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MCID: MTR012
MIFTS: 58

Mitral Valve Disease

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mitral Valve Disease

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MalaCards integrated aliases for Mitral Valve Disease:

Name: Mitral Valve Disease 12 55 15
Abnormality of the Mitral Valve 29 6
Chronic Rheumatic Mitral Valve 12 73
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Rheumatic Mitral Insufficiency 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 73
Diseases of Mitral Valve 73
Disease of Mitral Valve 12
Mitral Rh Valve Dis. 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Mitral Valve Disease

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MalaCards based summary : Mitral Valve Disease, also known as abnormality of the mitral valve, is related to orthostatic intolerance and atrial fibrillation. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are TGF-Beta Pathway and Integrin Pathway. The drugs Metoprolol and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 32.4 AGTR1 FBN1 NOS3
2 atrial fibrillation 31.5 ACE AGT AGTR1 NPPA
3 congestive heart failure 30.8 ACE AGTR1 NPPA
4 aortic aneurysm, familial thoracic 1 30.4 FBN1 MMP1 TGFB2
5 end stage renal failure 30.3 ACE AGT AGTR1
6 hyperlucent lung 30.1 IL10 IL4
7 rheumatic heart disease 29.9 ACE IL10 IL4
8 pulmonary hypertension 29.9 ACE NOS3 NPPA SLC6A4 TPH1
9 pulmonary edema 29.7 ACE IL10 NOS3
10 arteries, anomalies of 29.7 ACE AGT AGTR1 AKT1 NOS3
11 coronary artery anomaly 29.6 ACE AGT AGTR1 NOS3 NPPA
12 aortic aneurysm 29.5 FBN1 MMP13 TGFB2
13 stroke, ischemic 29.3 ACE AGTR1 AKT1 FBN1 NOS3
14 aortic coarctation 29.2 ACE AGT AGTR1 FBN1 NOS3
15 hypertension, essential 29.2 ACE AGT AGTR1 NOS3 NPPA
16 heart disease 28.4 ACE AGTR1 CRELD1 FBN1 NOS3 NPPA
17 diabetes mellitus, noninsulin-dependent 27.7 ACE AGER AGT AGTR1 AKT1 NOS3
18 diabetes mellitus 27.6 ACE AGER AGT AGTR1 AKT1 NOS3
19 dilated cardiomyopathy 27.4 ACE AGT AGTR1 IL10 IL4 MMP1
20 cardiac valvular dysplasia, x-linked 11.4
21 mitral valve stenosis 11.4
22 loeys-dietz syndrome 5 11.2
23 pediatric hypertension 10.8 ACE AGT
24 hypoaldosteronism 10.7 ACE NPPA
25 loeys-dietz syndrome 4 10.7 TGFB2 TGFB3
26 chronic actinic dermatitis 10.7 FBN1 MMP1
27 loeys-dietz syndrome 10.6 FBN1 TGFB2 TGFB3
28 posterior urethral valves 10.6 ACE AGT AGTR1
29 anuria 10.6 ACE AGT AGTR1
30 fibromuscular dysplasia 10.6 ACE AGT AGTR1
31 renal tubular dysgenesis 10.6 ACE AGT AGTR1
32 oligohydramnios 10.6 ACE AGT AGTR1
33 tuberculoid leprosy 10.5 IL10 TGFB2 TGFB3
34 renal dysplasia 10.5 ACE AGT AGTR1
35 adrenal gland pheochromocytoma 10.5 AKT1 NOS3
36 tropical endomyocardial fibrosis 10.5 IL10 IL4
37 otosclerosis 10.5 ACE AGT AGTR1
38 inguinal hernia 10.4 FBN1 MMP1 MMP13
39 malignant hypertension 10.4 ACE AGT AGTR1 NPPA
40 aortic aneurysm, familial abdominal, 1 10.3 FBN1 MMP1 MMP13
41 vasculogenic impotence 10.3 ACE NOS3 NPPA
42 chronic kidney failure 10.3 ACE AGT AGTR1 NPPA
43 aortic valve disease 2 10.3 ACE AGT FBN1 NPPA
44 acute mountain sickness 10.3 ACE AGTR1 NOS3
45 hypertensive heart disease 10.3 ACE AGT AGTR1 MMP1
46 nonarteritic anterior ischemic optic neuropathy 10.3 ACE AGTR1 NOS3
47 irritable bowel syndrome 10.3 IL10 SLC6A4 TPH1
48 tungiasis 10.2 IL10 IL4
49 extrinsic cardiomyopathy 10.2 ACE IL10 IL4
50 milk allergy 10.2 IL10 IL4 TGFB2

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 86)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Angina Pectoris
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Constrictive Pericarditis Coronary Artery Aneurysm
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Dressler's Syndrome Dyskinesia of Esophagus
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertrophic Cardiomyopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypothyroidism
Idiopathic Interstitial Pneumonia Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease
Sources

Symptoms & Phenotypes for Mitral Valve Disease

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MGI Mouse Phenotypes related to Mitral Valve Disease:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.52 AGTR1 ACE AGER ADAM17 AGT FBN1
2 homeostasis/metabolism MP:0005376 10.46 AGTR1 ACE AGER ADAM17 AGT FBN1
3 growth/size/body region MP:0005378 10.44 AGT AGTR1 ACE AGER ADAM17 AKT1
4 cellular MP:0005384 10.4 ADAM17 AGER CXCR4 AKT1 CRELD1 IL10
5 behavior/neurological MP:0005386 10.34 AGT ACE AGER AKT1 AGTR1 IL10
6 hematopoietic system MP:0005397 10.34 ADAM17 ACE AGER CXCR4 AKT1 AGTR1
7 immune system MP:0005387 10.34 ADAM17 AGT AGTR1 ACE AGER AKT1
8 mortality/aging MP:0010768 10.28 AGT ADAM17 ACE CXCR4 AKT1 CRELD1
9 endocrine/exocrine gland MP:0005379 10.25 ADAM17 ACE CXCR4 AKT1 IL4 IL10
10 adipose tissue MP:0005375 10.21 AGT ACE CXCR4 AKT1 AGTR1 FBN1
11 integument MP:0010771 10.18 ADAM17 AGER CXCR4 AKT1 IL10 FBN1
12 muscle MP:0005369 10.18 AGER ADAM17 AGT AKT1 FBN1 CXCR4
13 nervous system MP:0003631 10.18 AGT ADAM17 CXCR4 AKT1 CRELD1 AGTR1
14 embryo MP:0005380 10.16 ADAM17 CXCR4 AKT1 CRELD1 IL10 FBN1
15 craniofacial MP:0005382 10.12 CXCR4 CRELD1 IL4 IL10 FBN1 TGFB2
16 digestive/alimentary MP:0005381 10.11 ADAM17 CXCR4 IL4 IL10 NOS3 TGFB2
17 limbs/digits/tail MP:0005371 10 ADAM17 IL10 FBN1 NOS3 TGFB2 MMP13
18 renal/urinary system MP:0005367 9.96 AGT ACE AGER CXCR4 FBN1 AGTR1
19 normal MP:0002873 9.92 ADAM17 AGER AKT1 IL4 IL10 NOS3
20 reproductive system MP:0005389 9.85 AGT ADAM17 ACE CXCR4 AKT1 IL4
21 respiratory system MP:0005388 9.65 ADAM17 CXCR4 AKT1 IL10 FBN1 IL4
22 skeleton MP:0005390 9.4 ADAM17 AGER AKT1 FBN1 CXCR4 IL10
Sources

Drugs & Therapeutics for Mitral Valve Disease

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Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Racepinephrine Approved Phase 4 329-65-7 838
9 Analgesics Phase 4,Phase 2
10 Central Nervous System Depressants Phase 4,Phase 2
11 Analgesics, Non-Narcotic Phase 4,Phase 2
12 Anesthetics Phase 4,Phase 2
13 Anesthetics, Local Phase 4,Phase 2
14 Anti-Arrhythmia Agents Phase 4,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Pharmaceutical Solutions Phase 4,Not Applicable
17 Adrenergic Agents Phase 4
18 Adrenergic Antagonists Phase 4
19 Adrenergic beta-1 Receptor Antagonists Phase 4
20 Adrenergic beta-Antagonists Phase 4,Not Applicable
21 Sympatholytics Phase 4
22 Neurotransmitter Agents Phase 4
23 Antihypertensive Agents Phase 4
24 Autonomic Agents Phase 4
25 Narcotics Phase 4
26 Analgesics, Opioid Phase 4
27 Anesthetics, General Phase 4
28 Antipyretics Phase 4
29 Epinephryl borate Phase 4
30 Carticaine Phase 4
31
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
32 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
33 Vasodilator Agents Phase 2, Phase 3
34 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
35 Phosphodiesterase Inhibitors Phase 2, Phase 3
36 Citrate Nutraceutical Phase 2, Phase 3
37
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
38
Ketorolac Approved Phase 2 74103-06-3, 66635-83-4 3826
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
40 Sodium Channel Blockers Phase 2
41 Cyclooxygenase Inhibitors Phase 2
42 Diuretics, Potassium Sparing Phase 2
43 Ketorolac Tromethamine Phase 2
44 Anti-Inflammatory Agents Phase 2
45 Anti-Inflammatory Agents, Non-Steroidal Phase 2
46 Antirheumatic Agents Phase 2
47
Dopamine Approved 51-61-6, 62-31-7 681
48
Cabergoline Approved 81409-90-7 54746
49
Levodopa Approved 59-92-7 6047
50 Plasma-lyte 148 Not Applicable

