MCID: MBT001
MIFTS: 31

Mobitz Type Ii Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Mobitz Type Ii Atrioventricular Block

MalaCards integrated aliases for Mobitz Type Ii Atrioventricular Block:

Name: Mobitz Type Ii Atrioventricular Block 12 15 71
Mobitz Ii Atrioventricular Block 12
Mobitz Ii Atrioventricular Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11312
ICD9CM 34 426.12
NCIt 49 C62018
SNOMED-CT 67 28189009
UMLS 71 C0155700

Summaries for Mobitz Type Ii Atrioventricular Block

MalaCards based summary : Mobitz Type Ii Atrioventricular Block, also known as mobitz ii atrioventricular block, is related to atrioventricular block and dermatitis, atopic, 7. An important gene associated with Mobitz Type Ii Atrioventricular Block is TCN2 (Transcobalamin 2), and among its related pathways/superpathways are Sphingolipid signaling pathway and S1P3 pathway. Affiliated tissues include heart, lung and uterus, and related phenotype is cardiovascular system.

Related Diseases for Mobitz Type Ii Atrioventricular Block

Diseases related to Mobitz Type Ii Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 10.8
2 dermatitis, atopic, 7 10.4 SPHK2 S1PR3
3 mediastinum teratoma 10.3 CRP ACE
4 transcobalamin ii deficiency 10.3 TCN2 TCN1
5 olecranon bursitis 10.3 KDR CRP
6 glomerular disease 10.3 AMBP ACE
7 acute dacryoadenitis 10.3 CRP ACE
8 bursitis 10.3 KDR CRP
9 chronic orbital inflammation 10.3 CRP ACE
10 multiple cranial nerve palsy 10.3 CRP ACE
11 anterior scleritis 10.3 CRP ACE
12 posterior scleritis 10.3 CRP ACE
13 tolosa-hunt syndrome 10.3 CRP ACE
14 vitamin metabolic disorder 10.3 TCN2 TCN1 CRP
15 kaposiform hemangioendothelioma 10.3 KDR CD34
16 breast angiosarcoma 10.2 KDR CD34
17 silent myocardial infarction 10.2 CRP ACE
18 granulomatous angiitis 10.2 CRP ACE
19 progressive familial heart block, type ia 10.2
20 cardiac arrhythmia 10.2
21 stroke, ischemic 10.2
22 progressive familial heart block, type ib 10.2
23 right bundle branch block 10.2
24 thrombocytopenia 10.2
25 ischemia 10.2
26 cerebrovascular disease 10.2
27 systolic heart failure 10.2
28 syncope 10.2
29 serotonin syndrome 10.2
30 neuroretinitis 10.2 CRP ACE
31 liver inflammatory pseudotumor 10.2 CRP CD34
32 optic papillitis 10.2 CRP ACE
33 second-degree atrioventricular block 10.2
34 granulomatous hepatitis 10.2 CRP ACE
35 angiokeratoma circumscriptum 10.2 KDR CD34
36 cholesterol embolism 10.2 CRP ACE
37 generalized atherosclerosis 10.2 CRP ACE
38 neurosarcoidosis 10.2 CRP ACE
39 bacterial conjunctivitis 10.2 GPR182 CRP
40 macular retinal edema 10.2 S1PR3 KDR ACE
41 cat-scratch disease 10.2 CRP ACE
42 hypertensive nephropathy 10.1 AMBP ACE
43 capillary lymphangioma 10.1 CRP CD34
44 intracranial embolism 10.1 CRP ACE
45 capillary disease 10.1 PROM1 KDR CD34
46 capillary hemangioma 10.1 PROM1 KDR CD34
47 first-degree atrioventricular block 10.1 CRP ACE
48 parasitic protozoa infectious disease 10.1 TCN2 KDR CRP
49 cerebral atherosclerosis 10.1 CRP ACE
50 hemangioblastoma 10.1 PROM1 KDR CD34

