MCID: MTR003
MIFTS: 50

Mitral Valve Stenosis

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Stenosis

MalaCards integrated aliases for Mitral Valve Stenosis:

Name: Mitral Valve Stenosis 12 44 15 73
Mitral Stenosis 12 29 55 15
Rheumatic Mitral Stenosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1754
MeSH 44 D008946
NCIt 50 C50654
SNOMED-CT 68 79619009
ICD10 33 I05.0 I05.2

Summaries for Mitral Valve Stenosis

Disease Ontology : 12 A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.

MalaCards based summary : Mitral Valve Stenosis, also known as mitral stenosis, is related to patent ductus arteriosus 1 and tricuspid valve insufficiency. An important gene associated with Mitral Valve Stenosis is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and amb2 Integrin signaling. The drugs Dopamine and Dobutamine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and neutrophil, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 Mitral stenosis is a valvular heart disease characterized by the narrowing of the orifice of the mitral... more...

Related Diseases for Mitral Valve Stenosis

Diseases related to Mitral Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 patent ductus arteriosus 1 30.4 CRELD1 NPPB
2 tricuspid valve insufficiency 30.3 ACVRL1 CRELD1 NPPB
3 pulmonary hypertension 30.2 ACVRL1 NPPA NPPB
4 mitral valve insufficiency 30.1 CEP57 CRELD1 HCK NPPA NPPB
5 pericardial effusion 30.0 NPPA NPPB
6 pulmonary hypertension, primary, 1 30.0 ACVRL1 NPPA NPPB
7 cardiac tamponade 30.0 ACVRL1 NPPB
8 syncope 29.9 NPPA NPPB
9 tricuspid valve stenosis 29.9 BUB1B CRELD1
10 aortic valve disease 1 29.9 CRELD1 HCK NPPB
11 acute myocardial infarction 29.8 NPPA NPPB SELP SERPINC1
12 aortic valve disease 2 29.7 HCK NPPA NPPB
13 thrombosis 29.7 PF4 SELP SERPINC1
14 arteries, anomalies of 29.7 ACVRL1 NPPB SELP SERPINC1
15 tetralogy of fallot 29.7 CRELD1 NPPA NPPB
16 coronary artery anomaly 29.6 NPPA NPPB PF4 SELP
17 anomalous left coronary artery from the pulmonary artery 29.5 CRELD1 PF4
18 atrial fibrillation 29.5 NPPA NPPB PF4 PPBP SELP
19 myocardial infarction 29.5 NPPA NPPB PF4 PPBP SELP SERPINC1
20 vascular disease 29.3 ACVRL1 PPBP SELP SERPINC1
21 thrombophilia due to activated protein c resistance 29.2 PF4 SERPINC1
22 heart disease 29.2 CRELD1 NPPA NPPB PF4 PPBP SELP
23 congenital mitral stenosis 12.5
24 mitral atresia 10.7
25 cor triatriatum 10.3
26 lutembacher's syndrome 10.3
27 hemosiderosis 10.3
28 hypoplasia of the mitral valve annulus 10.2
29 congenital supravalvular mitral ring 10.2
30 anterolateral myocardial infarction 10.2 NPPA NPPB
31 central sleep apnea 10.2 NPPA NPPB
32 wolff-parkinson-white syndrome 10.2
33 dextrocardia 10.2
34 syndrome of inappropriate antidiuretic hormone 10.2 NPPA NPPB
35 hyperhidrosis, gustatory 10.2 ATP2A2 HCK
36 idiopathic edema 10.2 NPPA NPPB
37 korean hemorrhagic fever 10.2 NPPA SERPINC1
38 diastolic heart failure 10.2 NPPA NPPB
39 systemic lupus erythematosus 10.2
40 lupus erythematosus 10.2
41 retinal vascular occlusion 10.2 SELP SERPINC1
42 atrial heart septal defect 10.1
43 legg-calve-perthes disease 10.1 SELP SERPINC1
44 intermediate coronary syndrome 10.1 SELP SERPINC1
45 portal vein thrombosis 10.1 SELP SERPINC1
46 angina pectoris 10.1 NPPB SERPINC1
47 mosaic variegated aneuploidy syndrome 1 10.1 BUB1B CEP57
48 mosaic variegated aneuploidy syndrome 10.1 BUB1B CEP57
49 hypoplastic left heart syndrome 1 10.1
50 hypoplastic left heart syndrome 10.1

