Mitral Valve Stenosis

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Mitral Valve Stenosis

MalaCards integrated aliases for Mitral Valve Stenosis:

Name: Mitral Valve Stenosis 12 44 15 17 70
Mitral Stenosis 12 29 54 6 15 32
Rheumatic Mitral Stenosis 70


External Ids:

Disease Ontology 12 DOID:1754
MeSH 44 D008946
NCIt 50 C50654
SNOMED-CT 67 79619009
ICD10 32 I05.0 I05.2
UMLS 70 C0026269 C0264766

Summaries for Mitral Valve Stenosis

Disease Ontology : 12 A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.

MalaCards based summary : Mitral Valve Stenosis, also known as mitral stenosis, is related to mitral valve insufficiency and infective endocarditis. An important gene associated with Mitral Valve Stenosis is ATP2A2 (ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Dopamine and Dobutamine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Mitral stenosis is a valvular heart disease characterized by the narrowing of the orifice of the mitral... more...

Related Diseases for Mitral Valve Stenosis

Diseases in the Mitral Valve Stenosis family:

Congenital Mitral Valve Insufficiency and/or Stenosis

Diseases related to Mitral Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 630)
# Related Disease Score Top Affiliating Genes
1 mitral valve insufficiency 30.9 REN NPPB NPPA F2 CRP ACE
2 infective endocarditis 30.8 PPBP PF4 F2 CRP
3 endocarditis 30.7 SERPINC1 PPBP PF4 F2 CRP
4 constrictive pericarditis 30.6 REN NPPB CRP ACE
5 heparin-induced thrombocytopenia 30.5 SERPINC1 PF4 F3
6 discrete subaortic stenosis 30.4 NPPA F3
7 patent ductus arteriosus 1 30.4 REN NPPB MIR379 CRP ACE
8 pulmonary disease, chronic obstructive 30.4 SERPINA3 NPPB CRP ACE
9 pericarditis 30.4 NPPB CRP ACE
10 orthostatic intolerance 30.4 REN MIR379 ACE
11 pulmonary valve insufficiency 30.4 REN NPPB CRP ACE
12 acute kidney failure 30.4 REN NPPA F2
13 varicose veins 30.3 VWF SERPINC1 F2
14 congestive heart failure 30.3 REN NPPB NPPA CRP ACE
15 hypertrophic cardiomyopathy 30.2 VWF REN NPPB NPPA ATP2A2 ACE
16 mediastinitis 30.1 F3 F2 CRP
17 amyloidosis 30.1 SERPINA3 NPPB FGA CRP
18 ischemia 30.1 SELP PLG NPPB ACE
19 angina pectoris 30.1 NPPB F3 CRP ACE
20 toxic shock syndrome 30.0 SERPINC1 F3 CRP
21 end stage renal disease 30.0 REN NPPB CRP ACE
22 rheumatic myocarditis 30.0 MIR379 CRP
23 pulmonary edema 30.0 SERPINC1 REN NPPB NPPA F2 CRP
24 aortic disease 30.0 SERPINA3 REN CRP ACE
25 systolic heart failure 29.9 NPPB NPPA CRP ACE
26 hypertensive heart disease 29.9 REN NPPB NPPA ACE
27 hemopericardium 29.9 PLG F3 F2 CRP
28 tricuspid valve insufficiency 29.9 REN NPPB F3 F2 CRP ACE
29 arteriosclerosis 29.9 SERPINC1 SELP F3 CRP ACE
30 inferior myocardial infarction 29.8 PLG NPPB ACE
31 sleep apnea 29.8 REN NPPB CRP ACE
32 factor xii deficiency 29.8 VWF SERPINC1 F3
33 lung disease 29.8 SERPINA3 NPPB F3 CRP ACE
34 sleep disorder 29.8 REN CRP ACE
35 syphilis 29.8 SERPINA3 F2 CRP ACE
36 eclampsia 29.8 SERPINC1 REN F2 ACE
37 coronary stenosis 29.8 VWF NPPB CRP ACE
38 exanthem 29.7 F3 F2 CRP ACE
39 arteries, anomalies of 29.7 SERPINA3 REN PLG F3 CRP ACE
40 familial hypercholesterolemia 29.7 NPPA F2 CRP ACE
41 mitral valve disease 29.7 SERPINA3 REN NPPB NPPA MIR1306 F3
42 cardiac tamponade 29.7 REN PLG NPPB F3 F2 CRP
43 anuria 29.7 REN F3 F2 CRP ACE
44 aortic valve insufficiency 29.7 VWF REN NPPB NPPA F3 F2
45 hepatic veno-occlusive disease 29.6 SERPINC1 PLG F3
46 sickle cell anemia 29.6 VWF F2 CRP ACE
47 pericardial effusion 29.6 REN NPPB NPPA F3 F2 CRP
48 tetralogy of fallot 29.5 REN NPPB NPPA MIR379 CRP ACE
49 inherited metabolic disorder 29.5 SERPINA3 REN F2 CRP ACE
50 aspiration pneumonia 29.5 SERPINA3 F3 F2 CRP ACE

