MCID: MXD003
MIFTS: 33

Mixed Lacrimal Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Mixed Lacrimal Gland Cancer

MalaCards integrated aliases for Mixed Lacrimal Gland Cancer:

Name: Mixed Lacrimal Gland Cancer 12 15
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland 12
Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland 12
Malignant Mixed Neoplasm of Lacrimal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:296
NCIt 50 C6804
UMLS 73 C0346342

Summaries for Mixed Lacrimal Gland Cancer

MalaCards based summary : Mixed Lacrimal Gland Cancer, also known as carcinoma ex pleomorphic adenoma of the lacrimal gland, is related to pleomorphic adenoma carcinoma and pleomorphic adenoma. An important gene associated with Mixed Lacrimal Gland Cancer is TYK2 (Tyrosine Kinase 2), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Affiliated tissues include bone, eye and colon, and related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection and adipose tissue

Related Diseases for Mixed Lacrimal Gland Cancer

Graphical network of the top 20 diseases related to Mixed Lacrimal Gland Cancer:



Diseases related to Mixed Lacrimal Gland Cancer

Symptoms & Phenotypes for Mixed Lacrimal Gland Cancer

GenomeRNAi Phenotypes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 8.62 JAK1 TYK2

MGI Mouse Phenotypes related to Mixed Lacrimal Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 IL6 STAT3 TYK2
2 skeleton MP:0005390 8.92 IL6 JAK1 STAT3 TYK2

Drugs & Therapeutics for Mixed Lacrimal Gland Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Lacrimal Gland Cancer

Genetic Tests for Mixed Lacrimal Gland Cancer

Anatomical Context for Mixed Lacrimal Gland Cancer

MalaCards organs/tissues related to Mixed Lacrimal Gland Cancer:

41
Bone, Eye, Colon, Bone Marrow

Publications for Mixed Lacrimal Gland Cancer

Articles related to Mixed Lacrimal Gland Cancer:

# Title Authors Year
1
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
2
The interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the lacrimal gland. ( 27286739 )
2016
3
Mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland: a rare presentation. ( 25005213 )
2014
4
Comprehensive management of a rare carcinoma ex pleomorphic adenoma of the lacrimal gland with a modified lateral orbitotomy access osteotomy. A case report. ( 21445559 )
2012
5
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 18369704 )
2008
6
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. ( 17881995 )
2007
7
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 17416946 )
2006

Variations for Mixed Lacrimal Gland Cancer

Expression for Mixed Lacrimal Gland Cancer

Search GEO for disease gene expression data for Mixed Lacrimal Gland Cancer.

Pathways for Mixed Lacrimal Gland Cancer

Pathways related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 IL6 JAK1 STAT3 TYK2
2
Show member pathways
13.08 IL6 JAK1 STAT3 TYK2
3
Show member pathways
12.82 IL6 JAK1 STAT3 TYK2
4
Show member pathways
12.81 IL6 JAK1 STAT3 TYK2
5
Show member pathways
12.74 IL6 JAK1 TYK2
6
Show member pathways
12.73 IL6 JAK1 TYK2
7
Show member pathways
12.62 IL6 JAK1 STAT3
8 12.6 IL6 JAK1 STAT3
9
Show member pathways
12.6 IL6 JAK1 STAT3 TYK2
10
Show member pathways
12.58 IL6 JAK1 STAT3 TYK2
11
Show member pathways
12.55 IL6 JAK1 STAT3
12
Show member pathways
12.43 IL6 JAK1 STAT3 TYK2
13
Show member pathways
12.41 IL6 JAK1 STAT3 TYK2
14 12.37 JAK1 STAT3 TYK2
15
Show member pathways
12.22 JAK1 STAT3 TYK2
16
Show member pathways
12.21 IL6 JAK1 STAT3 TYK2
17
Show member pathways
12.17 JAK1 STAT3 TYK2
18
Show member pathways
12.16 IL6 JAK1 STAT3
19
Show member pathways
12.09 JAK1 STAT3 TYK2
20
Show member pathways
12.09 JAK1 STAT3 TYK2
21
Show member pathways
12.09 IL6 JAK1 STAT3 TYK2
22
Show member pathways
12.07 IL6 JAK1 TYK2
23
Show member pathways
12.06 JAK1 STAT3 TYK2
24 12.06 IL6 JAK1 STAT3 TYK2
25 12.03 IL6 JAK1 STAT3
26
Show member pathways
11.96 IL6 JAK1
27 11.95 JAK1 STAT3
28
Show member pathways
11.94 JAK1 STAT3
29 11.92 JAK1 STAT3 TYK2
30
Show member pathways
11.91 JAK1 STAT3
31
Show member pathways
11.9 IL6 STAT3
32 11.88 JAK1 STAT3
33
Show member pathways
11.87 IL6 STAT3
34
Show member pathways
11.87 IL6 JAK1 STAT3
35
Show member pathways
11.86 JAK1 STAT3
36 11.85 IL6 STAT3
37 11.85 IL6 STAT3
38 11.83 JAK1 TYK2
39
Show member pathways
11.82 IL6 JAK1 STAT3 TYK2
40
Show member pathways
11.77 STAT3 TYK2
41
Show member pathways
11.76 IL6 STAT3
42
Show member pathways
11.76 IL6 JAK1 STAT3
43 11.72 IL6 STAT3
44 11.71 IL6 STAT3
45 11.68 IL6 JAK1 STAT3 TYK2
46 11.61 IL6 JAK1 STAT3 TYK2
47 11.54 JAK1 STAT3
48 11.51 JAK1 STAT3 TYK2
49
Show member pathways
11.49 IL6 JAK1 STAT3 TYK2
50 11.47 IL6 JAK1 STAT3

GO Terms for Mixed Lacrimal Gland Cancer

Biological processes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.72 JAK1 STAT3 TYK2
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL6 STAT3
3 type I interferon signaling pathway GO:0060337 9.52 JAK1 TYK2
4 interleukin-12-mediated signaling pathway GO:0035722 9.51 JAK1 TYK2
5 acute-phase response GO:0006953 9.49 IL6 STAT3
6 interleukin-7-mediated signaling pathway GO:0038111 9.48 JAK1 STAT3
7 interleukin-15-mediated signaling pathway GO:0035723 9.46 JAK1 STAT3
8 cytokine-mediated signaling pathway GO:0019221 9.46 IL6 JAK1 STAT3 TYK2
9 interleukin-35-mediated signaling pathway GO:0070757 9.43 JAK1 STAT3
10 interleukin-23-mediated signaling pathway GO:0038155 9.4 STAT3 TYK2
11 interleukin-9-mediated signaling pathway GO:0038113 9.37 JAK1 STAT3
12 interleukin-21-mediated signaling pathway GO:0038114 9.32 JAK1 STAT3
13 T-helper 17 cell lineage commitment GO:0072540 9.26 IL6 STAT3
14 interleukin-6-mediated signaling pathway GO:0070102 9.13 IL6 JAK1 STAT3
15 interleukin-27-mediated signaling pathway GO:0070106 8.8 JAK1 STAT3 TYK2

Molecular functions related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.32 JAK1 TYK2
2 protein phosphatase binding GO:0019903 9.26 JAK1 STAT3
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.16 JAK1 TYK2
4 growth hormone receptor binding GO:0005131 8.96 JAK1 TYK2
5 CCR5 chemokine receptor binding GO:0031730 8.62 JAK1 STAT3

Sources for Mixed Lacrimal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....