Monoclonal Paraproteinemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Monoclonal Paraproteinemia

MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia ¹² ¹⁵ ⁷³

Monoclonal Paraproteinaemia ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2346

ICD9CM ³⁵ 273.1

NCIt ⁵⁰ C35878

SNOMED-CT ⁶⁸ 190812003 267440005

UMLS ⁷³ C0026471

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Summaries for Monoclonal Paraproteinemia

MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to systemic lupus erythematosus and selective igg deficiency disease. An important gene associated with Monoclonal Paraproteinemia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

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Related Diseases for Monoclonal Paraproteinemia

Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)

#	Related Disease	Score	Top Affiliating Genes
1	systemic lupus erythematosus	27.5	CD40LG CD79A MPO PRTN3 VWF
2	selective igg deficiency disease	10.8	CD40LG CD79A
3	c1q nephropathy	10.8	CD40LG CD79A
4	meningovascular neurosyphilis	10.8	CD40LG CD79A
5	alpha chain disease	10.8	CD40LG CD79A
6	brill-zinsser disease	10.8	CD40LG CD79A
7	exudative glomerulonephritis	10.8	CD40LG CD79A
8	cork-handlers' disease	10.8	CD40LG CD79A
9	salpingo-oophoritis	10.8	CD40LG CD79A
10	early yaws	10.8	CD40LG CD79A
11	ventilation pneumonitis	10.8	CD40LG CD79A
12	chronic interstitial cystitis	10.8	CD40LG CD79A
13	axillary adenitis	10.8	CD40LG CD79A
14	cryofibrinogenemia	10.8	CD40LG CD79A
15	trichostrongyloidiasis	10.8	CD40LG CD79A
16	subacute bacterial endocarditis	10.8	CD40LG CD79A
17	heterophyiasis	10.8	CD40LG CD79A
18	immunoglobulin g deficiency	10.8	CD40LG CD79A
19	transient hypogammaglobulinemia of infancy	10.8	CD40LG CD79A
20	hyperglobulinemic purpura	10.8	CD40LG CD79A
21	gastroduodenitis	10.8	CD40LG CD79A
22	bacterial conjunctivitis	10.8	CD40LG CD79A
23	ophthalmia neonatorum	10.8	CD40LG CD79A
24	immunoglobulin a deficiency 1	10.8	CD40LG CD79A
25	parotid disease	10.8	CD40LG CD79A
26	selective immunoglobulin deficiency disease	10.8	CD40LG CD79A
27	geniculate herpes zoster	10.8	CD40LG CD79A
28	erythema elevatum diutinum	10.8	CD40LG CD79A
29	sporotrichosis	10.8	CD40LG CD79A
30	fallopian tube disease	10.8	CD40LG CD79A
31	hyperimmunoglobulin syndrome	10.8	CD40LG CD79A
32	congenital syphilis	10.8	CD40LG CD79A
33	polyclonal hypergammaglobulinemia	10.8	CD40LG CD79A
34	salpingitis	10.8	CD40LG CD79A
35	ocular toxoplasmosis	10.8	CD40LG CD79A
36	dysgammaglobulinemia	10.8	CD40LG CD79A
37	congenital hypogammaglobulinemia	10.8	CD40LG CD79A
38	acute maxillary sinusitis	10.8	CD40LG CD79A
39	chronic polyneuropathy	10.8	CD40LG CD79A
40	spinocerebellar ataxia, autosomal recessive 10	10.8	CD40LG CD79A
41	parasitic ichthyosporea infectious disease	10.8	CD40LG CD79A
42	cd40 ligand deficiency	10.8	CD40LG CD79A
43	rhinosporidiosis	10.8	CD40LG CD79A
44	secondary syphilis	10.8	CD40LG CD79A
45	yellow nail syndrome	10.8	CD40LG CD79A
46	congenital toxoplasmosis	10.7	CD40LG CD79A
47	chorioretinitis	10.7	CD40LG CD79A
48	asymptomatic neurosyphilis	10.7	CD40LG CD79A
49	urethritis	10.7	CD40LG CD79A
50	diffuse glomerulonephritis	10.7	CD40LG CD79A

