MCID: MLL001
MIFTS: 48

Molluscum Contagiosum

Categories: Infectious diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Molluscum Contagiosum

MalaCards integrated aliases for Molluscum Contagiosum:

Name: Molluscum Contagiosum 12 73 54 3 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8867
ICD9CM 34 078.0
MeSH 44 D008976
NCIt 50 C155872
SNOMED-CT 67 154360009
ICD10 32 B08.1
UMLS 70 C0026393

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years. The lesions, known as Mollusca, are small, raised, and usually white, pink, or flesh-colored with a dimple or pit in the center. They often have a pearly appearance. They're usually smooth and firm. In most people, the lesions range from about the size of a pinhead to as large as a pencil eraser (2 to 5 millimeters in diameter). They may become itchy, sore, red, and/or swollen. Mollusca may occur anywhere on the body including the face, neck, arms, legs, abdomen, and genital area, alone or in groups. The lesions are rarely found on the palms of the hands or the soles of the feet.

MalaCards based summary : Molluscum Contagiosum is related to anogenital venereal wart and clear cell acanthoma, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is CASP8 (Caspase 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cantharidin and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 73 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results... more...

Related Diseases for Molluscum Contagiosum

Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 anogenital venereal wart 30.5 TLR9 RB1 IFNB1
2 clear cell acanthoma 30.2 IVL FLG
3 human immunodeficiency virus type 1 29.8 TNF CXCL12 CCL27 CASP8
4 keratosis 29.7 LORICRIN IVL FLG
5 skin disease 29.6 TNF LORICRIN IVL FLG CCL27 CASP8
6 immune deficiency disease 29.6 TNF TLR9 IKBKG IFNB1 CXCL12 CCR8
7 dermatitis, atopic 29.6 TNF TLR9 LORICRIN IVL FLG CCL27
8 lichen planus 29.5 TNF IVL FLG
9 dermatitis 29.2 TNF TLR9 LORICRIN IVL FLG CCL27
10 psoriasis 28.9 TNF TLR9 LORICRIN IVL FLG CCL27
11 skin carcinoma 27.9 TNF TLR9 LORICRIN IVL IFNB1 FLG
12 hyper ige syndrome 11.3
13 immunodeficiency 58 11.2
14 hyper-ige recurrent infection syndrome 2, autosomal recessive 11.2
15 b-cell expansion with nfkb and t-cell anergy 11.2
16 acquired immunodeficiency syndrome 10.8
17 vaccinia 10.7
18 conjunctivitis 10.6
19 cryptococcosis 10.5
20 smallpox 10.5
21 leprosy 3 10.5
22 herpes simplex 10.5
23 hansen's disease 10.5
24 epidermoid cysts 10.5
25 squamous cell papilloma 10.5
26 papilloma 10.5
27 pustulosis of palm and sole 10.4
28 kaposi sarcoma 10.4
29 dowling-degos disease 1 10.4
30 variola major 10.4
31 keratitis, hereditary 10.4
32 langerhans cell histiocytosis 10.4
33 exanthem 10.4
34 basal cell carcinoma 10.4
35 histiocytosis 10.4
36 herpes zoster 10.4
37 keratoconjunctivitis 10.4
38 neuroretinitis 10.3
39 lepromatous leprosy 10.3
40 histoplasmosis 10.3
41 retinitis 10.3
42 lymphopenia 10.3
43 scabies 10.3
44 epidermodysplasia verruciformis 1 10.2
45 human herpesvirus 8 10.2
46 cytomegalovirus retinitis 10.2
47 mumps 10.2
48 keratoacanthoma 10.2
49 cellulitis 10.2
50 measles 10.2

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

MGI Mouse Phenotypes related to Molluscum Contagiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CARMIL2 CASP8 CUL5 CXCL12 FADD IFNB1
2 immune system MP:0005387 9.8 CARMIL2 CASP8 CCR8 CUL5 CXCL12 FADD
3 liver/biliary system MP:0005370 9.23 CASP8 CXCL12 FADD IKBKG IL18BP RB1

