MCID: MTN002
MIFTS: 35

Mite Infestation

Categories: Infectious diseases

Aliases & Classifications for Mite Infestation

MalaCards integrated aliases for Mite Infestation:

Name: Mite Infestation 12 15
Mite Infestations 44 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7894
ICD9CM 34 133
MeSH 44 D008924
SNOMED-CT 67 78166003
ICD10 32 B88.9
UMLS 71 C0026229

Summaries for Mite Infestation

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.

MalaCards based summary : Mite Infestation, also known as mite infestations, is related to scabies and seborrheic dermatitis. An important gene associated with Mite Infestation is CFTR (CF Transmembrane Conductance Regulator), and among its related pathways/superpathways are Innate Immune System and Th17 cell differentiation. The drugs Ethanol and Benzyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include skin and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mite Infestation

Diseases related to Mite Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 scabies 32.2 IL31 CD4 AADACL3
2 seborrheic dermatitis 29.6 FLG CD4 CD1B CD1A
3 dermatitis 29.5 IL5 IL4 IL31 IL13 FLG CD4
4 urticaria 29.4 IL5 IL4 IL31 IL13
5 allergic disease 29.3 TNFRSF8 IL5 IL4 IL13
6 psoriasis 28.9 IL5 IL4 IL31 IL13 FLG CD4
7 dermatitis, atopic 28.7 TNFRSF8 IL5 IL4 IL31 IL13 FLG
8 skin disease 28.2 TNFRSF8 IL5 IL4 IL31 IL13 FLG
9 demodicidosis 11.3
10 trombiculiasis 11.2
11 miliaria rubra 10.4 IL31 CFTR
12 american histoplasmosis 10.4 TNFRSF8 CD4
13 transient arthritis 10.3 FLG CD4
14 parapsoriasis 10.3 TNFRSF8 CD4
15 orbital cellulitis 10.3 TNFRSF8 CD4
16 acute orbital inflammation 10.3 TNFRSF8 CD4
17 cystoisosporiasis 10.3 MT-CO1 CD4
18 follicular mucinosis 10.3 TNFRSF8 CD4
19 epidermolysis bullosa pruriginosa 10.3 IL31 FLG
20 cerebral lymphoma 10.3 TNFRSF8 CD4
21 chronic inducible urticaria 10.3 IL5 IL31
22 reticulum cell sarcoma 10.3 TNFRSF8 CD4
23 cat-scratch disease 10.3 TNFRSF8 CD4
24 tinea corporis 10.3 IL31 FLG AADACL3
25 microsporidiosis 10.3 DEFA1 CD4
26 mononeuritis multiplex 10.2 IL5 CD4
27 norwegian scabies 10.2 IL5 CD4 AADACL3
28 bell's palsy 10.2 DEFA1 CD4
29 keratosis 10.2
30 skin sarcoidosis 10.2 CD4 CD1B
31 snail allergy 10.2 GHITM FLG
32 metal allergy 10.2 IL4 CD4
33 ophthalmomyiasis 10.2 MT-CO1 CD4
34 blepharoconjunctivitis 10.2 IL4 CD4
35 bartonellosis 10.2 TNFRSF8 MT-CO1 CD4
36 penis squamous cell carcinoma 10.2 COL17A1 CD4
37 pleural empyema 10.2 TNFRSF8 CD4
38 granulomatous dermatitis 10.1 CD4 CD1B
39 dendritic cell thymoma 10.1 CD4 CD1A
40 acute asthma 10.1 IL5 IL4
41 enterobiasis 10.1 MT-CO1 IL4
42 orofacial granulomatosis 10.1 IL4 FLG
43 retinitis pigmentosa 46 10.1 IL4 CD4
44 atopic keratoconjunctivitis 10.1 IL5 IL4
45 cow milk allergy 10.1 IL5 IL4
46 exanthem 10.1
47 eye disease 10.1
48 blepharitis 10.1
49 alopecia 10.1
50 oral hairy leukoplakia 10.1 CD4 CD1A

Graphical network of the top 20 diseases related to Mite Infestation:



Diseases related to Mite Infestation

Symptoms & Phenotypes for Mite Infestation

GenomeRNAi Phenotypes related to Mite Infestation according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.53 TNFRSF8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.53 IL13
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.53 IL13
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.53 TNFRSF8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.53 DEFA1 DEFA1B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.53 TNFRSF8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.53 TNFRSF8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.53 DEFA1 DEFA1B
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.53 TNFRSF8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-39 9.53 IL13
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.53 DEFA1 DEFA1B
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.53 TNFRSF8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.53 TNFRSF8

Drugs & Therapeutics for Mite Infestation

Drugs for Mite Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2 64-17-5 702
2
Benzyl alcohol Approved Phase 2 100-51-6 244
3 Anesthetics Phase 2
4 Anesthetics, Local Phase 2
5 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Multicenter, Vehicle-controlled Study of the Efficacy and Safety of Abametapir Lotion 0.74% Administered for the Treatment of Head Lice Infestation Completed NCT02062060 Phase 3 Abametapir Lotion 0.74% w/w;Vehicle Lotion
2 A Randomized, Double-Blind, Multicenter, Vehicle-Controlled Study of the Efficacy and Safety of Abametapir Lotion 0.74% Administered for the Treatment of Head Lice Infestation Completed NCT02060903 Phase 3 Abametapir Lotion 0.74% w/w;Vehicle Lotion
3 A Pediatric Safety and Pharmacokinetic Study of Ha44 Gel Administered Topically for the Treatment of Head Lice Infestation Completed NCT02010333 Phase 2 Ha44 Gel 0.74% w/w
4 A Randomised, Double-Blind, Vehicle-Controlled Study of Ovicidal Efficacy and Safety of Abametapir 0.74% Administered for the Treatment of Head Lice Infestation Completed NCT02097485 Phase 2 Abametapir Lotion 0.74% w/w;Vehicle Lotion
5 A Safety and Pharmacokinetic Study of Ha44 Gel Administered Topically Under Maximal Use Conditions for the Treatment of Head Lice Infestation. Completed NCT01907490 Phase 2 Ha44 Gel

Search NIH Clinical Center for Mite Infestation

Cochrane evidence based reviews: mite infestations

Genetic Tests for Mite Infestation

Anatomical Context for Mite Infestation

MalaCards organs/tissues related to Mite Infestation:

40
Skin, Eye

Publications for Mite Infestation

Articles related to Mite Infestation:

(show top 50) (show all 511)
# Title Authors PMID Year
1
Banks Grass Mite (Acari: Tetranychidae) Suppression May Add to the Benefit of Drought-Tolerant Corn Hybrids Exposed to Water Stress. 61
33236041 2021
2
Prevalence of Ocular Demodex Infestation in Children: An Epidemiological Survey in South China. 61
32443007 2021
3
Successful treatment of otodemodicosis due to Demodex cati with sarolaner/selamectin topical solution in a cat. 61
33598306 2021
4
Dynamics of limited neoplastic growth on Pongamia pinnata (L.) (Fabaceae) leaf, induced by Aceria pongamiae (Acari: Eriophyidae). 61
33386069 2021
5
Plant-Pathogen Interactions: Broad Mite (Polyphagotarsonemus latus)-Induced Proteomic Changes in Chili Pepper Plant (Capsicum frutescens). 61
32780627 2020
6
Selective Breeding for Low and High Varroa destructor Growth in Honey Bee (Apis mellifera) Colonies: Initial Results of Two Generations. 61
33291568 2020
7
New insights into the use of a mite count reduction test for the detection of therapeutic acaricide efficacy in Psoroptes ovis in cattle. 61
32979706 2020
8
Purification and Chemical Characterization of a Potent Acaricide and a Closely Related Inactive Metabolite Produced by Eurotium rubrum C47. 61
33316875 2020
9
Association between Demodex folliculorum and Metabolic Syndrome. 61
33017081 2020
10
Investigation of a gamasid mite infestation in a UK textile mill caused by Dermanyssus gallinae (DeGeer, 1778) (Mesostigmata: Dermanyssidae) special lineage L1. 61
32442496 2020
11
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. 61
33017398 2020
12
Evidence of vector borne transmission of Salmonella enterica enterica serovar Gallinarum and fowl typhoid disease mediated by the poultry red mite, Dermanyssus gallinae (De Geer, 1778). 61
33054854 2020
13
Efficacy of orally and topically administered fluralaner (Bravecto®) for treatment of client-owned dogs with sarcoptic mange under field conditions. 61
33069261 2020
14
Population abundance of Varroa destructor and its effects on Apis mellifera scutellata colonies in Kenya. 61
32990837 2020
15
A review: application of remote sensing as a promising strategy for insect pests and diseases management. 61
32564316 2020
16
Interactions with ectoparasitic mites induce host metabolic and immune responses in flies at the expense of reproduction-associated factors. 61
32498733 2020
17
Inventory of Varroa destructor susceptibility to amitraz and tau-fluvalinate in France. 61
32809187 2020
18
Evaluation of Traits for the Selection of Apis Mellifera for Resistance against Varroa Destructor. 61
32927627 2020
19
Tracking Red Palm Mite Damage in the Western Hemisphere Invasion with Landsat Remote Sensing Data. 61
32932932 2020
20
Demodex Species Frequency and Risk Factors in Patients With Rheumatoid Arthritis. 61
33458661 2020
21
Molecular Assessment of Genes Linked to Immune Response Traits of Honey Bees in Conventional and Organically Managed Apiaries. 61
32957431 2020
22
Demodex-Mite Infestation in Cilia and its Association With Ocular Surface Parameters in Japanese Volunteers. 61
31517735 2020
23
Non-Classic (Surrepticius) Scabies Presenting as Erythematous Painful Palmar Pustules in an Octagenarian. 61
32905381 2020
24
Biological control of mites by xerophile Eurotium species isolated from the surface of dry cured ham and dry beef cecina. 61
32869458 2020
25
Transcriptional and metabolite analysis reveal a shift in direct and indirect defences in response to spider-mite infestation in cucumber (Cucumis sativus). 61
32306368 2020
26
Correction to: Transcriptional and metabolite analysis reveal a shift in direct and indirect defences in response to spider‑mite infestation in cucumber (Cucumis sativus). 61
32350663 2020
27
Prevalence of poultry red mite (Dermanyssus gallinae) in Korean layer farms and the presence of avian pathogens in the mite. 61
32435982 2020
28
Otodectes cynotis in urban and peri-urban semi-arid areas: a widespread parasite in the cat population. 61
32508428 2020
29
Phytochemical analysis of mite-infested tea leaves of Darjeeling Hills, India. 61
31749250 2020
30
Parasitic mites alter chicken behaviour and negatively impact animal welfare. 61
32427882 2020
31
Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome? 61
32275797 2020
32
Range expansion of the tracheal mite Acarapis woodi (Acari: Tarsonemidae) among Japanese honey bee, Apis cerana japonica, in Japan. 61
32253641 2020
33
Resistance of some commercial walnut cultivars and genotypes to Aceria tristriata (Nalepa) (Acari: Eriophyidae) and its correlation with some plant features. 61
31489761 2020
34
Case for diagnosis. Erythematous and pruritic papules on forearms. 61
32171542 2020
35
Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations. 61
32351804 2020
36
Mold mite infestation in toenail dermatophytoma with pustular psoriasis. 61
32077586 2020
37
Kinome Analysis of Honeybee (Apis mellifera L.) Dark-Eyed Pupae Identifies Biomarkers and Mechanisms of Tolerance to Varroa Mite Infestation. 61
32034205 2020
38
Storage Mite Infestation of Dry-Stored Food Products and Its Relation to Human Intestinal Acariasis in the City of Minia, Egypt. 61
31742345 2020
39
Honey Bee Suppresses the Parasitic Mite Vitellogenin by Antimicrobial Peptide. 61
32523577 2020
40
Combined transcriptome and metabolome analysis identifies defence responses in spider mite-infested pepper (Capsicum annuum). 61
31557301 2020
41
Comparative transcriptome provides molecular insight into defense-associated mechanisms against spider mite in resistant and susceptible common bean cultivars. 61
32017794 2020
42
Parasitic Mite Fauna in Asian Poultry Farming Systems. 61
32733926 2020
43
Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation. 61
31817840 2019
44
Bird mite infestation masquerading as allergic dermatitis. 61
30931526 2019
45
Molecular characterization and genetic diversity of Ornithonyssus sylviarum in chickens (Gallus gallus) from Hainan Island, China. 61
31753001 2019
46
Ketalization of 2-heptanone to prolong its activity as mite repellant for the protection of honey bees. 61
31259414 2019
47
A vaccinology Approach to the Identification and Characterization of Dermanyssus Gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations. 61
31756972 2019
48
Environmental variation mediates the prevalence and co-occurrence of parasites in the common lizard, Zootoca vivipara. 61
31640667 2019
49
The Presence of Demodex Mites in Patients with Dermatologic Symptoms of the Face 61
31502805 2019
50
Quill mite infestation of rock ptarmigan Lagopus muta (Aves: Phasianidae) in relation to year and host age, sex, body condition, and density. 61
31278517 2019

Variations for Mite Infestation

Expression for Mite Infestation

Search GEO for disease gene expression data for Mite Infestation.

Pathways for Mite Infestation

Pathways related to Mite Infestation according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TNFRSF8 PGLYRP1 IL5 IL4 IL31 IL13
2
Show member pathways
12.38 IL5 IL4 IL13 CD4
3
Show member pathways
12.13 IL5 IL4 IL13 CFTR
4
Show member pathways
12.11 PGLYRP1 DEFA1B DEFA1 CD4
5 11.76 IL5 IL4 CD4
6 11.6 IL5 IL4 IL13
7 11.55 IL5 IL4 CD4 CD1B CD1A
8 11.53 IL5 IL4 IL13 CD4
9 11.43 IL5 IL4 IL13
10 11.09 IL5 IL4 IL13
11 10.96 IL5 IL4 IL13
12 10.72 IL5 IL4 IL13 CD4
13 10.68 IL5 IL4 IL31 IL13 CD4
14 10.51 IL5 IL4 IL13

GO Terms for Mite Infestation

Cellular components related to Mite Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 IL5 IL4 IL31 IL13 DEFA1B DEFA1

Biological processes related to Mite Infestation according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.8 IL4 COL17A1 CD1B CD1A
2 defense response to Gram-positive bacterium GO:0050830 9.76 PGLYRP1 DEFA1B DEFA1
3 defense response to Gram-negative bacterium GO:0050829 9.73 DEFA1B DEFA1 CD4
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.69 PGLYRP1 DEFA1B DEFA1
5 cytokine-mediated signaling pathway GO:0019221 9.65 IL5 IL4 IL31 IL13 CD4
6 antimicrobial humoral response GO:0019730 9.63 PGLYRP1 DEFA1B DEFA1
7 macrophage activation GO:0042116 9.58 IL4 IL13
8 positive regulation of B cell proliferation GO:0030890 9.58 IL5 IL4 IL13
9 T cell chemotaxis GO:0010818 9.57 DEFA1B DEFA1
10 killing by host of symbiont cells GO:0051873 9.55 DEFA1B DEFA1
11 membrane disruption in other organism GO:0051673 9.54 DEFA1B DEFA1
12 killing of cells of other organism GO:0031640 9.54 PGLYRP1 DEFA1B DEFA1
13 positive regulation of mast cell degranulation GO:0043306 9.52 IL4 IL13
14 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.48 CD1B CD1A
15 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.43 CD1B CD1A
16 innate immune response in mucosa GO:0002227 9.33 IL4 DEFA1B DEFA1
17 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL4 IL13
18 immune response GO:0006955 9.23 IL5 IL4 IL13 DEFA1B DEFA1 CD4
19 pore formation in membrane of other organism during symbiotic interaction GO:0044657 8.96 DEFA1B DEFA1

Molecular functions related to Mite Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 IL5 IL4 IL31 IL13
2 lipopeptide binding GO:0071723 9.32 CD1B CD1A
3 exogenous lipid antigen binding GO:0030884 9.16 CD1B CD1A
4 endogenous lipid antigen binding GO:0030883 8.96 CD1B CD1A
5 cytokine receptor binding GO:0005126 8.8 IL4 IL31 IL13

Sources for Mite Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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