Milker's Nodule disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule ¹² ¹⁵ ¹⁷

Poxviridae Infections ⁴⁴ ⁷²

Milker's Nodes ⁷²

Milker Nodule ¹²

Milkers' Node ¹²

Paravaccinia ¹²

Pseudocowpox ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8729

ICD9CM ³⁵ 051.1 051.9

MeSH ⁴⁴ D011213

SNOMED-CT ⁶⁸ 27240009

ICD10 ³³ B08.04

EFO ¹⁷ EFO_0007370

UMLS ⁷² C0026143 C0032870

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Summaries for Milker's Nodule

Disease Ontology : ¹² A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and stomatitis, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is TNFRSF8 (TNF Receptor Superfamily Member 8). The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and skin.

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Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)

#	Related Disease	Score
1	erythema multiforme	10.4
2	stomatitis	10.4
3	skin disease	10.3
4	diarrhea	10.2
5	keratosis	10.2
6	vulvovaginitis	10.2
7	pulmonary alveolar microlithiasis	10.1
8	graft-versus-host disease	10.1
9	ecthyma	10.1
10	tularemia	10.1
11	vaccinia	10.1
12	anthrax disease	10.1
13	herpes simplex	10.1
14	cowpox	10.1
15	lymphangitis	10.1
16	pseudohypoparathyroidism, type ia	10.1
17	myeloma, multiple	10.1
18	exanthem	10.1
19	acrodermatitis	10.1
20	monocytic leukemia	10.1
21	gianotti crosti syndrome	10.1
22	pseudohypoparathyroidism with albright hereditary osteodystrophy	10.1
23	hematopoietic stem cell transplantation	10.1

Graphical network of the top 20 diseases related to Milker's Nodule:

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Symptoms & Phenotypes for Milker's Nodule

Symptoms:

¹²

• fever
• lymphadenopathy

• lymphangitis

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Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cantharidin

Approved, Investigational

Phase 3

56-25-7

2

Pharmaceutical Solutions

Phase 3

3

Bevacizumab

Approved, Investigational

Phase 1, Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

4

Vaccines

Phase 2

5

Immunologic Factors

Phase 2

6

Angiogenesis Inhibitors

Phase 1, Phase 2

7

Angiogenesis Modulating Agents

Phase 1, Phase 2

8

Antineoplastic Agents, Immunological

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum	Completed	NCT03377803	Phase 3	VP-102;Placebo
2	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum	Completed	NCT03377790	Phase 3	VP-102;Placebo
3	Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults.	Completed	NCT00258947	Phase 2
4	Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15)	Recruiting	NCT02759588	Phase 1, Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

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Genetic Tests for Milker's Nodule

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Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

¹⁹

Skin

MalaCards organs/tissues related to Milker's Nodule:

⁴¹

Skin

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Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 27)

#	Title	Authors	PMID	Year
1	Milker's nodule: an occupational infection and threat to the immunocompromised. ³⁸	Handler NS...Schwartz RA	29125649	2018
2	Milker's nodules: classic histological findings. ³⁸	Esposito ACC...Abbade LPF	29364443	2017
3	Dermoscopic features and types of orf and milker's nodule. ³⁸	Ayhan E...Aktas H	28951712	2017
4	Acral manifestations of viral infections. ³⁸	Adisen E...Onder M	27938811	2017
5	Milker's nodule--Case report. ³⁸	Adriano AR...Bonini F	26131876	2015
6	[Milker's nodule complicated with erythema multiforme]. ³⁸	Batalla A...Curto JR	23562308	2013
7	The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. ³⁸	Vogel S...Wollenberg A	22041995	2012
8	Molecular diagnostics of parapox virus infections. ³⁸	Tondury B...Borelli S	20497283	2010
9	Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. ³⁸	Abrahao JS...Kroon EG	20207192	2010
10	[Histopathology of the more common viral skin infections]. ³⁸	Requena L...Requena C	20398595	2010
11	Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. ³⁸	Werner B...Cerroni L	18616762	2008
12	Milker's nodule--case report. ³⁸	Ceovic R...Persic Z	17631788	2007
13	Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. ³⁸	Dar NR...Raza N	16977822	2006
14	Milker's nodule in a healthy young woman. ³⁸	Werchniak AE...Baughman RD	14576676	2003
15	[Milker's nodules]. ³⁸	Hansen SK...Veien NK	9045438	1997
16	Milker's nodule--a report of 15 cases in the county of North Jutland. ³⁸	Hansen SK...Veien NK	8721513	1996
17	Bullous eruption complicating a milker's nodule. ³⁸	Labeille B...Denoeux JP	2834299	1988
18	'Milker's nodule' contracted from pox in water buffaloes. ³⁸	Mitra K...Chatterjee A	3025126	1986
19	[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. ³⁸	Hartmann AA...Elsner P	3910614	1985
20	Some enzymatic activities associated with purified parapoxvirions. ³⁸	Caplen HS...Holowczak JA	6188861	1983
21	The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. ³⁸	Schuler G...Wolff K	6279706	1982
22	[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. ³⁸	Liebermann H...Jung H	203242	1977
23	Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. ³⁸	Davis CM...Trochet JA	4317817	1970
24	Milker's nodule. A clinical and electron microscopic report. ³⁸	Davis CM...Musil G	4313268	1970
25	Milker's nodule virus infections in Dorset and their similarity to orf. ³⁸	Nagington J...Smith JS	4286392	1965
26	Milker's nodules: isolation of a poxvirus from a human case. ³⁸	FRIEDMAN-KIEN AE...BANFIELD WG	13959825	1963
27	[Milker's nodule with staphylococcal superinfection]. ³⁸	ORMEA F...ARGANO W	13731234	1961

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Genes for Milker's Nodule

Genes related to Milker's Nodule (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	5.11	DISEASES inferred ¹⁵

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Variations for Milker's Nodule

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Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

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Pathways for Milker's Nodule

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GO Terms for Milker's Nodule

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Sources for Milker's Nodule

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