MCID: MLL001
MIFTS: 50

Molluscum Contagiosum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Molluscum Contagiosum

MalaCards integrated aliases for Molluscum Contagiosum:

Name: Molluscum Contagiosum 12 74 54 3 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8867
ICD9CM 34 078.0
MeSH 43 D008976
NCIt 49 C155872
SNOMED-CT 67 40070004
ICD10 32 B08.1
UMLS 71 C0026393

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years. The lesions, known as Mollusca, are small, raised, and usually white, pink, or flesh-colored with a dimple or pit in the center. They often have a pearly appearance. They're usually smooth and firm. In most people, the lesions range from about the size of a pinhead to as large as a pencil eraser (2 to 5 millimeters in diameter). They may become itchy, sore, red, and/or swollen. Mollusca may occur anywhere on the body including the face, neck, arms, legs, abdomen, and genital area, alone or in groups. The lesions are rarely found on the palms of the hands or the soles of the feet.

MalaCards based summary : Molluscum Contagiosum is related to hyper ige syndrome and dermatitis, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is CASP8 (Caspase 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cantharidin and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 74 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results... more...

Related Diseases for Molluscum Contagiosum

Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 hyper ige syndrome 31.3 TNF TLR9 TLR3 TLR2
2 dermatitis 29.9 TNF TLR9 LORICRIN IVL FLG CARMIL2
3 immune deficiency disease 29.9 TNF TLR9 TLR2 IKBKG CXCL12 CCR8
4 kaposi sarcoma 29.9 TLR3 RELA IKBKG FADD CCR8 CASP8
5 skin disease 29.8 TNF TLR2 LORICRIN IVL FLG CASP8
6 anogenital venereal wart 29.8 TLR9 TLR3 TLR2
7 crohn's disease 29.6 TNF TLR9 TLR2 IL18BP
8 lichen planus 29.5 TNF TLR2 IVL FLG
9 chlamydia 29.4 TNF TLR9 TLR2
10 leprosy 3 29.4 TNF TLR9 TLR3 TLR2
11 toxoplasmosis 29.3 TNF TLR9 TLR2
12 herpes simplex 29.3 TNF TLR9 TLR3 TLR2 CASP8
13 psoriasis 29.1 TNF TLR9 TLR2 LORICRIN IVL FLG
14 bacterial infectious disease 28.9 TNF TLR9 TLR3 TLR2
15 dermatitis, atopic 28.8 TNF TLR9 TLR3 TLR2 LORICRIN IVL
16 rheumatoid arthritis 28.7 TNF TLR9 TLR2 IL18BP FLG CXCL12
17 chickenpox 28.7 TNF TLR9 TLR3 TLR2
18 myeloma, multiple 28.7 TNF TLR9 TLR3 RELA CXCL12 CASP8
19 measles 28.6 TNF TLR9 TLR3 TLR2
20 immunodeficiency 58 11.8
21 hyper-ige recurrent infection syndrome 2, autosomal recessive 11.5
22 b-cell expansion with nfkb and t-cell anergy 11.5
23 acquired immunodeficiency syndrome 10.8
24 vaccinia 10.8
25 conjunctivitis 10.7
26 human immunodeficiency virus type 1 10.6
27 cryptococcosis 10.6
28 smallpox 10.6
29 hansen's disease 10.6
30 epidermoid cysts 10.5
31 pustulosis of palm and sole 10.5
32 squamous cell papilloma 10.5
33 papilloma 10.5
34 variola major 10.5
35 keratitis, hereditary 10.4
36 dowling-degos disease 1 10.4
37 langerhans cell histiocytosis 10.4
38 exanthem 10.4
39 basal cell carcinoma 10.4
40 histiocytosis 10.4
41 herpes zoster 10.4
42 keratoconjunctivitis 10.4
43 neuroretinitis 10.4
44 lepromatous leprosy 10.4
45 histoplasmosis 10.4
46 retinitis 10.4
47 lymphopenia 10.4
48 scabies 10.4
49 epidermodysplasia verruciformis 1 10.3
50 human herpesvirus 8 10.3

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

MGI Mouse Phenotypes related to Molluscum Contagiosum:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CARMIL2 CASP8 CUL5 CXCL12 FADD IKBKG
2 cardiovascular system MP:0005385 10.07 CASP8 CUL5 CXCL12 FADD IKBKG RB1
3 immune system MP:0005387 10.03 CARMIL2 CASP8 CCR8 CUL5 CXCL12 FADD
4 endocrine/exocrine gland MP:0005379 10.02 CARMIL2 CASP8 FADD IKBKG IL18BP RB1
5 liver/biliary system MP:0005370 9.61 CASP8 CXCL12 FADD IKBKG IL18BP RB1
6 muscle MP:0005369 9.23 CASP8 CXCL12 FADD RB1 RELA TLR2

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cantharidin Approved, Investigational Phase 3 56-25-7
2
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
3
Lenograstim Approved, Investigational Phase 2 135968-09-1
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5
Busulfan Approved, Investigational Phase 2 55-98-1 2478
6 Immunosuppressive Agents Phase 2
7 Alkylating Agents Phase 2
8 Immunologic Factors Phase 2
9 Anesthetics Phase 2
10 Antirheumatic Agents Phase 2
11 Antimetabolites Phase 2
12
Nitric Oxide Approved Phase 1 10102-43-9 145068
13 Orange Approved Phase 1
14
tannic acid Approved 1401-55-4
15
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
16
Ethanol Approved 64-17-5 702
17 Dermatologic Agents
18 Pharmaceutical Solutions
19 Omega 3 Fatty Acid Early Phase 1

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerance of the Topical Application of Potassium Hydroxide (10% and 15%) in the Treatment of Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
2 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377803 Phase 3 VP-102;Placebo
3 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Pivotal Study to Evaluate the Safety and Efficacy of VP-102 Topical Film-Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03377790 Phase 3 VP-102;Placebo
4 A Phase 3 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study Comparing the Efficacy and Safety of SB206 and Vehicle Gel Once Daily in the Treatment of Molluscum Contagiosum Completed NCT03927716 Phase 3 SB206 12%;Placebo
5 A Phase 3 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study Comparing the Efficacy and Safety of SB206 and Vehicle Gel Once Daily in the Treatment of Molluscum Contagiosum Completed NCT03927703 Phase 3 SB206 12%;Placebo
6 A Multicenter, Randomized, Double-Blind, Vehicle-Controlled Phase II Study to Evaluate the Efficacy, Tolerability, and Safety of VBP-245 in Pediatric Subjects for the Treatment of Molluscum Contagiosum Completed NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
7 Randomized Pilot Study Investigating the Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
8 A Phase 2 Multi-Center, Randomized, Double-Blind, Vehicle-Controlled Ascending Dose Study of SB206 in Subjects With Molluscum Contagiosum Completed NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
9 A Phase 2, Open-Label Study to Evaluate the Safety, Efficacy and Systemic Exposure of VP-102 Topical Film Forming Solution [0.7% (w/v) Cantharidin] in Subjects (2 Years and Older) With Molluscum Contagiosum Completed NCT03186378 Phase 2
10 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
11 Related and Unrelated Donor Hematopoietic Stem Cell Transplant of DOCK8 Deficiency Recruiting NCT01176006 Phase 2 Fludarabine(Fludara, Berlex Laboratories);Cyclophosphamide(CTX, Cytoxan);Busulfan (Busulfex)
12 A Multi-center, Double-blind, Placebo-controlled, Randomized Safety and Efficacy Trial of a Botanical Drug Product Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum in Pediatric Subjects Terminated NCT02024581 Phase 2 10% East Indian sandalwood oil cream;Placebo Cream
13 A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers Unknown status NCT03183830 Phase 1
14 Picato for the Treatment of Molluscum Contagiosum in Immunocompromised Patients Unknown status NCT03336372 Early Phase 1 Picato
15 Efficacy of Cantharidin in Molluscum Contagiosum: A Randomized, Blinded, Placebo-Controlled Prospective Study Completed NCT00667225 cantharidin's vehicle;Cantharidin 0.7%
16 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822
17 Using a Cold Atmospheric Plasma Device to Treat Skin Disorders Recruiting NCT02759900
18 Pro-Resolving Mediators in Acute Inflammation in Humans Recruiting NCT04308889 Early Phase 1 Lovaza

