MCID: MXD003
MIFTS: 30

Mixed Lacrimal Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Mixed Lacrimal Gland Cancer

MalaCards integrated aliases for Mixed Lacrimal Gland Cancer:

Name: Mixed Lacrimal Gland Cancer 12 15
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland 12
Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland 12
Malignant Mixed Neoplasm of Lacrimal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:296
NCIt 50 C6804
SNOMED-CT 67 254989000
UMLS 70 C0346342

Summaries for Mixed Lacrimal Gland Cancer

MalaCards based summary : Mixed Lacrimal Gland Cancer, also known as carcinoma ex pleomorphic adenoma of the lacrimal gland, is related to pleomorphic adenoma carcinoma and pleomorphic adenoma. An important gene associated with Mixed Lacrimal Gland Cancer is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Mixed Lacrimal Gland Cancer

Diseases related to Mixed Lacrimal Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 pleomorphic adenoma carcinoma 10.9
2 pleomorphic adenoma 10.9
3 adenoma 10.9
4 rare tumor 10.5
5 optic nerve disease 10.3
6 cystadenocarcinoma 10.3
7 mucoepidermoid carcinoma 10.3
8 myoepithelial carcinoma 10.3
9 epithelial-myoepithelial carcinoma 10.3
10 orbital disease 10.3
11 exophthalmos 10.3
12 bone squamous cell carcinoma 10.1 TYK2 STAT3
13 breast implant-associated anaplastic large cell lymphoma 10.0 STAT3 JAK1
14 chronic leukemia 10.0 STAT3 JAK2
15 lymphoblastic leukemia, acute, with lymphomatous features 10.0 JAK2 JAK1
16 wernicke encephalopathy 10.0 JAK2 JAK1
17 candidiasis 9.9 STAT3 IL6
18 spherocytosis, type 5 9.9 STAT3 IL6
19 opportunistic mycosis 9.9 STAT3 IL6
20 colonic benign neoplasm 9.9 STAT3 IL6
21 fungal infectious disease 9.9 STAT3 IL6
22 neutrophilia, hereditary 9.9 JAK2 IL6
23 b cell deficiency 9.9 STAT3 IL6
24 ileitis 9.8 STAT3 IL6
25 central retinal vein occlusion 9.8 JAK2 IL6
26 hepatic vascular disease 9.8 JAK2 IL6
27 hepatic encephalopathy 9.8 STAT3 IL6
28 vein disease 9.8 JAK2 IL6
29 intestinal benign neoplasm 9.8 STAT3 IL6
30 cutaneous lupus erythematosus 9.8 TYK2 IL6
31 atrophic gastritis 9.8 STAT3 IL6
32 autoimmune disease of gastrointestinal tract 9.8 STAT3 IL6
33 gastrointestinal system benign neoplasm 9.8 STAT3 IL6
34 myeloproliferative neoplasm 9.8 TYK2 STAT3 JAK2
35 toxoplasmosis 9.8 STAT3 IL6
36 thrombocytosis 9.8 JAK2 IL6
37 immunodeficiency 35 9.7 TYK2 STAT3 JAK1
38 mastocytosis 9.7 JAK2 IL6
39 hepatitis c 9.7 TYK2 STAT3 JAK1
40 hepatitis 9.7 TYK2 STAT3 JAK1
41 myelofibrosis 9.7 STAT3 JAK2 JAK1
42 fibrosarcoma 9.7 TYK2 JAK2 JAK1
43 hyper ige recurrent infection syndrome 1 9.6 TYK2 STAT3 IL6
44 nail disease 9.6 TYK2 STAT3 IL6
45 hyper ige syndrome 9.6 TYK2 STAT3 IL6
46 chronic mucocutaneous candidiasis 9.6 TYK2 STAT3 IL6
47 essential thrombocythemia 9.6 STAT3 JAK2 IL6
48 leptin deficiency or dysfunction 9.6 STAT3 JAK2 IL6
49 leukocyte disease 9.6 STAT3 IL6
50 sarcoma 9.6 STAT3 JAK2 IL6

Graphical network of the top 20 diseases related to Mixed Lacrimal Gland Cancer:



Diseases related to Mixed Lacrimal Gland Cancer

Symptoms & Phenotypes for Mixed Lacrimal Gland Cancer

GenomeRNAi Phenotypes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.36 TYK2
2 Decreased viability GR00055-A-2 9.36 TYK2
3 Decreased viability GR00055-A-3 9.36 TYK2
4 Decreased viability GR00221-A-1 9.36 TYK2
5 Decreased viability GR00221-A-2 9.36 JAK1 JAK2 TYK2
6 Decreased viability GR00221-A-3 9.36 TYK2
7 Decreased viability GR00221-A-4 9.36 TYK2
8 Decreased viability GR00249-S 9.36 JAK1
9 Decreased viability GR00381-A-1 9.36 TYK2