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
2 General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function Recruiting NCT03013075 Phase 4 Bupivacaine heavy and Morphine;General Anesthetics
3 Postoperative Analgesia After Minithoracotomy Recruiting NCT03415555 Phase 4 Oxycodone;paracetamol
4 Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Terminated NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
5 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
6 Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
7 Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial) Active, not recruiting NCT02435303 Phase 2, Phase 3 Sildenafil;Placebo
8 Preoperative Oral Immunonutrition and Cardiac Patients Active, not recruiting NCT03445221 Phase 2, Phase 3
9 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
10 Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery Completed NCT01481350 Phase 2 sildenafil
11 Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation Completed NCT00807040 Phase 2
12 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
13 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery Unknown status NCT02374229 Phase 1
14 St. Jude Medical Percutaneous Mitral Valve Repair Study Completed NCT01500148 Phase 1
15 Mitral Implantation of TRAnscatheter vaLves Active, not recruiting NCT02370511 Phase 1
16 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524 Not Applicable
17 Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring Unknown status NCT01987635 Not Applicable
18 Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5% Unknown status NCT01849757 Not Applicable
19 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Unknown status NCT02804321
20 Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry Unknown status NCT02039622
21 Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease Completed NCT03278574 Not Applicable
22 Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery Completed NCT01646541
23 The Effectiveness of Respiratory Physiotherapy in Mitral Valve Surgery Completed NCT02278835 Not Applicable
24 Safety and Performance Study of the NeoChord Device Completed NCT01777815 Not Applicable
25 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Completed NCT01246947 Not Applicable
26 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262 Not Applicable
27 Identifying an Ideal Cardiopulmonary Exercise Test Parameter Completed NCT01162083
28 Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR Completed NCT02371863
29 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
30 Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery Recruiting NCT02925819
31 A Modified Cox-Maze Operation for the Treatment of Permanent Atrial Fibrillation With Mitral Valve Disease Recruiting NCT03347695 Not Applicable
32 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study Recruiting NCT03155373
33 PRESERVE-MITRAL Post-Market Registry Recruiting NCT03283722
34 Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach Recruiting NCT03195595
35 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552 Not Applicable
36 Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders Recruiting NCT03365453 Not Applicable
37 Early Initiation of Post Sternotomy CArdiac Rehabilitation Recruiting NCT03223558 Not Applicable
38 Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair Recruiting NCT02803957 Not Applicable
39 STS/ACC TVT Registry Mitral Module Recruiting NCT02245763
40 MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery Recruiting NCT03012178
41 PARTNER 3 Trial - Mitral Valve in Valve Recruiting NCT03193801 Not Applicable
42 PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients Recruiting NCT03438825
43 Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
44 Improving Mitral Repair for Functional Mitral Regurgitation Recruiting NCT03366649 Not Applicable
45 Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation Recruiting NCT03433274 Not Applicable
46 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
47 HALO: A Single Arm Prospective Investigation of the SJMâ„¢ Masters HPâ„¢ 15mm Rotatable Mechanical Heart Valve Active, not recruiting NCT02097420 Not Applicable
48 Long Term Follow Up for CTSN Mitral Valve Repair Studies Enrolling by invitation NCT03066050
49 Mitral Annuloplasty Rings RCT Not yet recruiting NCT03290872 Not Applicable
50 Right Ventricular Echo Assessment in Mitral Valve Replacement Not yet recruiting NCT03549052

Search NIH Clinical Center for Mitral Valve Disease

Sources

Genetic Tests for Mitral Valve Disease

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Genetic tests related to Mitral Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 29
Sources

Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

41
Heart, Testes, Endothelial, Whole Blood, Lung, Brain, Smooth Muscle
Sources

Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50) (show all 673)
# Title Authors Year
1
Pulmonary Hypertension in Aortic and Mitral Valve Disease. ( 29876357 )
2018
2
Causes of repair failure for degenerative mitral valve disease and reoperation outcomes. ( 29309559 )
2018
3
Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. ( 29390969 )
2018
4
Polymorphism, coupling interval and prematurity index in dogs with degenerative mitral valve disease and ventricular arrhythmias. ( 29536334 )
2018
5
Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease. ( 29200408 )
2018
6
[Corrigendum] Differences in atrial fibrillationa89associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis. ( 29956758 )
2018
7
Simple versus complex degenerative mitral valve disease. ( 29709354 )
2018
8
Regional Left Ventricular Myocardial Mechanics in Degenerative Myxomatous Mitral Valve Disease: A Comparison Between Fibroelastic Deficiency and Barlow's Disease. ( 29361488 )
2018
9
Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease. ( 29315310 )
2018
10
Repair for rheumatic mitral valve disease. The controversy goes on! ( 29331985 )
2018
11
Application of left ventricular strain in patients with aortic and mitral valve disease. ( 29889664 )
2018
12
Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration. ( 29428085 )
2018
13
Long-term results of suture annuloplasty for degenerative mitral valve disease: a propensity-matched analysis. ( 29206693 )
2018
14
Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. ( 29214723 )
2018
15
Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease. ( 29572938 )
2018
16
Echocardiographic Estimates of Right Ventricular Systolic Function in Dogs with Myxomatous Mitral Valve Disease. ( 29224256 )
2018
17
Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease: Results From the Registry of Pregnancy and Cardiac Disease. ( 29459466 )
2018
18
Left atrial deformation and phasic function determined by two-dimensional speckle-tracking echocardiography in dogs with myxomatous mitral valve disease. ( 29459124 )
2018
19
Future Technology of Mitral Valve Repair and Replacement for Mitral Valve Disease. ( 29897014 )
2018
20
Effects of the angiotensin-converting enzyme inhibitor alacepril in dogs with mitral valve disease. ( 29937457 )
2018
21
Bileaflet pericardial patch repair for rheumatic mitral valve disease. ( 29943524 )
2018
22
Giant coronary sinus secondary to partial anomalous pulmonary venous connection with combined mitral valve disease. ( 29593822 )
2018
23
Prosthesis selection for repair of degenerative mitral valve disease. ( 29866534 )
2018
24
Risk Factors of Recurrence of Atrial Fibrillation after AF Surgery in Patients with AF and Mitral Valve Disease. ( 29410135 )
2018
25
Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease. ( 29420783 )
2018
26
Correlation between serum homocysteine concentration and severity of mitral valve disease in dogs. ( 28345991 )
2017
27
Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging. ( 28540065 )
2017
28
Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease. ( 28453968 )
2017
29
A retrospective study of degenerative mitral valve disease in small-breed dogs: Survival and prognostic variables. ( 28057898 )
2017
30
Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease. ( 28705792 )
2017
31
Concomitant or Staged Transcatheter Treatment for Severe Combined Aortic and Mitral Valve Disease. ( 28579347 )
2017
32
Mitral valve morphology assessed by three-dimensional transthoracic echocardiography in healthy dogs and dogs with myxomatous mitral valve disease. ( 28279678 )
2017
33
Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs. ( 28145607 )
2017
34
Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration. ( 28132441 )
2017
35
Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease. ( 28380134 )
2017
36
Association Between Myxomatous Mitral Valve Disease and Skeletal Back Abnormalities. ( 29762925 )
2017
37
Aldosterone breakthrough in dogs with naturally occurring myxomatous mitral valve disease. ( 28576479 )
2017
38
The Cox-Maze IV procedure for atrial fibrillation is equally efficacious in patients with rheumatic and degenerative mitral valve disease. ( 28583297 )
2017
39
Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays. ( 28449360 )
2017
40
Polymorphisms in the serotonin transporter protein gene in Maltese dogs with degenerative mitral valve disease. ( 28693307 )
2017
41
Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model. ( 28804599 )
2017
42
Use of a Minimally Invasive Cardiac Output Monitor to Optimise Haemodynamics in a Patient with Mitral Valve Disease Undergoing Cerebrovascular Surgery. ( 29062560 )
2017
43
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
44
Exercise Testing and Stress Imaging in Mitral Valve Disease. ( 28290006 )
2017
45
Complex robotic correction for complex degenerative mitral valve disease. ( 28203546 )
2017
46
Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study. ( 28734620 )
2017
47
Review of Diagnostic and Therapeutic Approach to Canine Myxomatous Mitral Valve Disease. ( 29056705 )
2017
48
Outcome reporting for surgical treatment of degenerative mitral valve disease: a systematic review and critical appraisal. ( 29236990 )
2017
49
Serum proteomic profiles in CKCS with Mitral valve disease. ( 28173805 )
2017
50
Substrate characteristics and ablation outcome of left atrial tachycardia in rheumatic mitral valve disease. ( 28594430 )
2017
Sources

