MCID: MNC004
MIFTS: 28

Monoclonal Paraproteinemia

Categories: Metabolic diseases

Aliases & Classifications for Monoclonal Paraproteinemia

MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia 12 15 73
Monoclonal Paraproteinaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2346
ICD9CM 35 273.1
NCIt 50 C35878
SNOMED-CT 68 190812003 267440005
UMLS 73 C0026471

Summaries for Monoclonal Paraproteinemia

MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to systemic lupus erythematosus and selective igg deficiency disease. An important gene associated with Monoclonal Paraproteinemia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Monoclonal Paraproteinemia

Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 27.5 CD40LG CD79A MPO PRTN3 VWF
2 selective igg deficiency disease 10.8 CD40LG CD79A
3 c1q nephropathy 10.8 CD40LG CD79A
4 meningovascular neurosyphilis 10.8 CD40LG CD79A
5 alpha chain disease 10.8 CD40LG CD79A
6 brill-zinsser disease 10.8 CD40LG CD79A
7 exudative glomerulonephritis 10.8 CD40LG CD79A
8 cork-handlers' disease 10.8 CD40LG CD79A
9 salpingo-oophoritis 10.8 CD40LG CD79A
10 early yaws 10.8 CD40LG CD79A
11 ventilation pneumonitis 10.8 CD40LG CD79A
12 chronic interstitial cystitis 10.8 CD40LG CD79A
13 axillary adenitis 10.8 CD40LG CD79A
14 cryofibrinogenemia 10.8 CD40LG CD79A
15 trichostrongyloidiasis 10.8 CD40LG CD79A
16 subacute bacterial endocarditis 10.8 CD40LG CD79A
17 heterophyiasis 10.8 CD40LG CD79A
18 immunoglobulin g deficiency 10.8 CD40LG CD79A
19 transient hypogammaglobulinemia of infancy 10.8 CD40LG CD79A
20 hyperglobulinemic purpura 10.8 CD40LG CD79A
21 gastroduodenitis 10.8 CD40LG CD79A
22 bacterial conjunctivitis 10.8 CD40LG CD79A
23 ophthalmia neonatorum 10.8 CD40LG CD79A
24 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
25 parotid disease 10.8 CD40LG CD79A
26 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
27 geniculate herpes zoster 10.8 CD40LG CD79A
28 erythema elevatum diutinum 10.8 CD40LG CD79A
29 sporotrichosis 10.8 CD40LG CD79A
30 fallopian tube disease 10.8 CD40LG CD79A
31 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
32 congenital syphilis 10.8 CD40LG CD79A
33 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
34 salpingitis 10.8 CD40LG CD79A
35 ocular toxoplasmosis 10.8 CD40LG CD79A
36 dysgammaglobulinemia 10.8 CD40LG CD79A
37 congenital hypogammaglobulinemia 10.8 CD40LG CD79A
38 acute maxillary sinusitis 10.8 CD40LG CD79A
39 chronic polyneuropathy 10.8 CD40LG CD79A
40 spinocerebellar ataxia, autosomal recessive 10 10.8 CD40LG CD79A
41 parasitic ichthyosporea infectious disease 10.8 CD40LG CD79A
42 cd40 ligand deficiency 10.8 CD40LG CD79A
43 rhinosporidiosis 10.8 CD40LG CD79A
44 secondary syphilis 10.8 CD40LG CD79A
45 yellow nail syndrome 10.8 CD40LG CD79A
46 congenital toxoplasmosis 10.7 CD40LG CD79A
47 chorioretinitis 10.7 CD40LG CD79A
48 asymptomatic neurosyphilis 10.7 CD40LG CD79A
49 urethritis 10.7 CD40LG CD79A
50 diffuse glomerulonephritis 10.7 CD40LG CD79A

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Iron Deficiency Anemia
Osteoporosis Plasma Cell Neoplasm

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:



Diseases related to Monoclonal Paraproteinemia

Symptoms & Phenotypes for Monoclonal Paraproteinemia

GenomeRNAi Phenotypes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.96 MPO MYD88 PLK1 VWF CD79A
2 Decreased shRNA abundance GR00251-A-2 9.96 CD79A MPO MYD88 PLK1 VWF
3 Reduced mammosphere formation GR00396-S 9.1 HSP90AA1 MYD88 PLK1 PRTN3 CD27 CD79A

MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CD79A HSP90AA1 MYD88 PLK1 PRTN3 VWF
2 hematopoietic system MP:0005397 9.5 CD40LG CD79A MPO MYD88 PRTN3 VWF
3 immune system MP:0005387 9.23 CD79A HSP90AA1 MPO MYD88 PRTN3 VWF

Drugs & Therapeutics for Monoclonal Paraproteinemia

Search Clinical Trials , NIH Clinical Center for Monoclonal Paraproteinemia

Genetic Tests for Monoclonal Paraproteinemia

Anatomical Context for Monoclonal Paraproteinemia

Publications for Monoclonal Paraproteinemia

Articles related to Monoclonal Paraproteinemia:

# Title Authors Year
1
Spurious hypophosphatemia associated with monoclonal paraproteinemia. ( 21719426 )
2012
2
Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. ( 17291771 )
2008
3
Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. ( 8489339 )
1993
4
Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. ( 3587628 )
1987
5
An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. ( 3030245 )
1987
6
Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. ( 7294627 )
1981

Variations for Monoclonal Paraproteinemia

Expression for Monoclonal Paraproteinemia

Search GEO for disease gene expression data for Monoclonal Paraproteinemia.

Pathways for Monoclonal Paraproteinemia

Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CD27 CD40LG CD79A HSP90AA1 MPO MYD88
2
Show member pathways
12.21 CD27 CD40LG HSP90AA1 MYD88 PRTN3 VWF
3 11.97 CD40LG CD79A MPO MYD88
4 11.01 CD40LG MYD88
5 10.82 CD40LG CD79A

GO Terms for Monoclonal Paraproteinemia

Cellular components related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD27 CD40LG CD79A
2 extracellular region GO:0005576 9.1 CD27 CD40LG HSP90AA1 MPO PRTN3 VWF

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.54 CD27 CD79A MYD88
2 response to lipopolysaccharide GO:0032496 9.43 CD27 MPO MYD88
3 B cell proliferation GO:0042100 9.32 CD40LG CD79A
4 negative regulation of growth of symbiont in host GO:0044130 9.16 MPO MYD88
5 negative regulation of apoptotic process GO:0043066 9.02 CD27 CD40LG MPO MYD88 PLK1
6 immunoglobulin mediated immune response GO:0016064 8.96 CD27 MYD88

Sources for Monoclonal Paraproteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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