MCID: MLK001
MIFTS: 24

Milker's Nodule

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule 12 15 17
Poxviridae Infections 44 72
Milker's Nodes 72
Milker Nodule 12
Milkers' Node 12
Paravaccinia 12
Pseudocowpox 12

Classifications:



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Disease Ontology 12 DOID:8729
ICD9CM 35 051.1 051.9
MeSH 44 D011213
SNOMED-CT 68 27240009
ICD10 33 B08.04
UMLS 72 C0026143 C0032870

Summaries for Milker's Nodule

Disease Ontology : 12 A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and stomatitis, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is TNFRSF8 (TNF Receptor Superfamily Member 8). The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and skin.

Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 10.4
2 stomatitis 10.4
3 skin disease 10.3
4 diarrhea 10.2
5 keratosis 10.2
6 vulvovaginitis 10.2
7 pulmonary alveolar microlithiasis 10.1
8 graft-versus-host disease 10.1
9 ecthyma 10.1
10 tularemia 10.1
11 vaccinia 10.1
12 anthrax disease 10.1
13 herpes simplex 10.1
14 cowpox 10.1
15 lymphangitis 10.1
16 pseudohypoparathyroidism, type ia 10.1
17 myeloma, multiple 10.1
18 exanthem 10.1
19 acrodermatitis 10.1
20 monocytic leukemia 10.1
21 gianotti crosti syndrome 10.1
22 pseudohypoparathyroidism with albright hereditary osteodystrophy 10.1
23 hematopoietic stem cell transplantation 10.1

Graphical network of the top 20 diseases related to Milker's Nodule:



Diseases related to Milker's Nodule

Symptoms & Phenotypes for Milker's Nodule

Symptoms:

12
  • fever
  • lymphadenopathy
  • lymphangitis

Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3 56-25-7
2 Pharmaceutical Solutions Phase 3
3
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
4 Vaccines Phase 2
5 Immunologic Factors Phase 2
6 Angiogenesis Inhibitors Phase 1, Phase 2
7 Angiogenesis Modulating Agents Phase 1, Phase 2
8 Antineoplastic Agents, Immunological Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377803 Phase 3 VP-102;Placebo
2 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377790 Phase 3 VP-102;Placebo
3 Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults. Completed NCT00258947 Phase 2
4 Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15) Recruiting NCT02759588 Phase 1, Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

Genetic Tests for Milker's Nodule

Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

19
Skin

MalaCards organs/tissues related to Milker's Nodule:

41
Skin

Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 27)
# Title Authors PMID Year
1
Milker's nodule: an occupational infection and threat to the immunocompromised. 38
29125649 2018
2
Milker's nodules: classic histological findings. 38
29364443 2017
3
Dermoscopic features and types of orf and milker's nodule. 38
28951712 2017
4
Acral manifestations of viral infections. 38
27938811 2017
5
Milker's nodule--Case report. 38
26131876 2015
6
[Milker's nodule complicated with erythema multiforme]. 38
23562308 2013
7
The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. 38
22041995 2012
8
Molecular diagnostics of parapox virus infections. 38
20497283 2010
9
Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. 38
20207192 2010
10
[Histopathology of the more common viral skin infections]. 38
20398595 2010
11
Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. 38
18616762 2008
12
Milker's nodule--case report. 38
17631788 2007
13
Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. 38
16977822 2006
14
Milker's nodule in a healthy young woman. 38
14576676 2003
15
[Milker's nodules]. 38
9045438 1997
16
Milker's nodule--a report of 15 cases in the county of North Jutland. 38
8721513 1996
17
Bullous eruption complicating a milker's nodule. 38
2834299 1988
18
'Milker's nodule' contracted from pox in water buffaloes. 38
3025126 1986
19
[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. 38
3910614 1985
20
Some enzymatic activities associated with purified parapoxvirions. 38
6188861 1983
21
The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. 38
6279706 1982
22
[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. 38
203242 1977
23
Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. 38
4317817 1970
24
Milker's nodule. A clinical and electron microscopic report. 38
4313268 1970
25
Milker's nodule virus infections in Dorset and their similarity to orf. 38
4286392 1965
26
Milker's nodules: isolation of a poxvirus from a human case. 38
13959825 1963
27
[Milker's nodule with staphylococcal superinfection]. 38
13731234 1961

Variations for Milker's Nodule

Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

Pathways for Milker's Nodule

GO Terms for Milker's Nodule

Sources for Milker's Nodule

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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