MCID: MNK002
MIFTS: 41

Monkeypox

Categories: Immune diseases, Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Monkeypox

MalaCards integrated aliases for Monkeypox:

Name: Monkeypox 12 20 3 44 15 70 32
Monkeypox Virus Infections 70
Monkeypox Virus Infection 20

Classifications:



External Ids:

Disease Ontology 12 DOID:3292
ICD9CM 34 059.01
MeSH 44 D045908
NCIt 50 C128421
SNOMED-CT 67 240466002
ICD10 32 B04
UMLS 70 C0276180 C1456660

Summaries for Monkeypox

Disease Ontology : 12 A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has material basis in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.

MalaCards based summary : Monkeypox, also known as monkeypox virus infections, is related to variola major and exanthem, and has symptoms including fever and pruritus. An important gene associated with Monkeypox is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Vaccines and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

CDC : 3 Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.' The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Congo during a period of intensified effort to eliminate smallpox. Since then monkeypox has been reported in humans in other central and western African countries.

Wikipedia : 73 Monkeypox is an infectious disease caused by the monkeypox virus that can occur in certain animals... more...

Related Diseases for Monkeypox

Diseases related to Monkeypox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 variola major 31.9 CYB5R3 CD8A CD4
2 exanthem 31.3 IFNA1 CD8A CD4
3 chickenpox 31.1 IFNA1 CD8A CD4
4 variola minor 30.8 CYB5R3 CD55 CD46
5 cowpox 30.8 KLRK1 CD8A CD4
6 viral infectious disease 29.2 KLRK1 IRF3 IFNA1 CD46 CD4
7 smallpox 11.0
8 vaccinia 10.8
9 cork-handlers' disease 10.4 CD8A CD4
10 necrotic uveal melanoma 10.4 CD8A CD4
11 early yaws 10.4 CD8A CD4
12 ventilation pneumonitis 10.4 CD8A CD4
13 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
14 latent syphilis 10.4 CD8A CD4
15 type 1 diabetes mellitus 23 10.4 CD8A CD4
16 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
17 parapsoriasis 10.4 CD8A CD4
18 primary syphilis 10.4 CD8A CD4
19 norwegian scabies 10.4 CD8A CD4
20 bird fancier's lung 10.4 CD8A CD4
21 metal allergy 10.4 CD8A CD4
22 follicular mucinosis 10.4 CD8A CD4
23 tertiary syphilis 10.4 CD8A CD4
24 spongiotic dermatitis 10.4 CD8A CD4
25 acute retinal necrosis syndrome 10.4 CD8A CD4
26 cerebral lymphoma 10.4 CD8A CD4
27 cerebritis 10.4 CD8A CD4
28 invasive malignant thymoma 10.4 CD8A CD4
29 west nile encephalitis 10.4 CD8A CD4
30 granulomatous hepatitis 10.4 CD8A CD4
31 immunodeficiency 36 10.4 CD8A CD4
32 disease by infectious agent 10.4
33 viral exanthem 10.4 CD8A CD4
34 secondary syphilis 10.3 CD8A CD4
35 glanders 10.3 CD8A CD4
36 oral hairy leukoplakia 10.3 CD8A CD4
37 mononeuritis of upper limb and mononeuritis multiplex 10.3 CD4 CCL26
38 mononeuritis multiplex 10.3 CD4 CCL26
39 parotid disease 10.3 CD8A CD4
40 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.3 CD8A CD4
41 wissler-fanconi syndrome 10.3 IFNA1 CD4
42 ulcerative stomatitis 10.3 CD8A CD4
43 granulomatous dermatitis 10.3 CD8A CD4
44 neurosarcoidosis 10.3 CD8A CD4
45 gastroduodenitis 10.3 CD8A CD4 CCL26
46 retinitis pigmentosa 46 10.3 CD8A CD4
47 hantavirus hemorrhagic fever with renal syndrome 10.3 CD8A CD55 CD4
48 marburg hemorrhagic fever 10.3 IFNA1 CD8A
49 esophageal candidiasis 10.3 CD8A CD4 CCL26
50 pneumonic tularemia 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Monkeypox:



Diseases related to Monkeypox

Symptoms & Phenotypes for Monkeypox

UMLS symptoms related to Monkeypox:


fever; pruritus

GenomeRNAi Phenotypes related to Monkeypox according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 IFNA1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.21 C4A C4B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.21 CCL26
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.21 CCL26 KLRC3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-14 10.21 IFNA1 CD4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-142 10.21 KLRC3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.21 IFNA1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.21 CD4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-148 10.21 KLRC3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-160 10.21 CD4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 C4A C4B CCL26
12 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.21 KLRC3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.21 CD46
14 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.21 CCL26
15 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.21 IFNA1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-175 10.21 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.21 CD4
18 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.21 KLRC3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-20 10.21 KLRC3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-209 10.21 IFNA1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.21 CD4
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.21 C4A C4B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.21 IFNA1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 C4A C4B CCL26 KLRC3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-64 10.21 CD46
26 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.21 CCL26
27 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.21 IFNA1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.21 IFNA1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.21 C4A C4B IFNA1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-84 10.21 KLRC3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.21 CCL26

Drugs & Therapeutics for Monkeypox

Drugs for Monkeypox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
2 An Open-Label Prospective Cohort Study of IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Active, not recruiting NCT02977715 Phase 3
3 A Phase I Randomized, Double-Blind, Crossover, Exploratory Study of the Pharmacokinetics of a Single Oral Dose of Form I Versus Form V Capsules of the Anti-Orthopoxvirus Compound ST-246® in Fed Normal Healthy Volunteers Completed NCT00728689 Phase 1 ST-246 Days 1 - 3;ST-246 Days 11 - 13
4 A Cohort Study of Serological Responses to MVA-BN Smallpox Vaccine (Imvamex®) Administered During a Monkeypox Outbreak in the UK Completed NCT03745131
5 Clinical Protocol to Treat Individuals With Tecovirimat (ST-246) After Exposure to Orthopox Viruses Available NCT02080767 Tecovirimat

Search NIH Clinical Center for Monkeypox

Cochrane evidence based reviews: monkeypox

Genetic Tests for Monkeypox

Anatomical Context for Monkeypox

MalaCards organs/tissues related to Monkeypox:

40
T Cells, Skin, Lymph Node, Spleen, Liver, Monocytes, B Cells

Publications for Monkeypox

Articles related to Monkeypox:

(show top 50) (show all 745)
# Title Authors PMID Year
1
Reemergence of Human Monkeypox and Declining Population Immunity in the Context of Urbanization, Nigeria, 2017-2020. 61
33756100 2021
2
Clinical and epidemiologic findings from enhanced monkeypox surveillance in Tshuapa Province, Democratic Republic of the Congo during 2011-2015. 61
33728469 2021
3
An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications. 61
32882158 2021
4
Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model. 61
33536322 2021
5
Correction for Hutson et al., "Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model". 61
33597175 2021
6
(+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents. 61
33605479 2021
7
Superspreaders: A Lurking Danger in the Community. 61
33448254 2021
8
Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases. 61
33692745 2021
9
A Tale of Two Viruses: Coinfections of Monkeypox and Varicella Zoster Virus in the Democratic Republic of Congo. 61
33289470 2020
10
Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic Orthopoxviruses. 61
33396609 2020
11
Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution. 61
33167496 2020
12
CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector. 61
33168908 2020
13
Identification of protective T-cell antigens for smallpox vaccines. 61
32747299 2020
14
Human and murine memory γδ T cells: Evidence for acquired immune memory in bacterial and viral infections and autoimmunity. 61
32979762 2020
15
Clinical Course and Outcome of Human Monkeypox in Nigeria. 61
32052029 2020
16
Acceptance and willingness to pay for a hypothetical vaccine against monkeypox viral infection among frontline physicians: A cross-sectional study in Indonesia. 61
32861468 2020
17
The Brighton Collaboration standardized template for collection of key information for risk/benefit assessment of a Modified Vaccinia Ankara (MVA) vaccine platform. 61
33077299 2020
18
Exportation of Monkeypox virus from the African continent. 61
32880628 2020
19
Modelling human-to-human transmission of monkeypox. 61
33012864 2020
20
Structural insight into tanapoxvirus-mediated inhibition of apoptosis. 61
32412687 2020
21
Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model. 61
32759969 2020
22
Imported Monkeypox, Singapore. 61
32338590 2020
23
Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading. 61
32745153 2020
24
Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus. 61
32741672 2020
25
Human monkeypox - After 40 years, an unintended consequence of smallpox eradication. 61
32417140 2020
26
Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity. 61
32341480 2020
27
IMVAMUNE® and ACAM2000® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog Model. 61
32698399 2020
28
Comparison of Multiplexed Immunofluorescence Imaging to Chromogenic Immunohistochemistry of Skin Biomarkers in Response to Monkeypox Virus Infection. 61
32717786 2020
29
An Adult Patient with Suspected of Monkeypox Infection Differential Diagnosed to Chickenpox. 61
33704232 2020
30
An adult patient with suspected of monkeypox infection differential diagnosed to chickenpox. 61
32874456 2020
31
Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread. 61
32629851 2020
32
Confidence in managing human monkeypox cases in Asia: A cross-sectional survey among general practitioners in Indonesia. 61
32194068 2020
33
Importance of epidemiological research of monkeypox: is incidence increasing? 61
32096659 2020
34
Human-to-Human Transmission of Monkeypox Virus, United Kingdom, October 2018. 61
32023204 2020
35
Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses. 61
32320436 2020
36
Identification and Whole-Genome Sequencing of a Monkeypox Virus Strain Isolated in Israel. 61
32139560 2020
37
Monitoring healthcare professionals after monkeypox exposure: Experience from the first case imported to Asia. 61
31915078 2020
38
Knowledge of human monkeypox viral infection among general practitioners: a cross-sectional study in Indonesia. 61
32202967 2020
39
Monkeypox Rash Severity and Animal Exposures in the Democratic Republic of the Congo. 61
31875271 2020
40
Repair of a previously uncharacterized second host-range gene contributes to full replication of modified vaccinia virus Ankara (MVA) in human cells. 61
32019881 2020
41
Use of Surveillance Outbreak Response Management and Analysis System for Human Monkeypox Outbreak, Nigeria, 2017-2019. 61
31961314 2020
42
Do Monkeypox Exposures Vary by Ethnicity? Comparison of Aka and Bantu Suspected Monkeypox Cases. 61
31769405 2020
43
Assessment of media reportage of monkeypox in southern Nigeria. 61
32000354 2020
44
Attitudes, practices, and zoonoses awareness of community members involved in the bushmeat trade near Murchison Falls National Park, northern Uganda. 61
32986741 2020
45
A game-theoretic model of Monkeypox to assess vaccination strategies. 61
32607280 2020
46
Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity. 61
32390964 2020
47
A Case Report of Monkeypox in a 4-Year-Old Boy from the DR Congo: Challenges of Diagnosis and Management. 61
32328334 2020
48
Asymptomatic Orthopoxvirus Circulation in Humans in the Wake of a Monkeypox Outbreak among Chimpanzees in Cameroon. 61
31769389 2020
49
Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. 61
31677948 2020
50
Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox. 61
31593747 2020

Variations for Monkeypox

Expression for Monkeypox

Search GEO for disease gene expression data for Monkeypox.

Pathways for Monkeypox

Pathways related to Monkeypox according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 KLRK1 IRF3 IFNA1 CYB5R3 CD8A CD55
2 12.33 IRF3 IFNA1 CD8A CD46
3
Show member pathways
11.91 KLRC3 IFNA1 CD8A CD55 CD4 C4A
4
Show member pathways
11.85 CD55 CD46 C4B C4A C3
5 11.74 KLRK1 CD8A CD4
6
Show member pathways
11.72 CD55 CD46 C4B C4A C3
7 11.65 CD8A CD55 CD4
8 11.62 C4B C4A C3
9
Show member pathways
11.58 CD55 C4B C4A C3
10 11.52 CD55 CD46 C4B C4A C3
11 11.51 KLRK1 CD8A CD4
12 11.5 IRF3 C4B C4A C3

GO Terms for Monkeypox

Cellular components related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 KLRK1 CD55 CD46 CD4 C3

Biological processes related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.87 KLRK1 IRF3 CD55 CD46 C4B C4A
2 adaptive immune response GO:0002250 9.77 KLRK1 IFNA1 CD8A CD46 CD4
3 complement activation, classical pathway GO:0006958 9.65 CD55 CD46 C4B C4A C3
4 complement activation GO:0006956 9.61 C4B C4A C3
5 regulation of complement activation GO:0030449 9.55 CD55 CD46 C4B C4A C3
6 T cell mediated immunity GO:0002456 9.4 CD8A CD46
7 immune system process GO:0002376 9.28 KLRK1 IRF3 CD8A CD55 CD46 CD4
8 positive regulation of apoptotic cell clearance GO:2000427 9.13 C4B C4A C3

Molecular functions related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 CD55 CD46 CD4
2 endopeptidase inhibitor activity GO:0004866 8.8 C4B C4A C3

Sources for Monkeypox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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