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MCID: MLK001
MIFTS: 31

Milker's Nodule

Categories: Infectious diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Milker's Nodule

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MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule 12 15
Poxviridae Infections 44 73
Milker's Nodes 73
Milker Nodule 12
Milkers' Node 12
Paravaccinia 12
Pseudocowpox 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8729
ICD10 33 B08.04
ICD9CM 35 051.1 051.9
MeSH 44 D011213
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Summaries for Milker's Nodule

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Disease Ontology : 12 A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in_formation_of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to myeloma, multiple and graft-versus-host disease, and has symptoms including fever, lymphangitis and lymphadenopathy. An important gene associated with Milker's Nodule is TNFRSF8 (TNF Receptor Superfamily Member 8). The drugs Vaccines and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and liver.

Wikipedia : 76 Milker\'s nodules (or \"milkmaid blisters\") are a cutaneous condition that is most commonly transmitted... more...

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Related Diseases for Milker's Nodule

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Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 9.9
2 graft-versus-host disease 9.9
3 hematopoietic stem cell transplantation 9.9
4 erythema multiforme 9.9
5 cowpox 9.9
6 gianotti crosti syndrome 9.9
7 ecthyma 9.9
8 vulvovaginitis 9.9
9 stomatitis 9.9

Graphical network of the top 20 diseases related to Milker's Nodule:



Diseases related to Milker's Nodule
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Symptoms & Phenotypes for Milker's Nodule

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Symptoms:

12
  • • fever
  • • lymphangitis
  • • lymphadenopathy
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Drugs & Therapeutics for Milker's Nodule

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Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
3 gamma-Globulins Phase 4,Phase 2,Phase 1
4 Antibodies Phase 4,Phase 2,Phase 1
5 Immunoglobulins Phase 4,Phase 2,Phase 1
6 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
7
Sorafenib Approved, Investigational Phase 3,Phase 2 284461-73-0 216239 406563
8
Cantharidin Approved, Investigational Phase 3,Phase 2,Not Applicable 56-25-7
9
Nicotinamide Approved, Investigational, Nutraceutical Phase 3,Phase 2 98-92-0 936
10
Niacin Approved, Investigational, Nutraceutical Phase 3,Phase 2 59-67-6 938
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
12 Micronutrients Phase 3,Phase 2
13 Nicotinic Acids Phase 3,Phase 2
14 Trace Elements Phase 3,Phase 2
15 Vitamin B Complex Phase 3,Phase 2
16 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Phase 1
17 Vitamins Phase 3,Phase 2
18 Protein Kinase Inhibitors Phase 3,Phase 2
19 Angiogenesis Inhibitors Phase 3
20 Folate Nutraceutical Phase 3,Phase 2
21 Vitamin B3 Nutraceutical Phase 3,Phase 2
22 Vitamin B9 Nutraceutical Phase 3,Phase 2
23
Phenol Approved, Experimental Phase 2 108-95-2 996
24
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
25
Metronidazole Approved Phase 2,Phase 1 443-48-1 4173
26
Goserelin Approved Phase 2 65807-02-5 47725 5311128
27
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 43805 6857599
28
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
29
Bicalutamide Approved Phase 2 90357-06-5 56069 2375
30
Camptothecin Experimental Phase 1, Phase 2 7689-03-4
31 topoisomerase I inhibitors Phase 1, Phase 2
32 Androgen Antagonists Phase 2
33 Androgens Phase 2
34 Topoisomerase Inhibitors Phase 1, Phase 2
35 Hormone Antagonists Phase 2
36 Hormones Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
38 Anti-Infective Agents Phase 2,Phase 1
39 Antiparasitic Agents Phase 2,Phase 1
40 Liver Extracts Phase 2,Phase 1
41 Antiprotozoal Agents Phase 2,Phase 1
42 Antineoplastic Agents, Hormonal Phase 2
43 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
44 Cola Nutraceutical Phase 1, Phase 2,Phase 2
45
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
46
Lactitol Investigational Phase 1 585-86-4 3871
47 Adjuvants, Immunologic Phase 1
48 MF59 oil emulsion Phase 1
49 interferons Phase 1
50 Cathartics Phase 1

