Milker's Nodule disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MLK001 MIFTS: 30	Milker's Nodule Categories: Infectious diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Milker's Nodule

MalaCards integrated aliases for Milker's Nodule:

Name: Milker's Nodule ¹² ¹⁵ ¹⁷

Poxviridae Infections ⁴⁴ ⁷¹

Milker's Nodes ⁷¹

Milker Nodule ¹²

Milkers' Node ¹²

Paravaccinia ¹²

Pseudocowpox ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8729

ICD9CM ³⁴ 051.9

MeSH ⁴⁴ D011213

SNOMED-CT ⁶⁷ 266193008

ICD10 ³² B08.04

EFO ¹⁷ EFO_0007370

UMLS ⁷¹ C0026143 C0032870

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Summaries for Milker's Nodule

Disease Ontology : ¹² A viral infectious disease that results in infection of cattle and humans, located in skin, has material basis in Pseudocowpox virus, which is transmitted by contact with the infected cow teats, or transmitted by fomites. The infection results in formation of lesions on the fingers, hands, and forearms and has symptom fever, has symptom lymphangitis, and has symptom lymphadenopathy.

MalaCards based summary : Milker's Nodule, also known as poxviridae infections, is related to erythema multiforme and skin disease, and has symptoms including fever, lymphadenopathy and lymphangitis. An important gene associated with Milker's Nodule is PDGFC (Platelet Derived Growth Factor C), and among its related pathways/superpathways are PAK Pathway and Nanog in Mammalian ESC Pluripotency. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin.

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Related Diseases for Milker's Nodule

Diseases related to Milker's Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)

#	Related Disease	Score	Top Affiliating Genes
1	erythema multiforme	10.2
2	skin disease	10.2
3	cowpox	10.2
4	keratosis	10.1
5	graft-versus-host disease	10.0
6	tularemia	10.0
7	anthrax disease	10.0
8	stomatitis	10.0
9	vaccinia	9.9
10	ecthyma	9.9
11	diarrhea	9.9
12	vulvovaginitis	9.9
13	contagious pustular dermatitis	9.7	VIL1 PDGFC FAIM
14	twin-to-twin transfusion syndrome	9.6	VEGFC PGF
15	kuhnt-junius degeneration	9.6	VEGFC PGF
16	macular degeneration, age-related, 1	9.3	VEGFC PGF PDGFC

Graphical network of the top 20 diseases related to Milker's Nodule:

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Symptoms & Phenotypes for Milker's Nodule

Symptoms:

¹²

• fever
• lymphadenopathy

• lymphangitis

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Drugs & Therapeutics for Milker's Nodule

Drugs for Milker's Nodule (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Vaccines		Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Take Evaluation and Safety of Smallpox Vaccine (LISTER Strain) in Naïve Healthy Adults.	Completed	NCT00258947	Phase 2

Search NIH Clinical Center for Milker's Nodule

Cochrane evidence based reviews: poxviridae infections

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Genetic Tests for Milker's Nodule

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Anatomical Context for Milker's Nodule

The Foundational Model of Anatomy Ontology organs/tissues related to Milker's Nodule:

¹⁹

Skin

MalaCards organs/tissues related to Milker's Nodule:

⁴⁰

Skin

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Publications for Milker's Nodule

Articles related to Milker's Nodule:

(show all 30)

#	Title	Authors	PMID	Year
1	Milker's nodule: An under-reported and under-diagnosed occupational infection. ⁶¹	Poudel GP...Dhakal S	32695349	2020
2	Milker's Nodule. ⁶¹	Jayasree P...Abraham R	31642868	2020
3	Human Orf: An Under-recognized Entity. ⁶¹	Santiago L...Figueired A	31969245	2019
4	Milker's nodule: an occupational infection and threat to the immunocompromised. ⁶¹	Handler NS...Schwartz RA	29125649	2018
5	Milker's nodules: classic histological findings. ⁶¹	Esposito ACC...Abbade LPF	29364443	2017
6	Dermoscopic features and types of orf and milker's nodule. ⁶¹	Ayhan E...Aktas H	28951712	2017
7	Acral manifestations of viral infections. ⁶¹	Adisen E...Onder M	27938811	2017
8	Milker's nodule--Case report. ⁶¹	Adriano AR...Bonini F	26131876	2015
9	[Milker's nodule complicated with erythema multiforme]. ⁶¹	Batalla A...Curto JR	23562308	2013
10	The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. ⁶¹	Vogel S...Wollenberg A	22041995	2012
11	Molecular diagnostics of parapox virus infections. ⁶¹	Tondury B...Borelli S	20497283	2010
12	Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. ⁶¹	Abrahao JS...Kroon EG	20207192	2010
13	[Histopathology of the more common viral skin infections]. ⁶¹	Requena L...Requena C	20398595	2010
14	Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. ⁶¹	Werner B...Cerroni L	18616762	2008
15	Milker's nodule--case report. ⁶¹	Ceovic R...Persic Z	17631788	2007
16	Exuberant ulcerated lesions of secondary syphilis on the palms--an unusual presentation. ⁶¹	Dar NR...Raza N	16977822	2006
17	Milker's nodule in a healthy young woman. ⁶¹	Werchniak AE...Baughman RD	14576676	2003
18	[Milker's nodules]. ⁶¹	Hansen SK...Veien NK	9045438	1997
19	Milker's nodule--a report of 15 cases in the county of North Jutland. ⁶¹	Hansen SK...Veien NK	8721513	1996
20	Bullous eruption complicating a milker's nodule. ⁶¹	Labeille B...Denoeux JP	2834299	1988
21	'Milker's nodule' contracted from pox in water buffaloes. ⁶¹	Mitra K...Chatterjee A	3025126	1986
22	[Sero- and immunodiagnosis in parapoxvirus infections in the human. Milker's nodes, ecthyma contagiosum contact infection]. ⁶¹	Hartmann AA...Elsner P	3910614	1985
23	Some enzymatic activities associated with purified parapoxvirions. ⁶¹	Caplen HS...Holowczak JA	6188861	1983
24	The syndrome of milker's nodules in burn injury: evidence for indirect viral transmission. ⁶¹	Schuler G...Wolff K	6279706	1982
25	[Experimental infection of man using viral strains of bovine papular stomatitis, orf, pseudocowpox and milker's nodule]. ⁶¹	Liebermann H...Jung H	203242	1977
26	Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. ⁶¹	Davis CM...Trochet JA	4317817	1970
27	Milker's nodule. A clinical and electron microscopic report. ⁶¹	Davis CM...Musil G	4313268	1970
28	Milker's nodule virus infections in Dorset and their similarity to orf. ⁶¹	Nagington J...Smith JS	4286392	1965
29	Milker's nodules: isolation of a poxvirus from a human case. ⁶¹	FRIEDMAN-KIEN AE...BANFIELD WG	13959825	1963
30	[Milker's nodule with staphylococcal superinfection]. ⁶¹	ORMEA F...ARGANO W	13731234	1961

