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MCID: MTR012
MIFTS: 57

Mitral Valve Disease

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mitral Valve Disease

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MalaCards integrated aliases for Mitral Valve Disease:

Name: Mitral Valve Disease 12 54 15 17
Abnormality of the Mitral Valve 29 6
Chronic Rheumatic Mitral Valve 12 70
Rheumatic Mitral Insufficiency 12 32
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 70
Diseases of Mitral Valve 70
Disease of Mitral Valve 12
Mitral Rh Valve Dis. 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:61
ICD9CM 34 394 394.1 424.0
NCIt 50 C78446
UMLS 70 C0026265 C0155563 C0264765 more
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Summaries for Mitral Valve Disease

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MalaCards based summary : Mitral Valve Disease, also known as abnormality of the mitral valve, is related to loeys-dietz syndrome 5 and mitral valve stenosis. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are TGF-Beta Pathway and Integrin Pathway. The drugs Warfarin and Enoxaparin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 loeys-dietz syndrome 5 32.6 TGFB3 TGFB2 FBN1
2 mitral valve stenosis 32.6 NPPB NPPA ACE
3 orthostatic intolerance 32.1 TGFB2 NOS3 MIR423 FBN1 AGTR1 ACE
4 mitral valve insufficiency 31.9 NPPB NPPA MIR423 FBN1 ACE
5 tricuspid valve insufficiency 31.6 NPPB FBN1 ACE
6 atrial fibrillation 31.4 NPPB NPPA AGTR1 AGT ACE
7 rheumatic heart disease 31.2 NPPB IL4 IL10 ACE
8 heart valve disease 31.2 NPPB NPPA MIR423 FBN1 ACE
9 congestive heart failure 31.2 NPPB NPPA NOS3 AGTR1 AGT ACE
10 aortic valve insufficiency 31.2 NPPB NPPA FBN1 ACE
11 pulmonary hypertension 31.1 TPH1 SLC6A4 NPPB NPPA NOS3 AGTR1
12 atrial heart septal defect 31.1 NPPB NPPA FBN1 ACE
13 tricuspid valve disease 31.1 NPPB FBN1 ACE
14 rheumatic fever 31.1 NPPB IL10 ACE
15 aortic valve disease 1 31.0 TGFB3 TGFB2 NOS3 FBN1 AGTR1 ACE
16 sick sinus syndrome 30.9 NPPA MIR423 AGT
17 arteries, anomalies of 30.8 NOS3 MIR423 AGTR1 ACE
18 marfan syndrome 30.8 TGFB2 MMP1 FBN1 AGTR1
19 pulmonary edema 30.7 NPPB NPPA NOS3 IL10 AGTR1 ACE
20 aneurysm 30.7 TGFB3 TGFB2 MMP13 FBN1
21 patent foramen ovale 30.6 NPPB NPPA FBN1 ACE
22 aortic dissection 30.6 TGFB3 TGFB2 FBN1 ACE
23 eclampsia 30.5 NOS3 AGT ACE
24 tricuspid valve prolapse 30.5 TGFB3 TGFB2 FBN1
25 coronary stenosis 30.5 NPPB CXCR4 ACE
26 arteriosclerosis 30.4 NOS3 IL4 IL10 FBN1 ACE
27 loeys-dietz syndrome 30.4 TGFB3 TGFB2 FBN1 AGTR1
28 angina pectoris 30.4 NPPB NOS3 ACE
29 pericardial effusion 30.4 NPPB NPPA ACE
30 aortic aneurysm, familial thoracic 1 30.3 TGFB3 TGFB2 MMP1 FBN1 AGTR1
31 aortic aneurysm 30.3 TGFB3 TGFB2 MMP13 FBN1 ACE
32 patent ductus arteriosus 1 30.3 NPPB FBN1 ACE
33 intracranial aneurysm 30.2 TGFB2 NOS3 ACE
34 aortic disease 30.2 TGFB3 TGFB2 MIR423 FBN1 ACE
35 myocarditis 30.2 NPPB IL4 IL10 ACE
36 migraine with or without aura 1 30.2 TPH1 SLC6A4 NOS3 IL10 ACE
37 familial hypercholesterolemia 30.2 NPPA NOS3 IL10 AGTR1 AGT ACE
38 ischemia 30.1 NPPB NOS3 AKT1 ACE
39 acute myocardial infarction 30.1 NPPB NPPA MIR423 AGTR1 ACE
40 dilated cardiomyopathy 30.0 TGFB3 TGFB2 NPPB NPPA NOS3 MMP1
41 chronic kidney disease 30.0 NPPB NPPA NOS3 IL10 AGTR1 AGT
42 aortic valve disease 2 30.0 NPPB NPPA MIR423 FBN1 AGT ACE
43 hypertrophic cardiomyopathy 30.0 TGFB3 TGFB2 NPPB NPPA NOS3 MMP1
44 kidney disease 29.9 NPPB NPPA NOS3 AGTR1 AGT AGER
45 vascular disease 29.9 SLC6A4 NPPB NOS3 IL10 AGT AGER
46 lipoprotein quantitative trait locus 29.8 TGFB2 NPPB NPPA NOS3 MIR423 IL4
47 pre-eclampsia 29.8 TGFB3 NPPA NOS3 IL4 IL10 AGTR1
48 stroke, ischemic 29.7 NPPB NPPA NOS3 FBN1 CXCR4 AKT1
49 heart disease 29.5 TGFB3 SLC6A4 NPPB NPPA NOS3 MMP1
50 type 2 diabetes mellitus 29.5 NPPB NOS3 MMP1 IL4 IL10 AKT1

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 84)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Angina Pectoris
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Disease
Chronic Pulmonary Heart Disease Constrictive Pericarditis
Coronary Artery Aneurysm Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Disseminated Intravascular Coagulation Dressler's Syndrome
Dyskinesia of Esophagus Dysthymic Disorder
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hepatitis
Hyperlipoproteinemia, Type Iv Hyperlipoproteinemia, Type V
Hypertension, Essential Hypertrophic Cardiomyopathy
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypothyroidism Idiopathic Interstitial Pneumonia
Intermediate Coronary Syndrome Intracranial Embolism

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease
Sources

Symptoms & Phenotypes for Mitral Valve Disease

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MGI Mouse Phenotypes related to Mitral Valve Disease:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 ACE AGER AGT AGTR1 AKT1 CXCR4
2 homeostasis/metabolism MP:0005376 10.43 ACE AGER AGT AGTR1 AKT1 CXCR4
3 growth/size/body region MP:0005378 10.41 ACE AGER AGT AGTR1 AKT1 CXCR4
4 cellular MP:0005384 10.36 AGER AKT1 CXCR4 FBN1 IL10 IL4
5 hematopoietic system MP:0005397 10.31 ACE AGER AGTR1 AKT1 CXCR4 FBN1
6 immune system MP:0005387 10.3 ACE AGER AGT AGTR1 AKT1 CXCR4
7 endocrine/exocrine gland MP:0005379 10.26 ACE AKT1 CXCR4 FBN1 IL10 IL4
8 adipose tissue MP:0005375 10.17 ACE AGT AGTR1 AKT1 CXCR4 FBN1
9 muscle MP:0005369 10.15 AGER AGT AKT1 CXCR4 FBN1 IL10
10 digestive/alimentary MP:0005381 10.14 CXCR4 IL10 IL4 NOS3 PTK2 SLC6A4
11 integument MP:0010771 10.13 AGER AKT1 CXCR4 FBN1 IL10 IL4
12 nervous system MP:0003631 10.13 ACE AGT AGTR1 AKT1 CXCR4 FBN1
13 renal/urinary system MP:0005367 9.96 ACE AGER AGT AGTR1 CXCR4 FBN1
14 limbs/digits/tail MP:0005371 9.95 FBN1 IL10 MMP13 NOS3 PTK2 TGFB2
15 reproductive system MP:0005389 9.85 ACE AGT AKT1 CXCR4 FBN1 IL10
16 respiratory system MP:0005388 9.65 AKT1 CXCR4 FBN1 IL10 IL4 NOS3
17 skeleton MP:0005390 9.36 AGER AKT1 CXCR4 FBN1 IL10 IL4
Sources

