MCID: MDR006
MIFTS: 23

Moderate and Severe Traumatic Brain Injury

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

Summaries for Moderate and Severe Traumatic Brain Injury

MalaCards based summary : Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drugs Mannitol and Morphine have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Moderate and Severe Traumatic Brain Injury

Graphical network of the top 20 diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to Moderate and Severe Traumatic Brain Injury

Symptoms & Phenotypes for Moderate and Severe Traumatic Brain Injury

Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

Drugs for Moderate and Severe Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4 Central Nervous System Depressants Phase 4,Phase 2
5 Adjuvants, Anesthesia Phase 4
6 GABA Agents Phase 4
7 GABA Modulators Phase 4
8 Neurotransmitter Agents Phase 4
9 Hemostatics Phase 4,Phase 3
10 Anesthetics Phase 4,Phase 2
11 Anesthetics, General Phase 4
12 Anesthetics, Intravenous Phase 4
13 Tranquilizing Agents Phase 4
14 Anti-Anxiety Agents Phase 4
15 Hypnotics and Sedatives Phase 4
16 Psychotropic Drugs Phase 4
17
Tranexamic Acid Approved Phase 3 1197-18-8 5526
18
Choline Approved, Nutraceutical Phase 3 62-49-7 305
19 Coagulants Phase 3
20 Pharmaceutical Solutions Phase 3,Phase 2
21 Antifibrinolytic Agents Phase 3
22 Cytidine Diphosphate Choline Phase 3
23 Nootropic Agents Phase 3
24 Ether Phase 2
25 Pregnanolone Phase 2 128-20-1
26 Estradiol valerate Approved, Investigational, Vet_approved Not Applicable 979-32-8
27
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
28
Testosterone Approved, Investigational Not Applicable 58-22-0 6013
29
Polyestradiol phosphate Approved Not Applicable 28014-46-2
30 Hormones Not Applicable
31 glucagon Not Applicable
32 beta-endorphin Not Applicable
33 Follicle Stimulating Hormone Not Applicable
34 Adrenocorticotropic Hormone Not Applicable
35 Glucagon-Like Peptide 1 Not Applicable
36 Estradiol 17 beta-cypionate Not Applicable
37 Estradiol 3-benzoate Not Applicable
38 Melanocyte-Stimulating Hormones Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
2 Citicholine-Amantadine Trial in Traumatic Brain Injury Active, not recruiting NCT03430817 Phase 4 Citicholine;Amantadine
3 Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury Unknown status NCT02645552 Phase 3 Tranexamic Acid
4 Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury Recruiting NCT02794168 Phase 3 VAS203;Saline
5 Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) Terminated NCT00545662 Phase 3 Placebo;citicoline
6 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
7 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2 Allopregnanolone injection;Placebo injection
8 A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury. Terminated NCT00735085 Phase 2 SLV334;SLV334;SLV334;SLV334;Placebo
9 Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury Unknown status NCT01512524 Not Applicable
10 Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury Completed NCT01955785 Not Applicable
11 Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury Recruiting NCT03169647 Not Applicable
12 The PIT-TBI Pilot Study Active, not recruiting NCT02480985 Not Applicable

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

Anatomical Context for Moderate and Severe Traumatic Brain Injury

MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

41
Brain

Publications for Moderate and Severe Traumatic Brain Injury

Articles related to Moderate and Severe Traumatic Brain Injury:

# Title Authors Year
1
Characteristics of Moderate and Severe Traumatic Brain Injury of Motorcycle Crashes in Bandung, Indonesia. ( 28087431 )
2017
2
Management of Spasticity in Moderate and Severe Traumatic Brain Injury: Evaluation of Clinical Practice Guidelines. ( 27120291 )
2016
3
Moderate and severe traumatic brain injury: effect of blood alcohol concentration on Glasgow Coma Scale score and relation to computed tomography findings. ( 25361494 )
2015
4
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. ( 24139087 )
2014
5
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. ( 24378157 )
2013
6
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. ( 22511138 )
2012
7
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. ( 16525069 )
2006
8
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. ( 16614010 )
2006

Variations for Moderate and Severe Traumatic Brain Injury

Expression for Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for Moderate and Severe Traumatic Brain Injury

Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 ACE APOE

GO Terms for Moderate and Severe Traumatic Brain Injury

Sources for Moderate and Severe Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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