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Genes for Milker's Nodule

Genes related to Milker's Nodule (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PDGFC	Platelet Derived Growth Factor C	Protein Coding	6.04	DISEASES inferred ¹⁵
2	MT3	Metallothionein 3	Protein Coding	5.56	DISEASES inferred ¹⁵
3	VIL1	Villin 1	Protein Coding	5.28	DISEASES inferred ¹⁵
4	FAIM	Fas Apoptotic Inhibitory Molecule	Protein Coding	5.12	DISEASES inferred ¹⁵
5	BDKRB1	Bradykinin Receptor B1	Protein Coding	4.88	DISEASES inferred ¹⁵
6	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	4.77	DISEASES inferred ¹⁵
7	PGF	Placental Growth Factor	Protein Coding	4.67	DISEASES inferred ¹⁵
8	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	4.64	DISEASES inferred ¹⁵

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Variations for Milker's Nodule

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Expression for Milker's Nodule

Search GEO for disease gene expression data for Milker's Nodule.

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Pathways for Milker's Nodule

Pathways related to Milker's Nodule according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.8	VEGFC PGF PDGFC ANAPC11
2	Nanog in Mammalian ESC Pluripotency ⁶³ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶³ eNOS Signaling ⁶³ GSK3 Signaling ⁶³	12.72	VEGFC PGF PDGFC BDKRB1
3	Pathways in cancer ³⁶	12.43	VEGFC PGF BDKRB1
4	MAPK signaling pathway ³⁶ ¹	12.32	VEGFC PGF PDGFC
5	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.28	VEGFC PGF PDGFC
6	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.2	VEGFC PGF PDGFC
7	Regulation of actin cytoskeleton ³⁶ ¹	12.07	VIL1 PDGFC BDKRB1
8	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	11.97	VEGFC PGF PDGFC
9	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.64	VEGFC PGF PDGFC
10	Calcium signaling pathway ³⁶	11.51	VEGFC PDGFC BDKRB1
11	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.47	VEGFC PGF
12	G-protein signaling_RhoA regulation pathway ²³	11.02	VEGFC PGF PDGFC
13	G-protein signaling_Rap2B regulation pathway ²³	10.62	VEGFC PGF PDGFC
14	VEGF binds to VEGFR leading to receptor dimerization ⁶⁵ Show member pathways VEGF ligand-receptor interactions ⁶⁵	9.83	VEGFC PGF

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GO Terms for Milker's Nodule

Biological processes related to Milker's Nodule according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.72	VEGFC PGF PDGFC
2	positive regulation of cell migration	GO:0030335	9.65	VIL1 VEGFC PDGFC
3	positive regulation of protein phosphorylation	GO:0001934	9.58	VEGFC PGF MT3
4	positive regulation of endothelial cell proliferation	GO:0001938	9.54	VEGFC PGF
5	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043154	9.52	VIL1 MT3
6	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.51	VEGFC PGF
7	response to hypoxia	GO:0001666	9.5	VEGFC PGF MT3
8	positive chemotaxis	GO:0050918	9.49	VEGFC PGF
9	sprouting angiogenesis	GO:0002040	9.46	VEGFC PGF
10	negative regulation of blood pressure	GO:0045776	9.43	VEGFC BDKRB1
11	positive regulation of protein autophosphorylation	GO:0031954	9.37	VEGFC PDGFC
12	vascular endothelial growth factor signaling pathway	GO:0038084	9.26	VEGFC PGF
13	induction of positive chemotaxis	GO:0050930	9.16	VEGFC PGF
14	positive regulation of mast cell chemotaxis	GO:0060754	8.96	VEGFC PGF
15	positive regulation of cell division	GO:0051781	8.8	VEGFC PGF PDGFC

Molecular functions related to Milker's Nodule according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemoattractant activity	GO:0042056	9.26	VEGFC PGF
2	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO:0043027	9.16	VIL1 MT3
3	growth factor activity	GO:0008083	9.13	VEGFC PGF PDGFC
4	vascular endothelial growth factor receptor binding	GO:0005172	8.62	VEGFC PGF

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Sources for Milker's Nodule

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia