MCID: MTR083
MIFTS: 20

Mitral Valve Prolapse 3

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Mitral Valve Prolapse 3

MalaCards integrated aliases for Mitral Valve Prolapse 3:

Name: Mitral Valve Prolapse 3 57
Mitral Valve Prolapse, Myxomatous 3 57 13 73
Mitral Valve Prolapse, Myxomatous 3; Mmvp3 57
Myxomatous Mitral Valve Prolapse 3 57
Mmvp3 57
Mvp3 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
age-dependent penetrance


HPO:

32
mitral valve prolapse 3:
Onset and clinical course age-dependent penetrance
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 610840
MedGen 42 C1835814
UMLS 73 C1835814

Summaries for Mitral Valve Prolapse 3

OMIM : 57 Patients with mitral valve prolapse-3 (MVP3) have nonsyndromic MVP of variable severity with an autosomal dominant pattern of inheritance. For a general phenotypic description and discussion of genetic heterogeneity of mitral valve prolapse, see MVP1 (157700). (610840)

MalaCards based summary : Mitral Valve Prolapse 3, also known as mitral valve prolapse, myxomatous 3, is related to orthostatic intolerance. An important gene associated with Mitral Valve Prolapse 3 is MMVP3 (Mitral Valve Prolapse, Myxomatous 3). The drugs Cisplatin and Vinblastine have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotypes are mitral regurgitation and mitral valve prolapse

Related Diseases for Mitral Valve Prolapse 3

Diseases in the Mitral Valve Prolapse, Familial, Autosomal Dominant family:

Mitral Valve Prolapse 1 Mitral Valve Prolapse 2
Mitral Valve Prolapse 3

Diseases related to Mitral Valve Prolapse 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 10.9

Symptoms & Phenotypes for Mitral Valve Prolapse 3

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Heart:
mitral valve prolapse
mitral valve regurgitation


Clinical features from OMIM:

610840

Human phenotypes related to Mitral Valve Prolapse 3:

32
# Description HPO Frequency HPO Source Accession
1 mitral regurgitation 32 HP:0001653
2 mitral valve prolapse 32 HP:0001634

Drugs & Therapeutics for Mitral Valve Prolapse 3

Drugs for Mitral Valve Prolapse 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Vinblastine Approved Phase 3 865-21-4 13342 241903
3 Alkylating Agents Phase 3
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Antimitotic Agents Phase 3
7 Antineoplastic Agents, Phytogenic Phase 3
8 Mitomycins Phase 3
9 Nucleic Acid Synthesis Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Unknown status NCT00004209 Phase 3 cisplatin;mitomycin C;vinblastine sulfate

Search NIH Clinical Center for Mitral Valve Prolapse 3

Genetic Tests for Mitral Valve Prolapse 3

Anatomical Context for Mitral Valve Prolapse 3

MalaCards organs/tissues related to Mitral Valve Prolapse 3:

41
Lung

Publications for Mitral Valve Prolapse 3

Variations for Mitral Valve Prolapse 3

Expression for Mitral Valve Prolapse 3

Search GEO for disease gene expression data for Mitral Valve Prolapse 3.

Pathways for Mitral Valve Prolapse 3

GO Terms for Mitral Valve Prolapse 3

Sources for Mitral Valve Prolapse 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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