MCID: MXD006
MIFTS: 28

Mixed Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Mixed Liposarcoma

MalaCards integrated aliases for Mixed Liposarcoma:

Name: Mixed Liposarcoma 12 15 70
Mixed-Type Liposarcoma 12 15
Myxoid/round Cell Liposarcoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5703 DOID:5709
NCIt 50 C27781 C4253
SNOMED-CT 67 11073003
UMLS 70 C0334472 C0545074

Summaries for Mixed Liposarcoma

MalaCards based summary : Mixed Liposarcoma, also known as mixed-type liposarcoma, is related to fibrous histiocytoma and malignant fibrous histiocytoma. An important gene associated with Mixed Liposarcoma is FUS (FUS RNA Binding Protein), and among its related pathways/superpathways are Bladder cancer and Transcriptional misregulation in cancer. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Mixed Liposarcoma

Diseases related to Mixed Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 fibrous histiocytoma 30.1 FUS CD34
2 malignant fibrous histiocytoma 29.4 MDM2 DDIT3 CDK4
3 cellular myxoid liposarcoma 29.4 MDM2 FUS DDIT3 CDK4
4 pleomorphic lipoma 29.3 MDM2 LHFPL6 CDK4 CD34
5 well-differentiated liposarcoma 29.2 MDM2 FUS DDIT3 CDK4 CD34
6 myxoid liposarcoma 29.0 MDM2 FUS DDIT3 CDK4
7 pleomorphic liposarcoma 29.0 MDM2 FUS DDIT3 CDK4
8 liposarcoma 28.8 MDM2 FUS DDIT3 CDK4 CD34
9 lipomatosis, multiple 28.3 MDM2 LHFPL6 FUS DDIT3 CDK4 CD34
10 retroperitoneal liposarcoma 10.2
11 ring chromosome 7 10.1 MDM2 CDK4
12 ring chromosome 10.1 MDM2 CDK4
13 mediastinum liposarcoma 10.1 MDM2 CDK4
14 undifferentiated embryonal sarcoma of the liver 10.1 MDM2 CDK4
15 embryonal sarcoma 10.1 MDM2 CDK4
16 diffuse lipomatosis 10.1 MDM2 CDK4
17 lipoblastoma 10.1 MDM2 CDK4
18 malignant inflammatory fibrous histiocytoma 10.1 MDM2 CDK4
19 angiolipoma 10.1 MDM2 CD34
20 paratesticular lipoma 10.1 MDM2 CDK4
21 lipoma of spermatic cord 10.1 MDM2 CDK4
22 adult liposarcoma 10.1 MDM2 CDK4
23 aortic malignant tumor 10.1 MDM2 CD34
24 juxtacortical osteosarcoma 10.1 MDM2 CDK4
25 peripheral osteosarcoma 10.1 MDM2 CDK4
26 rare tumor 10.1
27 parameningeal embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
28 embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
29 inflammatory liposarcoma 10.1 MDM2 CD34
30 hereditary melanoma 10.1 MDM2 CDK4
31 heart sarcoma 10.1 MDM2 CD34
32 myositis ossificans 10.1 MDM2 CDK4
33 familial retinoblastoma 10.0 MDM2 CDK4
34 conventional central osteosarcoma 10.0 MDM2 CDK4
35 malignant mesenchymoma 10.0 MDM2 CD34
36 conventional fibrosarcoma 10.0 MDM2 CD34
37 heart cancer 10.0 MDM2 CD34
38 synovium cancer 10.0 FUS CD34
39 hemangiopericytoma, malignant 10.0 MDM2 CD34
40 spindle cell sarcoma 10.0 MDM2 CD34
41 gastrointestinal stromal tumor 9.9
42 benign breast phyllodes tumor 9.9
43 posttransplant acute limbic encephalitis 9.9
44 rare soft tissue tumor 9.9
45 bone osteosarcoma 9.9 MDM2 CDK4
46 skeletal muscle cancer 9.9 MDM2 CD34
47 sclerosing liposarcoma 9.9 MDM2 FUS CD34
48 gastric liposarcoma 9.9 MDM2 CDK4 CD34
49 sarcoma, synovial 9.9 MDM2 FUS CD34
50 liposarcoma of bone 9.9 MDM2 CDK4 CD34

Graphical network of the top 20 diseases related to Mixed Liposarcoma:



Diseases related to Mixed Liposarcoma

Symptoms & Phenotypes for Mixed Liposarcoma

GenomeRNAi Phenotypes related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CD34 CDK4 DDIT3 MDM2

MGI Mouse Phenotypes related to Mixed Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD34 CDK4 DDIT3 MDM2

Drugs & Therapeutics for Mixed Liposarcoma

Drugs for Mixed Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
4 Gastrointestinal Agents Phase 2
5 Antineoplastic Agents, Hormonal Phase 2
6 Hormones Phase 2
7 glucocorticoids Phase 2
8 Hormone Antagonists Phase 2
9 Antiemetics Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Anti-Infective Agents Early Phase 1
12 Antiviral Agents Early Phase 1
13 interferons Early Phase 1
14 Interferon-gamma Early Phase 1
15 Interferon-alpha Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter Phase II Clinical Trial of Neoadjuvant Trabectedin (Yondelis) in Patients With Localized Myxoid / Round Cell Liposarcoma Completed NCT00579501 Phase 2 Trabectedin;Dexamethasone
2 A Pilot Study of NY-ESO-1ᶜ²⁵⁹T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma Recruiting NCT02992743 Phase 2
3 A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR™ T Cells in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma Recruiting NCT04044768 Phase 2
4 A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma. Completed NCT01477021 Phase 1 cyclophosphamide
5 A Study to Determine the Feasibility of Treating Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Using Autologous NY-ESO-1 Specific CD8+ T Cells With Cyclophosphamide Pre-conditioning But Without the Use of IL-2 Withdrawn NCT02059850 Phase 1 Cyclophosphamide
6 A Pilot Study to Test Whether Systemic Interferon Gamma Increases Tumor Class I MHC Expression in Patients With Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Terminated NCT01957709 Early Phase 1

