MCID: MBT001
MIFTS: 34

Mobitz Type Ii Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Mobitz Type Ii Atrioventricular Block

MalaCards integrated aliases for Mobitz Type Ii Atrioventricular Block:

Name: Mobitz Type Ii Atrioventricular Block 12 15 71
Mobitz Ii Atrioventricular Block 12
Mobitz Ii Atrioventricular Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11312
ICD9CM 34 426.12
NCIt 50 C62018
SNOMED-CT 67 28189009
UMLS 71 C0155700

Summaries for Mobitz Type Ii Atrioventricular Block

MalaCards based summary : Mobitz Type Ii Atrioventricular Block, also known as mobitz ii atrioventricular block, is related to atrioventricular block and congestive heart failure. An important gene associated with Mobitz Type Ii Atrioventricular Block is TCN2 (Transcobalamin 2), and among its related pathways/superpathways are RhoGDI Pathway and Dilated cardiomyopathy. Affiliated tissues include heart and uterus, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Mobitz Type Ii Atrioventricular Block

Diseases related to Mobitz Type Ii Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 31.4 MYH7 LMNA ACE
2 congestive heart failure 30.0 TNNT2 MYH7 MYH6 CRP ACE
3 heart disease 28.3 TNNT2 MYH7 MYH6 LMNA KDR ENG
4 progressive familial heart block, type ia 10.4
5 progressive familial heart block, type ib 10.4
6 right bundle branch block 10.4
7 acute dacryoadenitis 10.4 CRP ACE
8 mediastinum teratoma 10.4 CRP ACE
9 glomerular disease 10.4 AMBP ACE
10 cardiac tuberculosis 10.4 CRP ACE
11 anterior scleritis 10.4 CRP ACE
12 multiple cranial nerve palsy 10.4 CRP ACE
13 posterior scleritis 10.4 CRP ACE
14 tolosa-hunt syndrome 10.4 CRP ACE
15 olecranon bursitis 10.4 KDR CRP
16 pulmonary vein stenosis 10.3 KDR ACTC1
17 chlorhexidine allergy 10.3 CD34 ACE
18 chronic orbital inflammation 10.3 CRP ACE
19 glomangiomyoma 10.3 CD34 ACTC1
20 glossopharyngeal nerve disease 10.3 CRP ACE
21 granulomatous angiitis 10.3 CRP ACE
22 urinary tract infection 10.3 CRP ACE
23 neuroretinitis 10.3 CRP ACE
24 breast angiosarcoma 10.3 KDR CD34
25 liver inflammatory pseudotumor 10.3 CRP CD34
26 kaposiform hemangioendothelioma 10.3 KDR CD34
27 cholesterol embolism 10.3 CRP ACE
28 optic papillitis 10.3 CRP ACE
29 granulomatous hepatitis 10.3 CRP ACE
30 cutaneous leiomyosarcoma 10.3 CD34 ACTC1
31 angiokeratoma circumscriptum 10.3 KDR CD34
32 mononeuritis of upper limb and mononeuritis multiplex 10.3 CRP ACE
33 mononeuritis multiplex 10.3 CRP ACE
34 generalized atherosclerosis 10.3 CRP ACE
35 subungual glomus tumor 10.3 CRP CD34
36 rheumatic myocarditis 10.3 TNNT2 CRP
37 potter's syndrome 10.3 CD34 ACE
38 background diabetic retinopathy 10.3 KDR CRP ACE
39 angiolipoma 10.3 CD34 ACTC1
40 glomangioma 10.2 CD34 ACTC1
41 capillary hemangioma 10.2 PROM1 KDR CD34
42 epithelioid hemangioendothelioma 10.2 KDR ACTC1
43 capillary disease 10.2 PROM1 KDR CD34
44 cardiac arrhythmia 10.2
45 stroke, ischemic 10.2
46 second-degree atrioventricular block 10.2
47 viral pneumonia 10.2
48 thrombocytopenia 10.2
49 ischemia 10.2
50 systolic heart failure 10.2

Comorbidity relations with Mobitz Type Ii Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Aortic Valve Disease 1
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Right Bundle Branch Block Sinoatrial Node Disease
Third-Degree Atrioventricular Block

Graphical network of the top 20 diseases related to Mobitz Type Ii Atrioventricular Block:



Diseases related to Mobitz Type Ii Atrioventricular Block

Symptoms & Phenotypes for Mobitz Type Ii Atrioventricular Block

GenomeRNAi Phenotypes related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.6 KDR
2 Decreased viability GR00221-A-2 9.6 KDR
3 Decreased viability GR00221-A-3 9.6 KDR
4 Decreased viability GR00221-A-4 9.6 KDR
5 Decreased viability GR00240-S-1 9.6 LMNA
6 Decreased viability GR00249-S 9.6 FGF7 HBEGF KDR LMNA THY1 TNNT2
7 Decreased viability GR00381-A-1 9.6 LDB3 MCAM
8 Decreased viability GR00386-A-1 9.6 AMBP FGF7 LMNA MYH6 TCN2
9 Decreased viability GR00402-S-2 9.6 THY1

