MCID: MXD008
MIFTS: 31

Mixed Germ Cell-Sex Cord Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards integrated aliases for Mixed Germ Cell-Sex Cord Neoplasm:

Name: Mixed Germ Cell-Sex Cord Neoplasm 12 15
Mixed Germ Cell-Sex Cord-Stromal Tumor 12 73
Mixed Germ Cell-Sex Cord Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2996
NCIt 50 C5241
UMLS 73 C1321220

Summaries for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards based summary : Mixed Germ Cell-Sex Cord Neoplasm, also known as mixed germ cell-sex cord-stromal tumor, is related to sex cord-gonadal stromal tumor and gonadoblastoma. An important gene associated with Mixed Germ Cell-Sex Cord Neoplasm is TSPYL1 (TSPY Like 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Cardiac Progenitor Differentiation. Affiliated tissues include ovary, testis and colon, and related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Mixed Germ Cell-Sex Cord Neoplasm

Diseases related to Mixed Germ Cell-Sex Cord Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 31.1 CALB2 WT1
2 gonadoblastoma 30.4 KIT TSPY1 WT1
3 endodermal sinus tumor 10.2
4 leydig cell tumor 10.2
5 precocious puberty 10.2
6 monosomy 22 10.2
7 sudden infant death with dysgenesis of the testes syndrome 10.2 TSPY1 TSPYL1
8 malignant teratoma 10.2 POU5F1 SALL4
9 testicular infarct 10.2 KIT POU5F1
10 testicular leukemia 10.1 POU5F1 WT1
11 helsmoortel-van der aa syndrome 10.1 KIT SALL4
12 testicular gonadoblastoma 10.1 KIT WT1
13 hypereosinophilic syndrome, idiopathic 10.1 KIT WT1
14 cystic nephroma 10.1 KIT WT1
15 ovarian fibrothecoma 10.1 CALB2 KIT
16 ovarian melanoma 10.1 CALB2 KIT
17 heart sarcoma 10.1 KIT WT1
18 mixed cell type cancer 10.1 KIT POU5F1
19 chronic eosinophilic leukemia 10.1 KIT WT1
20 rete testis adenocarcinoma 10.1 CALB2 KIT
21 fallopian tube carcinosarcoma 10.1 CALB2 WT1
22 seminoma 10.1 KIT POU5F1 TSPY1
23 46,xy partial gonadal dysgenesis 10.1 GATA4 WT1
24 gonadal dysgenesis 10.1 DMRT1 TSPY1 WT1
25 teratoma 10.1 DMRT1 KIT POU5F1
26 neurogenic bowel 10.1 CALB2 KIT
27 germ cell cancer 10.1 DMRT1 KIT POU5F1
28 congenital mesoblastic nephroma 10.1 KIT WT1
29 46 xy gonadal dysgenesis 10.1 DMRT1 STAR WT1
30 intratubular embryonal carcinoma 10.1 KIT POU5F1 TCF4
31 malignant biphasic mesothelioma 10.1 CALB2 WT1
32 prostatic acinar adenocarcinoma 10.1 KIT WT1
33 adenomatoid tumor 10.1 CALB2 WT1
34 rete testis neoplasm 10.1 CALB2 KIT
35 sertoli cell tumor 10.0 CALB2 WT1
36 functional colonic disease 10.0 CALB2 KIT
37 embryoma 10.0 KIT POU5F1 SALL4
38 core binding factor acute myeloid leukemia 10.0 KIT WT1
39 extragonadal seminoma 10.0 KIT POU5F1 SALL4
40 sertoli-leydig cell tumor 10.0 CALB2 WT1
41 dysgerminoma 10.0 KIT TSPY1 WT1
42 pneumatosis cystoides intestinalis 10.0 CALB2 WT1
43 malignant mesenchymoma 10.0 KIT WT1
44 pleural cancer 10.0 CALB2 WT1
45 colonic pseudo-obstruction 10.0 CALB2 KIT
46 embryonal carcinoma 10.0 GATA4 KIT POU5F1
47 uterine sarcoma 10.0 KIT WT1
48 malignant leydig cell tumor 10.0 CALB2 KIT POU5F1
49 spermatocytoma 10.0 DMRT1 KIT SALL4 TSPYL1
50 venous hemangioma 10.0 CALB2 POU5F1 WT1

Graphical network of the top 20 diseases related to Mixed Germ Cell-Sex Cord Neoplasm:



Diseases related to Mixed Germ Cell-Sex Cord Neoplasm

Symptoms & Phenotypes for Mixed Germ Cell-Sex Cord Neoplasm

MGI Mouse Phenotypes related to Mixed Germ Cell-Sex Cord Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 DMRT1 GATA4 KIT POU5F1 STAR TCF4
2 reproductive system MP:0005389 9.17 DMRT1 GATA4 KIT POU5F1 SALL4 STAR

