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MCID: MLL002
MIFTS: 40

Miller Fisher Syndrome

Categories: Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Miller Fisher Syndrome

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MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 74 53 58 54 43 15 17 71
Cranial Variant of Gbs 52 58
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Cranial Variant of Guillain-Barré Syndrome 52
Cranial Variant of Guillain-Barre Syndrome 58
Miller-Fisher Syndrome 52
Fisher's Syndrome 12
Fisher Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
miller fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
MeSH 43 D019846
NCIt 49 C116958
SNOMED-CT 67 1767005
ICD10 32 G61.0
MESH via Orphanet 44 D019846
ICD10 via Orphanet 33 G61.0
UMLS via Orphanet 72 C0393799
Orphanet 58 ORPHA98919
UMLS 71 C0393799
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Summaries for Miller Fisher Syndrome

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NIH Rare Diseases : 52 Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barre syndrome . The main features are lack of muscle coordination (ataxia ), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes . Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b ) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome. Treatment includes intravenous immunoglobulin (IVIG), plasmapheresis (a plasma exchange procedure in which the antibodies are removed from the blood) and supportive care. The prognosis is usually good, and in most cases, there is almost complete recovery within 6 months. In rare cases, the syndrome may progress and permanent neurological deficits may be present.

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of gbs, is related to guillain-barre syndrome and neuritis, and has symptoms including ophthalmoplegia and cerebellar ataxia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain.

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS : 53 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Wikipedia : 74 Guillain-Barre syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the... more...

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Related Diseases for Miller Fisher Syndrome

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Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 34.2 TNF PMP22 CD40LG
2 neuritis 31.2 TNF PMP22 MAG
3 autoimmune peripheral neuropathy 30.6 NFASC MAG
4 chlamydia pneumonia 30.6 TNF CD40LG
5 monoclonal gammopathy of uncertain significance 30.6 TNF MAG CD40LG
6 demyelinating polyneuropathy 30.5 PMP22 NFASC MAG CNTN1
7 polyneuropathy 30.4 TNF PMP22 NFASC MAG CNTN1 CD40LG
8 multifocal motor neuropathy 30.2 GLDN CD40LG
9 internuclear ophthalmoplegia 30.2 NT5C3A HECTD4
10 cranial nerve palsy 30.2 NT5C3A CD40LG
11 polyradiculoneuropathy 30.1 PMP22 NFASC MAG CNTN1 CD40LG
12 sensory peripheral neuropathy 30.0 PMP22 MAG HECTD4 CD40LG
13 demyelinating disease 29.9 TNF PMP22 MAG IL23A CD40LG
14 dissociated nystagmus 29.8 NT5C3A HECTD4
15 autoimmune neuropathy 29.6 PMP22 NFASC MAG GLDN CNTN1 CD40LG
16 peripheral nervous system disease 29.3 TNF PMP22 NFASC MUSK MAG HECTD4
17 neuromuscular disease 28.1 TNF PMP22 MUSK MAG HECTD4 CD40LG
18 snijders blok-fisher syndrome 12.5
19 kozlowski warren fisher syndrome 12.3
20 bickerstaff brainstem encephalitis 11.8
21 postaxial acrofacial dysostosis 11.5
22 kearns-sayre syndrome 11.2
23 ataxia and polyneuropathy, adult-onset 11.1
24 encephalitis 10.8
25 neuropathy 10.7
26 ptosis 10.7
27 facial paralysis 10.6
28 myasthenia gravis 10.5
29 axonal neuropathy 10.5
30 rheumatoid vasculitis 10.5 TNF SRF
31 optic nerve disease 10.5
32 pathologic nystagmus 10.5
33 gastrointestinal tuberculosis 10.5 TNF CD40LG
34 osteosclerotic myeloma 10.5 MAG CD40LG
35 transient hypogammaglobulinemia 10.5 TNF CD40LG
36 aortitis 10.5 TNF CD40LG
37 inflammatory and toxic neuropathy 10.4 PMP22 CD40LG
38 aceruloplasminemia 10.4
39 foodborne botulism 10.4
40 optic neuritis 10.4
41 encephalopathy 10.4
42 granulomatous dermatitis 10.4 TNF CD40LG
43 abdominal tuberculosis 10.4 TNF CD40LG
44 postpoliomyelitis syndrome 10.4 PMP22 CD40LG
45 blastomycosis 10.4 TNF CD40LG
46 scleral disease 10.4 TNF CD40LG
47 waldenstroem's macroglobulinemia 10.4 MAG CD40LG
48 lung abscess 10.4 TNF CD40LG
49 ornithosis 10.4 CD40LG ALLC
50 pustulosis palmaris et plantaris 10.4 TNF CD40LG

