MCID: MLL002
MIFTS: 42

Miller Fisher Syndrome

Categories: Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Miller Fisher Syndrome

MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 76 54 55 44 15 73
Cranial Variant of Guillain-Barré Syndrome 53 59
Miller-Fisher Syndrome 53 59
Cranial Variant of Gbs 53 59
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Fisher's Syndrome 12
Fisher Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
miller-fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
ICD10 33 G61.0
MeSH 44 D019846
NCIt 50 C116958
Orphanet 59 ORPHA98919
MESH via Orphanet 45 D019846
UMLS via Orphanet 74 C0393799
ICD10 via Orphanet 34 G61.0
UMLS 73 C0393799

Summaries for Miller Fisher Syndrome

NIH Rare Diseases : 53 Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barré syndrome. The main features are lack of muscle coordination (ataxia), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes. Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome. Treatment includes intravenous immunoglobulin (IVIG), plasmapheresis (a plasma exchange procedure in which the antibodies are removed from the blood) and supportive care. The prognosis is usually good, and in most cases, there is almost complete recovery within 6 months. In rare cases, the syndrome may progress and permanent neurological deficits may be present.

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to guillain-barre syndrome and optic neuritis, and has symptoms including cerebellar ataxia and ophthalmoplegia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain.

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS : 54 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Wikipedia : 76 Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the... more...

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 33.8 CD40LG TNF
2 optic neuritis 30.8 MAG TNF
3 neuritis 30.7 MAG TNF
4 q fever 30.7 CD40LG TNF
5 peripheral nervous system disease 30.3 CD40LG MAG
6 meningitis 29.3 CD40LG TNF
7 kozlowski warren fisher syndrome 12.0
8 bickerstaff brainstem encephalitis 11.5
9 trench fever 10.6 CD40LG TNF
10 encephalitozoonosis 10.6 CD40LG TNF
11 rheumatoid lung disease 10.6 CD40LG TNF
12 central nervous system vasculitis 10.6 CD40LG TNF
13 primary systemic mycosis 10.6 CD40LG TNF
14 jejunoileitis 10.6 CD40LG TNF
15 acute salpingitis 10.6 CD40LG TNF
16 coccidiosis 10.6 CD40LG TNF
17 hemorrhagic fever 10.6 CD40LG TNF
18 pneumocystosis 10.6 CD40LG TNF
19 streptococcal meningitis 10.6 CD40LG TNF
20 spinal cord disease 10.6 CD40LG TNF
21 pustulosis palmaris et plantaris 10.6 CD40LG TNF
22 panuveitis 10.6 CD40LG TNF
23 scrub typhus 10.6 CD40LG TNF
24 lichen disease 10.6 CD40LG TNF
25 middle ear disease 10.6 CD40LG TNF
26 plasmodium vivax malaria 10.6 CD40LG TNF
27 hepatitis e 10.6 CD40LG TNF
28 progressive multifocal leukoencephalopathy 10.6 CD40LG TNF
29 commensal bacterial infectious disease 10.6 CD40LG TNF
30 churg-strauss syndrome 10.6 CD40LG TNF
31 hypersensitivity reaction type iv disease 10.6 CD40LG TNF
32 hemorrhagic fever with renal syndrome 10.6 CD40LG TNF
33 rheumatic fever 10.6 CD40LG TNF
34 extrinsic cardiomyopathy 10.6 CD40LG TNF
35 lymph node disease 10.6 CD40LG TNF
36 exanthem 10.6 CD40LG TNF
37 cogan syndrome 10.5 CD40LG TNF
38 idiopathic neutropenia 10.5 CD40LG TNF
39 chikungunya 10.5 CD40LG TNF
40 cutaneous lupus erythematosus 10.5 CD40LG TNF
41 mixed connective tissue disease 10.5 CD40LG TNF
42 legionellosis 10.5 CD40LG TNF
43 echinococcosis 10.5 CD40LG TNF
44 leptospirosis 10.5 CD40LG TNF
45 hepatitis a 10.5 CD40LG TNF
46 brucellosis 10.5 CD40LG TNF
47 mononeuritis multiplex 10.5 CD40LG MAG
48 parasitic helminthiasis infectious disease 10.5 CD40LG TNF
49 mononeuritis of upper limb and mononeuritis multiplex 10.5 CD40LG MAG
50 upper respiratory tract disease 10.5 CD40LG TNF

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:


cerebellar ataxia, ophthalmoplegia

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
2 International Guillain-Barré Syndrome Outcome Study Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

MalaCards organs/tissues related to Miller Fisher Syndrome:

41
Eye, Heart, Brain, Dorsal Root Ganglion, B Cells, Lung, Testes

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 290)
# Title Authors Year
1
Miller Fisher Syndrome ( 29939539 )
2018
2
The Differential Diagnosis of Acute Onset Truncal Ataxia: The Importance of Dysgeusia in Miller Fisher Syndrome. ( 29491292 )
2018
3
The Role of Botulinum Toxin in the Management of Ophthalmoplegia Secondary to Miller Fisher Syndrome. ( 29796048 )
2018
4
Anti-ganglioside complex antibody profiles in a recurrent complicated case of GQ1b-seronegative miller fisher syndrome and Bickerstaff brainstem encephalitis: a case report. ( 29792178 )
2018
5
Headache and Ophthalmoparesis: Case Report of an "Atypical" Incomplete Miller-Fisher Syndrome. ( 29878345 )
2018
6
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
7
Bulbar paralysis associated with Miller-Fisher syndrome and its overlaps in Chinese patients. ( 29124441 )
2018
8
A Case Report of Overlapping Miller Fisher Syndrome, Guillain-BarrAc Syndrome, and the Bickerstaff Brainstem Encephalitis. ( 29953036 )
2018
9
Acute Cerebellar Ataxia Associated with Anti-glutamic Acid Decarboxylase Antibodies Mimicking Miller Fisher Syndrome. ( 29093402 )
2018
10
Miller-Fisher Syndrome With Botulism Toxin Ingestion: The Ultimate Descending Paralysis. ( 29465619 )
2018
11
A Case of Miller Fisher Syndrome Mimicking Tolosa-Hunt Syndrome. ( 29709941 )
2018
12
Miller-Fisher syndrome complicated by Bickerstaff brainstem encephalitis: A case report. ( 29489680 )
2018
13
MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. ( 28209311 )
2017
14
A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence? ( 28090073 )
2017
15
Unilateral Oculomotor Nerve Palsy Following Campylobacter Infection: A Mild Form of Miller Fisher Syndrome without Ataxia. ( 28943568 )
2017
16
A Case of Miller Fisher Syndrome and Literature Review. ( 28367386 )
2017
17
Incomplete Miller-Fisher Syndrome with Advanced Stage Burkitt Lymphoma. ( 28601853 )
2017
18
Miller Fisher syndrome with sinus arrest. ( 29109855 )
2017
19
Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. ( 28067631 )
2017
20
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. ( 29390338 )
2017
21
Miller-Fisher syndrome after coronary artery bypass surgery. ( 29297541 )
2017
22
Multiple cranial nerve neuropathies, ataxia and, areflexia: Miller Fisher syndrome in a child and review. ( 28214063 )
2017
23
Overlap of Myasthenia Gravis and Miller Fisher Syndrome. ( 27432103 )
2016
24
Takotsubo cardiomyopathy associated with Miller-Fisher syndrome. ( 28040387 )
2016
25
A case of miller fisher syndrome associated with preceding herpes zoster ophthalmicus. ( 27875624 )
2016
26
An unusual presentation of Miller Fisher syndrome with optic neuropathy. ( 27554001 )
2016
27
Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology? ( 27239355 )
2016
28
Pediatric Miller Fisher Syndrome Complicating an Epstein-Barr Virus Infection. ( 27460528 )
2016
29
An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. ( 27597525 )
2016
30
Miller Fisher syndrome. ( 27737870 )
2016
31
Recurrent Guillain-BarrAc syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis. ( 27084218 )
2016
32
Posterior reversible encephalopathy syndrome following immunoglobulin therapy in a patient with Miller-Fisher syndrome. ( 26929465 )
2016
33
Miller Fisher syndrome presenting as palate paralysis. ( 27609285 )
2016
34
Miller Fisher Syndrome: A Case Report Highlighting Heterogeneity of Clinical Features and Focused Differential Diagnosis. ( 27437164 )
2016
35
An Overlapping Case of Miller Fisher Syndrome, Bickerstaff's Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome. ( 27974981 )
2016
36
Late Presentation of Ataxia, Areflexia, and Electrophysiological Abnormalities as Part of Miller Fisher Syndrome: Case Report. ( 27928406 )
2016
37
Clinical Features of Miller-Fisher Syndrome in Pregnancy. ( 26697248 )
2015
38
Novel Variant of Miller Fisher Syndrome Occurring With Tumor Necrosis Factor I+ Antagonist Therapy. ( 26551961 )
2015
39
Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis. ( 25890931 )
2015
40
Neuro-ophthalmological manifestations in three cases of Miller Fisher syndrome and a brief review of literature. ( 26588640 )
2015
41
A case of Miller Fisher syndrome during preoperative chemotherapy for breast cancer. ( 26629243 )
2015
42
Papilledema in an otherwise clinically typical case of Miller Fisher syndrome. ( 26455984 )
2015
43
Delayed facial palsy in Miller Fisher syndrome. ( 26277343 )
2015
44
Miller-Fisher Syndrome: Is the ataxia central or peripheral? ( 26331046 )
2015
45
Miller-Fisher syndrome associated with unilateral cerebral white matter lesions. ( 26377988 )
2015
46
Atypical Miller Fisher Syndrome with Anisocoria and Rapidly Fluctuating Pupillary Diameter. ( 26380131 )
2015
47
False-Positive Serum Botulism Bioassay in Miller-Fisher Syndrome. ( 26301377 )
2015
48
Recurrent pediatric miller fisher syndrome. ( 25160556 )
2014
49
Total internal and external ophthalmoplegia as presenting symptoms of Miller Fisher syndrome. ( 25121494 )
2014
50
Taste impairment in Miller Fisher syndrome. ( 25116259 )
2014

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

GO Terms for Miller Fisher Syndrome

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 CD40LG TNF

Sources for Miller Fisher Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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