MCID: MXD032
MIFTS: 34

Mixed Germ Cell Tumor

Categories: Rare diseases

Aliases & Classifications for Mixed Germ Cell Tumor

MalaCards integrated aliases for Mixed Germ Cell Tumor:

Name: Mixed Germ Cell Tumor 59 73

Classifications:



External Ids:

Orphanet 59 ORPHA180234
UMLS via Orphanet 74 C0334524

Summaries for Mixed Germ Cell Tumor

MalaCards based summary : Mixed Germ Cell Tumor is related to polyembryoma and endodermal sinus tumor. An important gene associated with Mixed Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Peptide hormone metabolism and Glucocorticoid receptor regulatory network. The drugs Lenograstim and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testis.

Related Diseases for Mixed Germ Cell Tumor

Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 polyembryoma 30.4 AFP CGA
2 endodermal sinus tumor 29.7 AFP CGB3
3 embryonal carcinoma 29.4 AFP KIT
4 choriocarcinoma 29.4 CGA CGB3
5 teratoma 28.2 AFP CGA CGB3 KIT
6 seminoma 27.3 AFP CGA CGB3 KIT
7 mixed germ cell tumor of central nervous system 12.2
8 childhood testicular mixed germ cell tumor 12.2
9 childhood central nervous system mixed germ cell tumor 12.2
10 adult central nervous system mixed germ cell tumor 12.2
11 ovarian mixed germ cell neoplasm 11.6
12 mixed germ cell cancer 11.2
13 teratocarcinoma 11.1
14 germ cells tumors 10.9
15 mature teratoma 10.2
16 mediastinitis 10.1
17 hepatic angiomyolipoma 10.1 AFP KIT
18 intratubular embryonal carcinoma 10.1 AFP KIT
19 endometrial small cell carcinoma 10.1 AFP KIT
20 rete testis adenocarcinoma 10.1 AFP KIT
21 testicular infarct 10.1 AFP KIT
22 mediastinal cancer 10.1 AFP KIT
23 rete testis neoplasm 10.1 AFP KIT
24 extragonadal seminoma 10.0 AFP KIT
25 sacrococcygeal teratoma 10.0 AFP CGA
26 triploidy 10.0 AFP CGA
27 trophoblastic neoplasm 10.0
28 gonadoblastoma 10.0
29 dysgerminoma of ovary 10.0 AFP KIT
30 orofaciodigital syndrome viii 10.0 AFP CGA
31 hydrocele 9.9 AFP CGA
32 growing teratoma syndrome 9.9
33 testicular microlithiasis 9.9
34 pancreatitis 9.9
35 leukemia 9.9
36 epithelioid trophoblastic tumor 9.9
37 precocious puberty 9.9
38 testicular germ cell tumor 9.9 AFP KIT
39 cell type cancer 9.9 AFP KIT
40 gastrointestinal system cancer 9.8 AFP KIT
41 adrenocortical carcinoma, hereditary 9.8
42 gonadal dysgenesis 9.8
43 pituitary adenoma 9.8
44 cowden disease 9.8
45 headache 9.8
46 hemangiopericytoma, malignant 9.8
47 prostatitis 9.8
48 craniopharyngioma 9.8
49 adenoma 9.8
50 neuroblastoma 9.8