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
2 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
3 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3 tecovirimat
4 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3 smallpox vaccine CJ-50300
5 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
6 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3 smallpox vaccine CJ-50300
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
9 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
10 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
11 Cantharidin Application in Molluscum Patients Recruiting NCT03377803 Phase 3 VP-102;Placebo
12 Cantharidin Application in Molluscum Patients-1 Recruiting NCT03377790 Phase 3 VP-102;Placebo
13 Hepatocellular Carcinoma Study Comparing Vaccinia Virus Based Immunotherapy Plus Sorafenib vs Sorafenib Alone Recruiting NCT02562755 Phase 3 Sorafenib
14 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
15 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
16 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
17 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
18 Safety and Immunogenicity Study of AIDS Vaccine (Combined Use of DNA Vaccine and Recombinant Vaccinia Virus Tiantan) Completed NCT01705223 Phase 2
19 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
20 A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer Completed NCT01636284 Phase 2
21 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
22 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2 Placebo
23 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
24 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
25 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2 MVA Smallpox vaccine;Placebo
26 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2 Placebo (subcutaneous);Placebo (scarification)
27 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNEâ„¢) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
28 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
29 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
30 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
31 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
32 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
33 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
34 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
35 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
36 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
37 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
38 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
39 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
40 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
41 A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis Completed NCT01443260 Phase 1, Phase 2
42 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Completed NCT02038881 Phase 2
43 Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma Completed NCT01394939 Phase 1, Phase 2 Irinotecan
44 A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib Completed NCT01387555 Phase 2
45 A Study of Recombinant Vaccinia Virus Prior to Sorafenib to Treat Unresectable Primary Hepatocellular Carcinoma Completed NCT01171651 Phase 2 JX-594 followed by sorafenib
46 A Study of Recombinant Vaccinia Virus to Treat Unresectable Primary Hepatocellular Carcinoma Completed NCT00554372 Phase 2
47 A Study of Recombinant Vaccinia Virus to Treat Malignant Melanoma Completed NCT00429312 Phase 1, Phase 2
48 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNEâ„¢) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
49 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
50 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

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Genetic Tests for Milker's Nodule

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Anatomical Context for Milker's Nodule

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The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

19
Skin

MalaCards organs/tissues related to Milker's Nodule:

41
Skin, Liver, Prostate, B Cells, T Cells, Testis, Eye
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Publications for Milker's Nodule

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Articles related to Milker's Nodule:

(show all 11)
# Title Authors Year
1
Dermoscopic features and types of orf and milker's nodule. ( 28951712 )
2017
2
Milker's nodule: an occupational infection and threat to the immunocompromised. ( 29125649 )
2017
3
Milker's nodule--Case report. ( 26131876 )
2015
4
Milker's nodule--case report. ( 17631788 )
2007
5
Milker's nodule in a healthy young woman. ( 14576676 )
2003
6
Milker's nodule--a report of 15 cases in the county of North Jutland. ( 8721513 )
1996
7
Bullous eruption complicating a milker's nodule. ( 2834299 )
1988
8
Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. ( 4317817 )
1970
9
Milker's nodule. A clinical and electron microscopic report. ( 4313268 )
1970
10
Milker's nodule virus infections in Dorset and their similarity to orf. ( 4286392 )
1965
11
Cowpox in man and its relationship with milker's nodules. ( 14368868 )
1955
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Variations for Milker's Nodule

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Expression for Milker's Nodule

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Search GEO for disease gene expression data for Milker's Nodule.
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Pathways for Milker's Nodule

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GO Terms for Milker's Nodule

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Sources for Milker's Nodule

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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