MCID: MTR002
MIFTS: 46

Mitral Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Insufficiency

MalaCards integrated aliases for Mitral Valve Insufficiency:

Name: Mitral Valve Insufficiency 12 44 15 73
Mitral Regurgitation 12 29 55 6
Congenital Insufficiency of Mitral Valve 12 73
Congenital Mitral Insufficiency 12
Congenital Mitral Regurgitation 12
Mitral Valve Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11502
ICD10 33 Q23.3
ICD9CM 35 396.3 746.6
MeSH 44 D008944

Summaries for Mitral Valve Insufficiency

MalaCards based summary : Mitral Valve Insufficiency, also known as mitral regurgitation, is related to mitral valve disease and orthostatic intolerance. An important gene associated with Mitral Valve Insufficiency is TBX5 (T-Box 5), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Human Embryonic Stem Cell Pluripotency. The drugs Ranolazine and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related phenotype is cardiovascular system.

Related Diseases for Mitral Valve Insufficiency

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 mitral valve disease 32.5 ACE CRELD1 FBN1 NPPA
2 orthostatic intolerance 32.0 DCHS1 FBN1 PDLIM1
3 congestive heart failure 30.4 ACE NPPA NPPB
4 mitral valve stenosis 28.6 CEP57 CRELD1 HCK NPPA NPPB SAMHD1
5 macrothrombocytopenia with mitral valve insufficiency 12.2
6 mitral valve prolapse 1 11.7
7 cardiospondylocarpofacial syndrome 11.5
8 mitral valve prolapse, familial, x-linked 11.1
9 ehlers-danlos syndrome, cardiac valvular type 11.1
10 mitral valve prolapse 2 11.1
11 central sleep apnea 10.8 NPPA NPPB
12 pulmonary valve disease 10.7 CRELD1 TBX5
13 hypoaldosteronism 10.7 ACE NPPA
14 renal artery disease 10.7 ACE NPPA
15 hypertension, diastolic 10.7 ACE NPPA
16 inferior myocardial infarction 10.7 NPPB SULT1E1
17 vasculogenic impotence 10.7 ACE NPPA
18 ebstein anomaly 10.7 CRELD1 NPPB
19 atrial septal defect 4 10.6 ACE TBX5
20 aortic coarctation 10.6 ACE FBN1
21 diastolic heart failure 10.5 ACE NPPB
22 tricuspid valve insufficiency 10.5 CRELD1 FBN1 NPPB
23 tricuspid valve disease 10.5 CRELD1 FBN1 NPPB
24 optic nerve sheath meningioma 10.5 ACE SAMHD1
25 syncope 10.5 NPPA NPPB
26 malignant hypertension 10.5 ACE NPPA
27 aortic valve insufficiency 10.5 ACE FBN1 NPPB
28 syndrome of inappropriate antidiuretic hormone 10.5 ACE NPPA NPPB
29 ischemic heart disease 10.5 ACE NPPB
30 idiopathic edema 10.5 ACE NPPA NPPB
31 acute myocardial infarction 10.4 ACE NPPA NPPB
32 malignant essential hypertension 10.4 ACE SAMHD1
33 chronic kidney failure 10.4 ACE NPPA NPPB
34 renal hypertension 10.3 ACE NPPB
35 atrial fibrillation 10.2 ACE NPPA NPPB TBX5
36 hepatorenal syndrome 10.2 ACE NPPA
37 cleft mitral valve 10.1
38 congenital unguarded mitral orifice 10.1
39 mitral valve agenesis 10.1
40 supravalvular aortic stenosis 10.0 FBN1 PDLIM1
41 tetralogy of fallot 10.0 CRELD1 FBN1 NPPA NPPB TBX5
42 aneurysm 10.0
43 systolic heart failure 10.0 ACE NPPB
44 anteroseptal myocardial infarction 9.9 EFS SULT1E1
45 hemolytic anemia 9.8
46 arteries, anomalies of 9.8
47 ventricular fibrillation, paroxysmal familial, 1 9.8
48 myocardial infarction 9.8
49 tendinitis 9.8
50 coronary artery anomaly 9.8

Graphical network of the top 20 diseases related to Mitral Valve Insufficiency:



Diseases related to Mitral Valve Insufficiency

Symptoms & Phenotypes for Mitral Valve Insufficiency

MGI Mouse Phenotypes related to Mitral Valve Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 NPPA PIK3R2 SULT1E1 TBX5 ACE CRELD1