MGI Mouse Phenotypes related to Mobitz Type Ii Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ACE ACTC1 CRP ENG HBEGF KDR
2 behavior/neurological MP:0005386 10.15 ACE AMBP ENG FGF7 HBEGF KDR
3 homeostasis/metabolism MP:0005376 10.13 ACE ACTC1 CD34 CRP ENG FGF7
4 muscle MP:0005369 9.81 ACTC1 ENG HBEGF KDR LDB3 LMNA
5 nervous system MP:0003631 9.7 ACE ACTC1 ENG FGF7 HBEGF KDR
6 normal MP:0002873 9.28 ACTC1 ENG HBEGF KDR LMNA MYH7

Drugs & Therapeutics for Mobitz Type Ii Atrioventricular Block

Search Clinical Trials , NIH Clinical Center for Mobitz Type Ii Atrioventricular Block

Genetic Tests for Mobitz Type Ii Atrioventricular Block

Anatomical Context for Mobitz Type Ii Atrioventricular Block

MalaCards organs/tissues related to Mobitz Type Ii Atrioventricular Block:

40
Heart, Uterus

Publications for Mobitz Type Ii Atrioventricular Block

Articles related to Mobitz Type Ii Atrioventricular Block:

(show all 43)
# Title Authors PMID Year
1
Mobitz Type II Atrioventricular Heart Block After Candlenut Ingestion. 61
33017016 2020
2
Incomplete Trifascicular Block and Mobitz Type II Atrioventricular Block in COVID-19. 61
33083164 2020
3
Routine Continuous Electrocardiographic Monitoring Following Percutaneous Coronary Interventions. 61
31884835 2020
4
Left bundle branch pacing from distal His-bundle region by tricuspid valve annulus angiography. 61
31544273 2019
5
A case report positive for synthetic cannabinoids: are cardiovascular effects related to their protracted use? 61
31683096 2019
6
How much can synthetic cannabinoid damage the heart? A case of cardiogenic shock following resistant ventricular fibrillation after synthetic cannabinoid use. 61
29479764 2018
7
Intraoperative Device Closure of Isolated Ventricular Septal Defects: Experience on 1,090 Cases. 61
29596821 2018
8
Mobitz Type II Atrioventricular Block following Tramadol and Fentanyl in a Patient with Acute Coronary Syndrome and Systolic Heart Failure. 61
29184615 2017
9
Conduction Disorders After Sutureless Aortic Valve Replacement. 61
27717423 2017
10
A Mobitz type II atrioventricular block in multicentric ischemic stroke. 61
28154620 2016
11
A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. 61
26536992 2015
12
Intraarrest rhythms and rhythm conversion in asphyxial cardiac arrest. 61
25903291 2015
13
Chest pain with minimal activities and flexion of trunk: a rare case of angina. 61
23442815 2015
14
Closure of perimembranous ventricular septal defects with intraoperative device technique: another safe alternative to surgical repair. 61
22684414 2013
15
Mobitz Type II Atrioventricular Block Followed by Remifentanil in a Patient with Severe Aortic Stenosis. 61
23662214 2013
16
Severe tricuspid regurgitation and atrioventicular block caused by blunt thoracic trauma in an elderly woman. 61
20851553 2012
17
Dual-chamber pacemaker malfunction mimicking atrial capture by the ventricular electrode. 61
21478130 2011
18
[Mobitz type II block during one-lung ventilation]. 61
20229756 2010
19
Alternating bundle branch block together with alternation of PR intervals: advanced Mobitz II atrioventricular block. 61
20495518 2010
20
Kikuchi-Fujimoto disease manifesting as recurrent thrombocytopenia and Mobitz type II atrioventricular block in a 7-year-old girl: a case report and analysis of 138 Chinese childhood Kikuchi-Fujimoto cases with 10 years of follow-up in 97 patients. 61
17931395 2007
21
Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel. 61
17223814 2007
22
Persistent left-sided superior vena cava--a pacing challenge. 61
18030627 2007
23
Effect of biventricular pacing on left ventricular outflow tract pressure gradient in a patient with hypertrophic cardiomyopathy and normal interventricular conduction. 61
16533259 2006
24
A case of alternating bundle branch block in combination with intra-Hisian block. 61
16157965 2005
25
Possible complications of subclavian crush syndrome. 61
25696461 2005
26
Octreotide-induced bradycardia and heart block during surgical resection of a carcinoid tumor. 61
14742361 2004
27
[Definitions of second degree atrioventricular block. An exercise in logic in clinical electrocardiography]. 61
11107481 2000
28
Supernormal conduction in a case of Mobitz type II atrioventricular block. 61
9533380 1998
29
[Case report of coronary artery bypass performed on a patient implanted with a single-lead atrial triggered ventricular VDD pacemaker]. 61
9071145 1997
30
[Mobitz type II atrioventricular block as a side effect of pentoxifylline]. 61
8926709 1996
31
Failure of the circulatory system limits exercise performance in patients with systemic sclerosis. 61
8213874 1993
32
Functional dissociation of cellular activation as a mechanism of Mobitz type II atrioventricular block. 61
8462160 1993
33
Cough syncope presenting as Mobitz type II atrioventricular block--an electrophysiologic correlation. 61
2436170 1987
34
A simplified method to predict occurrence of complete heart block during acute myocardial infarction. 61
3717016 1986
35
Cardiac arrhythmias in the elderly: clinical aspects. 61
2423243 1986
36
Reentrant tachycardia associated with atrial synchronous pacing. Report of a case with intact ventriculoatrial conduction. 61
6887977 1983
37
The "holiday heart": electrophysiologic studies of alcohol effects in alcoholics. 61
6824246 1983
38
Clinical and electrophysiologic findings in patients with paroxysmal slowing of the sinus rate and apparent Mobitz type II atrioventricular block. 61
668079 1978
39
[A case of Mobitz type II atrioventricular block diagnosed in uterus]. 61
747830 1978
40
Mobitz II atrioventricular block due to infra-Hisian block and bundle branch extrasystoles. 61
57202 1976
41
Tachycardia-dependent and bradycardia-dependent Mobitz type II atrioventricular block within the bundle of His. 61
4829374 1974
42
Mobitz type II atrioventricular block in a newborn. 61
5045362 1972
43
Mobitz type II atrioventricular block in children. 61
5132309 1971