Drugs & Therapeutics for Mitral Valve Disease

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Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 54678486 6691
2
Enoxaparin Approved Phase 4 9005-49-6 772
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7 Anticoagulants Phase 4
8 Fibrinolytic Agents Phase 4
9 Pharmaceutical Solutions Phase 4
10 Epinephryl borate Phase 4
11 Anesthetics Phase 4
12 Carticaine Phase 4
13 Anesthetics, Local Phase 4
14
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
15
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
16 Vasodilator Agents Phase 2, Phase 3
17 Citrate Phase 2, Phase 3
18 Phosphodiesterase Inhibitors Phase 2, Phase 3
19 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
20 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
21
Bosentan Approved, Investigational 147536-97-8 104865
22 Antihypertensive Agents
23 Endothelin Receptor Antagonists

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Evaluation of Warfarin Initiation at 3mg Versus 5mg for Anticoagulation of Mechanical Mitral Valve Replacement Patients Completed NCT04235569 Phase 4 Warfarin Sodium 5 MG;Warfarin Sodium 3 MG;Enoxaparin Sodium 100 MG/ML Prefilled Syringe
2 Comparison of Periosteal and Subcutaneous Infusions of Articaine and Bupivacaine in Treatment of Acute Pain After Sternotomy Suspended NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
3 Clinical Investigation Of The Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
4 The Safety and Effectiveness of the SAPIEN 3 and SAPIEN 3 Ultra Valve in Patients With Symptomatic Severe Calcific Mitral Valve Disease With Severe Mitral Annular Calcification Who Are Not Candidates for Standard Mitral Valve Surgery. Recruiting NCT04408430 Phase 2, Phase 3
5 Effect of Sildenafil for the Treatment of Sustained Pulmonary Artery Hypertension After Corrected Mitral Valve Disease Terminated NCT02435303 Phase 2, Phase 3 Sildenafil;Placebo
6 Surgical Ablation of Ganglion Plexuses of the Pulmonary Artery in Patients With Valvular Heart Disease, Complicated by High Pulmonary Hypertension May Reduce Its Degree. Unknown status NCT02374229 Phase 1
7 Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac Surgery Unknown status NCT01184404 Bosentan
8 A Study to Assess the Effects of Two Commonly Used Mitral Valve Annuloplasty Rings in Mitral Valve Repair on Short-term Outcomes. Unknown status NCT03290872
9 Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring Unknown status NCT01987635
10 Comparison Between Outcomes Of Ring And Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
11 To Analyze the Effectiveness of Respiratory Physiotherapy Techniques in the Post Operative Mitral Valve Completed NCT02278835
12 Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Mitral Valve Surgery Completed NCT03697941
13 Assessment of the Effect of Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation in Patients Undergoing Open Heart Surgery Completed NCT03239262
14 Safety and Performance Study of the NeoChord Suturing Device in Subjects With Degenerative Mitral Valve Disease; Diagnosed With Severe Mitral Regurgitation Completed NCT01777815
15 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Completed NCT03155373
16 Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease Completed NCT04078867
17 Mitral Valve Repair Using Flexible Bands Versus Complete Rings in Patients With Degenerative Mitral Valve Disease: a Prospective, Randomized Study Completed NCT03278574
18 Registry for Mitral Valve Surgery at Department of Cardiac Surgery University Hospital of Basel/ Switzerland Recruiting NCT03587688
19 Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement Investigational Device Exemption Recruiting NCT04717570
