MCID: MNK002
MIFTS: 40

Monkeypox

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Monkeypox

MalaCards integrated aliases for Monkeypox:

Name: Monkeypox 12 54 3 45 15 74
Monkeypox Virus Infections 44 74
Monkeypox Virus Infection 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3292
ICD9CM 36 059.01
MeSH 45 D045908
NCIt 51 C128421
SNOMED-CT 69 25157001
ICD10 34 B04

Summaries for Monkeypox

Disease Ontology : 12 A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has material basis in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.

MalaCards based summary : Monkeypox, also known as monkeypox virus infections, is related to variola major and smallpox, and has symptoms including fever and pruritus. An important gene associated with Monkeypox is SPICE1 (Spindle And Centriole Associated Protein 1), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

MedlinePlus : 44 Monkeypox is a rare viral disease. It occurs mostly in central and western Africa. Wild rodents and squirrels carry it, but it is called monkeypox because scientists saw it first in lab monkeys. In 2003, it was reported in prairie dogs and humans in the U.S. Centers for Disease Control and Prevention

CDC : 3 Monkeypox was first discovered in 1958 when two outbreaks of a pox-like disease occurred in colonies of monkeys kept for research, hence the name ‘monkeypox.’ The first human case of monkeypox was recorded in 1970 in the Democratic Republic of Congo during a period of intensified effort to eliminate smallpox. Since then monkeypox has been reported in humans in other central and western African countries.

Wikipedia : 77 Monkeypox is an infectious disease caused by the monkeypox virus that can occur in certain animals... more...

Related Diseases for Monkeypox

Diseases related to Monkeypox via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 variola major 10.8
2 smallpox 10.8
3 vaccinia 10.7
4 cowpox 10.5
5 chickenpox 10.4
6 severe acute respiratory syndrome 10.2
7 bacterial sepsis 10.1
8 pulmonary alveolar microlithiasis 10.0
9 west nile virus 10.0
10 exanthem 10.0
11 influenza 10.0
12 yellow fever 10.0
13 immunodeficiency due to a late component of complement deficiency 9.7 C6 C8A

Graphical network of the top 20 diseases related to Monkeypox:



Diseases related to Monkeypox

Symptoms & Phenotypes for Monkeypox

UMLS symptoms related to Monkeypox:


fever, pruritus

GenomeRNAi Phenotypes related to Monkeypox according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 8.92 BCAM C6
2 Decreased homologous recombination repair frequency GR00151-A-2 8.92 BCAM C6

Drugs & Therapeutics for Monkeypox

Drugs for Monkeypox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3,Phase 2,Phase 1
2 Immunologic Factors Phase 3,Phase 2
3 Antibodies
4 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Completed NCT01143181 Phase 2, Phase 3 CMX001
2 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
3 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
4 Phase I Trial of an Investigational Small Pox Medication Completed NCT00728689 Phase 1 ST-246 Days 1 - 3;ST-246 Days 11 - 13
5 SIGA-246 to Treat Smallpox Withdrawn NCT00303225 Phase 1 Vaccine: SIGA-246
6 Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure Available NCT02080767 Tecovirimat
7 Cohort Study of Healthcare Workers Receiving Imvanex® Enrolling by invitation NCT03745131

Search NIH Clinical Center for Monkeypox

Cochrane evidence based reviews: monkeypox

Genetic Tests for Monkeypox

Anatomical Context for Monkeypox

MalaCards organs/tissues related to Monkeypox:

42
Skin, Lymph Node, T Cells, Liver, Spleen

Publications for Monkeypox

Articles related to Monkeypox:

(show top 50) (show all 332)
# Title Authors Year
1
The 2017 human monkeypox outbreak in Nigeria-Report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria. ( 30995249 )
2019
2
Human Monkeypox: Epidemiologic and Clinical Characteristics, Diagnosis, and Prevention. ( 30981594 )
2019
3
Molecular Evidence of Human Monkeypox Virus Infection, Sierra Leone. ( 30900976 )
2019
4
Diagnosis of Imported Monkeypox, Israel, 2018. ( 30848724 )
2019
5
Human Monkeypox in Sierra Leone after 44-Year Absence of Reported Cases. ( 30753125 )
2019
6
Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. ( 30666937 )
2019
7
Monkeypox Transmission among International Travelers-Serious Monkey Business? ( 30657959 )
2019
8
Monkeypox virus phylogenetic similarities between a human case detected in Cameroon in 2018 and the 2017-2018 outbreak in Nigeria. ( 30634001 )
2019
9
Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. ( 30625020 )
2019
10
Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. ( 30453097 )
2019
11
Vaccinating against monkeypox in the Democratic Republic of the Congo. ( 30445121 )
2019
12
A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. ( 30357851 )
2019
13
Sounding the alarm: Defining thresholds to trigger a public health response to monkeypox. ( 30571693 )
2018
14
Monkeypox contacts: a puzzling problem. ( 30264710 )
2018
15
Two cases of monkeypox imported to the United Kingdom, September 2018. ( 30255836 )
2018
16
Notes from the Field: Responding to an Outbreak of Monkeypox Using the One Health Approach - Nigeria, 2017-2018. ( 30235181 )
2018
17
Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. ( 30234087 )
2018
18
Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques. ( 29982575 )
2018
19
Sixty seconds on . . . monkeypox. ( 30279170 )
2018
20
Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease. ( 29927927 )
2018
21
Strengthening of Surveillance during Monkeypox Outbreak, Republic of the Congo, 2017. ( 29774865 )
2018
22
Should we be already worried about Monkeypox? ( 29747868 )
2018
23
Reemergence of Human Monkeypox in Nigeria, 2017. ( 29619921 )
2018
24
Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. ( 29573840 )
2018
25
Evolution of Synonymous Codon Usage Bias in West African and Central African Strains of Monkeypox Virus. ( 29551886 )
2018
26
Emergence of monkeypox in West Africa and Central Africa, 1970–2017. ( 29546750 )
2018
27
Emergence of Monkeypox - West and Central Africa, 1970-2017. ( 29543790 )
2018
28
Ghosts of infections past: using archival samples to understand a century of monkeypox virus prevalence among host communities across space and time. ( 29410823 )
2018
29
Genomic characterisation of human monkeypox virus in Nigeria. ( 29361427 )
2018
30
Evolution of a Disease Surveillance System: An Increase in Reporting of Human Monkeypox Disease in the Democratic Republic of the Congo, 2001-2013. ( 30123790 )
2017
31
A Nosocomial Outbreak of Human Monkeypox in the Central African Republic. ( 29732376 )
2017
32
Presumptive risk factors for monkeypox in rural communities in the Democratic Republic of the Congo. ( 28192435 )
2017
33
A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox. ( 28003603 )
2017
34
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
35
Toward Understanding the Outcomes of Monkeypox Infection in Human Pregnancy. ( 29029238 )
2017
36
Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo. ( 29029147 )
2017
37
Assessing Monkeypox Virus Prevalence in Small Mammals at the Human-Animal Interface in the Democratic Republic of the Congo. ( 28972544 )
2017
38
Varicella Coinfection in Patients with Active Monkeypox in the Democratic Republic of the Congo. ( 28894977 )
2017
39
Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo. ( 28892474 )
2017
40
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.). ( 28827792 )
2017
41
[18F]-Fluorodeoxyglucose Uptake in Lymphoid Tissue Serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Virus Infection. ( 28814515 )
2017
42
Review of poxvirus: emergence of monkeypox. ( 28406414 )
2017
43
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. ( 28331092 )
2017
44
Evaluation of the GeneXpert for Human Monkeypox Diagnosis. ( 27994107 )
2017
45
Using the Ground Squirrel (Marmota bobak) as an Animal Model to Assess Monkeypox Drug Efficacy. ( 25944444 )
2017
46
Human Monkeypox: Current State of Knowledge and Implications for the Future. ( 30270859 )
2016
47
Finishing monkeypox genomes from short reads: assembly analysis and a neural network method. ( 27585810 )
2016
48
Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay. ( 27477914 )
2016
49
Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. ( 27467578 )
2016
50
Emerging diseases-the monkeypox epidemic in the Democratic Republic of the Congo. ( 27404372 )
2016

Variations for Monkeypox

Expression for Monkeypox

Search GEO for disease gene expression data for Monkeypox.

Pathways for Monkeypox

GO Terms for Monkeypox

Cellular components related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.46 BCAM C6 C8A CYB5R3
2 extracellular exosome GO:0070062 9.26 C6 C8A BCAM SPAG9
3 membrane attack complex GO:0005579 8.62 C6 C8A

Biological processes related to Monkeypox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 9.26 C6 C8A
2 regulation of complement activation GO:0030449 9.16 C6 C8A
3 complement activation GO:0006956 8.96 C6 C8A
4 cytolysis GO:0019835 8.62 C8A C6

Sources for Monkeypox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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