MCID: MXD019
MIFTS: 24

Mixed Malaria

Categories: Infectious diseases

Aliases & Classifications for Mixed Malaria

MalaCards integrated aliases for Mixed Malaria:

Name: Mixed Malaria 12 15 72
Malaria Fever by More Than One Parasite 12
Malaria by More Than One Parasite 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14325
ICD9CM 35 084.5
SNOMED-CT 68 21070001
UMLS 72 C0153121

Summaries for Mixed Malaria

Disease Ontology : 12 A malaria that involves infection with more than one species of Plasmodium at the same time.

MalaCards based summary : Mixed Malaria, also known as malaria fever by more than one parasite, is related to malaria and multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly. An important gene associated with Mixed Malaria is RCAN1 (Regulator Of Calcineurin 1), and among its related pathways/superpathways is Role of Calcineurin-dependent NFAT signaling in lymphocytes. The drugs Amodiaquine and Lumefantrine have been mentioned in the context of this disorder. Affiliated tissues include kidney and testes.

Related Diseases for Mixed Malaria

Diseases related to Mixed Malaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 malaria 28.9 MT-CYB F3 ACKR1
2 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
3 cholecystitis 9.8
4 acalculous cholecystitis 9.8
5 acute pancreatitis 9.8
6 glomerulonephritis 9.8
7 myelitis 9.8
8 pancreatitis 9.8
9 acute disseminated encephalomyelitis 9.8
10 blood platelet disease 9.7 WAS F3
11 thrombocytopenia 9.5 WAS F3
12 parasitic protozoa infectious disease 9.4 MT-CYB ACKR1

Graphical network of the top 20 diseases related to Mixed Malaria:



Diseases related to Mixed Malaria

Symptoms & Phenotypes for Mixed Malaria

Drugs & Therapeutics for Mixed Malaria

Drugs for Mixed Malaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amodiaquine Approved, Investigational 86-42-0 2165
2
Lumefantrine Approved 82186-77-4 6437380
3
Artemether Approved 71963-77-4 68911 119380
4
Artesunate Approved, Investigational 88495-63-0 5464098 6917864
5
Lactitol Investigational 585-86-4, 585-88-6 493591
6 Amodiaquine, artesunate drug combination
7 Anti-Infective Agents
8 Antiparasitic Agents
9 Anthelmintics
10 Antiprotozoal Agents
11 Antimalarials
12 Antiviral Agents
13 Artemether, Lumefantrine Drug Combination

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium Falciparum Malaria in Pweto, Democratic Republic of Congo, 2008 Completed NCT01567423 ASAQ Winthrop® Sanofi Aventis;Coartem®, Novartis

Search NIH Clinical Center for Mixed Malaria

Genetic Tests for Mixed Malaria

Anatomical Context for Mixed Malaria

MalaCards organs/tissues related to Mixed Malaria:

41
Kidney, Testes

Publications for Mixed Malaria

Articles related to Mixed Malaria:

(show top 50) (show all 57)
# Title Authors PMID Year
1
Ribosomal and non-ribosomal PCR targets for the detection of low-density and mixed malaria infections. 38
31039781 2019
2
Donor-derived multiorgan transmission of mixed P. malariae and P. ovale infection: Impact of globalization on post-transplant infections. 38
29863799 2018
3
Imported Malaria in Turkey: The Importance of Diagnosis and Treatment of Plasmodium falciparum/Plasmodium vivax Mixed Infection. 38
29780010 2018
4
Mortality in Malaria: Intensive Care (MIMIC). 38
30347945 2018
5
Successful management of necrotizing pancreatitis in mixed malaria and review of literature. 38
29930900 2018
6
Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection. 38
30300411 2018
7
Prevalence of malaria in two highly endemic Community Health Centers in the Bastar district, Chhattisgarh showing mixed infections with Plasmodium species. 38
29203789 2017
8
Documentation of Malaria Parasite ( Plasmodium spp.) Infection and Associated Mortality in a Common Loon (Gavia immer). 38
28665230 2017
9
Severe vivax malaria: a prospective exploration at a tertiary healthcare centre in Southwestern India. 38
28367735 2017
10
Complicated malaria in children and adults from three settings of the Colombian Pacific Coast: A prospective study. 38
28945797 2017
11
High burden of malaria and anemia among tribal pregnant women in a chronic conflict corridor in India. 38
28649273 2017
12
Early treatment failure in concurrent dengue and mixed malaria species infection with suspected resistance to artemisinin combination therapy from a tertiary care center in Delhi: a case report. 38
28860870 2017
13
Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. 38
27884146 2016
14
A Clinical Study of Acute Kidney Injury in Tropical Acute Febrile Illness. 38
27656476 2016
15
Clinical and Laboratory Profile of Hospitalized Malarial Patients: An Agra-Based Study. 38
27762108 2016
16
[THE CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF MALARIA CONCURRENT WITH OTHER INFECTIONS AND INVASIONS]. 38
27405219 2016
17
Severe and benign Plasmodium vivax malaria in Emberá (Amerindian) children and adolescents from an endemic municipality in Western Colombia. 38
26454733 2016
18
Malaria Prevalence and Its Associated Risk Factors among Patients Attending Chichu and Wonago Health Centres, South Ethiopia. 38
28087849 2016
19
Patterns of mixed Plasmodium species infections among children six years and under in selected malaria hyper-endemic communities of Zambia: population-based survey observations. 38
25930101 2015
20
Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia. 38
25889074 2015
21
Molecular investigation of mixed malaria infections in southwest Saudi Arabia. 38
25719595 2015
22
Clinical Profile and Prognostic Indicators in Adults Hospitalized with Severe Malaria Caused by Different Plasmodium Species. 38
26692763 2015
23
Haemophagocytic lymphohistiocytosis: a cause of unresponsive malaria in a 5-year-old girl. 38
26744159 2015
24
Haemophagocytic lymphohistiocytosis: a cause of unresponsive malaria in a 5-year-old girl. 38
25410687 2014
25
The outcome of a test-treat package versus routine outpatient care for Ghanaian children with fever: a pragmatic randomized control trial. 38
25428264 2014
26
Thrombocytopenia in malaria: its usefulness in a clinical setting. A study from Western Rajasthan, India. 38
25082339 2014
27
[A case of imported mixed malaria in Kharkov]. 38
25812417 2014
28
Molecular evidence of Plasmodium vivax mono and mixed malaria parasite infections in Duffy-negative native Cameroonians. 38
25084090 2014
29
The study of complications of vivax malaria in comparison with falciparum malaria in Mumbai. 38
23777019 2012
30
Thrombocytopenia in childhood malaria with special reference to P. vivax monoinfection: A study from Bikaner (Northwestern India). 38
21864016 2012
31
Infectious disease case: mixed malaria infection with Plasmodium falciparum and Plasmodium vivax in a deployed service member in Afghanistan. 38
22128640 2011
32
Acid phosphatase as a marker in malaria. 38
23024477 2011
33
Acute disseminated encephalomyelitis after mixed malaria infection (Plasmodium falciparum and Plasmodium vivax) with MRI closely simulating multiple sclerosis. 38
21881471 2011
34
Comparison of the Clinical Profile and Complications of Mixed Malarial Infections of Plasmodium Falciparum and Plasmodium Vivax versus Plasmodium Falciparum Mono-infection. 38
22087380 2011
35
A review of mixed malaria species infections in anopheline mosquitoes. 38
21880138 2011
36
[Urgent tasks of malaria elimination programs]. 38
21936086 2011
37
Acute kidney injury in tropical acute febrile illness in a tertiary care centre--RIFLE criteria validation. 38
20702532 2011
38
Acute acalculous cholecystitis complicating an imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium vivax. 38
19932042 2010
39
Immune response to Plasmodium vivax has a potential to reduce malaria severity. 38
20030672 2010
40
Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination. 38
20409349 2010
41
A mixed malaria infection: is Plasmodium vivax good for you? 38
19740502 2010
42
Evaluation of three PCR-based diagnostic assays for detecting mixed Plasmodium infection. 38
20356398 2010
43
Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India). 38
21050055 2010
44
Symmetric peripheral gangrene with mixed malaria. 38
17595506 2007
45
Within-host competition in genetically diverse malaria infections: parasite virulence and competitive success. 38
16929653 2006
46
[An imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium ovale.]. 38
17160826 2005
47
Western blot diagnosis of vivax malaria with multiple stage-specific antigens of the parasite. 38
11441504 2001
48
[Practicability of IFAT using Plasmodium cynomolgi and Plasmodium falciparum antigens in different malarious areas]. 38
12567477 2000
49
Mixed malaria infection. 38
10071374 1999
50
Transmission of mixed malaria species and strains by mosquitoes, as detected by PCR, in a study area in Guinea-Bissau. 38
9419850 1997

Variations for Mixed Malaria

Expression for Mixed Malaria

Search GEO for disease gene expression data for Mixed Malaria.

Pathways for Mixed Malaria

Pathways related to Mixed Malaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.33 XPO1 RCAN1

GO Terms for Mixed Malaria

Biological processes related to Mixed Malaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 8.62 WAS ACKR1

Sources for Mixed Malaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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