Mixed Cerebral Palsy

Categories: Neuronal diseases

Aliases & Classifications for Mixed Cerebral Palsy

MalaCards integrated aliases for Mixed Cerebral Palsy:

Name: Mixed Cerebral Palsy 12 15
Cerebral Palsy, Mixed 71


External Ids:

Disease Ontology 12 DOID:0050673
UMLS 71 C0751024

Summaries for Mixed Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing.

MalaCards based summary : Mixed Cerebral Palsy, also known as cerebral palsy, mixed, is related to cerebral palsy and inhibited male orgasm. An important gene associated with Mixed Cerebral Palsy is SLC16A2 (Solute Carrier Family 16 Member 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Beta-Adrenergic Signaling. Affiliated tissues include pituitary, brain and thyroid, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Mixed Cerebral Palsy

Diseases related to Mixed Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 cerebral palsy 12.2
2 inhibited male orgasm 10.4 SLC6A3 SHBG
3 amphetamine abuse 10.3 SLC6A3 DRD5 DRD4
4 postmenopausal atrophic vaginitis 10.3 SHBG GNRH1
5 early-onset schizophrenia 10.3 DRD2 DRD1
6 dissociated nystagmus 10.3 JRK HECTD4
7 polysubstance abuse 10.3 DRD3 DRD2
8 hypoadrenalism 10.3 SHBG CRH
9 graves disease 1 10.3 TRH SLC16A2 SHBG
10 thyroid hormone resistance, generalized, autosomal dominant 10.3 TRH SLC16A2 SHBG
11 tardive dyskinesia 10.3 DRD3 DRD2
12 internuclear ophthalmoplegia 10.2 JRK HECTD4
13 lumbosacral lipoma 10.2 LAX1 HECTD4
14 bladder lateral wall cancer 10.2 TTR JRK
15 shoulder impingement syndrome 10.2 HECTD4 GPX4
16 cyclothymic disorder 10.2 DRD4 DRD2
17 striatonigral degeneration 10.2 SLC6A3 DRD2 DRD1
18 focal dystonia 10.2 JRK DRD5 DRD2
19 endogenous depression 10.2 TRH GNRH1 CRH
20 cauda equina syndrome 10.1 LAX1 HECTD4
21 oppositional defiant disorder 10.1 SLC6A3 DRD4 DRD2
22 glomangiomatosis 10.1 LAX1 HECTD4
23 myositis ossificans 10.1 LAX1 HECTD4
24 focal hand dystonia 10.1 JRK DRD2
25 withdrawal disorder 10.0 DRD2 DRD1 CRH
26 generalized resistance to thyroid hormone 10.0 TRH PRL
27 adenohypophysitis 10.0 TRH PRL
28 marasmus 10.0 TTR SHBG
29 lactocele 10.0 TRH PRL
30 chromophobe adenoma 10.0 TRH PRL
31 chondromalacia 10.0 MRAP LAX1
32 palmoplantar keratoderma, punctate type iii 10.0 MRAP HECTD4
33 acidophil adenoma 10.0 TRH PRL
34 avoidant personality disorder 10.0 SLC6A3 DRD4 DRD3 DRD2
35 conduct disorder 10.0 SLC6A3 DRD5 DRD4 DRD2
36 heel spur 10.0 MRAP HECTD4
37 cerebrovascular benign neoplasm 10.0 TTR NES
38 acth-dependent cushing syndrome 9.9 PRL CRH
39 inhibited female orgasm 9.9 SHBG PRL
40 opioid abuse 9.9 DRD5 DRD3 DRD2 DRD1
41 plantar fasciitis 9.9 MRAP HECTD4
42 spondylolysis 9.9 TTR HECTD4
43 kohler's disease 9.9 MRAP HECTD4
44 dyslexia 9.9 SLC6A3 DRD4 DRD3 DRD2
45 eating disorder 9.9 SLC6A3 DRD3 DRD2 CRH
46 polyp of corpus uteri 9.9 PRL GNRH1
47 rete ovarii adenoma 9.9 PRL GNRH1
48 rete ovarii neoplasm 9.9 PRL GNRH1
49 bipolar i disorder 9.9 DRD4 DRD3 DRD2 DRD1
50 spinocerebellar degeneration 9.9 PRL CRH

Graphical network of the top 20 diseases related to Mixed Cerebral Palsy:

Diseases related to Mixed Cerebral Palsy

Symptoms & Phenotypes for Mixed Cerebral Palsy

MGI Mouse Phenotypes related to Mixed Cerebral Palsy:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 CRH DRD1 DRD2 DRD3 DRD4 DRD5
2 homeostasis/metabolism MP:0005376 9.97 CRH DRD1 DRD2 DRD3 DRD4 GNRH1
3 nervous system MP:0003631 9.73 CRH DRD1 DRD2 DRD3 DRD4 DRD5
4 renal/urinary system MP:0005367 9.17 CRH DRD2 DRD3 DRD5 GNRH1 TRH

Drugs & Therapeutics for Mixed Cerebral Palsy

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Comparison Of PIR Technique With Eccentric Isotonic Muscle Contraction on Hamstring Spasticity in CP Child Completed NCT03708757
2 Movement Impairment Characterization and Rehabilitation for Spastic/Dystonic Cerebral Palsy Using Robotic Haptic Feedback in Virtual Reality Not yet recruiting NCT03744884

Search NIH Clinical Center for Mixed Cerebral Palsy

Genetic Tests for Mixed Cerebral Palsy

Anatomical Context for Mixed Cerebral Palsy

MalaCards organs/tissues related to Mixed Cerebral Palsy:

Pituitary, Brain, Thyroid, Cortex, Breast, Adrenal Cortex

Publications for Mixed Cerebral Palsy

Articles related to Mixed Cerebral Palsy:

# Title Authors PMID Year
Cervical Myelopathy in a Child: A Rare Cause of Hypoventilation Syndrome Presenting with Type 2 Respiratory Failure. 61
29743771 2018
Combined therapy of orthopedic surgery after deep brain stimulation in cerebral palsy mixed type - a case report -. 61
22506201 2011
Acoustic-phonetic contrasts and intelligibility in the dysarthria associated with mixed cerebral palsy. 61
1573870 1992
Cerebral palsy: why we must plan for survival. 61
2148667 1990

Variations for Mixed Cerebral Palsy

Expression for Mixed Cerebral Palsy

Search GEO for disease gene expression data for Mixed Cerebral Palsy.

Pathways for Mixed Cerebral Palsy

Pathways related to Mixed Cerebral Palsy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.55 DRD5 DRD4 DRD3 DRD2 DRD1
Show member pathways
4 12.08 DRD5 DRD4 DRD3 DRD2 DRD1
Show member pathways
11.95 DRD5 DRD4 DRD2 DRD1
Show member pathways
11.76 SLC6A3 DRD2 DRD1
Show member pathways
11.66 DRD4 DRD3 DRD2
Show member pathways
10 10.75 SHBG GNRH1
11 10.6 DRD5 DRD3 DRD2 DRD1
Show member pathways

GO Terms for Mixed Cerebral Palsy

Cellular components related to Mixed Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 SLC6A3 SLC16A2 DRD5 DRD4 DRD3 DRD2
2 GABA-ergic synapse GO:0098982 9.54 DRD3 DRD2 DRD1
3 integral component of presynaptic membrane GO:0099056 9.5 SLC6A3 DRD2 DRD1
4 ciliary membrane GO:0060170 9.43 DRD5 DRD2 DRD1
5 integral component of postsynaptic membrane GO:0099055 9.33 SLC6A3 DRD2 DRD1
6 non-motile cilium GO:0097730 9.13 DRD5 DRD2 DRD1
7 dopaminergic synapse GO:0098691 8.8 SLC6A3 DRD3 DRD2