Drugs & Therapeutics for Mixed Germ Cell-Sex Cord Neoplasm

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell-Sex Cord Neoplasm

Genetic Tests for Mixed Germ Cell-Sex Cord Neoplasm

Anatomical Context for Mixed Germ Cell-Sex Cord Neoplasm

MalaCards organs/tissues related to Mixed Germ Cell-Sex Cord Neoplasm:

41
Ovary, Testis, Colon, Heart, Testes, Prostate, Myeloid

Publications for Mixed Germ Cell-Sex Cord Neoplasm

Articles related to Mixed Germ Cell-Sex Cord Neoplasm:

(show all 12)
# Title Authors Year
1
Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis. ( 27067782 )
2016
2
Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret. ( 25311985 )
2015
3
Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads. ( 26107563 )
2015
4
Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature. ( 25197407 )
2014
5
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. ( 22734844 )
2012
6
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. ( 18039910 )
2007
7
Recurrent mixed germ cell-sex cord-stromal tumor of the ovary in an adult. ( 9656127 )
1998
8
Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. ( 9219001 )
1997
9
Mixed germ cell-sex cord stromal tumor of the testis: the incidental finding of a rare testicular neoplasm. ( 7658567 )
1995
10
Mixed germ cell-sex cord stromal tumor with heterologous structures. ( 1328081 )
1992
11
A mixed germ cell-sex cord-stromal tumor of the ovary with retiform tubular structure: a case report. ( 2991152 )
1985
12
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. ( 7223719 )
1981

Variations for Mixed Germ Cell-Sex Cord Neoplasm

Expression for Mixed Germ Cell-Sex Cord Neoplasm

Search GEO for disease gene expression data for Mixed Germ Cell-Sex Cord Neoplasm.

Pathways for Mixed Germ Cell-Sex Cord Neoplasm

Pathways related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 GATA4 POU5F1 WT1
2 10.52 GATA4 KIT POU5F1

GO Terms for Mixed Germ Cell-Sex Cord Neoplasm

Cellular components related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 CALB2 DMRT1 GATA4 POU5F1 SALL4 TCF4

Biological processes related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 DMRT1 POU5F1 TCFL5 TSPY1 TSPY10
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 DMRT1 GATA4 POU5F1 SALL4 TCF4 WT1
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 DMRT1 POU5F1 SALL4 TCFL5 WT1
4 transcription by RNA polymerase II GO:0006366 9.88 DMRT1 GATA4 POU5F1 TCFL5 WT1
5 regulation of transcription, DNA-templated GO:0006355 9.87 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5
6 positive regulation of gene expression GO:0010628 9.85 KIT POU5F1 STAR WT1
7 cell differentiation GO:0030154 9.85 DMRT1 KIT TCF4 TCFL5 TSPY1 TSPY10
8 heart development GO:0007507 9.76 GATA4 SALL4 WT1
9 nucleosome assembly GO:0006334 9.7 TSPY1 TSPY10 TSPYL1
10 spermatogenesis GO:0007283 9.65 DMRT1 KIT TCFL5 TSPY1 TSPY10
11 ventricular septum development GO:0003281 9.57 GATA4 SALL4
12 sex differentiation GO:0007548 9.56 DMRT1 TSPY1
13 germ cell migration GO:0008354 9.51 DMRT1 KIT
14 cellular response to gonadotropin stimulus GO:0071371 9.46 STAR WT1
15 gonadal mesoderm development GO:0007506 9.43 TSPY1 TSPY10
16 positive regulation of male gonad development GO:2000020 9.4 DMRT1 WT1
17 somatic stem cell population maintenance GO:0035019 9.33 KIT POU5F1 SALL4
18 tissue development GO:0009888 9.13 GATA4 SALL4 WT1
19 male gonad development GO:0008584 9.02 DMRT1 GATA4 KIT STAR WT1

Molecular functions related to Mixed Germ Cell-Sex Cord Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.7 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.5 DMRT1 GATA4 WT1
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.5 DMRT1 GATA4 POU5F1 SALL4 TCF4 TCFL5
4 cytokine binding GO:0019955 9.37 KIT POU5F1
5 enhancer sequence-specific DNA binding GO:0001158 9.26 GATA4 POU5F1
6 DNA-binding transcription factor activity GO:0003700 9.1 DMRT1 GATA4 POU5F1 TCF4 TCFL5 WT1

Sources for Mixed Germ Cell-Sex Cord Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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