MCID: MXD026
MIFTS: 35

Mixed Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Mixed Glioma

MalaCards integrated aliases for Mixed Glioma:

Name: Mixed Glioma 12 55 15
Mixed Gliomas 12 73
Glioma 44 73
Mixed Neuroglial Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5076
MeSH 44 D005910
NCIt 50 C3903
SNOMED-CT 68 22217002 443937008

Summaries for Mixed Glioma

MalaCards based summary : Mixed Glioma, also known as mixed gliomas, is related to glioma susceptibility 1 and glioma. An important gene associated with Mixed Glioma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Central carbon metabolism in cancer. The drugs Gliadel Wafer and Dacarbazine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells.

Related Diseases for Mixed Glioma

Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 29.8 IDH1 TP53
2 glioma 29.7 IDH1 PDGFRA TP53
3 oligodendroglioma 29.0 GFAP IDH1 PDGFRA TP53
4 glioblastoma 28.6 IDH1 PDGFRA TP53
5 glioblastoma multiforme 28.6 GFAP IDH1 PDGFRA TP53
6 adult brainstem mixed glioma 12.1
7 oligoastrocytoma 11.5
8 anaplastic oligoastrocytoma 11.0
9 mixed oligodendroglioma-astrocytoma 11.0
10 frontal convexity meningioma 10.6 GFAP TP53
11 gliofibroma 10.6 GFAP TP53
12 cerebral convexity meningioma 10.6 GFAP TP53
13 protoplasmic astrocytoma 10.6 GFAP TP53
14 cellular ependymoma 10.6 GFAP TP53
15 central nervous system primitive neuroectodermal neoplasm 10.6 GFAP TP53
16 cerebral neuroblastoma 10.6 GFAP TP53
17 spinal cancer 10.6 GFAP TP53
18 ependymoblastoma 10.6 GFAP TP53
19 cerebral ventricle cancer 10.6 GFAP TP53
20 cerebrum cancer 10.6 GFAP TP53
21 chordoid glioma 10.6 GFAP TP53
22 supratentorial cancer 10.6 GFAP TP53
23 malignant ependymoma 10.6 GFAP TP53
24 papilloma of choroid plexus 10.5 GFAP TP53
25 choroid plexus cancer 10.5 GFAP TP53
26 necrotizing sialometaplasia 10.5 GFAP TP53
27 cystic teratoma 10.5 GFAP TP53
28 cerebellar liponeurocytoma 10.5 GFAP TP53
29 medullomyoblastoma 10.5 GFAP TP53
30 brain glioma 10.5 GFAP TP53
31 juvenile pilocytic astrocytoma 10.5 GFAP TP53
32 clear cell ependymoma 10.5 GFAP TP53
33 optic nerve glioma 10.4 GFAP TP53
34 infratentorial cancer 10.4 GFAP TP53
35 ganglioglioma 10.4 GFAP TP53
36 breast malignant phyllodes tumor 10.4 AGO2 TP53
37 atypical teratoid rhabdoid tumor 10.3 GFAP TP53
38 extraventricular neurocytoma 10.3 GFAP IDH1
39 neurilemmoma 10.3 GFAP PDGFRA
40 dysembryoplastic neuroepithelial tumor 10.3 GFAP IDH1
41 intracranial chondrosarcoma 10.3 IDH1 TP53
42 cerebellar astrocytoma 10.3 IDH1 TP53
43 angiocentric glioma 10.3 GFAP IDH1
44 childhood oligodendroglioma 10.3 GFAP IDH1
45 small cell carcinoma 10.2 PDGFRA TP53
46 periosteal osteogenic sarcoma 10.2 IDH1 TP53
47 cerebellopontine angle tumor 10.2 GFAP IDH1
48 undifferentiated pleomorphic sarcoma 10.2 IDH1 PDGFRA
49 brain stem glioma 10.2 IDH1 TP53
50 grade iii astrocytoma 10.2 GFAP PDGFRA TP53

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to Mixed Glioma

Symptoms & Phenotypes for Mixed Glioma

Drugs & Therapeutics for Mixed Glioma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Gliadel Wafer 18 49 CARMUSTINE Rhone-Poulenc Rorer, Guilford Pharmaceuticals February 1997

