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MCID: MNC004
MIFTS: 34

Monoclonal Paraproteinemia

Categories: Genetic diseases, Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Monoclonal Paraproteinemia

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MalaCards integrated aliases for Monoclonal Paraproteinemia:

Name: Monoclonal Paraproteinemia 12 15 71
Monoclonal Paraproteinaemia 12

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2346
ICD9CM 34 273.1
NCIt 49 C35878
UMLS 71 C0026471
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Summaries for Monoclonal Paraproteinemia

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MalaCards based summary : Monoclonal Paraproteinemia, also known as monoclonal paraproteinaemia, is related to immune deficiency disease and monoclonal gammopathy of uncertain significance. An important gene associated with Monoclonal Paraproteinemia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. The drug Bortezomib has been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Monoclonal Paraproteinemia

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Diseases related to Monoclonal Paraproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 immune deficiency disease 29.3 CD79A CD40LG CD38
2 monoclonal gammopathy of uncertain significance 29.1 SDC1 CD40LG CD38 CD19
3 marginal zone b-cell lymphoma 28.0 PAX5 CD79A CD40LG CD22 CD19
4 plasma cell neoplasm 28.0 SDC1 PAX5 CD79A CD40LG CD38 CD19
5 systemic lupus erythematosus 27.6 SDC1 CD79A CD40LG CD38 CD22 CD19
6 gamma heavy chain disease 10.3 SDC1 CD40LG
7 hemorrhagic fever-renal syndrome 10.2 CD79A CD40LG
8 c1q nephropathy 10.2 CD79A CD40LG
9 hilar lung carcinoma 10.2 CD79A CD40LG
10 lung hilum cancer 10.2 CD79A CD40LG
11 immunoglobulin g deficiency 10.2 CD79A CD40LG
12 cryofibrinogenemia 10.2 CD79A CD40LG
13 heavy chain disease 10.2 CD79A CD40LG
14 ocular toxoplasmosis 10.2 CD79A CD40LG
15 tracheal lymphoma 10.2 SDC1 PAX5
16 congenital syphilis 10.2 CD79A CD40LG
17 syphilis 10.2 CD79A CD40LG
18 secondary syphilis 10.2 CD79A CD40LG
19 infected hydrocele 10.2 SDC1 CD79A
20 immunodeficiency with hyper-igm, type 1 10.2 CD79A CD40LG
21 immunoglobulin a deficiency 1 10.2 CD79A CD40LG
22 pustulosis palmaris et plantaris 10.2 CD79A CD40LG
23 sporotrichosis 10.2 CD79A CD40LG
24 parotitis 10.2 CD79A CD40LG
25 calciphylaxis 10.2 CD79A CD40LG
26 pleural empyema 10.2 CD79A CD40LG
27 dysgammaglobulinemia 10.2 CD79A CD40LG
28 persistent generalized lymphadenopathy 10.2 CD79A CD40LG
29 strongyloidiasis 10.2 CD79A CD40LG
30 acute poststreptococcal glomerulonephritis 10.1 CD79A CD40LG
31 congenital toxoplasmosis 10.1 CD79A CD40LG
32 congenital hypogammaglobulinemia 10.1 CD40LG CD19
33 giardiasis 10.1 CD79A CD40LG
34 selective igg deficiency disease 10.1 PAX5 CD79A
35 complement component 4, partial deficiency of 10.1
36 c1 inhibitor deficiency 10.1
37 bone lymphoma 10.1 PAX5 CD79A
38 spherocytosis, type 5 10.1 SDC1 CD38
39 henoch-schoenlein purpura 10.1 CD79A CD40LG
40 transient hypogammaglobulinemia of infancy 10.1 CD40LG CD19
41 transient hypogammaglobulinemia 10.1 CD40LG CD19
42 purpura 10.1 CD79A CD40LG
43 lung lymphoma 10.1 PAX5 CD79A
44 mesangial proliferative glomerulonephritis 10.1 CD79A CD40LG
45 mediastinal malignant lymphoma 10.1 PAX5 CD79A
46 keratoconjunctivitis sicca 10.1 CD79A CD40LG
47 mediastinal gray zone lymphoma 10.1 PAX5 CD79A
48 gray zone lymphoma 10.1 PAX5 CD79A
49 amebiasis 10.1 CD79A CD40LG
50 paranasal sinus lymphoma 10.1 PAX5 CD79A

