Mixed Fibrolamellar Hepatocellular Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mixed Fibrolamellar Hepatocellular Carcinoma

MalaCards integrated aliases for Mixed Fibrolamellar Hepatocellular Carcinoma:

Name: Mixed Fibrolamellar Hepatocellular Carcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080182

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Summaries for Mixed Fibrolamellar Hepatocellular Carcinoma

Disease Ontology : ¹² A fibrolamellar carcinoma that is characteirzed by the presence of both pure fibrolamellar hepatocellular carcinoma and and conventional hepatocellular carcinoma components.

MalaCards based summary : Mixed Fibrolamellar Hepatocellular Carcinoma is related to fibrolamellar carcinoma and oncocytic breast carcinoma. An important gene associated with Mixed Fibrolamellar Hepatocellular Carcinoma is DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1), and among its related pathways/superpathways are Cytoskeletal Signaling and Tight junction. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Mixed Fibrolamellar Hepatocellular Carcinoma

Diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)

#	Related Disease	Score	Top Affiliating Genes
1	fibrolamellar carcinoma	30.0	PRKACA KRT7 KRT19 DNAJB1
2	oncocytic breast carcinoma	10.2	KRT7 ERBB2
3	vulva adenocarcinoma	10.2	KRT7 ERBB2
4	vulval paget's disease	10.2	KRT7 ERBB2
5	breast metaplastic carcinoma	10.2	KRT7 ERBB2
6	breast mucinous carcinoma	10.2	KRT7 ERBB2
7	gastric diffuse adenocarcinoma	10.2	KRT7 ERBB2
8	hepatocellular carcinoma	10.2
9	linitis plastica	10.2	KRT7 ERBB2
10	esophageal adenosquamous carcinoma	10.1	KRT7 ERBB2
11	bladder lateral wall cancer	10.1	KRT7 ERBB2
12	breast osteosarcoma	10.1	KRT7 ERBB2
13	apocrine sweat gland neoplasm	10.1	KRT7 ERBB2
14	breast neuroendocrine neoplasm	10.1	KRT7 ERBB2
15	intraductal breast benign neoplasm	10.1	KRT7 ERBB2
16	cribriform carcinoma	10.1	KRT7 ERBB2
17	bladder adenocarcinoma	10.1	KRT7 ERBB2
18	proliferating trichilemmal cyst	10.1	KRT7 KRT19
19	renal pelvis adenocarcinoma	10.1	KRT7 KRT19
20	intrahepatic gall duct cancer	10.1	KRT7 KRT19
21	vulvar apocrine adenocarcinoma	10.1	KRT7 KRT19
22	anal canal adenocarcinoma	10.1	KRT7 KRT19
23	squamous cell bile duct carcinoma	10.1	KRT7 KRT19
24	lacrimal gland carcinoma	10.1	RASSF1 KRT7
25	intraductal papilloma	10.1	KRT7 ERBB2
26	pericardium cancer	10.1	KRT7 KRT19
27	pulmonary artery leiomyosarcoma	10.1	KRT7 KRT19
28	eccrine sweat gland cancer	10.1	KRT7 KRT19
29	hidrocystoma	10.1	KRT7 KRT19
30	eccrine papillary adenocarcinoma	10.1	KRT7 KRT19
31	ovarian germ cell teratoma	10.1	KRT7 KRT19
32	eccrine acrospiroma	10.1	KRT7 KRT19
33	eccrine sweat gland neoplasm	10.1	KRT7 KRT19
34	sarcomatous intrahepatic cholangiocarcinoma	10.1	KRT7 KRT19
35	cutaneous adenocystic carcinoma	10.1	KRT7 KRT19
36	vulvar disease	10.1	KRT7 ERBB2
37	clear cell basal cell carcinoma	10.1	KRT7 KRT19
38	nasal cavity olfactory neuroblastoma	10.0	KRT7 KRT19
39	adenoid squamous cell carcinoma	10.0	KRT7 KRT19
40	uterus leiomyosarcoma	10.0	KRT7 KRT19
41	bile duct cysts	10.0	KRT7 KRT19
42	uterine corpus sarcoma	10.0	KRT7 KRT19
43	female reproductive endometrioid cancer	10.0	KRT7 ERBB2
44	tall cell variant papillary carcinoma	10.0	TERT KRT19
45	cervical adenocarcinoma	10.0	RASSF1 KRT7 ERBB2
46	intrahepatic bile duct adenoma	10.0	KRT7 KRT19
47	klatskin's tumor	10.0	KRT7 KRT19
48	suppurative thyroiditis	10.0	KRT7 KRT19
49	ovarian germ cell cancer	10.0	KRT7 KRT19
50	papilloma	10.0	RASSF1 KRT7 ERBB2

