MCID: MXD020
MIFTS: 30

Mixed Cell Adenoma

Categories: Cancer diseases

Aliases & Classifications for Mixed Cell Adenoma

MalaCards integrated aliases for Mixed Cell Adenoma:

Name: Mixed Cell Adenoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5385
NCIt 50 C4157
SNOMED-CT 67 89773001
UMLS 70 C0334323

Summaries for Mixed Cell Adenoma

Disease Ontology : 12 An adenoma that has material basis in more than one cell type.

MalaCards based summary : Mixed Cell Adenoma is related to mammographic density and donohue syndrome. An important gene associated with Mixed Cell Adenoma is CTSD (Cathepsin D), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. Related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection and Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line

Related Diseases for Mixed Cell Adenoma

Diseases related to Mixed Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 mammographic density 10.3 IGF1 ESR1
2 donohue syndrome 10.3 IRS1 IGF1 EGF
3 breast scirrhous carcinoma 10.2 ESR1 EGFR
4 benign breast adenomyoepithelioma 10.2 ESR1 EGFR
5 sebaceous adenoma 10.2 ESR1 EGF
6 breast metaplastic carcinoma 10.2 ESR1 EGFR
7 breast malignant phyllodes tumor 10.2 ESR1 EGFR
8 postmenopausal atrophic vaginitis 10.2 GNRH1 ESR1
9 progesterone-receptor negative breast cancer 10.2 ESR1 EGFR
10 thoracic benign neoplasm 10.1 ESR1 EGFR EGF
11 breast benign neoplasm 10.1 ESR1 EGFR EGF
12 prostatic hypertrophy 10.1 ESR1 EGFR EGF
13 insulin-like growth factor i 10.1 IRS1 IGF1 ESR1 EGF
14 pre-malignant neoplasm 10.1 ESR1 EGFR EGF
15 apocrine adenocarcinoma 10.1 ESR1 EGFR
16 in situ carcinoma 10.1 ESR1 EGFR EGF
17 breast carcinoma in situ 10.1 ESR1 EGFR EGF
18 cervical adenocarcinoma 10.1 ESR1 EGFR EGF
19 central precocious puberty 10.1 IGF1 GNRH1
20 pyometritis 10.1 GNRH1 AREG
21 keratosis pilaris atrophicans faciei 10.1 MAP2K1 EGFR
22 breast disease 10.1 IGF1 ESR1 EGF CTSD
23 amyotrophic lateral sclerosis 19 10.1 NRG1 ERBB4
24 leiomyoma 10.1 GNRH1 ESR1 EGF
25 endometrial disease 10.1 IGF1 GNRH1 ESR1
26 uterine benign neoplasm 10.1 IGF1 GNRH1 ESR1
27 reproductive organ benign neoplasm 10.1 IGF1 GNRH1 ESR1
28 fasting hypoglycemia 10.1 IGF1 CRH
29 mucinous adenocarcinoma 10.1 NRG1 ESR1 EGFR
30 diabetic encephalopathy 10.1 IRS1 IGF1
31 lung carcinoma in situ 10.1 EGFR EGF
32 teeth hard tissue disease 10.1 IGF1 GNRH1 ESR1
33 disorder of sexual development 10.1 IGF1 GNRH1 ESR1
34 aromatase excess syndrome 10.1 IGF1 GNRH1 ESR1
35 estrogen-receptor negative breast cancer 10.0 IGF1 ESR1 EGFR EGF
36 sheehan syndrome 10.0 IGF1 CRH
37 endometrial adenocarcinoma 10.0 IGF1 ESR1 EGFR EGF
38 pulmonary adenocarcinoma in situ 10.0 EGFR EGF
39 pituitary adenoma, prolactin-secreting 10.0 IGF1 GNRH1 ESR1
40 adult syndrome 10.0 IGF1 ESR1 CRH
41 autosomal dominant polycystic kidney disease 10.0 IGF1 EGFR EGF CTSD
42 sebaceous gland disease 10.0 IGF1 GNRH1 EGFR
43 myoma 10.0 GNRH1 ESR1 EGFR
44 suppression of tumorigenicity 12 10.0 MAP2K1 EGFR EGF
45 mucinous lung adenocarcinoma 10.0 NRG1 ERBB3
46 thyroid gland follicular carcinoma 9.9 ESR1 EGFR EGF
47 acth-secreting pituitary adenoma 9.9 IGF1 EGFR CRH
48 meningioma, familial 9.9 ESR1 EGFR EGF CTSD
49 mixed cerebral palsy 9.9 GNRH1 CRH
50 post-traumatic stress disorder 9.9 NRG1 ESR1 CRH

Graphical network of the top 20 diseases related to Mixed Cell Adenoma:



Diseases related to Mixed Cell Adenoma

Symptoms & Phenotypes for Mixed Cell Adenoma

GenomeRNAi Phenotypes related to Mixed Cell Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.13 EGFR ERBB4 PTK2B
2 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 8.62 ERBB4 MAP2K1

MGI Mouse Phenotypes related to Mixed Cell Adenoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.33 AREG BTC CRH CTSD EGF EGFR
2 homeostasis/metabolism MP:0005376 10.31 AREG BTC CRH CTSD EGFR ERBB3
3 cardiovascular system MP:0005385 10.3 AREG BTC EGFR ERBB3 ERBB4 ESR1
4 endocrine/exocrine gland MP:0005379 10.26 AREG CRH CTSD EGF EGFR ERBB3
5 cellular MP:0005384 10.25 CRH CTSD EGFR ERBB3 ERBB4 ESR1
6 immune system MP:0005387 10.22 AREG CRH CTSD EGF EGFR ERBB3
7 integument MP:0010771 10.18 AREG CRH CTSD EGF EGFR ERBB3
8 digestive/alimentary MP:0005381 10.15 AREG CTSD EGF EGFR ERBB3 EREG
9 muscle MP:0005369 9.97 BTC EGFR ERBB3 ERBB4 ESR1 HBEGF
10 normal MP:0002873 9.93 BTC CRH EGF EGFR ERBB3 ERBB4
11 neoplasm MP:0002006 9.8 EGFR ERBB3 EREG ESR1 GNRH1 IGF1
12 respiratory system MP:0005388 9.56 CRH EGFR ERBB3 ERBB4 ESR1 HBEGF
13 skeleton MP:0005390 9.28 BTC CRH EGFR ESR1 GNRH1 HBEGF

Drugs & Therapeutics for Mixed Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Mixed Cell Adenoma

Genetic Tests for Mixed Cell Adenoma

Anatomical Context for Mixed Cell Adenoma

Publications for Mixed Cell Adenoma

Articles related to Mixed Cell Adenoma:

# Title Authors PMID Year
1
Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma. 61
16932323 2006
2
Insulin receptor substrate-1 is over-expressed in glycogenotic but not in amphophilic preneoplastic hepatic foci induced in rats by N-nitrosomorpholine and dehydroepiandrosterone. 61
10403544 1999
3
[Clinical analysis of 17 patients with adrenal "incidentaloma"]. 61
12016808 1999
4
[The diagnosis and management of adrenal "incidentaloma"]. 61
7867431 1994
5
[Pathological analysis of 1458 cases of tumor in the sella turcica region]. 61
3219981 1988

Variations for Mixed Cell Adenoma

Expression for Mixed Cell Adenoma

Search GEO for disease gene expression data for Mixed Cell Adenoma.

Pathways for Mixed Cell Adenoma

Pathways related to Mixed Cell Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.24 WNT2 PTK2B NRG1 MAP2K1 IRS1 IGF1
2
Show member pathways
14.08 PTK2B NRG1 MAP2K1 IRS1 HBEGF EREG
3
Show member pathways
13.9 PTK2B NRG1 MAP2K1 IGF1 HBEGF GNRH1
4
Show member pathways
13.9 PTK2B NRG1 MAP2K1 IRS1 IGF1 HBEGF
5
Show member pathways
13.78 NRG1 MAP2K1 IRS1 HBEGF EREG ERBB4
6
Show member pathways
13.78 PTK2B NRG1 MAP2K1 IGF1 HBEGF GNRH1
7
Show member pathways
13.66 PTK2B NRG1 MAP2K1 IGF1 HBEGF GNRH1
8
Show member pathways
13.64 PTK2B NRG1 MAP2K1 IRS1 IGF1 GNRH1
9
Show member pathways
13.59 NRG1 MAP2K1 IRS1 HBEGF EREG ERBB4
10
Show member pathways
13.55 NRG1 IRS1 HBEGF EREG ERBB4 ERBB3
11
Show member pathways
13.52 PTK2B NRG1 IRS1 IGF1 GNRH1 ERBB4
12
Show member pathways
13.46 PTK2B NRG1 MAP2K1 IRS1 HBEGF EREG
13
Show member pathways
13.43 NRG1 MAP2K1 IGF1 HBEGF GNRH1 ERBB4
14
Show member pathways
13.4 PTK2B NRG1 IGF1 HBEGF GNRH1 EGFR
15
Show member pathways
13.35 WNT2 NRG1 MAP2K1 IGF1 GNRH1 ESR1
16
Show member pathways
13.24 NRG1 IRS1 HBEGF EREG ERBB4 ERBB3
17
Show member pathways
13.19 PTK2B NRG1 MAP2K1 IGF1 HBEGF GNRH1
18
Show member pathways
13.17 PTK2B NRG1 MAP2K1 IRS1 IGF1 HBEGF
19
Show member pathways
13.12 PTK2B NRG1 MAP2K1 IRS1 IGF1 HBEGF
20
Show member pathways
13.11 PTK2B MAP2K1 IRS1 IGF1 HBEGF EGFR
21
Show member pathways
13.11 WNT2 MAP2K1 IRS1 IGF1 EREG ERBB4
22
Show member pathways
13.09 WNT2 MAP2K1 HBEGF EGFR EGF CRH
23
Show member pathways
13.01 PTK2B MAP2K1 IRS1 IGF1 ERBB3 EGFR
24
Show member pathways
12.98 PTK2B MAP2K1 IRS1 IGF1 ERBB4 ERBB3
25
Show member pathways
12.98 MAP2K1 IRS1 IGF1 EREG EGFR EGF
26
Show member pathways
12.93 PTK2B MAP2K1 IGF1 EGFR EGF
27 12.92 WNT2 MAP2K1 IGF1 ESR1 EGFR EGF
28 12.91 MAP2K1 IGF1 EREG ERBB4 ERBB3 EGFR
29
Show member pathways
12.86 NRG1 IRS1 HBEGF EREG ERBB4 ERBB3
30
Show member pathways
12.85 WNT2 MAP2K1 IGF1 ESR1 EGFR EGF
31
Show member pathways
12.84 NRG1 IGF1 GNRH1 EGFR EGF BTC
32
Show member pathways
12.82 MAP2K1 IRS1 IGF1 HBEGF ESR1 ERBB3
33
Show member pathways
12.81 PTK2B NRG1 MAP2K1 IRS1 ESR1 ERBB3
34
Show member pathways
12.81 MAP2K1 IRS1 IGF1 HBEGF ESR1 EGFR
35
Show member pathways
12.75 PTK2B MAP2K1 IGF1 HBEGF GNRH1 EGFR
36
Show member pathways
12.72 PTK2B MAP2K1 IRS1 IGF1 HBEGF EGFR
37
Show member pathways
12.66 WNT2 MAP2K1 IRS1 IGF1 ERBB4 ERBB3
38 12.56 MAP2K1 IRS1 ERBB3 EGFR
39
Show member pathways
12.51 MAP2K1 IRS1 ESR1 CTSD
40 12.49 PTK2B ERBB4 ERBB3 EGFR EGF
41
Show member pathways
12.48 MAP2K1 ERBB4 ERBB3 EGFR
42
Show member pathways
12.47 NRG1 MAP2K1 IRS1 IGF1 ESR1 ERBB3
43
Show member pathways
12.47 NRG1 MAP2K1 IGF1 GNRH1 ERBB4 ERBB3
44
Show member pathways
12.45 PTK2B MAP2K1 EGFR EGF
45 12.45 WNT2 MAP2K1 IGF1 HBEGF ESR1 ERBB4
46
Show member pathways
12.45 NRG1 MAP2K1 IGF1 HBEGF EREG ERBB4
47
Show member pathways
12.44 PTK2B MAP2K1 EGFR EGF
48
Show member pathways
12.42 PTK2B MAP2K1 IRS1 EGFR AREG
49
Show member pathways
12.42 NRG1 IGF1 HBEGF GNRH1 EGFR BTC
50
Show member pathways
12.41 NRG1 HBEGF EREG ERBB4 ERBB3 EGFR

