MCID: MXD027
MIFTS: 26

Mixed Type Thymoma

Categories: Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Mixed Type Thymoma

MalaCards integrated aliases for Mixed Type Thymoma:

Name: Mixed Type Thymoma 12 15
Thymoma, Mixed Type 12
Thymoma, Type Ab 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3280
NCIt 50 C6885
UMLS 72 C1266092

Summaries for Mixed Type Thymoma

MalaCards based summary : Mixed Type Thymoma, also known as thymoma, mixed type, is related to malignant type ab thymoma and ependymoma. An important gene associated with Mixed Type Thymoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are Neuroscience and B Cell Development Pathways. Affiliated tissues include lung, and related phenotypes are behavior/neurological and integument

Related Diseases for Mixed Type Thymoma

Diseases related to Mixed Type Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 malignant type ab thymoma 11.4
2 ependymoma 10.5 SYP S100B
3 water-clear cell adenoma 10.5 SYP PAX8
4 sensory organ benign neoplasm 10.4 SYP PAX8
5 primary hepatic neuroendocrine carcinoma 10.4 SYP S100B
6 hypoganglionosis 10.4 SYP S100B
7 chordoid meningioma 10.4 SYP S100B
8 rosette-forming glioneuronal tumor 10.4 SYP S100B
9 dysembryoplastic neuroepithelial tumor 10.4 SYP S100B
10 supratentorial primitive neuroectodermal tumor 10.4 SYP S100B
11 angiocentric glioma 10.4 SYP S100B
12 pineocytoma 10.4 SYP S100B
13 cellular schwannoma 10.4 S100B PAX8
14 malignant teratoma 10.4 SYP AVP
15 papillary ependymoma 10.4 SYP S100B
16 reticular perineurioma 10.4 S100B KIT
17 olfactory nerve neoplasm 10.4 SYP AVP
18 perineurioma 10.4 S100B KIT
19 papilloma of choroid plexus 10.4 SYP S100B
20 ectopic thymus 10.4 SYP CD5
21 sarcomatoid renal cell carcinoma 10.4 PAX8 KIT
22 subependymal giant cell astrocytoma 10.4 SYP S100B
23 rete testis neoplasm 10.3 PAX8 KIT
24 cervix small cell carcinoma 10.3 SYP AVP
25 cerebral primitive neuroectodermal tumor 10.3 SYP S100B
26 amelanotic melanoma 10.3 S100B KIT
27 prostatic acinar adenocarcinoma 10.3 PAX8 KIT
28 thymic epithelial tumor 10.3 KIT CD5
29 dental abscess 10.3 KIT AVP
30 olfactory neuroblastoma 10.3 SYP S100B
31 thymus lipoma 10.3 SYP CD5
32 ectopic cushing syndrome 10.3 SYP S100B
33 embryonal sarcoma 10.3 S100B KIT
34 cranial nerve malignant neoplasm 10.3 SYP AVP
35 lymphoepithelioma-like thymic carcinoma 10.3 KIT CD5
36 hydromyelia 10.3 S100B PTEN
37 immune system organ benign neoplasm 10.3 SYP CD5
38 tracheoesophageal fistula 10.3 SYP S100B
39 gemistocytic astrocytoma 10.3 S100B PTEN
40 optic nerve glioma 10.3 SYP S100B
41 polymorphous low-grade adenocarcinoma 10.3 S100B KIT
42 cutaneous ganglioneuroma 10.3 SYP KIT
43 endometrial small cell carcinoma 10.2 SYP KIT
44 ganglioglioma 10.2 SYP S100B
45 necrotizing sialometaplasia 10.2 KIT CD5
46 angiomyoma 10.2 SYP KIT
47 perivascular epithelioid cell tumor 10.2 SYP KIT
48 ovarian brenner tumor 10.2 PAX8 KIT
49 functional colonic disease 10.2 SYP KIT
50 chronic maxillary sinusitis 10.2 SYP PDPN

Graphical network of the top 20 diseases related to Mixed Type Thymoma:



Diseases related to Mixed Type Thymoma

Symptoms & Phenotypes for Mixed Type Thymoma

MGI Mouse Phenotypes related to Mixed Type Thymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 AVP KIT PAX8 PDPN PTEN S100B
2 integument MP:0010771 9.35 CD5 KIT PDPN PTEN S100B
3 normal MP:0002873 9.23 ALPG AVP CD5 KIT PAX8 PTEN

