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MCID: MLK001
MIFTS: 31

Milker's Nodule

Categories: Infectious diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Milker's Nodule

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MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule 12 15 17
Poxviridae Infections 45 74
Milker's Nodes 74
Milker Nodule 12
Milkers' Node 12
Paravaccinia 12
Pseudocowpox 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8729
ICD9CM 36 051.1 051.9
MeSH 45 D011213
SNOMED-CT 69 27240009
ICD10 34 B08.04
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Summaries for Milker's Nodule

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Disease Ontology : 12 A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in_formation_of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and cowpox, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is TNFRSF8 (TNF Receptor Superfamily Member 8). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and liver.

Wikipedia : 77 Milker''s nodules (or "milkmaid blisters") are a cutaneous condition that is most commonly transmitted... more...

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Related Diseases for Milker's Nodule

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Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 10.1
2 cowpox 10.1
3 stomatitis 10.1
4 myeloma, multiple 10.1
5 graft-versus-host disease 10.1
6 hematopoietic stem cell transplantation 10.1
7 gianotti crosti syndrome 10.1
8 ecthyma 10.0
9 diarrhea 10.0
10 vulvovaginitis 10.0
11 vaccinia 10.0

Graphical network of the top 20 diseases related to Milker's Nodule:



Diseases related to Milker's Nodule
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Symptoms & Phenotypes for Milker's Nodule

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Symptoms:

12
  • • fever
  • • lymphadenopathy
  • • lymphangitis
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Drugs & Therapeutics for Milker's Nodule

