MCID: MTR012
MIFTS: 58

Mitral Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Disease

MalaCards integrated aliases for Mitral Valve Disease:

Name: Mitral Valve Disease 12 54 15 17
Abnormality of the Mitral Valve 29 6
Chronic Rheumatic Mitral Valve 12 71
Rheumatic Mitral Insufficiency 12 32
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 71
Diseases of Mitral Valve 71
Disease of Mitral Valve 12
Mitral Rh Valve Dis. 12

Classifications:



External Ids:

Disease Ontology 12 DOID:61
ICD9CM 34 394 394.1 424.0
NCIt 49 C78446
UMLS 71 C0026265 C0155563 C0264765 more

Summaries for Mitral Valve Disease

MalaCards based summary : Mitral Valve Disease, also known as abnormality of the mitral valve, is related to mitral valve stenosis and loeys-dietz syndrome 5. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are TGF-Beta Pathway and Integrin Pathway. The drugs Morphine and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Mitral Valve Disease

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 mitral valve stenosis 33.7 NPPB NPPA ACE
2 loeys-dietz syndrome 5 33.1 TGFB3 TGFB2 FBN1
3 orthostatic intolerance 32.8 TGFB3 TGFB2 NOS3 MIR423 FBN1 AGTR1
4 mitral valve insufficiency 32.0 NPPB NPPA MIR423 FBN1 ACE
5 congestive heart failure 31.5 NPPB NPPA NOS3 AGTR1 AGT ACE
6 atrial fibrillation 31.5 NPPB NPPA NOS3 AGTR1 AGT ACE
7 aortic valve insufficiency 31.4 NPPB FBN1 ACE
8 rheumatic heart disease 31.4 NPPB IL4 IL10 ACE
9 heart valve disease 31.4 NPPB NPPA MIR423 FBN1 ACE
10 rheumatic fever 31.2 NPPB IL10 ACE
11 tricuspid valve disease 31.2 NPPB FBN1 ACE
12 atrial heart septal defect 31.2 NPPB NPPA FBN1 ACE
13 sick sinus syndrome 31.1 NPPA MIR423 AGT
14 marfan syndrome 31.0 TGFB2 MMP1 FBN1 AGTR1
15 pulmonary hypertension 30.9 TPH1 SLC6A4 NPPB NPPA NOS3 IL10
16 aortic dissection 30.9 TGFB3 TGFB2 FBN1
17 arteries, anomalies of 30.8 NOS3 MIR423 AGTR1 ACE
18 aortic disease 30.8 TGFB3 TGFB2 FBN1 ACE
19 lipoprotein quantitative trait locus 30.8 NPPB NPPA NOS3 IL10 AGTR1 ACE
20 aneurysm 30.7 TGFB3 TGFB2 FBN1
21 tricuspid valve prolapse 30.7 TGFB3 TGFB2 FBN1
22 eclampsia 30.7 NOS3 AGT ACE
23 pulmonary edema 30.7 NPPB NPPA NOS3 IL10 AGTR1 AGT
24 coronary stenosis 30.6 NPPB CXCR4 ACE
25 arteriosclerosis 30.5 NOS3 IL4 IL10 FBN1 ACE
26 angina pectoris 30.5 NPPB NOS3 ACE
27 pericardial effusion 30.5 NPPB NPPA ACE
28 migraine with or without aura 1 30.5 TPH1 SLC6A4 NOS3 IL10 ACE
29 end stage renal disease 30.5 NOS3 AGTR1 AGT ACE
30 aortic aneurysm, familial thoracic 1 30.4 TGFB3 TGFB2 MMP1 FBN1 AGTR1
31 aortic aneurysm 30.4 TGFB3 TGFB2 MMP13 FBN1 ACE
32 coronary heart disease 1 30.4 NPPB NOS3 AGTR1 ACE
33 patent ductus arteriosus 1 30.4 NPPB FBN1 ACE
34 chronic kidney disease 30.4 NPPB NPPA NOS3 IL10 AGTR1 AGT
35 respiratory failure 30.3 NPPB NPPA IL10 ACE
36 intracranial aneurysm 30.3 TGFB2 NOS3 ACE
37 myocarditis 30.3 NPPB IL4 IL10 ACE
38 hypoplastic left heart syndrome 30.3 NPPB NPPA ACE
39 acute myocardial infarction 30.2 NPPB NPPA MIR423 AGTR1 ACE
40 dilated cardiomyopathy 30.1 TGFB3 TGFB2 NPPB NPPA NOS3 MMP1
41 lung disease 30.1 NPPB IL4 IL10 CXCR4 ACE
42 hypertrophic cardiomyopathy 30.0 TGFB3 TGFB2 NPPB NPPA NOS3 AKT1
43 kidney disease 30.0 NPPB NPPA NOS3 AGTR1 AGT AGER
44 systemic lupus erythematosus 29.8 NOS3 MIR423 IL4 IL10 CXCR4 AKT1
45 vascular disease 29.8 SLC6A4 NPPB NOS3 IL10 AGTR1 AGT
46 pre-eclampsia 29.8 TGFB3 NPPA NOS3 IL4 IL10 AGTR1
47 heart disease 29.7 TGFB3 SLC6A4 NPPB NPPA NOS3 MIR423
48 stroke, ischemic 29.7 NPPB NPPA NOS3 FBN1 CXCR4 AKT1
49 hypertension, essential 29.0 NPPB NPPA NOS3 MMP1 MIR423 IL4
50 cardiac valvular dysplasia, x-linked 11.4

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 83)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Angina Pectoris
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Pulmonary Heart Disease
Constrictive Pericarditis Coronary Artery Aneurysm
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Dressler's Syndrome Dyskinesia of Esophagus
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hyperlipoproteinemia, Type V Hypertension, Essential
Hypertrophic Cardiomyopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypothyroidism
Idiopathic Interstitial Pneumonia Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease

Symptoms & Phenotypes for Mitral Valve Disease

MGI Mouse Phenotypes related to Mitral Valve Disease:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACE AGER AGT AGTR1 AKT1 CXCR4
2 homeostasis/metabolism MP:0005376 10.45 ACE AGER AGT AGTR1 AKT1 CXCR4
3 growth/size/body region MP:0005378 10.43 ACE AGER AGT AGTR1 AKT1 CXCR4
4 cellular MP:0005384 10.37 AGER AKT1 CXCR4 FBN1 IL10 IL4
5 hematopoietic system MP:0005397 10.32 ACE AGER AGTR1 AKT1 CXCR4 FBN1
6 immune system MP:0005387 10.32 ACE AGER AGT AGTR1 AKT1 CXCR4
7 endocrine/exocrine gland MP:0005379 10.28 ACE AKT1 CXCR4 FBN1 IL10 IL4
8 mortality/aging MP:0010768 10.22 ACE AGT AGTR1 AKT1 CXCR4 FBN1
9 adipose tissue MP:0005375 10.18 ACE AGT AGTR1 AKT1 CXCR4 FBN1
10 integument MP:0010771 10.16 AGER AKT1 CXCR4 FBN1 IL10 IL4
11 digestive/alimentary MP:0005381 10.15 CXCR4 IL10 IL4 NOS3 PTK2 SLC6A4
12 muscle MP:0005369 10.15 AGER AGT AKT1 CXCR4 FBN1 IL10
13 nervous system MP:0003631 10.1 AGT AGTR1 AKT1 CXCR4 FBN1 IL10
14 limbs/digits/tail MP:0005371 9.98 FBN1 IL10 MMP13 NOS3 PTK2 TGFB2
15 renal/urinary system MP:0005367 9.96 ACE AGER AGT AGTR1 CXCR4 FBN1
16 reproductive system MP:0005389 9.85 ACE AGT AKT1 CXCR4 FBN1 IL10
17 respiratory system MP:0005388 9.65 AKT1 CXCR4 FBN1 IL10 IL4 NOS3
18 skeleton MP:0005390 9.36 AGER AKT1 CXCR4 FBN1 IL10 IL4

Drugs & Therapeutics for Mitral Valve Disease

Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Warfarin Approved Phase 4 81-81-2 6691 54678486
3
Enoxaparin Approved Phase 4 9005-49-6 772
4
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
7
Racepinephrine Approved Phase 4 329-65-7 838
8
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
9
Dabigatran Investigational Phase 4 211914-51-1
10 Antithrombins Phase 4
11 Serine Proteinase Inhibitors Phase 4
12 Antithrombin III Phase 4
13
protease inhibitors Phase 4
14 HIV Protease Inhibitors Phase 4
15 Narcotics Phase 4
16 Anesthetics, General Phase 4
17 Analgesics Phase 4
18 Analgesics, Opioid Phase 4
19 Anticoagulants Phase 4
20 Adrenergic beta-Antagonists Phase 4
21 Fibrinolytic Agents Phase 4
22 Adrenergic beta-1 Receptor Antagonists Phase 4
23 Antihypertensive Agents Phase 4
24 Adrenergic Agents Phase 4
25 Neurotransmitter Agents Phase 4
26 Sympatholytics Phase 4
27 Adrenergic Antagonists Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Carticaine Phase 4
30 Pharmaceutical Solutions Phase 4
31 Epinephryl borate Phase 4
32 Anesthetics Phase 4
33 Anesthetics, Local Phase 4
34
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
35
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
36
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
37 Omega 3 Fatty Acid Phase 2, Phase 3
38 Micronutrients Phase 2, Phase 3
39 Trace Elements Phase 2, Phase 3
40 glutamine Phase 2, Phase 3
41 Citrate Phase 2, Phase 3
42 Phosphodiesterase Inhibitors Phase 2, Phase 3
43 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
44 Vasodilator Agents Phase 2, Phase 3
45 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
47
Ketorolac Approved Phase 2 66635-83-4, 74103-06-3 3826
48
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
49 Sodium Channel Blockers Phase 2
50 Analgesics, Non-Narcotic Phase 2

