MCID: MXD010
MIFTS: 22

Mixed Epithelial Stromal Tumour

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Mixed Epithelial Stromal Tumour

MalaCards integrated aliases for Mixed Epithelial Stromal Tumour:

Name: Mixed Epithelial Stromal Tumour 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5088
NCIt 50 C37265
UMLS 72 C1334602

Summaries for Mixed Epithelial Stromal Tumour

MalaCards based summary : Mixed Epithelial Stromal Tumour is related to cystic nephroma and toxicity or absent response to clozapine. An important gene associated with Mixed Epithelial Stromal Tumour is SULT2A1 (Sulfotransferase Family 2A Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include kidney.

Wikipedia : 75 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

Related Diseases for Mixed Epithelial Stromal Tumour

Diseases related to Mixed Epithelial Stromal Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 cystic nephroma 11.5
2 toxicity or absent response to clozapine 9.9 CYP1A2 COMT
3 tardive dyskinesia 9.9 CYP1A2 COMT
4 mammographic density 9.8 CYP1B1 COMT
5 mycetoma 9.7 CYP1B1 COMT
6 breast disease 9.7 CYP1B1 COMT
7 kleptomania 9.6 CYP3A4 CYP1A2
8 clopidogrel resistance 9.5 CYP3A4 CYP1A2
9 hepatocellular adenoma 9.4 CYP3A4 CYP1A2
10 acetaminophen metabolism 9.3 CYP3A4 CYP1A2
11 anxiety 9.1 CYP3A4 CYP1A2 COMT

Graphical network of the top 20 diseases related to Mixed Epithelial Stromal Tumour:



Diseases related to Mixed Epithelial Stromal Tumour

Symptoms & Phenotypes for Mixed Epithelial Stromal Tumour

Drugs & Therapeutics for Mixed Epithelial Stromal Tumour

Search Clinical Trials , NIH Clinical Center for Mixed Epithelial Stromal Tumour

Genetic Tests for Mixed Epithelial Stromal Tumour

Anatomical Context for Mixed Epithelial Stromal Tumour

MalaCards organs/tissues related to Mixed Epithelial Stromal Tumour:

41
Kidney

Publications for Mixed Epithelial Stromal Tumour

Articles related to Mixed Epithelial Stromal Tumour:

# Title Authors PMID Year
1
Renal oncocytosis: a clinicopathological and cytogenetic study of 42 tumours occurring in 11 patients. 38
27020208 2016
2
Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity. 38
20193076 2010
3
Low grade epithelial stromal tumour of the seminal vesicle. 38
18811925 2008
4
Aggressive mixed epithelial-stromal tumour of the kidney treated with chemotherapy and radiotherapy. 38
15581546 2004

Variations for Mixed Epithelial Stromal Tumour

Expression for Mixed Epithelial Stromal Tumour

Search GEO for disease gene expression data for Mixed Epithelial Stromal Tumour.

Pathways for Mixed Epithelial Stromal Tumour

Pathways related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 SULT2A1 CYP3A4 CYP1B1 CYP1A2 COMT
2
Show member pathways
12.49 SULT2A1 CYP3A4 CYP1B1 CYP1A2
3
Show member pathways
11.7 CYP3A4 CYP1A2
4
Show member pathways
11.63 CYP3A4 CYP1B1 CYP1A2
5
Show member pathways
11.51 SULT2A1 CYP3A4 CYP1A2
6 11.48 SULT2A1 CYP3A4
7
Show member pathways
11.38 CYP3A4 CYP1B1 CYP1A2 COMT
8
Show member pathways
11.35 CYP3A4 CYP1A2 COMT
9 11.32 CYP3A4 CYP1A2
10 11.29 CYP1B1 CYP1A2
11 11.29 CYP1B1 CYP1A2
12
Show member pathways
11.19 SULT2A1 CYP3A4 CYP1A2 COMT
13 11.17 CYP1B1 CYP1A2
14 11.14 CYP3A4 CYP1A2
15 11.09 SULT2A1 CYP3A4
16
Show member pathways
11.04 CYP3A4 CYP1B1 CYP1A2
17
Show member pathways
10.99 CYP3A4 CYP1A2
18 10.95 CYP3A4 CYP1A2
19 10.92 CYP3A4 CYP1A2
20
Show member pathways
10.85 SULT2A1 CYP3A4 CYP1B1 CYP1A2
21 10.83 SULT2A1 CYP3A4
22 10.77 SULT2A1 CYP3A4
23
Show member pathways
10.71 CYP3A4 CYP1A2
24 10.61 CYP1B1 CYP1A2
25
Show member pathways
10.55 SULT2A1 CYP3A4 CYP1B1 CYP1A2 COMT
26
Show member pathways
10.52 CYP1B1 CYP1A2

