Milker's Nodule disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule ¹² ¹⁵ ¹⁷

Poxviridae Infections ⁴³ ⁷¹

Milker's Nodes ⁷¹

Milker Nodule ¹²

Milkers' Node ¹²

Paravaccinia ¹²

Pseudocowpox ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8729

ICD9CM ³⁴ 051.9

MeSH ⁴³ D011213

SNOMED-CT ⁶⁷ 27240009

ICD10 ³² B08.04

EFO ¹⁷ EFO_0007370

UMLS ⁷¹ C0026143 C0032870

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Summaries for Milker's Nodule

Disease Ontology : ¹² A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and stomatitis, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is PDGFC (Platelet Derived Growth Factor C), and among its related pathways/superpathways are PAK Pathway and MAPK signaling pathway. The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is homeostasis/metabolism.

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Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)

#	Related Disease	Score	Top Affiliating Genes
1	erythema multiforme	10.4
2	stomatitis	10.4
3	keratosis	10.3
4	skin disease	10.3
5	diarrhea	10.2
6	vulvovaginitis	10.2
7	graft-versus-host disease	10.1
8	ecthyma	10.1
9	tularemia	10.1
10	vaccinia	10.1
11	anthrax disease	10.1
12	herpes simplex	10.1
13	cowpox	10.1
14	lymphangitis	10.1
15	pseudohypoparathyroidism, type ia	10.1
16	myeloma, multiple	10.1
17	exanthem	10.1
18	acrodermatitis	10.1
19	monocytic leukemia	10.1
20	gianotti crosti syndrome	10.1
21	contagious pustular dermatitis	9.7	VIL1 PDGFC FAIM
22	twin-to-twin transfusion syndrome	9.5	VEGFC PGF
23	kuhnt-junius degeneration	9.5	VEGFC PGF
24	diabetic macular edema	9.4	VEGFC PGF
25	macular degeneration, age-related, 1	9.0	VEGFC PGF PDGFC

Graphical network of the top 20 diseases related to Milker's Nodule:

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Symptoms & Phenotypes for Milker's Nodule

Symptoms:

¹²

• fever
• lymphadenopathy

• lymphangitis

MGI Mouse Phenotypes related to Milker's Nodule:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.17	FAIM FHL1 KLHL2 PDGFC PGF VEGFC

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Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cantharidin

Approved, Investigational

Phase 3

56-25-7

2

Pharmaceutical Solutions

Phase 3

3

Bevacizumab

Approved, Investigational

Phase 1, Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

4

Vaccines

Phase 2

5

Angiogenesis Inhibitors

Phase 1, Phase 2

6

Antineoplastic Agents, Immunological

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum	Completed	NCT03377803	Phase 3	VP-102;Placebo
2	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum	Completed	NCT03377790	Phase 3	VP-102;Placebo
3	Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults.	Completed	NCT00258947	Phase 2
4	Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15)	Recruiting	NCT02759588	Phase 1, Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

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Genetic Tests for Milker's Nodule

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Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

¹⁹

Skin

MalaCards organs/tissues related to Milker's Nodule:

⁴⁰

Skin

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Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 29)

#	Title	Authors	PMID	Year
1	Human Orf: An Under-recognized Entity. ⁶¹	Santiago L...Figueired A	31969245	2019
2	Milker's Nodule. ⁶¹	Jayasree P...Abraham R	31642868	2019
3	Milker's nodule: an occupational infection and threat to the immunocompromised. ⁶¹	Handler NS...Schwartz RA	29125649	2018
4	Milker's nodules: classic histological findings. ⁶¹	Esposito ACC...Abbade LPF	29364443	2017
5	Dermoscopic features and types of orf and milker's nodule. ⁶¹	Ayhan E...Aktas H	28951712	2017
6	Acral manifestations of viral infections. ⁶¹	Adisen E...Onder M	27938811	2017
7	Milker's nodule--Case report. ⁶¹	Adriano AR...Bonini F	26131876	2015
8	[Milker's nodule complicated with erythema multiforme]. ⁶¹	Batalla A...Curto JR	23562308	2013
9	The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. ⁶¹	Vogel S...Wollenberg A	22041995	2012
10	Molecular diagnostics of parapox virus infections. ⁶¹	Tondury B...Borelli S	20497283	2010
11	Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. ⁶¹	Abrahao JS...Kroon EG	20207192	2010
12	[Histopathology of the more common viral skin infections]. ⁶¹	Requena L...Requena C	20398595	2010
13	Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. ⁶¹	Werner B...Cerroni L	18616762	2008
14	Milker's nodule--case report. ⁶¹	Ceovic R...Persic Z	17631788	2007
15	Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. ⁶¹	Dar NR...Raza N	16977822	2006
16	Milker's nodule in a healthy young woman. ⁶¹	Werchniak AE...Baughman RD	14576676	2003
17	[Milker's nodules]. ⁶¹	Hansen SK...Veien NK	9045438	1997
18	Milker's nodule--a report of 15 cases in the county of North Jutland. ⁶¹	Hansen SK...Veien NK	8721513	1996
19	Bullous eruption complicating a milker's nodule. ⁶¹	Labeille B...Denoeux JP	2834299	1988
20	'Milker's nodule' contracted from pox in water buffaloes. ⁶¹	Mitra K...Chatterjee A	3025126	1986
21	[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. ⁶¹	Hartmann AA...Elsner P	3910614	1985
22	Some enzymatic activities associated with purified parapoxvirions. ⁶¹	Caplen HS...Holowczak JA	6188861	1983
23	The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. ⁶¹	Schuler G...Wolff K	6279706	1982
24	[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. ⁶¹	Liebermann H...Jung H	203242	1977
25	Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. ⁶¹	Davis CM...Trochet JA	4317817	1970
26	Milker's nodule. A clinical and electron microscopic report. ⁶¹	Davis CM...Musil G	4313268	1970
27	Milker's nodule virus infections in Dorset and their similarity to orf. ⁶¹	Nagington J...Smith JS	4286392	1965
28	Milker's nodules: isolation of a poxvirus from a human case. ⁶¹	FRIEDMAN-KIEN AE...BANFIELD WG	13959825	1963
29	[Milker's nodule with staphylococcal superinfection]. ⁶¹	ORMEA F...ARGANO W	13731234	1961