Drugs & Therapeutics for Mitral Valve Insufficiency

Drugs for Mitral Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 826)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
2
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
3
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
4
Amlodipine Approved Phase 4 88150-42-9 2162
5
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
6
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
7
Valsartan Approved, Investigational Phase 4,Phase 1 137862-53-4 60846
8
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
9
Ranibizumab Approved Phase 4 347396-82-1 459903
10
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
11
Metformin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 657-24-9 14219 4091
12
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
13 Nadroparin Approved, Investigational Phase 4 9041-08-1
14
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
15
Menthol Approved Phase 4,Phase 2,Phase 3,Not Applicable 2216-51-5 16666
16
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
17
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
18
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
19
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19982-08-2 4054
20
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
21
Ticlopidine Approved Phase 4,Phase 3,Phase 1 55142-85-3 5472
22
Cocaine Approved, Illicit Phase 4,Phase 1 50-36-2 5760 446220
23
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
24
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2 99-66-1 3121
25
Insulin Detemir Approved Phase 4,Not Applicable 169148-63-4 5311023
26
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 23994
27
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
28
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 59467-70-8 4192
29
Dipyridamole Approved Phase 4,Phase 3,Not Applicable 58-32-2 3108
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
31
Iron Approved Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 7439-89-6 23925
32
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 216974-75-3
33
Riluzole Approved, Investigational Phase 4,Phase 1,Phase 2 1744-22-5 5070
34
Infliximab Approved Phase 4,Phase 2,Not Applicable 170277-31-3
35
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
36
Warfarin Approved Phase 4,Phase 1,Not Applicable 81-81-2 6691 54678486
37
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 137-58-6 3676
38
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
39
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
40 Piracetam Approved, Investigational Phase 4,Not Applicable 7491-74-9
41
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
42
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
43
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
44
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
45
Cosyntropin Approved Phase 4 16960-16-0 16129617
46
Etomidate Approved Phase 4,Not Applicable 33125-97-2 36339 667484
47
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-23-7 5754
48
Donepezil Approved Phase 4,Phase 3,Phase 2,Not Applicable 120014-06-4 3152
49
Galantamine Approved Phase 4 357-70-0 9651
50
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991

Interventional clinical trials:

(show top 50) (show all 1747)
# Name Status NCT ID Phase Drugs
1 Surgical Treatment of Ischemic Mitral Regurgitation Unknown status NCT01368575 Phase 4
2 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
3 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
4 ACTIV- Exercise Intervention in Healthy Young Men Unknown status NCT00401791 Phase 4
5 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4 Lovaza group
6 The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke Unknown status NCT02452502 Phase 4
7 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
8 Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis Unknown status NCT01956409 Phase 4 18F-FCH;Magnevist
9 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
10 The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion Unknown status NCT02594995 Phase 4 NBP
11 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
12 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
13 Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
14 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
15 Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism Unknown status NCT02721888 Phase 4 Liraglutide;MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
16 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
17 Master Study for the Investigation of Safety and Efficacy of the SIELLO Pacemaker Leads Unknown status NCT00943046 Phase 4
18 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
19 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
20 Effectiveness and Safety of Yiqitongluo Granule for Stroke Unknown status NCT02604654 Phase 4 Yiqitongluo granule
21 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
22 Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children Unknown status NCT01878994 Phase 4
23 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
24 German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET) Unknown status NCT01409330 Phase 4
25 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
26 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
27 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation Completed NCT02687932 Phase 4 LCZ696;Valsartan
28 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4 Candesartan;atacand;Placebo
29 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
30 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
31 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
32 Functional Effects of Botox on the Brain Using MRS and fMRI Completed NCT03373162 Phase 4 onabotulinumtoxinA
33 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
34 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed NCT00933608 Phase 4 memantine;Placebo
35 Evaluation Of HUK in Acute Stroke Patients: MRS and CTP Completed NCT03431909 Phase 4 Human urinary kallidinogenase (HUK);aspirin® , clopidogrel® , atorvastatin®
36 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
37 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
38 Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder Completed NCT00181883 Phase 4 quetiapine
39 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
40 Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease Completed NCT00551161 Phase 4 memantine
41 Biomarker Assessment of Glutamatergic Target Engagement Completed NCT02134951 Phase 4 Ketamine;Normal saline
42 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Completed NCT01372748 Phase 4
43 Argatroban for Preventing Occlusion and Restenosis After Extracranial Vertebral Artery Stenting Completed NCT01980316 Phase 4 Argatroban;non-argatroban treated group
44 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed NCT00826111 Phase 4 Eszopiclone;Placebo
45 Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting Completed NCT01163604 Phase 4 Argatroban;non-argatroban treated group
46 Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction Completed NCT02626494 Phase 4 N-Acetylcystein;Placebo
47 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
48 A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac) Completed NCT01449006 Phase 4 Maraviroc
49 Treating Climacteric Symptoms With a Complex Homeopathic Remedy Completed NCT00152776 Phase 4 ovaria comp 10 globuli 3 times per day 24 weeks
50 Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate Completed NCT00593112 Phase 4 OROS methylphenidate