Biological processes related to Mixed Cerebral Palsy according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 TTR TRH PRL GNRH1 DRD5 DRD4
2 G protein-coupled receptor signaling pathway GO:0007186 10.22 TRH GNRH1 DRD5 DRD4 DRD3 DRD2
3 response to drug GO:0042493 10.05 SLC6A3 DRD3 DRD2 DRD1 CRH
4 locomotory behavior GO:0007626 9.91 SLC6A3 DRD3 DRD2 DRD1
5 cellular calcium ion homeostasis GO:0006874 9.89 DRD5 DRD4 DRD3
6 female pregnancy GO:0007565 9.87 PRL GNRH1 CRH
7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.87 DRD5 DRD3 DRD2 DRD1
8 visual learning GO:0008542 9.84 DRD3 DRD2 DRD1
9 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.83 DRD3 DRD2 DRD1
10 associative learning GO:0008306 9.83 DRD5 DRD2 DRD1 CRH
11 adult walking behavior GO:0007628 9.81 TRH DRD2 DRD1
12 negative regulation of blood pressure GO:0045776 9.8 DRD5 DRD3 DRD2
13 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.8 DRD5 DRD3 DRD2 DRD1
14 arachidonic acid secretion GO:0050482 9.79 DRD4 DRD3 DRD2
15 negative regulation of protein secretion GO:0050709 9.77 DRD4 DRD3 DRD2
16 negative regulation of voltage-gated calcium channel activity GO:1901386 9.76 DRD4 DRD3 DRD2
17 dopamine receptor signaling pathway GO:0007212 9.76 DRD4 DRD3 DRD2 DRD1
18 behavioral response to ethanol GO:0048149 9.75 DRD4 DRD3 DRD2
19 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.73 DRD5 DRD3 DRD1
20 behavioral response to cocaine GO:0048148 9.73 DRD4 DRD3 DRD2 DRD1
21 response to ethanol GO:0045471 9.73 TRH SLC6A3 GNRH1 DRD3 DRD2 CRH
22 response to corticosterone GO:0051412 9.72 TRH CRH
23 response to iron ion GO:0010039 9.72 SLC6A3 DRD2
24 negative regulation of cytosolic calcium ion concentration GO:0051481 9.72 DRD3 DRD2
25 regulation of dopamine metabolic process GO:0042053 9.72 SLC6A3 DRD4 DRD1
26 transmission of nerve impulse GO:0019226 9.71 DRD5 DRD1
27 long-term synaptic depression GO:0060292 9.71 DRD5 DRD1
28 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.71 DRD3 DRD2
29 positive regulation of renal sodium excretion GO:0035815 9.71 DRD3 DRD2
30 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.71 DRD4 DRD3 DRD2
31 prepulse inhibition GO:0060134 9.71 SLC6A3 DRD3 DRD2 DRD1
32 grooming behavior GO:0007625 9.7 DRD2 DRD1
33 G protein-coupled receptor internalization GO:0002031 9.7 DRD3 DRD2
34 striatum development GO:0021756 9.7 DRD2 DRD1
35 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.69 DRD4 DRD3
36 regulation of potassium ion transport GO:0043266 9.69 DRD3 DRD2
37 peristalsis GO:0030432 9.69 DRD2 DRD1
38 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.69 DRD3 DRD2 DRD1
39 adenohypophysis development GO:0021984 9.68 SLC6A3 DRD2
40 thyroid hormone transport GO:0070327 9.68 TTR SLC16A2
41 mating behavior GO:0007617 9.68 DRD5 DRD1
42 cellular response to catecholamine stimulus GO:0071870 9.68 DRD5 DRD1
43 cerebral cortex GABAergic interneuron migration GO:0021853 9.67 DRD2 DRD1
44 dopamine transport GO:0015872 9.67 SLC6A3 DRD1
45 dopamine metabolic process GO:0042417 9.67 DRD4 DRD3 DRD2 DRD1
46 negative regulation of dopamine receptor signaling pathway GO:0060160 9.66 DRD3 DRD2
47 regulation of neurotransmitter uptake GO:0051580 9.66 DRD3 DRD2
48 regulation of locomotion involved in locomotory behavior GO:0090325 9.65 DRD3 DRD2
49 response to histamine GO:0034776 9.65 DRD4 DRD3 DRD2
50 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.64 DRD4 DRD2

Molecular functions related to Mixed Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.67 SLC6A3 DRD4 DRD3 DRD2
2 hormone activity GO:0005179 9.65 TTR TRH PRL GNRH1 CRH
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.5 DRD4 DRD3 DRD2
4 adrenergic receptor activity GO:0004935 9.46 DRD5 DRD3 DRD2 DRD1
5 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.4 DRD5 DRD1
6 dopamine neurotransmitter receptor activity GO:0004952 9.35 DRD5 DRD4 DRD3 DRD2 DRD1
7 dopamine binding GO:0035240 9.1 SLC6A3 DRD5 DRD4 DRD3 DRD2 DRD1

Sources for Mixed Cerebral Palsy

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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