MCID: MXD010
MIFTS: 24

Mixed Epithelial Stromal Tumour

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Mixed Epithelial Stromal Tumour

MalaCards integrated aliases for Mixed Epithelial Stromal Tumour:

Name: Mixed Epithelial Stromal Tumour 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5088
NCIt 49 C37265
UMLS 71 C1334602

Summaries for Mixed Epithelial Stromal Tumour

MalaCards based summary : Mixed Epithelial Stromal Tumour is related to adult cystic nephroma and nephroma. An important gene associated with Mixed Epithelial Stromal Tumour is SULT2A1 (Sulfotransferase Family 2A Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include kidney.

Wikipedia : 74 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

Related Diseases for Mixed Epithelial Stromal Tumour

Diseases related to Mixed Epithelial Stromal Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 adult cystic nephroma 32.6 MME MEST
2 nephroma 10.2 MME MEST
3 mammographic density 10.1 CYP1B1 COMT
4 tardive dyskinesia 10.1 CYP1A2 COMT
5 mycetoma 10.1 CYP1B1 COMT
6 angiodysplasia of intestine 10.0 CYP3A4 CYP1A2
7 hypertrophy of tongue papillae 10.0 CYP3A4 CYP1A2
8 clopidogrel resistance 10.0 CYP3A4 CYP1A2
9 acetaminophen metabolism 9.9 CYP3A4 CYP1A2
10 neonatal abstinence syndrome 9.9 CYP3A4 COMT
11 nephrogenic adenoma of urinary bladder 9.8 MME KRT7
12 wolffian duct adenoma 9.8 MME KRT7
13 subareolar duct papillomatosis 9.8 MME KRT7
14 nipple benign neoplasm 9.8 MME KRT7
15 pancreatic serous cystadenocarcinoma 9.8 MME KRT7
16 female urethral cancer 9.8 MME KRT7
17 epididymal neoplasm 9.8 MME KRT7
18 clear cell papillary renal cell carcinoma 9.8 MME KRT7
19 chromophil adenoma of the kidney 9.8 MME KRT7
20 uterus perivascular epithelioid cell tumor 9.8 MME KRT7
21 clear cell hidradenoma 9.8 MME KRT7
22 hidradenoma 9.8 MME KRT7
23 wolffian duct adenocarcinoma 9.8 MME KRT7
24 pulmonary artery leiomyosarcoma 9.8 MME KRT7
25 balloon cell malignant melanoma 9.8 MME KRT7
26 nephrogenic adenoma of the urethra 9.8 MME KRT7
27 pancreatic mucinous cystadenoma 9.8 MME KRT7
28 cystadenoma 9.8 MME KRT7
29 cystadenofibroma 9.8 MME KRT7
30 adenofibroma 9.8 MME KRT7
31 eccrine papillary adenocarcinoma 9.8 MME KRT7
32 cutaneous adenocystic carcinoma 9.8 MME KRT7
33 mucinous tubular and spindle renal cell carcinoma 9.8 MME KRT7
34 renal adenoma 9.8 MME KRT7
35 nasal cavity olfactory neuroblastoma 9.8 MME KRT7
36 ovarian sex-cord stromal tumor 9.8 MME KRT7
37 adenomyosis 9.8 MME COMT
38 bladder lateral wall cancer 9.8 MME KRT7
39 epididymis adenocarcinoma 9.8 MME KRT7
40 epididymis cancer 9.8 MME KRT7
41 urethral benign neoplasm 9.8 MME KRT7
42 cervical adenoma malignum 9.8 MME KRT7
43 breast osteosarcoma 9.8 MME KRT7
44 squamous papillomatosis 9.8 MME KRT7
45 bladder clear cell adenocarcinoma 9.7 MME KRT7
46 intraductal breast benign neoplasm 9.7 MME KRT7
47 breast benign neoplasm 9.7 MME KRT7
48 central epithelioid sarcoma 9.7 MME KRT7
49 vulvar proximal-type epithelioid sarcoma 9.7 MME KRT7
50 adenomyoma 9.7 MME KRT7

Graphical network of the top 20 diseases related to Mixed Epithelial Stromal Tumour:



Diseases related to Mixed Epithelial Stromal Tumour

Symptoms & Phenotypes for Mixed Epithelial Stromal Tumour

Drugs & Therapeutics for Mixed Epithelial Stromal Tumour

Search Clinical Trials , NIH Clinical Center for Mixed Epithelial Stromal Tumour

Genetic Tests for Mixed Epithelial Stromal Tumour

Anatomical Context for Mixed Epithelial Stromal Tumour

MalaCards organs/tissues related to Mixed Epithelial Stromal Tumour:

40
Kidney

Publications for Mixed Epithelial Stromal Tumour

Articles related to Mixed Epithelial Stromal Tumour:

# Title Authors PMID Year
1
Metastasis in mixed epithelial stromal tumour of the kidney: a rare presentation. 61
31570342 2019
2
Renal oncocytosis: a clinicopathological and cytogenetic study of 42 tumours occurring in 11 patients. 61
27020208 2016
3
Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity. 61
20193076 2010
4
Low grade epithelial stromal tumour of the seminal vesicle. 61
18811925 2008
5
Aggressive mixed epithelial-stromal tumour of the kidney treated with chemotherapy and radiotherapy. 61
15581546 2004

Variations for Mixed Epithelial Stromal Tumour

Expression for Mixed Epithelial Stromal Tumour

Search GEO for disease gene expression data for Mixed Epithelial Stromal Tumour.