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Genes for Milker's Nodule

Genes related to Milker's Nodule (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PDGFC	Platelet Derived Growth Factor C	Protein Coding	6.03	DISEASES inferred ¹⁵
2	FHL1	Four And A Half LIM Domains 1	Protein Coding	5.23	DISEASES inferred ¹⁵
3	VIL1	Villin 1	Protein Coding	5.17	DISEASES inferred ¹⁵
4	KLHL2	Kelch Like Family Member 2	Protein Coding	4.94	DISEASES inferred ¹⁵
5	FAIM	Fas Apoptotic Inhibitory Molecule	Protein Coding	4.9	DISEASES inferred ¹⁵
6	MT3	Metallothionein 3	Protein Coding	4.74	DISEASES inferred ¹⁵
7	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	4.7	DISEASES inferred ¹⁵
8	PGF	Placental Growth Factor	Protein Coding	4.67	DISEASES inferred ¹⁵
9	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	4.64	DISEASES inferred ¹⁵

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Variations for Milker's Nodule

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Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

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Pathways for Milker's Nodule

Pathways related to Milker's Nodule according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.74	VEGFC PGF PDGFC ANAPC11
2	MAPK signaling pathway ³⁶ ¹	12.25	VEGFC PGF PDGFC
3	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.14	VEGFC PGF PDGFC
4	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.05	VEGFC PGF PDGFC
5	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.54	VEGFC PGF PDGFC
6	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.4	VEGFC PGF
7	G-protein signaling_RhoA regulation pathway ²²	10.82	VEGFC PGF PDGFC
8	VEGF binds to VEGFR leading to receptor dimerization ⁶⁵ Show member pathways VEGF ligand-receptor interactions ⁶⁵	9.83	VEGFC PGF

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GO Terms for Milker's Nodule

Biological processes related to Milker's Nodule according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell migration	GO:0030335	9.65	VIL1 VEGFC PDGFC
2	positive regulation of protein phosphorylation	GO:0001934	9.61	VEGFC PGF MT3
3	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043154	9.54	VIL1 MT3
4	response to hypoxia	GO:0001666	9.54	VEGFC PGF MT3
5	positive regulation of endothelial cell proliferation	GO:0001938	9.52	VEGFC PGF
6	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.51	VEGFC PGF
7	animal organ morphogenesis	GO:0009887	9.5	VEGFC PDGFC FHL1
8	positive chemotaxis	GO:0050918	9.49	VEGFC PGF
9	sprouting angiogenesis	GO:0002040	9.46	VEGFC PGF
10	positive regulation of protein autophosphorylation	GO:0031954	9.4	VEGFC PDGFC
11	vascular endothelial growth factor signaling pathway	GO:0038084	9.26	VEGFC PGF
12	induction of positive chemotaxis	GO:0050930	9.16	VEGFC PGF
13	positive regulation of mast cell chemotaxis	GO:0060754	8.96	VEGFC PGF
14	positive regulation of cell division	GO:0051781	8.8	VEGFC PGF PDGFC

Molecular functions related to Milker's Nodule according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemoattractant activity	GO:0042056	9.26	VEGFC PGF
2	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO:0043027	9.16	VIL1 MT3
3	growth factor activity	GO:0008083	9.13	VEGFC PGF PDGFC
4	vascular endothelial growth factor receptor binding	GO:0005172	8.62	VEGFC PGF

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Sources for Milker's Nodule

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia