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MCID: MTR012
MIFTS: 58

Mitral Valve Disease

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mitral Valve Disease

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MalaCards integrated aliases for Mitral Valve Disease:

Name: Mitral Valve Disease 12 55 15
Abnormality of the Mitral Valve 29 6
Chronic Rheumatic Mitral Valve 12 73
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Rheumatic Mitral Insufficiency 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 73
Diseases of Mitral Valve 73
Disease of Mitral Valve 12
Mitral Rh Valve Dis. 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:61
ICD9CM 35 394 394.1 424.0
NCIt 50 C78446
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Summaries for Mitral Valve Disease

About this section
MalaCards based summary : Mitral Valve Disease, also known as abnormality of the mitral valve, is related to orthostatic intolerance and atrial fibrillation. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are TGF-Beta Pathway and Integrin Pathway. The drugs Metoprolol and Morphine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 32.4 AGTR1 FBN1 NOS3
2 atrial fibrillation 31.3 ACE AGT AGTR1 NPPA
3 mitral valve insufficiency 30.7 ACE CRELD1 FBN1 NPPA
4 pulmonary hypertension 30.6 ACE NOS3 NPPA SLC6A4 TPH1
5 coronary artery anomaly 30.3 ACE AGTR1 NOS3 NPPA
6 pulmonary hypertension, primary, 1 30.2 FBN1 NPPA SLC6A4
7 arteries, anomalies of 30.2 ACE AGT AGTR1 NOS3
8 aortic coarctation 30.1 ACE AGT AGTR1 FBN1 NOS3
9 aortic aneurysm, familial thoracic 1 30.0 FBN1 MMP1 TGFB2
10 aortic aneurysm 30.0 FBN1 MMP13 TGFB2
11 end stage renal failure 30.0 ACE AGT AGTR1
12 hyperlucent lung 29.9 IL10 IL4
13 rheumatic heart disease 29.9 ACE IL10 IL4
14 heart disease 29.8 ACE AGTR1 CRELD1 IL10 NOS3 NPPA
15 pulmonary edema 29.8 ACE IL10 NOS3 NPPA
16 dilated cardiomyopathy 29.7 ACE AGT AGTR1 IL10 MMP1 NOS3
17 hypertension, essential 29.7 ACE AGT AGTR1 NOS3 NPPA
18 myocardial infarction 29.4 ACE AGT AGTR1 CXCR4 IL10 NOS3
19 diabetes mellitus, noninsulin-dependent 29.3 ACE AGT AGTR1 AKT1 NOS3
20 cardiac valvular dysplasia, x-linked 11.6
21 mitral valve stenosis 11.5
22 loeys-dietz syndrome 5 11.3
23 congestive heart failure 10.5
24 tricuspid valve insufficiency 10.4
25 pediatric hypertension 10.2 ACE AGT
26 hypoaldosteronism 10.2 ACE NPPA
27 autoimmune atherosclerosis 10.2 ACE IL10
28 chronic actinic dermatitis 10.2 FBN1 MMP1
29 loeys-dietz syndrome 10.2 FBN1 TGFB2 TGFB3
30 tuberculoid leprosy 10.2 IL10 TGFB2 TGFB3
31 postural orthostatic tachycardia syndrome 10.2 AGTR1 FBN1
32 familial hypertension 10.2 AGT AGTR1 NPPA
33 posterior urethral valves 10.2 ACE AGT AGTR1
34 microvascular complications of diabetes 3 10.2 ACE AGT AGTR1
35 anuria 10.2 ACE AGT AGTR1
36 fibromuscular dysplasia 10.2 ACE AGT AGTR1
37 renal tubular dysgenesis 10.2 ACE AGT AGTR1
38 oligohydramnios 10.2 ACE AGT AGTR1
39 tropical endomyocardial fibrosis 10.2 IL10 IL4
40 bone chondrosarcoma 10.2 MMP1 MMP13
41 endomyocardial fibrosis 10.2 IL10 IL4
42 renal dysplasia 10.1 ACE AGT AGTR1
43 vasculogenic impotence 10.1 ACE NOS3 NPPA
44 acute mountain sickness 10.1 ACE AGTR1 NOS3
45 nonarteritic anterior ischemic optic neuropathy 10.1 ACE AGTR1 NOS3
46 endocarditis 10.1
47 autoimmune myocarditis 10.1 IL4 NPPA
48 aortic valve disease 2 10.1 ACE AGT NPPA
49 otosclerosis 10.1 ACE AGT AGTR1
50 inguinal hernia 10.1 FBN1 MMP1 MMP13