Search NIH Clinical Center for Mixed Liposarcoma

Genetic Tests for Mixed Liposarcoma

Anatomical Context for Mixed Liposarcoma

MalaCards organs/tissues related to Mixed Liposarcoma:

40
T Cells

Publications for Mixed Liposarcoma

Articles related to Mixed Liposarcoma:

(show all 40)
# Title Authors PMID Year
1
[A Case of Pelvic Liposarcoma Resected by Hybrid Approach]. 61
33468856 2020
2
A rare case of mixed type liposarcoma of breast arising in malignant phyllodes tumor. 61
31493302 2020
3
Giant recurrent mixed-type liposarcoma of the retroperitoneum: report of a case and review of literature. 61
31933956 2019
4
[Mixed Type Liposarcoma with Intra-Abdominal Bleeding - Report of a Case]. 61
29394565 2017
5
Paratesticular dedifferentiated liposarcoma with prominent myxoid stroma: report of a case and review of the literature. 61
25986682 2017
6
[A Case of Primary Liposarcoma Arising from the Duodenum]. 61
28133321 2016
7
Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma. 61
25124571 2014
8
Primary subcutaneous mixed-type liposarcoma of the thigh showing three simultaneous dedifferentiations: report of an unusual case. 61
24441237 2013
9
Surgical experience with retroperitoneal liposarcoma in a single korean tertiary medical center. 61
22670189 2012
10
Giant mixed-type liposarcoma of the mesentery: case report. 61
22920010 2012
11
Primary dedifferentiated liposarcoma of the axilla arising in a mixed, well-differentiated and myxoid liposarcoma. 61
22690275 2012
12
Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis. 61
20473880 2011
13
Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data. 61
20934400 2010
14
[Recurrent primary mediastinal liposarcoma with histological change]. 61
21111281 2010
15
[Retroperitoneal mixed-type liposarcoma detected by health examination]. 61
19827617 2009
16
Primary pulmonary liposarcoma--a case report. 61
19241318 2009
17
Giant retroperitoneal liposarcoma with mixed histological pattern: a rare presentation and literature review. 61
19937402 2009
18
Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. 61
19097538 2008
19
Liposarcoma of the pleural cavity. 61
18810708 2008
20
Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity. 61
18551309 2008
21
[Retroperitoneal giant mixed sarcoma. Case report]. 61
18507961 2008
22
Spermatic cord mixed liposarcoma. Case report and review of the literature. 61
18273513 2008
23
Gene expression in mixed type liposarcoma. 61
16581650 2006
24
[Giant retroperitoneal liposarcoma. One case report]. 61
15710262 2005
25
Giant mixed-type perinephric liposarcoma. 61
15783094 2004
26
Radiologically and histologically mixed liposarcoma: a report of two biphasic cases. 61
14594943 2003
27
Rhabdomyosarcoma arising in a congenital melanocytic nevus. 61
11803277 2002
28
Hibernoma, an uncommon tumor as a differential diagnosis of liposarcoma of the thigh. 61
11205222 2000
29
Case of retroperitoneal dedifferentiated mixed-type liposarcoma: comparison of proliferative activity in specimens from four operations. 61
10477874 1999
30
Mixed-type liposarcoma of the oral cavity: a case with unusual features and a long survival. 61
10069544 1999
31
Primary retroperitoneal liposarcoma mimicking ovarian cancer: a case report. 61
9650434 1998
32
Primary liposarcoma of the mediastinum. 61
18521256 1998
33
Dedifferentiated myxoid liposarcoma: a clinicopathological study suggesting a closer relationship between myxoid and well-differentiated liposarcoma. 61
9181367 1997
34
Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11) 61
7889498 1995
35
[Paratesticular tumor. Liposarcoma of the spermatic cord]. 61
8368109 1993
36
Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3. 61
8453640 1993
37
[Retroperitoneal mixed type liposarcoma: a case report]. 61
2048492 1991
38
Primary liposarcoma of the jejunum. 61
2084641 1990
39
Case report 637. Mixed type liposarcoma with myxoid and pleomorphic patterns. 61
2255956 1990
40
An unusual neoplasm of adipose tissue in a rat. 61
459416 1979

Variations for Mixed Liposarcoma

Expression for Mixed Liposarcoma

Search GEO for disease gene expression data for Mixed Liposarcoma.

Pathways for Mixed Liposarcoma

Pathways related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 MDM2 CDK4
2 11.08 MDM2 FUS DDIT3
3 11.06 DDIT3 CDK4
4 10.92 MDM2 CDK4
5 10.8 MDM2 CDK4
6 10.46 MDM2 CDK4

GO Terms for Mixed Liposarcoma

Biological processes related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 8.96 MDM2 CDK4
2 negative regulation of cell cycle arrest GO:0071157 8.62 MDM2 CDK4

Sources for Mixed Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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