Comorbidity relations with Mitral Valve Stenosis via Phenotypic Disease Network (PDN): (show all 19)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypothyroidism
Intermediate Coronary Syndrome Intracranial Embolism
Ischemic Heart Disease Mitral Valve Disease
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatic Heart Disease Rheumatic Myocarditis
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Mitral Valve Stenosis:



Diseases related to Mitral Valve Stenosis

Symptoms & Phenotypes for Mitral Valve Stenosis

GenomeRNAi Phenotypes related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 ACVRL1 BUB1B HCK
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 BUB1B
3 Decreased substrate adherent cell growth GR00193-A-4 9.35 ACVRL1
4 Paclitaxel antagonistic effect GR00113-A-0 8.62 BUB1B HCK

MGI Mouse Phenotypes related to Mitral Valve Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACVRL1 ATP2A2 BUB1B CRELD1 HCK NPPA
2 hematopoietic system MP:0005397 9.56 ACVRL1 ATP2A2 BUB1B HCK NPPA PF4
3 renal/urinary system MP:0005367 9.02 ACVRL1 ATP2A2 NPPA SELP SERPINC1

Drugs & Therapeutics for Mitral Valve Stenosis

Drugs for Mitral Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Dobutamine Approved Phase 4 34368-04-2 36811
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Norepinephrine Approved Phase 4 51-41-2 439260
6
Warfarin Approved Phase 4 81-81-2 6691 54678486
7
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
8 Simendan Investigational Phase 4 131741-08-7
9
protease inhibitors Phase 4
10 Anticoagulants Phase 4
11 Serine Proteinase Inhibitors Phase 4
12 Antithrombin III Phase 4
13 HIV Protease Inhibitors Phase 4
14 Antithrombins Phase 4
15 Vasodilator Agents Phase 4
16 Dopamine Agents Phase 4
17 Adrenergic beta-Agonists Phase 4
18 Sympathomimetics Phase 4
19 Anti-Arrhythmia Agents Phase 4,Phase 3
20 Adrenergic Agents Phase 4,Phase 3
21 Epinephryl borate Phase 4
22 Adrenergic Agonists Phase 4
23 Neurotransmitter Agents Phase 4,Phase 3
24 Autonomic Agents Phase 4,Phase 3
25 Peripheral Nervous System Agents Phase 4,Phase 3
26 Cardiotonic Agents Phase 4
27 Protective Agents Phase 4
28 Phosphodiesterase Inhibitors Phase 4
29 Calamus Phase 4
30 Dabigatran Phase 4
31
Atenolol Approved Phase 3 29122-68-7 2249
32 Antihypertensive Agents Phase 3,Phase 1,Phase 2
33 Sympatholytics Phase 3
34 Adrenergic Antagonists Phase 3
35 Adrenergic beta-Antagonists Phase 3
36 Adrenergic beta-1 Receptor Antagonists Phase 3
37
Bosentan Approved, Investigational Phase 1, Phase 2 147536-97-8 104865
38 Endothelin Receptor Antagonists Phase 1, Phase 2
39
Cabergoline Approved 81409-90-7 54746
40
Levodopa Approved 59-92-7 6047
41
Sevoflurane Approved, Vet_approved 28523-86-6 5206
42 Dopamine agonists
43 Anesthetics, Inhalation
44 Central Nervous System Depressants
45 Platelet Aggregation Inhibitors
46 Anesthetics
47 Anesthetics, General
48 Liver Extracts