Variations for Mitral Valve Disease

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ClinVar genetic disease variations for Mitral Valve Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ESRRG; GPATCH2; RRP15; SPATA17; TGFB2; USH2A GRCh37/hg19 1q41(chr1: 215829463-219225857) copy number loss Pathogenic GRCh37 Chromosome 1, 215829463: 219225857
Sources

Expression for Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.
Sources

Pathways for Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.36 AGT AGTR1 AKT1 CXCR4 IL10 IL4
2
Integrin Pathway 64
Show member pathways
 13.33 AKT1 CXCR4 FBN1 MMP1 MMP13 TGFB2
3
Akt Signaling 64
Show member pathways
 13.32 AKT1 CXCR4 IL10 IL4 NOS3 TGFB2
4
p70S6K Signaling 64
Show member pathways
 12.86 ACE AGT AGTR1 AKT1 IL4 TGFB2
5
Degradation of the extracellular matrix 66
Show member pathways
 12.54 ADAM17 FBN1 MMP1 MMP13 TGFB2 TGFB3
6
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.38 AKT1 NPPA TGFB2 TGFB3
7
Th17 cell differentiation 37
Show member pathways
 12.35 IL10 IL4 TGFB2 TGFB3
8
IL-17 Family Signaling Pathways 65
Show member pathways
 12.24 AKT1 IL4 MMP1 MMP13
9
Pathways in cancer 37
12.22 AGTR1 AKT1 CXCR4 IL4 MMP1 TGFB2
10
Tuberculosis 37
12.12 AKT1 IL10 TGFB2 TGFB3
11
Colorectal Cancer Metastasis 64
12.05 AKT1 MMP1 TGFB2 TGFB3
12
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.97 AKT1 IL10 IL4 TGFB2 TGFB3
13
FoxO signaling pathway 37
Show member pathways
 11.94 AKT1 IL10 TGFB2 TGFB3
14
Toxoplasmosis 37
Show member pathways
 11.93 AKT1 IL10 IL4 TGFB2 TGFB3
15
HIF-1 signaling pathway 37
11.83 AKT1 NOS3 NPPA
16
Matrix Metalloproteinases 1
Show member pathways
 11.83 ADAM17 MMP1 MMP13
17
Interleukin-4 and 13 signaling 66
11.81 AKT1 IL10 IL4 MMP1
18
Amoebiasis 37
11.8 IL10 TGFB2 TGFB3
19
TGF-beta Signaling Pathways 65
11.8 AKT1 TGFB2 TGFB3
20
Rheumatoid arthritis 37
11.76 MMP1 TGFB2 TGFB3
21
Jak-Stat Signaling Pathway 67
11.76 AGTR1 AKT1 CXCR4 IL10
22
Glucocorticoid receptor regulatory network 1
11.71 AKT1 IL4 MMP1
23
Elastic fibre formation 66
Show member pathways
 11.65 FBN1 TGFB2 TGFB3
24
Angiogenesis (CST) 4
11.62 MMP13 NOS3 TGFB2 TGFB3
25
Endochondral Ossification 1
11.59 AKT1 MMP13 TGFB2
26
Renin secretion 37
11.58 ACE AGT AGTR1
27
IL4-mediated signaling events 1
11.56 AKT1 IL10 IL4
28
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.53 ACE AGT AGTR1 NOS3
29
A-beta Signaling Pathways 65
11.49 ADAM17 AGER AKT1
30
Malaria 37
11.41 IL10 TGFB2 TGFB3
31
AGE/RAGE pathway 1
11.28 AGER AKT1 MMP13 NOS3
32
Extracellular vesicle-mediated signaling in recipient cells 1
11.13 AKT1 TGFB2 TGFB3
33
AGE-RAGE signaling pathway in diabetic complications 37
11.1 AGER AGTR1 AKT1 NOS3 TGFB2 TGFB3
Sources

