MCID: MNC022
MIFTS: 17

Monocyte, Dendritic Cell, and Nk Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for Monocyte, Dendritic Cell, and Nk Cell Deficiency

MalaCards integrated aliases for Monocyte, Dendritic Cell, and Nk Cell Deficiency:

Name: Monocyte, Dendritic Cell, and Nk Cell Deficiency 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0111966

Summaries for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Disease Ontology : 12 A combined immunodeficiency characterized by impaired function or reduced numbers of monocytes, dendritic cells, and natural killer (NK) cells.

MalaCards based summary : Monocyte, Dendritic Cell, and Nk Cell Deficiency is related to immunodeficiency 32b and spleen cancer. An important gene associated with Monocyte, Dendritic Cell, and Nk Cell Deficiency is IRF8 (Interferon Regulatory Factor 8), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include monocytes and nk cells, and related phenotypes are immune system and no phenotypic analysis

Related Diseases for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Graphical network of the top 20 diseases related to Monocyte, Dendritic Cell, and Nk Cell Deficiency:



Diseases related to Monocyte, Dendritic Cell, and Nk Cell Deficiency

Symptoms & Phenotypes for Monocyte, Dendritic Cell, and Nk Cell Deficiency

MGI Mouse Phenotypes related to Monocyte, Dendritic Cell, and Nk Cell Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.43 CLEC4C IL3RA IRF8 ITGAX SPI1 SPIC
2 no phenotypic analysis MP:0003012 9.02 CLEC4C IRF8 ITGAX SPI1 SPIC

Drugs & Therapeutics for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Search Clinical Trials , NIH Clinical Center for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Genetic Tests for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Anatomical Context for Monocyte, Dendritic Cell, and Nk Cell Deficiency

MalaCards organs/tissues related to Monocyte, Dendritic Cell, and Nk Cell Deficiency:

40
Monocytes, Nk Cells

Publications for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Variations for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Expression for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Search GEO for disease gene expression data for Monocyte, Dendritic Cell, and Nk Cell Deficiency.

Pathways for Monocyte, Dendritic Cell, and Nk Cell Deficiency

GO Terms for Monocyte, Dendritic Cell, and Nk Cell Deficiency

Cellular components related to Monocyte, Dendritic Cell, and Nk Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 9.26 ITGAX CLEC4C
2 tertiary granule membrane GO:0070821 9.16 ITGAX CLEC4C
3 external side of plasma membrane GO:0009897 9.13 ITGAX IL3RA CD1C
4 ficolin-1-rich granule membrane GO:0101003 8.62 ITGAX CLEC4C

Sources for Monocyte, Dendritic Cell, and Nk Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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