MCID: MXD008
MIFTS: 24

Mixed Germ Cell-Sex Cord Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards integrated aliases for Mixed Germ Cell-Sex Cord Neoplasm:

Name: Mixed Germ Cell-Sex Cord Neoplasm 12 15
Mixed Germ Cell-Sex Cord-Stromal Tumor 12 71
Mixed Germ Cell-Sex Cord Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2996
NCIt 49 C5241
UMLS 71 C1321220

Summaries for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards based summary : Mixed Germ Cell-Sex Cord Neoplasm, also known as mixed germ cell-sex cord-stromal tumor, is related to sex cord-gonadal stromal tumor and dysgerminoma. An important gene associated with Mixed Germ Cell-Sex Cord Neoplasm is TSPYL1 (TSPY Like 1), and among its related pathways/superpathways is Cardiac Progenitor Differentiation. Affiliated tissues include testis, liver and ovary, and related phenotype is normal.

Related Diseases for Mixed Germ Cell-Sex Cord Neoplasm

Diseases related to Mixed Germ Cell-Sex Cord Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 30.8 FOXL2 CALB2
2 dysgerminoma 30.6 KIT DMRT1
3 spermatocytoma 30.6 KIT DMRT1
4 endodermal sinus tumor 30.5 POU5F1 KIT
5 germinoma 30.3 POU5F1 KIT
6 testicular germ cell tumor 30.2 KIT DMRT1
7 seminoma 30.1 POU5F1 KIT DMRT1
8 embryonal carcinoma 30.1 POU5F1 KIT GATA4
9 wilms tumor 1 29.8 KIT GATA4 CALB2
10 gonadoblastoma 29.2 POU5F1 KIT FOXL2 DMRT1
11 testicular yolk sac tumor 10.5
12 precocious puberty 10.4
13 wilms tumor 5 10.3
14 leydig cell tumor 10.3
15 sertoli cell tumor 10.3
16 choriocarcinoma 10.3
17 ovarian endodermal sinus tumor 10.3
18 testicular spermatocytic seminoma 10.3
19 rare tumor 10.3
20 monosomy 22 10.3
21 ovarian fibrothecoma 10.0 KIT CALB2
22 liver fibroma 10.0 KIT CALB2
23 liver leiomyoma 10.0 KIT CALB2
24 mucinous stomach adenocarcinoma 10.0 KIT CALB2
25 retroperitoneal sarcoma 10.0 KIT CALB2
26 thymus clear cell carcinoma 10.0 KIT CALB2
27 adult mesoblastic nephroma 10.0 KIT CALB2
28 heart cancer 10.0 KIT CALB2
29 intratubular embryonal carcinoma 9.9 POU5F1 KIT
30 pleomorphic carcinoma 9.9 KIT CALB2
31 central nervous system germ cell tumor 9.9 POU5F1 KIT
32 connective tissue benign neoplasm 9.9 KIT CALB2
33 brain germinoma 9.9 POU5F1 KIT
34 cardiovascular cancer 9.9 KIT CALB2
35 cystic teratoma 9.9 KIT CALB2
36 malignant teratoma 9.9 POU5F1 KIT
37 intestinal obstruction 9.9 KIT GATA4
38 synovium cancer 9.9 KIT CALB2
39 benign teratoma 9.9 POU5F1 CALB2
40 mature teratoma 9.9 POU5F1 KIT
41 thymic carcinoma 9.9 KIT CALB2
42 leiomyomatosis 9.9 KIT CALB2
43 hermaphroditism 9.8 FOXL2 DMRT1
44 cystadenoma 9.8 KIT CALB2
45 cryptorchidism, unilateral or bilateral 9.8 KIT GATA4 DMRT1
46 gynandroblastoma 9.8 FOXL2 CALB2
47 adult type testicular granulosa cell tumor 9.8 FOXL2 CALB2
48 testicular granulosa cell tumor 9.8 FOXL2 CALB2
49 ovarian wilms' cancer 9.8 FOXL2 CALB2
50 megacolon 9.8 KIT CALB2

Graphical network of the top 20 diseases related to Mixed Germ Cell-Sex Cord Neoplasm:



Diseases related to Mixed Germ Cell-Sex Cord Neoplasm

Symptoms & Phenotypes for Mixed Germ Cell-Sex Cord Neoplasm

MGI Mouse Phenotypes related to Mixed Germ Cell-Sex Cord Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.02 CALB2 FOXL2 GATA4 KIT POU5F1