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
2 The Effects of Levosimendan During Mitral Valve Surgery Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
3 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
4 Dabigatran in Patients With Atrial Fibrillation and Mitral Biological Prostheses Enrolling by invitation NCT03183843 Phase 4 Dabigatran Etexilate;Warfarin
5 Efficacy and Safety of Rivaroxiban Compare With Vitamin K Antagonist Warfarin Withdrawn NCT03673605 Phase 4 Rivaroxaban 15 mg;Warfarin
6 Effect of Ivabradine on Heart Rate & Effort Tolerance in Mitral Stenosis in Sinus Rhythm Completed NCT01022463 Phase 3 Ivabradine;Atenolol
7 Bosentan for Severe Mitral Valve Dysfunction Unknown status NCT01270750 Phase 1, Phase 2 BOSENTAN
8 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
9 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed NCT00209339 Phase 1, Phase 2
10 Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Recruiting NCT02830204 Phase 1, Phase 2
11 NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation Active, not recruiting NCT03015194 Phase 2
12 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery Unknown status NCT02374229 Phase 1
13 Mitral Implantation of TRAnscatheter vaLves Active, not recruiting NCT02370511 Phase 1
14 Mitral Valve Area Assessment: Comparison With Transthoracic Echocardiography and Magnetic Resonance Imaging Unknown status NCT00654472
15 Non-invasive Characterization of the Mechanisms of Atrial Fibrillation Maintenance Unknown status NCT02497248
16 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
17 Mitral Valve Area Using 3-dimensional Transesophageal Echocardiography Completed NCT01694251
18 Balloon Valvuloplasty Registry Completed NCT00005199
19 Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery Completed NCT02831270 hydroxyethyl starch (HES 130/0.6)
20 Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery Completed NCT02502448 Not Applicable hydroxyethyl starch (HES 130/0.6)
21 Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra Completed NCT00636987 Not Applicable
22 Teledi@Log - Tele-rehabilitation of Heart Patients Completed NCT01752192 Not Applicable
23 Logical Analysis of Data and Cardiac Surgery Risk Completed NCT00081666
24 ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies (RAMSES) Completed NCT02344901
25 EVEREST II Pivotal Study High Risk Registry (HRR) Completed NCT01940120 Not Applicable
26 Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study Completed NCT02375282 Not Applicable
27 Pivotal Study of a Percutaneous Mitral Valve Repair System Completed NCT00209274 Not Applicable
28 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
29 Real World Expanded Multicenter Study of the MitraClip® System (REALISM) Completed NCT01931956 Not Applicable
30 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
31 Assessment of Adherence to New Oral anTicoagulants in Atrial Fibrillation patiEnts Within the Outpatient registrY Completed NCT03790917
32 ACCESS-Europe A Two-Phase Observational Study of the MitraClip® System in Europe Completed NCT01288976 Medical Management
33 French National Observatory of Percutaneous Mitral Commissurotomy Recruiting NCT02783248
34 The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2 Recruiting NCT02552771 Not Applicable
35 Annular Reshaping of the Mitral Valve for MR Using the Millipede IRIS System Recruiting NCT02607527 Not Applicable
36 Determine the Effective Dose 95 of Sevoflurane in Adult Patients Recruiting NCT02711384
37 Phono- and Electrocardiogram Assisted Detection of Valvular Disease Recruiting NCT03458806
38 Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery Recruiting NCT02925819
39 Neurologic Outcome After Mitral Valve Surgery Recruiting NCT03798015
40 Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) Recruiting NCT01626079 Not Applicable
41 HighLife™ Transcatheter Mitral Valve Replacement System Study Recruiting NCT02974881 Not Applicable
42 AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System Recruiting NCT03339115 Not Applicable
43 Concordance Between Echocardiographic Assessment Performed in the Initial Phase of Decompensated Cirrhosis With Edema and Ascites by an Expert Intensive Care Physician and a Non-expert Gastroenterologist Recruiting NCT03650660
44 Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral Stenosis Active, not recruiting NCT01406353 Not Applicable
45 Post-Approval Study for the MOSAIC® Bioprostheses Active, not recruiting NCT01574625
46 AVJ-514 Japan Trial Active, not recruiting NCT02520310 Not Applicable
47 ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE) Active, not recruiting NCT01757665 Not Applicable
48 Study to Develop a Tool to Estimate the Kidney Function in Databases Without Laboratory Data Active, not recruiting NCT03605810
49 Silent Atrial Fibrillation in Patients With Mitral Stenosis and Sinus Rhythm and Its Correlation Left Atrial Thrombus Not yet recruiting NCT03505073
50 Mitral Annuloplasty Rings RCT Not yet recruiting NCT03290872 Not Applicable

Search NIH Clinical Center for Mitral Valve Stenosis

Cochrane evidence based reviews: mitral valve stenosis

Genetic Tests for Mitral Valve Stenosis

Genetic tests related to Mitral Valve Stenosis:

# Genetic test Affiliating Genes
1 Mitral Stenosis 29

Anatomical Context for Mitral Valve Stenosis

MalaCards organs/tissues related to Mitral Valve Stenosis:

41
Heart, Bone, Neutrophil, Lung, Monocytes, Thyroid, Bone Marrow

Publications for Mitral Valve Stenosis

Articles related to Mitral Valve Stenosis:

(show top 50) (show all 1047)
# Title Authors Year
1
Degenerative Mitral Stenosis: From Pathophysiology to Challenging Interventional Treatment. ( 29731112 )
2019
2
Mitral Valve Stenosis: Still a Clinical Challenge? ( 29772580 )
2018
3
Repair for Congenital Mitral Valve Stenosis. ( 29425525 )
2018
4
A bad trade: Mitral regurgitation for mitral stenosis and atrial fibrillation. ( 30268568 )
2018
5
Comparative study on maternal and fetal outcome in pregnant women with rheumatic heart disease and severe mitral stenosis undergoing percutaneous balloon mitral valvotomy before or during pregnancy. ( 30392507 )
2018
6
Myectomy and Left Atrial-to-Left Ventricular Conduit for Severe Calcific Mitral Stenosis and Hypertrophic Cardiomyopathy. ( 29496436 )
2018
7
Gluteal Leiomyosarcoma: A Rare Cause of Severe Mitral Stenosis. ( 29456048 )
2018
8
Functional Mitral Stenosis: Imposture of Primary Cardiac Intimal Sarcoma. ( 30344829 )
2018
9
Rheumatic Mitral Stenosis with Incidental Wolff-Parkinson-White Syndrome: A Rare Association. Treated by Percutaneous Transmitral Commissurotomy and Radiofrequency Ablation. ( 30505396 )
2018
10
The impact of mitral stenosis on outcomes of aortic valve stenosis patient undergoing surgical aortic valve replacement or transcatheter aortic valve replacement. ( 29774601 )
2018
11
Fatal heart failure caused by severe pulmonary regurgitation, tricuspid regurgitation and late-onset mitral stenosis in an adult patient with Noonan syndrome: a case report. ( 30012103 )
2018
12
Severe Aortic and Mitral Stenosis Secondary to Slowly Progressive Hunter Syndrome in an Elderly Patient. ( 28931788 )
2018
13
Rare Combination of Pathologies Causing Mitral Stenosis and Mitral Regurgitation: A Case Report. ( 29334829 )
2018
14
Predicting functional mitral stenosis after restrictive annuloplasty for ischemic mitral regurgitation. ( 29512090 )
2018
15
Pulmonary arterial pressure detects functional mitral stenosis after annuloplasty for primary mitral regurgitation: An exercise stress echocardiographic study. ( 29114917 )
2018
16
Impact of 3D echocardiography on grading of mitral stenosis and prediction of clinical events ( 30303687 )
2018
17
Severe mitral stenosis secondary to eosinophilic granulomatosis resolving after pharmacological treatment. ( 30338566 )
2018
18
Melody valve in mitral position: Complete fracture causing acute mitral stenosis in a child. ( 30380204 )
2018
19
Severe Prosthetic Mitral Stenosis Misinterpreted as Severe Aortic Regurgitation. ( 30442518 )
2018
20
Quantification of rheumatic mitral stenosis severity with three-dimensional vena contracta area. ( 30548321 )
2018
21
Association between late gadolinium enhancement and global longitudinal strain in patients with rheumatic mitral stenosis. ( 30556113 )
2018
22
Adult Case of Parachute-Like Asymmetrical Mitral Valve Complicated by Mitral Stenosis and Thrombus Formation. ( 28804106 )
2018
23
Development and Validation of a Teaching Module for Echocardiographic Scoring of Rheumatic Mitral Stenosis. ( 28867640 )
2018
24
Direct transatrial implantation of balloon-expandable valve for mitral stenosis with severe annular calcifications: early experience and lessons learned. ( 28950331 )
2018
25
Relation of an Echocardiographic-Based Cardiac Calcium Score to Mitral Stenosis Severity and Coronary Artery Disease in Patients with Severe Aortic Stenosis. ( 29198984 )
2018
26
Different indicators for postprocedural mitral stenosis caused by single- or multiple-clip implantation after percutaneous mitral valve repair. ( 29208340 )
2018
27
Atrial deformation correlated with functional capacity in mitral stenosis patients. ( 29226357 )
2018
28
A novel method to measure mitral valve area in patients with rheumatic mitral stenosis using three-dimensional transesophageal echocardiography: Feasibility and validation. ( 29271495 )
2018
29
Severe Mitral Stenosis and Persistent Left Appendage Thrombosis: When an Old Percutaneous Solution Meets New Percutaneous Strategies. ( 29289633 )
2018
30
Saphenous vein graft aneurysm and fistula with compression mimicking mitral stenosis. ( 29301810 )
2018
31
When the gold standard is not always golden: The value of invasive hemodynamic assessment to overcome the pitfalls of echocardiography in challenging cases of mitral stenosis. ( 29342329 )
2018
32
Mitral leaflet separation to evaluate the severity of mitral stenosis: Validation of the index by transesophageal three-dimensional echocardiography. ( 29356070 )
2018
33
Predictors of Long-Term Outcomes of Percutaneous Mitral Valvuloplasty in Patients with Rheumatic Mitral Stenosis. ( 29436196 )
2018
34
Management of atrial fibrillation in patients with rheumatic mitral stenosis. ( 29453328 )
2018
35
Functional mitral stenosis after mitral valve repair for Type II dysfunction: determinants and impacts on long-term outcome. ( 29490023 )
2018
36
Fine versus coarse atrial fibrillation in rheumatic mitral stenosis: The impact of aging and the clinical significance. ( 29504703 )
2018
37
Outcomes following balloon mitral valvuloplasty in pregnant females with mitral stenosis and significant sub valve disease with severe decompensated heart failure. ( 29527717 )
2018
38
Prevalence and Outcomes of Mitral Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement: Findings From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry. ( 29622149 )
2018
39
Acute Right Ventricular Failure Postintubation in a Mitral Stenosis Patient. ( 29629260 )
2018
40
Different Characteristics, Clinical Outcomes, and Left Atrial Reverse Remodeling in Patients with Mitral Stenosis Maintaining Sinus Rhythm for at Least 10 Years after Successful Percutaneous Mitral Valvuloplasty. ( 29649813 )
2018
41
Left Circumflex Artery Rupture with Left Atrial Tamponade and Functional Mitral Stenosis. ( 29670772 )
2018
42
Evaluation of serum 25-hydroxyvitamin D levels in calcific rheumatic mitral stenosis- A cross sectional study. ( 29716696 )
2018
43
Effect of percutaneous transvenous mitral commissurotomy on brain natriuretic peptide in mitral stenosis in tertiary care hospitals of Peshawar. ( 29885182 )
2018
44
The correlation between conventional echocardiography and two-dimensional speckle strain imaging for evaluating left atrial function in patients with moderate to severe mitral stenosis. ( 29971826 )
2018
45
Three-dimensional transesophageal echocardiography vs cardiac magnetic resonance in the assessment of planimetric mitral valve area in rheumatic mitral stenosis. ( 29981197 )
2018
46
Left atrial compliance: an overlooked predictor of clinical outcome in patients with mitral stenosis or atrial fibrillation undergoing invasive management. ( 30008763 )
2018
47
Immediate impact of percutaneous transvenous mitral commisurotomy on right ventricle longitudinal strain in patients of mitral stenosis. ( 30011352 )
2018
48
Severe Mitral Stenosis. ( 30021094 )
2018
49
Ivabradine Versus Beta-Blockers in Mitral Stenosis in Sinus Rhythm: An Updated Meta-Analysis of Randomized Controlled Trials. ( 30116450 )
2018
50
Impact of 3D echocardiography on grading of mitral stenosis and prediction of clinical events. ( 30139798 )
2018

