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MCID: MNC004
MIFTS: 33

Monoclonal Paraproteinemia

Categories: Genetic diseases, Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Monoclonal Paraproteinemia

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MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia 12 15 72
Monoclonal Paraproteinaemia 12

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2346
ICD9CM 35 273.1
NCIt 50 C35878
UMLS 72 C0026471
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Summaries for Monoclonal Paraproteinemia

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MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to vasculitis and systemic lupus erythematosus. An important gene associated with Monoclonal Paraproteinemia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drug Bortezomib has been mentioned in the context of this disorder. Affiliated tissues include lung, bone and tongue, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

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Related Diseases for Monoclonal Paraproteinemia

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Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 vasculitis 28.8 VWF PRTN3 MPO CD40LG
2 systemic lupus erythematosus 28.1 VWF PRTN3 MPO CD40LG
3 lymphoproliferative syndrome 2 10.3 CD40LG CD27
4 sulfamethoxazole allergy 10.3 MPO CD40LG
5 transient hypogammaglobulinemia of infancy 10.3 CD40LG CD27
6 primary thrombocytopenia 10.2 VWF CD40LG
7 marginal zone b-cell lymphoma 10.2 MYD88 CD40LG
8 cryoglobulinemia 10.1 CD40LG CD27
9 complement component 4, partial deficiency of 10.1
10 c1 inhibitor deficiency 10.1
11 hypersensitivity reaction type iii disease 10.1 MPO HSP90AA1
12 anca-associated vasculitis 10.1 PRTN3 MPO
13 henoch-schoenlein purpura 10.1 MPO HSP90AA1
14 b cell deficiency 10.1 CD40LG CD27
15 rapidly progressive glomerulonephritis 10.1 PRTN3 MPO
16 causalgia 10.1 PRTN3 CD27
17 macroglobulinemia 10.1 MYD88 CD40LG CD27
18 anterior scleritis 10.0 PRTN3 MPO
19 peripheral nervous system disease 10.0
20 neuropathy 10.0
21 chronic maxillary sinusitis 10.0 PRTN3 MPO
22 pulmonary hemosiderosis 10.0 PRTN3 MPO
23 arteritic anterior ischemic optic neuropathy 10.0 PRTN3 MPO
24 polyarteritis nodosa 10.0 PRTN3 MPO
25 c1q deficiency 10.0
26 polyneuropathy 10.0
27 angioedema 10.0
28 antiphospholipid syndrome 10.0
29 demyelinating polyneuropathy 10.0
30 lupus erythematosus 10.0
31 chronic inflammatory demyelinating polyneuropathy 10.0
32 churg-strauss syndrome 10.0 PRTN3 MPO
33 diffuse intrinsic pontine glioma 10.0 PLK1 MTOR
34 epileptic encephalopathy, childhood-onset 9.9 PRTN3 MPO
35 immune deficiency disease 9.9
36 hypophosphatemia 9.9
37 visual epilepsy 9.9
38 poems syndrome 9.9
39 motor neuron disease 9.9
40 polyclonal hypergammaglobulinemia 9.9
41 polyradiculoneuropathy 9.9
42 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
43 monoclonal gammopathy of uncertain significance 9.9
44 scleromyxedema 9.9
45 encephalopathy 9.9
46 seizure disorder 9.9
47 glomerulonephritis 9.8 PRTN3 MPO CD40LG
48 kaposiform hemangioendothelioma 9.7 VWF MTOR
49 hypersensitivity vasculitis 9.7 PRTN3 MPO HSP90AA1
50 leukemia, chronic myeloid 9.6 PRTN3 MPO HSP90AA1

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Iron Deficiency Anemia Osteoporosis

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:



Diseases related to Monoclonal Paraproteinemia
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Symptoms & Phenotypes for Monoclonal Paraproteinemia

