Miller Fisher Syndrome

Categories: Immune diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Miller Fisher Syndrome

MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 11 52 58 75 53 43 14 16 71
Cranial Variant of Gbs 19 58
Miller-Fisher Variant of Guillain-Barre Syndrome 11
Cranial Variant of Guillain-Barré Syndrome 19
Cranial Variant of Guillain-Barre Syndrome 58
Miller-Fisher Syndrome 19
Fisher's Syndrome 11
Fisher Syndrome 58



Multigenic/multifactorial 58


1-9/1000000 (Europe) 58

Age Of Onset:

All ages 58


Orphanet: 58  
Rare neurological diseases

External Ids:

Disease Ontology 11 DOID:12889
MeSH 43 D019846
NCIt 49 C116958
SNOMED-CT 68 1767005
ICD10 31 G61.0
MESH via Orphanet 44 D019846
ICD10 via Orphanet 32 G61.0
UMLS via Orphanet 72 C0393799
Orphanet 58 ORPHA98919
UMLS 71 C0393799

Summaries for Miller Fisher Syndrome

GARD: 19 Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barré syndrome. The main features are lack of muscle coordination (ataxia), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes. Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome.

MalaCards based summary: Miller Fisher Syndrome, also known as cranial variant of gbs, is related to guillain-barre syndrome and severe acute respiratory syndrome, and has symptoms including ophthalmoplegia and cerebellar ataxia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Spinal cord injury and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and dorsal root ganglion, and related phenotypes are nervous system and growth/size/body region

NINDS: 52 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Disease Ontology: 11 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

Orphanet: 58 Miller-Fisher syndrome (MFS) is a rare cranial nerve variant of Guillain-Barré syndrome (GBS; see this term).

Wikipedia: 75 Guillain-Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the... more...

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 598)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 32.7 TNF MOG ALB
2 severe acute respiratory syndrome 30.8 TNF TMPRSS2 IL6 ACE2
3 polyneuropathy 30.8 NFASC MAG CNTN1 ALB
4 viral infectious disease 30.8 TNF IL6 CCR6 ACE2
5 covid-19 30.8 TNF TMPRSS2 IL6 CCR6 ACE2
6 bell's palsy 30.7 TNF IL6 ALB ACE2
7 abducens palsy 30.7 MUSK MOG AQP4
8 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 NFASC MUSK MAG CNTN1
9 autoimmune peripheral neuropathy 30.4 NFASC MAG CNTN1
10 pharyngitis 30.3 TNF IL6 CCR6
11 neuritis 30.3 TNF MOG MAG IL6 AQP4
12 adult-onset still's disease 30.3 TNF IL6 CCR6
13 optic neuritis 30.2 TNF MOG MAG IL6 AQP4
14 human cytomegalovirus infection 30.2 TNF IL6 CCR6
15 common cold 30.2 TNF TMPRSS2 IL6 CCR6 ACE2
16 autoimmune neuropathy 30.1 NFASC MAG LGI1 CNTNAP2 CNTN1
17 dengue disease 30.1 TNF IL6 CCR6 ALB
18 juvenile rheumatoid arthritis 30.1 TNF IL6 CCR6
19 gastroenteritis 30.0 TNF IL6 ALB
20 internuclear ophthalmoplegia 30.0 PNMA2 MUSK MOG AQP4
21 facial paralysis 30.0 TNF MOG IL6 AQP4 ALB ACE2
22 lambert-eaton myasthenic syndrome 30.0 TNF MUSK AMPH
23 wernicke encephalopathy 29.9 PNMA2 AQP4 ALB
24 neuromuscular disease 29.9 MUSK MAG AMPH ALB
25 neuromyelitis optica 29.9 MOG IL6 AQP4
26 autonomic nervous system disease 29.8 TNF IL6 ALB
27 appendicitis 29.8 TNF IL6 ALB
28 intestinal obstruction 29.8 TNF IL6 ALB
29 meningitis 29.8 TNF IL6 AQP4 ALB
30 intracranial hypertension 29.8 TNF IL6 AQP4 ALB
31 pneumonia 29.7 TNF IL6 ALB ACE2
32 demyelinating disease 29.7 TNF MOG MAG IL6 CCR6 AQP4
33 papilledema 29.7 MOG IL6 AQP4 ALB
34 exanthem 29.7 TNF IL6 CCR6 ALB
35 urinary tract infection 29.7 TNF IL6 CCR6 ALB
36 typhoid fever 29.7 TNF IL6 CCR6 ALB
37 respiratory failure 29.7 TNF TMPRSS2 MUSK IL6 CCR6 ALB
38 monoclonal gammopathy of uncertain significance 29.7 MAG IL6 CCR6 ALB
39 crohn's disease 29.7 TNF IL6 CCR6 ALB
40 aseptic meningitis 29.7 TNF MOG IL6 ALB
41 movement disease 29.6 LGI1 GAD2 CNTNAP2 AMPH
42 cerebrovascular disease 29.6 TNF IL6 CCR6 ALB
43 rheumatic fever 29.6 TNF IL6 ALB
44 encephalitis 29.6 TNF PNMA2 MOG LGI1 IL6 CNTNAP2
45 stroke, ischemic 29.6 TNF IL6 AQP4 ALB ACE2
46 cranial nerve palsy 29.5 TNF MOG AQP4 ALB
47 brachial plexus neuritis 29.5 NFASC MUSK MOG LGI1 AQP4
48 uremia 29.5 TNF IL6 ALB
49 inappropriate adh syndrome 29.5 LGI1 IL6 AQP4 ALB
50 coronavirus infectious disease 29.3 TNF TMPRSS2 IL6 CCR6 ALB ACE2