20 Autonomous Robotics for Transcatheter dEliveRy sYstems Recruiting NCT04787757
21 Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System Compared to Abbott MitraClip in Patients With Mitral Regurgitation Recruiting NCT03706833
22 Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach Recruiting NCT03195595
23 Intraoperative Transesophageal Echocardiography in On-pump Mitral Surgery: A Single Center Prospective Observational Study of Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome Recruiting NCT04045340
24 Management And Clinical Outcomes Of Patients With Severe Mitral Disease Not Suitable For Surgery: A Prospective, Multicentric, Observational Study Recruiting NCT02925819
25 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552
26 Evaluation of the Efficacy and Safety of the Mi-thos® Transcatheter Mitral Valve Replacement System in Patients With Severe Mitral Valve Disease at High Surgical Risk. Recruiting NCT04195984
27 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
28 Prospective REgistry to Study Clinical OutcomEs of Repair of Mitral ValvEs in South Asia Active, not recruiting NCT03283722
29 The Safety and Feasibility of the SAPIEN XTTM Transcatheter Heart Valve With NovaFlex and Ascendra Delivery Systems and SAPIEN 3 With Commander Delivery System in Patients With Symptomatic Severe Calcific Mitral Valve Disease With Severe Mitral Annular Calcification and Patients With Failing Mitral Surgical Rings or Bioprostheses Who Are Not Candidates for Mitral Valve Surgery. Active, not recruiting NCT02370511
30 Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae Active, not recruiting NCT03674593
31 HALO Clinical Study: A Single Arm, Prospective, Non-randomized, Multi Center Investigation of the SJMâ„¢ Masters HPâ„¢ 15mm Rotatable Mechanical Heart Valve Active, not recruiting NCT02097420
32 International Multicenter Registry of Patients With Concomitant Aortic and Mitral Valve Disease Undergoing Transcatheter Aortic Valve Implantation - The Aortic+Mitral TRAnsCatheter (AMTRAC) Valve Registry Enrolling by invitation NCT04031274
33 Assessment of Subclinical Left Atrial and Left Ventricular Dysfunction by Speckle Tracking Echocardiography in Severe Asymptomatic Rheumatic Mitral Regurgitation and Its Role in Predicting Outcome After Valve Replacement Compared to Guideline Parameters Not yet recruiting NCT03870516
34 A Prospective, Multicenter, Objective Performance Criteria Study to Evaluate the Safety and Effectiveness of Dragonfly Transcatheter Mitral Valve Repair System for the Treatment of Degenerative Mitral Regurgitation (DMR) Subjects. Not yet recruiting NCT04734756
35 Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation (EXPLORE DMR) Not yet recruiting NCT04679662
36 Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Degenerative Mitral Regurgitation (EXPLORE DMR) Not yet recruiting NCT04666480
37 Mitral Valve Screening Survey (MVSS) Not yet recruiting NCT04736667
38 A Randomized, Single-blind Prophylactic Pulmonary Vein Isolation Procedure Utilizing Bipolar Radiofrequency Ablation in Patients Undergoing Mitral Valve Surgery Terminated NCT00587899
39 Evaluation of Outcomes of Cardiac Resynchronization Therapy and MitraClip for the Treatment of Low Ejection Fraction and Functional Mitral Valve Regurgitation in Heart Failure Withdrawn NCT02985268 Optimal Medical Therapy

Search NIH Clinical Center for Mitral Valve Disease

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Genetic Tests for Mitral Valve Disease

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Genetic tests related to Mitral Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 29
Sources

Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

40
Heart, Endothelial, Kidney, Smooth Muscle, Lung, Breast, Cortex
Sources

Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50) (show all 3166)
# Title Authors PMID Year
1
Decreased plasma brain natriuretic peptide levels after a successful maze procedure. 54 61
12803326 2003
2
[The influence of electrical cardioversion on left ventricular systolic function, left atrial size, ANP levels and enzymatic activity of CPK and CD-MB in serum of patients with paroxysmal atrial fibrillation]. 61 54
9501676 1997
3
Plasma ANP and cyclic GMP after physical exercise in patients with mitral valve disease and in healthy subjects. 61 54
8225655 1993
4
[Atrial natriuretic peptide in rheumatic mitral valve disease]. 54 61
8351229 1993
5
Current status of the treatment of degenerative mitral valve regurgitation. 61
33745777 2021
6
Mitral valve repair rates in degenerative mitral valve disease correlate with surgeon and hospital procedural volume. 61
33616240 2021
7
"Learning curve and procedural volume in mitral valve disease". 61
33616264 2021
8
Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease. 61
33764833 2021
9
Impact of concomitant tricuspid annuloplasty on right ventricular remodeling in patients with rheumatic mitral valve disease. 61
33663519 2021
10
Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease. 61
33634912 2021
11
Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease. 61
33645846 2021
12
Red Cell Distribution Width Has a Negative Prognostic Role in Dogs with Myxomatous Mitral Valve Disease. 61
33799710 2021
13
Transcatheter Mitral Valve Replacement: An Update on Current Techniques, Technologies, and Future Directions. 61
33663778 2021
14
Left atrial decompression as a palliative minimally invasive treatment for congestive heart failure caused by myxomatous mitral valve disease in dogs: 17 cases (2018-2019). 61
33683957 2021
15
Defining a Clinically Important Change in 6-Minute Walk Distance in Patients With Heart Failure and Mitral Valve Disease. 61
33663234 2021
16
Review of transapical off-pump mitral valve intervention with NeoChord implantation. 61
33394708 2021
17
Interobserver variability of radiographic methods for the evaluation of left atrial size in dogs. 61
33226167 2021
18
Reduction plasty for giant left atrium causing dysphagia: a case report. 61
32965607 2021
19
Surgical and Transcatheter Mitral Valve Replacement in Mitral Annular Calcification: A Systematic Review. 61
33728929 2021
20
Effect of a dedicated mitral heart team compared to a general heart team on survival: a retrospective, comparative, non-randomized interventional cohort study based on prospectively registered data. 61
33783480 2021
21
Computed Tomography-Derived 3D Modeling to Guide Sizing and Planning of Transcatheter Mitral Valve Interventions. 61
33744155 2021
22
Impact of Economic Status on Utilization and Outcomes of Transcatheter Aortic Valve Implantation and Mitraclip. 61
33285094 2021
23
Sinus rhythm voltage fingerprinting in patients with mitral valve disease using a high-density epicardial mapping approach. 61
33432326 2021
24
Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta-analysis. 61
33372377 2021
25
Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels. 61
33800666 2021
26