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GenomeRNAi Phenotypes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.96 MPO MTOR MYD88 PLK1 VWF
2 Decreased shRNA abundance GR00251-A-2 9.96 MPO MTOR MYD88 PLK1 VWF
3 Reduced mammosphere formation GR00396-S 9.1 CD27 HSP90AA1 MTOR MYD88 PLK1 PRTN3

MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CD27 CD40LG HSP90AA1 MTOR MYD88 PLK1
2 hematopoietic system MP:0005397 9.5 CD27 CD40LG MPO MTOR MYD88 PRTN3
3 immune system MP:0005387 9.23 CD27 CD40LG HSP90AA1 MPO MTOR MYD88
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Drugs & Therapeutics for Monoclonal Paraproteinemia

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Drugs for Monoclonal Paraproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bortezomib Approved, Investigational Phase 1, Phase 2 179324-69-7 93860 387447

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I/II Trial of Autologous Peripheral Blood Progenitor Cell Transplantation With VELCADE Maintenance as Treatment for Intermediate- and Advanced-Stage Multiple Myeloma Completed NCT00084747 Phase 1, Phase 2 bortezomib

Search NIH Clinical Center for Monoclonal Paraproteinemia

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Genetic Tests for Monoclonal Paraproteinemia

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Anatomical Context for Monoclonal Paraproteinemia

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MalaCards organs/tissues related to Monoclonal Paraproteinemia:

41
Lung, Bone, Tongue, B Cells, Myeloid
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Publications for Monoclonal Paraproteinemia

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Articles related to Monoclonal Paraproteinemia:

(show all 44)
# Title Authors PMID Year
1
IgM myeloma: A multicenter retrospective study of 134 patients. 38
28383205 2017
2
Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma. 38
27582537 2016
3
A Case of Autoimmune Polyglandular Syndrome .ype 2 Associated with Atypical Form of Scleromyxedema. 38
28446858 2016
4
Persistence of renal function in a patient diagnosed with concurrent amyloid amyloidosis and immunoglobulin light chain amyloidosis. 38
30375826 2016
5
MYD88 (L265P) somatic mutation in marginal zone B-cell lymphoma. 38
25723115 2015
6
Spurious hypophosphatemia associated with monoclonal paraproteinemia. 38
21719426 2012
7
Emerging drugs for Waldenström's macroglobulinemia. 38
21352069 2011
8
Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. 38
17291771 2008
9
Solitary plasmacytoma of bone in two successfully treated cats. 38
16887373 2007
10
Necrobiotic xanthogranuloma-rapid progression under treatment with melphalan. 38
16172046 2005
11
Carbamazepine induced transient monoclonal gammopathy and immunodeficiency. 38
15087096 2004
12
Scleromyxedema revisited. 38
12581140 2003
13
Primary central nervous system lymphoma with paraproteinemia. 38
11750007 2001
14
Idiopathic AL amyloidosis and biclonal paraproteinemia: a case report and review of the literature. 38
11676298 2001
15
[Association between motoneuron disease and Waldenström macroglobulinemia]. 38
11552308 2001
16
Scleromyxedema with dermato-neuro syndrome. 38
10767707 2000
17
Acquired C1q deficiency caused by monoclonal paraproteinaemia. 38
10713650 2000
18
Acquired C1 inhibitor deficiency associated with systemic lupus erythematosus, secondary antiphospholipid syndrome and IgM monoclonal paraproteinaemia. 38
10088953 1999
19
[Amyloidosis of the tongue as a possible diagnostic manifestation of plasmacytoma]. 38
10077969 1999
20
[Primary pulmonary plasmacytoma. Case report of a rare lung tumor]. 38
9651571 1998
21
Morphometric evaluation of paraneoplastic neuropathies associated with carcinomas, lymphomas, and dysproteinemias. 38
10970126 1998
22
Lymphoproliferative disorders and motor neuron disease: an update. 38
9191785 1997
23
[Chronic edema, monoclonal dysglobulinemia and profuse telangiectasia: a distinct entity?]. 38
9740872 1997
24
Erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with intermittent plasma exchange. 38
8915315 1996
25
[Late-onset multiple sclerosis and serum monoclonal gammopathy: an incidental association?]. 38
8991179 1996
26
[The spectrum of diseases associated with antineutrophil cytoplasmic antibodies]. 38
7712518 1995
27
Effectiveness of high-dose intravenous gamma globulin therapy in acquired von Willebrand's disease. 38
7975445 1994
28
Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. 38
8489339 1993
29
A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents. 38
8457454 1993
30
IgG monoclonal paraproteinaemia and peripheral neuropathy. 38
8381472 1993
31
The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings. 38
1660064 1991
32
Cranial magnetic resonance imaging in chronic demyelinating polyneuropathy. 38
2123236 1990
33
[Hemorheological and coagulation aspects in plasmacytoma]. 38
2624709 1989
34
The clinical and cellular aspects of Waldenström's macroglobulinaemia. 38
3138961 1988
35
Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. 38
3587628 1987
36
An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. 38
3030245 1987
37
Proximal motor neuropathy, dermato-endocrine syndrome, and IgG kappa paraproteinemia. 38
3089203 1986
38
Neuropathy and motor neuron syndromes associated with plasma cell disease. 38
6475486 1984
39
Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy. 38
7067074 1982
40
Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. 38
7294627 1981
41
Identification of the paraproteins and clinical significance of more than one paraprotein and clinical significance of more than one paraprotein in serum of 56 patients. 38
109473 1979
42
Transient warm autoimmune hemolytic anemia and cryoglobulinemia associated with seminoma. 38
906560 1977
43
Lymphocyte transformation in patients with monoclonal paraproteinaemia. 38
4726917 1973
44
[Culture in vitro of lymphocytes in 14 cases of monoclonal paraproteinemia]. 38
4099297 1969
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Variations for Monoclonal Paraproteinemia