GO Terms for Mixed Cell Adenoma

Cellular components related to Mixed Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.1 PTK2B NRG1 MAP2K1 IRS1 HBEGF ESR1
2 extracellular region GO:0005576 10 WNT2 NRG1 IGF1 HBEGF GNRH1 EREG
3 extracellular space GO:0005615 9.77 WNT2 NRG1 IGF1 HBEGF GNRH1 EREG
4 basal plasma membrane GO:0009925 9.43 ERBB4 ERBB3 EGFR
5 clathrin-coated vesicle membrane GO:0030665 9.1 HBEGF EREG EGFR EGF BTC AREG

Biological processes related to Mixed Cell Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 PTK2B NRG1 MAP2K1 IRS1 IGF1 HBEGF
2 positive regulation of transcription, DNA-templated GO:0045893 10.15 MAP2K1 IGF1 ESR1 ERBB4 EGFR EGF
3 negative regulation of apoptotic process GO:0043066 10.12 PTK2B IGF1 GNRH1 ERBB4 EGFR BTC
4 protein phosphorylation GO:0006468 10.11 PTK2B MAP2K1 ERBB4 ERBB3 EGFR
5 positive regulation of gene expression GO:0010628 10.11 NRG1 MAP2K1 IGF1 ERBB3 EGF CRH
6 negative regulation of cell proliferation GO:0008285 10.08 PTK2B MAP2K1 GNRH1 EREG ERBB4
7 positive regulation of cell migration GO:0030335 10.03 PTK2B IGF1 HBEGF EGFR EGF
8 negative regulation of gene expression GO:0010629 10.01 MAP2K1 IGF1 ESR1 CRH
9 heart development GO:0007507 10 NRG1 MAP2K1 ERBB4 ERBB3
10 membrane organization GO:0061024 10 HBEGF EREG EGFR EGF BTC AREG
11 cell-cell signaling GO:0007267 9.99 WNT2 GNRH1 EREG AREG
12 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.99 PTK2B MAP2K1 ERBB4 EGFR
13 peptidyl-tyrosine phosphorylation GO:0018108 9.99 PTK2B MAP2K1 ERBB4 ERBB3 EGFR EGF
14 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.98 PTK2B NRG1 ERBB4 ERBB3 EGFR
15 wound healing GO:0042060 9.97 NRG1 IGF1 EREG ERBB3 EGFR
16 activation of MAPK activity GO:0000187 9.96 NRG1 MAP2K1 IGF1 EGF
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.95 PTK2B NRG1 IGF1 HBEGF EGF AREG
18 epidermal growth factor receptor signaling pathway GO:0007173 9.95 PTK2B HBEGF EREG EGFR EGF BTC
19 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.92 IGF1 ERBB4 ERBB3 EGF
20 positive regulation of cell growth GO:0030307 9.92 PTK2B NRG1 HBEGF EGFR
21 regulation of cell motility GO:2000145 9.92 NRG1 HBEGF EREG ERBB4 ERBB3 EGFR
22 response to peptide hormone GO:0043434 9.91 IRS1 GNRH1 EREG AREG
23 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.91 HBEGF EREG EGFR EGF BTC AREG
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 IGF1 HBEGF EREG EGFR
25 positive regulation of protein kinase B signaling GO:0051897 9.9 NRG1 IRS1 HBEGF ESR1 EREG ERBB4
26 response to estradiol GO:0032355 9.89 ESR1 EGFR AREG
27 muscle organ development GO:0007517 9.89 NRG1 IGF1 HBEGF
28 positive regulation of fibroblast proliferation GO:0048146 9.89 WNT2 IGF1 ESR1 EREG BTC