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 86)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Angina Pectoris
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Constrictive Pericarditis Coronary Artery Aneurysm
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Dressler's Syndrome Dyskinesia of Esophagus
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertrophic Cardiomyopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypothyroidism
Idiopathic Interstitial Pneumonia Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease
Sources

Symptoms & Phenotypes for Mitral Valve Disease

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MGI Mouse Phenotypes related to Mitral Valve Disease:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.51 ACE ADAM17 AGT AGTR1 AKT1 CRELD1
2 homeostasis/metabolism MP:0005376 10.45 ACE ADAM17 AGT AGTR1 AKT1 CXCR4
3 growth/size/body region MP:0005378 10.43 ACE ADAM17 AGT AGTR1 AKT1 CXCR4
4 cellular MP:0005384 10.39 ADAM17 AKT1 CRELD1 CXCR4 FBN1 IL10
5 hematopoietic system MP:0005397 10.32 ACE ADAM17 AGTR1 AKT1 CXCR4 FBN1
6 immune system MP:0005387 10.32 ACE ADAM17 AGT AGTR1 AKT1 CXCR4
7 behavior/neurological MP:0005386 10.29 ACE AGT AGTR1 AKT1 FBN1 IL10
8 endocrine/exocrine gland MP:0005379 10.28 ACE ADAM17 AKT1 CXCR4 FBN1 IL10
9 mortality/aging MP:0010768 10.28 ACE ADAM17 AGT AGTR1 AKT1 CRELD1
10 adipose tissue MP:0005375 10.25 ACE AGT AGTR1 AKT1 CXCR4 FBN1
11 embryo MP:0005380 10.2 ADAM17 AKT1 CRELD1 CXCR4 FBN1 IL10
12 muscle MP:0005369 10.15 ADAM17 AGT AKT1 CXCR4 FBN1 IL10
13 nervous system MP:0003631 10.13 ADAM17 AGT AGTR1 AKT1 CRELD1 CXCR4
14 craniofacial MP:0005382 10.11 CRELD1 CXCR4 FBN1 IL10 IL4 TGFB2
15 integument MP:0010771 10.11 ADAM17 AKT1 CXCR4 FBN1 IL10 IL4
16 digestive/alimentary MP:0005381 10.1 ADAM17 CXCR4 IL10 IL4 NOS3 TGFB2
17 limbs/digits/tail MP:0005371 9.98 ADAM17 FBN1 IL10 MMP13 NOS3 TGFB2
18 renal/urinary system MP:0005367 9.91 ACE AGT AGTR1 CXCR4 FBN1 IL4
19 reproductive system MP:0005389 9.9 ACE ADAM17 AGT AKT1 CXCR4 FBN1
20 respiratory system MP:0005388 9.65 ADAM17 AKT1 CXCR4 FBN1 IL10 IL4
21 skeleton MP:0005390 9.36 ADAM17 AKT1 CXCR4 FBN1 IL10 IL4
Sources