Comorbidity relations with Monoclonal Paraproteinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Iron Deficiency Anemia Osteoporosis
Plasma Cell Neoplasm

Graphical network of the top 20 diseases related to Monoclonal Paraproteinemia:



Diseases related to Monoclonal Paraproteinemia
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Symptoms & Phenotypes for Monoclonal Paraproteinemia

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MGI Mouse Phenotypes related to Monoclonal Paraproteinemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 CD19 CD22 CD38 CD40LG CD79A PAX5
2 hematopoietic system MP:0005397 9.86 CD19 CD22 CD38 CD40LG CD79A PAX5
3 homeostasis/metabolism MP:0005376 9.7 CD19 CD38 CD40LG CD79A PAX5 SDC1
4 immune system MP:0005387 9.5 CD19 CD22 CD38 CD40LG CD79A PAX5
5 neoplasm MP:0002006 8.92 CD19 CD79A PAX5 SDC1
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Drugs & Therapeutics for Monoclonal Paraproteinemia

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Drugs for Monoclonal Paraproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bortezomib Approved, Investigational Phase 1, Phase 2 179324-69-7 387447 93860

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I/II Trial of Autologous Peripheral Blood Progenitor Cell Transplantation With VELCADE Maintenance as Treatment for Intermediate- and Advanced-Stage Multiple Myeloma Completed NCT00084747 Phase 1, Phase 2 bortezomib

Search NIH Clinical Center for Monoclonal Paraproteinemia

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Genetic Tests for Monoclonal Paraproteinemia

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Anatomical Context for Monoclonal Paraproteinemia

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MalaCards organs/tissues related to Monoclonal Paraproteinemia:

40
B Cells, Bone, Lung, Myeloid, Bone Marrow, Spinal Cord, T Cells
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Publications for Monoclonal Paraproteinemia

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Articles related to Monoclonal Paraproteinemia:

(show all 45)
# Title Authors PMID Year
1
High-grade nodal marginal zone lymphoma with diffuse bone marrow involvement and IgM-type monoclonal paraproteinemia: a case report and review of the literature. 61
31730683 2019
2
IgM myeloma: A multicenter retrospective study of 134 patients. 61
28383205 2017
3
Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma. 61
27582537 2016
4
A Case of Autoimmune Polyglandular Syndrome .ype 2 Associated with Atypical Form of Scleromyxedema. 61
28446858 2016
5
Persistence of renal function in a patient diagnosed with concurrent amyloid amyloidosis and immunoglobulin light chain amyloidosis. 61
30375826 2016
6
MYD88 (L265P) somatic mutation in marginal zone B-cell lymphoma. 61
25723115 2015
7
Spurious hypophosphatemia associated with monoclonal paraproteinemia. 61
21719426 2012
8
Emerging drugs for Waldenström's macroglobulinemia. 61
21352069 2011
9
Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia. 61
17291771 2008
10
Solitary plasmacytoma of bone in two successfully treated cats. 61
16887373 2007
11
Necrobiotic xanthogranuloma-rapid progression under treatment with melphalan. 61
16172046 2005
12
Carbamazepine induced transient monoclonal gammopathy and immunodeficiency. 61
15087096 2004
13
Scleromyxedema revisited. 61
12581140 2003
14
Primary central nervous system lymphoma with paraproteinemia. 61
11750007 2001
15
Idiopathic AL amyloidosis and biclonal paraproteinemia: a case report and review of the literature. 61
11676298 2001
16
[Association between motoneuron disease and Waldenström macroglobulinemia]. 61
11552308 2001
17
Scleromyxedema with dermato-neuro syndrome. 61
10767707 2000
18
Acquired C1q deficiency caused by monoclonal paraproteinaemia. 61
10713650 2000
19
Acquired C1 inhibitor deficiency associated with systemic lupus erythematosus, secondary antiphospholipid syndrome and IgM monoclonal paraproteinaemia. 61
10088953 1999
20
[Amyloidosis of the tongue as a possible diagnostic manifestation of plasmacytoma]. 61
10077969 1999
21
[Primary pulmonary plasmacytoma. Case report of a rare lung tumor]. 61
9651571 1998
22
Morphometric evaluation of paraneoplastic neuropathies associated with carcinomas, lymphomas, and dysproteinemias. 61
10970126 1998
23
Lymphoproliferative disorders and motor neuron disease: an update. 61
9191785 1997
24
[Chronic edema, monoclonal dysglobulinemia and profuse telangiectasia: a distinct entity?]. 61
9740872 1997
25
Erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with intermittent plasma exchange. 61
8915315 1996
26
[Late-onset multiple sclerosis and serum monoclonal gammopathy: an incidental association?]. 61
8991179 1996
27
[The spectrum of diseases associated with antineutrophil cytoplasmic antibodies]. 61
7712518 1995
28
Effectiveness of high-dose intravenous gamma globulin therapy in acquired von Willebrand's disease. 61
7975445 1994
29
Plasma cell hyperplasia and monoclonal paraproteinemia in human immunodeficiency virus-infected patients. 61
8489339 1993
30
A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents. 61
8457454 1993
31
IgG monoclonal paraproteinaemia and peripheral neuropathy. 61
8381472 1993
32
The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings. 61
1660064 1991
33
Cranial magnetic resonance imaging in chronic demyelinating polyneuropathy. 61
2123236 1990
34
[Hemorheological and coagulation aspects in plasmacytoma]. 61
2624709 1989
35
The clinical and cellular aspects of Waldenström's macroglobulinaemia. 61
3138961 1988
36
Monoclonal paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema. 61
3587628 1987
37
An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. 61
3030245 1987
38
Proximal motor neuropathy, dermato-endocrine syndrome, and IgG kappa paraproteinemia. 61
3089203 1986
39
Neuropathy and motor neuron syndromes associated with plasma cell disease. 61
6475486 1984
40
Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy. 61
7067074 1982
41
Pupil-sparing oculomotor palsy with IgG monoclonal paraproteinemia. 61
7294627 1981
42
Identification of the paraproteins and clinical significance of more than one paraprotein and clinical significance of more than one paraprotein in serum of 56 patients. 61
109473 1979
43
Transient warm autoimmune hemolytic anemia and cryoglobulinemia associated with seminoma. 61
906560 1977
44
Lymphocyte transformation in patients with monoclonal paraproteinaemia. 61
4726917 1973
45
[Culture in vitro of lymphocytes in 14 cases of monoclonal paraproteinemia]. 61
4099297 1969
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Variations for Monoclonal Paraproteinemia

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Expression for Monoclonal Paraproteinemia

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Search GEO for disease gene expression data for Monoclonal Paraproteinemia.
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Pathways for Monoclonal Paraproteinemia

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Pathways related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.2 CD79A CD22 CD19
2
NF-kappaB Signaling 4
12.07 PAX5 CD79A CD40LG CD38 CD19
3
B cell receptor signaling pathway (KEGG) 1
Show member pathways
 12.03 CD79A CD22 CD19
4
Cell adhesion molecules (CAMs) 36
11.78 SDC1 CD40LG CD22
5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.71 CD40LG CD22 CD19
6
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 65
Show member pathways
 11.57 CD79A CD22 CD19
7
Hematopoietic cell lineage 36
11.49 CD38 CD22 CD19
8
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.42 SDC1 CD79A CD38 CD22 CD19
9
Malaria 36
11.18 SDC1 CD40LG
10
Primary immunodeficiency 36
11.01 CD79A CD40LG CD19
11
B Cell Development Pathways 64
10.82 SDC1 PAX5 CD40LG CD38 CD22 CD19
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GO Terms for Monoclonal Paraproteinemia

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Cellular components related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 SDC1 CD40LG CD38 CD22
2 external side of plasma membrane GO:0009897 8.92 SDC1 CD79A CD40LG CD19

Biological processes related to Monoclonal Paraproteinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.33 CD40LG CD22 CD19
2 B cell proliferation GO:0042100 9.32 CD79A CD40LG
3 B cell activation GO:0042113 9.26 CD79A CD22
4 B cell receptor signaling pathway GO:0050853 9.13 CD79A CD38 CD19
5 regulation of B cell receptor signaling pathway GO:0050855 8.62 PAX5 CD19
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Sources for Monoclonal Paraproteinemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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