MCID: MXD042
MIFTS: 22

Mixed Fibrolamellar Hepatocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Mixed Fibrolamellar Hepatocellular Carcinoma

MalaCards integrated aliases for Mixed Fibrolamellar Hepatocellular Carcinoma:

Name: Mixed Fibrolamellar Hepatocellular Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080182

Summaries for Mixed Fibrolamellar Hepatocellular Carcinoma

Disease Ontology : 12 A fibrolamellar carcinoma that is characteirzed by the presence of both pure fibrolamellar hepatocellular carcinoma and and conventional hepatocellular carcinoma components.

MalaCards based summary : Mixed Fibrolamellar Hepatocellular Carcinoma is related to fibrolamellar carcinoma and oncocytic breast carcinoma. An important gene associated with Mixed Fibrolamellar Hepatocellular Carcinoma is DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1), and among its related pathways/superpathways are Cytoskeletal Signaling and Tight junction. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mixed Fibrolamellar Hepatocellular Carcinoma

Diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 fibrolamellar carcinoma 30.0 PRKACA KRT7 KRT19 DNAJB1
2 oncocytic breast carcinoma 10.2 KRT7 ERBB2
3 vulva adenocarcinoma 10.2 KRT7 ERBB2
4 vulval paget's disease 10.2 KRT7 ERBB2
5 breast metaplastic carcinoma 10.2 KRT7 ERBB2
6 breast mucinous carcinoma 10.2 KRT7 ERBB2
7 gastric diffuse adenocarcinoma 10.2 KRT7 ERBB2
8 hepatocellular carcinoma 10.2
9 linitis plastica 10.2 KRT7 ERBB2
10 esophageal adenosquamous carcinoma 10.1 KRT7 ERBB2
11 bladder lateral wall cancer 10.1 KRT7 ERBB2
12 breast osteosarcoma 10.1 KRT7 ERBB2
13 apocrine sweat gland neoplasm 10.1 KRT7 ERBB2
14 breast neuroendocrine neoplasm 10.1 KRT7 ERBB2
15 intraductal breast benign neoplasm 10.1 KRT7 ERBB2
16 cribriform carcinoma 10.1 KRT7 ERBB2
17 bladder adenocarcinoma 10.1 KRT7 ERBB2
18 proliferating trichilemmal cyst 10.1 KRT7 KRT19
19 renal pelvis adenocarcinoma 10.1 KRT7 KRT19
20 intrahepatic gall duct cancer 10.1 KRT7 KRT19
21 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT19
22 anal canal adenocarcinoma 10.1 KRT7 KRT19
23 squamous cell bile duct carcinoma 10.1 KRT7 KRT19
24 lacrimal gland carcinoma 10.1 RASSF1 KRT7
25 intraductal papilloma 10.1 KRT7 ERBB2
26 pericardium cancer 10.1 KRT7 KRT19
27 pulmonary artery leiomyosarcoma 10.1 KRT7 KRT19
28 eccrine sweat gland cancer 10.1 KRT7 KRT19
29 hidrocystoma 10.1 KRT7 KRT19
30 eccrine papillary adenocarcinoma 10.1 KRT7 KRT19
31 ovarian germ cell teratoma 10.1 KRT7 KRT19
32 eccrine acrospiroma 10.1 KRT7 KRT19
33 eccrine sweat gland neoplasm 10.1 KRT7 KRT19
34 sarcomatous intrahepatic cholangiocarcinoma 10.1 KRT7 KRT19
35 cutaneous adenocystic carcinoma 10.1 KRT7 KRT19
36 vulvar disease 10.1 KRT7 ERBB2
37 clear cell basal cell carcinoma 10.1 KRT7 KRT19
38 nasal cavity olfactory neuroblastoma 10.0 KRT7 KRT19
39 adenoid squamous cell carcinoma 10.0 KRT7 KRT19
40 uterus leiomyosarcoma 10.0 KRT7 KRT19
41 bile duct cysts 10.0 KRT7 KRT19
42 uterine corpus sarcoma 10.0 KRT7 KRT19
43 female reproductive endometrioid cancer 10.0 KRT7 ERBB2
44 tall cell variant papillary carcinoma 10.0 TERT KRT19
45 cervical adenocarcinoma 10.0 RASSF1 KRT7 ERBB2
46 intrahepatic bile duct adenoma 10.0 KRT7 KRT19
47 klatskin's tumor 10.0 KRT7 KRT19
48 suppurative thyroiditis 10.0 KRT7 KRT19
49 ovarian germ cell cancer 10.0 KRT7 KRT19
50 papilloma 10.0 RASSF1 KRT7 ERBB2

Graphical network of the top 20 diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma:



Diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma

Symptoms & Phenotypes for Mixed Fibrolamellar Hepatocellular Carcinoma

GenomeRNAi Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-135 9.1 ARG1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.1 ARG1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.1 ERBB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 9.1 ERBB2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.1 ARG1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-99 9.1 ARG1

MGI Mouse Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.43 ERBB2 KRT19 PRKACA RASSF1 TACC2 TERT
2 normal MP:0002873 9.17 ARG1 DNAJB1 ERBB2 KRT19 RASSF1 TACC2

Drugs & Therapeutics for Mixed Fibrolamellar Hepatocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Mixed Fibrolamellar Hepatocellular Carcinoma

Genetic Tests for Mixed Fibrolamellar Hepatocellular Carcinoma

Anatomical Context for Mixed Fibrolamellar Hepatocellular Carcinoma

Publications for Mixed Fibrolamellar Hepatocellular Carcinoma

Articles related to Mixed Fibrolamellar Hepatocellular Carcinoma:

# Title Authors PMID Year
1
A genomic case study of mixed fibrolamellar hepatocellular carcinoma. 61
27029710 2016
2
Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases. 61
26017653 2015
3
Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection. 61
22415897 2012

Variations for Mixed Fibrolamellar Hepatocellular Carcinoma

Expression for Mixed Fibrolamellar Hepatocellular Carcinoma

Search GEO for disease gene expression data for Mixed Fibrolamellar Hepatocellular Carcinoma.

Pathways for Mixed Fibrolamellar Hepatocellular Carcinoma

Pathways related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 MUC1 KRT7 KRT19 CLTC
2 11.36 PRKACA PRKAA1 ERBB2

GO Terms for Mixed Fibrolamellar Hepatocellular Carcinoma

Cellular components related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10 TERT TACC2 RASSF1 PRKACA PRKAA1 MUC1
2 cytosol GO:0005829 9.85 TERT TACC2 PRKACA PRKAA1 KRT7 KRT19
3 cytoplasm GO:0005737 9.4 TERT TACC2 RASSF1 PRKACA PRKAA1 MUC1
4 nucleotide-activated protein kinase complex GO:0031588 8.96 PRKACA PRKAA1

Biological processes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cadmium ion GO:0046686 8.96 TERT ARG1
2 cellular response to glucagon stimulus GO:0071377 8.62 PRKACA ARG1

Molecular functions related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear hormone receptor binding GO:0035257 9.16 TACC2 BCAS3
2 AMP-activated protein kinase activity GO:0004679 8.96 PRKACA PRKAA1
3 cAMP-dependent protein kinase activity GO:0004691 8.62 PRKACA PRKAA1

Sources for Mixed Fibrolamellar Hepatocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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