Variations for Mitral Valve Stenosis

Expression for Mitral Valve Stenosis

Search GEO for disease gene expression data for Mitral Valve Stenosis.

Pathways for Mitral Valve Stenosis

Pathways related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 ATP2A2 PF4 PPBP SELP SERPINC1
2 10.94 HCK SELP
3 10.37 HCK SERPINC1
4 9.97 NPPA NPPB

GO Terms for Mitral Valve Stenosis

Cellular components related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 NPPA NPPB PF4 PPBP SELP SERPINC1
2 collagen-containing extracellular matrix GO:0062023 8.92 CRELD1 NPPA PF4 SERPINC1

Biological processes related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.76 NPPA NPPB PF4 PPBP
2 platelet degranulation GO:0002576 9.58 PF4 PPBP SELP
3 inflammatory response GO:0006954 9.56 HCK PF4 PPBP SELP
4 negative regulation of cell growth GO:0030308 9.54 ACVRL1 NPPA NPPB
5 regulation of cardiac conduction GO:1903779 9.51 ATP2A2 NPPA
6 leukocyte chemotaxis GO:0030595 9.49 PF4 PPBP
7 positive regulation of heart rate GO:0010460 9.48 ATP2A2 NPPA
8 regulation of blood vessel size GO:0050880 9.43 NPPA NPPB
9 cardiac muscle hypertrophy in response to stress GO:0014898 9.32 ATP2A2 NPPA
10 cGMP biosynthetic process GO:0006182 9.16 NPPA NPPB
11 receptor guanylyl cyclase signaling pathway GO:0007168 8.96 NPPA NPPB
12 regulation of blood pressure GO:0008217 8.8 ACVRL1 NPPA NPPB

Molecular functions related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 ACVRL1 ATP2A2 BUB1B CEP57 HCK NPPA
2 heparin binding GO:0008201 9.13 PF4 SELP SERPINC1
3 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Mitral Valve Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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