MCID: MLK001
MIFTS: 30

Milker's Nodule

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule 12 15 17
Poxviridae Infections 44 71
Milker's Nodes 71
Milker Nodule 12
Milkers' Node 12
Paravaccinia 12
Pseudocowpox 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8729
ICD9CM 34 051.9
MeSH 44 D011213
SNOMED-CT 67 266193008
ICD10 32 B08.04
UMLS 71 C0026143 C0032870

Summaries for Milker's Nodule

Disease Ontology : 12 A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and skin disease, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is PDGFC (Platelet Derived Growth Factor C), and among its related pathways/superpathways are PAK Pathway and Nanog in Mammalian ESC Pluripotency. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 10.2
2 skin disease 10.2
3 cowpox 10.2
4 keratosis 10.1
5 graft-versus-host disease 10.0
6 tularemia 10.0
7 anthrax disease 10.0
8 stomatitis 10.0
9 vaccinia 9.9
10 ecthyma 9.9
11 diarrhea 9.9
12 vulvovaginitis 9.9
13 contagious pustular dermatitis 9.7 VIL1 PDGFC FAIM
14 twin-to-twin transfusion syndrome 9.6 VEGFC PGF
15 kuhnt-junius degeneration 9.6 VEGFC PGF
16 macular degeneration, age-related, 1 9.3 VEGFC PGF PDGFC

Graphical network of the top 20 diseases related to Milker's Nodule:



Diseases related to Milker's Nodule

Symptoms & Phenotypes for Milker's Nodule

Symptoms:

12
  • fever
  • lymphadenopathy
  • lymphangitis

Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults. Completed NCT00258947 Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

Genetic Tests for Milker's Nodule

Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

19
Skin

MalaCards organs/tissues related to Milker's Nodule:

40
Skin

Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 30)
# Title Authors PMID Year
1
Milker's nodule: An under-reported and under-diagnosed occupational infection. 61
32695349 2020
2
Milker's Nodule. 61
31642868 2020
3
Human Orf: An Under-recognized Entity. 61
31969245 2019
4
Milker's nodule: an occupational infection and threat to the immunocompromised. 61
29125649 2018
5
Milker's nodules: classic histological findings. 61
29364443 2017
6
Dermoscopic features and types of orf and milker's nodule. 61
28951712 2017
7
Acral manifestations of viral infections. 61
27938811 2017
8
Milker's nodule--Case report. 61
26131876 2015
9
[Milker's nodule complicated with erythema multiforme]. 61
23562308 2013
10
The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. 61
22041995 2012
11
Molecular diagnostics of parapox virus infections. 61
20497283 2010
12
Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. 61
20207192 2010
13
[Histopathology of the more common viral skin infections]. 61
20398595 2010
14
Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. 61
18616762 2008
15
Milker's nodule--case report. 61
17631788 2007
16
Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. 61
16977822 2006
17
Milker's nodule in a healthy young woman. 61
14576676 2003
18
[Milker's nodules]. 61
9045438 1997
19
Milker's nodule--a report of 15 cases in the county of North Jutland. 61
8721513 1996
20
Bullous eruption complicating a milker's nodule. 61
2834299 1988
21
'Milker's nodule' contracted from pox in water buffaloes. 61
3025126 1986
22
[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. 61
3910614 1985
23
Some enzymatic activities associated with purified parapoxvirions. 61
6188861 1983
24
The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. 61
6279706 1982
25
[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. 61
203242 1977
26
Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. 61
4317817 1970
27
Milker's nodule. A clinical and electron microscopic report. 61
4313268 1970
28
Milker's nodule virus infections in Dorset and their similarity to orf. 61
4286392 1965
29
Milker's nodules: isolation of a poxvirus from a human case. 61
13959825 1963
30
[Milker's nodule with staphylococcal superinfection]. 61
13731234 1961

Variations for Milker's Nodule

Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

Pathways for Milker's Nodule

Pathways related to Milker's Nodule according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 VEGFC PGF PDGFC ANAPC11
2
Show member pathways
12.72 VEGFC PGF PDGFC BDKRB1
3 12.43 VEGFC PGF BDKRB1
4 12.32 VEGFC PGF PDGFC
5
Show member pathways
12.28 VEGFC PGF PDGFC
6
Show member pathways
12.2 VEGFC PGF PDGFC
7 12.07 VIL1 PDGFC BDKRB1
8
Show member pathways
11.97 VEGFC PGF PDGFC
9
Show member pathways
11.64 VEGFC PGF PDGFC
10 11.51 VEGFC PDGFC BDKRB1
11
Show member pathways
11.47 VEGFC PGF
12 11.02 VEGFC PGF PDGFC
13 10.62 VEGFC PGF PDGFC
14
Show member pathways
9.83 VEGFC PGF

GO Terms for Milker's Nodule

Biological processes related to Milker's Nodule according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 VEGFC PGF PDGFC
2 positive regulation of cell migration GO:0030335 9.65 VIL1 VEGFC PDGFC
3 positive regulation of protein phosphorylation GO:0001934 9.58 VEGFC PGF MT3
4 positive regulation of endothelial cell proliferation GO:0001938 9.54 VEGFC PGF
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.52 VIL1 MT3
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.51 VEGFC PGF
7 response to hypoxia GO:0001666 9.5 VEGFC PGF MT3
8 positive chemotaxis GO:0050918 9.49 VEGFC PGF
9 sprouting angiogenesis GO:0002040 9.46 VEGFC PGF
10 negative regulation of blood pressure GO:0045776 9.43 VEGFC BDKRB1
11 positive regulation of protein autophosphorylation GO:0031954 9.37 VEGFC PDGFC
12 vascular endothelial growth factor signaling pathway GO:0038084 9.26 VEGFC PGF
13 induction of positive chemotaxis GO:0050930 9.16 VEGFC PGF
14 positive regulation of mast cell chemotaxis GO:0060754 8.96 VEGFC PGF
15 positive regulation of cell division GO:0051781 8.8 VEGFC PGF PDGFC

Molecular functions related to Milker's Nodule according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.26 VEGFC PGF
2 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 9.16 VIL1 MT3
3 growth factor activity GO:0008083 9.13 VEGFC PGF PDGFC
4 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFC PGF

Sources for Milker's Nodule

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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