MCID: MNC003
MIFTS: 22

Monckeberg Arteriosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Monckeberg Arteriosclerosis

MalaCards integrated aliases for Monckeberg Arteriosclerosis:

Name: Monckeberg Arteriosclerosis 12 15
Monckeberg Medial Calcific Sclerosis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5161
UMLS 71 C0887866

Summaries for Monckeberg Arteriosclerosis

MalaCards based summary : Monckeberg Arteriosclerosis, also known as monckeberg medial calcific sclerosis, is related to arteriosclerosis and end stage renal disease. An important gene associated with Monckeberg Arteriosclerosis is RARRES2 (Retinoic Acid Receptor Responder 2), and among its related pathways/superpathways are 4-1BB Pathway and Chromatin Regulation / Acetylation. The drugs Calcium, Dietary and Calcium have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Monckeberg Arteriosclerosis

Diseases related to Monckeberg Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 arteriosclerosis 10.4
2 end stage renal disease 10.3
3 cardiovascular syphilis 9.8 RARRES2 CMKLR1
4 hutchinson-gilford progeria syndrome 8.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
5 diabetes mellitus, noninsulin-dependent 7.2 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
6 body mass index quantitative trait locus 11 7.0 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Graphical network of the top 20 diseases related to Monckeberg Arteriosclerosis:



Diseases related to Monckeberg Arteriosclerosis

Symptoms & Phenotypes for Monckeberg Arteriosclerosis

MGI Mouse Phenotypes related to Monckeberg Arteriosclerosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 FGF21 SELE SIRT2 SIRT3 SIRT4 SIRT6
2 homeostasis/metabolism MP:0005376 9.96 CTSK FGF21 RARRES2 SELE SIRT2 SIRT3
3 cellular MP:0005384 9.92 CMKLR1 CTSK RARRES2 SELE SIRT2 SIRT3
4 immune system MP:0005387 9.76 CMKLR1 CTSK RARRES2 SELE SIRT3 SIRT6
5 liver/biliary system MP:0005370 9.43 FGF21 SELE SIRT3 SIRT6 SIRT7 VSIR
6 normal MP:0002873 9.1 FGF21 SELE SIRT2 SIRT3 SIRT4 SIRT5

Drugs & Therapeutics for Monckeberg Arteriosclerosis

Drugs for Monckeberg Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium, Dietary
2
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Mechanisms of the Arterial Calcification of the Members Subordinates in the Diabetes (Implication of the System RANK / RANKL / OSTEOPROTEGERINE) Unknown status NCT02431234
2 Morphological, Biomechanical and Functional Properties of the Arterial Wall of Athletes: Impact and Consequences of Mechanical Stress on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Terminated NCT01577576

Search NIH Clinical Center for Monckeberg Arteriosclerosis

Genetic Tests for Monckeberg Arteriosclerosis

Anatomical Context for Monckeberg Arteriosclerosis

Publications for Monckeberg Arteriosclerosis

Articles related to Monckeberg Arteriosclerosis:

# Title Authors PMID Year
1
Monckeberg Arteriosclerosis: A Telltale Sign. 61
28499804 2017
2
Monckeberg medial calcific sclerosis mimicking malignant calcification pattern at mammography. 61
15790721 2005
3
Renal enlargement and Monckeberg arteriosclerosis following injections of hematoporphyrin. 61
14012351 1963

Variations for Monckeberg Arteriosclerosis

Expression for Monckeberg Arteriosclerosis

Search GEO for disease gene expression data for Monckeberg Arteriosclerosis.

Pathways for Monckeberg Arteriosclerosis

Pathways related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
2 12.17 SIRT7 SIRT6 SIRT5 SIRT3 SIRT2
3
Show member pathways
12 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
4
Show member pathways
11.76 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
5 11.25 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
6 11.17 SIRT7 SIRT3 SIRT2
7 10.48 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

GO Terms for Monckeberg Arteriosclerosis

Cellular components related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear telomeric heterochromatin GO:0005724 8.62 SIRT7 SIRT6

Biological processes related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 mitochondrion organization GO:0007005 9.67 SIRT5 SIRT4 SIRT3
2 positive regulation of cold-induced thermogenesis GO:0120162 9.65 SIRT6 FGF21 CMKLR1
3 response to nutrient levels GO:0031667 9.63 SIRT6 SIRT5 FGF21
4 positive regulation of fat cell differentiation GO:0045600 9.56 RARRES2 CMKLR1
5 histone deacetylation GO:0016575 9.55 SIRT3 SIRT2
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.54 SIRT5 SIRT4
7 positive regulation of macrophage chemotaxis GO:0010759 9.52 RARRES2 CMKLR1
8 histone H4 deacetylation GO:0070933 9.51 SIRT7 SIRT2
9 negative regulation of reactive oxygen species metabolic process GO:2000378 9.5 SIRT5 SIRT3 SIRT2
10 peptidyl-lysine deglutarylation GO:0061699 9.43 SIRT7 SIRT5
11 histone H3 deacetylation GO:0070932 9.43 SIRT7 SIRT6 SIRT2
12 protein deglutarylation GO:0061698 9.4 SIRT7 SIRT5
13 peptidyl-lysine desuccinylation GO:0036049 9.37 SIRT7 SIRT5
14 protein ADP-ribosylation GO:0006471 9.35 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
15 peptidyl-lysine deacetylation GO:0034983 9.33 SIRT4 SIRT3 SIRT2
16 protein deacetylation GO:0006476 9.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Molecular functions related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.97 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
2 zinc ion binding GO:0008270 9.88 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
3 NAD+ ADP-ribosyltransferase activity GO:0003950 9.55 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
4 histone deacetylase activity GO:0004407 9.5 SIRT7 SIRT6 SIRT2
5 deacetylase activity GO:0019213 9.46 SIRT7 SIRT6
6 protein deacetylase activity GO:0033558 9.43 SIRT6 SIRT2
7 NAD-dependent histone deacetylase activity GO:0017136 9.43 SIRT6 SIRT3 SIRT2
8 NAD+ binding GO:0070403 9.43 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
9 protein-glutaryllysine deglutarylase activity GO:0061697 9.4 SIRT7 SIRT5
10 protein-succinyllysine desuccinylase activity GO:0036055 9.37 SIRT7 SIRT5
11 NAD-dependent protein deacetylase activity GO:0034979 9.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Sources for Monckeberg Arteriosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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