk Protein Extract Immunotherapy goal of 4mg/day;Milk Protein Extract Immunotherapy goal of 7mg/day;Milk Powder Immunotherapy goal dose 2000 mg/day;Milk Powder Immunotherapy goal dose 1000mg/day
19 Tolerance of Infants With Cow's Milk Protein Allergy to Extensively Hydrolyzed Rice Protein or Casein Infant Formulas Completed NCT01909661 Phase 2
20 A Clinical Study to Investigate the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth, Safety and Tolerance in Healthy Term Infants Recruiting NCT03062761 Phase 2
21 Efficacy and Safety of Viaskin Milk in Children With IgE-Mediated Cow's Milk Allergy Active, not recruiting NCT02223182 Phase 1, Phase 2
22 Milk Patch for Eosinophilic Esophagitis Active, not recruiting NCT02579876 Phase 2 Viaskin Milk 500 mcg;Viaskin Placebo
23 Food Allergen OIT for Shrimp, Milk or Cashew Not yet recruiting NCT03504774 Phase 2
24 Impact of Infant Formula on Resolution of Cow's Milk Allergy Terminated NCT02719405 Phase 2
25 Baked Milk Oral Immunotherapy for Cow's Milk Allergy Enrolling by invitation NCT03462030 Phase 1 Baked non-fat cow's milk powder;Placebo: Tapioca Powder
26 Hypoallergenicity To Substitutive Formulas In Children With Cow's Milk Allergy Unknown status NCT02144428
27 Oral Tolerance in Cow’s Milk Allergy in the Infant Unknown status NCT00298376
28 Cow's Milk Allergy in Infants With Obstructive Sleep Apnea (OSA) Unknown status NCT00659854 Not Applicable
29 Effect Of Lactobacillus GG on Atopic March Unknown status NCT01891916 Not Applicable
30 Nutrition in Children With Food Allergy Unknown status NCT01583907
31 Young Adults With Life Threatening Cow's Milk Allergy: Risks of Decrease Bone Mineralization and Methods of Calcium Supplementation Unknown status NCT01930266 Not Applicable
32 Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients Unknown status NCT01968278 Not Applicable
33 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471 Not Applicable
34 The Influence of Probiotics on the Immunologic Response to Vaccinations in Infants Unknown status NCT00645996 Not Applicable
35 Epigenetic Effects Involved in Children With Cow's Milk Allergy (EPICMA) Completed NCT02466035 Not Applicable
36 Prevention of Cow's Milk Allergy in Children Completed NCT00792090 Not Applicable
37 Effect of Therapy With Aminoacid Based Formula Versus Hydrolyzed Whey Proteins in Children With Cow's Milk Allergy Completed NCT02379598
38 Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy Completed NCT01622426 Not Applicable
39 A Growth and Hypoallergenicity Study of a New Formula for Infants With Cow Milk Allergy Completed NCT00664768 Not Applicable
40 Cow's Milk Allergy and Functional Gastrointestinal Disorders Completed NCT01901380
41 Oral Immunotherapy in Cow's Milk Allergy (CMA) in Children : "Petit Lait" Study Completed NCT02465905 Not Applicable
42 Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy Completed NCT02779881
43 Effects of Different Dietary Regimens on Tolerance Acquisition in Children With Cow's Milk Allergy Completed NCT01634490
44 An Interventional Study of Milk Allergy Completed NCT00578656 Early Phase 1
45 Camel's Milk as a Safe Alternative in Cow's Milk Allergy Completed NCT01223885 Not Applicable
46 Formula for Children With Cow's Milk Allergy Completed NCT02317952 Not Applicable
47 Tolerability and Safety of An Infant Formula Completed NCT00938483 Not Applicable
48 Specific Oral Tolerance Induction to Cow's Milk Allergy Completed NCT01199484 Not Applicable
49 Polymerized Beta-lactoglobulin Comparative Immunoreactivity Completed NCT01589731
50 Isomil Post Marketing Observational Study Completed NCT01809951

Search NIH Clinical Center for Milk Allergy

Cochrane evidence based reviews: milk hypersensitivity

Genetic Tests for Milk Allergy

Anatomical Context for Milk Allergy

MalaCards organs/tissues related to Milk Allergy:

Testes, Colon, Small Intestine, T Cells, B Cells, Bone, Skin

Publications for Milk Allergy

Articles related to Milk Allergy:

(show top 50) (show all 222)
# Title Authors Year
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
Nutritional management of cow's milk allergy in children: An update. ( 29576253 )
The global impact of the DRACMA guidelines cow's milk allergy clinical practice. ( 29308116 )
A Case of Work-Related Donkey Milk Allergy. ( 29939141 )
Brazilian artisanal ripened cheeses as sources of proteolytic lactic acid bacteria capable of reducing cow milk allergy. ( 29654625 )
Correction to: Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. ( 29416848 )
Elevated serum adipsin may predict unsuccessful treatment for cows' milk allergy but other biomarkers do not. ( 29028118 )
Tolerability and palatability of donkey's milk in children with cow's milk allergy. ( 29392769 )
CD300c co-stimulates IgE-mediated basophils activation and its expression is increased in cowA's milk allergy. ( 29906528 )
Children with cow's milk allergy following an elimination diet had normal growth but relatively low plasma leptin at age two. ( 29461665 )
Shift from IgE-mediated cow's milk allergy to food protein induced enterocolitis syndrome in two infants. ( 29444343 )
Component resolved diagnostic study of cow's milk allergy in infants and young children in northern China. ( 29859469 )
Hypoallergenic casein hydrolysate for peptide-based oral immunotherapy in cow's milk allergy. ( 29704594 )
Randomized Trial of a Yogurt-type Amino Acid-based Formula in Infants and Children With Severe Cow's Milk Allergy. ( 29095347 )
Iberian consensus on cow's milk allergy: The CIBAL Study. ( 29477244 )
Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study. ( 29393170 )
Bodybuilding protein supplements and cow's milk allergy in adult. ( 29350021 )
Basophil activation test in a case report of cow's milk allergy may reveal a non-IgE mediated mechanism. ( 29369413 )
Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients. ( 29408543 )
PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention. ( 29079360 )
Natural history of immunoglobulin E-mediated cow's milk allergy in a population of Argentine children. ( 28737860 )
Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial. ( 29234055 )
Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review. ( 28516451 )
Evidence for Involvement of IL-9 and IL-22 in Cows' Milk Allergy in Infants. ( 28934137 )
Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy. ( 28414061 )
Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants. ( 28698533 )
The Efficacy of Oral Immunotherapy in Patients with Cow's Milk Allergy. ( 28732431 )
Gastrointestinal Symptoms of Food Challenge-Proven Non-Ige Cow's Milk Allergy are Dissipated by Early School Age. ( 28922259 )
Immunotherapy for cow's milk allergy. ( 28825866 )
Is a slow-progression baked milk protocol of oral immunotherapy always a safe option for children with cow's milk allergy? A randomized controlled trial. ( 28875570 )
Preventive effects of royal jelly against anaphylactic response in a murine model of cow's milk allergy. ( 28982287 )
Altered miR-193a-5p expression in children with cow's milk allergy. ( 28857182 )
Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited. ( 29270244 )
Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells. ( 29033945 )
Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy. ( 29149860 )
Prognostic accuracy of clinical signs and diagnostic tests in cow's milk allergy in newborns. ( 28416249 )
Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization. ( 27826960 )
Accuracy of serum IgE concentrations and papule diameter in the diagnosis of cow's milk allergy. ( 28963879 )
Long-term outcomes following baked milk-containing diet for IgE-mediated milk allergy. ( 28583481 )
A History of Cow's Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren. ( 28715821 )
Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. ( 28852472 )
Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy. ( 28597347 )
Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study. ( 28459985 )
Association between Caesarean Delivery and Isolated Doses of Formula Feeding in Cow Milk Allergy. ( 28787733 )
An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care. ( 28948011 )
Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy. ( 29031891 )
Cost-effectiveness of using an extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in the US. ( 29098889 )
Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age. ( 28720381 )
Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies. ( 28679035 )
Cow's milk allergy: Evaluating tolerance through skin-prick test. ( 27849231 )

Variations for Milk Allergy

Expression for Milk Allergy

Search GEO for disease gene expression data for Milk Allergy.

Pathways for Milk Allergy

Pathways related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.57 IL10 IL4 IL5 RNASE3
Show member pathways
12.12 IL10 IL4 IL5
Show member pathways
12.09 IL10 IL4 IL5 TGFB2
Show member pathways
11.93 IL10 IL4 TGFB2
Show member pathways
11.77 IL10 IL4 IL5 TGFB2
6 11.52 CSN2 IL4 IL5
7 11.48 IL10 IL4 IL5
8 11.3 IL10 IL4 IL5
9 11.1 IL10 IL4 IL5
10 11.03 IL4 IL5
11 11 IL4 IL5
12 10.99 CD79A IL10 IL4 IL5
13 10.81 IL10 IL4 IL5
14 10.55 IL10 IL4 IL5

GO Terms for Milk Allergy

Cellular components related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CSN1S1 CSN2 CSN3 IL10 IL4 IL5
2 extracellular space GO:0005615 9.28 CSN1S1 CSN2 CSN3 IL10 IL4 IL5

Biological processes related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 IL10 IL4 IL5 TGFB2
2 defense response to bacterium GO:0042742 9.63 IL10 LALBA RNASE3
3 lactation GO:0007595 9.54 CSN2 CSN3
4 response to progesterone GO:0032570 9.52 CSN1S1 TGFB2
5 positive regulation of B cell proliferation GO:0030890 9.51 IL4 IL5
6 positive regulation of cell cycle GO:0045787 9.49 IL10 TGFB2
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL10 IL4
8 B cell proliferation GO:0042100 9.43 CD79A IL10
9 B cell differentiation GO:0030183 9.43 CD79A IL10 IL4
10 B cell activation GO:0042113 9.4 CD79A IL4
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
12 type 2 immune response GO:0042092 9.16 IL10 IL4
13 regulation of isotype switching GO:0045191 8.96 IL10 IL4
14 regulation of complement-dependent cytotoxicity GO:1903659 8.62 IL10 TGFB2

Molecular functions related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL10 IL4 IL5 TGFB2
2 growth factor activity GO:0008083 8.92 IL10 IL4 IL5 TGFB2

Sources for Milk Allergy

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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