MVP3
MCID: MTR083
MIFTS: 20

Mitral Valve Prolapse 3 (MVP3)

Categories: Cardiovascular diseases, Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Mitral Valve Prolapse 3

MalaCards integrated aliases for Mitral Valve Prolapse 3:

Name: Mitral Valve Prolapse 3 58
Mitral Valve Prolapse, Myxomatous 3 58 13 74
Mitral Valve Prolapse, Myxomatous 3; Mmvp3 58
Myxomatous Mitral Valve Prolapse 3 58
Mmvp3 58
Mvp3 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
age-dependent penetrance


HPO:

33
mitral valve prolapse 3:
Onset and clinical course age-dependent penetrance
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 610840
MedGen 43 C1835814
UMLS 74 C1835814

Summaries for Mitral Valve Prolapse 3

OMIM : 58 Patients with mitral valve prolapse-3 (MVP3) have nonsyndromic MVP of variable severity with an autosomal dominant pattern of inheritance. For a general phenotypic description and discussion of genetic heterogeneity of mitral valve prolapse, see MVP1 (157700). (610840)

MalaCards based summary : Mitral Valve Prolapse 3, also known as mitral valve prolapse, myxomatous 3, is related to orthostatic intolerance and cone-rod dystrophy and hearing loss 2. An important gene associated with Mitral Valve Prolapse 3 is MMVP3 (Mitral Valve Prolapse, Myxomatous 3). The drugs Cisplatin and Vinblastine have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotypes are mitral valve prolapse and mitral regurgitation

Related Diseases for Mitral Valve Prolapse 3

Diseases in the Mitral Valve Prolapse, Familial, Autosomal Dominant family:

Mitral Valve Prolapse 1 Mitral Valve Prolapse 2
Mitral Valve Prolapse 3

Diseases related to Mitral Valve Prolapse 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 11.1
2 cone-rod dystrophy and hearing loss 2 11.1

Symptoms & Phenotypes for Mitral Valve Prolapse 3

Human phenotypes related to Mitral Valve Prolapse 3:

33
# Description HPO Frequency HPO Source Accession
1 mitral valve prolapse 33 HP:0001634
2 mitral regurgitation 33 HP:0001653

Symptoms via clinical synopsis from OMIM:

58
Cardiovascular Heart:
mitral valve prolapse
mitral valve regurgitation

Clinical features from OMIM:

610840

Drugs & Therapeutics for Mitral Valve Prolapse 3

Drugs for Mitral Valve Prolapse 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
Vinblastine Approved Phase 3 865-21-4 241903 13342
3 Antimitotic Agents Phase 3
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Antineoplastic Agents, Phytogenic Phase 3
7 Nucleic Acid Synthesis Inhibitors Phase 3
8 Alkylating Agents Phase 3
9 Mitomycins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Unknown status NCT00004209 Phase 3 cisplatin;mitomycin C;vinblastine sulfate

Search NIH Clinical Center for Mitral Valve Prolapse 3

Genetic Tests for Mitral Valve Prolapse 3

Anatomical Context for Mitral Valve Prolapse 3

MalaCards organs/tissues related to Mitral Valve Prolapse 3:

42
Lung

Publications for Mitral Valve Prolapse 3

Variations for Mitral Valve Prolapse 3

Expression for Mitral Valve Prolapse 3

Search GEO for disease gene expression data for Mitral Valve Prolapse 3.

Pathways for Mitral Valve Prolapse 3

GO Terms for Mitral Valve Prolapse 3

Sources for Mitral Valve Prolapse 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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