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:

Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:

ophthalmoplegia; cerebellar ataxia

MGI Mouse Phenotypes related to Miller Fisher Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.17 AMPH AQP4 CCR6 CNTN1 CNTNAP2 GAD2
2 growth/size/body region MP:0005378 9.97 ACE2 AQP4 CNTN1 CNTNAP2 GAD2 IL6
3 muscle MP:0005369 9.96 ACE2 ALB CNTN1 GAD2 IL6 MOG
4 behavior/neurological MP:0005386 9.83 AMPH AQP4 CNTN1 CNTNAP2 GAD2 IL6
5 respiratory system MP:0005388 9.23 ACE2 AQP4 GAD2 IL6 MUSK SRF

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Sodium citrate Approved, Investigational 68-04-2 23431961
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
3 Pharmaceutical Solutions
4 Hemostatics
5 Citrate
6 Immunoglobulins, Intravenous
7 Immunoglobulins
8 Antibodies

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Prospective Interventional Study to Investigate Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation With or Without Coagulation Factors Replacement Unknown status NCT03801135 Fibrinogen concentrate
2 International GBS Outcome Study (IGOS): A Prospective INC Study on Clinical and Biological Predictors of Disease Course and Outcome in Guillain-Barré Syndrome (GBS). Active, not recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

Organs/tissues related to Miller Fisher Syndrome:

MalaCards : Eye, Heart, Dorsal Root Ganglion, Brain, Cerebellum, T Cells, Lung

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 1271)
# Title Authors PMID Year
Pre- and postsynaptic blockade of neuromuscular transmission by Miller-Fisher syndrome IgG at mouse motor nerve terminals. 53 62
9753137 1998
Antibodies to Glycolipids in Guillain-Barré Syndrome, Miller Fisher Syndrome and Related Autoimmune Neurological Diseases. 62
36255685 2023
A case of COVID-19 with multiple cranial neuropathies. 62
33372575 2022
Neurological manifestations of COVID-19: a retrospective observational study based on 1060 patients with a narrative review. 62
36451533 2022
Miller-Fisher syndrome after first dose of Oxford/AstraZeneca coronavirus disease 2019 vaccine: a case report. 62
36384584 2022
A teenager with ophthalmoparesis and dysphagia. 62
36427894 2022
Efferent neuro-ophthalmic complications of coronavirus disease 2019. 62
36165417 2022
Miller Fisher syndrome after Pfizer BioNTech vaccine booster responsive to intravenous Ig treatment. 62
36357112 2022
Guillain-Barré syndrome from an emergency department view: how to better predict the outcome? 62
35580194 2022
Miller Fisher syndrome following COVID-19 vaccines: A scoping review. 62
35938305 2022
Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review. 62
36338884 2022
Guillain-Barré syndrome in children - High occurrence of Miller Fisher syndrome in East Asian region. 62
35906115 2022
Campylobacter jejuni and Postinfectious Autoimmune Diseases: A Proof of Concept in Glycobiology. 62
36137262 2022
Course and Treatment of a Rare Neurological Sequelae After COVID-19: Miller Fisher Syndrome. 62
36381748 2022
Miller-Fisher syndrome and Guillain-Barre syndrome overlap syndrome following inactivated COVID-19 vaccine: Case report and scope review. 62
36315834 2022
Positive anti-GQ1b Miller Fisher syndrome and Escherichia coli infection: A case report. 62
36195377 2022
Miller Fisher syndrome complicated by inappropriate secretion of antidiuretic hormone: a case report. 62
35871211 2022
A rare overlap between Miller Fisher syndrome and pure motor Guillain-Barre syndrome. 62
36201115 2022
Emphasis on the Optimal Functional Recovery Through a Structured Inpatient Rehabilitation Program Along With a Home Exercise Regime in an Individual With Miller-Fisher Syndrome: A Case Report. 62
36348871 2022
Ataxia and ophthalmoplegia: an atypical case of Miller Fisher syndrome (MFS) with anti-GAD antibody. 62
33280463 2022
Paralytic ileus as first symptom of Miller Fisher syndrome: A case report. 62
36086690 2022
Acute Isolated External Ophthalmoplegia: Think of Anti-GQ1b Antibody Syndrome. 62
36352629 2022
A Rare Presentation of a Complex Mixed Autoimmune Encephalitis Diagnosis: A Case Report and Literature Review. 62
36321035 2022
[Miller Fisher syndrome]. 62
36205161 2022
Cardiovascular Autonomic Assessment in Guillain-Barré Syndrome: A Longitudinal Study. 62
36352579 2022
Treatable Ataxias: How to Find the Needle in the Haystack? 62
36065614 2022
Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database. 62
35751472 2022
Guillain-barré syndrome without limb weakness: A rare variant with acute bulbar palsy. 62
36353017 2022
Weakness in both lower limbs for 1 week and blepharoptosis for 3 days in a boy aged 1 year and 7 months. 62
36036132 2022
Clinical Reasoning: An 8-Year-Old With Acute Onset Ataxia. 62
35970580 2022
A case of Miller Fisher syndrome with delayed onset peripheral facial nerve palsy after COVID-19 vaccination: a case report. 62
35996074 2022
Rare Etiologies in Immune-Mediated Cerebellar Ataxias: Diagnostic Challenges. 62
36138901 2022
Severe Vision Loss and Optic Disc Edema Associated With GAD-65 Antibody Positive Miller Fisher Syndrome. 62
36000786 2022
Miller Fisher syndrome associated with COVID 19. 62
36387653 2022
Acute eye movement-retained internal ophthalmoplegia in atypical Miller Fisher syndrome variants are associated with IgG anti-GQ1b antibodies. 62
35537332 2022
Miller-Fisher syndrome associated with SARS-CoV-2: a case report. 62
35240290 2022
COVID-19 Presenting As Miller Fisher Syndrome in a Patient With a History of Guillain-Barré Syndrome: A Case Report. 62
35936171 2022
[Pathophysiological and diagnostic aspects of Guillain-Barré syndrome]. 62
34998626 2022
Are Miller Fisher syndrome and CANDA due to a paranodopathy? 62
35576641 2022
Neuroimmune disorders in COVID-19. 62
35353232 2022
Serum thyroid-stimulating hormone is an independent risk factor of recurrent Guillain-Barré syndrome. 62
35342963 2022
SARS-CoV-2-associated Guillain-Barré syndrome in four patients: what do we know about pathophysiology? 62
34476752 2022
Recurrent Miller Fisher Syndrome. 62
35891880 2022
Autoimmune Cerebellar Ataxia: Etiology and Clinical Characteristics of a Case Series from China. 62
35618871 2022
Miller Fisher syndrome after COVID-19 vaccination: Case report and review of literature. 62
35608434 2022
Modified Zipper Method, a Promising Treatment Option in Severe Pediatric Immune-Mediated Neurologic Disorders. 62
35435761 2022
COVID-19-Associated Miller Fisher Syndrome With Long Latency Period: A Case Report. 62
35663687 2022
Costs of Guillain-Barré Syndrome in the Brazilian Federal District: the patients' perspective. 62
34358316 2022
Demographic, clinical, investigational characteristics of COVID-19 related Guillain-Barré syndrome with differences from typical and another virus-related Guillain-Barré syndrome. 62
35507796 2022
When your cat takes you to the ICU: Miller Fisher/ Guillain-Barré-overlap-syndrome caused by Pasteurella multocida infection resembling wound botulism. 62
35123165 2022

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

GO Terms for Miller Fisher Syndrome

Cellular components related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.64 TNF TMPRSS2 NFASC MUSK MAG CCR6
2 plasma membrane GO:0005887 9.64 TNF TMPRSS2 NFASC MUSK MAG CCR6

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gap junction assembly GO:1903598 9.67 CNTNAP2 ACE2
2 vascular endothelial growth factor production GO:0010573 9.62 TNF IL6
3 central nervous system myelin formation GO:0032289 9.56 MAG CNTN1
4 regulation of vascular endothelial growth factor production GO:0010574 9.46 IL6 AQP4
5 transmission of nerve impulse GO:0019226 9.43 NFASC MAG CNTNAP2
6 neuron projection development GO:0031175 9.23 SRF LGI1 IL6 CNTNAP2 CNTN1

Sources for Miller Fisher Syndrome

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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