MCID: MXD044
MIFTS: 25

Mixed Sleep Apnea

Categories: Mental diseases

Aliases & Classifications for Mixed Sleep Apnea

MalaCards integrated aliases for Mixed Sleep Apnea:

Name: Mixed Sleep Apnea 12 15
Sleep Apnea, Mixed Central and Obstructive 74
Complex Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080302
MeSH 45 D012891
UMLS 74 C0338495

Summaries for Mixed Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a combination of central and obstructive sleep apnea.

MalaCards based summary : Mixed Sleep Apnea, also known as sleep apnea, mixed central and obstructive, is related to central sleep apnea and apnea, obstructive sleep. An important gene associated with Mixed Sleep Apnea is SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase). The drugs Calamus and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Mixed Sleep Apnea

Diseases related to Mixed Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 central sleep apnea 29.9 CA1 SRC
2 apnea, obstructive sleep 29.3 AHI1 MMD
3 sleep apnea 10.3
4 cystic fibrosis 9.9
5 speech disorder 9.9
6 rere-related disorders 9.9
7 obesity-hypoventilation syndrome 9.9
8 congestive heart failure 9.9
9 epilepsy 9.9
10 chiari malformation 9.9
11 cleft mitral valve 9.9

Graphical network of the top 20 diseases related to Mixed Sleep Apnea:



Diseases related to Mixed Sleep Apnea

Symptoms & Phenotypes for Mixed Sleep Apnea

GenomeRNAi Phenotypes related to Mixed Sleep Apnea according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.02 FXN
2 Decreased viability GR00301-A 9.02 FXN SRC
3 Decreased viability GR00402-S-2 9.02 FXN SRC

Drugs & Therapeutics for Mixed Sleep Apnea

Drugs for Mixed Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calamus Phase 2
2
Acetylcysteine Approved, Investigational 616-91-1 12035
3
Dextromethorphan Approved 125-71-3 5362449 5360696
4
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
5
Quinidine Approved, Investigational 56-54-2 441074
6
Memantine Approved, Investigational 19982-08-2 4054
7
Cocaine Approved, Illicit Not Applicable 50-36-2 446220 5760
8
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
9
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
10
Cobalamin Experimental 13408-78-1 6857388
11 Vitamin B12
12 Quinidine gluconate
13 Cholinesterase Inhibitors
14 Calciferol
15 N-monoacetylcystine
16 Vitamin B 12
17 Vitamins

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Not yet recruiting NCT03890939 Phase 4
2 Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients Completed NCT00804349 Phase 4
3 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
4 Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea Recruiting NCT03189173 Phase 2 Oxygen
5 Complex Sleep Apnea Syndrome (CompSAS) Resolution Study Completed NCT00915499 Not Applicable
6 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244 Not Applicable
7 Long-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAP Recruiting NCT03043716
8 A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV. Recruiting NCT03421704
9 European Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation Recruiting NCT03032029
10 Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device Completed NCT00720213 Not Applicable
11 Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders Completed NCT01626989 Not Applicable
12 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042 Not Applicable
13 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
14 Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed NCT01175031 Not Applicable
15 Adaptive Servo-Ventilation in "Real Life" Conditions : the OTRLASV Study Completed NCT02429986 Not Applicable
16 COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE Completed NCT02860338
17 Sleep Apnea in Asthmatic Children and Teenagers Completed NCT03034447 Not Applicable

Search NIH Clinical Center for Mixed Sleep Apnea

Genetic Tests for Mixed Sleep Apnea

Anatomical Context for Mixed Sleep Apnea

MalaCards organs/tissues related to Mixed Sleep Apnea:

42
Heart, Lung

Publications for Mixed Sleep Apnea

Articles related to Mixed Sleep Apnea:

# Title Authors Year
1
Emergence of Cheyne-Stokes Breathing After Hypoglossal Nerve Stimulator Implant in a Patient With Mixed Sleep Apnea. ( 30763424 )
2019
2
Implication of mixed sleep apnea events in adult patients with obstructive sleep apnea-hypopnea syndrome. ( 30343435 )
2018
3
Investigating relative respiratory effort signals during mixed sleep apnea using photoplethysmogram. ( 23695488 )
2013
4
Trilevel adaptive servoventilation for the treatment of central and mixed sleep apnea in chronic heart failure patients. ( 23453905 )
2013
5
Severe mixed sleep apnea after bilateral lung transplantation in a cystic fibrosis patient: a case report. ( 21620114 )
2011
6
Preliminary observation of speech disorder in obstructive and mixed sleep apnea. ( 3308347 )
1987
7
A shift from central and mixed sleep apnea to obstructive sleep apnea resulting from low-flow oxygen. ( 4026046 )
1985

Variations for Mixed Sleep Apnea

Expression for Mixed Sleep Apnea

Search GEO for disease gene expression data for Mixed Sleep Apnea.

Pathways for Mixed Sleep Apnea

GO Terms for Mixed Sleep Apnea

Biological processes related to Mixed Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 AHI1 SRC
2 negative regulation of apoptotic process GO:0043066 8.8 AHI1 FXN SRC

Sources for Mixed Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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