Aliases & Classifications for Molluscum Contagiosum

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.

MalaCards based summary : Molluscum Contagiosum is related to kaposi sarcoma and hyper-ige recurrent infection syndrome, autosomal recessive, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways/superpathways are Keratinization and Viral carcinogenesis. The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related phenotype is immune system.

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 76 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results... more...

Related Diseases for Molluscum Contagiosum

Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 kaposi sarcoma 29.0 CASP8 CCR8 IFNB1
2 hyper-ige recurrent infection syndrome, autosomal recessive 11.2
3 b-cell expansion with nfkb and t-cell anergy 11.2
4 dermatitis 10.4
5 dermatitis, atopic 10.4
6 cryptococcosis 10.3
7 acquired immunodeficiency syndrome 10.3
8 herpes simplex 10.3
9 dermatitis, atopic, 2 10.2 FLG LOR
10 epidermoid cysts 10.2
11 psoriasis 10.2
12 langerhans cell histiocytosis 10.2
13 lymphoma 10.2
14 lepromatous leprosy 10.2
15 histiocytosis 10.2
16 epidermodysplasia verruciformis 10.1
17 basal cell carcinoma 1 10.1
18 basal cell carcinoma 10.1
19 vaccinia 10.1
20 cellulitis 10.1
21 hyper ige syndrome 10.1
22 cutaneous pseudolymphoma 10.1
23 ichthyosis vulgaris 10.1 FLG LOR
24 aging 10.0
25 burns 10.0
26 erythema multiforme 10.0
27 methemoglobinemia 10.0
28 sarcoma 10.0
29 anogenital venereal wart 10.0
30 histoplasmosis 10.0
31 squamous cell carcinoma 10.0
32 papilloma 10.0
33 folliculitis 10.0
34 scabies 10.0
35 herpes zoster 10.0
36 epidermolytic hyperkeratosis 10.0 FLG LOR
37 retinoblastoma 9.9
38 rheumatoid arthritis 9.9
39 focal epithelial hyperplasia, oral 9.9
40 mycosis fungoides 9.9
41 myeloma, multiple 9.9
42 wiskott-aldrich syndrome 9.9
43 asthma 9.9
44 human immunodeficiency virus type 1 9.9
45 leukemia, acute lymphoblastic 9.9
46 arthritis 9.9
47 b-cell lymphomas 9.9
48 crohn's disease 9.9
49 granuloma annulare 9.9
50 hepatitis 9.9

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

MGI Mouse Phenotypes related to Molluscum Contagiosum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CARMIL2 CASP8 CCR8 CORO1A IFNB1 IKBKG

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3,Phase 2,Not Applicable 56-25-7
2 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3
3
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
4 tannic acid Approved, Nutraceutical Not Applicable
5 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
2 Cantharidin Application in Molluscum Patients Recruiting NCT03377803 Phase 3 VP-102;Placebo
3 Cantharidin Application in Molluscum Patients-1 Recruiting NCT03377790 Phase 3 VP-102;Placebo
4 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
5 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
6 Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum. Recruiting NCT03186378 Phase 2 VP-102
7 A Study to Evaluate the Safety and Efficacy of SB206 in Subjects With Molluscum Contagiosum Recruiting NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
8 A Study of VBP-245 in Pediatric Patients With Molluscum Contagiosum Active, not recruiting NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
9 A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum Terminated NCT02024581 Phase 2 10% East Indian sandalwood oil cream;Placebo Cream
10 Efficacy of Cantharidin in Molluscum Contagiosum Completed NCT00667225 Not Applicable cantharidin's vehicle;Cantharidin 0.7%
11 Picato for the Treatment of Molluscum Contagiosum in Immunocompromised Patients Recruiting NCT03336372 Early Phase 1 Picato
12 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822 Not Applicable

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

19
Skin

MalaCards organs/tissues related to Molluscum Contagiosum:

41
Skin, T Cells, Cervix, Lung, Bone Marrow, Myeloid, Bone

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 636)
# Title Authors Year
1
Comment on "Molluscum contagiosum: Review and update on management". ( 29575072 )
2018
2
Langerhans cell histiocytosis mimicking molluscum contagiosum: A case series. ( 29528195 )
2018
3
Efficacy and safety of topical application of 15% and 10% potassium hydroxide for the treatment of Molluscum contagiosum. ( 29479727 )
2018
4
Update on the Treatment of molluscum Contagiosum in children. ( 29576186 )
2018
5
Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency. ( 29282454 )
2018
6
Molluscum contagiosum arising in a melanocytic congenital nevus. ( 29971818 )
2018
7
Efficacy of combination therapies of topical 5% imiquimod and liquid nitrogen for penile molluscum contagiosum. ( 29667708 )
2018
8
Treatment of molluscum contagiosum with hydrogen peroxide. ( 29058324 )
2018
9
Cantharidin for treatment of facial molluscum contagiosum: A retrospective review. ( 29241785 )
2018
10
Image Gallery: Molluscum contagiosum-like facial lesions in a patient with a renal transplant: deep dermatophytosis due to Trichophyton rubrum. ( 29785830 )
2018
11
An unusual presentation of giant molluscum contagiosum diagnosed on cytology. ( 29736921 )
2018
12
Expression of YAP and TAZ in molluscum contagiosum virus infected skin. ( 29330849 )
2018
13
Oral Echinacea exerts complete clearing of multiple facial molluscum contagiosum in a young black patient. ( 29582619 )
2018
14
Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. ( 29904968 )
2018
15
Imiquimod cream for molluscum contagiosum: Neither safe nor effective. ( 29575068 )
2018
16
Use of a disposable ear speculum: An alternative technique for molluscum contagiosum curettage. ( 29575222 )
2018
17
Complete resolution of facial molluscum contagiosum in a HIV-infected patient by antiretroviral therapy. ( 28971509 )
2018
18
Expanding the Morphologic Heterogeneity of Stromal Changes in Molluscum Contagiosum Infection. ( 29329128 )
2018
19
A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. ( 29393023 )
2018
20
Periocular molluscum contagiosum: six different clinical presentations. ( 29855150 )
2018
21
Autoinoculation as a treatment modality for molluscum contagiosum: A preliminary uncontrolled trial. ( 29251278 )
2018
22
Molluscum contagiosum in immunocompromised patients: AIDS presenting as molluscum contagiosum in a patient with psoriasis on biologic therapy. ( 29554156 )
2018
23
An unusual reaction to molluscum contagiosum. ( 29319288 )
2018
24
Molluscum contagiosum: an update. ( 28521677 )
2017
25
Melan A Antibody Cross-Reactivity in Molluscum Contagiosum Bodies. ( 28805130 )
2017
26
Molluscum Contagiosum in a Patient with Atopic Dermatitis. ( 29166239 )
2017
27
Molluscum Contagiosum of the Gluteal Cleft: Observations and Implications for Management in Five Children. ( 28543922 )
2017
28
The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions. ( 28425034 )
2017
29
Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2. ( 28555548 )
2017
30
Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children. ( 28871935 )
2017
31
Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis. ( 28866311 )
2017
32
Desmoplastic trichilemmoma dermoscopically mimicking molluscum contagiosum. ( 28087019 )
2017
33
A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. ( 28670845 )
2017
34
Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015 ( 28806866 )
2017
35
Molluscum contagiosum and pubic hair removal in male patients. ( 29027896 )
2017
36
Molluscum Contagiosum: A Rare Nipple Lesion. ( 27670745 )
2017
37
Molluscum Contagiosum ( 28722927 )
2017
38
Disseminated molluscum contagiosum lesions in an HIV patient. ( 28322681 )
2017
39
Limited treatment options for molluscum contagiosum. ( 28768690 )
2017
40
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. ( 28845328 )
2017
41
Molluscum Contagiosum Treated with Dilute Povidone-Iodine: A Series of Cases. ( 28360968 )
2017
42
ELISA for Molluscum Contagiosum Virus. ( 29120484 )
2017
43
Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination. ( 28515292 )
2017
44
Congenital molluscum contagiosum. ( 29479224 )
2017
45
Molluscum Contagiosum-Like Presentation of Langerhans Cell Histiocytosis: A Case and Review. ( 28730670 )
2017
46
Interventions for cutaneous molluscum contagiosum. ( 28513067 )
2017
47
Topical evening primrose oil as a possible therapeutic alternative in children with molluscum contagiosum. ( 28940438 )
2017
48
Molluscum Contagiosum: Review and Update on Management. ( 28884917 )
2017
49
Corpora amylacea and molluscum contagiosum on a cervical pap smear. ( 27863182 )
2017
50
Molluscum Contagiosum Virus Protein MC005 Inhibits NF-I_B Activation by Targeting NEMO-Regulated II_B Kinase Activation. ( 28490597 )
2017

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 CSTA FLG LOR
2 11.74 CASP8 CCR8 IKBKG
3 11.58 CASP8 CORO1A IFNB1
4
Show member pathways
11.44 CASP8 CCR8 IFNB1 IKBKG
5 10.99 CASP8 IFNB1
6 10.93 CASP8 IKBKG
7 10.34 IFNB1 IKBKG

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell leading edge GO:0031252 8.96 CARMIL2 CORO1A
2 cornified envelope GO:0001533 8.8 CSTA FLG LOR

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.4 CASP8 IKBKG
2 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.37 CASP8 IKBKG
3 cornification GO:0070268 9.33 CSTA FLG LOR
4 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.32 CASP8 IKBKG
5 natural killer cell activation GO:0030101 9.26 CASP8 IFNB1
6 keratinocyte differentiation GO:0030216 9.13 CSTA FLG LOR
7 peptide cross-linking GO:0018149 8.8 CSTA FLG LOR

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 CSTA FLG LOR
2 structural constituent of epidermis GO:0030280 8.62 FLG LOR

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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