Drugs & Therapeutics for Mitral Valve Disease

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Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Racepinephrine Approved Phase 4 329-65-7 838
9 Peripheral Nervous System Agents Phase 4,Phase 2
10 Anti-Arrhythmia Agents Phase 4,Phase 2
11 Analgesics Phase 4,Phase 2
12 Anesthetics, Local Phase 4,Phase 2
13 Anesthetics Phase 4,Phase 2
14 Central Nervous System Depressants Phase 4,Phase 2
15 Analgesics, Non-Narcotic Phase 4,Phase 2
16 Pharmaceutical Solutions Phase 4,Not Applicable
17 Antihypertensive Agents Phase 4
18 Adrenergic Agents Phase 4
19 Autonomic Agents Phase 4
20 Adrenergic Antagonists Phase 4
21 Adrenergic beta-1 Receptor Antagonists Phase 4
22 Neurotransmitter Agents Phase 4
23 Sympatholytics Phase 4
24 Adrenergic beta-Antagonists Phase 4,Not Applicable
25 Narcotics Phase 4
26 Analgesics, Opioid Phase 4
27 Anesthetics, General Phase 4
28 Antipyretics Phase 4
29 Epinephryl borate Phase 4
30 Carticaine Phase 4
31
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
32 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
33 Phosphodiesterase Inhibitors Phase 2, Phase 3
34 Vasodilator Agents Phase 2, Phase 3
35 Citrate Phase 2, Phase 3
36 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
37 Micronutrients Phase 2, Phase 3
38 glutamine Phase 2, Phase 3
39 Trace Elements Phase 2, Phase 3
40 Omega 3 Fatty Acid Phase 2, Phase 3
41
Ketorolac Approved Phase 2 66635-83-4, 74103-06-3 3826
42
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
44 Anti-Inflammatory Agents, Non-Steroidal Phase 2
45 Ketorolac Tromethamine Phase 2
46 Diuretics, Potassium Sparing Phase 2
47 Sodium Channel Blockers Phase 2
48 Antirheumatic Agents Phase 2
49 Anti-Inflammatory Agents Phase 2
50 Cyclooxygenase Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
2 General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function Recruiting NCT03013075 Phase 4 Bupivacaine heavy and Morphine;General Anesthetics
3 ESP vs ESP With PECS Recruiting NCT03592485 Phase 4 Oxycodone;paracetamol
4 Postoperative Analgesia After Minithoracotomy Recruiting NCT03415555 Phase 4 Oxycodone;paracetamol
5 Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Terminated NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
6 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
7 Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
8 Edwards PASCAL CLASP IID Pivotal Clinical Trial Recruiting NCT03706833 Phase 3
9 Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial) Active, not recruiting NCT02435303 Phase 2, Phase 3 Sildenafil;Placebo
10 Preoperative Oral Immunonutrition and Cardiac Patients Active, not recruiting NCT03445221 Phase 2, Phase 3
11 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
12 Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery Completed NCT01481350 Phase 2 sildenafil
13 Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation Completed NCT00807040 Phase 2
14 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
15 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery Unknown status NCT02374229 Phase 1
16 St. Jude Medical Percutaneous Mitral Valve Repair Study Completed NCT01500148 Phase 1
17 Mitral Implantation of TRAnscatheter vaLves Active, not recruiting NCT02370511 Phase 1
18 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524 Not Applicable
19 Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring Unknown status NCT01987635 Not Applicable
20 Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5% Unknown status NCT01849757 Not Applicable
21 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Unknown status NCT02804321
22 Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry Unknown status NCT02039622
23 Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease Completed NCT03278574 Not Applicable
24 Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery Completed NCT01646541
25 The Effectiveness of Respiratory Physiotherapy in Mitral Valve Surgery Completed NCT02278835 Not Applicable
26 Safety and Performance Study of the NeoChord Device Completed NCT01777815 Not Applicable
27 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Completed NCT01246947 Not Applicable
28 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262 Not Applicable
29 Identifying an Ideal Cardiopulmonary Exercise Test Parameter Completed NCT01162083
30 Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR Completed NCT02371863
31 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
32 Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery Recruiting NCT02925819
33 A Modified Cox-Maze Operation for the Treatment of Permanent Atrial Fibrillation With Mitral Valve Disease Recruiting NCT03347695 Not Applicable
34 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study Recruiting NCT03155373
35 PRESERVE-MITRAL Post-Market Registry Recruiting NCT03283722
36 Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Mitral Valve Surgery Recruiting NCT03697941
37 Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach Recruiting NCT03195595
38 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552 Not Applicable
39 Registry for Mitral Valve Surgery at Department of Cardiac Surgery University Hospital of Basel/ Switzerland Recruiting NCT03587688
40 AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System Recruiting NCT03339115 Not Applicable
41 Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders Recruiting NCT03365453 Not Applicable
42 Early Initiation of Post Sternotomy CArdiac Rehabilitation Recruiting NCT03223558 Not Applicable
43 Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair Recruiting NCT02803957 Not Applicable
44 STS/ACC TVT Registry Mitral Module Recruiting NCT02245763
45 MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery Recruiting NCT03012178
46 PARTNER 3 Trial - Mitral Valve in Valve Recruiting NCT03193801 Not Applicable
47 PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients Recruiting NCT03438825
48 Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
49 Improving Mitral Repair for Functional Mitral Regurgitation Recruiting NCT03366649 Not Applicable
50 Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation Recruiting NCT03433274 Not Applicable