Variations for Mobitz Type Ii Atrioventricular Block

Expression for Mobitz Type Ii Atrioventricular Block

Search GEO for disease gene expression data for Mobitz Type Ii Atrioventricular Block.

Pathways for Mobitz Type Ii Atrioventricular Block

Pathways related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 MYH7 MYH6 KDR FGF7
2
Show member pathways
11.9 TNNT2 MYH7 MYH6 LMNA ACTC1 ACE
3 11.75 TNNT2 PROM1 KDR FGF7
4 11.5 TNNT2 MYH7 MYH6 ACTC1
5 11.4 TNNT2 MYH6 ACTC1
6 11.08 TNNT2 THY1 MYH6 KDR ACTC1
7 11.08 TNNT2 THY1 MCAM HBEGF ENG CD34

GO Terms for Mobitz Type Ii Atrioventricular Block

Cellular components related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 THY1 TCN2 OXT MCAM KDR HBEGF
2 external side of plasma membrane GO:0009897 9.77 THY1 MCAM ENG CD34 ACE
3 cell surface GO:0009986 9.73 THY1 PROM1 HBEGF ENG CD34 AMBP
4 stress fiber GO:0001725 9.58 MYH7 MYH6 LDB3
5 myofibril GO:0030016 9.5 TNNT2 MYH7 MYH6
6 muscle myosin complex GO:0005859 9.43 MYH7 MYH6
7 extracellular space GO:0005615 9.36 TCN2 PROM1 OXT MCAM HBEGF FGF7
8 sarcomere GO:0030017 9.26 TNNT2 MYH7 MYH6 ACTC1

Biological processes related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.81 THY1 MCAM KDR ENG
2 positive regulation of gene expression GO:0010628 9.8 LMNA FGF7 ENG CRP CD34 ACTC1
3 regulation of cell migration GO:0030334 9.77 THY1 LMNA FGF7
4 regulation of blood pressure GO:0008217 9.67 MYH6 CD34 ACE
5 sarcomere organization GO:0045214 9.61 TNNT2 MYH6 LDB3
6 heart contraction GO:0060047 9.59 ACTC1 ACE
7 striated muscle contraction GO:0006941 9.58 MYH7 MYH6
8 glomerular filtration GO:0003094 9.58 MCAM CD34
9 regulation of heart contraction GO:0008016 9.58 TNNT2 MYH6 HBEGF
10 cardiac muscle hypertrophy in response to stress GO:0014898 9.57 MYH7 MYH6
11 adult heart development GO:0007512 9.56 MYH7 MYH6
12 positive regulation of systemic arterial blood pressure GO:0003084 9.55 ENG ACE
13 positive regulation of vasculogenesis GO:2001214 9.54 KDR CD34
14 regulation of heart rate GO:0002027 9.54 OXT MYH7 MYH6
15 positive regulation of keratinocyte migration GO:0051549 9.52 HBEGF FGF7
16 atrial cardiac muscle tissue morphogenesis GO:0055009 9.48 MYH6 ENG
17 endothelium development GO:0003158 9.46 KDR CD34
18 cardiac muscle contraction GO:0060048 9.46 TNNT2 MYH7 MYH6 ACTC1
19 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.43 TNNT2 MYH7 MYH6
20 vascular wound healing GO:0061042 9.13 MCAM KDR CD34
21 muscle filament sliding GO:0030049 8.92 TNNT2 MYH7 MYH6 ACTC1

Molecular functions related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.26 TNNT2 MYH7 MYH6 ACTC1
2 actin binding GO:0003779 9.02 TNNT2 MYH7 MYH6 LDB3 ACE

Sources for Mobitz Type Ii Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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