MCID: MXD042
MIFTS: 21

Mixed Fibrolamellar Hepatocellular Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Mixed Fibrolamellar Hepatocellular Carcinoma

MalaCards integrated aliases for Mixed Fibrolamellar Hepatocellular Carcinoma:

Name: Mixed Fibrolamellar Hepatocellular Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080182

Summaries for Mixed Fibrolamellar Hepatocellular Carcinoma

Disease Ontology : 12 A fibrolamellar carcinoma that is characteirzed by the presence of both pure fibrolamellar hepatocellular carcinoma and and conventional hepatocellular carcinoma components.

MalaCards based summary : Mixed Fibrolamellar Hepatocellular Carcinoma is related to fibrolamellar carcinoma and hepatocellular carcinoma. An important gene associated with Mixed Fibrolamellar Hepatocellular Carcinoma is PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha), and among its related pathways/superpathways are Pathways in cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include liver and bone, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection and Increased cell viability after pRB stimulation

Related Diseases for Mixed Fibrolamellar Hepatocellular Carcinoma

Diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fibrolamellar carcinoma 30.1 DNAJB1 PRKACA
2 hepatocellular carcinoma 10.1
3 breast fibroadenoma 9.8 ERBB2 RASSF1
4 cervical adenocarcinoma 9.8 ERBB2 RASSF1
5 respiratory system cancer 9.8 ERBB2 RASSF1
6 adamantinoma of long bones 9.8 ERBB2 RASSF1
7 cholangiocarcinoma 9.8 ERBB2 RASSF1
8 adenoid cystic carcinoma 9.7 ERBB2 RASSF1

Graphical network of the top 20 diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma:



Diseases related to Mixed Fibrolamellar Hepatocellular Carcinoma

Symptoms & Phenotypes for Mixed Fibrolamellar Hepatocellular Carcinoma

GenomeRNAi Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection GR00233-A-1 9.13 DNAJB1 ERBB2 RASSF1
2 Increased cell viability after pRB stimulation GR00230-A-1 8.62 ERBB2 PRKACA

MGI Mouse Phenotypes related to Mixed Fibrolamellar Hepatocellular Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 ERBB2 PRKACA RASSF1

Drugs & Therapeutics for Mixed Fibrolamellar Hepatocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Mixed Fibrolamellar Hepatocellular Carcinoma

Genetic Tests for Mixed Fibrolamellar Hepatocellular Carcinoma

Anatomical Context for Mixed Fibrolamellar Hepatocellular Carcinoma

MalaCards organs/tissues related to Mixed Fibrolamellar Hepatocellular Carcinoma:

41
Liver, Bone

Publications for Mixed Fibrolamellar Hepatocellular Carcinoma

Articles related to Mixed Fibrolamellar Hepatocellular Carcinoma:

# Title Authors Year
1
A genomic case study of mixed fibrolamellar hepatocellular carcinoma. ( 27029710 )
2016

Variations for Mixed Fibrolamellar Hepatocellular Carcinoma

Expression for Mixed Fibrolamellar Hepatocellular Carcinoma

Search GEO for disease gene expression data for Mixed Fibrolamellar Hepatocellular Carcinoma.

Pathways for Mixed Fibrolamellar Hepatocellular Carcinoma

GO Terms for Mixed Fibrolamellar Hepatocellular Carcinoma

Cellular components related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendritic spine GO:0043197 8.62 DNAJB1 PRKACA

Biological processes related to Mixed Fibrolamellar Hepatocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 8.62 ERBB2 PRKACA

Sources for Mixed Fibrolamellar Hepatocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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