GO Terms for Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ACE AGT FBN1 IL10 IL4 MMP13
2 extracellular region GO:0005576 9.7 ACE AGER AGT FBN1 IL10 IL4
3 extracellular matrix GO:0031012 9.1 FBN1 MMP1 MMP13 NPPA TGFB2 TGFB3

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.97 AGT AGTR1 TGFB2 TGFB3
2 cellular protein metabolic process GO:0044267 9.92 FBN1 MMP1 MMP13 NPPA
3 aging GO:0007568 9.89 AGT AKT1 IL10 TGFB3
4 response to organic substance GO:0010033 9.87 AKT1 IL10 SLC6A4
5 female pregnancy GO:0007565 9.86 AGT NPPA TGFB3
6 extracellular matrix disassembly GO:0022617 9.84 FBN1 MMP1 MMP13
7 positive regulation of cell growth GO:0030307 9.83 ADAM17 AKT1 TGFB2
8 cellular response to mechanical stimulus GO:0071260 9.83 AGT AKT1 NPPA
9 B cell differentiation GO:0030183 9.81 ADAM17 IL10 IL4
10 regulation of signaling receptor activity GO:0010469 9.8 AGT FBN1 IL10 IL4 NPPA TGFB2
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.75 ADAM17 AKT1 NOS3
12 positive regulation of cell cycle GO:0045787 9.71 IL10 SLC6A4 TGFB2
13 cell adhesion mediated by integrin GO:0033627 9.7 ADAM17 FBN1
14 cell growth involved in cardiac muscle cell development GO:0061049 9.7 AGT NPPA
15 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 AGT AGTR1
16 regulation of blood vessel diameter GO:0097746 9.69 ACE AGTR1
17 nitric oxide biosynthetic process GO:0006809 9.68 AKT1 NOS3
18 low-density lipoprotein particle remodeling GO:0034374 9.68 AGT AGTR1
19 secondary palate development GO:0062009 9.68 TGFB2 TGFB3
20 angiotensin maturation GO:0002003 9.67 ACE AGT
21 blood vessel remodeling GO:0001974 9.67 ACE AGT NOS3
22 cofactor metabolic process GO:0051186 9.65 AKT1 NOS3
23 neutrophil mediated immunity GO:0002446 9.65 ACE ADAM17
24 salivary gland morphogenesis GO:0007435 9.64 TGFB2 TGFB3
25 positive regulation of cholesterol esterification GO:0010873 9.63 AGT AGTR1
26 response to fluid shear stress GO:0034405 9.63 AKT1 NOS3
27 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 IL4
28 regulation of blood pressure GO:0008217 9.62 ACE AGT NOS3 NPPA
29 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.61 ADAM17 AKT1
30 positive regulation of NAD(P)H oxidase activity GO:0033864 9.61 AGT AGTR1
31 regulation of vasoconstriction GO:0019229 9.61 ACE AGT AGTR1
32 type 2 immune response GO:0042092 9.6 IL10 IL4
33 negative regulation of macrophage cytokine production GO:0010936 9.58 TGFB2 TGFB3
34 regulation of blood vessel size GO:0050880 9.58 AGT NOS3 NPPA
35 regulation of isotype switching GO:0045191 9.57 IL10 IL4
36 regulation of renal sodium excretion GO:0035813 9.56 AGT AGTR1
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.55 AGT AGTR1
38 kidney development GO:0001822 9.55 ACE AGT AGTR1 FBN1 TGFB2
39 positive regulation of cellular protein metabolic process GO:0032270 9.54 AGT AGTR1 AKT1
40 regulation of complement-dependent cytotoxicity GO:1903659 9.52 IL10 TGFB2
41 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.51 AGT AGTR1
42 regulation of renal output by angiotensin GO:0002019 9.48 ACE AGT
43 uterine wall breakdown GO:0042704 9.46 TGFB2 TGFB3
44 response to hypoxia GO:0001666 9.17 ADAM17 AGER CXCR4 NPPA SLC6A4 TGFB2
45 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
46 positive regulation of cell proliferation GO:0008284 10.07 ADAM17 AGT AKT1 TGFB2 TGFB3

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 IL10 IL4 TGFB2 TGFB3
2 metallopeptidase activity GO:0008237 9.56 ACE ADAM17 MMP1 MMP13
3 BMP receptor binding GO:0070700 9.4 TGFB2 TGFB3
4 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFB3
5 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB2 TGFB3
6 growth factor activity GO:0008083 9.02 AGT IL10 IL4 TGFB2 TGFB3
7 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
Sources

Sources for Mitral Valve Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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