Comorbidity relations with Mitral Valve Stenosis via Phenotypic Disease Network (PDN): (show all 17)

Acute Cystitis Aortic Valve Disease 1
Bronchitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Mitral Valve Disease
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatic Heart Disease Rheumatic Myocarditis
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Mitral Valve Stenosis:

Diseases related to Mitral Valve Stenosis

Symptoms & Phenotypes for Mitral Valve Stenosis

MGI Mouse Phenotypes related to Mitral Valve Stenosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ACE ATP2A2 CRP F2 F3 FGA
2 homeostasis/metabolism MP:0005376 9.47 ACE ATP2A2 CRP F2 F3 FGA

Drugs & Therapeutics for Mitral Valve Stenosis

Drugs for Mitral Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Dobutamine Approved Phase 4 34368-04-2 36811
Norepinephrine Approved Phase 4 51-41-2 439260
Simendan Investigational Phase 4 131741-08-7
Dabigatran Investigational Phase 4 211914-51-1
6 Neurotransmitter Agents Phase 4
7 Adrenergic Agents Phase 4
8 Calamus Phase 4
9 Adrenergic Agonists Phase 4
10 Vasodilator Agents Phase 4
11 Cardiotonic Agents Phase 4
12 Adrenergic beta-Agonists Phase 4
13 Sympathomimetics Phase 4
14 Phosphodiesterase 3 Inhibitors Phase 4
15 Phosphodiesterase Inhibitors Phase 4
16 Protective Agents Phase 4
Atenolol Approved Phase 3 29122-68-7 2249
Thrombin Approved, Investigational Phase 3
Protein C Approved Phase 3
Ramipril Approved Phase 3 87333-19-5 5362129
21 Anti-Arrhythmia Agents Phase 3
22 Adrenergic Antagonists Phase 3
23 Adrenergic beta-Antagonists Phase 3
24 Sympatholytics Phase 3
25 Adrenergic beta-1 Receptor Antagonists Phase 3
26 Antidotes Phase 3
27 Vitamin K 1 Phase 3
28 protein S Phase 3
29 Antihypertensive Agents Phase 3
30 Angiotensin-Converting Enzyme Inhibitors Phase 3
Bosentan Approved, Investigational Phase 1, Phase 2 147536-97-8 104865
32 Endothelin Receptor Antagonists Phase 1, Phase 2
33 Antibiotics, Antitubercular
34 Anti-Bacterial Agents
35 Nutrients
36 Micronutrients
37 Trace Elements
38 Vitamin MK 7
39 Coagulants
40 Antifibrinolytic Agents
41 Vitamin K 2
42 Hemostatics

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 The Use of Dabigatran Etexilate in Patients With Atrial Fibrillation After Mitral Valve Prosthetic Replacement Unknown status NCT03183843 Phase 4 Dabigatran Etexilate;Warfarin
2 Effects of the Administration Of Antithrombin on the Coagulation Status and on the Inflammatory Response in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
3 Clinical and Ultramicroscopic Myocardial Randomized Study of On-Pump Beating Heart Mitral Valve Replacement Completed NCT01641614 Phase 4
4 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
5 Rationale and Design of Dabigatran for Mitral Stenosis Atrial Fibrillation Trial Recruiting NCT04045093 Phase 4 Dabigatran etexilate;Warfarin
6 Efficacy and Safety of Rivaroxiban Compare With Vitamin K Antagonist Warfarin in Patients With Atrial Fibrillation and Mitral Stenosis Among Pakistani Population Withdrawn NCT03673605 Phase 4 Rivaroxaban 15 mg;Warfarin
7 Effect of Ivabradine vs Atenolol on Heart Rate and Effort Tolerance in Patients With Mild to Moderate Mitral Stenosis and Normal Sinus Rhythm Completed NCT01022463 Phase 3 Ivabradine;Atenolol
8 RIvoraxaban Safety and Efficacy in Patients With Mitral Stenosis Recruiting NCT03926156 Phase 3 Rivaroxaban;Warfarin
9 The Effect of Ramipril in Suppressing Gene Expression of Fibrosis in Cardiac Mitral Stenosis in Patients With Rheumatic Heart Disease Recruiting NCT03991910 Phase 3 Placebos;Ramipril 5Mg Oral Capsule
10 The Safety and Effectiveness of the SAPIEN 3 and SAPIEN 3 Ultra Valve in Patients With Symptomatic Severe Calcific Mitral Valve Disease With Severe Mitral Annular Calcification Who Are Not Candidates for Standard Mitral Valve Surgery. Recruiting NCT04408430 Phase 2, Phase 3
11 Pilot Trial of Bosentan for Secondary Pulmonary Hypertension Due to Severe Mitral Valve Dysfunction Unknown status NCT01270750 Phase 1, Phase 2 BOSENTAN
12 Surgical Ablation Versus No Surgical Ablation for Patients With Persistent or Longstanding Persistent Atrial Fibrillation (AF) Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
13 Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Recruiting NCT02830204 Phase 2
14 Quantification of Rheumatic Mitral Stenosis With Cardiac Magnetic Resonance Imaging and Comparison With Transthoracic Echocardiography Unknown status NCT00654472
15 A Randomized Trial of Mitral Valve Repair With Leaflet Resection Versus Leaflet Preservation on Functional Mitral Stenosis: The Canadian Mitral Research Alliance (CAMRA-1) Trial Unknown status NCT02552771
16 Post-Approval Study Protocol of the St. Jude Medical Biocor and Biocor Supra Valves Completed NCT00636987
17 Late (up to 12 Years) Clinical and Echocardiographic Outcomes of Percutaneous Transvenous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis: Continuing Secondary Antibiotic Prophylaxis Does Not Protect Against Late Events Completed NCT04112108
18 Early Percutaneous Mitral Intervention Versus Conventional Management in Asymptomatic Moderate Mitral Stenosis Completed NCT01406353
19 Logical Analysis of Data and Cardiac Surgery Risk Completed NCT00081666
20 Balloon Valvuloplasty Registry Completed NCT00005199
21 Tele-rehabilitation of Heart Patients Completed NCT01752192
22 Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study Completed NCT02375282
23 Impact of Acute Normovolemic Hemodilution on Whole Blood Coagulation Profile During Post-cardiopulmonary Bypass in Cardiac Surgery: Rotational Thromboelastometry Study Completed NCT02502448 hydroxyethyl starch (HES 130/0.6)
24 Does Acute Normovolemic Hemodilution Affect Intraoperative Value of Serum-creatinine Concentration in Patients Undergoing Cardiac Surgery? Completed NCT02831270 hydroxyethyl starch (HES 130/0.6)
25 Genome-wide Association Study of Susceptibility to Rheumatic Heart Disease in Fiji and New Caledonia Completed NCT02188862
26 Post-Approval Study for the MOSAIC® Bioprostheses: A Long Term Follow Up Study. Completed NCT01574625
27 Determination of Mitral Valve Area After Mitral Valve Repair Surgery for Mitral Stenosis Using 3-dimensional Transesophageal Echocardiography Completed NCT01694251
28 Neurologic Outcome After Mitral Valve Surgery Recruiting NCT03798015
29 Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement Investigational Device Exemption Recruiting NCT04717570
30 Inhibition of Aortic Valve Calcification Through the Carboxylation Mechanism of Matrix Gla Protein (MGP), Following Administration of Vitamin K2 (Menaquinone-7). Correlation With Mitral Annulus and Ascending Aorta Calcification. Recruiting NCT04429035
31 The Prospecive OBSERVational Munich Interventional MITRAl-Valve Registry Recruiting NCT04577248
32 Epidemiology and Long-term Prognosis of Patients With Valvular Heart Diseases (BIA-WAD Study) Recruiting NCT04527367
33 A Prospective, Multi-Center, Single-Arm Clinical Evaluation of the AVJ-514 System for the Treatment of Symptomatic Chronic Severe Mitral Regurgitation Active, not recruiting NCT02520310
34 French National Observatory of Percutaneous Mitral Commissurotomy (PMC) Immediate Score, Scanner, Late Results Active, not recruiting NCT02783248
35 ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Aortic and Mitral Bioprostheses (Models 11000A and 11000M) With a New Tissue Treatment Platform (COMMENCE) Active, not recruiting NCT01757665

Search NIH Clinical Center for Mitral Valve Stenosis

Cochrane evidence based reviews: mitral valve stenosis

Genetic Tests for Mitral Valve Stenosis

Genetic tests related to Mitral Valve Stenosis:

# Genetic test Affiliating Genes
1 Mitral Stenosis 29

Anatomical Context for Mitral Valve Stenosis

MalaCards organs/tissues related to Mitral Valve Stenosis:

Heart, Brain, Kidney, Liver, Skeletal Muscle, Neutrophil, Whole Blood

Publications for Mitral Valve Stenosis

Articles related to Mitral Valve Stenosis:

(show top 50) (show all 9814)
# Title Authors PMID Year
The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis. 54 61
17186137 2007
Plasma level of soluble P-selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty. 61 54
17131174 2007
Correlation of tissue selectin expression and hemodynamic parameters in rheumatic mitral valve disease. 54 61
17044373 2006
Effects of percutaneous balloon mitral valvuloplasty on plasma B-type natriuretic peptide in rheumatic mitral stenosis with and without atrial fibrillation. 54 61
16116870 2005
Left atrial diameter is a simple indicator of a deficiency in atrial natriuretic peptide secretion in patients with mitral stenosis: efficacy of postoperative supplementation with synthetic human alpha-atrial natriuretic peptide. 61 54
15550792 2004
Increased plasma levels of soluble P-selectin in rheumatic mitral stenosis. 61 54
15249442 2004
An abnormal systemic and regional hypercoagulable state in patients with mitral stenosis. 61 54
15061299 2004
Perioperative changes in atrial natriuretic peptide plasma levels associated with mitral and aortic valve replacement. 61 54
14973795 2004
Left atrial platelet activity with rheumatic mitral stenosis: correlation study of severity and platelet P-selectin expression by flow cytometry. 61 54
14605032 2003
Hypercoagulability existing in the local left atrium of patient with mitral stenosis. 61 54
12935411 2003
Neurohormones in mitral stenosis before and after percutaneous balloon mitral valvotomy. 54 61
12000158 2002
Low dose synthetic human atrial natriuretic peptide infusion in a patient with mitral stenosis and severe pulmonary hypertension. 61 54
10553928 1999
[Detection of CD62P (GMP-140) on peripheral blood platelet membrane in various heart diseases]. 54 61
7540229 1995
Effects of exercise on plasma level of brain natriuretic peptide in congestive heart failure with and without left ventricular dysfunction. 54 61
7817907 1995
Coagulation activity is increased in the left atrium of patients with mitral stenosis. 61 54
7646626 1995
Plasma atrial and brain natriuretic peptides in mitral stenosis treated by valvulotomy. 61 54
7874858 1994
[The acute and 24-hour modifications to the atrial natriuretic factor in patients who have undergone mitral valvuloplasty. The hemodynamic and echocardiographic correlations]. 61 54
8163101 1993
Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. 54 61
8425293 1993
Atrial natriuretic peptide and bronchial hyperresponsiveness in patients with mitral stenosis. 54 61
8341858 1993
Relationship between plasma atrial and brain natriuretic peptide concentration and hemodynamic parameters during percutaneous transvenous mitral valvulotomy in patients with mitral stenosis. 54 61
1442497 1992
Direct secretion from left atrium and pulmonary extraction of human atrial natriuretic peptide. 54 61
1532284 1992
