Monoclonal Paraproteinemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Monoclonal Paraproteinemia

MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia ¹² ¹⁵ ⁷³

Monoclonal Paraproteinaemia ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2346

ICD9CM ³⁵ 273.1

NCIt ⁵⁰ C35878

UMLS ⁷³ C0026471

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Summaries for Monoclonal Paraproteinemia

MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to hypersensitivity reaction type iii disease and diffuse intrinsic pontine glioma. An important gene associated with Monoclonal Paraproteinemia is PLK1 (Polo Like Kinase 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include b cells and myeloid, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

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Related Diseases for Monoclonal Paraproteinemia

Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)

#	Related Disease	Score	Top Affiliating Genes
1	hypersensitivity reaction type iii disease	10.1	HSP90AA1 MPO
2	diffuse intrinsic pontine glioma	10.1	MTOR PLK1
3	anca-associated vasculitis	10.1	MPO PRTN3
4	henoch-schoenlein purpura	10.1	HSP90AA1 MPO
5	rapidly progressive glomerulonephritis	10.0	MPO PRTN3
6	chronic maxillary sinusitis	10.0	MPO PRTN3
7	anterior scleritis	10.0	MPO PRTN3
8	pulmonary hemosiderosis	10.0	MPO PRTN3
9	causalgia	10.0	CD27 PRTN3
10	arteritic anterior ischemic optic neuropathy	10.0	MPO PRTN3
11	kaposiform hemangioendothelioma	10.0	MTOR VWF
12	polyarteritis nodosa	10.0	MPO PRTN3
13	macroglobulinemia	10.0	CD27 MYD88
14	churg-strauss syndrome	10.0	MPO PRTN3
15	complement component 4, partial deficiency of	10.0
16	systemic lupus erythematosus	10.0
17	c1q deficiency	10.0
18	c1 inhibitor deficiency	10.0
19	antiphospholipid syndrome	10.0
20	lupus erythematosus	10.0
21	epileptic encephalopathy, childhood-onset	10.0	MPO PRTN3
22	hypersensitivity vasculitis	9.9	HSP90AA1 MPO PRTN3
23	hypophosphatemia	9.9
24	peripheral nervous system disease	9.9
25	neuropathy	9.9
26	scleromyxedema	9.9
27	encephalopathy	9.9
28	leukemia, chronic myeloid	9.9	HSP90AA1 MPO PRTN3
29	hemimegalencephaly	9.9	CCND1 MTOR
30	vasculitis	9.9	MPO PRTN3 VWF
31	marginal zone b-cell lymphoma	9.8	CCND1 MYD88
32	myeloma, multiple	9.8	CCND1 CD27 HSP90AA1
33	estrogen-receptor positive breast cancer	9.6	CCND1 MTOR

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):

Acute Cystitis	Acute Kidney Failure
Chronic Kidney Failure	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hypertension, Essential	Iron Deficiency Anemia
Osteoporosis	Plasma Cell Neoplasm

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:

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Symptoms & Phenotypes for Monoclonal Paraproteinemia

GenomeRNAi Phenotypes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance	GR00251-A-1	9.96	MPO MTOR MYD88 PLK1 VWF
2	Decreased shRNA abundance	GR00251-A-2	9.96	MPO MTOR MYD88 PLK1 VWF
3	Reduced mammosphere formation	GR00396-S	9.17	CCND1 CD27 HSP90AA1 MTOR MYD88 PLK1

MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.76	CCND1 CD27 HSP90AA1 MTOR MYD88 PLK1
2	hematopoietic system	MP:0005397	9.5	CCND1 CD27 MPO MTOR MYD88 PRTN3
3	immune system	MP:0005387	9.23	CCND1 CD27 HSP90AA1 MPO MTOR MYD88

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Drugs & Therapeutics for Monoclonal Paraproteinemia

Search Clinical Trials , NIH Clinical Center for Monoclonal Paraproteinemia

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Genetic Tests for Monoclonal Paraproteinemia

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Anatomical Context for Monoclonal Paraproteinemia

MalaCards organs/tissues related to Monoclonal Paraproteinemia:

⁴¹

B Cells, Myeloid

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Publications for Monoclonal Paraproteinemia

Articles related to Monoclonal Paraproteinemia:

#	Title	Authors	Year
1	Spurious hypophosphatemia associated with monoclonal paraproteinemia. ( 21719426 )	Mao Z....Ong A.C.	2012
2	Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. ( 17291771 )	Vallat J.M....Couratier P.	2008
3	Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. ( 8489339 )	Turbat-Herrera E.A....Herrera G.A.	1993
4	IgG monoclonal paraproteinaemia and peripheral neuropathy. ( 8381472 )	Bleasel AF...McLeod JG	1993
5	Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. ( 3587628 )	Reid T.L....Horowitz S.A.	1987
6	An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. ( 3030245 )	Zuckerman S.J....Osserman E.F.	1987
7	Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. ( 7294627 )		1981
8	Lymphocyte transformation in patients with monoclonal paraproteinaemia. ( 4726917 )	Campbell AE...McFarlane H	1973

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Genes for Monoclonal Paraproteinemia

Genes related to Monoclonal Paraproteinemia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PLK1	Polo Like Kinase 1	Protein Coding	14.61	DISEASES inferred ¹⁵
2	CD27	CD27 Molecule	Protein Coding	14.52	DISEASES inferred ¹⁵
3	MYD88	MYD88, Innate Immune Signal Transduction Adaptor	Protein Coding	14.3	DISEASES inferred ¹⁵
4	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	13.95	DISEASES inferred ¹⁵
5	MPO	Myeloperoxidase	Protein Coding	13.79	DISEASES inferred ¹⁵
6	VWF	Von Willebrand Factor	Protein Coding	13.59	DISEASES inferred ¹⁵
7	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	13.41	DISEASES inferred ¹⁵
8	CCND1	Cyclin D1	Protein Coding	13.12	DISEASES inferred ¹⁵
9	PRTN3	Proteinase 3	Protein Coding	4.05	DISEASES inferred ¹⁵

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Variations for Monoclonal Paraproteinemia

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Expression for Monoclonal Paraproteinemia

Search GEO for disease gene expression data for Monoclonal Paraproteinemia.

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Pathways for Monoclonal Paraproteinemia

Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.35	CCND1 CD27 HSP90AA1 MPO MTOR MYD88
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	12.98	CCND1 CD27 HSP90AA1 MTOR MYD88
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.6	CCND1 HSP90AA1 MTOR VWF
4	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.41	CCND1 HSP90AA1 MPO MTOR
5	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.24	CCND1 HSP90AA1 MTOR
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.21	CCND1 CD27 HSP90AA1 MYD88 PRTN3 VWF
7	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.04	CCND1 HSP90AA1 MTOR
8	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	11.88	CCND1 HSP90AA1 MTOR
9	AKT Signaling Pathway ⁶⁷	11.74	CCND1 HSP90AA1 MTOR
10	Integrated Breast Cancer Pathway ¹	11.69	CCND1 MTOR PLK1
11	C-MYB transcription factor network ¹	11.32	CCND1 MPO PRTN3
12	Mitotic Roles of Polo Like Kinases ⁶⁴	11.29	HSP90AA1 PLK1
13	Wnt Signaling Pathway Netpath ¹	11.28	CCND1 MTOR
14	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.26	CCND1 HSP90AA1
15	LKB1 signaling events ¹	11.16	HSP90AA1 MTOR
16	HSF1-dependent transactivation ⁶⁶ Show member pathways Attenuation phase ⁶⁶ Viral RNP Complexes in the Host Cell Nucleus ⁶⁶	11.1	HSP90AA1 MTOR
17	FOXM1 transcription factor network ¹	11.06	CCND1 PLK1
18	Regulation of Telomerase ¹	10.95	CCND1 HSP90AA1 MTOR

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GO Terms for Monoclonal Paraproteinemia

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.62	CD27 MPO MYD88 PLK1
2	positive regulation of smooth muscle cell proliferation	GO:0048661	9.43	MTOR MYD88
3	positive regulation of protein phosphorylation	GO:0001934	9.43	CCND1 HSP90AA1 MTOR
4	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.4	HSP90AA1 MTOR
5	regulation of cellular response to heat	GO:1900034	9.37	HSP90AA1 MTOR
6	negative regulation of growth of symbiont in host	GO:0044130	9.16	MPO MYD88
7	immunoglobulin mediated immune response	GO:0016064	8.96	CD27 MYD88
8	cytokine-mediated signaling pathway	GO:0019221	8.92	CCND1 HSP90AA1 MYD88 PRTN3

Molecular functions related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.02	HSP90AA1 MTOR MYD88 PLK1 VWF

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