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Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
4 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2,Phase 1
5 gamma-Globulins Phase 4,Phase 3,Phase 2,Phase 1
6 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2,Phase 1
7 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
8
Sorafenib Approved, Investigational Phase 3,Phase 2 284461-73-0 216239 406563
9
Cantharidin Approved, Investigational Phase 3,Phase 2,Not Applicable 56-25-7
10 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Phase 1
11 Protein Kinase Inhibitors Phase 3,Phase 2
12 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2
13 Iron-Dextran Complex Phase 3
14
Sargramostim Approved, Investigational Phase 2,Phase 1 123774-72-1, 83869-56-1
15
Phenol Approved, Experimental Phase 2 108-95-2 996
16
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 6857599 5310940 9887054 43805
17
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
18
Irinotecan Approved, Investigational Phase 1, Phase 2 100286-90-6, 97682-44-5 60838
19
Bicalutamide Approved Phase 2 90357-06-5 2375 56069
20
Metronidazole Approved Phase 2,Phase 1 443-48-1 4173
21
Goserelin Approved Phase 2 65807-02-5 5311128 47725
22
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
23 Liver Extracts Phase 2,Phase 1
24 Immunoglobulin G Phase 2,Phase 1
25 Cola Phase 1, Phase 2,Phase 2
26 Topoisomerase Inhibitors Phase 1, Phase 2
27 topoisomerase I inhibitors Phase 1, Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Antiparasitic Agents Phase 2,Phase 1
30 Hormone Antagonists Phase 2
31 Androgen Antagonists Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
33 Antiprotozoal Agents Phase 2,Phase 1
34 Hormones Phase 2
35 Anti-Infective Agents Phase 2,Phase 1
36 Androgens Phase 2
37 Anti-Bacterial Agents Phase 2,Phase 1
38 Angiogenesis Modulating Agents Phase 1, Phase 2
39 Antineoplastic Agents, Immunological Phase 1, Phase 2
40
Cisplatin Approved Phase 1 15663-27-1 441203 84093 2767
41
Cemiplimab Approved, Investigational Phase 1 1801342-60-8
42
Lactitol Investigational Phase 1 585-86-4, 585-88-6 493591
43 Adjuvants, Immunologic Phase 1
44 MF59 oil emulsion Phase 1
45 Laxatives Phase 1
46 Poly ICLC Phase 1
47 Cathartics Phase 1
48 Gastrointestinal Agents Phase 1
49 interferons Phase 1
50 Antiviral Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 121)
# Name Status NCT ID Phase Drugs
1 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
2 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3 tecovirimat
3 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3 smallpox vaccine CJ-50300
4 VA-006 Vaccinia Vaccine (ACAM2000) for the Production of VIGIV Completed NCT01158157 Phase 3
5 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
6 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3 smallpox vaccine CJ-50300
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
9 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
10 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
11 Hepatocellular Carcinoma Study Comparing Vaccinia Virus Based Immunotherapy Plus Sorafenib vs Sorafenib Alone Recruiting NCT02562755 Phase 3 Sorafenib
12 Cantharidin Application in Molluscum Patients Active, not recruiting NCT03377803 Phase 3 VP-102;Placebo
13 Cantharidin Application in Molluscum Patients-1 Active, not recruiting NCT03377790 Phase 3 VP-102;Placebo
14 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
15 Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial Not yet recruiting NCT03699124 Phase 3
16 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
17 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
18 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
19 Safety and Immunogenicity Study of AIDS Vaccine (Combined Use of DNA Vaccine and Recombinant Vaccinia Virus Tiantan) Completed NCT01705223 Phase 2
20 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
21 A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer Completed NCT01636284 Phase 2
22 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
23 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2 Placebo
24 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
25 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
26 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2 MVA Smallpox vaccine;Placebo
27 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2 Placebo (subcutaneous);Placebo (scarification)
28 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNEâ„¢) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
29 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
30 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
31 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
32 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
33 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
34 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
35 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
36 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
37 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
38 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
39 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
40 A Study to Evaluate the Safety and Efficacy of SB206 in Subjects With Molluscum Contagiosum Completed NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
41 Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum. Completed NCT03186378 Phase 2 VP-102
42 A Study of VBP-245 in Pediatric Patients With Molluscum Contagiosum Completed NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
43 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
44 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
45 A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis Completed NCT01443260 Phase 1, Phase 2
46 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Completed NCT02038881 Phase 2
47 Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma Completed NCT01394939 Phase 1, Phase 2 Irinotecan
48 A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib Completed NCT01387555 Phase 2
49 A Study of Recombinant Vaccinia Virus Prior to Sorafenib to Treat Unresectable Primary Hepatocellular Carcinoma Completed NCT01171651 Phase 2 JX-594 followed by sorafenib
50 A Study of Recombinant Vaccinia Virus to Treat Unresectable Primary Hepatocellular Carcinoma Completed NCT00554372 Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

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Genetic Tests for Milker's Nodule

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Anatomical Context for Milker's Nodule

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The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

20
Skin

MalaCards organs/tissues related to Milker's Nodule:

42
Skin, Liver, Prostate, Eye, T Cells, B Cells, Testis
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Publications for Milker's Nodule

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Articles related to Milker's Nodule:

# Title Authors Year
1
Dermoscopic features and types of orf and milker's nodule. ( 28951712 )
2017
2
Milker's nodule: an occupational infection and threat to the immunocompromised. ( 29125649 )
2017
3
Milker's nodule--Case report. ( 26131876 )
2015
4
Milker's nodule--case report. ( 17631788 )
2007
5
Milker's nodule in a healthy young woman. ( 14576676 )
2003
6
Milker's nodule--a report of 15 cases in the county of North Jutland. ( 8721513 )
1996
7
Bullous eruption complicating a milker's nodule. ( 2834299 )
1988
8
Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. ( 4317817 )
1970
9
Milker's nodule. A clinical and electron microscopic report. ( 4313268 )
1970
10
Milker's nodule virus infections in Dorset and their similarity to orf. ( 4286392 )
1965
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Variations for Milker's Nodule

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Expression for Milker's Nodule

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Search GEO for disease gene expression data for Milker's Nodule.
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Pathways for Milker's Nodule

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GO Terms for Milker's Nodule

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Sources for Milker's Nodule

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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