MCID: MXD032
MIFTS: 24

Mixed Germ Cell Tumor

Categories: Rare diseases

Aliases & Classifications for Mixed Germ Cell Tumor

MalaCards integrated aliases for Mixed Germ Cell Tumor:

Name: Mixed Germ Cell Tumor 58 70

Classifications:



External Ids:

UMLS via Orphanet 71 C0334524
Orphanet 58 ORPHA180234
UMLS 70 C0334524

Summaries for Mixed Germ Cell Tumor

MalaCards based summary : Mixed Germ Cell Tumor is related to mixed germ cell cancer and ovarian mixed germ cell neoplasm. An important gene associated with Mixed Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Peptide hormone metabolism and Glucocorticoid receptor regulatory network. Affiliated tissues include ovary, testis and pineal.

Related Diseases for Mixed Germ Cell Tumor

Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell cancer 32.0 KIT AFP
2 ovarian mixed germ cell neoplasm 31.8 KIT CGA AFP
3 mature teratoma 30.9 KIT AFP
4 endodermal sinus tumor 30.8 CGB3 AFP
5 dysgerminoma 30.8 KIT AFP
6 polyembryoma 30.6 CGA AFP
7 choriocarcinoma 30.5 CGB3 CGA
8 gonadoblastoma 30.4 KIT CGB3
9 embryonal carcinoma 30.3 KIT CGB3 AFP
10 testicular germ cell tumor 30.3 KIT AFP
11 teratoma 30.3 KIT CGB3 CGA AFP
12 testicular germ cell cancer 30.2 KIT AFP
13 germ cell cancer 30.1 KIT CGA AFP
14 ovarian gonadoblastoma 30.0 KIT AFP
15 ovarian germ cell cancer 30.0 KIT AFP
16 malignant teratoma 30.0 KIT AFP
17 spermatocytoma 29.9 KIT AFP
18 testicular cancer 29.9 CGB3 CGA AFP
19 hydrocele 29.9 CGA AFP
20 germinoma 29.8 KIT CGB3 CGA AFP
21 cryptorchidism, unilateral or bilateral 29.8 KIT CGA AFP
22 seminoma 29.7 KIT CGB3 CGA AFP
23 trophoblastic neoplasm 29.5 CGB3 CGA AFP
24 childhood central nervous system mixed germ cell tumor 11.6
25 childhood testicular mixed germ cell tumor 11.5
26 mixed germ cell tumor of central nervous system 11.5
27 adult central nervous system mixed germ cell tumor 11.3
28 teratocarcinoma 11.3
29 germ cells tumors 11.1
30 testicular yolk sac tumor 10.7
31 gonadal dysgenesis 10.4
32 persistent mullerian duct syndrome 10.3
33 hydrocephalus 10.3
34 rhabdomyosarcoma 10.3
35 inguinal hernia 10.2
36 obstructive hydrocephalus 10.2
37 pineoblastoma 10.2
38 pseudohermaphroditism 10.2
39 pineal gland cancer 10.2
40 diabetes insipidus 10.2
41 pineocytoma 10.2
42 growing teratoma syndrome 10.2
43 sarcoma, synovial 10.1
44 ataxia and polyneuropathy, adult-onset 10.1
45 meningioma, familial 10.1
46 testicular microlithiasis 10.1
47 intracranial meningioma 10.1
48 sarcoma 10.1
49 leiomyosarcoma 10.1
50 cystic teratoma 10.1

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to Mixed Germ Cell Tumor

Symptoms & Phenotypes for Mixed Germ Cell Tumor

Drugs & Therapeutics for Mixed Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

Anatomical Context for Mixed Germ Cell Tumor

MalaCards organs/tissues related to Mixed Germ Cell Tumor:

40
Ovary, Testis, Pineal, Lymph Node, Pituitary, Spinal Cord, Prostate

Publications for Mixed Germ Cell Tumor

Articles related to Mixed Germ Cell Tumor:

(show top 50) (show all 441)
# Title Authors PMID Year
1
177Lu-PSMA Therapy for Metastatic Testicular Mixed Germ Cell Tumor. 61
33630811 2021
2
The development of numerous radiation-induced cavernous malformations in a germ cell tumor patient: A case report. 61
32958338 2021
3
Surveillance Only for High-risk FIGO Stage IA/IB Malignant Ovarian Germ Cell Tumors: Results From a National Cancer Database. 61
33710136 2021
4
Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of a case of a huge abdominal mass. 61
33222481 2021
5
Ovarian mixed germ-cell tumor comprising mature teratoma and embryonal carcinoma in a four-toed hedgehog (Atelerix albiventris). 61
33536394 2021
6
[Pathological features of primary extragonadal germ cell tumor of the prostate with small round blue cell morphology]. 61
33535304 2021
7
Clinicopathological Features, Prognostic Factors, Survival Trends, and Treatment of Malignant Ovarian Germ Cell Tumors: A SEER Database Analysis. 61
33706324 2021
8
Testicular non-seminomatous mixed germ cell tumor with rhabdomyosarcoma and retroperitoneal metastatic mass: A case report. 61
33294376 2021
9
Growing Teratoma Syndrome: A Rare Outcome. 61
33489412 2021
10
Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling. 61
33796464 2021
11
Mediastinal Germ Cell Tumor with Testicular Microlithiasis. 61
33614354 2021
12
Therapy-related acute promyelocytic leukemia in a patient with testicular mixed germ cell tumor. 61
33402559 2021
13
Nivolumab for the salvage treatment of desperate germ cell tumor: A case report. 61
33283628 2020
14
Discrepancy in pathology reports upon second review of radical orchiectomy specimens for testicular germ cell tumors. 61
32574142 2020
15
Lack of genetic homozygosity in prepubertal teratomas: divergent pathogenesis distinct from that of teratomas in adolescents. 61
32694569 2020
16
[Primary mediastinal malignant mixed germ cell tumor: a case report]. 61
33256314 2020
17
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
18
Malignant melanoma arising in a primary mediastinal germ cell tumor. 61
32950894 2020
19
Rare Estradiol Secreting Testicular Mixed Germ Cell Tumor Presenting with Cutaneous Metastasis. 61
32856977 2020
20
Rare Case of Mixed Germ Cell Tumor With Leiomyosarcoma in Bilateral Undescended Testis. 61
32380156 2020
21
Microneurosurgical Removal of a Globus Pallidus Tumor With Cottonoid-Guided Intraoperative Ultrasonography: 2-Dimensional Operative Video. 61
31768549 2020
22
Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients. 61
32771066 2020
23
[Intracranial Growing Teratoma Syndrome:Case Reports and Literature Review]. 61
32694227 2020
24
Testicular Mixed Germ Cell Tumor Combined with Malignant Transformation to Chondrosarcoma: A Very Rare and Aggressive Disease. 61
32587232 2020
25
Osteopoikilosis With Germline LEMD3 Mutation Mimicking Bone Metastases in a Girl With a Concurrent Secreting Mixed Germ Cell Tumor. 61
30951020 2020
26
Be cautious of "complex hydrocele" on ultrasound in young men. 61
32255327 2020
27
Trends in the surgical management of malignant ovarian germcell tumors. 61
32008791 2020
28
A primary third ventricle mixed germ cell tumor with leptomeningeal dissemination of immature teratoma component. 61
31418081 2020
29
[Ultrasonographic and clinical features of common testicular germ cell tumors in children]. 61
33346418 2020
30
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report. 61
32974172 2020
31
Acute abdomen caused by rupture of a torted intra-abdominal testicular mass: Case report. 61
32193141 2020
32
A Clinical Analysis of the Diagnosis and Treatment of Fetal Sacrococcygeal Teratomas. 61
33380826 2020
33
Clinical stage I synchronous bilateral testicular germ cell tumor with different histopathology: a case report. 61
33680279 2020
34
A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male. 61
31984143 2020
35
Concurrent bilateral testicular tumors with different histopathology: A case report. 61
33680389 2020
36
Mixed Germ Cell Tumor of the Endometrium: A Case Report and Literature Review. 61
32064359 2020
37
Non seminomatous mixed germ cell tumor of the testis with predominant component of somatic type malignancy (Rhabdomyosarcoma) - A rare occurrence. 61
32031141 2020
38
Testicular Mixed Germ Cell Tumor in a Newborn Child: A Rare Case. 61
31896907 2020
39
Adult-Onset Mixed Germ Cell Tumor Composed Mainly of Yolk Sac Tumor Around the Pineal Gland: A Case Report and Review of the Literature. 61
31470154 2019
40
Classic and "Dissecting" Gonadoblastoma in a Phenotypic Girl With a 46, XX Peripheral Karyotype and No Evidence of a Disorder of Sex Development. 61
30252730 2019
41
Management of Stage II Germ Cell Tumors: Be Sure, Be Patient, Be Safe. 61
31180818 2019
42
Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia. 61
30907201 2019
43
Endoscopic Transnasal Resection of Suprasellar Teratoma. 61
30708386 2019
44
Retroperitoneal Germ Cell Tumor Resection with Primary Inferior Vena Cava Reconstruction. 61
31275484 2019
45
Mixed germ cell tumor of metastatic undescended testicle causing major GIS bleeding. 61
31211078 2019
46
Mixed germ cell tumor composed of a tridermic testicular teratoma and seminoma in a rooster. 61
30862303 2019
47
Testicular mixed germ cell tumor presenting with seizure as the initial symptom: a case report and literature review. 61
30912892 2019
48
Testicular Mixed Germ Cell Tumor in a Newborn Child: A Rare Case. 61
31105405 2019
49
Mediastinal mixed germ cell tumor with splenic histiocytosis: A rare coincidence. 61
30971575 2019
50
Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases. 61
30557172 2019

Variations for Mixed Germ Cell Tumor

Expression for Mixed Germ Cell Tumor

Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

GO Terms for Mixed Germ Cell Tumor

Cellular components related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 KIT CGB3 CGA AFP

Biological processes related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone processing GO:0016486 8.62 CGB3 CGA

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGB3 CGA

Sources for Mixed Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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