MCID: MNK002
MIFTS: 41

Monkeypox

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Monkeypox

MalaCards integrated aliases for Monkeypox:

Name: Monkeypox 12 53 3 44 15 73
Monkeypox Virus Infections 43 73
Monkeypox Virus Infection 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3292
ICD10 33 B04
ICD9CM 35 059.01
MeSH 44 D045908
NCIt 50 C128421
SNOMED-CT 68 25157001

Summaries for Monkeypox

Disease Ontology : 12 A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has material basis in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.

MalaCards based summary : Monkeypox, also known as monkeypox virus infections, is related to smallpox and vaccinia, and has symptoms including fever and pruritus. An important gene associated with Monkeypox is C6 (Complement C6), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

MedlinePlus : 43 Monkeypox is a rare viral disease. It occurs mostly in central and western Africa. Wild rodents and squirrels carry it, but it is called monkeypox because scientists saw it first in lab monkeys. In 2003, it was reported in prairie dogs and humans in the U.S. Centers for Disease Control and Prevention

CDC : 3 Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Congo during a period of intensified effort to eliminate smallpox. Since then monkeypox has been reported in humans in other central and western African countries.

Wikipedia : 76 Monkeypox is an infectious disease caused by the monkeypox virus that can occur in certain animals... more...

Related Diseases for Monkeypox

Diseases related to Monkeypox via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 smallpox 10.8
2 vaccinia 10.7
3 viral infectious disease 10.6
4 cowpox 10.4
5 bacterial sepsis 10.1
6 variola major 10.1
7 chickenpox 10.1
8 west nile virus 10.0
9 exanthem 10.0
10 severe acute respiratory syndrome 10.0
11 yellow fever 10.0
12 immunodeficiency due to a late component of complement deficiency 9.9 C6 C8A
13 variola minor 9.8 PRODH SPICE1

Graphical network of the top 20 diseases related to Monkeypox:



Diseases related to Monkeypox

Symptoms & Phenotypes for Monkeypox

UMLS symptoms related to Monkeypox:


fever, pruritus

GenomeRNAi Phenotypes related to Monkeypox according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 CYB5R3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.64 PRODH
3 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.64 PRODH
4 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.64 CYB5R3 PRODH
5 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.64 CYB5R3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.64 PRODH
7 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.64 PRODH
8 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.64 PRODH
9 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.64 CYB5R3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.64 PRODH
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.64 CYB5R3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.64 PRODH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 CYB5R3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 PRODH
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.64 CYB5R3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.64 CYB5R3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.64 CYB5R3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 CYB5R3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.64 PRODH
20 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 PRODH
21 Decreased homologous recombination repair frequency GR00151-A-1 9.26 BCAM C6
22 Decreased homologous recombination repair frequency GR00151-A-2 9.26 BCAM C6

Drugs & Therapeutics for Monkeypox

Drugs for Monkeypox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3,Phase 2,Phase 1
2 Immunologic Factors Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
2 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
3 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
4 Phase I Trial of an Investigational Small Pox Medication Completed NCT00728689 Phase 1 ST-246 Days 1 - 3;ST-246 Days 11 - 13
5 SIGA-246 to Treat Smallpox Withdrawn NCT00303225 Phase 1 Vaccine: SIGA-246
6 Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure Available NCT02080767 Tecovirimat
7 Cohort Study of Healthcare Workers Receiving Imvanex® Enrolling by invitation NCT03745131

Search NIH Clinical Center for Monkeypox

Cochrane evidence based reviews: monkeypox

Genetic Tests for Monkeypox

Anatomical Context for Monkeypox

MalaCards organs/tissues related to Monkeypox:

41
Skin, Lymph Node, T Cells, Liver, Spleen

Publications for Monkeypox

Articles related to Monkeypox:

(show top 50) (show all 323)
# Title Authors Year
1
Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. ( 30453097 )
2019
2
Ghosts of infections past: using archival samples to understand a century of monkeypox virus prevalence among host communities across space and time. ( 29410823 )
2018
3
Evolution of Synonymous Codon Usage Bias in West African and Central African Strains of Monkeypox Virus. ( 29551886 )
2018
4
Genomic characterisation of human monkeypox virus in Nigeria. ( 29361427 )
2018
5
Should we be already worried about Monkeypox? ( 29747868 )
2018
6
Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease. ( 29927927 )
2018
7
Emergence of Monkeypox - West and Central Africa, 1970-2017. ( 29543790 )
2018
8
Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. ( 29573840 )
2018
9
Reemergence of Human Monkeypox in Nigeria, 2017. ( 29619921 )
2018
10
Emergence of monkeypox in West Africa and Central Africa, 1970–2017. ( 29546750 )
2018
11
Strengthening of Surveillance during Monkeypox Outbreak, Republic of the Congo, 2017. ( 29774865 )
2018
12
Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques. ( 29982575 )
2018
13
Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. ( 30234087 )
2018
14
Notes from the Field: Responding to an Outbreak of Monkeypox Using the One Health Approach - Nigeria, 2017-2018. ( 30235181 )
2018
15
Two cases of monkeypox imported to the United Kingdom, September 2018. ( 30255836 )
2018
16
Monkeypox contacts: a puzzling problem. ( 30264710 )
2018
17
Sixty seconds on . . . monkeypox. ( 30279170 )
2018
18
A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. ( 30357851 )
2018
19
Vaccinating against monkeypox in the Democratic Republic of the Congo. ( 30445121 )
2018
20
Presumptive risk factors for monkeypox in rural communities in the Democratic Republic of the Congo. ( 28192435 )
2017
21
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. ( 28331092 )
2017
22
Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo. ( 28892474 )
2017
23
A Nosocomial Outbreak of Human Monkeypox in the Central African Republic. ( 29732376 )
2017
24
Review of poxvirus: emergence of monkeypox. ( 28406414 )
2017
25
Varicella Coinfection in Patients with Active Monkeypox in the Democratic Republic of the Congo. ( 28894977 )
2017
26
Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo. ( 29029147 )
2017
27
Assessing Monkeypox Virus Prevalence in Small Mammals at the Human-Animal Interface in the Democratic Republic of the Congo. ( 28972544 )
2017
28
Toward Understanding the Outcomes of Monkeypox Infection in Human Pregnancy. ( 29029238 )
2017
29
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
30
FDG Uptake in Lymphoid Tissue serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Infection. ( 28814515 )
2017
31
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.). ( 28827792 )
2017
32
Evolution of a Disease Surveillance System: An Increase in Reporting of Human Monkeypox Disease in the Democratic Republic of the Congo, 2001-2013. ( 30123790 )
2017
33
Evaluation of the GeneXpert for Human Monkeypox Diagnosis. ( 27994107 )
2016
34
Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay. ( 27477914 )
2016
35
Finishing monkeypox genomes from short reads: assembly analysis and a neural network method. ( 27585810 )
2016
36
A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox. ( 28003603 )
2016
37
Emerging diseases-the monkeypox epidemic in the Democratic Republic of the Congo. ( 27404372 )
2016
38
Extended Human-to-Human Transmission during a Monkeypox Outbreak in the Democratic Republic of the Congo. ( 27191380 )
2016
39
Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. ( 27467578 )
2016
40
Human Monkeypox: Current State of Knowledge and Implications for the Future. ( 30270859 )
2016
41
Comparative live bioluminescence imaging of monkeypox virus dissemination in a wild-derived inbred mouse (Mus musculus castaneus) and outbred African dormouse (Graphiurus kelleni). ( 25462355 )
2015
42
Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design. ( 26380309 )
2015
43
A phylogeographic investigation of African monkeypox. ( 25912718 )
2015
44
Laboratory Investigations of African Pouched Rats (Cricetomys gambianus) as a Potential Reservoir Host Species for Monkeypox Virus. ( 26517724 )
2015
45
Using the Ground Squirrel (Marmota bobak) as an Animal Model to Assess Monkeypox Drug Efficacy. ( 25944444 )
2015
46
Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus. ( 26246580 )
2015
47
Treatment with Smallpox Antiviral Tecovirimat (ST-246Ar) alone or in Combination with ACAM2000Ar Vaccination is Effective as a Post-Symptomatic Therapy for Monkeypox Virus Infection. ( 25896687 )
2015
48
Attenuation of monkeypox virus by deletion of genomic regions. ( 25462353 )
2015
49
Genetic studies of the susceptibility of classical and wild-derived inbred mouse strains to monkeypox virus. ( 25791934 )
2015
50
Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease. ( 26147658 )
2015

Variations for Monkeypox

Expression for Monkeypox

Search GEO for disease gene expression data for Monkeypox.

Pathways for Monkeypox

GO Terms for Monkeypox

Cellular components related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 BCAM C6 C8A CYB5R3
2 membrane attack complex GO:0005579 8.62 C6 C8A

Biological processes related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 9.26 C6 C8A
2 regulation of complement activation GO:0030449 9.16 C6 C8A
3 complement activation GO:0006956 8.96 C6 C8A
4 cytolysis GO:0019835 8.62 C6 C8A

Molecular functions related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 FAD binding GO:0071949 8.62 CYB5R3 PRODH

Sources for Monkeypox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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