MCID: MXD052
MIFTS: 19

Mixed Phenotype Acute Leukemia with T

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Mixed Phenotype Acute Leukemia with T

MalaCards integrated aliases for Mixed Phenotype Acute Leukemia with T:

Name: Mixed Phenotype Acute Leukemia with T 58
Mpal with T ; Kmt2a Rearranged 58
Mpal with T ; Mll Rearranged 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Orphanet 58 ORPHA589595

Summaries for Mixed Phenotype Acute Leukemia with T

MalaCards based summary : Mixed Phenotype Acute Leukemia with T, also known as mpal with t ; kmt2a rearranged, is related to acute leukemia and mixed phenotype acute leukemia. An important gene associated with Mixed Phenotype Acute Leukemia with T is WT1 (WT1 Transcription Factor), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include myeloid.

Related Diseases for Mixed Phenotype Acute Leukemia with T

Graphical network of the top 20 diseases related to Mixed Phenotype Acute Leukemia with T:



Diseases related to Mixed Phenotype Acute Leukemia with T

Symptoms & Phenotypes for Mixed Phenotype Acute Leukemia with T

Drugs & Therapeutics for Mixed Phenotype Acute Leukemia with T

Search Clinical Trials , NIH Clinical Center for Mixed Phenotype Acute Leukemia with T

Genetic Tests for Mixed Phenotype Acute Leukemia with T

Anatomical Context for Mixed Phenotype Acute Leukemia with T

MalaCards organs/tissues related to Mixed Phenotype Acute Leukemia with T:

40
Myeloid

Publications for Mixed Phenotype Acute Leukemia with T

Articles related to Mixed Phenotype Acute Leukemia with T:

(show all 13)
# Title Authors PMID Year
1
[Clinical Characteristics of Patients with Ph+ Mixed Phenotype Acute Leukemia]. 61
30998137 2019
2
Xiao W, Bharadwaj M, Levine M, et al. PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. Blood Adv. 2018;2(23):3526-3539. 61
30926597 2019
3
Mixed-phenotype acute leukemia with t(4;11)(q21;q23) KMT2A-AFF1-rearranged. 61
30872272 2019
4
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. 61
30530780 2018
5
Mixed phenotype acute leukemia with t(9;22): success with nonacute myeloid leukemia-type intensive induction therapy and stem cell transplantation. 61
28396764 2017
6
First Case of Biphenotypic/bilineal (B/myeloid, B/monocytic) Mixed Phenotype Acute Leukemia with t(9;22)(q34;q11.2);BCR-ABL1. 61
27466307 2016
7
A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33). 61
28105379 2016
8
Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities. 61
27607436 2016
9
Four cases of chronic myelogenous leukemia in mixed phenotype blast phase at initial presentation mimicking mixed phenotype acute leukemia with t(9;22). 61
24422198 2014
10
[Detection of BCR-ABL1 chimeric gene-positive neutrophils in a patient with mixed phenotype acute leukemia]. 61
24305542 2013
11
Therapy-related, mixed phenotype acute leukemia with t(1;21)(p36;q22) and RUNX1 rearrangement. 61
20682397 2010
12
PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms. 61
20660931 2010
13
Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report. 61
20513125 2010

Variations for Mixed Phenotype Acute Leukemia with T

Expression for Mixed Phenotype Acute Leukemia with T

Search GEO for disease gene expression data for Mixed Phenotype Acute Leukemia with T.

Pathways for Mixed Phenotype Acute Leukemia with T

Pathways related to Mixed Phenotype Acute Leukemia with T according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 WT1 RUNX1
2 10.75 WT1 RUNX1

GO Terms for Mixed Phenotype Acute Leukemia with T

Cellular components related to Mixed Phenotype Acute Leukemia with T according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.26 WT1 RUNX1 PHF6 DNMT3A
2 chromosome, centromeric region GO:0000775 8.62 PHF6 DNMT3A

Biological processes related to Mixed Phenotype Acute Leukemia with T according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron differentiation GO:0030182 8.96 RUNX1 DNMT3A
2 negative regulation of transcription by RNA polymerase II GO:0000122 8.92 WT1 RUNX1 PHF6 DNMT3A

Molecular functions related to Mixed Phenotype Acute Leukemia with T according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.16 WT1 RUNX1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.13 WT1 RUNX1 DNMT3A
3 DNA binding GO:0003677 8.92 WT1 RUNX1 PHF6 DNMT3A

Sources for Mixed Phenotype Acute Leukemia with T

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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