Pathways for Mixed Epithelial Stromal Tumour

Pathways related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 SULT2A1 CYP3A4 CYP1B1 CYP1A2 COMT
2
Show member pathways
12.57 SULT2A1 CYP3A4 CYP1B1 CYP1A2
3
Show member pathways
11.65 CYP3A4 CYP1A2 COMT
4
Show member pathways
11.57 CYP3A4 CYP1B1 CYP1A2
5
Show member pathways
11.48 SULT2A1 CYP3A4 CYP1A2
6
Show member pathways
11.38 CYP3A4 CYP1B1 CYP1A2 COMT
7
Show member pathways
11.35 CYP3A4 CYP1B1
8
Show member pathways
11.35 CYP3A4 CYP1A2 COMT
9 11.34 CYP3A4 CYP1A2
10 11.3 CYP1B1 CYP1A2
11 11.3 CYP1B1 CYP1A2
12
Show member pathways
11.19 SULT2A1 CYP3A4 CYP1A2 COMT
13 11.18 CYP1B1 CYP1A2
14 11.15 CYP3A4 CYP1A2
15
Show member pathways
11.13 CYP3A4 CYP1A2
16 11.1 SULT2A1 CYP3A4
17
Show member pathways
11.04 CYP3A4 CYP1B1 CYP1A2
18 10.96 CYP3A4 CYP1A2
19
Show member pathways
10.96 CYP3A4 CYP1A2
20 10.93 CYP3A4 CYP1A2
21
Show member pathways
10.85 SULT2A1 CYP3A4 CYP1B1 CYP1A2
22 10.84 SULT2A1 CYP3A4
23 10.78 SULT2A1 CYP3A4
24
Show member pathways
10.73 CYP3A4 CYP1A2
25 10.62 CYP1B1 CYP1A2
26
Show member pathways
10.55 SULT2A1 CYP3A4 CYP1B1 CYP1A2 COMT
27
Show member pathways
10.54 CYP1B1 CYP1A2

GO Terms for Mixed Epithelial Stromal Tumour

Cellular components related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.46 MEST CYP3A4 CYP1B1 CYP1A2
2 intracellular membrane-bounded organelle GO:0043231 9.26 CYP3A4 CYP1B1 CYP1A2 COMT
3 organelle membrane GO:0031090 8.8 CYP3A4 CYP1B1 CYP1A2

Biological processes related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.83 SULT2A1 CYP3A4 CYP1B1 CYP1A2
2 fatty acid metabolic process GO:0006631 9.72 CYP3A4 CYP1B1 CYP1A2
3 xenobiotic metabolic process GO:0006805 9.63 CYP3A4 CYP1B1 CYP1A2
4 arachidonic acid metabolic process GO:0019369 9.58 CYP1B1 CYP1A2
5 long-chain fatty acid biosynthetic process GO:0042759 9.58 CYP3A4 CYP1A2
6 exogenous drug catabolic process GO:0042738 9.57 CYP3A4 CYP1A2
7 drug metabolic process GO:0017144 9.56 CYP3A4 CYP1A2
8 epoxygenase P450 pathway GO:0019373 9.54 CYP1B1 CYP1A2
9 oxidative demethylation GO:0070989 9.51 CYP3A4 CYP1A2
10 omega-hydroxylase P450 pathway GO:0097267 9.49 CYP1B1 CYP1A2
11 toxin metabolic process GO:0009404 9.48 CYP1B1 CYP1A2
12 heterocycle metabolic process GO:0046483 9.43 CYP3A4 CYP1A2
13 drug catabolic process GO:0042737 9.4 CYP3A4 CYP1A2
14 monoterpenoid metabolic process GO:0016098 9.37 CYP3A4 CYP1A2
15 retinol metabolic process GO:0042572 9.33 CYP3A4 CYP1B1 CYP1A2
16 cellular aromatic compound metabolic process GO:0006725 9.32 CYP1B1 CYP1A2
17 steroid catabolic process GO:0006706 9.26 CYP3A4 CYP1A2
18 steroid metabolic process GO:0008202 9.26 SULT2A1 CYP3A4 CYP1B1 CYP1A2
19 estrogen metabolic process GO:0008210 8.92 CYP3A4 CYP1B1 CYP1A2 COMT

Molecular functions related to Mixed Epithelial Stromal Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.63 CYP3A4 CYP1B1 CYP1A2
2 iron ion binding GO:0005506 9.61 CYP3A4 CYP1B1 CYP1A2
3 monooxygenase activity GO:0004497 9.58 CYP3A4 CYP1B1 CYP1A2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.54 CYP3A4 CYP1B1 CYP1A2
5 oxygen binding GO:0019825 9.48 CYP3A4 CYP1B1
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.33 CYP3A4 CYP1B1 CYP1A2
7 estrogen 2-hydroxylase activity GO:0101021 9.32 CYP3A4 CYP1A2
8 caffeine oxidase activity GO:0034875 9.26 CYP3A4 CYP1A2
9 aromatase activity GO:0070330 9.13 CYP3A4 CYP1B1 CYP1A2
10 estrogen 16-alpha-hydroxylase activity GO:0101020 8.8 CYP3A4 CYP1B1 CYP1A2

Sources for Mixed Epithelial Stromal Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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