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):

Acute Cystitis	Acute Kidney Failure
Chronic Kidney Failure	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hypertension, Essential	Iron Deficiency Anemia
Osteoporosis	Plasma Cell Neoplasm

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:

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Symptoms & Phenotypes for Monoclonal Paraproteinemia

GenomeRNAi Phenotypes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance	GR00251-A-1	9.96	MPO MYD88 PLK1 VWF CD79A
2	Decreased shRNA abundance	GR00251-A-2	9.96	CD79A MPO MYD88 PLK1 VWF
3	Reduced mammosphere formation	GR00396-S	9.1	HSP90AA1 MYD88 PLK1 PRTN3 CD27 CD79A

MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.76	CD79A HSP90AA1 MYD88 PLK1 PRTN3 VWF
2	hematopoietic system	MP:0005397	9.5	CD40LG CD79A MPO MYD88 PRTN3 VWF
3	immune system	MP:0005387	9.23	CD79A HSP90AA1 MPO MYD88 PRTN3 VWF

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Drugs & Therapeutics for Monoclonal Paraproteinemia

Search Clinical Trials , NIH Clinical Center for Monoclonal Paraproteinemia

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Genetic Tests for Monoclonal Paraproteinemia

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Anatomical Context for Monoclonal Paraproteinemia

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Publications for Monoclonal Paraproteinemia

Articles related to Monoclonal Paraproteinemia:

#	Title	Authors	Year
1	Spurious hypophosphatemia associated with monoclonal paraproteinemia. ( 21719426 )	Mao Z....Ong A.C.	2012
2	Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. ( 17291771 )	Vallat J.M....Couratier P.	2008
3	Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. ( 8489339 )	Turbat-Herrera E.A....Herrera G.A.	1993
4	Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. ( 3587628 )	Reid T.L....Horowitz S.A.	1987
5	An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. ( 3030245 )	Zuckerman S.J....Osserman E.F.	1987
6	Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. ( 7294627 )	Ruggles K.H....Massey E.W.	1981

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Genes for Monoclonal Paraproteinemia

Genes related to Monoclonal Paraproteinemia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD40LG	CD40 Ligand	Protein Coding	15.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CD79A	CD79a Molecule	Protein Coding	15.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PLK1	Polo Like Kinase 1	Protein Coding	14.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CD27	CD27 Molecule	Protein Coding	14.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MYD88	Myeloid Differentiation Primary Response 88	Protein Coding	13.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	13.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	MPO	Myeloperoxidase	Protein Coding	13.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	VWF	Von Willebrand Factor	Protein Coding	13.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	PRTN3	Proteinase 3	Protein Coding	3.53	DISEASES inferred ¹⁵

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Variations for Monoclonal Paraproteinemia

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Expression for Monoclonal Paraproteinemia

Search GEO for disease gene expression data for Monoclonal Paraproteinemia.

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Pathways for Monoclonal Paraproteinemia

Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.15	CD27 CD40LG CD79A HSP90AA1 MPO MYD88
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.21	CD27 CD40LG HSP90AA1 MYD88 PRTN3 VWF
3	NF-kappaB Signaling ⁴	11.97	CD40LG CD79A MPO MYD88
4	Malaria ³⁷	11.01	CD40LG MYD88
5	Primary immunodeficiency ³⁷	10.82	CD40LG CD79A

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GO Terms for Monoclonal Paraproteinemia

Cellular components related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.13	CD27 CD40LG CD79A
2	extracellular region	GO:0005576	9.1	CD27 CD40LG HSP90AA1 MPO PRTN3 VWF

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.54	CD27 CD79A MYD88
2	response to lipopolysaccharide	GO:0032496	9.43	CD27 MPO MYD88
3	B cell proliferation	GO:0042100	9.32	CD40LG CD79A
4	negative regulation of growth of symbiont in host	GO:0044130	9.16	MPO MYD88
5	negative regulation of apoptotic process	GO:0043066	9.02	CD27 CD40LG MPO MYD88 PLK1
6	immunoglobulin mediated immune response	GO:0016064	8.96	CD27 MYD88

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