Effects of percutaneous transvenous mitral commissurotomy on levels of plasma atrial natriuretic peptide during exercise. 54 61
1824734 1991
Time course of human atrial natriuretic factor release during cardiopulmonary bypass in mitral valve and coronary artery diseased patients. 54 61
1829375 1991
Stimulation of atrial natriuretic peptide and vasopressin during retrograde mitral valvuloplasty. 61 54
2147351 1990
Atrial natriuretic peptide response to postural changes in patients with left atrial hypertension. 61 54
1963407 1990
Atrial natriuretic peptide and vasopressin during percutaneous transvenous mitral valvuloplasty and relation to renin-angiotensin-aldosterone system and renal function. 54 61
2138848 1990
Baseline and post-atrial pacing release of atrial natriuretic factor in mitral stenosis. 61 54
2136967 1990
[Atrial natriuretic factor. Role in the physiopathology of cardiac and renal diseases]. 61 54
2137235 1990
Direct-Acting Oral Anticoagulants in Atrial Fibrillation: What's New in the Literature. 61
32332235 2021
Clinical and echocardiographic trends in percutaneous balloon mitral valvuloplasty. 61
33794935 2021
Long-term Clinical Impacts of Functional Mitral Stenosis After Mitral Valve Repair. 61
32980324 2021
Minimally Invasive Surgery for Hypertrophic Obstructive Cardiomyopathy With Mitral Regurgitation. 61
32805271 2021
Smith-Magenis syndrome: Report of morphological and new functional cardiac findings with review of the literature. 61
33811726 2021
Stroke prevention strategies in high-risk patients with atrial fibrillation. 61
33110242 2021
Mitral valve repair with artificial chordae replacement in children: a single-center experience. 61
33656741 2021
Left atrial structural and functional remodeling following balloon mitral valvuloplasty. 61
33211239 2021
Acute and Short-Term Outcomes of Percutaneous Transcatheter Mitral Valve Replacement in Children. 61
33722065 2021
A case report of inappropriate inhibition of ventricular pacing due to a unique pacemaker electrogram storage feature. 61
33768197 2021
Managing asymptomatic severe rheumatic mitral stenosis in pregnancy: a case report. 61
33693306 2021
An unusual case of spontaneous obstructive thrombus complicating rheumatic mitral stenosis. 61
33767492 2021
A new over-the-wire percutaneous mitral balloon valvuloplasty technique. 61
33788393 2021
Resurgence of the edge-to-edge repair of the mitral valve. 61
33395077 2021
Transcatheter Mitral Valve Implantation Systematic Review: Focus on Transseptal Approach and Mitral Annulus Calcification. 61
33687594 2021
Lessons from reoperations for mitral stenosis after mitral valve repair. 61
33431213 2021
Natriuretic peptide release during exercise in patients with valvular heart disease: A systematic review. 61
33683762 2021
Comparison of Clinical Characteristics, Natural History and Predictors of Disease Progression in Patients With Degenerative Mitral Stenosis Versus Rheumatic Mitral Stenosis. 61
33352211 2021
Prognostic value of left atrial volume index in patients with rheumatic mitral stenosis. 61
33405242 2021
Commentary: Reoperations for mitral stenosis after mitral valve repair: We are still learning. 61
33485658 2021
A Novel Assessment Using Projected Transmitral Gradient Improves Diagnostic Yield of Doppler Hemodynamics in Rheumatic and Calcific Mitral Stenosis. 61
33582068 2021
Mitral stenosis-related pulmonary embolism as a potential cause of vocal cord paralysis. 61
33762396 2021