How to incorporate left atrial strain in the diagnostic algorithm of left ventricular diastolic dysfunction. 61
33128641 2021
27
Mitral valve repair in children with rheumatic heart disease. 61
33642715 2021
28
An unusual case of spontaneous obstructive thrombus complicating rheumatic mitral stenosis. 61
33767492 2021
29
The Commando procedure: Can it be a preventive option from reoperation in pediatric patients? 61
33428270 2021
30
Mitral Valve Subacute Endocarditis Caused by Abiotrophia Defectiva: A Case Report. 61
33801364 2021
31
Innovative transcatheter procedures for the treatment of heart failure. 61
33708500 2021
32
Predictors of reoccurrence of congestive signs within 180 days after successful treatment of the first episode of congestive heart failure in dogs with myxomatous mitral valve disease. 61
33706221 2021
33
Residual versus recurrent mitral regurgitation after transcatheter mitral valve edge-to-edge repair. 61
33625788 2021
34
Prosthetic choice in mitral valve replacement for severe chronic ischemic mitral regurgitation: Long-term follow-up. 61
33674062 2021
35
Evaluation of Mitral and Aortic Valvular Disease and Left Ventricular Dysfunction in a Lebanese Population: Retrospective Single-Center Experience. 61
33558450 2021
36
Activation of the Interleukin-33/ST2 Pathway Exerts Deleterious Effects in Myxomatous Mitral Valve Disease. 61
33669101 2021
37
The effect of myxomatous mitral valve disease severity on packed cell volume in dogs. 61
33599987 2021
38
T-wave peak-end interval and ratio of T-wave peak-end and QT intervals: novel arrhythmogenic and survival markers for dogs with myxomatous mitral valve disease. 61
33812131 2021
39
P-Wave Terminal Force in Dogs With Myxomatous Mitral Valve Disease. 61
33652154 2021
40
Comparison of N-terminal pro-atrial natriuretic peptide and three cardiac biomarkers for discriminatory ability of clinical stage in dogs with myxomatous mitral valve disease. 61
33551383 2021
41
Temporal outcomes of transcatheter mitral valve replacement in native mitral valve disease with annular calcification. 61
33539045 2021
42
Two-dimensional echocardiographic measures of left ventricular dimensions agree with M-mode measurements in dogs. 61
33444875 2021
43
The impact of pulmonary artery catheter use in cardiac surgery. 61
33642109 2021
44
[Patient owner surveys in small animal medicine - importance, benefits and pitfalls in planning, execution and analysis]. 61
33588461 2021
45
Do Elderly Patients With Diastolic Dysfunction Require Higher Doses of Norepinephrine During General Anesthesia for Noncardiac Surgeries? A Prospective Observational Study. 61
33264119 2021
46
In-hospital outcomes of transcatheter mitral valve repair in patients with and without end stage renal disease: A national propensity match study. 61
33527676 2021
47
Two-dimensional echocardiographic estimates of left ventricular volumes obtained in different views in dogs provide similar measurements but are not interchangeable. 61
33276310 2021
48
Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow's Disease. 61
33671724 2021
49
Straight back syndrome as a clue to diagnosing asymptomatic congenital valvular heart disease and limiting the risk of weightlifting. 61
33567078 2021
50
From Other Journals: A Review of Recent Articles in Pediatric Cardiology. 61
33025027 2021
Sources

