MCID: MNK002
MIFTS: 40

Monkeypox

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Monkeypox

MalaCards integrated aliases for Monkeypox:

Name: Monkeypox 12 53 3 44 15 73
Monkeypox Virus Infections 43 73
Monkeypox Virus Infection 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3292
ICD10 33 B04
ICD9CM 35 059.01
MeSH 44 D045908

Summaries for Monkeypox

Disease Ontology : 12 A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has material basis in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.

MalaCards based summary : Monkeypox, also known as monkeypox virus infections, is related to smallpox and vaccinia, and has symptoms including fever, muscle ache and headache. An important gene associated with Monkeypox is C6 (Complement C6). The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

MedlinePlus : 43 Monkeypox is a rare viral disease. It occurs mostly in central and western Africa. Wild rodents and squirrels carry it, but it is called monkeypox because scientists saw it first in lab monkeys. In 2003, it was reported in prairie dogs and humans in the U.S. Centers for Disease Control and Prevention

CDC : 3 Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Congo during a period of intensified effort to eliminate smallpox. Since then monkeypox has been reported in humans in other central and western African countries.

Wikipedia : 76 Monkeypox is an infectious disease caused by the monkeypox virus. Symptoms begin with fever, headache,... more...

Related Diseases for Monkeypox

Diseases related to Monkeypox via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 smallpox 10.6
2 vaccinia 10.5
3 cowpox 10.3
4 chickenpox 10.0
5 transmitted_by 10.0
6 type i 10.0
7 west nile virus 9.8
8 exanthem 9.8
9 severe acute respiratory syndrome 9.8
10 yellow fever 9.8
11 variola minor 9.3 PRODH SPICE1

Graphical network of the top 20 diseases related to Monkeypox:



Diseases related to Monkeypox

Symptoms & Phenotypes for Monkeypox

Symptoms:

12
  • fever
  • muscle ache
  • headache
  • lymphadenopathy

UMLS symptoms related to Monkeypox:


fever, pruritus

GenomeRNAi Phenotypes related to Monkeypox according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 CYB5R3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.64 PRODH
3 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.64 PRODH
4 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.64 CYB5R3 PRODH
5 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.64 CYB5R3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.64 PRODH
7 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.64 PRODH
8 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.64 PRODH
9 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.64 CYB5R3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.64 PRODH
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.64 CYB5R3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.64 PRODH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 CYB5R3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 PRODH
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.64 CYB5R3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.64 CYB5R3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.64 CYB5R3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 CYB5R3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.64 PRODH
20 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 PRODH
21 Decreased homologous recombination repair frequency GR00151-A-1 9.61 C6 BCAM VCP
22 Decreased homologous recombination repair frequency GR00151-A-2 9.61 C6 BCAM

Drugs & Therapeutics for Monkeypox

Drugs for Monkeypox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3,Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
2 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
3 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
4 Phase I Trial of an Investigational Small Pox Medication Completed NCT00728689 Phase 1 ST-246 Days 1 - 3;ST-246 Days 11 - 13
5 SIGA-246 to Treat Smallpox Withdrawn NCT00303225 Phase 1 Vaccine: SIGA-246
6 Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure Available NCT02080767 Tecovirimat

Search NIH Clinical Center for Monkeypox

Cochrane evidence based reviews: monkeypox

Genetic Tests for Monkeypox

Anatomical Context for Monkeypox

The Foundational Model of Anatomy Ontology organs/tissues related to Monkeypox:

19
Skin

MalaCards organs/tissues related to Monkeypox:

41
Skin, Lymph Node, T Cells, Liver, Spleen

Publications for Monkeypox

Articles related to Monkeypox:

(show top 50) (show all 308)
# Title Authors Year
1
Ghosts of infections past: using archival samples to understand a century of monkeypox virus prevalence among host communities across space and time. ( 29410823 )
2018
2
Evolution of Synonymous Codon Usage Bias in West African and Central African Strains of Monkeypox Virus. ( 29551886 )
2018
3
Genomic characterisation of human monkeypox virus in Nigeria. ( 29361427 )
2018
4
Should we be already worried about Monkeypox? ( 29747868 )
2018
5
Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease. ( 29927927 )
2018
6
Emergence of Monkeypox - West and Central Africa, 1970-2017. ( 29543790 )
2018
7
Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. ( 29573840 )
2018
8
Reemergence of Human Monkeypox in Nigeria, 2017. ( 29619921 )
2018
9
Strengthening of Surveillance during Monkeypox Outbreak, Republic of the Congo, 2017. ( 29774865 )
2018
10
Emergence of monkeypox in West Africa and Central Africa, 1970a892017. ( 29546750 )
2018
11
Presumptive risk factors for monkeypox in rural communities in the Democratic Republic of the Congo. ( 28192435 )
2017
12
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. ( 28331092 )
2017
13
Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo. ( 28892474 )
2017
14
A Nosocomial Outbreak of Human Monkeypox in the Central African Republic. ( 29732376 )
2017
15
Review of poxvirus: emergence of monkeypox. ( 28406414 )
2017
16
Varicella Coinfection in Patients with Active Monkeypox in the Democratic Republic of the Congo. ( 28894977 )
2017
17
Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo. ( 29029147 )
2017
18
Assessing Monkeypox Virus Prevalence in Small Mammals at the Human-Animal Interface in the Democratic Republic of the Congo. ( 28972544 )
2017
19
Toward Understanding the Outcomes of Monkeypox Infection in Human Pregnancy. ( 29029238 )
2017
20
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
21
FDG Uptake in Lymphoid Tissue serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Infection. ( 28814515 )
2017
22
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.). ( 28827792 )
2017
23
Evaluation of the GeneXpert for Human Monkeypox Diagnosis. ( 27994107 )
2016
24
Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay. ( 27477914 )
2016
25
Finishing monkeypox genomes from short reads: assembly analysis and a neural network method. ( 27585810 )
2016
26
A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox. ( 28003603 )
2016
27
Emerging diseases-the monkeypox epidemic in the Democratic Republic of the Congo. ( 27404372 )
2016
28
Extended Human-to-Human Transmission during a Monkeypox Outbreak in the Democratic Republic of the Congo. ( 27191380 )
2016
29
Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. ( 27467578 )
2016
30
Comparative live bioluminescence imaging of monkeypox virus dissemination in a wild-derived inbred mouse (Mus musculus castaneus) and outbred African dormouse (Graphiurus kelleni). ( 25462355 )
2015
31
Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design. ( 26380309 )
2015
32
A phylogeographic investigation of African monkeypox. ( 25912718 )
2015
33
Laboratory Investigations of African Pouched Rats (Cricetomys gambianus) as a Potential Reservoir Host Species for Monkeypox Virus. ( 26517724 )
2015
34
Using the Ground Squirrel (Marmota bobak) as an Animal Model to Assess Monkeypox Drug Efficacy. ( 25944444 )
2015
35
Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus. ( 26246580 )
2015
36
Treatment with Smallpox Antiviral Tecovirimat (ST-246Ar) alone or in Combination with ACAM2000Ar Vaccination is Effective as a Post-Symptomatic Therapy for Monkeypox Virus Infection. ( 25896687 )
2015
37
Attenuation of monkeypox virus by deletion of genomic regions. ( 25462353 )
2015
38
Genetic studies of the susceptibility of classical and wild-derived inbred mouse strains to monkeypox virus. ( 25791934 )
2015
39
Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease. ( 26147658 )
2015
40
Sequence of pathogenic events in cynomolgus macaques infected with aerosolized monkeypox virus. ( 25653439 )
2015
41
Human Monkeypox in the Kivus, a Conflict Region of the Democratic Republic of the Congo. ( 26283752 )
2015
42
Further Assessment of Monkeypox Virus Infection in Gambian Pouched Rats (Cricetomys gambianus) Using In Vivo Bioluminescent Imaging. ( 26517839 )
2015
43
Introduction of Monkeypox into a Community and Household: Risk Factors and Zoonotic Reservoirs in the Democratic Republic of the Congo. ( 26013374 )
2015
44
Cytokine modulation correlates with severity of monkeypox disease in humans. ( 25600603 )
2015
45
The effect of volume of interest definition on quantification of lymph node immune response to a monkeypox virus infection assessed by (18)F-FDG-PET. ( 26116113 )
2014
46
Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkey. ( 25120821 )
2014
47
Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. ( 24457084 )
2014
48
Evaluation of monkeypox virus infection of black-tailed prairie dogs (Cynomys ludovicianus) using in vivo bioluminescent imaging. ( 24779460 )
2014
49
Fatal monkeypox in wild-living sooty mangabey, CA'te d'Ivoire, 2012. ( 24857667 )
2014
50
A highly specific monoclonal antibody against monkeypox virus detects the heparin binding domain of A27. ( 25108113 )
2014

Variations for Monkeypox

Expression for Monkeypox

Search GEO for disease gene expression data for Monkeypox.

Pathways for Monkeypox

GO Terms for Monkeypox

Cellular components related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.46 BCAM C6 CYB5R3 VCP
2 azurophil granule lumen GO:0035578 8.96 CYB5R3 VCP
3 lipid droplet GO:0005811 8.62 CYB5R3 VCP

Molecular functions related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ADP binding GO:0043531 8.96 CYB5R3 VCP
2 FAD binding GO:0071949 8.62 CYB5R3 PRODH

Sources for Monkeypox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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