Search NIH Clinical Center for Mitral Valve Disease

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Genetic Tests for Mitral Valve Disease

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Genetic tests related to Mitral Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 29
Sources

Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

41
Heart, Testes, Lung, Endothelial, Kidney, Skin, Bone
Sources

Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50) (show all 926)
# Title Authors Year
1
Prosthesis selection for repair of degenerative mitral valve disease. ( 29866534 )
2019
2
Pulmonary Hypertension in Aortic and Mitral Valve Disease. ( 29876357 )
2018
3
Causes of repair failure for degenerative mitral valve disease and reoperation outcomes. ( 29309559 )
2018
4
Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. ( 29390969 )
2018
5
Polymorphism, coupling interval and prematurity index in dogs with degenerative mitral valve disease and ventricular arrhythmias. ( 29536334 )
2018
6
Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease. ( 29200408 )
2018
7
[Corrigendum] Differences in atrial fibrillationa89associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis. ( 29956758 )
2018
8
Simple versus complex degenerative mitral valve disease. ( 29709354 )
2018
9
Regional Left Ventricular Myocardial Mechanics in Degenerative Myxomatous Mitral Valve Disease: A Comparison Between Fibroelastic Deficiency and Barlow's Disease. ( 29361488 )
2018
10
Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease. ( 29315310 )
2018
11
Repair for rheumatic mitral valve disease. The controversy goes on! ( 29331985 )
2018
12
Application of left ventricular strain in patients with aortic and mitral valve disease. ( 29889664 )
2018
13
Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration. ( 29428085 )
2018
14
Long-term results of suture annuloplasty for degenerative mitral valve disease: a propensity-matched analysis. ( 29206693 )
2018
15
Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. ( 29214723 )
2018
16
Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease. ( 29572938 )
2018
17
Echocardiographic Estimates of Right Ventricular Systolic Function in Dogs with Myxomatous Mitral Valve Disease. ( 29224256 )
2018
18
Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease: Results From the Registry of Pregnancy and Cardiac Disease. ( 29459466 )
2018
19
Left atrial deformation and phasic function determined by two-dimensional speckle-tracking echocardiography in dogs with myxomatous mitral valve disease. ( 29459124 )
2018
20
Future Technology of Mitral Valve Repair and Replacement for Mitral Valve Disease. ( 29897014 )
2018
21
Effects of the angiotensin-converting enzyme inhibitor alacepril in dogs with mitral valve disease. ( 29937457 )
2018
22
Bileaflet pericardial patch repair for rheumatic mitral valve disease. ( 29943524 )
2018
23
Giant coronary sinus secondary to partial anomalous pulmonary venous connection with combined mitral valve disease. ( 29593822 )
2018
24
Rate of left ventricular pressure change by Doppler echocardiography in dogs with chronic mitral valve disease at different stages of congestive heart failure. ( 30184293 )
2018
25