GO Terms for Mixed Epithelial Stromal Tumour

Cellular components related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.56 MEST CYP3A4 CYP1B1 CYP1A2
2 endoplasmic reticulum membrane GO:0005789 9.46 MEST CYP3A4 CYP1B1 CYP1A2
3 intracellular membrane-bounded organelle GO:0043231 9.26 CYP3A4 CYP1B1 CYP1A2 COMT
4 organelle membrane GO:0031090 8.8 CYP3A4 CYP1B1 CYP1A2

Biological processes related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.75 CYP3A4 CYP1B1 CYP1A2
2 lipid metabolic process GO:0006629 9.73 SULT2A1 CYP3A4 CYP1A2
3 response to organic cyclic compound GO:0014070 9.57 CYP1A2 COMT
4 exogenous drug catabolic process GO:0042738 9.55 CYP3A4 CYP1A2
5 drug metabolic process GO:0017144 9.54 CYP3A4 CYP1A2
6 xenobiotic metabolic process GO:0006805 9.54 CYP3A4 CYP1B1 CYP1A2
7 long-chain fatty acid biosynthetic process GO:0042759 9.52 CYP3A4 CYP1A2
8 epoxygenase P450 pathway GO:0019373 9.51 CYP1B1 CYP1A2
9 estrogen metabolic process GO:0008210 9.49 CYP1B1 COMT
10 omega-hydroxylase P450 pathway GO:0097267 9.48 CYP1B1 CYP1A2
11 toxin metabolic process GO:0009404 9.46 CYP1B1 CYP1A2
12 oxidative demethylation GO:0070989 9.43 CYP3A4 CYP1A2
13 heterocycle metabolic process GO:0046483 9.4 CYP3A4 CYP1A2
14 monoterpenoid metabolic process GO:0016098 9.32 CYP3A4 CYP1A2
15 drug catabolic process GO:0042737 9.26 CYP3A4 CYP1A2
16 steroid catabolic process GO:0006706 9.16 CYP3A4 CYP1A2
17 cellular aromatic compound metabolic process GO:0006725 8.96 CYP1B1 CYP1A2
18 steroid metabolic process GO:0008202 8.92 SULT2A1 CYP3A4 CYP1B1 CYP1A2

Molecular functions related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.63 CYP3A4 CYP1B1 CYP1A2
2 iron ion binding GO:0005506 9.54 CYP3A4 CYP1B1 CYP1A2
3 heme binding GO:0020037 9.5 CYP3A4 CYP1B1 CYP1A2
4 oxygen binding GO:0019825 9.43 CYP3A4 CYP1B1
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP3A4 CYP1B1 CYP1A2
6 aromatase activity GO:0070330 9.4 CYP1B1 CYP1A2
7 caffeine oxidase activity GO:0034875 9.16 CYP3A4 CYP1A2
8 monooxygenase activity GO:0004497 9.13 CYP3A4 CYP1B1 CYP1A2
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP3A4 CYP1B1 CYP1A2

Sources for Mixed Epithelial Stromal Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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