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome
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Symptoms & Phenotypes for Miller Fisher Syndrome

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UMLS symptoms related to Miller Fisher Syndrome:


ophthalmoplegia, cerebellar ataxia
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Drugs & Therapeutics for Miller Fisher Syndrome

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Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
3
Calcium Approved, Nutraceutical 7440-70-2 271
4 Hemostatics
5 Citrate
6 Chelating Agents
7 Pharmaceutical Solutions
8 Anticoagulants
9 Calcium, Dietary
10 Coagulants
11 Immunoglobulins
12 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Interventional Study to Investigate Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation With or Without Coagulation Factors Replacement Recruiting NCT03801135 Fibrinogen concentrate
2 International GBS Outcome Study (IGOS): A Prospective INC Study on Clinical and Biological Predictors of Disease Course and Outcome in Guillain-Barré Syndrome (GBS). Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

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Genetic Tests for Miller Fisher Syndrome

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Anatomical Context for Miller Fisher Syndrome

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MalaCards organs/tissues related to Miller Fisher Syndrome:

40
Eye, Heart, Brain, Lung, Bone, B Cells, Thymus
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Publications for Miller Fisher Syndrome

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Articles related to Miller Fisher Syndrome:

(show top 50) (show all 718)
# Title Authors PMID Year
1
Prediction of disease progression in Miller Fisher and overlap syndromes. 61 52
29065229 2017
2
Recurrent miller fisher: a new case report and a literature review. 61 52
28612899 2017
3
Pre- and postsynaptic blockade of neuromuscular transmission by Miller-Fisher syndrome IgG at mouse motor nerve terminals. 54 61
9753137 1998
4
Ophthalmic manifestations of arbovirus infections in adults. 61
31679764 2020
5
Cerebrospinal fluid total protein in Guillain-Barré syndrome variants: correlations with clinical category, severity, and electrophysiology. 61
31734909 2019
6
Miller Fisher syndrome with early intracranial hypertension and delayed bilateral simultaneous facial nerve palsy: a case report. 61
31709869 2019
7
GQ1b-Seronegative Miller Fisher Syndrome Associated With Pembrolizumab. 61
30801443 2019
8
Acute vestibular syndrome associated with anti-GQ1b antibody. 61
31399495 2019
9
A rare case of Miller Fisher variant of Guillain-Barré Syndrome (GBS) induced by a checkpoint inhibitor. 61
31413049 2019
10
Current treatment practice of Guillain-Barré syndrome. 61
31175208 2019
11
Miller Fisher Syndrome Following Tetanus, Diphtheria, and Pertussis (Tdap) Vaccine. 61
31512652 2019
12
Age matters: Impact of data-driven CSF protein upper reference limits in Guillain-Barré syndrome. 61
31355312 2019
13
Pattern of Extraocular Muscle Involvements in Miller Fisher Syndrome. 61
31286701 2019
14
Co-occurrence of acute ophthalmoplegia (without ataxia) and idiopathic intracranial hypertension. 61
30280587 2019
15
Idiopathic third and sixth cranial nerve neuritis. 61
31006061 2019
16
[Miller-Fisher syndrome in a 6-year-old child with negative anti-GQ1b antibodies]. 61
31078328 2019
17
[A case of Miller Fisher syndrome with a false-positive edrophonium test]. 61
31142707 2019
18
A Case of Miller Fisher Syndrome. 61
30710536 2019
19
Miller Fisher syndrome mimicking botulism: Clinical and pathophysiological discussion of a case. 61
31047688 2019
20
[Clinical analysis of 8 cases with anti-GQ1b antibody syndrome]. 61
31207691 2019
21
A unicenter, prospective study of Guillain-Barré syndrome in Spain. 61
30929269 2019
22
The utility of Guillain-Barré syndrome prognostic models in Malaysian patients. 61
31001904 2019
23
A Simplified, Graded, Electrodiagnostic Criterion for Guillain-Barré Syndrome That Incorporates Sensory Nerve Conduction Studies. 61
31118437 2019
24
Role of Anti-ganglioside Antibodies in the Diagnosis of Guillain-Barré Syndrome as an Alternate Investigation. 61
31312551 2019
25
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature. 61
31043165 2019
26
Clinical characterization of anti-GQ1b antibody syndrome in Korean children. 61