Search NIH Clinical Center for Mitral Valve Insufficiency

Cochrane evidence based reviews: mitral valve insufficiency

Genetic Tests for Mitral Valve Insufficiency

Genetic tests related to Mitral Valve Insufficiency:

# Genetic test Affiliating Genes
1 Mitral Regurgitation 29

Anatomical Context for Mitral Valve Insufficiency

MalaCards organs/tissues related to Mitral Valve Insufficiency:

41
Brain, Heart, Liver, Testes, Prostate, Bone, Skeletal Muscle

Publications for Mitral Valve Insufficiency

Articles related to Mitral Valve Insufficiency:

(show top 50) (show all 52)
# Title Authors Year
1
Repair Techniques for Mitral Valve Insufficiency in Children. ( 29425524 )
2018
2
DOK7 congenital myasthenia may be associated with severe mitral valve insufficiency. ( 28716243 )
2017
3
Three Cases of Aneurysmatic Coronary Fistulas Associated With Mitral Valve Insufficiency. ( 28528052 )
2017
4
Inheritance Impacts Mitral Valve Insufficiency. ( 28993408 )
2017
5
Surgical Repair of Congenital Left Atrial Aneurysm and Mitral Valve Insufficiency in a Four-Year-Old Child. ( 27956709 )
2016
6
Cardiac remodelling and function with primary mitral valve insufficiency studied by magnetic resonance imaging. ( 26758406 )
2016
7
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency. ( 26733738 )
2016
8
Occurrence of mitral valve insufficiency in clinically healthy Beagle dogs. ( 26599093 )
2015
9
Review of mitral valve insufficiency: repair or replacement. ( 24672698 )
2014
10
Comparison of the novel Medtentia double helix mitral annuloplasty system with the Carpentier-Edwards Physio annuloplasty ring: morphological and functional long-term outcome in a mitral valve insufficiency sheep model. ( 23566678 )
2013
11
Clinical assessment of systolic myocardial deformations in dogs with chronic mitral valve insufficiency using two-dimensional speckle-tracking echocardiography. ( 23429036 )
2013
12
Evaluation of homocysteine levels in dogs with chronic mitral valve insufficiency. ( 22811561 )
2012
13
Surgical reconstruction techniques for mitral valve insufficiency from lesions with restricted leaflet motion in infants and children. ( 22169677 )
2012
14
High-grade mitral valve insufficiency after fracture of the Mitrofix prosthesis. ( 21982121 )
2011
15
Accessory left atrial chordae: an unusual cause of mitral valve insufficiency. ( 19660254 )
2010
16
Mitral valve growth after posterior annular stabilization with untreated autologous pericardial strip in children with mitral valve insufficiency. ( 20971267 )
2010
17
Diagnosis of acute mitral valve insufficiency using emergency bedside echocardiography. ( 19549012 )
2009
18
Severe mitral valve insufficiency after transcatheter atrial septal defect closure with the amplatzer septal occluder: a device-related complication. ( 20078713 )
2009
19
Ventricular fibrillation in acute mitral valve insufficiency caused by chordae tendineae rupture: report of a surgically corrected case. ( 19283885 )
2009
20
Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency. ( 19652480 )
2009
21
Mitral valve insufficiency: suspension of the posterior leaflet to the mitral annuloplasty ring. ( 18222224 )
2008
22
De novo 18q deletion with mitral valve insufficiency. ( 18990980 )
2008
23
Degenerative mitral valve insufficiency long term after heart transplantation: clinical and surgical considerations. ( 17484457 )
2007
24
Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency. ( 17916031 )
2007
25
Decreased systolic function and inadequate hypertrophy in large and small breed dogs with chronic mitral valve insufficiency. ( 17338151 )
2007
26
Mitral valve insufficiency and left ventricular remodeling in identical twins. ( 16733180 )
2006
27
Experimental stenting of the posterior mitral leaflet to correct prolapse in mitral valve insufficiency. ( 16112933 )
2005
28
Echocardiographic estimation of mean left atrial pressure in a canine model of acute mitral valve insufficiency. ( 15515583 )
2004
29
Effects of the ACE inhibitor quinapril on echocardiographic variables in horses with mitral valve insufficiency. ( 15109241 )
2003
30
Economic impact of mitral valve plasty versus replacement for mitral valve insufficiency. ( 12813377 )
2003
31
Very long-term results (more than 20 years) of valve repair with carpentier's techniques in nonrheumatic mitral valve insufficiency. ( 11568021 )
2001
32
Long-term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. ( 11568022 )
2001
33
Correlation between clinical and histologic patterns of degenerative mitral valve insufficiency: a histomorphometric study of 130 excised segments. ( 10724505 )
1999
34
Acute traumatic mitral valve insufficiency. ( 10421207 )
1999
35
Pulmonary sequestration presenting as mitral valve insufficiency. ( 9856886 )
1998
36
Reconstructive surgery in congenital mitral valve insufficiency (Carpentier's techniques): long-term results. ( 9451050 )
1998
37
Giant platelets with abnormal surface glycoproteins: a new familial disorder associated with mitral valve insufficiency. ( 9482416 )
1998
38
[Mitral valve insufficiency caused by tendinous cord rupture and mitral valve aneurysm. Significance of the echocardiographic study]. ( 9288984 )
1997
39
Effects of mild mitral valve insufficiency, sodium intake, and place of blood sampling on the renin-angiotensin system in dogs. ( 8659339 )
1996
40
Results of mitral valve reconstruction in mitral valve insufficiency. ( 7775539 )
1994
41
[Pre- and postoperative ventricular arrhythmia in mitral valve insufficiency]. ( 7848031 )
1994
42
Prevalence of mitral valve insufficiency in cavalier King Charles spaniels. ( 1595150 )
1992
43
In vitro balloon dilatation of mitral valve stenosis: the importance of subvalvar involvement as a cause of mitral valve insufficiency. ( 2039673 )
1991
44
Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. ( 2969307 )
1988
45
Increased mitral valve insufficiency during precordial whoop. ( 3383646 )
1988
46
Mitral valve insufficiency with congestive heart failure in a pukeko. ( 7451347 )
1980
47
Left ventricular angiocardiography in congenital mitral valve insufficiency of the dog. ( 1133066 )
1975
48
EKG of the month. Mitral valve insufficiency. ( 4756262 )
1973
49
Iatrogenic myocardial infarction and mitral valve insufficiency in a llama (Lama glama). ( 5014471 )
1972
50
Treatment of acute mitral valve insufficiency. ( 5269781 )
1970

