MCID: MLK001
MIFTS: 33

Milker's Nodule

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule 12 15 17
Poxviridae Infections 43 71
Milker's Nodes 71
Milker Nodule 12
Milkers' Node 12
Paravaccinia 12
Pseudocowpox 12

Classifications:



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Disease Ontology 12 DOID:8729
ICD9CM 34 051.1 051.9
MeSH 43 D011213
SNOMED-CT 67 27240009
ICD10 32 B08.04
UMLS 71 C0026143 C0032870

Summaries for Milker's Nodule

Disease Ontology : 12 A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and stomatitis, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is PDGFC (Platelet Derived Growth Factor C), and among its related pathways/superpathways are PAK Pathway and Ras signaling pathway. The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and monocytes, and related phenotype is homeostasis/metabolism.

Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 10.4
2 stomatitis 10.4
3 skin disease 10.3
4 diarrhea 10.2
5 keratosis 10.2
6 vulvovaginitis 10.2
7 graft-versus-host disease 10.1
8 ecthyma 10.1
9 tularemia 10.1
10 vaccinia 10.1
11 anthrax disease 10.1
12 herpes simplex 10.1
13 cowpox 10.1
14 lymphangitis 10.1
15 pseudohypoparathyroidism, type ia 10.1
16 myeloma, multiple 10.1
17 exanthem 10.1
18 acrodermatitis 10.1
19 monocytic leukemia 10.1
20 gianotti crosti syndrome 10.1
21 contagious pustular dermatitis 9.8 VIL1 PDGFC FAIM
22 twin-to-twin transfusion syndrome 9.4 VEGFC PGF
23 neovascular glaucoma 9.4 VEGFC PGF
24 diabetic macular edema 9.3 VEGFC PGF
25 kuhnt-junius degeneration 9.3 VEGFC PGF PDGFC
26 exudative vitreoretinopathy 1 9.2 VEGFC PGF PDGFC
27 macular degeneration, age-related, 1 8.9 VEGFC PGF PDGFC

Graphical network of the top 20 diseases related to Milker's Nodule:



Diseases related to Milker's Nodule

Symptoms & Phenotypes for Milker's Nodule

Symptoms:

12
  • fever
  • lymphadenopathy
  • lymphangitis

MGI Mouse Phenotypes related to Milker's Nodule:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 FAIM KLHL2 PDGFC PGF SLC22A8 VEGFC

Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3 56-25-7
2 Pharmaceutical Solutions Phase 3
3
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
4 Vaccines Phase 2
5 Immunologic Factors Phase 2
6 Antineoplastic Agents, Immunological Phase 1, Phase 2
7 Angiogenesis Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377803 Phase 3 VP-102;Placebo
2 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377790 Phase 3 VP-102;Placebo
3 Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults. Completed NCT00258947 Phase 2
4 Phase 1b & 2 Study With GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer (VIRO-15) Recruiting NCT02759588 Phase 1, Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

Genetic Tests for Milker's Nodule

Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

19
Skin

MalaCards organs/tissues related to Milker's Nodule:

40
Skin, Monocytes

Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 29)
# Title Authors PMID Year
1
Human Orf: An Under-recognized Entity. 61
31969245 2019
2
Milker's Nodule. 61
31642868 2019
3
Milker's nodule: an occupational infection and threat to the immunocompromised. 61
29125649 2018
4
Milker's nodules: classic histological findings. 61
29364443 2017
5
Dermoscopic features and types of orf and milker's nodule. 61
28951712 2017
6
Acral manifestations of viral infections. 61
27938811 2017
7
Milker's nodule--Case report. 61
26131876 2015
8
[Milker's nodule complicated with erythema multiforme]. 61
23562308 2013
9
The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. 61
22041995 2012
10
Molecular diagnostics of parapox virus infections. 61
20497283 2010
11
Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. 61
20207192 2010
12
[Histopathology of the more common viral skin infections]. 61
20398595 2010
13
Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. 61
18616762 2008
14
Milker's nodule--case report. 61
17631788 2007
15
Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. 61
16977822 2006
16
Milker's nodule in a healthy young woman. 61
14576676 2003
17
[Milker's nodules]. 61
9045438 1997
18
Milker's nodule--a report of 15 cases in the county of North Jutland. 61
8721513 1996
19
Bullous eruption complicating a milker's nodule. 61
2834299 1988
20
'Milker's nodule' contracted from pox in water buffaloes. 61
3025126 1986
21
[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. 61
3910614 1985
22
Some enzymatic activities associated with purified parapoxvirions. 61
6188861 1983
23
The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. 61
6279706 1982
24
[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. 61
203242 1977
25
Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. 61
4317817 1970
26
Milker's nodule. A clinical and electron microscopic report. 61
4313268 1970
27
Milker's nodule virus infections in Dorset and their similarity to orf. 61
4286392 1965
28
Milker's nodules: isolation of a poxvirus from a human case. 61
13959825 1963
29
[Milker's nodule with staphylococcal superinfection]. 61
13731234 1961

Variations for Milker's Nodule

Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

Pathways for Milker's Nodule

Pathways related to Milker's Nodule according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 VEGFC PGF PDGFC ANAPC11
2
Show member pathways
12.14 VEGFC PGF PDGFC
3
Show member pathways
12.05 VEGFC PGF PDGFC
4
Show member pathways
11.54 VEGFC PGF PDGFC
5
Show member pathways
11.37 VEGFC PGF
6 10.82 VEGFC PGF PDGFC
7
Show member pathways
9.83 VEGFC PGF

GO Terms for Milker's Nodule

Biological processes related to Milker's Nodule according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of endothelial cell proliferation GO:0001938 9.46 VEGFC PGF
2 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.43 VEGFC PGF
3 positive chemotaxis GO:0050918 9.4 VEGFC PGF
4 sprouting angiogenesis GO:0002040 9.37 VEGFC PGF
5 positive regulation of protein autophosphorylation GO:0031954 9.32 VEGFC PDGFC
6 vascular endothelial growth factor signaling pathway GO:0038084 9.26 VEGFC PGF
7 induction of positive chemotaxis GO:0050930 9.16 VEGFC PGF
8 positive regulation of mast cell chemotaxis GO:0060754 8.96 VEGFC PGF
9 positive regulation of cell division GO:0051781 8.8 VEGFC PGF PDGFC

Molecular functions related to Milker's Nodule according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFC PGF
2 growth factor activity GO:0008083 9.13 VEGFC PGF PDGFC
3 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFC PGF

Sources for Milker's Nodule

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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