Variations for Mitral Valve Disease

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ClinVar genetic disease variations for Mitral Valve Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 6 genes GRCh37/hg19 1q41(chr1:215829463-219225857) copy number loss Pathogenic 523271 GRCh37: 1:215829463-219225857
GRCh38:
Sources

Expression for Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.
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Pathways for Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 63
Show member pathways
 13.54 TGFB3 TGFB2 IL4 IL10 CXCR4 AKT1
2
Integrin Pathway 63
Show member pathways
 13.39 TGFB3 TGFB2 PTK2 MMP13 MMP1 FBN1
3
Akt Signaling 63
Show member pathways
 13.39 TGFB3 TGFB2 PTK2 NOS3 IL4 IL10
4
PAK Pathway 63
Show member pathways
 13.29 TGFB3 TGFB2 PTK2 IL4 IL10 CXCR4
5
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 12.99 TGFB3 TGFB2 NPPB NPPA NOS3 AKT1
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.9 TGFB3 TGFB2 PTK2 NOS3 MMP1 IL10
7
p70S6K Signaling 63
Show member pathways
 12.81 TGFB3 TGFB2 PTK2 IL4 AKT1 AGTR1
8
Development Angiotensin activation of ERK 23
Show member pathways
 12.75 PTK2 NOS3 CXCR4 AKT1 AGTR1 AGT
9
Degradation of the extracellular matrix 65
Show member pathways
 12.74 TGFB3 TGFB2 MMP13 MMP1 FBN1
10
Relaxin signaling pathway 36
Show member pathways
 12.66 PTK2 NOS3 MMP13 MMP1 AKT1
11
Immune response IL-23 signaling pathway 23
Show member pathways
 12.57 PTK2 NOS3 IL10 AKT1 AGTR1
12
Oxytocin signaling pathway 36
Show member pathways
 12.47 NPPB NPPA NOS3 AGTR1 AGT
13
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.44 TGFB3 TGFB2 NPPB NPPA AKT1
14
JAK-STAT signaling pathway 36
Show member pathways
 12.37 IL4 IL10 CXCR4 AKT1 AGTR1
15
cGMP-PKG signaling pathway 36
Show member pathways
 12.35 NPPB NPPA NOS3 AKT1 AGTR1 AGT
16
IL-17 Family Signaling Pathways 64
Show member pathways
 12.33 MMP13 MMP1 IL4 AKT1
17
Pathways in cancer 36
12.33 TGFB3 TGFB2 PTK2 MMP1 IL4 CXCR4
18
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.29 PTK2 MMP13 MMP1 AKT1
19
Dilated cardiomyopathy 36
Show member pathways
 12.25 TGFB3 TGFB2 AGT ACE
20
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.25 TGFB3 TGFB2 IL4 IL10 AKT1
21
Tuberculosis 36
12.23 TGFB3 TGFB2 IL10 AKT1
22
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.22 SLC6A4 PTK2 NOS3 CXCR4 AKT1
23
Colorectal Cancer Metastasis 63
12.18 TGFB3 TGFB2 MMP1 AKT1
24
Toxoplasmosis 36
Show member pathways
 12.17 TGFB3 TGFB2 IL4 IL10 AKT1
25
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 12.16 NPPB NPPA AKT1 AGT
26
FoxO signaling pathway 36
Show member pathways
 12.07 TGFB3 TGFB2 IL10 AKT1
27
Interleukin-4 and 13 signaling 65
11.94 MMP1 IL4 IL10 AKT1
28
Amoebiasis 36
11.88 TGFB3 TGFB2 PTK2 IL10
29
VEGF Pathway (Tocris) 69
Show member pathways
 11.8 PTK2 NOS3 AKT1
30
Angiogenesis (CST) 4
11.8 TGFB3 TGFB2 NOS3 MMP13
31
Glucocorticoid receptor regulatory network 1
11.79 MMP1 IL4 AKT1
32
CXCR4-mediated signaling events 1
11.75 PTK2 CXCR4 AKT1
33
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 60
Show member pathways
 11.74 NOS3 AGTR1 AGT ACE
34
Elastic fibre formation 65
Show member pathways
 11.73 TGFB3 TGFB2 FBN1
35
Endochondral Ossification 1
11.67 TGFB2 MMP13 AKT1
36
IL4-mediated signaling events 1
11.65 IL4 IL10 AKT1
37
Renin secretion 36
11.62 NPPA AGTR1 AGT ACE
38
IL-2 Gene Expression in Activated and Quiescent T-Cells 63
Show member pathways
 11.6 TGFB3 TGFB2 PTK2 AKT1
39
IgA-Producing B Cells in the Intestine 64
11.58 TGFB3 TGFB2 IL4 IL10
40
AGE/RAGE pathway 1
11.55 NOS3 MMP13 AKT1 AGER
41
Malaria 36
11.54 TGFB3 TGFB2 IL10
42
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.36 TGFB3 TGFB2 IL10
43
Extracellular vesicle-mediated signaling in recipient cells 1
11.24 TGFB3 TGFB2 AKT1
44
AGE-RAGE signaling pathway in diabetic complications 36
11.17 TGFB3 TGFB2 NOS3 AKT1 AGTR1 AGT
45
Angiogenesis (WikiPathways) 1
11.11 PTK2 NOS3 AKT1
46
G-protein signaling_Rap2B regulation pathway 23
11 TGFB3 TGFB2 PTK2 IL4 IL10 FBN1
47
IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.93 TGFB3 TGFB2 IL4
48
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.66 TGFB3 TGFB2 IL4
Sources