Variations for Mitral Valve Insufficiency

ClinVar genetic disease variations for Mitral Valve Insufficiency:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;inv(14)(q24.1q32.1)dn inversion Uncertain significance
2 46;XY;inv(6)(p22q13)dn inversion Pathogenic
3 FBN1 NM_000138.4(FBN1): c.8016T> G (p.Cys2672Trp) single nucleotide variant Likely pathogenic rs1057518883 GRCh38 Chromosome 15, 48415571: 48415571
4 FBN1 NM_000138.4(FBN1): c.8016T> G (p.Cys2672Trp) single nucleotide variant Likely pathogenic rs1057518883 GRCh37 Chromosome 15, 48707768: 48707768
5 FBN1 NM_000138.4(FBN1): c.478T> C (p.Cys160Arg) single nucleotide variant Likely pathogenic rs1057518973 GRCh37 Chromosome 15, 48888540: 48888540
6 FBN1 NM_000138.4(FBN1): c.478T> C (p.Cys160Arg) single nucleotide variant Likely pathogenic rs1057518973 GRCh38 Chromosome 15, 48596343: 48596343
7 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh38 Chromosome 16, 15724166: 15724166
8 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh37 Chromosome 16, 15818023: 15818023
9 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 12, 114793673: 114793673
10 TBX5 NM_000192.3(TBX5): c.1221C> G (p.Tyr407Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 12, 114355868: 114355868

Expression for Mitral Valve Insufficiency

Search GEO for disease gene expression data for Mitral Valve Insufficiency.

Pathways for Mitral Valve Insufficiency

Pathways related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 NPPA NPPB PIK3R2
2
Show member pathways
11.37 NPPA NPPB PIK3R2 TBX5
3 10.5 NPPA NPPB
4 10.21 HCK PIK3R2

GO Terms for Mitral Valve Insufficiency

Biological processes related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.5 ACE DCHS1 FBN1
2 cGMP biosynthetic process GO:0006182 9.4 NPPA NPPB
3 regulation of blood vessel size GO:0050880 9.37 NPPA NPPB
4 regulation of blood vessel diameter GO:0097746 9.26 ACE NPPB
5 endocardial cushion development GO:0003197 9.16 CRELD1 TBX5
6 receptor guanylyl cyclase signaling pathway GO:0007168 8.96 NPPA NPPB
7 regulation of blood pressure GO:0008217 8.8 ACE NPPA NPPB

Molecular functions related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 FBN1 NPPA NPPB
2 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Mitral Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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