Variations for Mitral Valve Stenosis

ClinVar genetic disease variations for Mitral Valve Stenosis:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LSM1 NM_014462.3(LSM1):c.231+4A>C SNV Uncertain significance 623485 rs775468919 GRCh37: 8:38027316-38027316
GRCh38: 8:38169798-38169798

Expression for Mitral Valve Stenosis

Search GEO for disease gene expression data for Mitral Valve Stenosis.

Pathways for Mitral Valve Stenosis

GO Terms for Mitral Valve Stenosis

Cellular components related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 VWF SERPINC1 SERPINA3 REN PPBP PLG
2 blood microparticle GO:0072562 9.72 SERPINC1 SERPINA3 PLG FGA F2
3 platelet alpha granule lumen GO:0031093 9.63 VWF SERPINA3 PPBP PLG PF4 FGA
4 collagen-containing extracellular matrix GO:0062023 9.61 VWF SERPINC1 SERPINA3 PLG PF4 NPPA
5 extracellular space GO:0005615 9.53 VWF SERPINC1 SERPINA3 SELP REN PPBP
6 platelet alpha granule GO:0031091 9.37 VWF FGA

Biological processes related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 SERPINA3 SELP PPBP PF4 CRP
2 cellular protein metabolic process GO:0044267 9.77 SERPINC1 PLG NPPA FGA F2
3 platelet activation GO:0030168 9.71 VWF PF4 FGA F2
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.65 PPBP PF4 F2
5 blood coagulation GO:0007596 9.63 VWF SERPINC1 PLG FGA F3 F2
6 acute-phase response GO:0006953 9.61 SERPINA3 F2 CRP
7 amyloid-beta metabolic process GO:0050435 9.58 REN ACE
8 regulation of blood coagulation GO:0030193 9.57 SERPINC1 F2
9 cardiac muscle hypertrophy in response to stress GO:0014898 9.56 NPPA ATP2A2
10 regulation of blood pressure GO:0008217 9.56 REN NPPB NPPA ACE
11 negative regulation of systemic arterial blood pressure GO:0003085 9.55 NPPB NPPA
12 angiotensin maturation GO:0002003 9.54 REN ACE
13 cGMP biosynthetic process GO:0006182 9.52 NPPB NPPA
14 negative regulation of fibrinolysis GO:0051918 9.51 PLG F2
15 fibrinolysis GO:0042730 9.5 PLG FGA F2
16 platelet degranulation GO:0002576 9.5 VWF SERPINA3 SELP PPBP PLG PF4
17 receptor guanylyl cyclase signaling pathway GO:0007168 9.49 NPPB NPPA
18 hemostasis GO:0007599 9.1 VWF SERPINC1 PLG FGA F3 F2

Molecular functions related to Mitral Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.43 REN PLG ACE
2 CXCR chemokine receptor binding GO:0045236 9.32 PPBP PF4
3 heparin binding GO:0008201 9.26 SERPINC1 SELP PF4 F2
4 hormone receptor binding GO:0051427 9.16 NPPB NPPA
5 signaling receptor binding GO:0005102 9.1 REN PLG NPPB NPPA FGA F2

Sources for Mitral Valve Stenosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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