MCID: MXD008
MIFTS: 29

Mixed Germ Cell-Sex Cord Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards integrated aliases for Mixed Germ Cell-Sex Cord Neoplasm:

Name: Mixed Germ Cell-Sex Cord Neoplasm 12 15
Mixed Germ Cell-Sex Cord-Stromal Tumor 12 74
Mixed Germ Cell-Sex Cord Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2996
NCIt 51 C5241
UMLS 74 C1321220

Summaries for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards based summary : Mixed Germ Cell-Sex Cord Neoplasm, also known as mixed germ cell-sex cord-stromal tumor, is related to sex cord-gonadal stromal tumor and gonadoblastoma. An important gene associated with Mixed Germ Cell-Sex Cord Neoplasm is TSPYL1 (TSPY Like 1), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary and testis, and related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Mixed Germ Cell-Sex Cord Neoplasm

Diseases related to Mixed Germ Cell-Sex Cord Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 31.0 CALB2 WT1
2 gonadoblastoma 30.6 KIT WT1
3 precocious puberty 10.4
4 leydig cell tumor 10.3
5 monosomy 22 10.3
6 malignant teratoma 10.2 POU5F1 SALL4
7 testicular infarct 10.2 KIT POU5F1
8 testicular leukemia 10.2 POU5F1 WT1
9 helsmoortel-van der aa syndrome 10.1 KIT SALL4
10 dysgerminoma 10.1 KIT WT1
11 testicular gonadoblastoma 10.1 KIT WT1
12 ovarian fibrothecoma 10.1 CALB2 KIT
13 ovarian melanoma 10.1 CALB2 KIT
14 mixed cell type cancer 10.1 KIT POU5F1
15 hypereosinophilic syndrome, idiopathic 10.1 KIT WT1
16 rete testis adenocarcinoma 10.1 CALB2 KIT
17 cystic nephroma 10.1 KIT WT1
18 fallopian tube carcinosarcoma 10.1 CALB2 WT1
19 neurogenic bowel 10.1 CALB2 KIT
20 heart sarcoma 10.1 KIT WT1
21 chronic eosinophilic leukemia 10.1 KIT WT1
22 rete testis neoplasm 10.1 CALB2 KIT
23 functional colonic disease 10.1 CALB2 KIT
24 malignant biphasic mesothelioma 10.1 CALB2 WT1
25 teratoma 10.1 DMRT1 KIT POU5F1
26 adenomatoid tumor 10.1 CALB2 WT1
27 congenital mesoblastic nephroma 10.1 KIT WT1
28 germ cell cancer 10.0 DMRT1 KIT POU5F1
29 sertoli cell tumor 10.0 CALB2 WT1
30 prostatic acinar adenocarcinoma 10.0 KIT WT1
31 46 xy gonadal dysgenesis 10.0 DMRT1 STAR WT1
32 intratubular embryonal carcinoma 10.0 KIT POU5F1 TCF4
33 sertoli-leydig cell tumor 10.0 CALB2 WT1
34 core binding factor acute myeloid leukemia 10.0 KIT WT1
35 46,xy partial gonadal dysgenesis 10.0 GATA4 WT1
36 pneumatosis cystoides intestinalis 10.0 CALB2 WT1
37 embryoma 10.0 KIT POU5F1 SALL4
38 extragonadal seminoma 10.0 KIT POU5F1 SALL4
39 colonic pseudo-obstruction 10.0 CALB2 KIT
40 pleural cancer 10.0 CALB2 WT1
41 malignant mesenchymoma 10.0 KIT WT1
42 uterine sarcoma 10.0 KIT WT1
43 testicular yolk sac tumor 10.0 POU5F1 SALL4
44 persistent mullerian duct syndrome 9.9 KIT WT1
45 malignant leydig cell tumor 9.9 CALB2 KIT POU5F1
46 venous hemangioma 9.9 CALB2 POU5F1 WT1
47 embryonal carcinoma 9.9 GATA4 KIT POU5F1
48 muscle cancer 9.9 KIT WT1
49 spermatocytoma 9.9 DMRT1 KIT SALL4 TSPYL1
50 peritoneal benign neoplasm 9.8 CALB2 KIT WT1