Comorbidity relations with Mobitz Type Ii Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Aortic Valve Disease 1
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Right Bundle Branch Block Sinoatrial Node Disease
Third-Degree Atrioventricular Block

Graphical network of the top 20 diseases related to Mobitz Type Ii Atrioventricular Block:



Diseases related to Mobitz Type Ii Atrioventricular Block

Symptoms & Phenotypes for Mobitz Type Ii Atrioventricular Block

MGI Mouse Phenotypes related to Mobitz Type Ii Atrioventricular Block:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 ACE CRP HBEGF KDR MCAM OXT

Drugs & Therapeutics for Mobitz Type Ii Atrioventricular Block

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2

Search NIH Clinical Center for Mobitz Type Ii Atrioventricular Block

Genetic Tests for Mobitz Type Ii Atrioventricular Block

Anatomical Context for Mobitz Type Ii Atrioventricular Block

MalaCards organs/tissues related to Mobitz Type Ii Atrioventricular Block:

40
Heart, Lung, Uterus

Publications for Mobitz Type Ii Atrioventricular Block

Articles related to Mobitz Type Ii Atrioventricular Block:

(show all 40)
# Title Authors PMID Year
1
Left bundle branch pacing from distal His-bundle region by tricuspid valve annulus angiography. 61
31544273 2019
2
A case report positive for synthetic cannabinoids: are cardiovascular effects related to their protracted use? 61
31683096 2019
3
How much can synthetic cannabinoid damage the heart? A case of cardiogenic shock following resistant ventricular fibrillation after synthetic cannabinoid use. 61
29479764 2018
4
Intraoperative Device Closure of Isolated Ventricular Septal Defects: Experience on 1,090 Cases. 61
29596821 2018
5
Mobitz Type II Atrioventricular Block following Tramadol and Fentanyl in a Patient with Acute Coronary Syndrome and Systolic Heart Failure. 61
29184615 2017
6
Conduction Disorders After Sutureless Aortic Valve Replacement. 61
27717423 2017
7
A Mobitz type II atrioventricular block in multicentric ischemic stroke. 61
28154620 2016
8
A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. 61
26536992 2015
9
Intraarrest rhythms and rhythm conversion in asphyxial cardiac arrest. 61
25903291 2015
10
Chest pain with minimal activities and flexion of trunk: a rare case of angina. 61
23442815 2015
11
Closure of perimembranous ventricular septal defects with intraoperative device technique: another safe alternative to surgical repair. 61
22684414 2013
12
Mobitz Type II Atrioventricular Block Followed by Remifentanil in a Patient with Severe Aortic Stenosis. 61
23662214 2013
13
Severe tricuspid regurgitation and atrioventicular block caused by blunt thoracic trauma in an elderly woman. 61
20851553 2012
14
Dual-chamber pacemaker malfunction mimicking atrial capture by the ventricular electrode. 61
21478130 2011
15
[Mobitz type II block during one-lung ventilation]. 61
20229756 2010
16
Alternating bundle branch block together with alternation of PR intervals: advanced Mobitz II atrioventricular block. 61
20495518 2010
17
Kikuchi-Fujimoto disease manifesting as recurrent thrombocytopenia and Mobitz type II atrioventricular block in a 7-year-old girl: a case report and analysis of 138 Chinese childhood Kikuchi-Fujimoto cases with 10 years of follow-up in 97 patients. 61
17931395 2007
18
Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel. 61
17223814 2007
19
Persistent left-sided superior vena cava--a pacing challenge. 61
18030627 2007
20
Effect of biventricular pacing on left ventricular outflow tract pressure gradient in a patient with hypertrophic cardiomyopathy and normal interventricular conduction. 61
16533259 2006
21
A case of alternating bundle branch block in combination with intra-Hisian block. 61
16157965 2005
22
Possible complications of subclavian crush syndrome. 61
25696461 2005
23
Octreotide-induced bradycardia and heart block during surgical resection of a carcinoid tumor. 61
14742361 2004
24
[Definitions of second degree atrioventricular block. An exercise in logic in clinical electrocardiography]. 61
11107481 2000
25
Supernormal conduction in a case of Mobitz type II atrioventricular block. 61
9533380 1998
26
[Case report of coronary artery bypass performed on a patient implanted with a single-lead atrial triggered ventricular VDD pacemaker]. 61
9071145 1997
27
[Mobitz type II atrioventricular block as a side effect of pentoxifylline]. 61
8926709 1996
28
Failure of the circulatory system limits exercise performance in patients with systemic sclerosis. 61
8213874 1993
29
Functional dissociation of cellular activation as a mechanism of Mobitz type II atrioventricular block. 61
8462160 1993
30
Cough syncope presenting as Mobitz type II atrioventricular block--an electrophysiologic correlation. 61
2436170 1987
31
A simplified method to predict occurrence of complete heart block during acute myocardial infarction. 61
3717016 1986
32
Cardiac arrhythmias in the elderly: clinical aspects. 61
2423243 1986
33
Reentrant tachycardia associated with atrial synchronous pacing. Report of a case with intact ventriculoatrial conduction. 61
6887977 1983
34
The "holiday heart": electrophysiologic studies of alcohol effects in alcoholics. 61
6824246 1983
35
Clinical and electrophysiologic findings in patients with paroxysmal slowing of the sinus rate and apparent Mobitz type II atrioventricular block. 61
668079 1978
36
[A case of Mobitz type II atrioventricular block diagnosed in uterus]. 61
747830 1978
37
Mobitz II atrioventricular block due to infra-Hisian block and bundle branch extrasystoles. 61
57202 1976
38
Tachycardia-dependent and bradycardia-dependent Mobitz type II atrioventricular block within the bundle of His. 61
4829374 1974
39
Mobitz type II atrioventricular block in a newborn. 61
5045362 1972
40
Mobitz type II atrioventricular block in children. 61
5132309 1971

