MCID: MXD044
MIFTS: 23

Mixed Sleep Apnea

Categories: Mental diseases

Aliases & Classifications for Mixed Sleep Apnea

MalaCards integrated aliases for Mixed Sleep Apnea:

Name: Mixed Sleep Apnea 12 15
Sleep Apnea, Mixed Central and Obstructive 73
Complex Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080302
MeSH 44 D012891
UMLS 73 C0338495

Summaries for Mixed Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a combination of central and obstructive sleep apnea.

MalaCards based summary : Mixed Sleep Apnea, also known as sleep apnea, mixed central and obstructive, is related to central sleep apnea and sleep apnea. An important gene associated with Mixed Sleep Apnea is SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways is C-MYB transcription factor network. The drugs Calamus and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related phenotype is behavior/neurological.

Related Diseases for Mixed Sleep Apnea

Diseases related to Mixed Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 central sleep apnea 30.1 CA1 SRC
2 sleep apnea 10.3
3 apnea, obstructive sleep 10.0 AHI1 MMD
4 cystic fibrosis 9.9
5 speech disorder 9.9
6 phaeohyphomycosis 9.9 LYZ MMD
7 obesity-hypoventilation syndrome 9.9
8 congestive heart failure 9.9
9 epilepsy 9.9
10 chiari malformation 9.9
11 bile duct disease 9.8 ABCB11 TCFL5
12 biliary tract disease 9.7 ABCB11 TCFL5

Graphical network of the top 20 diseases related to Mixed Sleep Apnea:



Diseases related to Mixed Sleep Apnea

Symptoms & Phenotypes for Mixed Sleep Apnea

MGI Mouse Phenotypes related to Mixed Sleep Apnea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 ABCB11 AHI1 FXN LYZ RUNX1T1 SRC

Drugs & Therapeutics for Mixed Sleep Apnea

Drugs for Mixed Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calamus Phase 2
2
Hydroxocobalamin Approved 13422-51-0 11953898 44475014
3
Quinidine Approved, Investigational 56-54-2 441074
4
Memantine Approved, Investigational 19982-08-2 4054
5
Dextromethorphan Approved 125-71-3 5360696 5362449
6
Acetylcysteine Approved, Investigational 616-91-1 12035
7
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
8
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
9
Cobalamin Experimental 13408-78-1 6438156
10 Quinidine gluconate
11 N-monoacetylcystine
12 Calciferol
13 Vitamins
14 Cholinesterase Inhibitors
15 Vitamin B 12
16 Vitamin B12

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea Recruiting NCT03189173 Phase 2 Oxygen
2 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
3 Complex Sleep Apnea Syndrome (CompSAS) Resolution Study Completed NCT00915499 Not Applicable
4 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244 Not Applicable
5 Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders Completed NCT01626989 Not Applicable
6 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042 Not Applicable
7 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
8 Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed NCT01175031 Not Applicable
9 Adaptive Servo-Ventilation in "Real Life" Conditions : the OTRLASV Study Completed NCT02429986 Not Applicable
10 COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE Completed NCT02860338
11 Long-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAP Recruiting NCT03043716
12 A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV. Recruiting NCT03421704
13 European Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation Recruiting NCT03032029

Search NIH Clinical Center for Mixed Sleep Apnea

Genetic Tests for Mixed Sleep Apnea

Anatomical Context for Mixed Sleep Apnea

MalaCards organs/tissues related to Mixed Sleep Apnea:

41
Heart, Lung

Publications for Mixed Sleep Apnea

Articles related to Mixed Sleep Apnea:

# Title Authors Year
1
Implication of mixed sleep apnea events in adult patients with obstructive sleep apnea-hypopnea syndrome. ( 30343435 )
2018
2
Investigating relative respiratory effort signals during mixed sleep apnea using photoplethysmogram. ( 23695488 )
2013
3
Trilevel adaptive servoventilation for the treatment of central and mixed sleep apnea in chronic heart failure patients. ( 23453905 )
2013
4
Severe mixed sleep apnea after bilateral lung transplantation in a cystic fibrosis patient: a case report. ( 21620114 )
2011
5
Preliminary observation of speech disorder in obstructive and mixed sleep apnea. ( 3308347 )
1987
6
A shift from central and mixed sleep apnea to obstructive sleep apnea resulting from low-flow oxygen. ( 4026046 )
1985

Variations for Mixed Sleep Apnea

Expression for Mixed Sleep Apnea

Search GEO for disease gene expression data for Mixed Sleep Apnea.

Pathways for Mixed Sleep Apnea

Pathways related to Mixed Sleep Apnea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 CA1 LYZ

GO Terms for Mixed Sleep Apnea

Biological processes related to Mixed Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 AHI1 SRC
2 cytolysis GO:0019835 8.62 LYZ MMD

Sources for Mixed Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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