MCID: MNC004
MIFTS: 29

Monoclonal Paraproteinemia

Categories: Metabolic diseases

Aliases & Classifications for Monoclonal Paraproteinemia

MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia 12 15 74
Monoclonal Paraproteinaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2346
ICD9CM 36 273.1
NCIt 51 C35878
UMLS 74 C0026471

Summaries for Monoclonal Paraproteinemia

MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to hypersensitivity reaction type iii disease and anca-associated vasculitis. An important gene associated with Monoclonal Paraproteinemia is PLK1 (Polo Like Kinase 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include breast, myeloid and b cells, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Monoclonal Paraproteinemia

Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 hypersensitivity reaction type iii disease 10.1 HSP90AA1 MPO
2 anca-associated vasculitis 10.1 MPO PRTN3
3 henoch-schoenlein purpura 10.1 HSP90AA1 MPO
4 rapidly progressive glomerulonephritis 10.1 MPO PRTN3
5 diffuse intrinsic pontine glioma 10.1 MTOR PLK1
6 chronic maxillary sinusitis 10.0 MPO PRTN3
7 anterior scleritis 10.0 MPO PRTN3
8 pulmonary hemosiderosis 10.0 MPO PRTN3
9 causalgia 10.0 CD27 PRTN3
10 arteritic anterior ischemic optic neuropathy 10.0 MPO PRTN3
11 kaposiform hemangioendothelioma 10.0 MTOR VWF
12 polyarteritis nodosa 10.0 MPO PRTN3
13 macroglobulinemia 10.0 CD27 MYD88
14 churg-strauss syndrome 10.0 MPO PRTN3
15 complement component 4, partial deficiency of 10.0
16 systemic lupus erythematosus 10.0
17 c1q deficiency 10.0
18 c1 inhibitor deficiency 10.0
19 antiphospholipid syndrome 10.0
20 lupus erythematosus 10.0
21 acquired angioedema 10.0
22 epileptic encephalopathy, childhood-onset 9.9 MPO PRTN3
23 motor neuron disease 9.9
24 hypophosphatemia 9.9
25 peripheral nervous system disease 9.9
26 neuropathy 9.9
27 scleromyxedema 9.9
28 encephalopathy 9.9
29 hypersensitivity vasculitis 9.9 HSP90AA1 MPO PRTN3
30 leukemia, chronic myeloid 9.8 HSP90AA1 MPO PRTN3
31 hemimegalencephaly 9.8 CCND1 MTOR
32 vasculitis 9.8 MPO PRTN3 VWF
33 marginal zone b-cell lymphoma 9.8 CCND1 MYD88
34 myeloma, multiple 9.7 CCND1 CD27 HSP90AA1
35 estrogen-receptor positive breast cancer 9.4 CCND1 MTOR

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Iron Deficiency Anemia
Osteoporosis

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:



Diseases related to Monoclonal Paraproteinemia

Symptoms & Phenotypes for Monoclonal Paraproteinemia

GenomeRNAi Phenotypes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.96 MPO MTOR MYD88 PLK1 VWF
2 Decreased shRNA abundance GR00251-A-2 9.96 MPO MTOR MYD88 PLK1 VWF
3 Reduced mammosphere formation GR00396-S 9.17 CCND1 CD27 HSP90AA1 MTOR MYD88 PLK1

MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CCND1 CD27 HSP90AA1 MTOR MYD88 PLK1
2 hematopoietic system MP:0005397 9.5 CCND1 CD27 MPO MTOR MYD88 PRTN3
3 immune system MP:0005387 9.23 CCND1 CD27 HSP90AA1 MPO MTOR MYD88

Drugs & Therapeutics for Monoclonal Paraproteinemia

Search Clinical Trials , NIH Clinical Center for Monoclonal Paraproteinemia

Genetic Tests for Monoclonal Paraproteinemia

Anatomical Context for Monoclonal Paraproteinemia

MalaCards organs/tissues related to Monoclonal Paraproteinemia:

42
Breast, Myeloid, B Cells

Publications for Monoclonal Paraproteinemia

Articles related to Monoclonal Paraproteinemia:

# Title Authors Year
1
Spurious hypophosphatemia associated with monoclonal paraproteinemia. ( 21719426 )
2012
2
Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. ( 17291771 )
2008
3
Acquired C1q deficiency caused by monoclonal paraproteinaemia. ( 10713650 )
2000
4
Acquired C1 inhibitor deficiency associated with systemic lupus erythematosus, secondary antiphospholipid syndrome and IgM monoclonal paraproteinaemia. ( 10088953 )
1999
5
IgG monoclonal paraproteinaemia and peripheral neuropathy. ( 8381472 )
1993
6
Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. ( 8489339 )
1993
7
Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. ( 3587628 )
1987
8
An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. ( 3030245 )
1987
9
Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. ( 7294627 )
1981
10
Lymphocyte transformation in patients with monoclonal paraproteinaemia. ( 4726917 )
1973

Variations for Monoclonal Paraproteinemia

Expression for Monoclonal Paraproteinemia

Search GEO for disease gene expression data for Monoclonal Paraproteinemia.

Pathways for Monoclonal Paraproteinemia

Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 CCND1 CD27 HSP90AA1 MPO MTOR MYD88
2
Show member pathways
12.98 CCND1 CD27 HSP90AA1 MTOR MYD88
3
Show member pathways
12.59 CCND1 HSP90AA1 MTOR VWF
4
Show member pathways
12.41 CCND1 HSP90AA1 MPO MTOR
5
Show member pathways
12.24 CCND1 HSP90AA1 MTOR
6
Show member pathways
12.21 CCND1 CD27 HSP90AA1 MYD88 PRTN3 VWF
7
Show member pathways
12.04 CCND1 HSP90AA1 MTOR
8
Show member pathways
11.88 CCND1 HSP90AA1 MTOR
9 11.74 CCND1 HSP90AA1 MTOR
10 11.69 CCND1 MTOR PLK1
11 11.32 CCND1 MPO PRTN3
12 11.29 HSP90AA1 PLK1
13 11.28 CCND1 MTOR
14 11.26 CCND1 HSP90AA1
15 11.16 HSP90AA1 MTOR
16
Show member pathways
11.1 HSP90AA1 MTOR
17 11.06 CCND1 PLK1
18 10.95 CCND1 HSP90AA1 MTOR

GO Terms for Monoclonal Paraproteinemia

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.62 CD27 MPO MYD88 PLK1
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 MTOR MYD88
3 positive regulation of protein phosphorylation GO:0001934 9.43 CCND1 HSP90AA1 MTOR
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.4 HSP90AA1 MTOR
5 regulation of cellular response to heat GO:1900034 9.37 HSP90AA1 MTOR
6 negative regulation of growth of symbiont in host GO:0044130 9.16 MPO MYD88
7 immunoglobulin mediated immune response GO:0016064 8.96 CD27 MYD88
8 cytokine-mediated signaling pathway GO:0019221 8.92 CCND1 HSP90AA1 MYD88 PRTN3

Molecular functions related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 HSP90AA1 MTOR MYD88 PLK1 VWF

Sources for Monoclonal Paraproteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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