MCID: MNC003
MIFTS: 23

Monckeberg Arteriosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Monckeberg Arteriosclerosis

MalaCards integrated aliases for Monckeberg Arteriosclerosis:

Name: Monckeberg Arteriosclerosis 12 15
Monckeberg Medial Calcific Sclerosis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5161
UMLS 71 C0887866

Summaries for Monckeberg Arteriosclerosis

MalaCards based summary : Monckeberg Arteriosclerosis, also known as monckeberg medial calcific sclerosis, is related to arteriosclerosis and cardiovascular syphilis. An important gene associated with Monckeberg Arteriosclerosis is RARRES2 (Retinoic Acid Receptor Responder 2), and among its related pathways/superpathways are Metabolism and 4-1BB Pathway. The drugs Calcium, Dietary and Calcium have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Monckeberg Arteriosclerosis

Diseases related to Monckeberg Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 arteriosclerosis 10.2
2 cardiovascular syphilis 10.1 RARRES2 CMKLR1
3 end stage renal disease 10.1
4 diabetic angiopathy 9.6 SELE NOS3
5 carotid stenosis 9.5 SELE NOS3
6 type 2 diabetes mellitus 8.8 SIRT6 SIRT2 SELE RARRES2 NOS3 FGF21
7 diabetes mellitus 8.8 SIRT4 SIRT3 SELE RARRES2 NOS3 FGF21
8 disease of mental health 8.2 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
9 body mass index quantitative trait locus 11 7.8 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Graphical network of the top 20 diseases related to Monckeberg Arteriosclerosis:



Diseases related to Monckeberg Arteriosclerosis

Symptoms & Phenotypes for Monckeberg Arteriosclerosis

MGI Mouse Phenotypes related to Monckeberg Arteriosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 CTSK FGF21 NOS3 SELE SIRT2 SIRT3
2 homeostasis/metabolism MP:0005376 10.06 CTSK FGF21 NOS3 RARRES2 SELE SIRT2
3 cellular MP:0005384 10.02 CMKLR1 CTSK NOS3 RARRES2 SELE SIRT2
4 immune system MP:0005387 9.86 CMKLR1 CTSK NOS3 RARRES2 SELE SIRT3
5 liver/biliary system MP:0005370 9.63 FGF21 NOS3 SELE SIRT3 SIRT6 SIRT7
6 normal MP:0002873 9.5 FGF21 NOS3 SELE SIRT2 SIRT3 SIRT4
7 skeleton MP:0005390 9.17 CTSK FGF21 NOS3 SIRT2 SIRT3 SIRT6

Drugs & Therapeutics for Monckeberg Arteriosclerosis

Drugs for Monckeberg Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium, Dietary
2
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Mechanisms of the Arterial Calcification of the Members Subordinates in the Diabetes (Implication of the System RANK / RANKL / OSTEOPROTEGERINE) Unknown status NCT02431234
2 Morphological, Biomechanical and Functional Properties of the Arterial Wall of Athletes: Impact and Consequences of Mechanical Stress on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Terminated NCT01577576

Search NIH Clinical Center for Monckeberg Arteriosclerosis

Genetic Tests for Monckeberg Arteriosclerosis

Anatomical Context for Monckeberg Arteriosclerosis

Publications for Monckeberg Arteriosclerosis

Articles related to Monckeberg Arteriosclerosis:

# Title Authors PMID Year
1
Monckeberg Medial Calcific Sclerosis of the Temporal Artery Masquerading as Giant Cell Arteritis: Case Reports and Literature Review. 61
32754413 2020
2
Monckeberg Arteriosclerosis: A Telltale Sign. 61
28499804 2017
3
Monckeberg medial calcific sclerosis mimicking malignant calcification pattern at mammography. 61
15790721 2005
4
Renal enlargement and Monckeberg arteriosclerosis following injections of hematoporphyrin. 61
14012351 1963

Variations for Monckeberg Arteriosclerosis

Expression for Monckeberg Arteriosclerosis

Search GEO for disease gene expression data for Monckeberg Arteriosclerosis.

Pathways for Monckeberg Arteriosclerosis

Pathways related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
2
Show member pathways
12.4 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
3 12.17 SIRT7 SIRT6 SIRT5 SIRT3 SIRT2
4
Show member pathways
12 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
5
Show member pathways
11.89 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
6 11.25 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
7 11.17 SIRT7 SIRT3 SIRT2
8 11.11 SELE NOS3
9 10.48 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

GO Terms for Monckeberg Arteriosclerosis

Biological processes related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.67 SIRT6 FGF21 CMKLR1
2 mitochondrion organization GO:0007005 9.62 SIRT5 SIRT4 SIRT3 NOS3
3 negative regulation of reactive oxygen species metabolic process GO:2000378 9.58 SIRT5 SIRT3 SIRT2
4 positive regulation of fat cell differentiation GO:0045600 9.57 RARRES2 CMKLR1
5 response to activity GO:0014823 9.56 RARRES2 FGF21
6 response to nutrient levels GO:0031667 9.56 SIRT6 SIRT5 RARRES2 FGF21
7 histone deacetylation GO:0016575 9.55 SIRT3 SIRT2
8 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.54 SIRT5 SIRT4
9 histone H3 deacetylation GO:0070932 9.54 SIRT7 SIRT6 SIRT2
10 positive regulation of macrophage chemotaxis GO:0010759 9.52 RARRES2 CMKLR1
11 histone H4 deacetylation GO:0070933 9.51 SIRT7 SIRT2
12 peptidyl-lysine deglutarylation GO:0061699 9.48 SIRT7 SIRT5
13 protein deglutarylation GO:0061698 9.46 SIRT7 SIRT5
14 peptidyl-lysine desuccinylation GO:0036049 9.43 SIRT7 SIRT5
15 protein ADP-ribosylation GO:0006471 9.35 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
16 peptidyl-lysine deacetylation GO:0034983 9.33 SIRT4 SIRT3 SIRT2
17 protein deacetylation GO:0006476 9.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Molecular functions related to Monckeberg Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
2 transferase activity GO:0016740 9.99 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
3 zinc ion binding GO:0008270 9.88 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
4 NAD+ ADP-ribosyltransferase activity GO:0003950 9.55 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
5 histone deacetylase activity GO:0004407 9.5 SIRT7 SIRT6 SIRT2
6 deacetylase activity GO:0019213 9.46 SIRT7 SIRT6
7 protein deacetylase activity GO:0033558 9.43 SIRT6 SIRT2
8 NAD-dependent histone deacetylase activity GO:0017136 9.43 SIRT6 SIRT3 SIRT2
9 NAD+ binding GO:0070403 9.43 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2
10 protein-glutaryllysine deglutarylase activity GO:0061697 9.4 SIRT7 SIRT5
11 protein-succinyllysine desuccinylase activity GO:0036055 9.37 SIRT7 SIRT5
12 NAD-dependent protein deacetylase activity GO:0034979 9.1 SIRT7 SIRT6 SIRT5 SIRT4 SIRT3 SIRT2

Sources for Monckeberg Arteriosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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