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3 56-25-7
2
tannic acid Approved 1401-55-4
3
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
4
Acyclovir Approved 59277-89-3 2022
5
Ethanol Approved 64-17-5 702
6 Dermatologic Agents
7 Pharmaceutical Solutions
8 Omega 3 Fatty Acid Early Phase 1
9 Anti-Infective Agents
10 Antiviral Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Phase 3 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study Comparing the Efficacy and Safety of SB206 and Vehicle Gel Once Daily in the Treatment of Molluscum Contagiosum Completed NCT03927716 Phase 3 SB206 12%;Placebo
2 A Phase 3 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study Comparing the Efficacy and Safety of SB206 and Vehicle Gel Once Daily in the Treatment of Molluscum Contagiosum Completed NCT03927703 Phase 3 SB206 12%;Placebo
3 Efficacy and Tolerance of the Topical Application of Potassium Hydroxide (10% and 15%) in the Treatment of Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
4 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377803 Phase 3 VP-102;Placebo
5 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377790 Phase 3 VP-102;Placebo
6 A Phase 3 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study Comparing the Efficacy and Safety of SB206 and Vehicle Gel Once Daily in the Treatment of Molluscum Contagiosum Active, not recruiting NCT04535531 Phase 3 SB206 10.3% berdazimer;vehicle gel
7 A Phase 2, Open-Label Study to Evaluate the Safety, Efficacy and Systemic Exposure of VP-102 Topical Film Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03186378 Phase 2
8 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
9 A Multicenter, Randomized, Double-Blind, Vehicle-Controlled Phase II Study to Evaluate the Efficacy, Tolerability, and Safety of VBP-245 in Pediatric Subjects for the Treatment of Molluscum Contagiosum Completed NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
10 Randomized Pilot Study Investigating the Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
11 A Phase 2 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled Ascending Dose Study of SB206 in Subjects With Molluscum Contagiosum Completed NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
12 A Multi-center, Double-blind, Placebo-controlled, Randomized Safety and Efficacy Trial of a Botanical Drug Product Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum in Pediatric Subjects Terminated NCT02024581 Phase 2 10% East Indian sandalwood oil cream;Placebo Cream
13 Picato for the Treatment of Molluscum Contagiosum in Immunocompromised Patients Unknown status NCT03336372 Early Phase 1 Picato
14 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822
15 Efficacy of Cantharidin in Molluscum Contagiosum: A Randomized, Blinded, Placebo-Controlled Prospective Study Completed NCT00667225 cantharidin's vehicle;Cantharidin 0.7%
16 Pro-Resolving Mediators in Acute Inflammation in Humans Recruiting NCT04308889 Early Phase 1 Lovaza
17 The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children Recruiting NCT04476186 Acyclovir;KOH 10 %
18 Using a Cold Atmospheric Plasma Device to Treat Skin Disorders Recruiting NCT02759900

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Cantharidin

Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

19
Skin

MalaCards organs/tissues related to Molluscum Contagiosum:

40
Skin, Eye, Cervix, Myeloid, Bone Marrow, Lymph Node, Nk Cells

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 1666)
# Title Authors PMID Year
1
Molluscum contagiosum prevents progression of staphylococcal scalded skin syndrome. 54 61
16091916 2005
2
Lamellarins, from A to Z: a family of anticancer marine pyrrole alkaloids. 61 54
15281908 2004
3
Interleukin-18 and glycosaminoglycan binding by a protein encoded by Variola virus. 54 61
15105546 2004
4
Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. 61 54
12552001 2003
5
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. 61 54
11752160 2002
6
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. 61 54
11493620 2001
7
A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. 61 54
10620615 2000
8
An immunohistochemical study of abnormal keratinocyte differentiation in molluscum contagiosum. 54 61
10417525 1999
9
Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining. 61 54
10228630 1999
10
Mask-induced Koebner phenomenon and its clinical phenotypes: A multicenter, real-life study focusing on 873 dermatological consultations during COVID-19 pandemics. 61
33527560 2021
11
Recalcitrant molluscum contagiosum successfully treated with intralesional cidofovir in a patient with HIV/AIDS. 61
32966594 2021
12
High-risk sexual behavior and HIV/STDs cascade of care in migrants: results from an Italian dedicated outpatient clinic. 61
33690214 2021
13
Pooled Results of Two Randomized Phase III Trials Evaluating VP-102, a Drug-Device Combination Product Containing Cantharidin 0.7% (w/v) for the Treatment of Molluscum Contagiosum. 61
33599960 2021
14
The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis. 61
33667150 2021
15
Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus. 61
31922947 2021
16
JAAD Game Changers∗: Cantharidin for treatment of facial molluscum contagiosum: A retrospective review. 61
33640511 2021
17
Unethical use of imiquimod as a comparator group in a randomized clinical trial of children with molluscum contagiosum. 61
33058946 2021
18
Extensive Molluscum Contagiosum in X-Linked Agammaglobulinemia. 61
32811796 2021
19
5-Fluorouracil in Dermatology: The Diverse Uses Beyond Malignant and Premalignant Skin Disease. 61
33587385 2021
20
Intralesional measles, mumps, and rubella vaccine immunotherapy in molluscum contagiosum: A retrospective observational study from a tertiary care center in north India. 61
33283407 2021
21
[Recurrent vulvar rashes in a girl aged 22 months for more than half a year]. 61
33476545 2021
22
An Efficacy of Cantharidin Treatment in Facial Molluscum Contagiosum in Younger Children: A Prospective Interventional Study in 67 Children. 61
33340535 2021
23
Antimicrobial photodynamic therapy in the treatment of giant molluscum contagiosum: A case report and review of the literature. 61
33277812 2021
24
2020 European guideline on the management of genital molluscum contagiosum. 61
32881110 2021
25
A Phase 2 Open-Label Study to Evaluate VP-102 for the Treatment of Molluscum Contagiosum. 61
33400412 2021
26
Characterization of a Complete Genome Sequence of Molluscum Contagiosum Virus from an Adult Woman in Australia. 61
33414285 2021
27
Rosettes in T-cell pseudolymphoma: a new dermoscopic finding. 61
33288369 2021
28
Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam. 61
33350920 2021
29
A comparative study of topical cantharidin and intralesional PPD to treat molluscum contagiosum. 61
31418621 2020
30
Infectious diseases of the skin in contact sports. 61
33389840 2020
31
Atypical presentation of genital molluscum contagiosum mimicking genital warts. 61
32438855 2020
32
Safety and Efficacy of VP-102, a Proprietary, Drug-Device Combination Product Containing Cantharidin, 0.7% (w/v), in Children and Adults With Molluscum Contagiosum: Two Phase 3 Randomized Clinical Trials. 61
32965495 2020
33
Topical cidofovir for the treatment of recalcitrant viral warts and molluscum contagiosum in Jacobsen syndrome. 61
32897593 2020
34
Intralesional immunotherapy for molluscum contagiosum: A review. 61
33044025 2020
35
Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID-19 pandemic. 61
32614116 2020
36
Cantharidin Drug-Device Clears Molluscum Contagiosum Lesions. 61
33231658 2020
37
Oral echinacea for prevention of relapses of molluscum contagiosum. 61
33016668 2020
38
Extensive palpebral molluscum contagiosum in an immunocompetent child. 61
33380713 2020
39
Abnormal cutaneous reaction to potassium hydroxide in molluscum contagiosum in children: an observational study on 8 patients. 61
33070569 2020
40
Eyelid and Orbital Involvement in HIV Infection - An African Perspective. 61
32058857 2020
41
Ruxolitinib-Associated Infections in Polycythemia Vera: Review of the Literature, Clinical Significance, and Recommendations. 61
33114733 2020
42
Dupilumab may facilitate the clearance of molluscum contagiosum in atopic dermatitis patients. 61
32881369 2020
43
A practical review of dermoscopy for pediatric dermatology part II: Vascular tumors, infections, and inflammatory dermatoses. 61
32749020 2020
44
Epidermolytic acanthoma: A case report. 61
33024766 2020
45
Molluscum Contagiosum on the Sole of the Foot in an Elderly Patient: A Case Report. 61
32941406 2020
46
An atypical presentation of discrete papular mucinosis in the genitalia mimicking a molluscum contagiosum infection. 61
33054946 2020
47
BOTE sign in molluscum contagiosum. 61
32938659 2020
48
Molluscum contagiosum among Greek young competitive swimmers. 61
32597622 2020
49
Dupilumab kann die Abheilung von Molluscum contagiosum bei Patienten mit atopischer Dermatitis erleichtern. 61
32985825 2020
50
The Molluscum Contagiosum Gene MC021L Partially Compensates for the Loss of Its Vaccinia Virus Homolog, F13L. 61
32727873 2020

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF TLR9 RELA IL18BP IKBKG IFNB1
2
Show member pathways
13.4 TNF TLR9 IKBKG FADD CXCL12 CCR8
3
Show member pathways
13.14 TNF TLR9 RELA RB1 IKBKG IFNB1
4
Show member pathways
13.07 TNF RELA RB1 IKBKG FADD CASP8
5
Show member pathways
12.95 TNF RELA RB1 IKBKG IFNB1 FADD
6
Show member pathways
12.87 RELA IKBKG CXCL12 CCR8 CCL27
7 12.74 TNF TLR9 RELA IKBKG IFNB1 FADD
8
Show member pathways
12.73 TNF TLR9 RELA IKBKG FADD CASP8
9
Show member pathways
12.71 TNF TLR9 RELA IL18BP IKBKG IFNB1
10
Show member pathways
12.7 TNF RELA IKBKG FADD CASP8
11
Show member pathways
12.67 TNF TLR9 RELA IKBKG FADD CXCL12
12 12.65 RELA RB1 IKBKG FADD ELOC ELOB
13
Show member pathways
12.58 TNF TLR9 IKBKG FADD CASP8
14 12.56 TNF TLR9 RELA IKBKG CXCL12
15
Show member pathways
12.47 TNF TLR9 RELA RB1 IKBKG IFNB1
16 12.39 TNF RELA IKBKG IFNB1
17 12.33 TNF RELA RB1 IKBKG
18
Show member pathways
12.32 TNF CXCL12 CCR8 CCL27
19
Show member pathways
12.32 TNF RELA IKBKG FADD CASP8
20
Show member pathways
12.31 TNF RELA IKBKG FADD CASP8
21
Show member pathways
12.3 TNF RELA IKBKG IFNB1 FADD CXCL12
22 12.27 RELA RB1 IKBKG CCR8 CASP8
23
Show member pathways
12.26 TNF RELA IKBKG CASP8
24
Show member pathways
12.21 TNF TLR9 RELA IKBKG IFNB1
25
Show member pathways
12.2 TNF IFNB1 FADD CASP8
26
Show member pathways
12.2 TNF RB1 FADD CASP8
27
Show member pathways
12.2 TNF RELA RB1 IKBKG IFNB1 FADD
28 12.17 TNF RELA IKBKG IFNB1 FADD CASP8
29
Show member pathways
12.16 TNF TLR9 RELA IKBKG CASP8
30 12.14 TNF TLR9 RELA IFNB1 FADD CASP8
31
Show member pathways
12.13 TNF TLR9 RELA IKBKG IFNB1
32 12.08 TNF RELA IKBKG IFNB1
33 12.04 TNF RELA IKBKG IFNB1
34
Show member pathways
12.02 TLR9 RELA IKBKG CASP8
35 11.94 TNF RELA IKBKG CXCL12
36 11.85 RELA RB1 IKBKG
37
Show member pathways
11.8 RELA IKBKG CXCL12
38 11.75 TNF TLR9 IFNB1
39
Show member pathways
11.74 TNF RELA IKBKG
40 11.7 TNF RELA IKBKG
41 11.61 TNF RELA CASP8
42 11.58 TNF RELA IKBKG
43
Show member pathways
11.55 TNF RELA IKBKG
44 11.52 TNF RELA RB1
45 11.51 IFNB1 FADD CASP8
46 11.48 TNF RELA IKBKG IFNB1 FADD CASP8
47 11.44 RELA IKBKG CASP8
48 11.4 TNF RELA FADD CASP8
49 11.29 TNF RELA IKBKG
50 11.15 TNF RELA IKBKG