Graphical network of the top 20 diseases related to Mixed Germ Cell-Sex Cord Neoplasm:



Diseases related to Mixed Germ Cell-Sex Cord Neoplasm

Symptoms & Phenotypes for Mixed Germ Cell-Sex Cord Neoplasm

MGI Mouse Phenotypes related to Mixed Germ Cell-Sex Cord Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 DMRT1 GATA4 KIT POU5F1 STAR TCF4
2 reproductive system MP:0005389 9.17 DMRT1 GATA4 KIT POU5F1 SALL4 STAR

Drugs & Therapeutics for Mixed Germ Cell-Sex Cord Neoplasm

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell-Sex Cord Neoplasm

Genetic Tests for Mixed Germ Cell-Sex Cord Neoplasm

Anatomical Context for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards organs/tissues related to Mixed Germ Cell-Sex Cord Neoplasm:

42
Ovary, Testis

Publications for Mixed Germ Cell-Sex Cord Neoplasm

Articles related to Mixed Germ Cell-Sex Cord Neoplasm:

(show all 12)
# Title Authors Year
1
Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis. ( 27067782 )
2016
2
Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret. ( 25311985 )
2015
3
Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads. ( 26107563 )
2015
4
Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature. ( 25197407 )
2014
5
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. ( 22734844 )
2012
6
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. ( 18039910 )
2007
7
Recurrent mixed germ cell-sex cord-stromal tumor of the ovary in an adult. ( 9656127 )
1998
8
Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. ( 9219001 )
1997
9
Mixed germ cell-sex cord stromal tumor of the testis: the incidental finding of a rare testicular neoplasm. ( 7658567 )
1995
10
Mixed germ cell-sex cord stromal tumor with heterologous structures. ( 1328081 )
1992
11
A mixed germ cell-sex cord-stromal tumor of the ovary with retiform tubular structure: a case report. ( 2991152 )
1985
12
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. ( 7223719 )
1981

Variations for Mixed Germ Cell-Sex Cord Neoplasm

Expression for Mixed Germ Cell-Sex Cord Neoplasm

Search GEO for disease gene expression data for Mixed Germ Cell-Sex Cord Neoplasm.

Pathways for Mixed Germ Cell-Sex Cord Neoplasm

GO Terms for Mixed Germ Cell-Sex Cord Neoplasm

Cellular components related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.28 CALB2 DMRT1 GATA4 POU5F1 SALL4 TCF4

Biological processes related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.88 DMRT1 POU5F1 SALL4 TCFL5 WT1
2 positive regulation of gene expression GO:0010628 9.8 KIT POU5F1 STAR WT1
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 DMRT1 GATA4 POU5F1 SALL4 TCF4 WT1
4 regulation of transcription, DNA-templated GO:0006355 9.7 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5
5 transcription by RNA polymerase II GO:0006366 9.54 GATA4 POU5F1 TCFL5
6 heart development GO:0007507 9.52 SALL4 WT1
7 ventricular septum development GO:0003281 9.51 GATA4 SALL4
8 germ cell migration GO:0008354 9.46 DMRT1 KIT
9 cellular response to gonadotropin stimulus GO:0071371 9.43 STAR WT1
10 somatic stem cell population maintenance GO:0035019 9.43 KIT POU5F1 SALL4
11 positive regulation of male gonad development GO:2000020 9.4 DMRT1 WT1
12 male gonad development GO:0008584 9.02 DMRT1 GATA4 KIT STAR WT1
13 tissue development GO:0009888 8.96 SALL4 WT1

Molecular functions related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.7 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5
2 sequence-specific DNA binding GO:0043565 9.67 DMRT1 GATA4 POU5F1 WT1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.5 DMRT1 GATA4 WT1
4 DNA-binding transcription factor activity GO:0003700 9.43 DMRT1 GATA4 POU5F1 TCF4 TCFL5 WT1
5 cytokine binding GO:0019955 9.4 KIT POU5F1
6 enhancer sequence-specific DNA binding GO:0001158 9.26 GATA4 POU5F1
7 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5

Sources for Mixed Germ Cell-Sex Cord Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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