MCID: MXD012
MIFTS: 32

Mixed Oligodendroglioma-Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Mixed Oligodendroglioma-Astrocytoma

MalaCards integrated aliases for Mixed Oligodendroglioma-Astrocytoma:

Name: Mixed Oligodendroglioma-Astrocytoma 12 15 71
Who Grade Ii Mixed Glioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7912
MeSH 43 D009837
NCIt 49 C4050
UMLS 71 C0280793

Summaries for Mixed Oligodendroglioma-Astrocytoma

MalaCards based summary : Mixed Oligodendroglioma-Astrocytoma, also known as who grade ii mixed glioma, is related to oligoastrocytoma and anaplastic oligodendroglioma, and has symptoms including seizures and headache. An important gene associated with Mixed Oligodendroglioma-Astrocytoma is ATRX (ATRX Chromatin Remodeler), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone and brain, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Mixed Oligodendroglioma-Astrocytoma

Diseases related to Mixed Oligodendroglioma-Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 oligoastrocytoma 33.2 MGMT IDH2
2 anaplastic oligodendroglioma 31.0 MGMT IDH2
3 oligodendroglioma 29.0 TP53 TERT PTEN MGMT IDH2 IDH1
4 enchondroma 10.5 IDH2 IDH1
5 breast intraductal papillomatosis 10.5 IDH2 IDH1
6 cecal benign neoplasm 10.5 TERT PTEN
7 cecum adenoma 10.5 TERT PTEN
8 primary cutaneous t-cell lymphoma 10.4 TERT PDCD1
9 breast papillomatosis 10.4 IDH2 IDH1
10 glial tumor 10.4 PTEN IDH1
11 cytogenetically normal acute myeloid leukemia 10.4 IDH2 IDH1
12 intracranial chondrosarcoma 10.4 IDH2 IDH1
13 spinal cord astrocytoma 10.4 MGMT IDH1
14 laryngeal neuroendocrine tumor 10.4 TP53 IDH1
15 periosteal chondrosarcoma 10.4 IDH2 IDH1
16 adult oligodendroglioma 10.3 IDH2 IDH1
17 juxtacortical chondroma 10.3 IDH2 IDH1
18 urinary tract papillary transitional cell benign neoplasm 10.3 TP53 TERT
19 adult brain stem glioma 10.3 MGMT IDH2 IDH1
20 bladder papillary transitional cell neoplasm 10.3 TP53 TERT
21 frontal lobe neoplasm 10.3 TP53 MGMT IDH1
22 lung benign neoplasm 10.3 TP53 TERT MGMT
23 multiple enchondromatosis, maffucci type 10.3 IDH2 IDH1 ATRX
24 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1 ATRX
25 malignant ependymoma 10.3 TP53 MGMT IDH1
26 thyroid gland follicular carcinoma 10.3 TP53 TERT PTEN
27 breast duct papilloma 10.3 PTEN IDH2 IDH1
28 supratentorial cancer 10.3 TP53 MGMT IDH1
29 breast hemangioma 10.3 TP53 IDH2 IDH1
30 thyroid tumor 10.3 TP53 TERT PTEN
31 acral lentiginous melanoma 10.3 TERT PTEN CD274
32 chondroblastic osteosarcoma 10.3 TP53 IDH2 IDH1
33 cheilitis 10.3 TP53 PDCD1 CD274
34 pilomyxoid astrocytoma 10.3 IDH2 IDH1 ATRX
35 high-grade astrocytoma 10.3 PTEN IDH1
36 juvenile pilocytic astrocytoma 10.3 PTEN MGMT IDH1
37 central nervous system lymphoma 10.3 TP53 MGMT CD274
38 ovarian clear cell carcinoma 10.3 TP53 TERT PTEN
39 thoracic benign neoplasm 10.3 TP53 IDH2 IDH1
40 breast benign neoplasm 10.3 TP53 IDH2 IDH1
41 differentiated thyroid carcinoma 10.3 TP53 TERT CD274
42 skin squamous cell carcinoma 10.3 TP53 PTEN MGMT
43 gliomatosis cerebri 10.3 TP53 PTEN IDH1
44 thymus gland disease 10.3 TP53 PTEN CD274
45 uterine corpus endometrial carcinoma 10.2 TP53 PTEN IDH1
46 thymus cancer 10.2 TP53 PTEN CD274
47 angioimmunoblastic t-cell lymphoma 10.2 PDCD1 ITK IDH2
48 interval angle-closure glaucoma 10.2 IDH2 IDH1
49 adenosquamous carcinoma 10.2 TP53 PTEN CD274
50 temporal lobe neoplasm 10.2 TERT MGMT IDH1 ATRX

Graphical network of the top 20 diseases related to Mixed Oligodendroglioma-Astrocytoma:



Diseases related to Mixed Oligodendroglioma-Astrocytoma

Symptoms & Phenotypes for Mixed Oligodendroglioma-Astrocytoma

UMLS symptoms related to Mixed Oligodendroglioma-Astrocytoma:


seizures, headache

GenomeRNAi Phenotypes related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ATRX CALR FAS IDH2 ITK PTEN

MGI Mouse Phenotypes related to Mixed Oligodendroglioma-Astrocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ATRX CALR CD274 CDKN2B DAPK1 FAS
2 homeostasis/metabolism MP:0005376 10.28 CALR CD274 CD276 CDKN2B CFH DAPK1
3 hematopoietic system MP:0005397 10.25 CD274 CD276 CDKN2B CFH FAS IDH1
4 immune system MP:0005387 10.21 CCL22 CD274 CD276 CDKN2B CFH FAS
5 mortality/aging MP:0010768 10.2 ATRX CALR CCL22 CD274 CDKN2B CFH
6 endocrine/exocrine gland MP:0005379 10.11 CDKN2B FAS ITK MGMT PDCD1 PTEN
7 neoplasm MP:0002006 9.86 CDKN2B FAS IDH2 MGMT PDCD1 PTEN
8 renal/urinary system MP:0005367 9.76 CDKN2B CFH DAPK1 FAS PDCD1 PTEN
9 respiratory system MP:0005388 9.56 FAS IDH1 MGMT PDCD1 PTEN TERT
10 skeleton MP:0005390 9.32 CD274 CD276 FAS IDH1 IDH2 PDCD1

Drugs & Therapeutics for Mixed Oligodendroglioma-Astrocytoma

Search Clinical Trials , NIH Clinical Center for Mixed Oligodendroglioma-Astrocytoma

Genetic Tests for Mixed Oligodendroglioma-Astrocytoma

Anatomical Context for Mixed Oligodendroglioma-Astrocytoma

MalaCards organs/tissues related to Mixed Oligodendroglioma-Astrocytoma:

40
Bone, Brain

Publications for Mixed Oligodendroglioma-Astrocytoma

Articles related to Mixed Oligodendroglioma-Astrocytoma:

# Title Authors PMID Year
1
Immunosignaturing can detect products from molecular markers in brain cancer. 61
22815729 2012
2
Haemorrhagic presentation of low-grade glioma in adults. 61
17676407 2007
3
Pediatric oligodendrogliomas. 61
9705589 1998
4
Accuracy of grading gliomas on CT-guided stereotactic biopsies: a survival analysis. 61
9407209 1997
5
Expression of the tumor suppressor gene DCC in human gliomas. 61
8242611 1993
6
The treatment of anaplastic oligodendrogliomas and mixed gliomas. 61
8455760 1993
7
The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. 61
1564535 1992
8
Significance of hemorrhage into brain tumors: clinicopathological study. 61
3316531 1987
9
Metastatic malignant glioma with resultant extradural compression of a sacral nerve root. 61
3559663 1987
10
A survey of ethylnitrosourea-induced rat gliomas for the presence of tumour rejection antigens expressed in vivo. 61
7231638 1981

Variations for Mixed Oligodendroglioma-Astrocytoma

Expression for Mixed Oligodendroglioma-Astrocytoma

Search GEO for disease gene expression data for Mixed Oligodendroglioma-Astrocytoma.

Pathways for Mixed Oligodendroglioma-Astrocytoma

Pathways related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 TP53 TNFRSF9 TNFRSF4 PTEN PDCD1 ITK
2
Show member pathways
13.19 TP53 TNFRSF9 TNFRSF4 PTEN ITK FAS
3 12.52 TP53 TERT PTEN FAS DAPK1 CDKN2B
4 12 TP53 TERT PTEN CDKN2B CALR
5
Show member pathways
11.97 TNFRSF9 PTEN PDCD1 ITK FAS CD274
6 11.77 TP53 PTEN MGMT
7
Show member pathways
11.75 PDCD1 ITK CD274
8 11.68 TNFRSF9 TNFRSF4 PDCD1 ITK FAS CD276
9 11.65 TP53 PTEN CDKN2B
10
Show member pathways
11.57 TNFRSF9 TNFRSF4 FAS
11 11.43 TP53 PTEN ATRX
12 11.3 TP53 PTEN IDH2 IDH1
13 11.24 TP53 PTEN CDKN2B
14 11.04 PTEN PDCD1 ITK
15
Show member pathways
10.64 IDH2 IDH1

GO Terms for Mixed Oligodendroglioma-Astrocytoma

Cellular components related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 9.26 TP53 TERT PTEN ATRX
2 external side of plasma membrane GO:0009897 9.17 TNFRSF9 TNFRSF4 PDCD1 FAS CD276 CD274

Biological processes related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.8 TP53 PTEN MGMT CALR
2 apoptotic process GO:0006915 9.8 TP53 TNFRSF9 PTEN PDCD1 FAS DAPK1
3 regulation of apoptotic process GO:0042981 9.76 TP53 FAS DAPK1 CALR
4 positive regulation of apoptotic process GO:0043065 9.65 TP53 PTEN PDCD1 FAS DAPK1
5 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.52 TP53 ATRX
6 2-oxoglutarate metabolic process GO:0006103 9.51 IDH2 IDH1
7 replicative senescence GO:0090399 9.48 TP53 TERT
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 TP53 TNFRSF9 TNFRSF4 FAS
9 negative regulation of glial cell proliferation GO:0060253 9.43 TERT IDH2
10 NADP metabolic process GO:0006739 9.4 IDH2 IDH1
11 isocitrate metabolic process GO:0006102 9.37 IDH2 IDH1
12 negative regulation of apoptotic process GO:0043066 9.17 TP53 TERT PTEN PDCD1 MGMT FAS
13 glyoxylate cycle GO:0006097 8.96 IDH2 IDH1

Molecular functions related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 TP53 TERT PTEN IDH1 FAS DAPK1
2 chaperone binding GO:0051087 9.5 TP53 TERT CALR
3 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF4 FAS
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Mixed Oligodendroglioma-Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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