MCID: MXD008
MIFTS: 29

Mixed Germ Cell-Sex Cord Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards integrated aliases for Mixed Germ Cell-Sex Cord Neoplasm:

Name: Mixed Germ Cell-Sex Cord Neoplasm 12 15
Mixed Germ Cell-Sex Cord-Stromal Tumor 12 72
Mixed Germ Cell-Sex Cord Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2996
NCIt 50 C5241
UMLS 72 C1321220

Summaries for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards based summary : Mixed Germ Cell-Sex Cord Neoplasm, also known as mixed germ cell-sex cord-stromal tumor, is related to embryonal carcinoma and seminoma. An important gene associated with Mixed Germ Cell-Sex Cord Neoplasm is TSPYL1 (TSPY Like 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Cardiac Progenitor Differentiation. Affiliated tissues include testis and ovary, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Related Diseases for Mixed Germ Cell-Sex Cord Neoplasm

Diseases related to Mixed Germ Cell-Sex Cord Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 embryonal carcinoma 31.3 POU5F1 KIT GATA4
2 seminoma 31.1 POU5F1 KIT ENO2
3 dysgerminoma 30.8 WT1 KIT ENO2
4 spermatocytoma 30.7 TSPYL1 SALL4 KIT DMRT1
5 sex cord-gonadal stromal tumor 30.6 WT1 FOXL2 CALB2
6 gonadoblastoma 30.3 WT1 SOX9 KIT FOXL2
7 sertoli cell tumor 30.0 WT1 CALB2
8 cutaneous ganglioneuroma 10.5 KIT ENO2
9 gastric leiomyosarcoma 10.5 KIT ENO2
10 endometrial small cell carcinoma 10.5 KIT ENO2
11 conventional fibrosarcoma 10.5 KIT ENO2
12 endodermal sinus tumor 10.5
13 testicular yolk sac tumor 10.5
14 plexiform schwannoma 10.5 KIT ENO2
15 prostate small cell carcinoma 10.5 KIT ENO2
16 angiomyoma 10.4 KIT ENO2
17 germ cell cancer 10.4 POU5F1 KIT DMRT1
18 intratubular embryonal carcinoma 10.4 TCF4 POU5F1 KIT
19 precocious puberty 10.4
20 helsmoortel-van der aa syndrome 10.4 SALL4 KIT
21 testicular gonadoblastoma 10.4 WT1 KIT
22 mixed gonadal dysgenesis 10.4 SOX9 FOXL2
23 malignant anus melanoma 10.4 MLANA KIT
24 embryoma 10.4 SALL4 POU5F1 KIT
25 extragonadal seminoma 10.4 SALL4 POU5F1 KIT
26 hypereosinophilic syndrome, idiopathic 10.4 WT1 KIT
27 breast angiosarcoma 10.4 MLANA KIT
28 diverticulitis of colon 10.4 UCHL1 KIT
29 cystic nephroma 10.3 WT1 KIT
30 testicular leukemia 10.3 WT1 POU5F1
31 mixed cell type cancer 10.3 POU5F1 KIT ENO2
32 juvenile type testicular granulosa cell tumor 10.3 WT1 FOXL2
33 testicular granulosa cell tumor 10.3 WT1 FOXL2
34 malignant teratoma 10.3 SALL4 POU5F1 ENO2
35 epicanthus 10.3 TCF4 FOXL2
36 kidney rhabdoid cancer 10.3 WT1 ENO2
37 rhabdoid cancer 10.3 WT1 ENO2
38 male reproductive organ benign neoplasm 10.3 WT1 FOXL2
39 wilms tumor 1 10.3
40 testicular germ cell tumor 10.3
41 wilms tumor 5 10.3
42 leydig cell tumor 10.3
43 germinoma 10.3
44 choriocarcinoma 10.3
45 ovarian endodermal sinus tumor 10.3
46 testicular spermatocytic seminoma 10.3
47 ovarian sex cord tumor with annular tubules 10.3
48 rare tumor 10.3
49 monosomy 22 10.3
50 gastric small cell carcinoma 10.3 UCHL1 ENO2

Graphical network of the top 20 diseases related to Mixed Germ Cell-Sex Cord Neoplasm:



Diseases related to Mixed Germ Cell-Sex Cord Neoplasm

Symptoms & Phenotypes for Mixed Germ Cell-Sex Cord Neoplasm

MGI Mouse Phenotypes related to Mixed Germ Cell-Sex Cord Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ENO2 FOXL2 GATA4 KIT SALL4 SOX9
2 endocrine/exocrine gland MP:0005379 10.09 DMRT1 FOXL2 GATA4 KIT POU5F1 SOX9
3 nervous system MP:0003631 9.97 CALB2 ENO2 GATA4 KIT POU5F1 SALL4
4 digestive/alimentary MP:0005381 9.93 GATA4 KIT POU5F1 SALL4 SOX9 UCHL1
5 limbs/digits/tail MP:0005371 9.85 GATA4 KIT SALL4 SOX9 TCF4 UCHL1
6 no phenotypic analysis MP:0003012 9.73 FOXL2 GATA4 KIT MLANA SOX9 WT1
7 normal MP:0002873 9.7 CALB2 FOXL2 GATA4 KIT POU5F1 SOX9
8 reproductive system MP:0005389 9.61 DMRT1 FOXL2 GATA4 KIT POU5F1 SALL4
9 respiratory system MP:0005388 9.1 ENO2 GATA4 KIT SOX9 UCHL1 WT1