MGI Mouse Phenotypes related to Mixed Lacrimal Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.72 IL6 JAK1 JAK2 STAT3 TYK2
2 immune system MP:0005387 9.65 IL6 JAK1 JAK2 STAT3 TYK2
3 liver/biliary system MP:0005370 9.46 IL6 JAK1 JAK2 STAT3
4 respiratory system MP:0005388 9.26 IL6 JAK1 JAK2 STAT3
5 skeleton MP:0005390 9.02 IL6 JAK1 JAK2 STAT3 TYK2

Drugs & Therapeutics for Mixed Lacrimal Gland Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Lacrimal Gland Cancer

Genetic Tests for Mixed Lacrimal Gland Cancer

Anatomical Context for Mixed Lacrimal Gland Cancer

Publications for Mixed Lacrimal Gland Cancer

Articles related to Mixed Lacrimal Gland Cancer:

(show all 14)
# Title Authors PMID Year
1
Re: "Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland". 61
33661769 2021
2
Reply re: "Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland". 61
33661770 2021
3
Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland. 61
33172316 2020
4
Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland. 61
32282452 2020
5
Invasive Carcinoma Ex-Pleomorphic Adenoma of the Lacrimal Gland with a Cystadenocarcinoma Component: A Case Report and Review of the Literature. 61
32850170 2020
6
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. 61
26934566 2017
7
The interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the lacrimal gland. 61
27286739 2016
8
Mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland: a rare presentation. 61
25005213 2014
9
Comprehensive management of a rare carcinoma ex pleomorphic adenoma of the lacrimal gland with a modified lateral orbitotomy access osteotomy. A case report. 61
21445559 2012
10
Malignant mixed tumor of the lacrimal gland in a teenager. 61
20210279 2011
11
Epithelial tumors of the lacrimal gland: an update. 61
18772674 2008
12
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. 61
18369704 2008
13
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. 61
17881995 2007
14
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. 61
17416946 2006

Variations for Mixed Lacrimal Gland Cancer

Expression for Mixed Lacrimal Gland Cancer

Search GEO for disease gene expression data for Mixed Lacrimal Gland Cancer.

Pathways for Mixed Lacrimal Gland Cancer

Pathways related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TYK2 STAT3 JAK2 JAK1 IL6
2
Show member pathways
13.34 TYK2 STAT3 JAK2 JAK1 IL6
3
Show member pathways
13.2 STAT3 JAK2 JAK1 IL6
4
Show member pathways
13.19 TYK2 STAT3 JAK2 JAK1 IL6
5
Show member pathways
13.05 TYK2 STAT3 JAK2 JAK1 IL6
6
Show member pathways
12.91 TYK2 STAT3 JAK2 JAK1 IL6
7
Show member pathways
12.85 TYK2 JAK2 JAK1 IL6
8
Show member pathways
12.8 TYK2 STAT3 JAK2 JAK1 IL6
9
Show member pathways
12.74 STAT3 JAK2 JAK1 IL6
10 12.72 STAT3 JAK2 JAK1 IL6
11
Show member pathways
12.71 STAT3 JAK2 JAK1
12
Show member pathways
12.7 STAT3 JAK2 JAK1
13
Show member pathways
12.7 TYK2 STAT3 JAK2 JAK1 IL6
14 12.69 TYK2 JAK2 JAK1 IL6
15
Show member pathways
12.66 TYK2 STAT3 JAK2 JAK1 IL6
16
Show member pathways
12.53 STAT3 JAK2 JAK1 IL6
17
Show member pathways
12.52 STAT3 JAK2 JAK1 IL6
18
Show member pathways
12.49 TYK2 STAT3 JAK2 JAK1 IL6
19 12.48 TYK2 STAT3 JAK2 JAK1
20
Show member pathways
12.48 TYK2 STAT3 JAK2 JAK1 IL6
21
Show member pathways
12.4 TYK2 JAK2 JAK1
22
Show member pathways
12.38 STAT3 JAK2 JAK1
23
Show member pathways
12.36 STAT3 JAK2 JAK1
24
Show member pathways
12.34 TYK2 STAT3 JAK2 JAK1
25
Show member pathways
12.32 TYK2 STAT3 JAK2 JAK1 IL6
26
Show member pathways
12.29 STAT3 JAK2 JAK1
27
Show member pathways
12.28 TYK2 STAT3 JAK2 JAK1
28
Show member pathways
12.27 STAT3 JAK2 JAK1 IL6
29
Show member pathways
12.26 STAT3 JAK2 JAK1
30
Show member pathways
12.23 TYK2 STAT3 JAK2 JAK1
31
Show member pathways
12.2 JAK2 JAK1 IL6
32
Show member pathways
12.19 TYK2 STAT3 JAK2 JAK1
33 12.16 TYK2 JAK1 IL6
34 12.15 JAK2 JAK1 IL6
35
Show member pathways
12.14 TYK2 STAT3 JAK2 JAK1
36
Show member pathways
12.12 TYK2 JAK1 IL6
37 12.11 STAT3 JAK1 IL6
38
Show member pathways
12.11 JAK2 JAK1 IL6
39 12.11 STAT3 JAK2 JAK1
40
Show member pathways
12.09 STAT3 JAK2 JAK1
41 12.04 STAT3 JAK2 JAK1
42
Show member pathways
12.01 STAT3 JAK2 JAK1
43
Show member pathways
11.92 TYK2 STAT3 JAK2
44 11.86 STAT3 JAK2 IL6
45
Show member pathways
11.85 STAT3 JAK2 JAK1 IL6
46
Show member pathways
11.84 STAT3 JAK2 JAK1
47 11.83 TYK2 JAK2 JAK1 IL6
48 11.82 TYK2 STAT3 JAK2 JAK1 IL6
49
Show member pathways
11.74 STAT3 JAK2
50 11.69 STAT3 JAK2 JAK1

GO Terms for Mixed Lacrimal Gland Cancer

Biological processes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.89 TYK2 STAT3 JAK2 JAK1
2 protein phosphorylation GO:0006468 9.85 TYK2 JAK2 JAK1
3 positive regulation of cell proliferation GO:0008284 9.84 STAT3 JAK2 IL6
4 intracellular signal transduction GO:0035556 9.82 TYK2 JAK2 JAK1
5 negative regulation of cell proliferation GO:0008285 9.82 STAT3 JAK2 IL6
6 peptidyl-tyrosine phosphorylation GO:0018108 9.72 TYK2 JAK2 JAK1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 JAK2 IL6
8 positive regulation of interleukin-6 production GO:0032755 9.67 STAT3 IL6
9 positive regulation of tumor necrosis factor production GO:0032760 9.67 STAT3 JAK2 IL6
10 modulation of chemical synaptic transmission GO:0050804 9.66 STAT3 JAK2
11 negative regulation of cell death GO:0060548 9.66 STAT3 JAK2
12 interferon-gamma-mediated signaling pathway GO:0060333 9.65 JAK2 JAK1
13 type I interferon signaling pathway GO:0060337 9.65 TYK2 JAK1
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 STAT3 JAK2 IL6
15 positive regulation of interleukin-8 production GO:0032757 9.64 STAT3 IL6
16 acute-phase response GO:0006953 9.63 STAT3 IL6
17 positive regulation of interleukin-10 production GO:0032733 9.63 STAT3 IL6
18 response to antibiotic GO:0046677 9.62 JAK2 JAK1
19 JAK-STAT cascade GO:0007259 9.62 STAT3 JAK2
20 interleukin-7-mediated signaling pathway GO:0038111 9.61 STAT3 JAK1
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.61 STAT3 IL6
22 positive regulation of interleukin-1 beta production GO:0032731 9.61 STAT3 JAK2 IL6
23 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.6 STAT3 JAK2
24 growth hormone receptor signaling pathway GO:0060396 9.58 STAT3 JAK2
25 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.58 JAK2 JAK1
26 interleukin-15-mediated signaling pathway GO:0035723 9.57 STAT3 JAK1
27 postsynapse to nucleus signaling pathway GO:0099527 9.56 STAT3 JAK2
28 cytokine-mediated signaling pathway GO:0019221 9.55 TYK2 STAT3 JAK2 JAK1 IL6
29 interleukin-9-mediated signaling pathway GO:0038113 9.54 STAT3 JAK1
30 interleukin-12-mediated signaling pathway GO:0035722 9.54 TYK2 JAK2 JAK1
31 interleukin-21-mediated signaling pathway GO:0038114 9.52 STAT3 JAK1
32 T-helper 17 cell lineage commitment GO:0072540 9.51 STAT3 IL6
33 interleukin-35-mediated signaling pathway GO:0070757 9.5 STAT3 JAK2 JAK1
34 negative regulation of primary miRNA processing GO:2000635 9.46 STAT3 IL6
35 interleukin-23-mediated signaling pathway GO:0038155 9.43 TYK2 STAT3 JAK2
36 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 9.4 STAT3 JAK2
37 interleukin-6-mediated signaling pathway GO:0070102 9.26 STAT3 JAK2 JAK1 IL6
38 interleukin-27-mediated signaling pathway GO:0070106 8.92 TYK2 STAT3 JAK2 JAK1

Molecular functions related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.54 TYK2 JAK2 JAK1
2 protein tyrosine kinase activity GO:0004713 9.5 TYK2 JAK2 JAK1
3 protein phosphatase binding GO:0019903 9.4 STAT3 JAK1
4 CCR5 chemokine receptor binding GO:0031730 9.26 STAT3 JAK1
5 type 1 angiotensin receptor binding GO:0031702 9.16 TYK2 JAK2
6 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.13 TYK2 JAK2 JAK1
7 growth hormone receptor binding GO:0005131 8.8 TYK2 JAK2 JAK1

Sources for Mixed Lacrimal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....