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cantharidin

Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

19
Skin

MalaCards organs/tissues related to Molluscum Contagiosum:

40
Skin, T Cells, Eye, Cervix, Kidney, Testes, Myeloid

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 1616)
# Title Authors PMID Year
1
Molluscum contagiosum prevents progression of staphylococcal scalded skin syndrome. 54 61
16091916 2005
2
Lamellarins, from A to Z: a family of anticancer marine pyrrole alkaloids. 61 54
15281908 2004
3
Interleukin-18 and glycosaminoglycan binding by a protein encoded by Variola virus. 61 54
15105546 2004
4
Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. 61 54
12552001 2003
5
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. 61 54
11752160 2002
6
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. 61 54
11493620 2001
7
A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. 54 61
10620615 2000
8
An immunohistochemical study of abnormal keratinocyte differentiation in molluscum contagiosum. 54 61
10417525 1999
9
Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining. 61 54
10228630 1999
10
Molluscum contagiosum in pediatric patients: to treat or not to treat? Could a personalized imiquimod regimen be the answer to the dilemma? 61
32347136 2020
11
Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. 61
32510303 2020
12
Transitory Dissemination of Molluscum Contagiosum in a Patient Treated with Dupilumab for Atopic Dermatitis. 61
32556344 2020
13
Hypertrophic genital herpes in an HIV-infected female patient: Imiquimod as an alternative treatment. 61
32311452 2020
14
Cantharidin for molluscum contagiosum. 61
32532721 2020
15
SB206, a New Topical Nitric Oxide-Releasing Drug on the Horizon for the Treatment of Molluscum Contagiosum and External Anogenital Warts. 61
32400176 2020
16
Atypical presentation of genital molluscum contagiosum mimicking genital warts. 61
32438855 2020
17
[Viral conjunctivitis due to molluscum contagiosum in a young immunocompetent woman]. 61
32327278 2020
18
Efficacy and tolerability of an investigational nitric oxide-releasing topical gel in patients with molluscum contagiosum: A randomized clinical trial. 61
31586600 2020
19
Cutaneous Cryosurgery for Common Skin Conditions. 61
32227823 2020
20
African histoplasmosis in a Guinea Bissau patient with HIV-2: Case report and review. 61
31706701 2020
21
Pemphigus-like eruption as a complication of molluscum contagiosum treatment with imiquimod in a 5-year-old girl. 61
32027759 2020
22
The influence of clinical features mimicking primary immunodeficiency diseases (mPID) on children with Langerhans cell histiocytosis (LCH) - Four with mPID among 39 LCH children from one referral center during 18-year period. 61
31862125 2020
23
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 61
32049716 2020
24
The molluscum contagiosum BOTE sign-Infected or inflamed? 61
32115769 2020
