MCID: MLL001
MIFTS: 51

Molluscum Contagiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Molluscum Contagiosum

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.

MalaCards based summary : Molluscum Contagiosum is related to hyper-ige recurrent infection syndrome, autosomal recessive and b-cell expansion with nfkb and t-cell anergy, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is CASP8 (Caspase 8), and among its related pathways/superpathways are fMLP Pathway and Toll-like Receptor Signaling Pathway. The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 76 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results... more...

Related Diseases for Molluscum Contagiosum

Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 hyper-ige recurrent infection syndrome, autosomal recessive 11.4
2 b-cell expansion with nfkb and t-cell anergy 11.4
3 immunodeficiency 58 11.4
4 dermatitis 10.6
5 dermatitis, atopic 10.6
6 acquired immunodeficiency syndrome 10.6
7 cryptococcosis 10.5
8 viral infectious disease 10.5
9 human immunodeficiency virus infectious disease 10.5
10 herpes simplex 10.5
11 epidermoid cysts 10.5
12 vaccinia 10.4
13 psoriasis 10.4
14 langerhans cell histiocytosis 10.3
15 lymphoma 10.3
16 lepromatous leprosy 10.3
17 anogenital venereal wart 10.3
18 histiocytosis 10.3
19 conjunctivitis 10.3
20 epidermodysplasia verruciformis 10.3
21 basal cell carcinoma 1 10.3
22 basal cell carcinoma 10.3
23 papilloma 10.3
24 cellulitis 10.3
25 herpes zoster 10.3
26 hyper ige syndrome 10.3
27 cutaneous pseudolymphoma 10.3
28 erythema multiforme 10.2
29 methemoglobinemia 10.2
30 sarcoma 10.2
31 histoplasmosis 10.2
32 squamous cell carcinoma 10.2
33 folliculitis 10.2
34 scabies 10.2
35 post-transplant lymphoproliferative disease 10.1 CASP8 FADD
36 kaposi sarcoma 10.0
37 retinoblastoma 10.0
38 rheumatoid arthritis 10.0
39 focal epithelial hyperplasia, oral 10.0
40 mycosis fungoides 10.0
41 myeloma, multiple 10.0
42 wiskott-aldrich syndrome 10.0
43 asthma 10.0
44 human immunodeficiency virus type 1 10.0
45 leukemia, acute lymphoblastic 10.0
46 arthritis 10.0
47 b-cell lymphomas 10.0
48 crohn's disease 10.0
49 granuloma annulare 10.0
50 hepatitis 10.0

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

GenomeRNAi Phenotypes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CASP8 CUL5 FADD IKBKG RB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CASP8 CUL5 FADD IKBKG RB1
3 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 9.26 CUL5 CXCL12 FADD LOR

MGI Mouse Phenotypes related to Molluscum Contagiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 CARMIL2 CASP8 FADD IKBKG RB1 RELA
2 hematopoietic system MP:0005397 9.8 CARMIL2 CASP8 CXCL12 FADD IKBKG RB1
3 immune system MP:0005387 9.76 CARMIL2 CASP8 CUL5 CXCL12 FADD IKBKG
4 liver/biliary system MP:0005370 9.43 CASP8 CXCL12 FADD IKBKG RB1 RELA
5 muscle MP:0005369 9.02 CASP8 CXCL12 FADD RB1 RELA

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3,Phase 2,Not Applicable 56-25-7
2 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3
3 tannic acid Approved Not Applicable
4
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
5 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
2 Cantharidin Application in Molluscum Patients Active, not recruiting NCT03377803 Phase 3 VP-102;Placebo
3 Cantharidin Application in Molluscum Patients-1 Active, not recruiting NCT03377790 Phase 3 VP-102;Placebo
4 Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum. Completed NCT03186378 Phase 2 VP-102
5 A Study to Evaluate the Safety and Efficacy of SB206 in Subjects With Molluscum Contagiosum Completed NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
6 A Study of VBP-245 in Pediatric Patients With Molluscum Contagiosum Completed NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
7 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
8 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
9 A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum Terminated NCT02024581 Phase 2 10% East Indian sandalwood oil cream;Placebo Cream
10 Efficacy of Cantharidin in Molluscum Contagiosum Completed NCT00667225 Not Applicable cantharidin's vehicle;Cantharidin 0.7%
11 Picato for the Treatment of Molluscum Contagiosum in Immunocompromised Patients Recruiting NCT03336372 Early Phase 1 Picato
12 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

19
Skin

MalaCards organs/tissues related to Molluscum Contagiosum:

41
Skin, Bone, T Cells, Cervix, Eye, Bone Marrow, B Cells

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 917)
# Title Authors Year
1
Comment on "Molluscum contagiosum: Review and update on management". ( 29575072 )
2018
2
Langerhans cell histiocytosis mimicking molluscum contagiosum: A case series. ( 29528195 )
2018
3
Efficacy and safety of topical application of 15% and 10% potassium hydroxide for the treatment of Molluscum contagiosum. ( 29479727 )
2018
4
Update on the Treatment of molluscum Contagiosum in children. ( 29576186 )
2018
5
Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency. ( 29282454 )
2018
6
Molluscum contagiosum arising in a melanocytic congenital nevus. ( 29971818 )
2018
7
Efficacy of combination therapies of topical 5% imiquimod and liquid nitrogen for penile molluscum contagiosum. ( 29667708 )
2018
8
Treatment of molluscum contagiosum with hydrogen peroxide. ( 29058324 )
2018
9
Cantharidin for treatment of facial molluscum contagiosum: A retrospective review. ( 29241785 )
2018
10
Image Gallery: Molluscum contagiosum-like facial lesions in a patient with a renal transplant: deep dermatophytosis due to Trichophyton rubrum. ( 29785830 )
2018
11
An unusual presentation of giant molluscum contagiosum diagnosed on cytology. ( 29736921 )
2018
12
Expression of YAP and TAZ in molluscum contagiosum virus infected skin. ( 29330849 )
2018
13
Oral Echinacea exerts complete clearing of multiple facial molluscum contagiosum in a young black patient. ( 29582619 )
2018
14
Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. ( 29904968 )
2018
15
Imiquimod cream for molluscum contagiosum: Neither safe nor effective. ( 29575068 )
2018
16
Use of a disposable ear speculum: An alternative technique for molluscum contagiosum curettage. ( 29575222 )
2018
17
Complete resolution of facial molluscum contagiosum in a HIV-infected patient by antiretroviral therapy. ( 28971509 )
2018
18
Expanding the Morphologic Heterogeneity of Stromal Changes in Molluscum Contagiosum Infection. ( 29329128 )
2018
19
A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. ( 29393023 )
2018
20
Periocular molluscum contagiosum: six different clinical presentations. ( 29855150 )
2018
21
Autoinoculation as a treatment modality for molluscum contagiosum: A preliminary uncontrolled trial. ( 29251278 )
2018
22
Molluscum contagiosum in immunocompromised patients: AIDS presenting as molluscum contagiosum in a patient with psoriasis on biologic therapy. ( 29554156 )
2018
23
Molluscum contagiosum virus infection can trigger atopic dermatitis disease onset or flare. ( 30372710 )
2018
24
Treatment of molluscum contagiosum with an East Indian sandalwood oil product. ( 29103323 )
2018
25
An unusual reaction to molluscum contagiosum. ( 29319288 )
2018
26
Intralesional 5-fluorouracil to treat extensive molluscum contagiosum in an immunocompromised patient: A novel therapeutic modality. ( 30019365 )
2018
27
Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. ( 30097988 )
2018
28
Presence of molluscum contagiosum virus within an epidermal cyst. ( 30130000 )
2018
29
Reviewing the use of imiquimod for molluscum contagiosum. ( 30142710 )
2018
30
Glycolic acid cream for treatment of molluscum contagiosum. ( 30155957 )
2018
31
Molluscum-contagiosum-Virus in einer Epidermalzyste. ( 30179331 )
2018
32
New Insights into the Evolutionary and Genomic Landscape of Molluscum Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome Sequences. ( 30373153 )
2018
33
Clinical, Histopathological, and Virological Evaluation of 203 Patients With a Clinical Diagnosis of Molluscum Contagiosum. ( 30539041 )
2018
34
Pulsed Dye Laser Repurposed: Treatment of Refractory Molluscum Contagiosum in Renal Transplant Patient. ( 30548559 )
2018
35
Molluscum contagiosum: an update. ( 28521677 )
2017
36
Melan A Antibody Cross-Reactivity in Molluscum Contagiosum Bodies. ( 28805130 )
2017
37
Molluscum Contagiosum in a Patient with Atopic Dermatitis. ( 29166239 )
2017
38
Molluscum Contagiosum of the Gluteal Cleft: Observations and Implications for Management in Five Children. ( 28543922 )
2017
39
The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions. ( 28425034 )
2017
40
Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2. ( 28555548 )
2017
41
Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children. ( 28871935 )
2017
42
Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis. ( 28866311 )
2017
43
Desmoplastic trichilemmoma dermoscopically mimicking molluscum contagiosum. ( 28087019 )
2017
44
A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. ( 28670845 )
2017
45
Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015 ( 28806866 )
2017
46
Molluscum contagiosum and pubic hair removal in male patients. ( 29027896 )
2017
47
Molluscum Contagiosum: A Rare Nipple Lesion. ( 27670745 )
2017
48
Molluscum Contagiosum ( 28722927 )
2017
49
Disseminated molluscum contagiosum lesions in an HIV patient. ( 28322681 )
2017
50
Limited treatment options for molluscum contagiosum. ( 28768690 )
2017