Drugs & Therapeutics for Mixed Germ Cell-Sex Cord Neoplasm

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell-Sex Cord Neoplasm

Genetic Tests for Mixed Germ Cell-Sex Cord Neoplasm

Anatomical Context for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards organs/tissues related to Mixed Germ Cell-Sex Cord Neoplasm:

41
Testis, Ovary

Publications for Mixed Germ Cell-Sex Cord Neoplasm

Articles related to Mixed Germ Cell-Sex Cord Neoplasm:

(show all 23)
# Title Authors PMID Year
1
Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis. 38
30067948 2018
2
Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms. 38
28445692 2017
3
[Mixed germ cell sex cord stromal tumor of ovary: report of a case]. 38
27142920 2016
4
Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis. 38
27067782 2016
5
Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads. 38
26107563 2015
6
Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret. 38
25311985 2015
7
Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature. 38
25197407 2014
8
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 38
22734844 2012
9
Precocious puberty in a 7-year-old boy: a novel case. 38
19525149 2009
10
Bilateral testicular germ cell-sex cord-stromal tumor in a pekin duck (Anas platyrhynchos domesticus). 38
19216259 2008
11
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. 38
18039910 2007
12
Recent advances in the pathology and classification of gonadal neoplasms composed of germ cells and sex cord derivatives. 38
17581418 2007
13
[Mixed germ cell-sex cord-stromal tumor: report of a case]. 38
17374265 2006
14
Distribution of Y-chromosome-bearing cells in gonadoblastoma and dysgenetic testis in 45,X/46,XY infants. 38
15475933 2005
15
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. 38
15502809 2005
16
Neoplastic potential of germ cells in relation to disturbances of gonadal organogenesis and changes in karyotype. 38
12634315 2003
17
Sex cord-stromal tumors of the testis with entrapped germ cells: a lesion mimicking unclassified mixed germ cell sex cord-stromal tumors. 38
10757400 2000
18
Recurrent mixed germ cell-sex cord-stromal tumor of the ovary in an adult. 38
9656127 1998
19
Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. 38
9219001 1997
20
Mixed germ cell-sex cord stromal tumor of the testis: the incidental finding of a rare testicular neoplasm. 38
7658567 1995
21
Mixed germ cell-sex cord stromal tumor with heterologous structures. 38
1328081 1992
22
A mixed germ cell-sex cord-stromal tumor of the ovary with retiform tubular structure: a case report. 38
2991152 1985
23
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. 38
7223719 1981

Variations for Mixed Germ Cell-Sex Cord Neoplasm

Expression for Mixed Germ Cell-Sex Cord Neoplasm

Search GEO for disease gene expression data for Mixed Germ Cell-Sex Cord Neoplasm.

Pathways for Mixed Germ Cell-Sex Cord Neoplasm

Pathways related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 WT1 SOX9 POU5F1 GATA4
2 10.86 POU5F1 KIT GATA4

GO Terms for Mixed Germ Cell-Sex Cord Neoplasm

Biological processes related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 WT1 TCF4 SOX9 GATA4 FOXL2
2 cell differentiation GO:0030154 9.93 TCFL5 TCF4 SOX9 FOXL2 DMRT1
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 WT1 TCFL5 SALL4 POU5F1 FOXL2 DMRT1
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 WT1 TCF4 SOX9 SALL4 POU5F1 GATA4
5 regulation of transcription, DNA-templated GO:0006355 9.91 WT1 TCFL5 TCF4 SOX9 SALL4 POU5F1
6 positive regulation of gene expression GO:0010628 9.83 WT1 STAR SOX9 POU5F1 KIT
7 heart development GO:0007507 9.69 WT1 SOX9 SALL4
8 male sex determination GO:0030238 9.57 SOX9 DMRT1
9 Sertoli cell development GO:0060009 9.55 SOX9 DMRT1
10 germ cell migration GO:0008354 9.52 KIT DMRT1
11 cellular response to gonadotropin stimulus GO:0071371 9.49 WT1 STAR
12 Sertoli cell differentiation GO:0060008 9.48 SOX9 DMRT1
13 somatic stem cell population maintenance GO:0035019 9.46 SOX9 SALL4 POU5F1 KIT
14 transcription by RNA polymerase II GO:0006366 9.4 TCFL5 POU5F1
15 tissue development GO:0009888 9.37 WT1 SALL4
16 positive regulation of male gonad development GO:2000020 9.13 WT1 SOX9 DMRT1
17 male gonad development GO:0008584 9.1 WT1 STAR SOX9 KIT GATA4 DMRT1

Molecular functions related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 WT1 TCFL5 TCF4 SOX9 SALL4 POU5F1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.8 TCFL5 TCF4 SOX9 GATA4 FOXL2
3 sequence-specific DNA binding GO:0043565 9.73 WT1 SOX9 POU5F1 GATA4 FOXL2 DMRT1
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.67 WT1 SOX9 GATA4 DMRT1
5 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.61 WT1 TCFL5 TCF4 SOX9 SALL4 POU5F1
6 bHLH transcription factor binding GO:0043425 9.43 TCF4 SOX9
7 enhancer sequence-specific DNA binding GO:0001158 9.33 SOX9 POU5F1 GATA4
8 DNA-binding transcription factor activity GO:0003700 9.23 WT1 TCFL5 TCF4 SOX9 POU5F1 GATA4

Sources for Mixed Germ Cell-Sex Cord Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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