MCID: MXD025
MIFTS: 20

Mixed Germ Cell Cancer

Categories: Cancer diseases

Aliases & Classifications for Mixed Germ Cell Cancer

MalaCards integrated aliases for Mixed Germ Cell Cancer:

Name: Mixed Germ Cell Cancer 12 15
Mixed Teratoma and Seminoma 12
Mixed Germ Cell Neoplasm 12
Mixed Germ Cell Tumour 12
Mixed Germ Cell Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3306
NCIt 50 C4290
SNOMED-CT 67 189853002
UMLS 70 C0334524

Summaries for Mixed Germ Cell Cancer

Disease Ontology : 12 A germ cell cancer that occurs in many forms.

MalaCards based summary : Mixed Germ Cell Cancer, also known as mixed teratoma and seminoma, is related to ovarian mixed germ cell neoplasm and seminoma. An important gene associated with Mixed Germ Cell Cancer is AFP (Alpha Fetoprotein). Related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Mixed Germ Cell Cancer

Diseases related to Mixed Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 ovarian mixed germ cell neoplasm 32.4 KIT AFP
2 seminoma 30.6 TNFRSF8 KIT AFP
3 mediastinum seminoma 30.3 KIT AFP
4 mixed germ cell tumor 30.3 KIT AFP
5 embryonal carcinoma 30.2 TNFRSF8 MIR302A KIT AFP
6 trophoblastic neoplasm 29.9 MIR371A AFP
7 testicular germ cell cancer 29.8 MIR371A KIT AFP
8 cryptorchidism, unilateral or bilateral 29.5 SALL4 KIT AFP
9 dysgerminoma 29.2 SALL4 MIR371A KIT AFP
10 germ cell cancer 28.7 SALL4 MIR371A MIR302A KIT AFP
11 germinoma 28.7 SALL4 MIR371A MIR302A KIT AFP
12 mature teratoma 28.7 TNFRSF8 SALL4 MIR371A MIR302A KIT AFP
13 childhood testicular mixed germ cell tumor 11.3
14 mixed extragonadal germ cell cancer 11.2
15 teratoma 10.5
16 choriocarcinoma 10.4
17 ovarian solid teratoma 10.2 TNFRSF8 AFP
18 intermediate malignant teratoma 10.2 TNFRSF8 AFP
19 ovarian embryonal carcinoma 10.2 TNFRSF8 AFP
20 testicular infarct 10.2 TNFRSF8 AFP
21 infected hydrocele 10.2 TNFRSF8 AFP
22 pineal region teratoma 10.2 KIT AFP
23 gallbladder leiomyosarcoma 10.2 KIT AFP
24 46,xy sex reversal 1 10.2
25 gonadal dysgenesis 10.2
26 46,xy sex reversal 10.2
27 testicular cancer 10.2
28 hypopituitarism 10.2
29 precocious puberty 10.2
30 liver leiomyoma 10.2 KIT AFP
31 esophageal adenoid cystic carcinoma 10.2 KIT AFP
32 sarcomatous intrahepatic cholangiocarcinoma 10.1 KIT AFP
33 endometrial small cell carcinoma 10.1 KIT AFP
34 liver leiomyosarcoma 10.1 KIT AFP
35 testicular lymphoma 10.1 TNFRSF8 FXYD5
36 brain germinoma 10.1 KIT AFP
37 embryonal testis carcinoma 10.1 TNFRSF8 AFP
38 pleural lipoma 10.1 TNFRSF8 KIT
39 seminal vesicle adenocarcinoma 10.1 KIT AFP
40 uterus leiomyosarcoma 10.1 TNFRSF8 KIT
41 conventional fibrosarcoma 10.1 TNFRSF8 KIT
42 uterine corpus sarcoma 10.1 TNFRSF8 KIT
43 hydrocele 10.1 MIR371A AFP
44 retinal detachment 10.0
45 mixed cell type cancer 10.0 KIT AFP
46 indolent systemic mastocytosis 10.0 TNFRSF8 KIT
47 systemic mastocytosis 10.0 TNFRSF8 KIT
48 precocious puberty, male-limited 10.0
49 gonadoblastoma 10.0
50 sarcoma 10.0

Graphical network of the top 20 diseases related to Mixed Germ Cell Cancer:



Diseases related to Mixed Germ Cell Cancer

Symptoms & Phenotypes for Mixed Germ Cell Cancer

MGI Mouse Phenotypes related to Mixed Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 AFP KIT PATZ1 TNFRSF8 YBX2 YBX3
2 reproductive system MP:0005389 9.1 AFP KIT PATZ1 SALL4 YBX2 YBX3

Drugs & Therapeutics for Mixed Germ Cell Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell Cancer

Genetic Tests for Mixed Germ Cell Cancer

Anatomical Context for Mixed Germ Cell Cancer

Publications for Mixed Germ Cell Cancer

Articles related to Mixed Germ Cell Cancer:

# Title Authors PMID Year
1
Germ cell cancer presenting as gastrointestinal bleeding and developing brain metastases: case report and review of the literature. 61
23148621 2012
2
Retroperitoneal mature teratoma 15 years after initial treatment of testicular mixed germ cell tumor. 61
11096252 2000

Variations for Mixed Germ Cell Cancer

Expression for Mixed Germ Cell Cancer

Search GEO for disease gene expression data for Mixed Germ Cell Cancer.

Pathways for Mixed Germ Cell Cancer

GO Terms for Mixed Germ Cell Cancer

Biological processes related to Mixed Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.54 YBX3 YBX2 PATZ1
2 somatic stem cell population maintenance GO:0035019 9.32 SALL4 KIT
3 stem cell population maintenance GO:0019827 9.26 SALL4 KIT
4 spermatogenesis GO:0007283 9.26 YBX3 YBX2 PATZ1 KIT
5 T cell differentiation GO:0030217 9.16 PATZ1 KIT
6 male gonad development GO:0008584 8.8 YBX3 PATZ1 KIT

Sources for Mixed Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....