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 The Use of Dabigatran Etexilate in Patients With Atrial Fibrillation After Mitral Valve Prosthetic Replacement Unknown status NCT03183843 Phase 4 Dabigatran Etexilate;Warfarin
2 Comparative Effect of Combined High Spinal and General Anaesthesia With General Anaesthesia Alone On Right Ventricular Function In Patients With Mitral Valvular Disease With Pulmonary Hypertension Unknown status NCT03013075 Phase 4 Bupivacaine heavy and Morphine;General Anesthetics
3 Evaluation of Warfarin Initiation at 3mg Versus 5mg for Anticoagulation of Mechanical Mitral Valve Replacement Patients Completed NCT04235569 Phase 4 Warfarin Sodium 5 MG;Warfarin Sodium 3 MG;Enoxaparin Sodium 100 MG/ML Prefilled Syringe
4 Beta Blockade in Mitral Regurgitation Completed NCT00166400 Phase 4 metoprolol succinate
5 Comparison of Periosteal and Subcutaneous Infusions of Articaine and Bupivacaine in Treatment of Acute Pain After Sternotomy Suspended NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
6 Clinical Investigation Of The Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
7 Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System Compared to Abbott MitraClip in Patients With Mitral Regurgitation Recruiting NCT03706833 Phase 3
8 Implication of Preoperative Immunonutrition Upon Cardiac Patients Undergoing Mitral Valve Replacement Surgery Recruiting NCT03445221 Phase 2, Phase 3
9 The Safety and Effectiveness of the SAPIEN 3 and SAPIEN 3 Ultra Valve in Patients With Symptomatic Severe Calcific Mitral Valve Disease With Severe Mitral Annular Calcification Who Are Not Candidates for Standard Mitral Valve Surgery. Not yet recruiting NCT04408430 Phase 2, Phase 3
10 Effect of Sildenafil for the Treatment of Sustained Pulmonary Artery Hypertension After Corrected Mitral Valve Disease Terminated NCT02435303 Phase 2, Phase 3 Sildenafil;Placebo
11 A Randomized Study of the Effects of Perioperative i.v. Ketorolac-lidocaine on the Hemodynamic Response in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
12 Phase 2 Use of Sildenafil for the Treatment of Post-capillary Hypertension in Patients Undergoing Cardiac Surgery Completed NCT01481350 Phase 2 sildenafil
13 Surgical Ablation Versus No Surgical Ablation for Patients With Persistent or Longstanding Persistent Atrial Fibrillation (AF) Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
14 Evaluation of Outcomes Following Mitral Valve Repair/Replacement in Severe Chronic Ischemic Mitral Regurgitation Completed NCT00807040 Phase 2
15 Surgical Ablation of Ganglion Plexuses of the Pulmonary Artery in Patients With Valvular Heart Disease, Complicated by High Pulmonary Hypertension May Reduce Its Degree. Unknown status NCT02374229 Phase 1
16 Clinical Assessment of the St. Jude Medical (SJM) Percutaneous Mitral Valve Repair (PMVr) Device Concept Completed NCT01500148 Phase 1
17 Comparison Between Outcomes Of Ring And Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
18 A Study to Assess the Effects of Two Commonly Used Mitral Valve Annuloplasty Rings in Mitral Valve Repair on Short-term Outcomes. Unknown status NCT03290872
19 Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring Unknown status NCT01987635
20 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Unknown status NCT02804321
21 Invasive Hemodynamic Stress Test in Symptomatic and Asymptomatic Mitral Regurgitation Unknown status NCT02961647
22 Right Ventricular Function After Mitral Valve Replacement in Rheumatic Heart Disease Patients With Pulmonary Hypertension: Short Term Follow up Unknown status NCT03549052
23 Mitral Valve Repair Using Flexible Bands Versus Complete Rings in Patients With Degenerative Mitral Valve Disease: a Prospective, Randomized Study Completed NCT03278574
24 Safety and Performance Study of the NeoChord Suturing Device in Subjects With Degenerative Mitral Valve Disease; Diagnosed With Severe Mitral Regurgitation Completed NCT01777815
25 Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Mitral Valve Surgery Completed NCT03697941
26 Combining Multiple Complex Modelling Components to Create a Decision Support System for Heart Valve Disease Completed NCT04068740
27 Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease Completed NCT04078867
28 Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery: Pilot, Screening Study Completed NCT01646541
29 A Prospective Randomized Trial of Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Mitral Operation Completed NCT01246947
30 Surgical Treatment of Concomitant Atrial Fibrillation: a Comprehensive Insight Into Biatrial Contractility Recovery. Completed NCT02303652
31 To Analyze the Effectiveness of Respiratory Physiotherapy Techniques in the Post Operative Mitral Valve Completed NCT02278835
32 Assessment of the Effect of Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation in Patients Undergoing Open Heart Surgery Completed NCT03239262
33 Efficacy of Histidine-Tryptophan-Ketoglutarate Solution Versus Blood Cardioplegia in Coronary Artery Bypass Graft Surgery: A Randomized Double Blinded Study Completed NCT04203680 Early Phase 1 HTK cardioplegic solution;blood cardioplegia
34 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Completed NCT03155373
35 Management And Clinical Outcomes Of Patients With Severe Mitral Disease Not Suitable For Surgery: A Prospective, Multicentric, Observational Study Recruiting NCT02925819
36 Registry for Mitral Valve Surgery at Department of Cardiac Surgery University Hospital of Basel/ Switzerland Recruiting NCT03587688
37 The AcChord Study: A Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System Recruiting NCT04190602
38 Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach Recruiting NCT03195595
39 Randomized Trial of the NeoChord™ DS1000™ System Versus Open Surgical Repair Recruiting NCT02803957
40 A Modified Cox-Maze Operation (Left Atrial Circumferential Resection, Isthmic Ablation and Standard Right Maze With Radio Frequency) for the Treatment of Permanent Atrial Fibrillation With Mitral Valve Disease Recruiting NCT03347695
41 Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation Recruiting NCT03433274
42 Prospective Evaluation of MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery: MRI-MVS Study Recruiting NCT03012178
43 The Society of Thoracic Surgeons/ American College of Cardiology Transcatheter Valve Therapies Registry Mitral Module Recruiting NCT02245763
44 Intraoperative Transesophageal Echocardiography in On-pump Mitral Surgery: A Single Center Prospective Observational Study of Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome Recruiting NCT04045340
45 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552
46 Effect of MitraClip on Reverse Cardiac Remodeling Assessed by CMR and Echocardiography: The MITRA-REVERSE Study A Prospective Multicenter Study Recruiting NCT02924363
47 Prospective REgistry to Study Clinical OutcomEs of Repair of Mitral ValvEs in South Asia Active, not recruiting NCT03283722
48 Clinical Investigation of the Caisson Transcatheter Mitral Valve Replacement (TMVR) System for Percutaneous Mitral Valve Replacement in Patients With Symptomatic Mitral Regurgitation Active, not recruiting NCT03661398
49 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
50 Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae Active, not recruiting NCT03674593

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

Genetic tests related to Mitral Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 29

Anatomical Context for Mitral Valve Disease

MalaCards organs/tissues related to Mitral Valve Disease:

40
Heart, Lung, Testes, Endothelial, Brain, Kidney, Skin

Publications for Mitral Valve Disease

Articles related to Mitral Valve Disease:

(show top 50) (show all 3026)
# Title Authors PMID Year
1
Decreased plasma brain natriuretic peptide levels after a successful maze procedure. 54 61
12803326 2003
2
[The influence of electrical cardioversion on left ventricular systolic function, left atrial size, ANP levels and enzymatic activity of CPK and CD-MB in serum of patients with paroxysmal atrial fibrillation]. 54 61
9501676 1997
3
Plasma ANP and cyclic GMP after physical exercise in patients with mitral valve disease and in healthy subjects. 61 54
8225655 1993
4
[Atrial natriuretic peptide in rheumatic mitral valve disease]. 61 54
8351229 1993
5
Correction: Use of radiographic measurements to diagnose stage B2 preclinical myxomatous mitral valve disease in dogs. 61
32538703 2020
6
Racial Differences In the Aetiology of Mitral Valve Disease. 61
32539080 2020
7
Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease. 61
32571097 2020
8
Minimally Invasive Hybrid Approach to High Risk Mitral Disease With Severe Mitral Annular Calcification. 61
32414620 2020
9
Catheter ablation of cavotricuspid isthmus in patients with atrial flutter: predictors of long-term outcomes. 61
32500993 2020
10
Contemporary trends in mitral valve surgery in East China: a 10-year experience. 61
32515208 2020
11
Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy. 61
32175811 2020
12
Functional tricuspid regurgitation of degenerative mitral valve disease: a crucial determinant of survival. 61
32300779 2020
13
Redo MitraClip for Late Recurrent Severe Mitral Regurgitation: Case Report and Literature Review. 61
32462133 2020
14
Perspectives on surgical treatment of mitral valve disease. 61
32469675 2020
15
Use of radiographic measurements to diagnose stage B2 preclinical myxomatous mitral valve disease in dogs. 61
32364449 2020
16
Does isolated mitral annular calcification in the absence of mitral valve disease affect clinical outcomes after transcatheter aortic valve replacement? 61
31408104 2020
17
The playmaker of the mitral valve disease: Mitral annulus. 61
32387253 2020
18
Phenotypic spectrum of TGFB3 disease-causing variants in a Dutch-French cohort and first report of a homozygous patient. 61
31898322 2020
19
Rheumatic mitral valve repair: a personal perspective and results. 61
32436717 2020
20
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. 61
32223336 2020
21
Letter to editor regarding Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study. 61
32442325 2020
22
Does Referral Bias Impact Outcomes of Surgery for Degenerative Mitral Valve Disease? 61
32473837 2020
23
Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study. 61
32200574 2020
24
Stress-induced remodelling of the mitral valve: a model for leaflet thickening and superimposed tissue formation in mitral valve disease. 61
31497851 2020
25
Commissural fusion as etiology of bioprosthetic mitral stenosis in a patient with rheumatic heart disease. 61
32181512 2020
26
Comparison of Mitral Valve Repair versus Replacement for the Progression of Functional Tricuspid Regurgitation. 61
31495812 2020
27
New developments in transcatheter therapy of mitral valve disease. 61
32395315 2020
28
Presentation and management of calcific mitral valve disease. 61
31959408 2020
29
Intermittent mitral regurgitation in Cavalier King Charles spaniels: Short-term progression and influence of stress tests. 61
32564867 2020
30
Cardiac wall motion abnormality as a predictor for undetermined stroke with embolic lesion-pattern. 61
31958700 2020
31
Association of echocardiographic measures of left ventricular diastolic dysfunction and hypertrophy with presence of coronary microvascular dysfunction. 61
32154362 2020
32
Left Atrial End-Diastolic Volume Index as a Predictor of Cardiovascular Outcomes: The Heart and Soul Study. 61
32306763 2020
33
New Technique in Assessment of Heart Chambers Remodeling in Acquired Mitral Valve Defects. 61
32326375 2020
34
Case report: left atrial Myxoma causing elevated C-reactive protein, fatigue and fever, with literature review. 61
32138674 2020
35
Usefulness of pericardial lung ultrasonography for the diagnosis of cardiogenic pulmonary edema in dogs. 61
32101047 2020
36
Acute Pulmonary Edema: A Rare Cause of Dyspnea After Electrical Cardioversion. 61
31973957 2020
37
Interscallop indentation closure as an adjunctive technique in mitral valve repair for degenerative mitral valve disease. 61
31317384 2020
38
Risk for non-home discharge following surgery for ischemic mitral valve disease. 61
32307181 2020
39
Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism. 61
32112596 2020
40
Surgical management of mitral annular calcification. 61
31895243 2020
41
Minimal Access Versus Sternotomy for Complex Mitral Valve Repair: A Meta-Analysis. 61
31479637 2020
42
Early results of robotically assisted mitral valve repair in a single institution: report of the first 100 cases. 61
32072433 2020
43
Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease. 61
31961274 2020
44
Management of patients with newly-diagnosed atrial fibrillation: Insights from the BALKAN-AF survey. 61
32140551 2020
45
Transcatheter mitral valve-in-valve implantation: reports of the first 50 cases from a Latin American Centre. 61
31713609 2020
46
Transseptal Approach for Mitral Valve Replacement in Dextrocardia with Situs Inversus Totalis: A Case Report and Review of the Literature. 61
32118539 2020
47
Functional tricuspid regurgitation in rheumatic mitral valve disease patients with and without tricuspid annuloplasty: a three-dimensional echocardiography study with one year follow up. 61
31598812 2020
48
Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair. 61
32060011 2020
49
Should Moderate Functional Tricuspid Regurgitation be Repaired During Surgery for Rheumatic Mitral Valve Disease? 61
32199778 2020
50
Hemodynamics rounds: Hemodynamics of mitral valve interventions. 61
32034874 2020

Variations for Mitral Valve Disease

ClinVar genetic disease variations for Mitral Valve Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ESRRG , GPATCH2 , RRP15 , SPATA17 , TGFB2 , USH2A GRCh37/hg19 1q41(chr1:215829463-219225857)copy number loss Pathogenic 523271 1:215829463-219225857

Expression for Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for Mitral Valve Disease

Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TGFB3 TGFB2 IL4 IL10 CXCR4 AKT1
2
Show member pathways
13.38 TGFB3 TGFB2 PTK2 MMP13 MMP1 FBN1
3
Show member pathways
13.37 TGFB3 TGFB2 PTK2 NOS3 IL4 IL10
4
Show member pathways
13.28 TGFB3 TGFB2 PTK2 IL4 IL10 CXCR4
5
Show member pathways
12.73 TGFB3 TGFB2 MMP13 MMP1 FBN1
6
Show member pathways
12.69 PTK2 NOS3 CXCR4 AKT1 AGTR1 AGT
7
Show member pathways
12.65 PTK2 NOS3 MMP13 MMP1 AKT1
8
Show member pathways
12.64 TGFB3 TGFB2 PTK2 IL4 AKT1 AGTR1
9
Show member pathways
12.55 PTK2 NOS3 IL10 AKT1 AGTR1
10
Show member pathways
12.44 NPPB NPPA NOS3 AGTR1 AGT
11
Show member pathways
12.43 IL4 IL10 CXCR4 AKT1 AGTR1
12
Show member pathways
12.41 TGFB3 TGFB2 NPPB NPPA AKT1
13 12.33 TGFB3 TGFB2 PTK2 MMP1 IL4 CXCR4
14
Show member pathways
12.32 MMP13 MMP1 IL4 AKT1
15
Show member pathways
12.28 PTK2 MMP13 MMP1 AKT1
16
Show member pathways
12.24 TGFB3 TGFB2 AGT ACE
17
Show member pathways
12.24 TGFB3 TGFB2 IL4 IL10 AKT1
18
Show member pathways
12.23 NPPB NPPA NOS3 AKT1 AGTR1 AGT
19 12.22 TGFB3 TGFB2 IL10 AKT1
20
Show member pathways
12.19 SLC6A4 PTK2 NOS3 CXCR4 AKT1
21 12.17 TGFB3 TGFB2 MMP1 AKT1
22
Show member pathways
12.14 NPPB NPPA AKT1 AGT
23
Show member pathways
12.11 TGFB3 TGFB2 IL4 IL10 AKT1
24
Show member pathways
12.04 TGFB3 TGFB2 IL10 AKT1
25 11.91 MMP1 IL4 IL10 AKT1
26 11.85 TGFB3 TGFB2 PTK2 IL10
27
Show member pathways
11.79 PTK2 NOS3 AKT1
28 11.78 MMP1 IL4 AKT1
29 11.76 TGFB3 TGFB2 NOS3 MMP13
30 11.74 PTK2 CXCR4 AKT1
31
Show member pathways
11.72 TGFB3 TGFB2 FBN1
32
Show member pathways
11.7 NOS3 AGTR1 AGT ACE
33 11.66 TGFB2 MMP13 AKT1
34 11.64 IL4 IL10 AKT1
35
Show member pathways
11.57 TGFB3 TGFB2 PTK2 AKT1
36 11.54 NPPA AGTR1 AGT ACE
37 11.53 TGFB3 TGFB2 IL10
38 11.49 NOS3 MMP13 AKT1 AGER
39
Show member pathways
11.33 TGFB3 TGFB2 IL10
40 11.21 TGFB3 TGFB2 AKT1
41 11.17 TGFB3 TGFB2 NOS3 AKT1 AGTR1 AGT
42 11.08 PTK2 NOS3 AKT1
43 10.97 TGFB3 TGFB2 PTK2 IL4 IL10 FBN1
44 10.88 TGFB3 TGFB2 IL4
45 10.58 TGFB3 TGFB2 IL4

GO Terms for Mitral Valve Disease

Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TGFB3 TGFB2 NPPB NPPA MMP13 MMP1
2 collagen-containing extracellular matrix GO:0062023 9.55 TGFB3 TGFB2 NPPA FBN1 AGT
3 extracellular space GO:0005615 9.36 TGFB3 TGFB2 NPPB NPPA MMP13 MIR423

