MCID: MXD003
MIFTS: 31

Mixed Lacrimal Gland Cancer

Categories: Cancer diseases, Neuronal diseases, Eye diseases, Endocrine diseases

Aliases & Classifications for Mixed Lacrimal Gland Cancer

MalaCards integrated aliases for Mixed Lacrimal Gland Cancer:

Name: Mixed Lacrimal Gland Cancer 12 15
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland 12
Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland 12
Malignant Mixed Neoplasm of Lacrimal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:296
NCIt 50 C6804
SNOMED-CT 68 254989000
UMLS 73 C0346342

Summaries for Mixed Lacrimal Gland Cancer

MalaCards based summary : Mixed Lacrimal Gland Cancer, also known as carcinoma ex pleomorphic adenoma of the lacrimal gland, is related to pleomorphic adenoma carcinoma and pleomorphic adenoma. An important gene associated with Mixed Lacrimal Gland Cancer is TYK2 (Tyrosine Kinase 2), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Affiliated tissues include eye, and related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection and adipose tissue

Related Diseases for Mixed Lacrimal Gland Cancer

Diseases related to Mixed Lacrimal Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 pleomorphic adenoma carcinoma 10.5
2 pleomorphic adenoma 10.5
3 adenoma 10.5
4 myoepithelioma 10.1
5 epithelial-myoepithelial carcinoma 10.1
6 hyperimmunoglobulin syndrome 9.8 STAT3 TYK2
7 hyper-ige recurrent infection syndrome, autosomal dominant 9.8 STAT3 TYK2
8 hyper ige syndrome 9.8 STAT3 TYK2
9 chronic mucocutaneous candidiasis 9.8 IL6 STAT3
10 intestinal disease 9.7 IL6 STAT3
11 gastrointestinal system cancer 9.6 IL6 STAT3
12 bone marrow cancer 9.6 IL6 TYK2
13 mouth disease 9.4 IL6 JAK1
14 kaposi sarcoma 9.2 IL6 STAT3
15 polycythemia vera 8.9 JAK1 STAT3 TYK2
16 hepatitis c 8.9 JAK1 STAT3 TYK2

Graphical network of the top 20 diseases related to Mixed Lacrimal Gland Cancer:



Diseases related to Mixed Lacrimal Gland Cancer

Symptoms & Phenotypes for Mixed Lacrimal Gland Cancer

GenomeRNAi Phenotypes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 8.62 JAK1 TYK2

MGI Mouse Phenotypes related to Mixed Lacrimal Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 IL6 STAT3 TYK2
2 skeleton MP:0005390 8.92 IL6 JAK1 STAT3 TYK2

Drugs & Therapeutics for Mixed Lacrimal Gland Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Lacrimal Gland Cancer

Genetic Tests for Mixed Lacrimal Gland Cancer

Anatomical Context for Mixed Lacrimal Gland Cancer

MalaCards organs/tissues related to Mixed Lacrimal Gland Cancer:

41
Eye

Publications for Mixed Lacrimal Gland Cancer

Articles related to Mixed Lacrimal Gland Cancer:

# Title Authors Year
1
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
2
Comprehensive management of a rare carcinoma ex pleomorphic adenoma of the lacrimal gland with a modified lateral orbitotomy access osteotomy. A case report. ( 21445559 )
2012
3
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 18369704 )
2008
4
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. ( 17881995 )
2007
5
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 17416946 )
2006

Variations for Mixed Lacrimal Gland Cancer

Expression for Mixed Lacrimal Gland Cancer

Search GEO for disease gene expression data for Mixed Lacrimal Gland Cancer.

Pathways for Mixed Lacrimal Gland Cancer

Pathways related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 IL6 JAK1 STAT3 TYK2
2
Show member pathways
13.08 IL6 JAK1 STAT3 TYK2
3
Show member pathways
12.81 IL6 JAK1 STAT3 TYK2
4
Show member pathways
12.73 IL6 JAK1 TYK2
5
Show member pathways
12.71 IL6 JAK1 TYK2
6
Show member pathways
12.68 IL6 JAK1 STAT3 TYK2
7
Show member pathways
12.62 IL6 JAK1 STAT3
8 12.59 IL6 JAK1 STAT3
9
Show member pathways
12.59 IL6 JAK1 STAT3 TYK2
10
Show member pathways
12.54 IL6 JAK1 STAT3
11
Show member pathways
12.43 IL6 JAK1 STAT3 TYK2
12
Show member pathways
12.42 IL6 JAK1 STAT3 TYK2
13
Show member pathways
12.39 IL6 JAK1 STAT3 TYK2
14 12.36 JAK1 STAT3 TYK2
15
Show member pathways
12.25 JAK1 STAT3 TYK2
16
Show member pathways
12.2 IL6 JAK1 STAT3 TYK2
17
Show member pathways
12.16 IL6 JAK1 STAT3
18 12.13 JAK1 STAT3 TYK2
19
Show member pathways
12.09 JAK1 STAT3 TYK2
20
Show member pathways
12.06 JAK1 STAT3 TYK2
21
Show member pathways
12.06 JAK1 STAT3 TYK2
22
Show member pathways
12.04 IL6 JAK1 STAT3 TYK2
23 12.03 IL6 JAK1 STAT3
24
Show member pathways
12.03 JAK1 STAT3 TYK2
25
Show member pathways
11.98 IL6 JAK1 STAT3 TYK2
26
Show member pathways
11.95 IL6 JAK1
27 11.95 JAK1 STAT3
28
Show member pathways
11.94 JAK1 STAT3
29 11.92 JAK1 STAT3 TYK2
30
Show member pathways
11.91 JAK1 STAT3
31
Show member pathways
11.89 IL6 STAT3
32 11.87 JAK1 STAT3
33
Show member pathways
11.87 IL6 JAK1 STAT3
34
Show member pathways
11.86 IL6 STAT3
35
Show member pathways
11.85 JAK1 STAT3
36 11.84 IL6 STAT3
37 11.84 IL6 STAT3
38 11.82 JAK1 TYK2
39
Show member pathways
11.77 STAT3 TYK2
40
Show member pathways
11.75 IL6 STAT3
41
Show member pathways
11.75 IL6 JAK1 STAT3
42 11.71 IL6 STAT3
43 11.7 IL6 STAT3
44 11.61 IL6 JAK1 STAT3 TYK2
45 11.57 IL6 JAK1 STAT3 TYK2
46 11.53 JAK1 STAT3
47 11.51 JAK1 STAT3 TYK2
48 11.46 JAK1 STAT3
49 11.46 IL6 JAK1 STAT3
50 11.41 IL6 JAK1 STAT3

GO Terms for Mixed Lacrimal Gland Cancer

Cellular components related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.62 JAK1 TYK2

Biological processes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.73 JAK1 STAT3 TYK2
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.57 JAK1 TYK2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 IL6 STAT3
4 type I interferon signaling pathway GO:0060337 9.54 JAK1 TYK2
5 peptidyl-tyrosine autophosphorylation GO:0038083 9.52 JAK1 TYK2
6 interleukin-12-mediated signaling pathway GO:0035722 9.51 JAK1 TYK2
7 acute-phase response GO:0006953 9.49 IL6 STAT3
8 interleukin-7-mediated signaling pathway GO:0038111 9.48 JAK1 STAT3
9 regulation of type I interferon-mediated signaling pathway GO:0060338 9.46 JAK1 TYK2
10 cytokine-mediated signaling pathway GO:0019221 9.46 IL6 JAK1 STAT3 TYK2
11 interleukin-15-mediated signaling pathway GO:0035723 9.43 JAK1 STAT3
12 interleukin-35-mediated signaling pathway GO:0070757 9.4 JAK1 STAT3
13 interleukin-23-mediated signaling pathway GO:0038155 9.37 STAT3 TYK2
14 interleukin-21-mediated signaling pathway GO:0038114 9.32 JAK1 STAT3
15 T-helper 17 cell lineage commitment GO:0072540 9.26 IL6 STAT3
16 interleukin-6-mediated signaling pathway GO:0070102 9.13 IL6 JAK1 STAT3
17 interleukin-27-mediated signaling pathway GO:0070106 8.8 JAK1 STAT3 TYK2

Molecular functions related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.26 JAK1 STAT3
2 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.16 JAK1 TYK2
3 growth hormone receptor binding GO:0005131 8.96 JAK1 TYK2
4 CCR5 chemokine receptor binding GO:0031730 8.62 JAK1 STAT3

Sources for Mixed Lacrimal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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