MCID: MLL006
MIFTS: 24

Mollaret Meningitis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Mollaret Meningitis

MalaCards integrated aliases for Mollaret Meningitis:

Name: Mollaret Meningitis 52
Benign Multirecurrent Endothelioleukocytal Meningitis 71
Benign Recurrent Lymphocytic Meningitis 52
Benign Recurrent Aseptic Meningitis 52
Mollaret's Meningitis 52
Recurrent Meningitis 52

Classifications:



External Ids:

UMLS 71 C0220979

Summaries for Mollaret Meningitis

NIH Rare Diseases : 52 Mollaret meningitis is a type of meningitis due to a viral infection (aseptic meningitis) that occurs multiple times. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light (photophobia), and stiff neck. Some people also experience temporary neurological symptoms such as double vision, hallucinations, altered consciousness, cranial nerve palsy , or seizures . Almost half of people with Mollaret meningitis develop long-term neurological impairment such as problems with memory, balance, coordination, and/or hearing. The virus most commonly responsible for Mollaret meningitis is the herpes simplex virus (usually HSV-2, the type generally responsible for genital herpes , but also HSV-1 ). However, more than half of people with Mollaret meningitis due HSV-2 do not report a history of genital herpes. Epstein-Barr virus has also been associated with Mollaret meningitis. The diagnosis typically involves detecting herpes simplex virus DNA in the cerebrospinal fluid , which is collected during a lumbar puncture (spinal tap). This test can diagnosis other types of meningitis as well. Treatment may involve an antiviral drug such as acyclovir to treat and prevent recurrent episodes of viral meningitis, as well as various medications to treat specific symptoms present in each person. While antiviral drugs have reportedly improved symptoms in many cases, the effectiveness of antiviral therapy is difficult to measure due to the rarity of the disease and its recurrent and spontaneous nature. While aseptic meningitis usually is not fatal, serious complications such as encephalitis and coma can develop in severe cases.

MalaCards based summary : Mollaret Meningitis, also known as benign multirecurrent endothelioleukocytal meningitis, is related to mondini dysplasia and meningitis. Affiliated tissues include testes, bone and brain.

Related Diseases for Mollaret Meningitis

Diseases related to Mollaret Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 mondini dysplasia 11.6
2 meningitis 10.8
3 aseptic meningitis 10.6
4 herpes simplex 10.5
5 familial mediterranean fever 10.4
6 headache 10.3
7 epidermoid cysts 10.3
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
9 branchiootic syndrome 1 10.2
10 meningocele 10.2
11 pfeiffer syndrome 10.1
12 ocular motor apraxia 10.1
13 leukemia, acute lymphoblastic 10.1
14 lymphoma 10.1
15 lymphocytic leukemia 10.1
16 meningoencephalitis 10.1
17 collagen disease 10.1
18 subacute delirium 10.1
19 cerebrospinal fluid leak 10.1
20 epidermoid brain cyst 10.1
21 encephalocele 10.1
22 meningoencephalocele 10.1
23 systemic lupus erythematosus 10.1
24 aphasia 10.1
25 chronic meningitis 10.1
26 vasculitis 10.1
27 genital herpes 10.1
28 lupus erythematosus 10.1
29 bacterial meningitis 10.1
30 toxoplasmosis 10.1
31 back pain 10.1
32 neurenteric cyst 10.1
33 ear malformation 10.0
34 sensorineural hearing loss 10.0
35 otitis media 10.0
36 head injury 10.0
37 deafness, unilateral 9.9
38 perilymphatic fistula 9.9
39 viral meningitis 9.9
40 neural tube defects 9.9
41 hemangiopericytoma, malignant 9.9
42 meningioma, radiation-induced 9.9
43 meningioma, familial 9.9
44 spinal meningioma 9.9
45 secretory meningioma 9.9
46 lymphoplasmacyte-rich meningioma 9.9
47 complement deficiency 9.9
48 haemophilus influenzae 9.9
49 pneumococcal meningitis 9.9
50 autoimmune disease 9.8

Graphical network of the top 20 diseases related to Mollaret Meningitis:



Diseases related to Mollaret Meningitis

Symptoms & Phenotypes for Mollaret Meningitis

Drugs & Therapeutics for Mollaret Meningitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Familial Nonsyndromal Mondini Dysplasia Completed NCT00004336
2 A New Cochlear Implant Electrode With A "Cork" Type Stopper For Inner Ear Malformations Completed NCT02011867
3 Evaluation of Different Methods for Rapid Diagnosis of Meningitis in Assiut University Hospital Not yet recruiting NCT03759470

Search NIH Clinical Center for Mollaret Meningitis

Genetic Tests for Mollaret Meningitis

Anatomical Context for Mollaret Meningitis

MalaCards organs/tissues related to Mollaret Meningitis:

40
Testes, Bone, Brain, Pituitary, Bone Marrow, Skin, Tonsil

Publications for Mollaret Meningitis

Articles related to Mollaret Meningitis:

(show top 50) (show all 551)
# Title Authors PMID Year
1
Recurrent Meningitis. 61 52
28551737 2017
2
Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis. 61
31830942 2019
3
Recurrent meningitis associated to Strongyloides hyperinfection. 61
30772102 2019
4
Cochlear Implantation in a Child With Recurrent Meningitis Due to a Congenital Stapedial Footplate Defect. 61
31578108 2019
5
Recurrence of group B streptococcal meningitis. 61
31506230 2019
6
Management of Gorham Stout disease with skull-base defects: Case series of six children and literature review. 61
31195309 2019
7
Simultaneous repair of cerebrospinal fluid otorrhea and cochlear implantation in two patients with recurrent meningitis and severe inner ear malformation. 61
31195308 2019
8
In Patients with Unexplained Non-Epidemic Recurrent Meningitis a Direct Communication between the Subarachnoid Space and the Outside Must Be Sough. 61
31257190 2019
9
Recurrent meningitis by Streptococcus pneumoniae in a girl with cochlear implant and head trauma despite 13-valent conjugated pneumococcal vaccine. 61
31339278 2019
10
Delay Posttraumatic Paradoxical Cerebrospinal Fluid Leak with Recurrent Meningitis. 61
31497141 2019
11
Community-Acquired Bacterial Meningitis In Adults With Cerebrospinal Fluid Leakage. 61
31300817 2019
12
Dorsal dermal sinus presenting as quadriparesis. 61
31256046 2019
13
Vertebral artery dissection associated with familial Mediterranean fever and Behçet's disease. 61
31139696 2019
14
Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin. 61
30568139 2019
15
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue. 61
30897548 2019
16
Intracranial endodermal cyst presenting with nonobstructive hydrocephalus: A case report. 61
30732152 2019
17
Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma. 61
30747288 2019
18
Mollaret meningitis. 61
30471634 2019
19
Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach. 61
30541535 2018
20
Secondary pituitary abscess following transsphenoidal surgery with recurrent meningitis: A case report. 61
30508969 2018
21
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. 61
29366968 2018
22
Recurrent Meningitis in an 11-year-old Girl with a Petrous Apex Cystic Lesion. 61
30369610 2018
23
Recurrent aseptic meningitis with PIGT mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab. 61
30262533 2018
24
Endoscopic removal of a suprasellar dermoid cyst in a pediatric patient: a case report and review of the literature. 61
29557987 2018
25
Recurrent meningitis in children: etiologies, outcome, and lessons to learn. 61
29728757 2018
26
Salmonella typhimurium Meningitis in an Infant Presenting with Recurrent Meningitis. 61
29238942 2018
27
Recurrent meningitis caused by idiopathic cerebrospinal fluid rhinorrhoea from the sphenoid sinus. 61
29895541 2018
28
Outcome of uncorrected CSF leak and consequent recurrent meningitis in a patient: a case presentation and literature review. 61
29807467 2018
29
Meningoencephalocele causing recurrent meningitis. 61
29744093 2018
30
[Expert consensus on the diagnosis and treatment of cryptococcal meningitis]. 61
29747285 2018
31
Recurrent meningitis after cysto-sphenoidostomy surgery for craniopharyngioma healed with removal of the implanted catheter. 61
29480686 2018
32
Adult Patients with Pneumococcal Meningitis at a Neurosurgical Neurologic Center: Different Predisposing Conditions? 61
29170119 2018
33
A Perplexing Case of Pituitary Apoplexy Masquerading as Recurrent Meningitis. 61
30480002 2018
34
Erratum: Utility of magnetic resonance cisternography with intrathecal gadolinium in detection of cerebrospinal fluid fistula associated with Mondini dysplasia in a patient with recurrent meningitis: Case report and literature review. 61
30009082 2018
35
Utility of magnetic resonance cisternography with intrathecal gadolinium in detection of cerebrospinal fluid fistula associated with Mondini dysplasia in a patient with recurrent meningitis: Case report and literature review. 61
29770252 2018
36
Congenital Fistulae of the Stapedial Footplate and Round Window Membrane: An Unusual Cause of Recurrent Meningitis. 61
29145546 2017
37
Metastatic clival chordoma: a case report of multiple extraneural metastases following resection and proton beam radiotherapy in a 5-year old boy. 61
28304223 2017
38
Diagnostic Dilemma in a 15-Year-Old Boy with Recurrent Pneumococcal Meningitis. 61
28658867 2017
39
Acute recurrent lymphocytic meningitis in an immunocompetent HIV-positive African woman: Is it a Mollaret's meningitis or not? 61
28835824 2017
40
Transsphenoidal meningoencephalocele protruding into the nasal cavity. 61
30363286 2017
41
Recurrent meningitis with unusually delayed cerebrospinal fluid leak detected by magnetic resonance cisternography. 61
28084280 2017
42
Transalar transsphenoidal meningoencephalocele presenting in the form of recurrent meningitis: Report of two cases and discussion of the diagnosis and treatment. 61
27431342 2016
43
Herpes simplex virus type 2-associated recurrent aseptic meningitis (Mollaret's meningitis) with a recurrence after 11-year interval: a case report. 61
27773908 2016
44
Ventral foramen magnum neurenteric cysts: a case series and review of literature. 61
26662045 2016
45
Common variable immunodeficiency, immune thrombocytopenia, rituximab and splenectomy: important considerations. 61
27276370 2016
46
Long-term outcomes of a transmastoid lateral semicircular canal approach to congenital CSF otorrhea in children associated with recurrent meningitis and severe inner ear malformation. 61
27368469 2016
47
Use of Intrathecal Fluorescein in Recurrent Meningitis after Cochlear Implantation. 61
27429952 2016
48
[Pediatric Patient with anaerobic Bacterial Meningitis Who was Infected through a Spinal Congenital Dermal Sinus Route]. 61
27529968 2016
49
Transcanal Endoscopic Management of Cerebrospinal Fluid Otorrhea Secondary to Congenital Inner Ear Malformations. 61
26571412 2016
50
[Recurrent meningitis and inherited complement deficiency]. 61
28078901 2016

Variations for Mollaret Meningitis

Expression for Mollaret Meningitis

Search GEO for disease gene expression data for Mollaret Meningitis.

Pathways for Mollaret Meningitis

GO Terms for Mollaret Meningitis

Sources for Mollaret Meningitis

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72 UMLS via Orphanet
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