MCID: MXD023
MIFTS: 41

Mixed Cell Type Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Mixed Cell Type Cancer

MalaCards integrated aliases for Mixed Cell Type Cancer:

Name: Mixed Cell Type Cancer 12 15
Mixed Tumor, Malignant 12 44
Malignant Mixed Tumor 12 73
Mixed Neoplasm 12 73
Malignant Mixed Tumor, Not Otherwise Specified 73
Mixed Tumor, Not Otherwise Specified 73
Mixed Salivary Gland Tumor 73
Malignant Mixed Neoplasm 12
Malignant Mixed Cancer 12
Mixed Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:154
MeSH 44 D018198
NCIt 50 C3729 C6930
SNOMED-CT 68 8145008

Summaries for Mixed Cell Type Cancer

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from two germinal layers of tissue.

MalaCards based summary : Mixed Cell Type Cancer, also known as mixed tumor, malignant, is related to ovarian carcinosarcoma and uterine body mixed cancer. An important gene associated with Mixed Cell Type Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gastric cancer and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include salivary gland, skin and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Mixed Cell Type Cancer

Diseases related to Mixed Cell Type Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 ovarian carcinosarcoma 32.1 ERBB2 SYP
2 uterine body mixed cancer 32.1 ERBB2 PGR PPP2R1A TP53
3 carcinosarcoma 31.4 ERBB2 HRAS KIT KRT7 MME PGR
4 pleomorphic adenoma carcinoma 30.1 ERBB2 TP53
5 thymoma, familial 30.0 HRAS KIT
6 histiocytoma 30.0 KIT MB TP53
7 adenocarcinoma 29.8 ERBB2 HRAS KIT TP53
8 malignant mesenchymoma 29.7 KIT MB TP53
9 mucoepidermoid carcinoma 29.6 CEACAM5 ERBB2 KRT7
10 necrotizing sialometaplasia 29.5 KIT KRT7 TP53
11 adenosarcoma 29.4 KIT MB MME PGR TP53
12 leiomyosarcoma 29.4 ENO2 KIT MB PGR TP53
13 lung cancer susceptibility 3 29.1 CEACAM5 ERBB2 HRAS KRT7 TP53
14 cystadenocarcinoma 28.7 CEACAM5 ERBB2 HRAS KRT7 PGR PPP2R1A
15 eccrine mixed tumor of skin 12.1
16 mixed lacrimal gland cancer 11.2
17 carcinosarcoma of the cervix uteri 11.1
18 adult mesoblastic nephroma 11.1
19 uterine corpus adenosarcoma 11.1
20 adenomyoma 11.0
21 papillary glioneuronal tumors 11.0
22 wilms tumor 6 11.0
23 vaginal spindle cell epithelioma 11.0
24 balloon cell malignant melanoma 10.4 KRT7 MME
25 ovarian germ cell cancer 10.4 AFP KRT7
26 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
27 cervical adenoma malignum 10.4 KRT7 MME
28 jejunal cancer 10.4 KIT KRT7
29 meninges sarcoma 10.4 MB TP53
30 neonatal myasthenia gravis 10.4 AFP MB
31 renal pelvis adenocarcinoma 10.4 AFP KRT7
32 intrahepatic bile duct adenoma 10.4 AFP KRT7
33 ovary neuroendocrine neoplasm 10.3 KRT7 SYP
34 cellular ependymoma 10.3 SYP TP53
35 ceruminoma 10.3 KIT KRT7
36 hepatic angiomyolipoma 10.3 AFP KIT
37 lung combined type small cell carcinoma 10.3 MME SYP
38 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
39 breast malignant phyllodes tumor 10.3 PGR TP53
40 brain germinoma 10.3 AFP POU5F1
41 endosalpingiosis 10.3 KRT7 PGR
42 extragonadal germ cell cancer 10.3 AFP POU5F1
43 central nervous system germ cell tumor 10.3 AFP POU5F1
44 endometrium carcinoma in situ 10.3 PGR TP53
45 mixed germ cell tumor 10.3 AFP KIT
46 fallopian tube endometrioid adenocarcinoma 10.3 ERBB2 MME
47 embryonal testis carcinoma 10.3 AFP POU5F1
48 ovarian embryonal carcinoma 10.3 AFP POU5F1
49 eccrine papillary adenocarcinoma 10.3 KRT7 PGR
50 myxoid leiomyosarcoma 10.3 MME PGR

Graphical network of the top 20 diseases related to Mixed Cell Type Cancer:



Diseases related to Mixed Cell Type Cancer

Symptoms & Phenotypes for Mixed Cell Type Cancer

GenomeRNAi Phenotypes related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1

MGI Mouse Phenotypes related to Mixed Cell Type Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 AFP ENO2 ERBB2 HRAS KIT PGR
2 neoplasm MP:0002006 9.5 AFP ERBB2 HRAS KIT PGR PPP2R1A
3 normal MP:0002873 9.23 ERBB2 HRAS KIT PGR POU5F1 PPP2R1A

Drugs & Therapeutics for Mixed Cell Type Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Cell Type Cancer

Cochrane evidence based reviews: mixed tumor, malignant

Genetic Tests for Mixed Cell Type Cancer

Anatomical Context for Mixed Cell Type Cancer

MalaCards organs/tissues related to Mixed Cell Type Cancer:

41
Salivary Gland, Skin, Lung, Liver, Ovary, Cervix, Testis

Publications for Mixed Cell Type Cancer

Articles related to Mixed Cell Type Cancer:

(show all 21)
# Title Authors Year
1
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
2
Carcinosarcoma of parotid gland (malignant mixed tumor). ( 26981480 )
2015
3
Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region. ( 26600963 )
2015
4
Malignant Mixed Tumor of the Hard Palate. ( 26172359 )
2015
5
Pulmonary salivary gland-type tumors with features of malignant mixed tumor (carcinoma ex pleomorphic adenoma): a clinicopathologic study of five cases. ( 22031319 )
2011
6
Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma. ( 19373913 )
2009
7
Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. ( 15262430 )
2004
8
True malignant mixed tumor (carcinosarcoma) of parotid gland : a case report. ( 15471136 )
2004
9
Orbital metastasis and intraocular invasion of malignant mixed tumor (carcinosarcoma) of the parotid gland in a child. ( 14718308 )
2004
10
Malignant pleomorphic adenoma (malignant mixed tumor) of the trachea: a case report and review of the literature. ( 12582787 )
2003
11
Carcinosarcoma (malignant mixed tumor) of the submandibular gland: A case report and review of the literature. ( 12215996 )
2002
12
Malignant mixed tumor ex eccrine spiradenoma: an unusual pattern of malignant dedifferentiation. ( 11436169 )
2001
13
Carcinosarcoma (malignant mixed tumor) of the parotid gland: a case report. ( 11326392 )
2001
14
True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component: a case report and review of the literature. ( 11371238 )
2001
15
Histomorphological investigation regarding to malignant transformation of pleomorphic adenoma (so-called malignant mixed tumor) of the salivary gland origin: special reference to carcinosarcoma. ( 11197153 )
2000
16
Malignant fibrous histiocytoma (giant cell type) associated with a malignant mixed tumor in the salivary gland of a dog. ( 10896399 )
2000
17
Nonsyntenic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland. ( 9723034 )
1998
18
Fine needle aspiration diagnosis of malignant mixed tumor (carcinosarcoma) arising in pleomorphic adenoma of the salivary gland. A case report. ( 9684598 )
1998
19
Malignant mixed tumor of the skin (malignant chondroid syringoma). ( 7991276 )
1994
20
True malignant mixed tumor of the submandibular gland. ( 2160184 )
1990
21
Malignant mixed tumor of the skin: malignant chondroid syringoma. ( 6279274 )
1982

Variations for Mixed Cell Type Cancer

Expression for Mixed Cell Type Cancer

Search GEO for disease gene expression data for Mixed Cell Type Cancer.

Pathways for Mixed Cell Type Cancer

Pathways related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 ERBB2 HRAS KIT PGR TP53
2
Show member pathways
12.19 ERBB2 HRAS KIT PPP2R1A TP53
3 11.41 ERBB2 HRAS TP53
4 11.25 ERBB2 HRAS TP53
5 10.86 KIT POU5F1 ZFP42
6 10.74 ERBB2 HRAS KIT TP53

GO Terms for Mixed Cell Type Cancer

Cellular components related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 AFP ENO2 ERBB2 HRAS KIT KRT7

Biological processes related to Mixed Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phospholipase C activity GO:0010863 9.32 HRAS KIT
2 replicative senescence GO:0090399 9.26 MME TP53
3 ovulation from ovarian follicle GO:0001542 9.16 AFP PGR
4 positive regulation of MAP kinase activity GO:0043406 9.13 ERBB2 HRAS KIT
5 positive regulation of gene expression GO:0010628 9.02 ERBB2 HRAS KIT POU5F1 TP53

Sources for Mixed Cell Type Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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