Graphical network of the top 20 diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma:

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Symptoms & Phenotypes for Mixed Fibrolamellar Hepatocellular Carcinoma

GenomeRNAi Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-135	9.1	ARG1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-140	9.1	ARG1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-148	9.1	ERBB2
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-163	9.1	ERBB2
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-60	9.1	ARG1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-99	9.1	ARG1

MGI Mouse Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.43	ERBB2 KRT19 PRKACA RASSF1 TACC2 TERT
2	normal	MP:0002873	9.17	ARG1 DNAJB1 ERBB2 KRT19 RASSF1 TACC2

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Drugs & Therapeutics for Mixed Fibrolamellar Hepatocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Mixed Fibrolamellar Hepatocellular Carcinoma

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Genetic Tests for Mixed Fibrolamellar Hepatocellular Carcinoma

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Anatomical Context for Mixed Fibrolamellar Hepatocellular Carcinoma

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Publications for Mixed Fibrolamellar Hepatocellular Carcinoma

Articles related to Mixed Fibrolamellar Hepatocellular Carcinoma:

#	Title	Authors	PMID	Year
1	A genomic case study of mixed fibrolamellar hepatocellular carcinoma. ⁶¹	Griffith OL...Mardis ER	27029710	2016
2	Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases. ⁶¹	Chagas AL...Alves VA	26017653	2015
3	Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection. ⁶¹	Malouf GG...Raymond E	22415897	2012

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Genes for Mixed Fibrolamellar Hepatocellular Carcinoma

Genes related to Mixed Fibrolamellar Hepatocellular Carcinoma (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DNAJB1	DnaJ Heat Shock Protein Family (Hsp40) Member B1	Protein Coding	12.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	7.16	GeneCards inferred via : Publications (show sections)
3	TTC33	Tetratricopeptide Repeat Domain 33	Protein Coding	6.88	DISEASES inferred ¹⁵
4	TACC2	Transforming Acidic Coiled-Coil Containing Protein 2	Protein Coding	5.64	DISEASES inferred ¹⁵
5	BCAS3	BCAS3 Microtubule Associated Cell Migration Factor	Protein Coding	5.49	DISEASES inferred ¹⁵
6	RASSF1	Ras Association Domain Family Member 1	Protein Coding	5.21	DISEASES inferred ¹⁵
7	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	4.91	DISEASES inferred ¹⁵
8	CLTC	Clathrin Heavy Chain	Protein Coding	4.63	DISEASES inferred ¹⁵
9	KRT7	Keratin 7	Protein Coding	4.3	DISEASES inferred ¹⁵
10	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	3.8	DISEASES inferred ¹⁵
11	ARG1	Arginase 1	Protein Coding	3.64	DISEASES inferred ¹⁵
12	KRT19	Keratin 19	Protein Coding	3.59	DISEASES inferred ¹⁵
13	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.4	DISEASES inferred ¹⁵
14	TERT	Telomerase Reverse Transcriptase	Protein Coding	3.38	DISEASES inferred ¹⁵

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Variations for Mixed Fibrolamellar Hepatocellular Carcinoma

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Expression for Mixed Fibrolamellar Hepatocellular Carcinoma

Search GEO for disease gene expression data for Mixed Fibrolamellar Hepatocellular Carcinoma.

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Pathways for Mixed Fibrolamellar Hepatocellular Carcinoma

Pathways related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.41	MUC1 KRT7 KRT19 CLTC
2	Tight junction ³⁶	11.36	PRKACA PRKAA1 ERBB2

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GO Terms for Mixed Fibrolamellar Hepatocellular Carcinoma

Cellular components related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	10	TERT TACC2 RASSF1 PRKACA PRKAA1 MUC1
2	cytosol	GO:0005829	9.85	TERT TACC2 PRKACA PRKAA1 KRT7 KRT19
3	cytoplasm	GO:0005737	9.4	TERT TACC2 RASSF1 PRKACA PRKAA1 MUC1
4	nucleotide-activated protein kinase complex	GO:0031588	8.96	PRKACA PRKAA1

Biological processes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to cadmium ion	GO:0046686	8.96	TERT ARG1
2	cellular response to glucagon stimulus	GO:0071377	8.62	PRKACA ARG1

Molecular functions related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear hormone receptor binding	GO:0035257	9.16	TACC2 BCAS3
2	AMP-activated protein kinase activity	GO:0004679	8.96	PRKACA PRKAA1
3	cAMP-dependent protein kinase activity	GO:0004691	8.62	PRKACA PRKAA1

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Sources for Mixed Fibrolamellar Hepatocellular Carcinoma

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