25
Optical coherence tomography in an eyelid lesion due to Molluscum contagiosum. 61
31740279 2020
26
Molluscum contagiosum mimicking condyloma acuminata in a renal transplant patient: A unique presentation. 61
31860768 2020
27
Diversity of XMEN Disease: Description of 2 Novel Variants and Analysis of the Lymphocyte Phenotype. 61
31865525 2020
28
Eyelid and Orbital Involvement in HIV Infection - An African Perspective. 61
32058857 2020
29
Skin Infections and Outpatient Burn Management: Fungal and Viral Skin Infections. 61
31995350 2020
30
[DISSEMINATED CRYPTOCOCCOSIS IN A LIVER TRANSPLANT RECIPIENT DIAGNOSED BY TZANCK SMEAR]. 61
31930800 2020
31
[Young male patient with unusual space-occupying lesion of the lower eyelid]. 61
31359135 2020
32
Plantar Molluscum Contagiosum With Dermoscopic Features. 61
32363099 2020
33
Subungual Molluscum Contagiosum: A Rare Presentation. 61
32021865 2020
34
Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus. 61
31922947 2020
35
A case of disseminated molluscum contagiosum caused by topical calcipotriol/betamethasone in an immunocompetent adult. 61
31951078 2020
36
Ingenol mebutate gel for the treatment of molluscum contagiosum: An open-label comparative pilot study. 61
31499155 2020
37
Acute ulceronecrotic adverse reaction to potassium hydroxide 5% solution in the treatment of molluscum contagiosum. 61
31625620 2020
38
Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% Potassium hydroxide for molluscum contagiosum treatment in children. 61
30668179 2019
39
Oral echinacea exerts complete clearing of multiple facial molluscum contagiosum in a young black patient. 61
29582619 2019
40
Sexually Transmitted Infections in Soldiers - A Cross-Sectional Assessment in German Paratroopers and Navy Soldiers and a Literature Review. 61
31934366 2019
41
Molluscum Contagiosum in Interdigital Area of Foot in a Pregnant Patient. 61
31807471 2019
42
Molluscum contagiosum infection with features of primary cutaneous anaplastic large cell lymphoma. 61
32045148 2019
43
Clinical diversity of invasive cryptococcosis in AIDS patients from central China: report of two cases with review of literature. 61
31775716 2019
44
Pediatric molluscum: an update. 61
31886783 2019
45
Intralesional vitamin D immunotherapy for recalcitrant molluscum contagiosum. 61
31569284 2019
46
A case of widespread molluscum contagiosum caused by baricitinib, a Janus kinase inhibitor. 61
31012089 2019
47
[Gianotti-Crosti syndrome-like reaction secondary to Molluscum contagiosum]. 61
31635922 2019
48
Secondary syphilis mimicking molluscum contagiosum in the beard area of an AIDS patient. 61
31774899 2019
49
Mucocutaneous manifestations of human immunodeficiency virus (HIV) infection in children in relation to the degree of immunosuppression. 61
30927252 2019
50
Successful treatment of recalcitrant molluscum contagiosum in a stem cell transplant patient with Candida immunotherapy. 61
31222883 2019