Effect of prespecified therapy escalation on plasma NT-proBNP concentrations in dogs with stable congestive heart failure due to myxomatous mitral valve disease. ( 30216549 )
2018
26
A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure. ( 30511765 )
2018
27
A prospective randomized trial of the cut-and-sew Maze procedure in patients undergoing surgery for rheumatic mitral valve disease. ( 28965725 )
2018
28
Filamin A mitral valve disease: prolapse, dystrophy, or dysplasia? ( 29040517 )
2018
29
Risk Factors of Recurrence of Atrial Fibrillation (AF) After AF Surgery in Patients With AF and Mitral Valve Disease. ( 29410135 )
2018
30
Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease. ( 29420783 )
2018
31
QT instability, an indicator of augmented arrhythmogenesis, increases with the progression of myxomatous mitral valve disease in dogs. ( 30031743 )
2018
32
Anesthetic Considerations for the Transcatheter Management of Mitral Valve Disease. ( 30064851 )
2018
33
A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease. ( 30084228 )
2018
34
Is it worth repairing rheumatic mitral valve disease in children? Long-term outcomes of an aggressive approach to rheumatic mitral valve repair compared to replacement in young patients. ( 30085022 )
2018
35
Case 4 - A 59-Year-Old Woman with Rheumatic Mitral Valve Disease (Severe Stenosis and Regurgitation), Severe Dyspnea, Shock and Pulmonary Condensation. ( 30183990 )
2018
36
Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker. ( 30237979 )
2018
37
Changes of body composition after valve surgery in patients with mitral valve disease. ( 30240396 )
2018
38
Diagnostic value of vertebral left atrial size as determined from thoracic radiographs for assessment of left atrial size in dogs with myxomatous mitral valve disease. ( 30272515 )
2018
39
Assessment of plasma lactate and core-peripheral temperature gradient in association with stages of naturally occurring myxomatous mitral valve disease in dogs. ( 30294857 )
2018
40
Association of matrix metalloproteinase 3 and endogenous inhibitors with inflammatory markers in mitral valve disease and calcification. ( 30302620 )
2018
41
Incidentally detected right aortic arch with mirror image branching in a patient with rheumatic calcific mitral valve disease. ( 30348918 )
2018
42
Sex Differences in the Etiology of Surgical Mitral Valve Disease. ( 30354470 )
2018
43
Prognostic factors in dogs with presumed degenerative mitral valve disease attending primary-care veterinary practices in the United Kingdom. ( 30357909 )
2018
44
Functional Tricuspid Regurgitation in Mitral Valve Disease. ( 30382771 )
2018
45
Concomitant Left Atrial Reduction in Rheumatic Mitral Valve Disease With Giant Left Atrium: Our Technique With Midterm Results. ( 30418299 )
2018
46
Iron status in dogs with myxomatous mitral valve disease. ( 30468339 )
2018
47
All-in-One procedure: simultaneous percutaneous treatment of aortic and mitral valve disease in inoperable patient. ( 30468362 )
2018
48
Genome-wide association study of degenerative mitral valve disease in Maltese dogs. ( 30541184 )
2018
49
Correlation between serum homocysteine concentration and severity of mitral valve disease in dogs. ( 28345991 )
2017
50
Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging. ( 28540065 )
2017
Sources

