MCID: MLL002
MIFTS: 43

Miller Fisher Syndrome

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Miller Fisher Syndrome

MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 74 53 58 54 43 15 17 71
Cranial Variant of Gbs 52 58
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Cranial Variant of Guillain-Barré Syndrome 52
Cranial Variant of Guillain-Barre Syndrome 58
Miller-Fisher Syndrome 52
Fisher's Syndrome 12
Fisher Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
miller fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
MeSH 43 D019846
NCIt 49 C116958
SNOMED-CT 67 1767005
ICD10 32 G61.0
MESH via Orphanet 44 D019846
ICD10 via Orphanet 33 G61.0
UMLS via Orphanet 72 C0393799
Orphanet 58 ORPHA98919
UMLS 71 C0393799

Summaries for Miller Fisher Syndrome

NIH Rare Diseases : 52 Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barre syndrome . The main features are lack of muscle coordination (ataxia ), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes . Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b ) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome. Treatment includes intravenous immunoglobulin (IVIG), plasmapheresis (a plasma exchange procedure in which the antibodies are removed from the blood) and supportive care. The prognosis is usually good, and in most cases, there is almost complete recovery within 6 months. In rare cases, the syndrome may progress and permanent neurological deficits may be present.

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of gbs, is related to guillain-barre syndrome and myasthenia gravis, and has symptoms including ophthalmoplegia and cerebellar ataxia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain, and related phenotypes are behavior/neurological and mortality/aging

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS : 53 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Wikipedia : 74 Guillain-Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the... more...

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 33.6 TNF PMP22 NFASC MAG CD40LG
2 myasthenia gravis 31.0 TNF MUSK CD40LG
3 sensory peripheral neuropathy 30.9 PMP22 MAG CD40LG
4 autoimmune peripheral neuropathy 30.7 MAG CD40LG
5 demyelinating polyneuropathy 30.6 PMP22 NFASC MAG CNTN1
6 polyneuropathy 30.6 TNF PMP22 NFASC MAG CNTN1 CD40LG
7 polyradiculoneuropathy 30.5 PMP22 NFASC MAG CNTN1
8 optic neuritis 30.5 TNF MAG AQP4
9 chlamydia pneumonia 30.4 TNF CD40LG
10 neuritis 30.3 TNF PMP22 MAG AQP4
11 multifocal motor neuropathy 30.3 GLDN CD40LG
12 optic nerve disease 30.3 TNF MAG CD40LG AQP4
13 pharyngitis 30.3 TNF MYOM2 CD40LG
14 encephalitis 30.2 TNF CNTNAP2 CD40LG AQP4 AMPH
15 internuclear ophthalmoplegia 30.2 NT5C3A AQP4
16 abducens nerve disease 30.2 NT5C3A AQP4
17 rheumatic fever 30.1 TNF MYOM2 CD40LG
18 monoclonal gammopathy of uncertain significance 30.0 TNF MYOM2 MAG CD40LG
19 cranial nerve palsy 29.8 NT5C3A CD40LG AQP4
20 autoimmune neuropathy 29.8 PMP22 NFASC MAG GLDN CNTN1 CD40LG
21 demyelinating disease 29.6 TNF PMP22 MAG CD40LG AQP4
22 neuromuscular disease 29.5 PMP22 MUSK MAG AMPH
23 peripheral nervous system disease 28.1 TNF PMP22 NT5C3A NFASC MYOM2 MUSK
24 snijders blok-fisher syndrome 12.6
25 kozlowski warren fisher syndrome 12.3
26 bickerstaff brainstem encephalitis 11.9
27 kearns-sayre syndrome 11.2
28 ataxia and polyneuropathy, adult-onset 11.2
29 neuropathy 10.7
30 ptosis 10.7
31 facial paralysis 10.6
32 foodborne botulism 10.5
33 axonal neuropathy 10.5
34 pathologic nystagmus 10.5
35 dysphagia 10.5
36 encephalopathy 10.5
37 rheumatoid vasculitis 10.5 TNF SRF
38 opportunistic bacterial infectious disease 10.5 TNF CD40LG
39 gastrointestinal tuberculosis 10.5 TNF CD40LG
40 cerebritis 10.5 TNF CD40LG
41 granulomatous hepatitis 10.4 TNF CD40LG
42 cerebral lymphoma 10.4 MAG CD40LG
43 inflammatory and toxic neuropathy 10.4 TNF PMP22
44 transient hypogammaglobulinemia 10.4 TNF CD40LG
45 postpoliomyelitis syndrome 10.4 PMP22 CD40LG
46 granulomatous dermatitis 10.4 TNF CD40LG
47 respiratory failure 10.4
48 aortitis 10.4 TNF CD40LG
49 paraneoplastic polyneuropathy 10.4 PMP22 AMPH
50 ornithosis 10.4 CD40LG ALLC

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:


ophthalmoplegia, cerebellar ataxia

MGI Mouse Phenotypes related to Miller Fisher Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 AMPH AQP4 CNTN1 CNTNAP2 GLDN MAG
2 mortality/aging MP:0010768 9.73 AMPH AQP4 CD40LG CNTN1 GLDN MUSK
3 nervous system MP:0003631 9.4 AMPH AQP4 CD40LG CNTN1 CNTNAP2 GLDN

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
3 Citrate
4 Hemostatics
5 Pharmaceutical Solutions
6 Immunoglobulins
7 Antibodies
8 Immunoglobulins, Intravenous

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Interventional Study to Investigate Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation With or Without Coagulation Factors Replacement Recruiting NCT03801135 Fibrinogen concentrate
2 International GBS Outcome Study (IGOS): A Prospective INC Study on Clinical and Biological Predictors of Disease Course and Outcome in Guillain-Barré Syndrome (GBS). Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

MalaCards organs/tissues related to Miller Fisher Syndrome:

40
Eye, Heart, Brain, Testes, Cerebellum, Lung, Bone

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 743)
# Title Authors PMID Year
1
Prediction of disease progression in Miller Fisher and overlap syndromes. 61 52
29065229 2017
2
Recurrent miller fisher: a new case report and a literature review. 52 61
28612899 2017
3
Pre- and postsynaptic blockade of neuromuscular transmission by Miller-Fisher syndrome IgG at mouse motor nerve terminals. 61 54
9753137 1998
4
Guillain-Barré syndrome: The first documented COVID-19-triggered autoimmune neurologic disease: More to come with myositis in the offing. 61
32518172 2020
5
The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. 61
32464367 2020
6
Miller-Fisher syndrome after SARS-CoV-2 infection. 61
32503084 2020
7
Neurologic aspects of covid-19: a concise review. 61
32532937 2020
8
A systematic review of neurological manifestations of SARS-CoV-2 infection: the devil is hidden in the details. 61
32503088 2020
9
Miller Fisher syndrome diagnosis and treatment in a patient with SARS-CoV-2. 61
32529516 2020
10
Diagnosis of Guillain-Barré syndrome and validation of the Brighton criteria in Malaysia. 61
32511817 2020
11
[Anti-GQ1b syndrome. A child with Miller-Fisher-Bickerstaff syndrome]. 61
32470277 2020
12
Intravenous immunoglobulin-induced aseptic meningitis in a patient with Miller Fisher syndrome. 61
32449133 2020
13
Atypical case of Miller-Fisher syndrome presenting with severe dysphagia and weight loss. 61
32467120 2020
14
COVID-19-Associated Miller Fisher Syndrome: MRI Findings. 61
32467190 2020
15
Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. 61
32303650 2020
16
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases. 61
32152553 2020
17
Cerebrospinal fluid total protein in Guillain-Barré syndrome variants: correlations with clinical category, severity, and electrophysiology. 61
31734909 2020
18
An Unusual Recurrence of Miller Fisher Syndrome: Three Times in Eight Years. 61
32110156 2020
19
Atypical Descending Paralysis in Miller Fisher Syndrome: A Rare Variant of Guillain-Barre Syndrome. 61
32274281 2020
20
Miller Fisher syndrome and Guillain-Barré syndrome: dual intervention rehabilitation of a complex patient case. 61
32149554 2020
21
Miller Fisher syndrome with bilateral vocal cord paralysis: a case report. 61
32070436 2020
22
Ophthalmic manifestations of arbovirus infections in adults. 61
31679764 2020
23
Faster Recovery of Internal Ophthalmoplegia than External Ophthalmoplegia in a Miller Fisher Variant of Guillain-Barre Syndrome. 61
32328331 2020
24
An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus in Campylobacter jejuni. 61
32508756 2020
25
An Overlapping Case of Miller Fisher Syndrome and the Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome. 61
32133309 2020
26
Miller Fisher Variant of Guillain-Barré Syndrome in a Child. 61
32435311 2020
27
Clinical characteristics and outcomes of patients with overlapping Miller Fisher syndrome and myasthenia gravis. 61
32051728 2020
28
The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review. 61
32574246 2020
29
Early electrophysiological findings in Fisher-Bickerstaff syndrome. 61
28888467 2020
30
Miller Fisher syndrome with early intracranial hypertension and delayed bilateral simultaneous facial nerve palsy: a case report. 61
31709869 2019
31
Acute vestibular syndrome associated with anti-GQ1b antibody. 61
31399495 2019
32
GQ1b-Seronegative Miller Fisher Syndrome Associated With Pembrolizumab. 61
30801443 2019
33
A rare case of Miller Fisher variant of Guillain-Barré Syndrome (GBS) induced by a checkpoint inhibitor. 61
31413049 2019
34
Miller Fisher Syndrome Following Tetanus, Diphtheria, and Pertussis (Tdap) Vaccine. 61
31512652 2019
35
Current treatment practice of Guillain-Barré syndrome. 61
31175208 2019
36
Age matters: Impact of data-driven CSF protein upper reference limits in Guillain-Barré syndrome. 61
31355312 2019
37
Pattern of Extraocular Muscle Involvements in Miller Fisher Syndrome. 61
31286701 2019
38
Co-occurrence of acute ophthalmoplegia (without ataxia) and idiopathic intracranial hypertension. 61
30280587 2019
39
Idiopathic third and sixth cranial nerve neuritis. 61
31006061 2019
40
[Miller-Fisher syndrome in a 6-year-old child with negative anti-GQ1b antibodies]. 61
31078328 2019
41
[A case of Miller Fisher syndrome with a false-positive edrophonium test]. 61
31142707 2019
42
A unicenter, prospective study of Guillain-Barré syndrome in Spain. 61
30929269 2019
43
The utility of Guillain-Barré syndrome prognostic models in Malaysian patients. 61
31001904 2019
44
A Case of Miller Fisher Syndrome. 61
30710536 2019
45
[Clinical analysis of 8 cases with anti-GQ1b antibody syndrome]. 61
31207691 2019
46
Miller Fisher syndrome mimicking botulism: Clinical and pathophysiological discussion of a case. 61
31047688 2019
47
Role of Anti-ganglioside Antibodies in the Diagnosis of Guillain-Barré Syndrome as an Alternate Investigation. 61
31312551 2019
48
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature. 61
31043165 2019
49
Clinical characterization of anti-GQ1b antibody syndrome in Korean children. 61
30642576 2019
50
A Simplified, Graded, Electrodiagnostic Criterion for Guillain-Barré Syndrome That Incorporates Sensory Nerve Conduction Studies. 61
31118437 2019

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

Pathways related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 PSENEN NFASC MAG CNTNAP2
2 11.21 TNF MAG AQP4
3 11.19 NFASC MAG CNTNAP2 CNTN1 CD40LG

GO Terms for Miller Fisher Syndrome

Cellular components related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.15 TNF ST8SIA1 PSENEN PMP22 NFASC MUSK
2 plasma membrane GO:0005886 10.03 TNF PSENEN PMP22 NFASC MUSK MAG
3 paranode region of axon GO:0033270 9.32 NFASC MAG
4 integral component of plasma membrane GO:0005887 9.23 TNF PSENEN NFASC MUSK MAG KCNH4
5 paranodal junction GO:0033010 9.16 NFASC CNTNAP2
6 compact myelin GO:0043218 8.96 PMP22 MAG

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac myofibril assembly GO:0055003 9.37 SRF MYOM2
2 negative regulation of amyloid-beta clearance GO:1900222 9.32 TNF SRF
3 clustering of voltage-gated sodium channels GO:0045162 9.26 NFASC GLDN
4 protein localization to juxtaparanode region of axon GO:0071205 9.16 NFASC CNTNAP2
5 regulation of immunoglobulin secretion GO:0051023 8.96 TNF CD40LG
6 transmission of nerve impulse GO:0019226 8.8 NFASC MAG CNTNAP2

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding involved in heterotypic cell-cell adhesion GO:0086080 8.62 NFASC GLDN

Sources for Miller Fisher Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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