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF TLR9 TLR3 TLR2 RELA IL18BP
2
Show member pathways
13.42 TNF TLR9 TLR3 TLR2 IKBKG FADD
3
Show member pathways
13.08 TNF RELA RB1 IKBKG FADD CASP8
4
Show member pathways
12.97 TNF TLR3 TLR2 RELA RB1 IKBKG
5
Show member pathways
12.94 TNF TLR9 TLR3 TLR2 RELA RB1
6 12.76 RELA RB1 IKBKG FADD ELOC ELOB
7
Show member pathways
12.73 TNF TLR9 TLR3 TLR2 RELA IL18BP
8
Show member pathways
12.72 TNF RELA IKBKG FADD CASP8
9 12.66 TNF TLR9 TLR3 TLR2 RELA IKBKG
10
Show member pathways
12.62 TNF TLR9 TLR2 RELA IKBKG
11
Show member pathways
12.56 TNF RELA IKBKG FADD CXCL12 CASP8
12
Show member pathways
12.55 TNF TLR9 TLR3 TLR2 IKBKG FADD
13
Show member pathways
12.54 TNF TLR9 TLR3 TLR2 RELA IKBKG
14 12.52 TNF TLR9 TLR3 TLR2 RELA IKBKG
15
Show member pathways
12.36 TNF RELA IKBKG FADD CASP8
16 12.35 TNF RELA RB1 IKBKG
17 12.34 RELA RB1 IKBKG CCR8 CASP8
18
Show member pathways
12.34 TNF TLR2 RELA IKBKG FADD CASP8
19
Show member pathways
12.32 TNF TLR3 RELA IKBKG
20
Show member pathways
12.32 TNF TLR9 TLR3 TLR2 RELA RB1
21
Show member pathways
12.31 TLR3 IKBKG FADD CASP8
22 12.3 TNF RELA IKBKG FADD CASP8
23
Show member pathways
12.29 TNF TLR2 RELA IKBKG CASP8
24 12.27 TNF RELA IKBKG FADD CASP8
25
Show member pathways
12.27 TNF TLR9 TLR3 TLR2 RELA IKBKG
26
Show member pathways
12.24 TNF TLR9 RELA IKBKG CASP8
27
Show member pathways
12.23 TNF RB1 FADD CASP8
28 12.23 TNF TLR9 TLR2 RELA FADD CASP8
29
Show member pathways
12.23 TNF TLR3 TLR2 RELA RB1 IKBKG
30
Show member pathways
12.22 TNF TLR3 FADD CASP8
31
Show member pathways
12.21 TNF TLR9 TLR2 RELA IKBKG
32 12.2 TNF TLR9 TLR3 TLR2
33 12.01 TNF TLR9 TLR2 RELA IKBKG FADD
34 12 TNF RELA IKBKG FADD CASP8
35
Show member pathways
11.98 TNF TLR9 TLR3 TLR2
36 11.97 TNF RELA IKBKG CXCL12
37 11.96 TNF RELA IKBKG FADD
38 11.87 TNF TLR2 CXCL12
39 11.86 RELA RB1 IKBKG
40
Show member pathways
11.85 TLR9 TLR3 TLR2
41
Show member pathways
11.83 TLR9 TLR3 TLR2 RELA IKBKG CASP8
42 11.82 TLR9 TLR3 TLR2
43
Show member pathways
11.8 RELA IKBKG CXCL12
44
Show member pathways
11.75 TNF RELA IKBKG
45 11.72 TNF RELA IKBKG
46 11.65 TNF TLR2 RELA CASP8
47 11.6 TNF RELA IKBKG
48
Show member pathways
11.58 TNF RELA IKBKG
49 11.56 TNF TLR9 TLR2
50 11.54 TNF RELA RB1