Variations for Mitral Valve Disease

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ClinVar genetic disease variations for Mitral Valve Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ESRRG; GPATCH2; RRP15; SPATA17; TGFB2; USH2A GRCh37/hg19 1q41(chr1: 215829463-219225857) copy number loss Pathogenic GRCh37 Chromosome 1, 215829463: 219225857
Sources

Expression for Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.
Sources

Pathways for Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.43 AGT AGTR1 AKT1 CXCR4 IL10 IL4
2
Integrin Pathway 64
Show member pathways
 13.35 AKT1 CXCR4 FBN1 MMP1 MMP13 TGFB2
3
Akt Signaling 64
Show member pathways
 13.33 AKT1 CXCR4 IL10 IL4 NOS3 RPS6KB1
4
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.82 AGT AKT1 RPS6KB1 TGFB2 TGFB3
5
p70S6K Signaling 64
Show member pathways
 12.64 ACE AGT AGTR1 AKT1 IL4 RPS6KB1
6
Degradation of the extracellular matrix 66
Show member pathways
 12.59 ADAM17 FBN1 MMP1 MMP13 TGFB2 TGFB3
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.52 AGTR1 AKT1 IL10 NOS3 RPS6KB1
8
ErbB signaling pathway 1 37
Show member pathways
 12.44 AKT1 RPS6KB1 TGFB2 TGFB3
9
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.43 AKT1 NPPA TGFB2 TGFB3
10
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.32 AGTR1 AKT1 CXCR4 IL10 IL4
11
IL-17 Family Signaling Pathways 65
Show member pathways
 12.28 AKT1 IL4 MMP1 MMP13
12
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.21 AKT1 IL10 IL4 TGFB2 TGFB3
13
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.19 AKT1 CXCR4 FBN1 MMP1 MMP13
14
Tuberculosis 37
12.18 AKT1 IL10 TGFB2 TGFB3
15
Colorectal Cancer Metastasis 64
12.14 AKT1 MMP1 TGFB2 TGFB3
16
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.02 AKT1 IL10 IL4 TGFB2 TGFB3
17
FoxO signaling pathway 37
Show member pathways
 12.02 AKT1 IL10 TGFB2 TGFB3
18
Apelin signaling pathway 37
12 AGTR1 AKT1 NOS3 RPS6KB1
19
Toxoplasmosis 37
Show member pathways
 11.99 AKT1 IL10 IL4 TGFB2 TGFB3
20
Pathways in cancer 37
11.95 AGTR1 AKT1 CXCR4 IL4 MMP1 RPS6KB1
21
Matrix Metalloproteinases 1
Show member pathways
 11.87 ADAM17 MMP1 MMP13
22
Interleukin-4 and 13 signaling 66
11.87 AKT1 IL10 IL4 MMP1
23
Amoebiasis 37
11.85 IL10 TGFB2 TGFB3
24
Rheumatoid arthritis 37
11.81 MMP1 TGFB2 TGFB3
25
HIF-1 signaling pathway 37
11.8 AKT1 NOS3 NPPA RPS6KB1
26
Jak-Stat Signaling Pathway (sino) 67
11.79 AGTR1 AKT1 CXCR4 IL10
27
IL6-mediated signaling events 1
Show member pathways
 11.78 AGT AKT1 RPS6KB1
28
TGF-beta signaling pathway (KEGG) 37
11.76 RPS6KB1 TGFB2 TGFB3
29
TGF-beta Signaling Pathways 65
11.76 AKT1 RPS6KB1 TGFB2 TGFB3
30
Glucocorticoid receptor regulatory network 1
11.75 AKT1 IL4 MMP1
31
Elastic fibre formation 66
Show member pathways
 11.69 FBN1 TGFB2 TGFB3
32
Angiogenesis (CST) 4
11.68 MMP13 NOS3 TGFB2 TGFB3
33
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.65 AKT1 IL4 RPS6KB1
34
AGE/RAGE pathway 1
11.64 AKT1 MMP13 NOS3
35
Endochondral Ossification 1
11.63 AKT1 MMP13 TGFB2
36
Renin secretion 37
11.62 ACE AGT AGTR1
37
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.61 ACE AGT AGTR1 NOS3
38
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.52 IL10 IL4 TGFB2 TGFB3
39
Malaria 37
11.49 IL10 TGFB2 TGFB3
40
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
11.43 IL10 TGFB2 TGFB3
41
IL4-mediated signaling events 1
11.36 AKT1 IL10 IL4 RPS6KB1
42
G-protein signaling_Cross-talk between Ras-family GTPases 22
11.35 AKT1 RPS6KB1 TGFB2 TGFB3
43
AGE-RAGE signaling pathway in diabetic complications 37
11.35 AGTR1 AKT1 NOS3 TGFB2 TGFB3
44
Extracellular vesicle-mediated signaling in recipient cells 1
11.18 AKT1 TGFB2 TGFB3
45
G-protein signaling_Rap2B regulation pathway 22
10.98 FBN1 IL10 IL4 TGFB2 TGFB3
Sources

GO Terms for Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ACE AGT FBN1 IL10 IL4 MMP13
2 extracellular region GO:0005576 9.65 ACE AGT FBN1 IL10 IL4 MMP1
3 collagen-containing extracellular matrix GO:0062023 9.02 CRELD1 FBN1 NPPA TGFB2 TGFB3

