MCID: MTR002
MIFTS: 48

Mitral Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Insufficiency

MalaCards integrated aliases for Mitral Valve Insufficiency:

Name: Mitral Valve Insufficiency 12 44 15 73
Mitral Regurgitation 12 29 55 6 15
Congenital Insufficiency of Mitral Valve 12 73
Congenital Mitral Insufficiency 12
Congenital Mitral Regurgitation 12
Mitral Valve Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11502
ICD10 33 Q23.3
ICD9CM 35 396.3 746.6
MeSH 44 D008944
SNOMED-CT 68 29928006 48724000

Summaries for Mitral Valve Insufficiency

MalaCards based summary : Mitral Valve Insufficiency, also known as mitral regurgitation, is related to mitral valve disease and orthostatic intolerance. An important gene associated with Mitral Valve Insufficiency is TBX5 (T-Box 5), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Human Embryonic Stem Cell Pluripotency. The drugs Ranolazine and Insulin Glargine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotype is cardiovascular system.

Related Diseases for Mitral Valve Insufficiency

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 mitral valve disease 32.6 ACE CRELD1 FBN1 NPPA
2 orthostatic intolerance 32.6 DCHS1 FBN1 PDLIM1
3 aortic valve insufficiency 30.9 ACE FBN1 NPPB
4 atrial fibrillation 30.9 ACE NPPA NPPB TBX5
5 acute myocardial infarction 30.8 ACE NPPA NPPB
6 inferior myocardial infarction 30.8 NPPB SULT1E1
7 tricuspid valve insufficiency 30.7 CRELD1 FBN1 NPPB PDZK1IP1
8 pulmonary edema 30.6 ACE NPPA NPPB
9 systolic heart failure 30.4 ACE NPPB
10 left bundle branch hemiblock 30.3 ACE NPPB SULT1E1
11 heart disease 30.3 ACE CRELD1 NPPA NPPB TBX5
12 diastolic heart failure 30.2 ACE NPPA NPPB
13 aortic coarctation 30.2 ACE FBN1
14 supravalvular aortic stenosis 30.2 FBN1 PDLIM1
15 central sleep apnea 30.1 NPPA NPPB
16 coronary artery anomaly 30.1 ACE NPPA NPPB
17 congestive heart failure 30.1 ACE NPPA NPPB
18 tetralogy of fallot 30.0 CRELD1 FBN1 NPPA NPPB TBX5
19 ischemic heart disease 30.0 ACE NPPB
20 anterolateral myocardial infarction 29.8 ACE NPPA NPPB SULT1E1
21 atrial heart septal defect 29.8 CRELD1 IL4I1 TBX5
22 mitral valve stenosis 29.8 CEP57 CRELD1 HCK NPPA NPPB
23 aortic valve disease 2 29.7 ACE GLS HCK NPPA NPPB PDLIM1
24 posterior myocardial infarction 29.7 IL4I1 SULT1E1
25 aortic valve disease 1 29.0 ACE CRELD1 FBN1 GLS HCK IL4I1
26 macrothrombocytopenia with mitral valve insufficiency 12.4
27 mitral valve prolapse 1 11.9
28 cardiospondylocarpofacial syndrome 11.6
29 mitral valve prolapse, familial, x-linked 11.6
30 ehlers-danlos syndrome, cardiac valvular type 11.2
31 mitral valve prolapse 2 11.2
32 dilated cardiomyopathy 10.6
33 cardiogenic shock 10.4
34 pulmonary hypertension 10.4
35 endocarditis 10.4
36 cleft mitral valve 10.3
37 congenital unguarded mitral orifice 10.3
38 mitral valve agenesis 10.3
39 infective endocarditis 10.3
40 hypertrophic cardiomyopathy 10.3
41 double-orifice mitral valve 10.3
42 marfan syndrome 10.2
43 rheumatic fever-related antigen 10.2
44 atrioventricular block 10.2
45 rheumatic fever 10.2
46 pulmonary valve disease 10.2 CRELD1 TBX5
47 hypoaldosteronism 10.2 ACE NPPA
48 vasculogenic impotence 10.2 ACE NPPA
49 ventricular septal defect 10.2
50 cor triatriatum 10.2

Graphical network of the top 20 diseases related to Mitral Valve Insufficiency:



Diseases related to Mitral Valve Insufficiency

Symptoms & Phenotypes for Mitral Valve Insufficiency

MGI Mouse Phenotypes related to Mitral Valve Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 ACE CRELD1 DCHS1 FBN1 HCK NPPA

Drugs & Therapeutics for Mitral Valve Insufficiency

Drugs for Mitral Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 852)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
2
Insulin Glargine Approved Phase 4,Phase 2 160337-95-1
3
Exenatide Approved, Investigational Phase 4,Phase 2,Not Applicable 141758-74-9 15991534
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113665-84-2, 120202-66-6 60606
7
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
8
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
9
Ranibizumab Approved Phase 4 347396-82-1 459903
10
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
11
Nadroparin Approved, Investigational Phase 4
12
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3 1197-18-8 5526
13
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
14 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
16
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
17
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
18
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
19
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19982-08-2 4054
20
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-23-7 5754
21
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
22
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-03-3
23
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 6740-88-1 3821
24
Ticlopidine Approved Phase 4,Phase 3,Phase 1 55142-85-3 5472
25
Cocaine Approved, Illicit Phase 4,Phase 1 50-36-2 5760 446220
26
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
27
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2 99-66-1 3121
28
Lithium carbonate Approved Phase 4,Phase 3,Phase 2,Not Applicable 554-13-2
29
Insulin Detemir Approved Phase 4,Not Applicable 169148-63-4 5311023
30
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
31
Minocycline Approved, Investigational Phase 4,Phase 1,Phase 2 10118-90-8 5281021
32
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 59467-70-8 4192
33
Dipyridamole Approved Phase 4,Phase 3,Not Applicable 58-32-2 3108
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
35
Iron Approved Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 7439-89-6 23925
36
Polyestradiol phosphate Approved Phase 4,Phase 3,Not Applicable 28014-46-2
37
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 50-28-2 5757
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 979-32-8
39
Riluzole Approved, Investigational Phase 4,Phase 1,Phase 2 1744-22-5 5070
40
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
41
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
42
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 137-58-6 3676
43
Infliximab Approved Phase 4,Phase 2,Not Applicable 170277-31-3
44
Nicotinamide Approved, Investigational Phase 4,Not Applicable 98-92-0 936
45
Metformin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 657-24-9 14219 4091
46
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable,Early Phase 1 56-12-2 119
47
Warfarin Approved Phase 4,Phase 1,Not Applicable 81-81-2 6691 54678486
48
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
49
Racepinephrine Approved Phase 4,Phase 3 329-65-7 838
50 Piracetam Approved, Investigational Phase 4,Not Applicable 7491-74-9

Interventional clinical trials:

(show top 50) (show all 1904)
# Name Status NCT ID Phase Drugs
1 Surgical Treatment of Ischemic Mitral Regurgitation Unknown status NCT01368575 Phase 4
2 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
3 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
4 ACTIV- Exercise Intervention in Healthy Young Men Unknown status NCT00401791 Phase 4
5 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
6 Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
7 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4 Lovaza group
8 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
9 The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke Unknown status NCT02452502 Phase 4
10 Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis Unknown status NCT01956409 Phase 4 18F-FCH;Magnevist
11 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
12 Integrated Positron Emission Tomography Magnetic Resonance (PET/MR) of Breast Cancer Unknown status NCT02766530 Phase 4
13 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
14 The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion Unknown status NCT02594995 Phase 4 NBP
15 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
16 Assess the Penumbra System in the Treatment of Acute Stroke Unknown status NCT01429350 Phase 4 intravenous (IV) recombinant human tissue plasminogen activator (rtPA)
17 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
18 Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
19 Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism Unknown status NCT02721888 Phase 4 Liraglutide;MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
20 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
21 Master Study for the Investigation of Safety and Efficacy of the SIELLO Pacemaker Leads Unknown status NCT00943046 Phase 4
22 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
23 Effectiveness and Safety of Yiqitongluo Granule for Stroke Unknown status NCT02604654 Phase 4 Yiqitongluo granule
24 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
25 A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population Unknown status NCT02618382 Phase 4 Tranexamic Acid
26 Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children Unknown status NCT01878994 Phase 4
27 Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea Unknown status NCT03053700 Phase 4 Bromonide 0.33% gel
28 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
29 German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET) Unknown status NCT01409330 Phase 4
30 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
31 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation Completed NCT02687932 Phase 4 LCZ696;Valsartan
32 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4 Candesartan;atacand;Placebo
33 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
34 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
35 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
36 Functional Effects of Botox on the Brain Using MRS and fMRI Completed NCT03373162 Phase 4 onabotulinumtoxinA
37 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
38 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed NCT00933608 Phase 4 memantine;Placebo
39 Evaluation Of HUK in Acute Stroke Patients: MRS and CTP Completed NCT03431909 Phase 4 Human urinary kallidinogenase (HUK);aspirin® , clopidogrel® , atorvastatin®
40 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
41 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
42 Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder Completed NCT00181883 Phase 4 quetiapine
43 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
44 Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease Completed NCT00551161 Phase 4 memantine
45 Biomarker Assessment of Glutamatergic Target Engagement Completed NCT02134951 Phase 4 Ketamine;Normal saline
46 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Completed NCT01372748 Phase 4
47 Argatroban for Preventing Occlusion and Restenosis After Extracranial Vertebral Artery Stenting Completed NCT01980316 Phase 4 Argatroban;non-argatroban treated group
48 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed NCT00826111 Phase 4 Eszopiclone;Placebo
49 Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting Completed NCT01163604 Phase 4 Argatroban;non-argatroban treated group
50 Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction Completed NCT02626494 Phase 4 N-Acetylcystein;Placebo

Search NIH Clinical Center for Mitral Valve Insufficiency

Cochrane evidence based reviews: mitral valve insufficiency

Genetic Tests for Mitral Valve Insufficiency

Genetic tests related to Mitral Valve Insufficiency:

# Genetic test Affiliating Genes
1 Mitral Regurgitation 29

Anatomical Context for Mitral Valve Insufficiency

MalaCards organs/tissues related to Mitral Valve Insufficiency:

41
Heart, Testes, Brain, Endothelial, Lung, Kidney, Bone

Publications for Mitral Valve Insufficiency

Articles related to Mitral Valve Insufficiency:

(show top 50) (show all 1389)
# Title Authors Year
1
Effect of Functional Mitral Regurgitation on Outcome in Patients Receiving Cardiac Resynchronization Therapy for Heart Failure. ( 30539749 )
2019
2
Mitral annulus enlargement in mitral regurgitation: Look to the north. ( 30017524 )
2019
3
The outcome of mitral regurgitation after the repair of anomalous left coronary artery from the pulmonary artery in infants and older children. ( 29528421 )
2018
4
Impact of Significant Mitral Regurgitation on Assessing the Severity of Aortic Stenosis. ( 29158019 )
2018
5
Prediction of the ischemic origin of functional mitral regurgitation in patients with systolic heart failure through posterior mitral leaflet angle. ( 29942334 )
2018
6
Torsion Mechanics as an Indicator of More Advanced Left Ventricular Systolic Dysfunction in Secondary Mitral Regurgitation in Patients with Dilated Cardiomyopathy: A 2D Speckle-Tracking Analysis. ( 29408823 )
2018
7
Two-year cardiac mortality after MitraClip treatment of functional mitral regurgitation in ischemic and non-ischemic dilated cardiomyopathy. ( 29929931 )
2018
8
A Very Rare Case of Cor Triatriatum with Severe Mitral Regurgitation. ( 29875858 )
2018
9
Effects of cardiac resynchronization therapy after inferior myocardial infarction on secondary mitral regurgitation and mitral valve geometry. ( 29222864 )
2018
10
The unique mechanism of functional mitral regurgitation in acute myocardial infarction: a prospective dynamic 4D quantitative echocardiographic study. ( 30517693 )
2018
11
A bad trade: Mitral regurgitation for mitral stenosis and atrial fibrillation. ( 30268568 )
2018
12
Acute severe mitral regurgitation with cardiogenic shock following balloon mitral valvuloplasty: echocardiographic findings and outcomes following surgery. ( 30414105 )
2018
13
Transseptal transcatheter mitral valve-in-valve for treatment of severe mitral regurgitation in failed bioprosthesis complicated with cardiogenic shock: Case report and review of the literature. ( 29636301 )
2018
14
Afterload mismatch after transcatheter mitral valve repair with MitraClip for degenerative mitral regurgitation in acute cardiogenic shock. ( 28303686 )
2018
15
Mitral valve repair for secondary mitral regurgitation in non-ischaemic dilated cardiomyopathy is associated with left ventricular reverse remodelling and increase of forward flow. ( 28329173 )
2018
16
Acute Mitral Regurgitation of Unknown Etiology Associated with Disseminated Intravascular Coagulation Eventually Diagnosed as Enterococcus Faecalis Infective Endocarditis by Mitral Valve Surgery. ( 30531674 )
2018
17
Congenital mitral regurgitation with Down syndrome. ( 29357688 )
2018
18
Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis. ( 30519962 )
2018
19
De novo mitral regurgitation as a cause of heart failure exacerbation in patients with hypertrophic cardiomyopathy. ( 29174016 )
2018
20
Repair Techniques for Mitral Valve Insufficiency in Children. ( 29425524 )
2018
21
Hemorrhagic Tamponade as Initial Manifestation of Systemic Lupus with Subsequent Refractory and Progressive Lupus Myocarditis Resulting in Cardiomyopathy and Mitral Regurgitation. ( 29610699 )
2018
22
Type A aortic dissection with pulmonary hypertension caused by pulmonary artery compression and acute mitral regurgitation. ( 30010878 )
2018
23
Does mitral valve repair matter in infants with ventricular septal defect combined with mitral regurgitation? ( 29049781 )
2018
24
Combined minimally invasive repair of the adult form of the scimitar syndrome and organic mitral regurgitation. ( 29415266 )
2018
25
Knowledge and application of European Society of Cardiology (ESC) Guidelines in the management of mitral regurgitation: this is not bad but we can do much better. ( 29659808 )
2018
26
Grading of mitral regurgitation in mitral valve prolapse using the average pixel intensity method. ( 29544951 )
2018
27
Aortic Dysfunction in Mitral Regurgitation Due to Floppy Mitral Valve/Mitral Valve Prolapse. ( 30208492 )
2018
28
Right-Sided Heart Structural and Functional Remodeling in Mitral Regurgitation Secondary to Mitral Valve Prolapse. ( 30293652 )
2018
29
Mitral Regurgitation and Heart Failure as the First Presentation in a Patient with Features of Two Connective Tissue Disorders: A Rare Combination of Mucopolysaccharidosis and Osteogenesis Imperfecta? ( 29225276 )
2018
30
Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease. ( 30402588 )
2018
31
Revisiting and Confirming the Prognostic Importance of Effective Regurgitant Orifice Area in Degenerative Mitral Regurgitation. ( 30354429 )
2018
32
Response by Penicka to Letter Regarding Article, "Prognostic Implications of Magnetic Resonance-Derived Quantification in Asymptomatic Patients With Organic Mitral Regurgitation: Comparison With Doppler Echocardiography-Derived Integrative Approach". ( 30354513 )
2018
33
Letter by Śpiewak Regarding Article, "Prognostic Implications of Magnetic Resonance-Derived Quantification in Asymptomatic Patients With Organic Mitral Regurgitation: Comparison With Doppler Echocardiography-Derived Integrative Approach". ( 30354515 )
2018
34
Exercise Stress Echocardiography in Degenerative Mitral Regurgitation. ( 30354671 )
2018
35
Exercise-Stress Echocardiography and Effort Intolerance in Asymptomatic/Minimally Symptomatic Patients With Degenerative Mitral Regurgitation Combined Invasive-Noninvasive Hemodynamic Monitoring. ( 30354676 )
2018
36
Arterial stiffness and mitral regurgitation in arterial hypertension: an intriguing pathophysiological link. ( 30359778 )
2018
37
Predictors of outcome in heart failure patients with severe functional mitral regurgitation undergoing MitraClip treatment. ( 30360995 )
2018
38
Effect of concomitant mitral valve procedures for severe mitral regurgitation during left ventricular assist device implantation. ( 30361785 )
2018
39
The evolving role of cardiac magnetic resonance in primary mitral regurgitation: ready for prime time? ( 30364971 )
2018
40
Prognostic value of exercise stress echocardiography in patients with secondary mitral regurgitation: a long-term follow-up study. ( 30374661 )
2018
41
Clipping within the leaflet - a novel approach to complex mitral regurgitation pathologies. ( 30375340 )
2018
42
Percutaneous mitral annuloplasty effectively corrected recurrent mitral regurgitation due to residual pseudo-cleft after MitraClip® implantation. ( 30376056 )
2018
43
Long-Term Results Following Repair for Degenerative Mitral Regurgitation - Analysis of Factors Influencing Durability. ( 30377076 )
2018
44
Echocardiography for ischemic mitral regurgitation: It is time to advance the imaging standards. ( 30385022 )
2018
45
Moderate ischemic mitral regurgitation: Which cases benefit most from isolated coronary artery bypass? ( 30391006 )
2018
46
Giant left atrial myxoma hiding severe preoperative mitral regurgitation. ( 30394520 )
2018
47
Degenerative Mitral Regurgitation After Non-Mitral Cardiac Surgery: MitraClip Versus Surgical Reconstruction. ( 30395854 )
2018
48
Impact of right heart function on outcome in patients with functional mitral regurgitation and chronic heart failure undergoing percutaneous edge-to-edge-repair. ( 30397932 )
2018
49
Imaging primary mitral regurgitation: the whole is better than the sum of its parts. ( 30418520 )
2018
50
Cleft mitral leaflets and severe mitral regurgitation: Testing the limits of percutaneous mitral valve repair. ( 30430718 )
2018

Variations for Mitral Valve Insufficiency

ClinVar genetic disease variations for Mitral Valve Insufficiency:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FBN1 NM_000138.4(FBN1): c.8016T> G (p.Cys2672Trp) single nucleotide variant Likely pathogenic rs1057518883 GRCh38 Chromosome 15, 48415571: 48415571
2 FBN1 NM_000138.4(FBN1): c.8016T> G (p.Cys2672Trp) single nucleotide variant Likely pathogenic rs1057518883 GRCh37 Chromosome 15, 48707768: 48707768
3 FBN1 NM_000138.4(FBN1): c.478T> C (p.Cys160Arg) single nucleotide variant Likely pathogenic rs1057518973 GRCh37 Chromosome 15, 48888540: 48888540
4 FBN1 NM_000138.4(FBN1): c.478T> C (p.Cys160Arg) single nucleotide variant Likely pathogenic rs1057518973 GRCh38 Chromosome 15, 48596343: 48596343
5 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh38 Chromosome 16, 15724166: 15724166
6 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh37 Chromosome 16, 15818023: 15818023
7 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 12, 114355868: 114355868
8 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 12, 114793673: 114793673

Expression for Mitral Valve Insufficiency

Search GEO for disease gene expression data for Mitral Valve Insufficiency.

Pathways for Mitral Valve Insufficiency

Pathways related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 NPPA NPPB PIK3R2
2
Show member pathways
11.37 NPPA NPPB PIK3R2 TBX5
3 10.5 NPPA NPPB
4 10.21 HCK PIK3R2

GO Terms for Mitral Valve Insufficiency

Biological processes related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.54 ACE DCHS1 FBN1
2 regulation of blood vessel size GO:0050880 9.4 NPPA NPPB
3 regulation of blood vessel diameter GO:0097746 9.32 ACE NPPB
4 endocardial cushion development GO:0003197 9.26 CRELD1 TBX5
5 cGMP biosynthetic process GO:0006182 9.16 NPPA NPPB
6 receptor guanylyl cyclase signaling pathway GO:0007168 8.96 NPPA NPPB
7 regulation of blood pressure GO:0008217 8.8 ACE NPPA NPPB

Molecular functions related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 FBN1 NPPA NPPB
2 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Mitral Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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