Drugs & Therapeutics for Mixed Type Thymoma

Search Clinical Trials , NIH Clinical Center for Mixed Type Thymoma

Genetic Tests for Mixed Type Thymoma

Anatomical Context for Mixed Type Thymoma

MalaCards organs/tissues related to Mixed Type Thymoma:

41
Lung

Publications for Mixed Type Thymoma

Articles related to Mixed Type Thymoma:

(show all 27)
# Title Authors PMID Year
1
Prognostic value of immunohistochemical markers in malignant thymic epithelial tumors. 38
27747012 2016
2
Concurrent thymoma, thymic carcinoma, and T lymphoblastic leukemia/lymphoma in an anterior mediastinal mass. 38
26150396 2015
3
Establishment and characterization of a novel cell line derived from thymoma with myasthenia gravis patients. 38
26273358 2015
4
Successful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases. 38
26521902 2015
5
Associated immunological disorders and cellular immune dysfunction in thymoma: a study of 87 cases from Thailand. 38
23229679 2013
6
A case of middle mediastinal thymoma. 38
22610165 2012
7
18F-fluorodeoxyglucose and 11C-acetate positron emission tomography are useful modalities for diagnosing the histologic type of thymoma. 38
19326456 2009
8
[Recurrence of thymoma as pleural dissemination 23-years after surgery]. 38
19195191 2009
9
[Long-term prognostic analysis of surgical treatment of the thymoma-associated myasthenia gravis]. 38
19668149 2009
10
Recurrent myasthenia gravis due to a pleural implant 3 years after radical thymectomy. 38
18573446 2008
11
Malignant thymoma associated with myasthenia gravis, Graves' disease, and SIADH. 38
18520111 2008
12
Ring chromosome 6 may represent a cytogenetic subgroup in benign thymoma. 38
12377419 2002
13
[A case of thymoma with pure red cell aplasia]. 38
11761906 2001
14
Minimally invasive thymoma with extensive intravascular growth. 38
10721946 1999
15
Dermatomyositis associated with invasive thymoma. 38
10225672 1999
16
Thymic lymphoepithelioma-like carcinoma associated with thymoma in a patient with ocular myasthenia. 38
9636966 1998
17
[A case of thymic cyst and thymoma with myasthenia gravis]. 38
9330525 1997
18
Preoperative intra-arterial infusion chemotherapy for invasive thymoma: a case report. 38
9001356 1996
19
A rare case of typical carcinoid of the lung coincident with thymoma. 38
7967108 1994
20
[A case of thymoma showing extensive necrosis]. 38
8409618 1993
21
Thymoma: a study of the pathologic classification of 71 cases with evaluation of the Muller-Hermelink system. 38
8319955 1993
22
[A case of thymoma with thymic cyst]. 38
1431407 1992
23
Adenine nucleotide content of thymoma-derived lymphocytes. 38
1519315 1992
24
[Two cases of post-thymectomy myasthenia gravis]. 38
1402200 1992
25
An immunohistochemical study of thymic epithelial tumors. III. The distribution of interdigitating reticulum cells and S-100 beta-positive small lymphocytes. 38
2252104 1990
26
Multiple clonal chromosome aberrations in two thymomas. 38
2766255 1989
27
Multiple thymic squamous cell carcinomas associated with mixed type thymoma. 38
3688303 1987

Variations for Mixed Type Thymoma

Expression for Mixed Type Thymoma

Search GEO for disease gene expression data for Mixed Type Thymoma.

Pathways for Mixed Type Thymoma

Pathways related to Mixed Type Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 SYP S100B AVP
2 10.35 KIT CD5

GO Terms for Mixed Type Thymoma

Cellular components related to Mixed Type Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 PTEN KIT

Biological processes related to Mixed Type Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.67 S100B PTEN KIT AVP
2 negative regulation of apoptotic process GO:0043066 9.58 PTEN PDPN AVP
3 learning or memory GO:0007611 9.48 S100B PTEN
4 social behavior GO:0035176 9.46 PTEN AVP
5 long-term synaptic potentiation GO:0060291 9.43 S100B PTEN
6 regulation of cell shape GO:0008360 9.33 S100B PDPN KIT
7 regulation of neuronal synaptic plasticity GO:0048168 9.32 SYP S100B
8 water transport GO:0006833 9.26 PDPN AVP
9 maternal behavior GO:0042711 8.96 PTEN AVP
10 central nervous system development GO:0007417 8.8 S100B PTEN PAX8

Sources for Mixed Type Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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