MCID: MXD012
MIFTS: 30

Mixed Oligodendroglioma-Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Mixed Oligodendroglioma-Astrocytoma

MalaCards integrated aliases for Mixed Oligodendroglioma-Astrocytoma:

Name: Mixed Oligodendroglioma-Astrocytoma 12 15 71
Who Grade Ii Mixed Glioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7912
MeSH 43 D009837
SNOMED-CT 67 22217002
UMLS 71 C0280793

Summaries for Mixed Oligodendroglioma-Astrocytoma

MalaCards based summary : Mixed Oligodendroglioma-Astrocytoma, also known as who grade ii mixed glioma, is related to oligodendroglioma and oligoastrocytoma, and has symptoms including seizures and headache. An important gene associated with Mixed Oligodendroglioma-Astrocytoma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include brain, bone and t cells, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Mixed Oligodendroglioma-Astrocytoma

Diseases related to Mixed Oligodendroglioma-Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 30.3 PTEN MGMT DAPK1
2 oligoastrocytoma 11.6
3 testicular lymphoma 10.3 PDCD1 CD274
4 autoimmune cardiomyopathy 10.3 PDCD1 CD274
5 gemistocytic astrocytoma 10.3 PTEN MGMT
6 lymphoepithelioma-like carcinoma 10.2 PDCD1 CD274
7 mixed glioma 10.2 PTEN MGMT
8 myopathy, distal, 1 10.2 PDCD1 CD274
9 astrocytoma 10.2
10 anaplastic oligodendroglioma 10.2
11 peripartum cardiomyopathy 10.2 PDCD1 CD274
12 fibrillary astrocytoma 10.1 PTEN MGMT
13 lymphoproliferative syndrome 2 10.1 TNFRSF4 ITK
14 cheilitis 10.0 PDCD1 CD274
15 diabetes mellitus, insulin-dependent, 21 10.0 PDCD1 CD276 CD274
16 epstein-barr virus-associated gastric carcinoma 9.9 FAS CD274
17 diffuse large b-cell lymphoma 9.8 PTEN PDCD1 CD274
18 peripheral t-cell lymphoma 9.8 PTEN PDCD1 ITK CD274
19 stevens-johnson syndrome/toxic epidermal necrolysis 9.8 FAS CCL22
20 squamous cell carcinoma, head and neck 9.7 PTEN PDCD1 MGMT CD274
21 gallbladder cancer 9.7 PTEN MGMT CD274
22 clear cell renal cell carcinoma 9.7 PTEN PDCD1 CD276 CD274
23 lymphadenitis 9.6 PDCD1 FAS CCL22
24 adult t-cell leukemia 9.6 FAS CD274 CCL22
25 viral infectious disease 9.6 PDCD1 FAS CD274
26 brain glioma 9.6 MGMT FAS CD276
27 lymphopenia 9.6 ITK FAS CCL22
28 b-cell lymphoma 9.5 MGMT FAS DAPK1 CD274
29 nodular goiter 9.4 TNFRSF9 TNFRSF4 FAS
30 lymphoma 9.3 PDCD1 MGMT ITK FAS CD274
31 myeloma, multiple 9.2 TNFRSF9 PTEN FAS CD274
32 lung cancer susceptibility 3 9.2 PTEN MGMT FAS DAPK1 CD274
33 cervical cancer 9.2 PTEN MGMT FAS DAPK1 CD274
34 autoimmune disease 9.0 TNFRSF4 PDCD1 FAS CALR
35 leukemia, chronic lymphocytic 9.0 TNFRSF9 PTEN FAS CD274
36 gastric adenocarcinoma 9.0 PTEN PDCD1 MGMT FAS DAPK1 CD274
37 esophageal cancer 9.0 PTEN PDCD1 MGMT FAS DAPK1 CD274
38 cone-rod dystrophy 2 8.9 TNFRSF9 TNFRSF4 FAS CD276
39 glioblastoma multiforme 8.9 PTEN MGMT FAS CD274
40 leukemia, acute myeloid 8.8 TNFRSF9 PTEN FAS CD274 CALR
41 myelodysplastic syndrome 8.7 PTEN PDCD1 MGMT FAS DAPK1 CALR
42 thrombocytopenia 8.5 PTEN PDCD1 MGMT ITK FAS CD274
43 systemic lupus erythematosus 8.5 TNFRSF4 PDCD1 FAS CD276 CD274 CALR

Graphical network of the top 20 diseases related to Mixed Oligodendroglioma-Astrocytoma:



Diseases related to Mixed Oligodendroglioma-Astrocytoma

Symptoms & Phenotypes for Mixed Oligodendroglioma-Astrocytoma

UMLS symptoms related to Mixed Oligodendroglioma-Astrocytoma:


seizures, headache

GenomeRNAi Phenotypes related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.43 CALR FAS ITK PTEN TNFRSF4 TNFRSF9
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 FAS PDCD1 PTEN TNFRSF9
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 DAPK1 FAS PDCD1 PTEN TNFRSF9

MGI Mouse Phenotypes related to Mixed Oligodendroglioma-Astrocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CALR CD274 DAPK1 FAS ITK PDCD1
2 hematopoietic system MP:0005397 9.86 CD274 CD276 FAS ITK PDCD1 PTEN
3 homeostasis/metabolism MP:0005376 9.85 CALR CD274 CD276 DAPK1 FAS MGMT
4 immune system MP:0005387 9.61 CCL22 CD274 CD276 FAS ITK PDCD1
5 mortality/aging MP:0010768 9.28 CALR CCL22 CD274 FAS MGMT PDCD1

Drugs & Therapeutics for Mixed Oligodendroglioma-Astrocytoma

Search Clinical Trials , NIH Clinical Center for Mixed Oligodendroglioma-Astrocytoma

Genetic Tests for Mixed Oligodendroglioma-Astrocytoma

Anatomical Context for Mixed Oligodendroglioma-Astrocytoma

MalaCards organs/tissues related to Mixed Oligodendroglioma-Astrocytoma:

40
Brain, Bone, T Cells, B Cells, Lung, Myeloid

Publications for Mixed Oligodendroglioma-Astrocytoma

Articles related to Mixed Oligodendroglioma-Astrocytoma:

# Title Authors PMID Year
1
Immunosignaturing can detect products from molecular markers in brain cancer. 61
22815729 2012
2
Haemorrhagic presentation of low-grade glioma in adults. 61
17676407 2007
3
Pediatric oligodendrogliomas. 61
9705589 1998
4
Accuracy of grading gliomas on CT-guided stereotactic biopsies: a survival analysis. 61
9407209 1997
5
Expression of the tumor suppressor gene DCC in human gliomas. 61
8242611 1993
6
The treatment of anaplastic oligodendrogliomas and mixed gliomas. 61
8455760 1993
7
The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. 61
1564535 1992
8
Significance of hemorrhage into brain tumors: clinicopathological study. 61
3316531 1987
9
Metastatic malignant glioma with resultant extradural compression of a sacral nerve root. 61
3559663 1987
10
A survey of ethylnitrosourea-induced rat gliomas for the presence of tumour rejection antigens expressed in vivo. 61
7231638 1981

Variations for Mixed Oligodendroglioma-Astrocytoma

Expression for Mixed Oligodendroglioma-Astrocytoma

Search GEO for disease gene expression data for Mixed Oligodendroglioma-Astrocytoma.

Pathways for Mixed Oligodendroglioma-Astrocytoma

Pathways related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 TNFRSF9 TNFRSF4 PTEN PDCD1 ITK CD274
2
Show member pathways
12.99 TNFRSF9 TNFRSF4 PTEN ITK FAS CCL22
3
Show member pathways
12.96 TNFRSF9 TNFRSF4 PTEN FAS CCL22
4
Show member pathways
12.53 ITK FAS CCL22 CALR
5
Show member pathways
11.97 TNFRSF9 PTEN PDCD1 ITK FAS CD274
6 11.75 PDCD1 CD276 CD274
7 11.68 TNFRSF9 TNFRSF4 PDCD1 ITK FAS CD276
8
Show member pathways
11.54 PDCD1 ITK CD274
9 11.22 TNFRSF9 PDCD1 CD276 CD274
10 11.12 PTEN ITK
11 10.93 TNFRSF9 TNFRSF4
12 10.92 PTEN PDCD1 ITK

GO Terms for Mixed Oligodendroglioma-Astrocytoma

Cellular components related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNFRSF9 TNFRSF4 PDCD1 CD276 CD274 CALR

Biological processes related to Mixed Oligodendroglioma-Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.55 TNFRSF9 PTEN PDCD1 FAS DAPK1
2 negative regulation of apoptotic process GO:0043066 9.35 PTEN PDCD1 MGMT FAS DAPK1
3 positive regulation of apoptotic signaling pathway GO:2001235 9.26 PTEN FAS
4 immune response GO:0006955 9.02 TNFRSF4 FAS CD276 CD274 CCL22

Sources for Mixed Oligodendroglioma-Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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