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to Mixed Germ Cell Tumor

Symptoms & Phenotypes for Mixed Germ Cell Tumor

Drugs & Therapeutics for Mixed Germ Cell Tumor

Drugs for Mixed Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3,Phase 1,Phase 2 135968-09-1
2
Cisplatin Approved Phase 3,Phase 1,Phase 2 15663-27-1 84093 441203 2767
3
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
4
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
5
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
8
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
9
Ribavirin Approved Phase 3 36791-04-5 37542
10
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
11
Captopril Approved Phase 3 62571-86-2 44093
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
13
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
14
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
15
Cyclophosphamide Approved, Investigational Phase 3,Phase 1 50-18-0, 6055-19-2 2907
16
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
17
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
18
Ondansetron Approved Phase 3 99614-02-5 4595
19
Palivizumab Approved, Investigational Phase 3 188039-54-5
20
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
21
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
22
Promethazine Approved, Investigational Phase 3 60-87-7 4927
23 Dexamethasone acetate Phase 3,Phase 1,Phase 2 1177-87-3
24
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
25 Alkylating Agents Phase 3,Phase 1,Phase 2
26 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
27 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
28 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
29 Anti-Infective Agents Phase 3,Phase 1,Phase 2
30 BB 1101 Phase 3,Phase 1,Phase 2
31 Antimetabolites Phase 3,Phase 1,Phase 2
32 Antiviral Agents Phase 3,Phase 1,Phase 2
33 Antimitotic Agents Phase 3,Phase 1,Phase 2
34 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
35 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
36
Hydroxyitraconazole Phase 3
37
protease inhibitors Phase 3,Phase 1
38 Gastrointestinal Agents Phase 3,Phase 1
39 Steroid Synthesis Inhibitors Phase 3
40 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
41 Cytochrome P-450 CYP3A Inhibitors Phase 3
42 HIV Protease Inhibitors Phase 3,Phase 1
43 Cytochrome P-450 Enzyme Inhibitors Phase 3
44 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
45 Hormone Antagonists Phase 3,Phase 1,Phase 2
46 Hormones Phase 3,Phase 1,Phase 2
47 Angiotensin-Converting Enzyme Inhibitors Phase 3
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
49 Echinocandins Phase 3
50 Emetics Phase 3

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
7 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
8 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
16 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
17 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
18 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
19 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
20 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
21 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
22 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
23 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
24 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
25 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
26 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
27 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
28 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
29 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
30 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
31 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
32 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
33 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
34 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
35 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
36 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
37 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
38 Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

Anatomical Context for Mixed Germ Cell Tumor

MalaCards organs/tissues related to Mixed Germ Cell Tumor:

41
Brain, Bone, Testis, Ovary, Bone Marrow, Spinal Cord, Pineal

Publications for Mixed Germ Cell Tumor

Articles related to Mixed Germ Cell Tumor:

(show top 50) (show all 145)
# Title Authors Year
1
The Clinical Significance of a Small Component of Choriocarcinoma in Testicular Mixed Germ Cell Tumor (MGCT). ( 29794869 )
2018
2
Case report: Extragonadal mixed germ cell tumor in the thigh. ( 29255677 )
2018
3
Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: A case report and literature review. ( 29768344 )
2018
4
A 45,X/46,XY Male with Orchidopexy Diagnosed with Mixed Germ Cell Tumor After 21-year Follow-up. ( 28491817 )
2017
5
An unusual primary omental tumor: Mixed germ cell tumor. ( 29162411 )
2017
6
Extradural Spinal Metastasis in Ovarian Mixed Germ Cell Tumor. ( 28904580 )
2017
7
An Unusual Cause of Headache and Sudden Death of a Young Sailor-Postmortem Computed Tomography and Histological Findings of a Fatal Retroperitoneal Malignant Mixed Germ Cell Tumor. ( 29166539 )
2017
8
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature. ( 29395947 )
2017
9
Cardiac Invasion by a Mixed Germ Cell Tumor. ( 28317638 )
2017
10
Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas. ( 28429716 )
2017
11
Malignant Mixed Germ Cell Tumor Overgrowing a Gonadoblastoma in a Female With a 46, XX Karyotype: A Case Report. ( 29183227 )
2017
12
Metachronuous Synovial Sarcoma After Treatment of Mixed Germ Cell Tumor in a Child of Complet Gonodal Dysgenesis. ( 28836496 )
2017
13
Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. ( 26870146 )
2016
14
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors. ( 26548627 )
2016
15
Surgical Technique: Endoscopic Endonasal Transphenoidal Resection of a Large Suprasellar Mixed Germ Cell Tumor. ( 27014537 )
2016
16
A Case of Mixed Germ Cell Tumor in the Intramedullary Spinal-cord. ( 27628608 )
2016
17
Persistent MA1llerian duct syndrome of mixed anatomical variant (combined male and female type) with mixed germ cell tumor of left intra-abdominal testis. ( 27166045 )
2016
18
Development of CNS-type Primitive Neuroectodermal Tumor in Metastatic Testicular Mixed Germ Cell Tumor. ( 27169016 )
2016
19
A variant c-KIT mutation, D816H, fundamental to the sequential development of an ovarian mixed germ cell tumor and systemic mastocytosis with chronic myelomonocytic leukemia. ( 27781377 )
2016
20
Ovarian Malignant Mixed Germ Cell Tumor: A Case of Unusual Presentation as Molar Pregnancy. ( 27141469 )
2016
21
Ovarian malignant mixed germ cell tumor: A rare combination with five germ cell components. ( 26960658 )
2016
22
Human Hemochromatosis Protein (HFE) Immunoperoxidase Stain Highlights Choriocarcinoma within Mixed Germ Cell Tumors. ( 27034532 )
2016
23
Massive pericardial effusion due to intrapericardial mixed germ cell tumor in a premature baby. ( 26147709 )
2015
24
Mediastinal mixed germ cell tumor in an infertile male with Klinefelter syndrome:A case report and literature review. ( 26881632 )
2015
25
Mixed germ cell tumor in a teenager: A rare entity. ( 26905172 )
2015
26
Pelvic and right ovarian mature teratomas with malignant mixed germ cell tumors of the anterior abdominal wall. ( 25794818 )
2015
27
Mixed Germ Cell Tumor of Testis with Isolated Scapular Metastasis: A Case Report and Review of the Literature. ( 26351612 )
2015
28
Testicular seminomatous mixed germ cell tumor with choriocarcinoma and teratoma with secondary somatic malignancy: a case report. ( 24380446 )
2014
29
Equine Placental Mixed Germ Cell Tumor With Metastasis to the Foal. ( 24823807 )
2014
30
Primary ovarian malignant melanoma arising in teratomatous component of mixed- germ cell tumor in a child: case report. ( 24499012 )
2014
31
Burned-out in a mixed germ cell tumor of the testis: the problem of pT0. Case report. ( 25641479 )
2014
32
A 23-year-old female with a mixed germ cell tumor of the pituitary infundibulum: the challenge of differentiating neoplasm from lymphocytic infundibuloneurohypophysitis-a case report and literature review. ( 25045548 )
2014
33
Ovarian malignant mixed germ cell tumor with clear cell carcinoma in a postmenopausal woman. ( 25674278 )
2014
34
Primary mixed germ cell tumor arising in the pancreatic head. ( 23331834 )
2013
35
Intratumoral hemorrhage because of primary spinal mixed germ cell tumor presenting with atypical radiological features in an adult. ( 23953732 )
2013
36
Ovarian mixed germ cell tumor with yolk sac and teratomatous components in a dog. ( 23604259 )
2013
37
Mixed germ cell tumor complicating an intra-abdominal cryptorchidism. ( 24176649 )
2013
38
Mixed germ cell tumor of mediastinum/lung masquerading as hemangioma in fine needle biopsy. ( 24056656 )
2013
39
Occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor containing yolk sac tumor and germinoma. ( 23082803 )
2013
40
Isolated retroperitoneal mixed germ cell tumor presenting as acute abdomen - case report. ( 23788970 )
2013
41
Atypical presentation of pediatric mixed germ cell tumors in the sellar-suprasellar region. ( 22406789 )
2012
42
Extragonadal mixed germ cell tumor of the right arm: description of the first case in the literature. ( 22540884 )
2012
43
Hematogenous extraneural metastasis of the germinomatous component of a pineal mixed germ cell tumor. ( 22286191 )
2012
44
Retroperitoneal mixed germ cell tumor mimicking a renal neoplasm: a case report. ( 22446344 )
2012
45
Postchemotherapy-related changes in mediastinal mixed germ cell tumor masquerading as a vascular neoplasm. ( 23455797 )
2012
46
A rare case of bilateral massive hemothorax from spontaneous rupture of a primary mediastinal mixed germ cell tumor. ( 22269740 )
2012
47
Mixed germ cell tumor of ovary and clitoromegaly in Swyer's syndrome: a case report. ( 22773216 )
2012
48
A^a8,F-FDG PET/CT imaging for mixed germ cell tumor in the pineal region. ( 22310274 )
2012
49
Mixed germ cell tumor with extensive yolk sac tumor elements in the frontal lobe of an adult. ( 23326746 )
2012
50
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. ( 21519041 )
2011

Variations for Mixed Germ Cell Tumor

Expression for Mixed Germ Cell Tumor

Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

GO Terms for Mixed Germ Cell Tumor

Biological processes related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.33 CGA CGB3 KIT
2 positive regulation of cell migration GO:0030335 8.96 CGA KIT
3 peptide hormone processing GO:0016486 8.62 CGA CGB3

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGA CGB3

Sources for Mixed Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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