Variations for Mobitz Type Ii Atrioventricular Block

Expression for Mobitz Type Ii Atrioventricular Block

Search GEO for disease gene expression data for Mobitz Type Ii Atrioventricular Block.

Pathways for Mobitz Type Ii Atrioventricular Block

Pathways related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 SPHK2 S1PR3 S1PR2
2
Show member pathways
11.32 SPHK2 S1PR3 S1PR2 KDR
3 10.3 S1PR3 S1PR2
4 10.21 SPHK2 S1PR3 S1PR2

GO Terms for Mobitz Type Ii Atrioventricular Block

Cellular components related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TCN2 TCN1 PROM1 OXT MCAM HBEGF
2 extracellular region GO:0005576 9.4 TCN2 TCN1 S1PR3 OXT MCAM KDR

Biological processes related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 S1PR3 S1PR2 REM1 OXT HBEGF GPR182
2 female pregnancy GO:0007565 9.65 SPHK2 OXT AMBP
3 positive regulation of keratinocyte migration GO:0051549 9.46 HBEGF FGF7
4 glomerular filtration GO:0003094 9.43 MCAM CD34
5 positive regulation of cell proliferation GO:0008284 9.43 SPHK2 S1PR3 S1PR2 KDR HBEGF FGF7
6 positive regulation of vasculogenesis GO:2001214 9.4 KDR CD34
7 cobalamin transport GO:0015889 9.37 TCN2 TCN1
8 cobalt ion transport GO:0006824 9.32 TCN2 TCN1
9 endothelium development GO:0003158 9.26 KDR CD34
10 vascular wound healing GO:0061042 9.16 MCAM CD34
11 sphingosine-1-phosphate receptor signaling pathway GO:0003376 8.8 SPHK2 S1PR3 S1PR2

Molecular functions related to Mobitz Type Ii Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cobalamin binding GO:0031419 8.96 TCN2 TCN1
2 sphingosine-1-phosphate receptor activity GO:0038036 8.8 SPHK2 S1PR3 S1PR2

Sources for Mobitz Type Ii Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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