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.71 TNF TLR2 FADD CASP8
2 cell body GO:0044297 9.61 TLR2 FADD CASP8
3 endolysosome membrane GO:0036020 9.46 TLR9 TLR3
4 elongin complex GO:0070449 9.37 ELOC ELOB
5 death-inducing signaling complex GO:0031264 9.32 FADD CASP8
6 ripoptosome GO:0097342 9.26 FADD CASP8
7 Cul5-RING ubiquitin ligase complex GO:0031466 9.16 ELOB CUL5
8 CD95 death-inducing signaling complex GO:0031265 8.96 FADD CASP8
9 cornified envelope GO:0001533 8.8 LORICRIN IVL FLG

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TLR9 TLR3 TLR2 RELA RB1
2 innate immune response GO:0045087 10.13 TLR9 TLR3 TLR2 RELA IKBKG FADD
3 immune response GO:0006955 10.11 TNF TLR9 TLR2 IKBKG CXCL12 CCR8
4 inflammatory response GO:0006954 10.07 TNF TLR9 TLR3 TLR2 RELA IKBKG
5 defense response to virus GO:0051607 9.99 TLR9 TLR3 RELA FADD
6 response to lipopolysaccharide GO:0032496 9.97 TLR2 RELA IL18BP CASP8
7 defense response GO:0006952 9.96 TNF TLR3 RELA CXCL12
8 response to virus GO:0009615 9.92 TNF TLR3 IKBKG CXCL12
9 positive regulation of inflammatory response GO:0050729 9.9 TNF TLR9 TLR3 TLR2
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.89 TNF FADD CASP8
11 positive regulation of JNK cascade GO:0046330 9.88 TNF TLR9 TLR3
12 apoptotic signaling pathway GO:0097190 9.88 TNF TLR3 FADD CASP8
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR9 TLR3 TLR2 RELA IKBKG
14 cellular response to mechanical stimulus GO:0071260 9.87 TLR3 FADD CASP8
15 keratinocyte differentiation GO:0030216 9.85 LORICRIN IVL FLG
16 positive regulation of interleukin-6 production GO:0032755 9.84 TNF TLR9 TLR3 TLR2
17 toll-like receptor signaling pathway GO:0002224 9.83 TLR9 TLR3 TLR2
18 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR9 TLR3 TLR2 FADD
19 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.82 TNF FADD CASP8
20 microglial cell activation GO:0001774 9.82 TNF TLR3 TLR2
21 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.81 TNF IKBKG CASP8
22 extrinsic apoptotic signaling pathway GO:0097191 9.81 TNF TLR3 FADD CASP8
23 viral process GO:0016032 9.81 RELA RB1 IKBKG FADD ELOC ELOB
24 peptide cross-linking GO:0018149 9.79 LORICRIN IVL FLG
25 positive regulation of interferon-beta production GO:0032728 9.79 TLR9 TLR3 TLR2
26 positive regulation of interleukin-12 production GO:0032735 9.78 TLR9 TLR3 TLR2
27 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.77 TNF TLR9 TLR3 RELA IKBKG
28 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.76 TLR3 IKBKG FADD CASP8
29 positive regulation of macrophage differentiation GO:0045651 9.75 RB1 FADD CASP8
30 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TNF TLR9 RELA
31 toll-like receptor 3 signaling pathway GO:0034138 9.73 TLR3 FADD CASP8
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.72 TNF RELA
33 activation of cysteine-type endopeptidase activity GO:0097202 9.72 FADD CASP8
34 I-kappaB phosphorylation GO:0007252 9.72 TLR9 TLR3 TLR2
35 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR9 TLR2
36 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.71 TLR9 TLR3
37 positive regulation of chemokine biosynthetic process GO:0045080 9.71 TNF TLR3
38 regulation of cytokine secretion GO:0050707 9.71 TLR9 TLR2
39 response to molecule of bacterial origin GO:0002237 9.7 TLR9 TLR2
40 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 RELA
41 cellular response to nicotine GO:0071316 9.69 TNF RELA
42 response to UV-B GO:0010224 9.69 RELA IVL
43 positive regulation of interferon-beta biosynthetic process GO:0045359 9.69 TLR9 TLR3
44 regulation of necroptotic process GO:0060544 9.68 FADD CASP8
45 tumor necrosis factor production GO:0032640 9.68 TLR9 TLR2
46 TRAIL-activated apoptotic signaling pathway GO:0036462 9.67 FADD CASP8
47 positive regulation of interleukin-18 production GO:0032741 9.67 TLR9 TLR2
48 necroptotic signaling pathway GO:0097527 9.67 TNF TLR3 FADD
49 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.65 TLR9 TLR3
50 death-inducing signaling complex assembly GO:0071550 9.65 TNF FADD CASP8

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 TNF TLR9 TLR3 TLR2 SH3BP4 RELA
2 protein-containing complex binding GO:0044877 9.63 TLR2 RELA IKBKG FADD CASP8 CARMIL2
3 identical protein binding GO:0042802 9.61 TNF TLR3 TLR2 SH3BP4 RELA RB1
4 pattern recognition receptor activity GO:0038187 9.43 TLR9 TLR2
5 tumor necrosis factor receptor binding GO:0005164 9.43 TNF FADD CASP8
6 structural constituent of epidermis GO:0030280 9.4 LORICRIN FLG
7 death effector domain binding GO:0035877 9.32 FADD CASP8
8 ubiquitin protein ligase binding GO:0031625 9.1 RELA RB1 IKBKG ELOB CUL5 CASP8

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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