Drugs for Mixed Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 249)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Vincristine Approved, Investigational Phase 3,Phase 1 2068-78-2, 57-22-7 5978
5
Procarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 671-16-9 4915
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
7
Lomustine Approved, Investigational Phase 3,Phase 1 13010-47-4 3950
8
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
9
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Carmustine Approved, Investigational Phase 3,Phase 2,Phase 1 154-93-8 2578
13
Trioxsalen Approved Phase 3,Phase 2,Phase 1 3902-71-4 5585
14
Dopamine Approved Phase 3,Not Applicable 51-61-6, 62-31-7 681
15
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
16
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
17
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538 444795
18 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
19 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Early Phase 1
21 Ether Phase 3,Phase 2,Phase 1
22 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3
23 Analgesics Phase 3,Phase 2,Phase 1
24 Central Nervous System Depressants Phase 3,Phase 2
25 Adjuvants, Anesthesia Phase 3
26 Central Nervous System Stimulants Phase 3,Phase 2
27 Cholinergic Agents Phase 3,Phase 2
28 Cholinesterase Inhibitors Phase 3,Phase 2
29 Gastrointestinal Agents Phase 3,Phase 2,Phase 1,Not Applicable
30 Narcotics Phase 3
31 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
32 Hematoporphyrin Derivative Phase 3,Phase 2,Phase 1
33 Hematoporphyrins Phase 3,Phase 2,Phase 1
34 Analgesics, Opioid Phase 3
35 Anesthetics Phase 3
36 Nootropic Agents Phase 3,Phase 2
37 Anesthetics, General Phase 3
38 Dermatologic Agents Phase 3,Phase 2,Phase 1
39 Anesthetics, Inhalation Phase 3
40 Anesthetics, Intravenous Phase 3
41 Dihematoporphyrin Ether Phase 3,Phase 2,Phase 1
42 Emetics Phase 3,Phase 2
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
44 Photosensitizing Agents Phase 3,Phase 2,Phase 1
45 Antiemetics Phase 3,Phase 2,Phase 1
46 Liver Extracts Phase 3,Phase 2,Phase 1
47 BB 1101 Phase 3,Phase 2,Phase 1
48 Autonomic Agents Phase 3,Phase 1
49 Antimitotic Agents Phase 3,Phase 1
50 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 183)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas Completed NCT00004259 Phase 3 BCNU 80mg/m2;TMZ 200mg/m2;CCNU;BCNU 150mg/m2;BCNU 200mg/m2;TMZ 150mg/m2 six 6-week cycles;TMZ 150mg/m2 six 8-week cycles
2 Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
3 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3 temozolomide
4 Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
5 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3 porfimer sodium
6 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
8 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
9 Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
10 Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00978458 Phase 3 temozolomide
11 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
12 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
13 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
14 Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Mixed Gliomas Completed NCT00003473 Phase 2 Atengenal;Astugenal
15 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy Completed NCT00004868 Phase 1, Phase 2 semaxanib
16 Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma Completed NCT00400816 Phase 2 temozolomide
17 Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors Completed NCT00003731 Phase 2 temozolomide
18 Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas Completed NCT00033280 Phase 2 temozolomide
19 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
20 Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse Completed NCT00003775 Phase 2 leflunomide
21 Topotecan in Treating Patients With Recurrent Brain Tumors Completed NCT00003372 Phase 2 topotecan hydrochloride
22 Temozolomide, Thalidomide, and Celecoxib Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00047294 Phase 2 celecoxib;temozolomide;thalidomide
23 Fenretinide in Treating Patients With Recurrent Malignant Glioma Completed NCT00006080 Phase 2 fenretinide
24 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2 temozolomide
25 Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma Completed NCT00058123 Phase 2 poly ICLC
26 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
27 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
28 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Completed NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
29 Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme Completed NCT01648348 Phase 1, Phase 2
30 Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Completed NCT01462695 Phase 2 Sunitinib Malate
31 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
32 Sunitinib in Treating Patients With Recurrent Malignant Gliomas Completed NCT00499473 Phase 2 sunitinib malate
33 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
34 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
35 Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma Completed NCT00124657 Phase 1, Phase 2 Erlotinib hydrochloride
36 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
37 Temozolomide in Treating Patients With Recurrent High-Grade Glioma Completed NCT00619112 Phase 2 temozolomide
38 Carmustine Plus O6-benzylguanine in Treating Patients With Recurrent or Progressive Glioma Completed NCT00005081 Phase 2 O6-benzylguanine;carmustine
39 Temozolomide and Carmustine in Treating Patients With Anaplastic Glioma Completed NCT00003176 Phase 2 carmustine;temozolomide
40 Immunotoxin Therapy in Treating Patients With Malignant Glioma Completed NCT00006268 Phase 1, Phase 2 isolated perfusion
41 Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) With Bevacizumab and Irinotecan for Malignant Glioma Completed NCT00352521 Phase 2 bevacizumab;irinotecan
42 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
43 ATN-161 and Carboplatin in Treating Patients With Recurrent Malignant Glioma Completed NCT00352313 Phase 1, Phase 2 ATN-161;carboplatin
44 Study of Capecitabine to Treat Recurrent High Grade Gliomas Completed NCT00717197 Phase 2 Capecitabine
45 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
46 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
47 Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma Completed NCT00795665 Phase 2 bevacizumab;carmustine
48 Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma Completed NCT00047281 Phase 2 celecoxib;cyclophosphamide;etoposide;thalidomide
49 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
50 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride

Search NIH Clinical Center for Mixed Glioma

Cochrane evidence based reviews: glioma

Genetic Tests for Mixed Glioma

Anatomical Context for Mixed Glioma

MalaCards organs/tissues related to Mixed Glioma:

41
Brain, Bone, T Cells, Bone Marrow, Liver, Spinal Cord, Endothelial

Publications for Mixed Glioma

Articles related to Mixed Glioma:

(show all 13)
# Title Authors Year
1
Mixed Glioma (Oligoastrocytoma) in the Brain ofA an African Hedgehog (Atelerix albiventris). ( 25172052 )
2014
2
Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? ( 25359109 )
2014
3
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. ( 17252186 )
2007
4
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. ( 12889176 )
2003
5
Long-term outcome of low-grade oligodendroglioma and mixed glioma. ( 10751254 )
2000
6
Exophytic malignant brainstem mixed glioma in an adult: a case report. ( 9524090 )
1998
7
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. ( 9524101 )
1998
8
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. ( 3713193 )
1986
9
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. ( 3748360 )
1986
10
Mixed glioma of the cerebellopontine angle. ( 3878094 )
1985
11
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. ( 6286891 )
1982
12
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. ( 929897 )
1977
13
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. ( 5050901 )
1972

Variations for Mixed Glioma

Expression for Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for Mixed Glioma

Pathways related to Mixed Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 PDGFRA TP53
2 10.61 IDH1 PDGFRA TP53

GO Terms for Mixed Glioma

Biological processes related to Mixed Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female gonad development GO:0008585 8.62 IDH1 PDGFRA

Sources for Mixed Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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