MCID: MDR006
MIFTS: 27

Moderate and Severe Traumatic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

MalaCards integrated aliases for Moderate and Severe Traumatic Brain Injury:

Name: Moderate and Severe Traumatic Brain Injury 58

Characteristics:

Orphanet epidemiological data:

58
moderate and severe traumatic brain injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA90056

Summaries for Moderate and Severe Traumatic Brain Injury

MalaCards based summary : Moderate and Severe Traumatic Brain Injury is related to traumatic brain injury and brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drugs Midazolam and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and temporal lobe.

Related Diseases for Moderate and Severe Traumatic Brain Injury

Diseases related to Moderate and Severe Traumatic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 11.1
2 brain injury 11.1
3 ocular motor apraxia 10.8
4 head injury 10.6
5 amnestic disorder 10.5
6 intracranial hypertension 10.3
7 cerebral hypoxia 10.3
8 anisocoria 10.1
9 osteoporosis 10.1
10 thrombophilia due to thrombin defect 10.1
11 pulmonary disease, chronic obstructive 10.1
12 bone mineral density quantitative trait locus 8 10.1
13 bone mineral density quantitative trait locus 15 10.1
14 temporal lobe epilepsy 10.1
15 hyperglycemia 10.1
16 47,xyy 10.1
17 48,xyyy 10.1
18 cerebral atrophy 10.1
19 headache 10.1
20 persistent vegetative state 10.1
21 seizure disorder 10.1
22 spasticity 10.1
23 generalized atherosclerosis 9.9 APOE ACE
24 intracranial vasospasm 9.9 APOE ACE
25 mild cognitive impairment 9.9 APOE ACE
26 idiopathic nephrotic syndrome 9.9 APOE ACE
27 nephrotic syndrome 9.9 APOE ACE
28 cerebral atherosclerosis 9.9 APOE ACE
29 hemorrhage, intracerebral 9.9 APOE ACE
30 coronary heart disease 1 9.9 APOE ACE
31 apnea, obstructive sleep 9.9 APOE ACE
32 aortic atherosclerosis 9.9 APOE ACE
33 carotid stenosis 9.9 APOE ACE
34 coronary stenosis 9.9 APOE ACE
35 carotid artery disease 9.8 APOE ACE
36 peripheral artery disease 9.8 APOE ACE
37 normal pressure hydrocephalus 9.8 APOE ACE
38 hydrocephalus 9.8 APOE ACE
39 sleep apnea 9.8 APOE ACE
40 intracranial aneurysm 9.8 APOE ACE
41 sleep disorder 9.8 APOE ACE
42 vascular dementia 9.8 APOE ACE
43 familial hyperlipidemia 9.8 APOE ACE
44 aortic aneurysm, familial abdominal, 1 9.8 APOE ACE
45 hypercholesterolemia, familial, 1 9.8 APOE ACE
46 inherited metabolic disorder 9.8 APOE ACE
47 lipid metabolism disorder 9.8 APOE ACE
48 speech and communication disorders 9.8 APOE ACE
49 atherosclerosis susceptibility 9.8 APOE ACE
50 glucose metabolism disease 9.8 APOE ACE

Graphical network of the top 20 diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to Moderate and Severe Traumatic Brain Injury

Symptoms & Phenotypes for Moderate and Severe Traumatic Brain Injury

Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

Drugs for Moderate and Severe Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4 Hemostatics Phase 4
5 Psychotropic Drugs Phase 4
6 Hypnotics and Sedatives Phase 4
7 Anesthetics Phase 4
8 GABA Modulators Phase 4
9 Anesthetics, Intravenous Phase 4
10 Anesthetics, General Phase 4
11 Anti-Anxiety Agents Phase 4
12
Tranexamic Acid Approved Phase 3 1197-18-8 5526
13 Pharmaceutical Solutions Phase 3
14 Coagulants Phase 3
15 Antifibrinolytic Agents Phase 3
16
Propranolol Approved, Investigational Phase 2 525-66-6 4946
17 Neurotransmitter Agents Phase 2
18 Anti-Arrhythmia Agents Phase 2
19 Adrenergic Antagonists Phase 2
20 Vasodilator Agents Phase 2
21 Antihypertensive Agents Phase 2
22 Adrenergic Agents Phase 2
23 Adrenergic beta-Antagonists Phase 2
24
Glucagon Approved 16941-32-5
25
Polyestradiol phosphate Approved 28014-46-2
26
Testosterone Approved, Investigational 58-22-0 6013
27
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
28 Glucagon-Like Peptide 1
29 Follicle Stimulating Hormone
30 Adrenocorticotropic Hormone
31 Hormones
32 Estradiol 17 beta-cypionate
33 Estradiol 3-benzoate
34 Melanocyte-Stimulating Hormones
35 beta-Endorphin
36 Epoetin alfa 113427-24-0
37 Hematinics

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
2 MLC901 for Moderate to Severe Traumatic Brain Injury: Pilot, Randomized, Double-Masked, Placebo-controlled Trial Recruiting NCT04487275 Phase 4 MLC901 or Placebo
3 Pre-hospital Administration of Tranexamic Acid for Adults With Moderate and Severe Traumatic Brain Injury: a Randomized, Double-blinded, Placebo-controlled Trial Unknown status NCT02645552 Phase 3 Tranexamic Acid
4 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Study Protocol for a Multicenter Randomized Open-label Trial With Blinded Adjudication of Primary Outcome Completed NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
5 Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury - (NOSTRA Phase III Trial): A Confirmatory, Placebo-controlled, Randomised, Double Blind, Multi-centre Study Completed NCT02794168 Phase 3 VAS203;Saline
6 An Exploratory Phase 2 a Study to Assess Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of VAS203 in Patients With Moderate and Severe Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
7 A Randomized, Double Blind, Placebo-Controlled Dose Escalation Study to Investigate the Safety and Pharmacokinetics After Single and Multiple Doses of SLV334 in Sequential Cohorts of Patients With Moderate and Severe Traumatic Brain Injury Terminated NCT00735085 Phase 2 SLV334;SLV334;SLV334;SLV334;Placebo
8 A Phase II, Dose Escalation, Single Center Study on the Effects of Early Propranolol on Heart Rate, Blood Pressure, and Cerebral Perfusion Pressure in Subjects Who Present With Moderate to Severe Traumatic Brain Injury. Terminated NCT01202110 Phase 2 Propranolol
9 Imaging of Glial Activation and Risk for Post-Traumatic Epilepsy Recruiting NCT03999164 Phase 1 [18F]DPA-714 Positron Emission Tomography Scan
10 Clinical Outcomes and Predictors of PITuitary Disorders in Patients With Moderate and Severe Traumatic Brain Injury: the PIT-TBI Prospective Multicenter Pilot Cohort Study Unknown status NCT02480985
11 Are Ante-hypophyseal Dysfunctions in the Acute Phase of Moderate to Severe Traumatic Brain Injury Predictive of Long-term Ante-hypophyseal Sequelae in Children? Completed NCT01250132
12 Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury Completed NCT03169647
13 Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury: A Randomised Comparison of Pressure Controlled Ventilation and Pressure Regulated Volume Controlled Ventilation Completed NCT01955785
14 A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury in Bergamo Area (Italy) Completed NCT03810222
15 A Randomized Controlled Trial of Cognitive Rehabilitation of Working Memory After Moderate to Severe Traumatic Brain Injury Recruiting NCT03874416
16 Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury Recruiting NCT03307070
17 Long Term Effects of Erythropoietin in Patients With Moderate to Severe Traumatic Brain Injury A Follow-up Study of an International Randomised Controlled Trial Recruiting NCT03061565 erythropoietin;Placebos
18 RehaCom Memory Modules in Moderate-to-severe Traumatic Brain Injury (TBI) Recruiting NCT04239456
19 Development of Persistent Fatigue Following Moderate and Severe Traumatic Brain Injury - Exploration of General and Injury-specific Mechanisms. Active, not recruiting NCT03597763
20 Brief Intervention for Substance Misuse Following Moderate or Severe Traumatic Brain Injury (TBI): A Randomized Controlled Trial Active, not recruiting NCT02129361
21 Characterization & Treatment of Chronic Pain After Moderate to Severe Traumatic Brain Injury Enrolling by invitation NCT03739307
22 Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury Enrolling by invitation NCT04530032
23 Prediction of Neurological Outcome of Children After a Moderate or Severe Traumatic Brain Injury, Based on an Integrated Predictive Model (Serum Biomarkers, Heart Rate Variability, Computerized Classifier Output) Not yet recruiting NCT04157634
24 Euthyroid Sick Syndrome (ESS)….. Can it Influence Morbidity and Mortality in Moderate to Severe Traumatic Brain Injury Patients or Correlate With Glial Fibrillary Acidic Protein (GFAP) Level. Not yet recruiting NCT04806672
25 Pilot (Feasibility) Study of New Portable Monitor for Continuous Assessment of Cerebral Blood Flow (CBF) Autoregulation in Patients With Moderate to Severe Traumatic Brain Injury (TBI) Withdrawn NCT01605838

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

Anatomical Context for Moderate and Severe Traumatic Brain Injury

MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

40
Brain, Pituitary, Temporal Lobe, Cortex

Publications for Moderate and Severe Traumatic Brain Injury

Articles related to Moderate and Severe Traumatic Brain Injury:

(show top 50) (show all 178)
# Title Authors PMID Year
1
Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury. 61
33646273 2021
2
Relationship between depression, community integration and life satisfaction following mild traumatic brain injury. 61
33780305 2021
3
Utility of Transcranial Doppler in Moderate and Severe Traumatic Brain Injury: A Narrative Review of Cerebral Physiologic Metrics. 61
33554739 2021
4
"I Couldn't Be Better": Assessing Self-Awareness With the Mayo-Portland Adaptability Inventory-4 Following TBI. 61
33782347 2021
5
Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy. 61
33498736 2021
6
Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy. 61
32814492 2021
7
Progesterone Treatment Does Not Decrease Serum Levels of Biomarkers of Glial and Neuronal Cell Injury in Moderate and Severe Traumatic Brain Injury Subjects: A Secondary Analysis of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III Trial. 61
33319651 2021
8
Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients. 61
33161840 2020
9
Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study. 61
33139989 2020
10
Treatment of posttraumatic olfactory dysfunction with corticosteroids and olfactory training. 61
32491937 2020
11
Cerebral perfusion and blood-brain barrier assessment in brain trauma using contrast-enhanced near-infrared spectroscopy with indocyanine green: A review. 61
32345103 2020
12
Objective sleep outcomes 20 years after traumatic brain injury in childhood. 61
30945574 2020
13
The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury. 61
33072197 2020
14
Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. 61
32201256 2020
15
Incidence and risk factors associated with pressure injury in patients with traumatic brain injury. 61
31994827 2020
16
[An Explorative Study about Educational Pathways after a Moderate and Severe Traumatic Brain Injury]. 61
31842238 2020
17
The Experience of Caregivers Following a Moderate to Severe Traumatic Brain Injury Requiring ICU Admission. 61
31479080 2020
18
Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. 61
31218643 2020
19
Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study. 61
32051020 2020
20
Continuous cerebrovascular reactivity monitoring in moderate/severe traumatic brain injury: a narrative review of advances in neurocritical care. 61
31983411 2020
21
Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury. 61
31702476 2020
22
Prognosis in Moderate and Severe Traumatic Brain Injury: A Systematic Review of Contemporary Models and Validation Studies. 61
31099301 2020
23
Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study. 61
31937347 2020
24
Association of cause of injury and traumatic axonal injury: a clinical MRI study of moderate and severe traumatic brain injury. 61
31604329 2019
25
The Transition Trajectory for the Patient with a Traumatic Brain Injury. 61
31331627 2019
26
Fronto-temporal vulnerability to disconnection in paediatric moderate and severe traumatic brain injury. 61
30964589 2019
27
Rehabilitation Practices in Patients With Moderate and Severe Traumatic Brain Injury. 61
30829824 2019
28
A Systematic Scoping Review of Work Interventions for Hospitalised Adults with an Acquired Neurological Impairment. 61
30515620 2019
29
Acute and Subacute Outcome Predictors in Moderate and Severe Traumatic Brain Injury: A Retrospective Monocentric Study. 61
31048051 2019
30
Pituitary pathology in traumatic brain injury: a review. 61
30927184 2019
31
Prognostic Value of Glial Fibrillary Acidic Protein in Patients With Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. 61
30889029 2019
32
Incidence and mortality of moderate and severe traumatic brain injury in children: A ten year population-based cohort study in Norway. 61
30879962 2019
33
Management of moderate and severe traumatic brain injury. 61
30980755 2019
34
Evaluation of traumatic brain injury patients with signs of alcohol intoxication. 61
31778395 2019
35
Randomized Controlled Trials of Rehabilitation Services in the Post-acute Phase of Moderate and Severe Traumatic Brain Injury - A Systematic Review. 61
31244748 2019
36
Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions. 61
29737232 2019
37
Criteria to define mild, moderate, and severe traumatic brain injury in the mouse controlled cortical impact model. 61
30017882 2018
38
Midline Shift is Unrelated to Subjective Pupillary Reactivity Assessment on Admission in Moderate and Severe Traumatic Brain Injury. 61
29619661 2018
39
Trajectory of Functional Independent Measurements during First Five Years after Moderate and Severe Traumatic Brain Injury. 61
29466920 2018
40
Usability of World Health Organization Disability Assessment Schedule in chronic traumatic brain injury. 61
29767229 2018
41
Patients with Moderate and Severe Traumatic Brain Injury: Impact of Preinjury Platelet Inhibitor or Warfarin Treatment. 61
29524716 2018
42
Diminished neural network dynamics after moderate and severe traumatic brain injury. 61
29883447 2018
43
Traumatic brain injury (TBI) outcomes in an LMIC tertiary care centre and performance of trauma scores. 61
29310574 2018
44
Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury. 61
29741969 2018
45
Modified Revised Trauma-Marshall score as a proposed tool in predicting the outcome of moderate and severe traumatic brain injury. 61
30349408 2018
46
Mortality prediction in patients with isolated moderate and severe traumatic brain injury using machine learning models. 61
30412613 2018
47
The Prognostic Value of MRI in Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. 61
29028764 2017
48
Graded Aerobic Treadmill Testing in Adolescent Traumatic Brain Injury Patients. 61
28849757 2017
49
Effect of Age on Glasgow Coma Scale in Patients with Moderate and Severe Traumatic Brain Injury: An Approach with Propensity Score-Matched Population. 61
29137197 2017
50
Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia, Is Associated with Higher Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population. 61
29099813 2017

Variations for Moderate and Severe Traumatic Brain Injury

Expression for Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for Moderate and Severe Traumatic Brain Injury

Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 APOE ACE

GO Terms for Moderate and Severe Traumatic Brain Injury

Biological processes related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 8.62 APOE ACE

Sources for Moderate and Severe Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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