GO Terms for Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TGFB3 TGFB2 NPPB NPPA MMP13 MMP1
2 collagen-containing extracellular matrix GO:0062023 9.55 TGFB3 TGFB2 NPPA FBN1 AGT
3 extracellular space GO:0005615 9.36 TGFB3 TGFB2 NPPB NPPA MMP13 MIR423

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.03 TGFB3 TGFB2 PTK2 IL4 AKT1 AGT
2 cellular protein metabolic process GO:0044267 9.94 NPPA MMP13 MMP1 FBN1
3 aging GO:0007568 9.91 TGFB3 IL10 AKT1 AGT
4 response to organic substance GO:0010033 9.83 SLC6A4 IL10 AKT1
5 cellular response to mechanical stimulus GO:0071260 9.82 NPPA AKT1 AGT
6 negative regulation of cell growth GO:0030308 9.81 TGFB2 NPPB NPPA AGT
7 regulation of cell proliferation GO:0042127 9.8 TGFB3 TGFB2 PTK2 AGTR1 AGT
8 positive regulation of cell cycle GO:0045787 9.74 TGFB2 SLC6A4 IL10
9 blood vessel remodeling GO:0001974 9.72 NOS3 AGT ACE
10 kidney development GO:0001822 9.72 TGFB2 FBN1 AGTR1 AGT ACE
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL4 IL10
12 cGMP biosynthetic process GO:0006182 9.65 NPPB NPPA
13 receptor guanylyl cyclase signaling pathway GO:0007168 9.64 NPPB NPPA
14 positive regulation of cholesterol esterification GO:0010873 9.63 AGTR1 AGT
15 response to fluid shear stress GO:0034405 9.63 NOS3 AKT1
16 vasodilation GO:0042311 9.63 NPPA NOS3 AGT
17 response to hypoxia GO:0001666 9.63 TGFB3 TGFB2 SLC6A4 NPPA CXCR4 AGER
18 salivary gland morphogenesis GO:0007435 9.62 TGFB3 TGFB2
19 regulation of complement-dependent cytotoxicity GO:1903659 9.62 TGFB2 IL10
20 positive regulation of NAD(P)H oxidase activity GO:0033864 9.61 AGTR1 AGT
21 regulation of vasoconstriction GO:0019229 9.61 AGTR1 AGT ACE
22 type 2 immune response GO:0042092 9.6 IL4 IL10
23 negative regulation of macrophage cytokine production GO:0010936 9.59 TGFB3 TGFB2
24 regulation of renal sodium excretion GO:0035813 9.58 AGTR1 AGT
25 renin-angiotensin regulation of aldosterone production GO:0002018 9.58 AGTR1 AGT
26 regulation of isotype switching GO:0045191 9.54 IL4 IL10
27 positive regulation of cellular protein metabolic process GO:0032270 9.54 AKT1 AGTR1 AGT
28 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGTR1 AGT
29 uterine wall breakdown GO:0042704 9.49 TGFB3 TGFB2
30 regulation of renal output by angiotensin GO:0002019 9.48 AGT ACE
31 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 AGTR1 AGT ACE
32 regulation of blood vessel diameter GO:0097746 9.26 NPPB NOS3 AGTR1 ACE
33 regulation of blood pressure GO:0008217 9.02 NPPB NPPA NOS3 AGT ACE

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 TGFB3 TGFB2 IL4 IL10
2 hormone activity GO:0005179 9.46 NPPB NPPA FBN1 AGT
3 type II transforming growth factor beta receptor binding GO:0005114 9.37 TGFB3 TGFB2
4 hormone receptor binding GO:0051427 9.32 NPPB NPPA
5 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB3 TGFB2
6 growth factor activity GO:0008083 9.02 TGFB3 TGFB2 IL4 IL10 AGT
7 bradykinin receptor binding GO:0031711 8.96 AGTR1 ACE
Sources

Sources for Mitral Valve Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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