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.98 AGT AKT1 TGFB2 TGFB3
2 response to drug GO:0042493 9.96 ADAM17 IL10 RPS6KB1 SLC6A4 TGFB2
3 cellular protein metabolic process GO:0044267 9.95 FBN1 MMP1 MMP13 NPPA
4 regulation of cell proliferation GO:0042127 9.92 AGT AGTR1 TGFB2 TGFB3
5 response to lipopolysaccharide GO:0032496 9.91 ADAM17 IL10 NOS3 RPS6KB1
6 female pregnancy GO:0007565 9.87 AGT NPPA TGFB3
7 positive regulation of cell growth GO:0030307 9.85 ADAM17 AKT1 TGFB2
8 cellular response to mechanical stimulus GO:0071260 9.85 AGT AKT1 NPPA
9 B cell differentiation GO:0030183 9.84 ADAM17 IL10 IL4
10 response to insulin GO:0032868 9.84 IL10 NPPA RPS6KB1
11 positive regulation of cell cycle GO:0045787 9.8 IL10 SLC6A4 TGFB2
12 regulation of signaling receptor activity GO:0010469 9.8 AGT FBN1 IL10 IL4 NPPA TGFB2
13 response to heat GO:0009408 9.79 AKT1 NOS3 RPS6KB1
14 response to organic substance GO:0010033 9.78 AKT1 IL10 RPS6KB1 SLC6A4
15 positive regulation of blood vessel endothelial cell migration GO:0043536 9.77 ADAM17 AKT1 NOS3
16 aging GO:0007568 9.77 AGT AKT1 IL10 RPS6KB1 TGFB3
17 low-density lipoprotein particle remodeling GO:0034374 9.7 AGT AGTR1
18 pulmonary valve morphogenesis GO:0003184 9.7 NOS3 TGFB2
19 regulation of blood vessel diameter GO:0097746 9.7 ACE AGTR1
20 blood vessel remodeling GO:0001974 9.7 ACE AGT NOS3
21 secondary palate development GO:0062009 9.69 TGFB2 TGFB3
22 nitric oxide biosynthetic process GO:0006809 9.68 AKT1 NOS3
23 cofactor metabolic process GO:0051186 9.67 AKT1 NOS3
24 salivary gland morphogenesis GO:0007435 9.67 TGFB2 TGFB3
25 positive regulation of cholesterol esterification GO:0010873 9.66 AGT AGTR1
26 response to fluid shear stress GO:0034405 9.65 AKT1 NOS3
27 neutrophil mediated immunity GO:0002446 9.65 ACE ADAM17
28 obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.64 ADAM17 AKT1
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
30 positive regulation of NAD(P)H oxidase activity GO:0033864 9.63 AGT AGTR1
31 regulation of vasoconstriction GO:0019229 9.63 ACE AGT AGTR1
32 regulation of blood pressure GO:0008217 9.62 ACE AGT NOS3 NPPA
33 negative regulation of macrophage cytokine production GO:0010936 9.61 TGFB2 TGFB3
34 regulation of blood vessel size GO:0050880 9.61 AGT NOS3 NPPA
35 regulation of isotype switching GO:0045191 9.59 IL10 IL4
36 regulation of renal sodium excretion GO:0035813 9.58 AGT AGTR1
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.58 AGT AGTR1
38 positive regulation of cellular protein metabolic process GO:0032270 9.58 AGT AGTR1 AKT1
39 type 2 immune response GO:0042092 9.57 IL10 IL4
40 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.55 AGT AGTR1
41 kidney development GO:0001822 9.55 ACE AGT AGTR1 FBN1 TGFB2
42 regulation of complement-dependent cytotoxicity GO:1903659 9.54 IL10 TGFB2
43 regulation of renal output by angiotensin GO:0002019 9.51 ACE AGT
44 uterine wall breakdown GO:0042704 9.49 TGFB2 TGFB3
45 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
46 response to hypoxia GO:0001666 9.1 ADAM17 CXCR4 NPPA SLC6A4 TGFB2 TGFB3
47 positive regulation of cell proliferation GO:0008284 10.09 ADAM17 AGT AKT1 TGFB2 TGFB3
48 cytokine-mediated signaling pathway GO:0019221 10 AKT1 IL10 IL4 MMP1

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 IL10 IL4 TGFB2 TGFB3
2 endopeptidase activity GO:0004175 9.58 ACE ADAM17 MMP1
3 metallopeptidase activity GO:0008237 9.56 ACE ADAM17 MMP1 MMP13
4 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFB3
5 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB2 TGFB3
6 growth factor activity GO:0008083 9.02 AGT IL10 IL4 TGFB2 TGFB3
7 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
Sources

Sources for Mitral Valve Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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