MCID: MXD024
MIFTS: 26

Mixed Epithelial Tumor of Ovary

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Mixed Epithelial Tumor of Ovary

MalaCards integrated aliases for Mixed Epithelial Tumor of Ovary:

Name: Mixed Epithelial Tumor of Ovary 12 15 71
Ovarian Mixed Epithelial Tumor 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:6211
NCIt 49 C4508
UMLS 71 C0346166

Summaries for Mixed Epithelial Tumor of Ovary

Disease Ontology : 12 An ovarian benign neoplasm that is biphasic and has material basis in epithelial and mesenchymal elements.

MalaCards based summary : Mixed Epithelial Tumor of Ovary, also known as ovarian mixed epithelial tumor, is related to linitis plastica and fallopian tube endometrioid adenocarcinoma. An important gene associated with Mixed Epithelial Tumor of Ovary is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways are PEDF Induced Signaling and PI3K-Akt signaling pathway. The drugs Cyclophosphamide and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include ovary, myeloid and bone marrow, and related phenotype is integument.

Related Diseases for Mixed Epithelial Tumor of Ovary

Diseases related to Mixed Epithelial Tumor of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 linitis plastica 10.0 ERBB2 APOLD1
2 fallopian tube endometrioid adenocarcinoma 10.0 ERBB2 APOLD1
3 rectum adenocarcinoma 10.0 ERBB2 APOLD1
4 iritis 9.9 TNFRSF1B EPO
5 ascending colon cancer 9.8 CSF3 APOLD1
6 pneumocystosis 9.7 TNFRSF1B CSF3
7 pyoderma 9.7 TNFRSF1B CSF3
8 female breast cancer 9.7 ERBB2 CSF3
9 acute radiation syndrome 9.7 EPO CSF3
10 retinitis pigmentosa and erythrocytic microcytosis 9.7 EPO CSF3
11 refractory anemia 9.7 EPO CSF3
12 hair disease 9.7 ERBB2 CSF3
13 poems syndrome 9.7 EPO CSF3
14 hypersplenism 9.7 EPO CSF3
15 acquired immunodeficiency syndrome 9.6 TNFRSF1B EPO
16 hemoglobinuria 9.6 EPO CSF3
17 blood coagulation disease 9.6 EPO CSF3
18 fallopian tube serous adenocarcinoma 9.6 TNFRSF1B EPO APOLD1
19 aspergillosis 9.6 TNFRSF1B CSF3
20 pulmonary edema 9.6 EPO CSF3
21 sickle cell anemia 9.6 EPO CSF3
22 thrombocytosis 9.5 EPO CSF3
23 bone marrow cancer 9.5 EPO CSF3
24 blood platelet disease 9.4 EPO CSF3
25 exanthem 9.4 TNFRSF1B ERBB2 CSF3
26 pancytopenia 9.3 EPO CSF3
27 miliary tuberculosis 9.3 TNFRSF1B EPO CSF3
28 myeloma, multiple 9.2 ERBB2 EPO CSF3
29 leukemia, chronic myeloid 9.2 ERBB2 EPO CSF3
30 thrombocytopenia 9.2 ERBB2 EPO CSF3
31 polycythemia vera 9.2 EPO CSF3
32 leukemia, acute myeloid 9.1 ERBB2 EPO CSF3
33 myelodysplastic syndrome 8.9 TNFRSF1B ERBB2 EPO CSF3
34 ovarian clear cell cystadenocarcinoma 8.6 TNFRSF1B ERBB2 EPO CSF3 APOLD1
35 ovarian clear cell malignant adenofibroma 8.6 TNFRSF1B ERBB2 EPO CSF3 APOLD1
36 fallopian tube transitional cell carcinoma 8.6 TNFRSF1B ERBB2 EPO CSF3 APOLD1
37 fallopian tube mucinous adenocarcinoma 8.6 TNFRSF1B ERBB2 EPO CSF3 APOLD1

Graphical network of the top 20 diseases related to Mixed Epithelial Tumor of Ovary:



Diseases related to Mixed Epithelial Tumor of Ovary

Symptoms & Phenotypes for Mixed Epithelial Tumor of Ovary

MGI Mouse Phenotypes related to Mixed Epithelial Tumor of Ovary:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 CSF3 EPO ERBB2 TNFRSF1B

Drugs & Therapeutics for Mixed Epithelial Tumor of Ovary

Drugs for Mixed Epithelial Tumor of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
3
Lenograstim Approved, Investigational Phase 2 135968-09-1
4
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
7
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
8 Immunosuppressive Agents Phase 2
9 Alkylating Agents Phase 2
10 topoisomerase I inhibitors Phase 2
11 Topoisomerase Inhibitors Phase 2
12 Antimitotic Agents Phase 2
13 Immunologic Factors Phase 2
14 Antirheumatic Agents Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Adjuvants, Immunologic Phase 2
17
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
18 Anti-Bacterial Agents Phase 1
19 Antibiotics, Antitubercular Phase 1
20
Liposomal doxorubicin Phase 1 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Trial Using Multiple Cycles of High Dose Sequential Carboplatin, Paclitaxel and Topotecan With Peripheral Blood Stem Cell (PBSC) Support as Initial Chemotherapy in Patients With Optimally Debulked Stage III Ovarian and Primary Peritoneal Carcinoma Terminated NCT00004221 Phase 2 Carboplatin;Cyclophosphamide;Paclitaxel;Topotecan Hydrochloride
2 A Phase I Study of VTX-2337 in Combination With Pegylated Liposomal Doxorubicin (PLD; NSC# 712227) or in Combination With Weekly Pactilaxel (NSC #673089) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer Completed NCT01294293 Phase 1 TLR8 Agonist VTX-2337;Pegylated Liposomal Doxorubicin Hydrochloride;Paclitaxel

Search NIH Clinical Center for Mixed Epithelial Tumor of Ovary

Genetic Tests for Mixed Epithelial Tumor of Ovary

Anatomical Context for Mixed Epithelial Tumor of Ovary

MalaCards organs/tissues related to Mixed Epithelial Tumor of Ovary:

40
Ovary, Myeloid, Bone Marrow, Bone, Colon, Breast

Publications for Mixed Epithelial Tumor of Ovary

Variations for Mixed Epithelial Tumor of Ovary

Expression for Mixed Epithelial Tumor of Ovary

Search GEO for disease gene expression data for Mixed Epithelial Tumor of Ovary.

Pathways for Mixed Epithelial Tumor of Ovary

Pathways related to Mixed Epithelial Tumor of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 TNFRSF1B ERBB2 EPO CSF3
2
Show member pathways
12.33 ERBB2 EPO CSF3
3 11.43 EPO CSF3
4 11.29 ERBB2 EPO
5 11.15 EPO CSF3
6 10.65 TNFRSF1B CSF3
7 10.3 EPO CSF3

GO Terms for Mixed Epithelial Tumor of Ovary

Biological processes related to Mixed Epithelial Tumor of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.33 ERBB2 EPO CSF3
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 EPO CSF3
3 cellular response to growth factor stimulus GO:0071363 8.96 TNFRSF1B ERBB2
4 negative regulation of neuron death GO:1901215 8.8 TNFRSF1B EPO CSF3

Sources for Mixed Epithelial Tumor of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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