30642576 2019
27
Miller Fisher Syndrome revealing a lung carcinoma: Paraneoplastic origin of Miller Fisher Syndrome? 61
30929876 2019
28
[Acute Juvenile Ophthalmoplegia (Miller Fisher Syndrome): an Interesting Case]. 61
30999339 2019
29
Guillain-Barré Syndrome and Its Variants: Clinical Course and Prognostic Factors. 61
30911241 2019
30
A rare mimic of acute stroke: rapidly progressing Miller-Fisher Syndrome to acute motor and sensory axonal neuropathy variant of Guillain-Barre Syndrome. 61
30936342 2019
31
Clinical spectrum of the anti-GQ1b antibody syndrome: a case series of eight patients. 61
30747336 2019
32
Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens. 61
30862994 2019
33
Atypical clinical manifestations of Miller Fisher syndrome. 61
30232672 2019
34
Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barré syndrome in children: Report of two cases and review of the literature. 61
30502045 2019
35
Ophthalmoplegia Due to Miller Fisher Syndrome in a Patient With Myasthenia Gravis. 61
31456730 2019
36
Guillain-Barré syndrome subtypes: A clinical electrophysiological study of 100 patients. 61
30442448 2019
37
Two Cases of Guillain-Barré Syndrome Variants Presenting With Dysautonomia. 61
31259196 2019
38
Whole-genome comparative analysis of Campylobacter jejuni strains isolated from patients with diarrhea in northeastern Poland. 61
31244901 2019
39
Clinical relevance of serum antibodies to GD1b in immune-mediated neuropathies. 61
30101437 2018
40
Area postrema syndrome as frequent feature of Bickerstaff brainstem encephalitis. 61
30564620 2018
41
Immune-mediated neurological manifestations of dengue virus- a study of clinico-investigational variability, predictors of neuraxial involvement, and outcome with the role of immunomodulation. 61
30504556 2018
42
One-sided triangle: A case of double vision. 61
29920248 2018
43
Varied antibody reactivities and clinical relevance in anti-GQ1b antibody-related diseases. 61
30246056 2018
44
Regional variation of Guillain-Barré syndrome. 61
30247567 2018
45
Creutzfeldt-Jakob disease with unusual presentation of peripheral neuropathy and ophthalmoplegia. 61
30319957 2018
46
Bilateral Sixth Nerve Palsy and Nasal Voice in Two Sisters as a Variant of Guillan-Barré Syndrome. 61
30258478 2018
47
Miller Fisher Syndrome Associated With Immunotherapy for Metastatic Melanoma. 61
30245770 2018
48
Miller Fisher Syndrome Mimicking Tolosa-Hunt Syndrome. 61
29709941 2018
49
A Case Report of Overlapping Miller Fisher Syndrome, Guillain-Barré Syndrome, and the Bickerstaff Brainstem Encephalitis. 61
29953036 2018
50
Clinical relevance of terminal Schwann cells: An overlooked component of the neuromuscular junction. 61
29536564 2018
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Variations for Miller Fisher Syndrome

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Expression for Miller Fisher Syndrome

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Search GEO for disease gene expression data for Miller Fisher Syndrome.
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Pathways for Miller Fisher Syndrome

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Pathways related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell adhesion molecules (CAMs) 36
11.09 NFASC MAG CNTN1 CD40LG
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GO Terms for Miller Fisher Syndrome

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Cellular components related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 TNF SIGLEC7 PSENEN PMP22 NFASC MUSK
2 paranode region of axon GO:0033270 9.26 NFASC MAG
3 integral component of plasma membrane GO:0005887 9.23 TNF SIGLEC7 PSENEN NFASC MUSK MAG
4 compact myelin GO:0043218 8.96 PMP22 MAG

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmission of nerve impulse GO:0019226 9.26 NFASC MAG
2 negative regulation of amyloid-beta clearance GO:1900222 9.16 TNF SRF
3 clustering of voltage-gated sodium channels GO:0045162 8.96 NFASC GLDN
4 regulation of immunoglobulin secretion GO:0051023 8.62 TNF CD40LG

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding involved in heterotypic cell-cell adhesion GO:0086080 8.62 NFASC GLDN
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Sources for Miller Fisher Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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