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 CASP8 CXCL12 IKBKG RELA
2
Show member pathways
12.83 CASP8 FADD IKBKG RELA
3
Show member pathways
12.76 CASP8 FADD IKBKG RB1 RELA
4
Show member pathways
12.76 CASP8 FADD IKBKG RB1 RELA
5
Show member pathways
12.75 CASP8 CXCL12 FADD IKBKG
6
Show member pathways
12.65 CASP8 CXCL12 FADD IKBKG RELA
7
Show member pathways
12.63 CASP8 FADD IKBKG RELA
8
Show member pathways
12.6 CASP8 FADD IKBKG RELA
9
Show member pathways
12.52 CXCL12 FADD IKBKG RELA
10
Show member pathways
12.5 CASP8 IKBKG RB1 RELA
11
Show member pathways
12.39 CASP8 CXCL12 FADD IKBKG RELA
12 12.35 CASP8 CXCL12 FADD IKBKG RB1 RELA
13
Show member pathways
12.34 CASP8 FADD RB1
14
Show member pathways
12.33 CASP8 IKBKG RB1 RELA
15
Show member pathways
12.28 CASP8 IKBKG RELA
16
Show member pathways
12.27 CASP8 IKBKG RELA
17 12.26 IKBKG RB1 RELA
18
Show member pathways
12.14 CASP8 FADD IKBKG
19
Show member pathways
12.11 CASP8 FADD RB1
20
Show member pathways
12.11 CASP8 IKBKG RELA
21
Show member pathways
12.11 CASP8 FADD IKBKG RELA
22
Show member pathways
12.09 CASP8 FADD IKBKG RELA
23 12.07 CASP8 FADD RELA
24
Show member pathways
12.05 CASP8 IKBKG RELA
25
Show member pathways
12.05 CASP8 CUL5 CXCL12 FADD IKBKG RB1
26 12.04 CASP8 IKBKG RB1 RELA
27
Show member pathways
11.98 CASP8 FADD IKBKG
28 11.98 CASP8 FADD RB1
29
Show member pathways
11.86 CASP8 IKBKG RELA
30 11.73 CXCL12 IKBKG RELA
31 11.71 IKBKG RB1 RELA
32 11.66 CASP8 FADD IKBKG RB1 RELA
33
Show member pathways
11.63 CXCL12 IKBKG RELA
34 11.6 CASP8 FADD IKBKG RELA
35 11.41 CASP8 FADD RELA
36
Show member pathways
11.4 IKBKG RELA
37 11.38 RB1 RELA
38 11.36 CASP8 RB1
39 11.32 CASP8 FADD
40 11.27 CASP8 RELA
41 11.22 CASP8 FADD RELA
42 11.16 IKBKG RELA
43 11.16 CASP8 IKBKG RELA
44 11.05 RB1 RELA
45 11.03 IKBKG RELA
46 11 IKBKG RELA
47 10.95 IKBKG RELA
48 10.51 IKBKG RELA

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 death-inducing signaling complex GO:0031264 9.16 CASP8 FADD
2 CD95 death-inducing signaling complex GO:0031265 8.96 CASP8 FADD
3 ripoptosome GO:0097342 8.62 CASP8 FADD

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.87 CASP8 FADD IKBKG RB1
2 extrinsic apoptotic signaling pathway GO:0097191 9.58 CASP8 FADD
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 CASP8 FADD
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.56 CASP8 FADD IKBKG RELA
5 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.55 CASP8 FADD
6 response to morphine GO:0043278 9.54 FADD RELA
7 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.52 CASP8 IKBKG
8 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.51 CASP8 IKBKG
9 positive regulation of proteolysis GO:0045862 9.49 CASP8 FADD
10 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.48 CASP8 FADD
11 activation of cysteine-type endopeptidase activity GO:0097202 9.46 CASP8 FADD
12 toll-like receptor 3 signaling pathway GO:0034138 9.43 CASP8 FADD
13 death-inducing signaling complex assembly GO:0071550 9.4 CASP8 FADD
14 regulation of necroptotic process GO:0060544 9.37 CASP8 FADD
15 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.33 CASP8 FADD IKBKG
16 TRAIL-activated apoptotic signaling pathway GO:0036462 9.32 CASP8 FADD
17 viral process GO:0016032 9.17 CASP8 CUL5 CXCL12 FADD IKBKG RB1
18 positive regulation of macrophage differentiation GO:0045651 9.13 CASP8 FADD RB1

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.77 CASP8 FADD IKBKG RB1 RELA
2 protein-containing complex binding GO:0044877 9.46 CARMIL2 CASP8 FADD RELA
3 tumor necrosis factor receptor binding GO:0005164 9.4 CASP8 FADD
4 structural constituent of epidermis GO:0030280 9.32 FLG LOR
5 death receptor binding GO:0005123 9.26 CASP8 FADD
6 ubiquitin protein ligase binding GO:0031625 9.02 CASP8 CUL5 IKBKG RB1 RELA
7 death effector domain binding GO:0035877 8.96 CASP8 FADD

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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