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Expression for Monoclonal Paraproteinemia

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Search GEO for disease gene expression data for Monoclonal Paraproteinemia.
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Pathways for Monoclonal Paraproteinemia

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Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.15 VWF PRTN3 MYD88 MTOR MPO HSP90AA1
2
Akt Signaling 64
Show member pathways
 12.7 MYD88 MTOR HSP90AA1 CD40LG CD27
3
Cytokine Signaling in Immune system 66
Show member pathways
 12.21 VWF PRTN3 MYD88 HSP90AA1 CD40LG CD27
4
NF-kappaB Signaling 4
12.15 MYD88 MPO CD40LG
5
IL4-mediated signaling events 1
11.29 MTOR CD40LG
6
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 65
11.24 CD40LG CD27
7
Mitotic Roles of Polo Like Kinases 64
11.16 PLK1 HSP90AA1
8
B Cell Development Pathways 65
11.13 CD40LG CD27
9
Malaria 37
11.06 MYD88 CD40LG
10
LKB1 signaling events 1
10.94 MTOR HSP90AA1
11
HSF1-dependent transactivation 66
Show member pathways
 10.85 MTOR HSP90AA1
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GO Terms for Monoclonal Paraproteinemia

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Cellular components related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 VWF PRTN3 MPO HSP90AA1 CD40LG CD27

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 PRTN3 MYD88 HSP90AA1
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.4 MYD88 MTOR
3 regulation of cellular response to heat GO:1900034 9.32 MTOR HSP90AA1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 MTOR HSP90AA1
5 negative regulation of growth of symbiont in host GO:0044130 9.16 MYD88 MPO
6 negative regulation of apoptotic process GO:0043066 9.02 PLK1 MYD88 MPO CD40LG CD27
7 immunoglobulin mediated immune response GO:0016064 8.96 MYD88 CD27

Molecular functions related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 VWF PLK1 MYD88 MTOR HSP90AA1
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Sources for Monoclonal Paraproteinemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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