MCID: MXD023
MIFTS: 45

Mixed Cell Type Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Mixed Cell Type Cancer

MalaCards integrated aliases for Mixed Cell Type Cancer:

Name: Mixed Cell Type Cancer 12 15
Mixed Tumor, Malignant 12 44
Malignant Mixed Tumor 12 73
Mixed Neoplasm 12 73
Malignant Mixed Tumor, Not Otherwise Specified 73
Mixed Tumor, Not Otherwise Specified 73
Mixed Salivary Gland Tumor 73
Malignant Mixed Neoplasm 12
Malignant Mixed Cancer 12
Mixed Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:154
MeSH 44 D018198
NCIt 50 C3729 C6930
SNOMED-CT 68 189802003 8145008

Summaries for Mixed Cell Type Cancer

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from two germinal layers of tissue.

MalaCards based summary : Mixed Cell Type Cancer, also known as mixed tumor, malignant, is related to uterine body mixed cancer and pleomorphic adenoma carcinoma. An important gene associated with Mixed Cell Type Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Developmental Biology and Cytokine Signaling in Immune system. The drugs Gemcitabine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland and skin, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Mixed Cell Type Cancer

Diseases related to Mixed Cell Type Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 uterine body mixed cancer 31.2 ERBB2 KIT PGR PPP2R1A TP53
2 pleomorphic adenoma carcinoma 29.7 ENO2 ERBB2 TP53
3 eccrine mixed tumor of skin 12.1
4 mixed lacrimal gland cancer 11.0
5 carcinosarcoma of the cervix uteri 11.0
6 adult mesoblastic nephroma 10.9
7 uterine corpus adenosarcoma 10.9
8 cervical adenoma malignum 10.9 KRT7 MME
9 ovary neuroendocrine neoplasm 10.9 KRT7 SYP
10 jejunal cancer 10.9 KIT KRT7
11 meninges sarcoma 10.9 MB TP53
12 ovarian large-cell neuroendocrine carcinoma 10.9 KRT7 SYP
13 eccrine sweat gland neoplasm 10.9 KRT7 TP53
14 cervical mucinous adenocarcinoma 10.8 KRT7 MME
15 lung combined type small cell carcinoma 10.8 MME SYP
16 gallbladder squamous cell carcinoma 10.8 ERBB2 TP53
17 cellular ependymoma 10.8 SYP TP53
18 gastric papillary adenocarcinoma 10.8 ERBB2 TP53
19 clear cell papillary renal cell carcinoma 10.8 KRT7 MME
20 fallopian tube endometrioid adenocarcinoma 10.8 ERBB2 MME
21 uterine corpus serous adenocarcinoma 10.8 ERBB2 TP53
22 endometrium carcinoma in situ 10.8 PGR TP53
23 breast neuroendocrine neoplasm 10.8 ERBB2 SYP
24 sclerosing liposarcoma 10.8 MB TP53
25 endosalpingiosis 10.7 KRT7 PGR
26 inverted transitional papilloma 10.7 KRT5 KRT7
27 benign breast adenomyoepithelioma 10.7 KRT5 KRT7
28 mixed type thymoma 10.7 KIT SYP
29 breast malignant phyllodes tumor 10.7 PGR TP53
30 scirrhous adenocarcinoma 10.7 ERBB2 PGR
31 breast apocrine carcinoma 10.7 ERBB2 PGR
32 pleomorphic carcinoma 10.7 KIT KRT7 TP53
33 malignant leydig cell tumor 10.7 KIT KRT7 MME
34 olfactory groove meningioma 10.7 PGR TP53
35 non-proliferative fibrocystic change of the breast 10.7 ERBB2 TP53
36 bladder carcinoma in situ 10.7 KRT7 TP53
37 kidney benign neoplasm 10.7 KIT KRT7 MME
38 vulvar intraepithelial neoplasia 10.7 KRT5 TP53
39 breast mucoepidermoid carcinoma 10.7 ERBB2 PGR
40 endometrial clear cell adenocarcinoma 10.6 ESR1 TP53
41 bile duct mucoepidermoid carcinoma 10.6 KRT5 KRT7
42 vulval paget's disease 10.6 ERBB2 KRT7
43 renal oncocytoma 10.6 KIT KRT7 MME
44 intracystic papillary adenoma 10.6 ERBB2 PGR
45 breast myofibroblastoma 10.6 ESR1 MME
46 intratubular embryonal carcinoma 10.6 KIT KRT7
47 ovarian brenner tumor 10.6 KIT KRT7 MME
48 spindle cell synovial sarcoma 10.6 KIT KRT7 MB
49 keratinizing squamous cell carcinoma 10.6 KRT5 TP53
50 progesterone-receptor negative breast cancer 10.6 ERBB2 PGR

Graphical network of the top 20 diseases related to Mixed Cell Type Cancer:



Diseases related to Mixed Cell Type Cancer

Symptoms & Phenotypes for Mixed Cell Type Cancer

GenomeRNAi Phenotypes related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.28 ERBB2 ESR1 HRAS KIT KRAS KRT7

MGI Mouse Phenotypes related to Mixed Cell Type Cancer:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 PPP2R1A SYP TP53 ENO2 ERBB2 HRAS
2 homeostasis/metabolism MP:0005376 10.22 TP53 PPP2R1A ERBB2 HRAS ESR1 KRAS
3 cellular MP:0005384 10.2 TP53 PGR ESR1 ENO2 ERBB2 KRAS
4 growth/size/body region MP:0005378 10.19 TP53 PPP2R1A ESR1 ENO2 ERBB2 HRAS
5 cardiovascular system MP:0005385 10.16 TP53 PGR ESR1 HRAS ERBB2 KRAS
6 integument MP:0010771 10.11 TP53 ERBB2 HRAS ESR1 KIT MME
7 mortality/aging MP:0010768 10.1 TP53 PGR PPP2R1A ESR1 ERBB2 HRAS
8 craniofacial MP:0005382 10.08 TP53 ENO2 ERBB2 HRAS KIT KRT5
9 digestive/alimentary MP:0005381 10.07 TP53 ESR1 ERBB2 HRAS KRAS KIT
10 embryo MP:0005380 10.05 TP53 PGR ESR1 ERBB2 KRAS KIT
11 limbs/digits/tail MP:0005371 9.98 TP53 ERBB2 ESR1 KIT PGR KRT5
12 neoplasm MP:0002006 9.92 PPP2R1A TP53 ERBB2 HRAS ESR1 KIT
13 muscle MP:0005369 9.91 TP53 ESR1 ERBB2 KRAS PGR KIT
14 normal MP:0002873 9.81 PPP2R1A SYP TP53 ERBB2 HRAS ESR1
15 no phenotypic analysis MP:0003012 9.8 TP53 ESR1 HRAS KRAS PGR KIT
16 renal/urinary system MP:0005367 9.43 TP53 ESR1 HRAS KRAS KIT KRT7
17 respiratory system MP:0005388 9.23 TP53 ENO2 ERBB2 HRAS ESR1 KIT

Drugs & Therapeutics for Mixed Cell Type Cancer

Drugs for Mixed Cell Type Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antimetabolites, Antineoplastic Phase 2
5 Antiviral Agents Phase 2
6 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
2 Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients Recruiting NCT03458728 Phase 1, Phase 2 BAY806946
3 Study of Imaging Characteristics OCT of Skin Lesions Requiring Biopsy / Resection Not yet recruiting NCT02851693 Not Applicable

Search NIH Clinical Center for Mixed Cell Type Cancer

Cochrane evidence based reviews: mixed tumor, malignant

Genetic Tests for Mixed Cell Type Cancer

Anatomical Context for Mixed Cell Type Cancer

MalaCards organs/tissues related to Mixed Cell Type Cancer:

41
Salivary Gland, Skin

Publications for Mixed Cell Type Cancer

Articles related to Mixed Cell Type Cancer:

# Title Authors Year
1
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
2
Carcinosarcoma of parotid gland (malignant mixed tumor). ( 26981480 )
2015
3
Pulmonary salivary gland-type tumors with features of malignant mixed tumor (carcinoma ex pleomorphic adenoma): a clinicopathologic study of five cases. ( 22031319 )
2011
4
Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. ( 15262430 )
2004
5
Malignant mixed tumor ex eccrine spiradenoma: an unusual pattern of malignant dedifferentiation. ( 11436169 )
2001
6
Nonsyntenic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland. ( 9723034 )
1998
7
Malignant mixed tumor of the skin (malignant chondroid syringoma). ( 7991276 )
1994
8
True malignant mixed tumor of the submandibular gland. ( 2160184 )
1990
9
Malignant mixed tumor of the skin: malignant chondroid syringoma. ( 6279274 )
1982

Variations for Mixed Cell Type Cancer

Expression for Mixed Cell Type Cancer

Search GEO for disease gene expression data for Mixed Cell Type Cancer.

Pathways for Mixed Cell Type Cancer

Pathways related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 ERBB2 HRAS KIT KRAS KRT5 KRT7
2
Show member pathways
13.28 ERBB2 HRAS KIT KRAS PPP2R1A TP53
3
Show member pathways
13.18 ERBB2 ESR1 HRAS KIT KRAS PPP2R1A
4
Show member pathways
12.95 ESR1 HRAS KRAS PGR PPP2R1A
5
Show member pathways
12.84 ERBB2 HRAS KIT KRAS PPP2R1A TP53
6
Show member pathways
12.77 ERBB2 HRAS KIT KRAS TP53
7
Show member pathways
12.64 ERBB2 ESR1 HRAS KRAS TP53
8 12.63 ERBB2 HRAS KIT KRAS TP53
9 12.6 ERBB2 ESR1 HRAS KIT KRAS TP53
10
Show member pathways
12.59 HRAS KRAS PPP2R1A TP53
11
Show member pathways
12.59 ERBB2 ESR1 HRAS KRAS TP53
12
Show member pathways
12.51 ERBB2 HRAS KRAS TP53
13
Show member pathways
12.48 ERBB2 HRAS KIT KRAS PPP2R1A TP53
14
Show member pathways
12.46 ERBB2 HRAS KRAS TP53
15 12.44 ERBB2 HRAS KRAS TP53
16
Show member pathways
12.41 ERBB2 HRAS KRAS TP53
17
Show member pathways
12.4 ERBB2 ESR1 HRAS KRAS
18
Show member pathways
12.39 ERBB2 HRAS KRAS TP53
19
Show member pathways
12.36 ERBB2 HRAS KRAS TP53
20
Show member pathways
12.17 ERBB2 ESR1 HRAS KIT KRAS PGR
21 12.05 ERBB2 HRAS KRAS TP53
22
Show member pathways
11.99 ERBB2 HRAS KRAS
23
Show member pathways
11.96 HRAS KRAS PPP2R1A
24 11.96 ERBB2 ESR1 HRAS KRAS TP53
25 11.94 HRAS KRAS PPP2R1A TP53
26 11.91 HRAS KRAS PPP2R1A
27 11.9 HRAS KRAS TP53
28 11.87 HRAS KRAS PPP2R1A TP53
29 11.84 ESR1 HRAS KRAS TP53
30 11.82 ERBB2 HRAS KRAS TP53
31
Show member pathways
11.8 ERBB2 ESR1 KIT
32
Show member pathways
11.73 HRAS KIT KRAS
33 11.61 ERBB2 HRAS TP53
34 11.6 HRAS KRAS TP53
35
Show member pathways
11.59 HRAS KRAS PPP2R1A
36
Show member pathways
11.59 ERBB2 ESR1 HRAS KRAS PGR
37 11.55 HRAS KRAS PPP2R1A
38 11.51 ERBB2 HRAS KRAS
39 11.49 ERBB2 HRAS KRAS TP53
40 11.4 ESR1 HRAS KRAS
41 11.26 HRAS KRAS TP53
42 11.16 ERBB2 HRAS KRAS
43 10.97 ESR1 HRAS KRAS
44 10.83 ERBB2 HRAS KIT KRAS TP53
45 10.78 HRAS KRAS

GO Terms for Mixed Cell Type Cancer

Cellular components related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.93 ENO2 ERBB2 ESR1 HRAS KIT KRAS
2 cytoplasm GO:0005737 9.73 ENO2 ERBB2 ESR1 HRAS KIT KRAS
3 cytosol GO:0005829 9.36 ENO2 ERBB2 ESR1 HRAS KRAS KRT5

Biological processes related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.73 ERBB2 HRAS KIT KRAS
2 phosphatidylinositol phosphorylation GO:0046854 9.67 ERBB2 ESR1 KIT
3 positive regulation of gene expression GO:0010628 9.65 ERBB2 HRAS KIT KRAS TP53
4 Ras protein signal transduction GO:0007265 9.54 HRAS KRAS TP53
5 replicative senescence GO:0090399 9.48 MME TP53
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.46 ESR1 TP53
7 positive regulation of phospholipase C activity GO:0010863 9.4 ESR1 KIT
8 ERBB2 signaling pathway GO:0038128 9.33 ERBB2 HRAS KRAS
9 response to isolation stress GO:0035900 9.32 HRAS KRAS
10 regulation of long-term neuronal synaptic plasticity GO:0048169 9.13 HRAS KRAS SYP
11 positive regulation of MAP kinase activity GO:0043406 8.92 ERBB2 HRAS KIT KRAS

Molecular functions related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 ERBB2 KIT
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 ESR1 KIT

Sources for Mixed Cell Type Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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