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Cul2-RING ubiquitin ligase complex GO:0031462 9.43 ELOC ELOB
2 elongin complex GO:0070449 9.4 ELOC ELOB
3 death-inducing signaling complex GO:0031264 9.37 FADD CASP8
4 ripoptosome GO:0097342 9.32 FADD CASP8
5 Cul5-RING ubiquitin ligase complex GO:0031466 9.26 ELOB CUL5
6 CD95 death-inducing signaling complex GO:0031265 9.16 FADD CASP8
7 VCB complex GO:0030891 8.96 ELOC ELOB
8 cornified envelope GO:0001533 8.8 LORICRIN IVL FLG

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 TNF TLR9 RELA RB1 IKBKG IFNB1
2 immune response GO:0006955 9.93 TNF TLR9 IKBKG CXCL12 CCR8 CCL27
3 defense response to virus GO:0051607 9.91 TLR9 RELA IFNB1 FADD
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TNF TLR9 RELA IKBKG
5 defense response GO:0006952 9.84 TNF RELA IFNB1 CXCL12
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.82 TNF FADD CASP8
7 cell chemotaxis GO:0060326 9.82 CXCL12 CCR8 CCL27
8 apoptotic signaling pathway GO:0097190 9.81 TNF FADD CASP8
9 response to virus GO:0009615 9.81 TNF IKBKG IFNB1 CXCL12
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 TNF TLR9 RELA
11 positive regulation of interferon-gamma production GO:0032729 9.77 TNF TLR9 FADD
12 keratinocyte differentiation GO:0030216 9.75 LORICRIN IVL FLG
13 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF FADD CASP8
14 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.67 IKBKG FADD CASP8
15 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.67 TNF TLR9 RELA IKBKG
16 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.65 TNF RELA
17 activation of cysteine-type endopeptidase activity GO:0097202 9.65 FADD CASP8
18 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.65 TNF FADD CASP8
19 toll-like receptor 3 signaling pathway GO:0034138 9.64 FADD CASP8
20 cellular response to nicotine GO:0071316 9.63 TNF RELA
21 response to UV-B GO:0010224 9.62 RELA IVL
22 necroptotic signaling pathway GO:0097527 9.61 TNF FADD
23 peptide cross-linking GO:0018149 9.61 LORICRIN IVL FLG
24 regulation of necroptotic process GO:0060544 9.58 FADD CASP8
25 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.58 TNF IKBKG CASP8
26 positive regulation of mononuclear cell migration GO:0071677 9.57 TNF CCL27
27 TRAIL-activated apoptotic signaling pathway GO:0036462 9.56 FADD CASP8
28 positive regulation of interleukin-8 production GO:0032757 9.56 TNF TLR9 RELA FADD
29 positive regulation of macrophage differentiation GO:0045651 9.5 RB1 FADD CASP8
30 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.43 TNF TLR9 RELA IKBKG FADD CASP8
31 death-inducing signaling complex assembly GO:0071550 9.33 TNF FADD CASP8
32 viral process GO:0016032 9.28 RELA RB1 IKBKG FADD ELOC ELOB

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 TNF IFNB1 CXCL12 CCL27
2 protein-containing complex binding GO:0044877 9.43 RELA IKBKG FADD ELOC CASP8 CARMIL2
3 death receptor binding GO:0005123 9.4 FADD CASP8
4 structural constituent of epidermis GO:0030280 9.37 LORICRIN FLG
5 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FADD CASP8
6 death effector domain binding GO:0035877 9.26 FADD CASP8
7 ubiquitin protein ligase binding GO:0031625 9.1 RELA RB1 IKBKG ELOB CUL5 CASP8

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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