29 positive regulation of kinase activity GO:0033674 9.87 ERBB4 ERBB3 EGFR
30 positive regulation of phosphorylation GO:0042327 9.87 EREG EGFR EGF AREG
31 positive regulation of protein kinase activity GO:0045860 9.86 PTK2B NRG1 EREG
32 positive regulation of mitotic nuclear division GO:0045840 9.86 IGF1 EREG EGF BTC
33 ERBB2 signaling pathway GO:0038128 9.86 NRG1 HBEGF EREG ERBB4 ERBB3 EGFR
34 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.85 HBEGF EREG EGF BTC AREG
35 positive regulation of protein tyrosine kinase activity GO:0061098 9.84 NRG1 ERBB3 EGF
36 positive regulation of cardiac muscle cell proliferation GO:0060045 9.84 WNT2 NRG1 ERBB4
37 mammary gland alveolus development GO:0060749 9.84 ESR1 ERBB4 EGF AREG
38 phosphatidylinositol 3-kinase signaling GO:0014065 9.83 IRS1 IGF1 ERBB3
39 ERK1 and ERK2 cascade GO:0070371 9.83 MAP2K1 IGF1 EGF
40 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.82 PTK2B IRS1 ERBB4
41 positive regulation of DNA replication GO:0045740 9.81 EREG EGFR EGF
42 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.79 NRG1 IGF1 ERBB3
43 negative regulation of neuron migration GO:2001223 9.77 NRG1 GNRH1 ERBB4
44 MAPK cascade GO:0000165 9.73 PTK2B NRG1 MAP2K1 IRS1 HBEGF EREG
45 positive regulation of glycogen biosynthetic process GO:0045725 9.72 IRS1 IGF1
46 negative regulation of secretion GO:0051048 9.72 NRG1 ERBB3 EGF
47 insulin-like growth factor receptor signaling pathway GO:0048009 9.71 IRS1 IGF1
48 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 9.71 NRG1 EGF
49 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.7 MAP2K1 EGFR
50 ovulation cycle GO:0042698 9.7 GNRH1 EGFR

Molecular functions related to Mixed Cell Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.88 PTK2B MAP2K1 ERBB4 ERBB3 EGFR
2 signaling receptor binding GO:0005102 9.72 WNT2 PTK2B NRG1 EGFR CRH
3 protein tyrosine kinase activity GO:0004713 9.55 PTK2B MAP2K1 ERBB4 ERBB3 EGFR
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 ERBB4 ERBB3 EGFR
5 growth factor activity GO:0008083 9.5 NRG1 IGF1 HBEGF EREG EGF BTC
6 insulin-like growth factor receptor binding GO:0005159 9.49 IRS1 IGF1
7 protein tyrosine kinase activator activity GO:0030296 9.46 NRG1 ERBB3
8 nitric-oxide synthase regulator activity GO:0030235 9.43 ESR1 EGFR
9 transmembrane receptor protein tyrosine kinase activator activity GO:0030297 9.4 NRG1 EGF
10 ErbB-3 class receptor binding GO:0043125 9.26 NRG1 ERBB3
11 epidermal growth factor receptor binding GO:0005154 9.1 HBEGF EREG ERBB4 EGF BTC AREG

Sources for Mixed Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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