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.02 TGFB3 TGFB2 PTK2 IL4 AKT1 AGT
2 extracellular matrix organization GO:0030198 9.97 PTK2 MMP13 MMP1 FBN1
3 cellular protein metabolic process GO:0044267 9.94 NPPA MMP13 MMP1 FBN1
4 aging GO:0007568 9.91 TGFB3 IL10 AKT1 AGT
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 TGFB2 PTK2 AGT
6 cellular response to mechanical stimulus GO:0071260 9.83 NPPA AKT1 AGT
7 negative regulation of cell growth GO:0030308 9.83 TGFB2 NPPB NPPA AGT
8 regulation of cell proliferation GO:0042127 9.83 TGFB3 TGFB2 PTK2 AGTR1 AGT
9 negative regulation of autophagy GO:0010507 9.77 PTK2 IL10 AKT1
10 positive regulation of cell cycle GO:0045787 9.76 TGFB2 SLC6A4 IL10
11 kidney development GO:0001822 9.72 TGFB2 FBN1 AGTR1 AGT ACE
12 blood vessel remodeling GO:0001974 9.69 NOS3 AGT ACE
13 cofactor metabolic process GO:0051186 9.67 NOS3 AKT1
14 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.67 IL4 IL10
15 cGMP biosynthetic process GO:0006182 9.66 NPPB NPPA
16 negative regulation of organ growth GO:0046621 9.65 SLC6A4 PTK2
17 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL4 IL10
18 salivary gland morphogenesis GO:0007435 9.65 TGFB3 TGFB2
19 receptor guanylyl cyclase signaling pathway GO:0007168 9.64 NPPB NPPA
20 response to fluid shear stress GO:0034405 9.63 NOS3 AKT1
21 positive regulation of cholesterol esterification GO:0010873 9.63 AGTR1 AGT
22 regulation of vasoconstriction GO:0019229 9.63 AGTR1 AGT ACE
23 response to hypoxia GO:0001666 9.63 TGFB3 TGFB2 SLC6A4 NPPA CXCR4 AGER
24 regulation of complement-dependent cytotoxicity GO:1903659 9.62 TGFB2 IL10
25 positive regulation of NAD(P)H oxidase activity GO:0033864 9.62 AGTR1 AGT
26 type 2 immune response GO:0042092 9.61 IL4 IL10
27 negative regulation of macrophage cytokine production GO:0010936 9.59 TGFB3 TGFB2
28 regulation of isotype switching GO:0045191 9.58 IL4 IL10
29 vasodilation GO:0042311 9.58 NPPA NOS3 AGT
30 regulation of renal sodium excretion GO:0035813 9.57 AGTR1 AGT
31 renin-angiotensin regulation of aldosterone production GO:0002018 9.56 AGTR1 AGT
32 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.54 AGTR1 AGT
33 positive regulation of cellular protein metabolic process GO:0032270 9.54 AKT1 AGTR1 AGT
34 uterine wall breakdown GO:0042704 9.49 TGFB3 TGFB2
35 regulation of renal output by angiotensin GO:0002019 9.48 AGT ACE
36 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 AGTR1 AGT ACE
37 regulation of blood vessel diameter GO:0097746 9.26 NPPB NOS3 AGTR1 ACE
38 regulation of blood pressure GO:0008217 9.02 NPPB NPPA NOS3 AGT ACE

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 TGFB3 TGFB2 IL4 IL10
2 hormone activity GO:0005179 9.46 NPPB NPPA FBN1 AGT
3 type II transforming growth factor beta receptor binding GO:0005114 9.37 TGFB3 TGFB2
4 hormone receptor binding GO:0051427 9.32 NPPB NPPA
5 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB3 TGFB2
6 growth factor activity GO:0008083 9.02 TGFB3 TGFB2 IL4 IL10 AGT
7 bradykinin receptor binding GO:0031711 8.96 AGTR1 ACE

Sources for Mitral Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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