Drugs & Therapeutics for Mixed Germ Cell-Sex Cord Neoplasm

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell-Sex Cord Neoplasm

Genetic Tests for Mixed Germ Cell-Sex Cord Neoplasm

Anatomical Context for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards organs/tissues related to Mixed Germ Cell-Sex Cord Neoplasm:

40
Testis, Liver, Ovary, Thymus, Brain, Heart

Publications for Mixed Germ Cell-Sex Cord Neoplasm

Articles related to Mixed Germ Cell-Sex Cord Neoplasm:

(show all 23)
# Title Authors PMID Year
1
Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis. 61
30067948 2018
2
Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms. 61
28445692 2017
3
[Mixed germ cell sex cord stromal tumor of ovary: report of a case]. 61
27142920 2016
4
Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis. 61
27067782 2016
5
Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads. 61
26107563 2015
6
Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret. 61
25311985 2015
7
Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature. 61
25197407 2014
8
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 61
22734844 2012
9
Precocious puberty in a 7-year-old boy: a novel case. 61
19525149 2009
10
Bilateral testicular germ cell-sex cord-stromal tumor in a pekin duck (Anas platyrhynchos domesticus). 61
19216259 2008
11
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. 61
18039910 2007
12
Recent advances in the pathology and classification of gonadal neoplasms composed of germ cells and sex cord derivatives. 61
17581418 2007
13
[Mixed germ cell-sex cord-stromal tumor: report of a case]. 61
17374265 2006
14
Distribution of Y-chromosome-bearing cells in gonadoblastoma and dysgenetic testis in 45,X/46,XY infants. 61
15475933 2005
15
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. 61
15502809 2005
16
Neoplastic potential of germ cells in relation to disturbances of gonadal organogenesis and changes in karyotype. 61
12634315 2003
17
Sex cord-stromal tumors of the testis with entrapped germ cells: a lesion mimicking unclassified mixed germ cell sex cord-stromal tumors. 61
10757400 2000
18
Recurrent mixed germ cell-sex cord-stromal tumor of the ovary in an adult. 61
9656127 1998
19
Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. 61
9219001 1997
20
Mixed germ cell-sex cord stromal tumor of the testis: the incidental finding of a rare testicular neoplasm. 61
7658567 1995
21
Mixed germ cell-sex cord stromal tumor with heterologous structures. 61
1328081 1992
22
A mixed germ cell-sex cord-stromal tumor of the ovary with retiform tubular structure: a case report. 61
2991152 1985
23
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. 61
7223719 1981

Variations for Mixed Germ Cell-Sex Cord Neoplasm

Expression for Mixed Germ Cell-Sex Cord Neoplasm

Search GEO for disease gene expression data for Mixed Germ Cell-Sex Cord Neoplasm.

Pathways for Mixed Germ Cell-Sex Cord Neoplasm

Pathways related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 POU5F1 KIT GATA4

GO Terms for Mixed Germ Cell-Sex Cord Neoplasm

Cellular components related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 TCFL5 POU5F1 GATA4 FOXL2 DMRT1

Biological processes related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.71 POU5F1 GATA4 FOXL2 DMRT1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.62 TCFL5 POU5F1 FOXL2 DMRT1
3 regulation of transcription, DNA-templated GO:0006355 9.55 TCFL5 POU5F1 GATA4 FOXL2 DMRT1
4 somatic stem cell population maintenance GO:0035019 9.37 POU5F1 KIT
5 ovarian follicle development GO:0001541 9.26 KIT FOXL2
6 male gonad development GO:0008584 9.13 KIT GATA4 DMRT1
7 germ cell migration GO:0008354 8.62 KIT DMRT1

Molecular functions related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.8 TCFL5 POU5F1 GATA4 FOXL2 DMRT1
2 sequence-specific DNA binding GO:0043565 9.56 POU5F1 GATA4 FOXL2 DMRT1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.54 GATA4 FOXL2 DMRT1
4 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.35 TCFL5 POU5F1 GATA4 FOXL2 DMRT1
5 cytokine binding GO:0019955 9.32 POU5F1 KIT
6 enhancer sequence-specific DNA binding GO:0001158 9.16 POU5F1 GATA4
7 DNA-binding transcription factor activity GO:0003700 9.02 TCFL5 POU5F1 GATA4 FOXL2 DMRT1

Sources for Mixed Germ Cell-Sex Cord Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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