MCID: MNC007
MIFTS: 48

Monocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Monocytic Leukemia

MalaCards integrated aliases for Monocytic Leukemia:

Name: Monocytic Leukemia 12 54 15 70
Monocytic Leukaemia 12 32
M5b Acute Differentiated Monocytic Leukemia 70
Schilling's Leukaemia 12
Schilling's Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8527
ICD9CM 34 206.8
SNOMED-CT 67 188747004
ICD10 32 C93 C93.9 C93.Z
UMLS 70 C0153903 C0598894 C1318544

Summaries for Monocytic Leukemia

Disease Ontology : 12 A myeloid leukemia that is characterized by a dominance of monocytes in the marrow.

MalaCards based summary : Monocytic Leukemia, also known as monocytic leukaemia, is related to acute monoblastic leukemia and leukemia, acute monocytic. An important gene associated with Monocytic Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include myeloid, monocytes and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

Related Diseases for Monocytic Leukemia

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 687)
# Related Disease Score Top Affiliating Genes
1 acute monoblastic leukemia 32.7 KMT2A IL6 CXCL8 CSF2
2 leukemia, acute monocytic 32.6 TNF KMT2A KAT6A IL6 IL1B CXCL8
3 histiocytosis 31.0 TNF IFNG CSF2
4 chronic myelomonocytic leukemia 30.9 KMT2A KAT6A CSF2 CSF1
5 sarcoma 30.4 JUN IL6 CXCL8 CSF2 CASP3
6 purpura 30.4 TNF IL6 IFNG
7 leukemia, acute myeloid 30.3 TNF KMT2A KAT6A JUN ITGAM IL6
8 pancytopenia 30.3 KMT2A IL6 IFNG CSF2 CSF1
9 hypopyon 30.2 TNF IL6 IL1B
10 chickenpox 30.2 TNF IL6 IFNG
11 graft-versus-host disease 30.2 TNF IL6 IL1B IFNG FAS
12 ileus 30.2 TNF IL6 IL1B
13 myelofibrosis 30.1 TNF ITGAM IL1B CXCL8
14 obstructive jaundice 30.1 TNF IL6 CXCL8
15 hemophagocytic lymphohistiocytosis 30.1 TNF IFNG FAS CXCL8
16 thrombocytosis 30.1 IL6 IL1B CSF2
17 herpangina 30.1 TNF IL6 IL1B IFNG
18 human cytomegalovirus infection 30.1 IL6 IL1B FAS CXCL8 CASP3
19 endocarditis 30.1 TNF IL6 IFNG CXCL8
20 respiratory failure 30.1 TNF JUN IL6 IL1B CXCL8
21 exanthem 30.1 TNF IL6 IL1B IFNG CXCL8 CSF2
22 crohn's colitis 30.1 TNF IL1B IFNG CXCL8
23 gastric ulcer 30.0 TNF IL6 IL1B CXCL8
24 gingival overgrowth 30.0 TNF IL6 IFNG CXCL8
25 pertussis 30.0 TNF JUN ITGAM IL6 IL1B CXCL8
26 acute pancreatitis 30.0 TNF IL6 IL1B CXCL8
27 visceral leishmaniasis 30.0 TNF IL1B IFNG CXCL8
28 leukemia, chronic lymphocytic 30.0 TNF KMT2A IL6 FAS CSF2 CASP3
29 t-cell lymphoblastic leukemia/lymphoma 30.0 TNFRSF1A JUN FAS CASP3
30 bone resorption disease 30.0 TNF PPARG IL6 IL1B CSF1
31 urticaria 30.0 TNF IL6 CYSLTR1 CXCL8
32 gingivitis 30.0 TNF IL6 IL1B IFNG CXCL8
33 sarcoidosis 1 30.0 TNF ITGAM IL1B IFNG
34 bone disease 30.0 TNF IL6 IL1B CXCL8 CSF1
35 amyloidosis 29.9 TNFRSF1A TNF IL6 IL1B
36 myeloma, multiple 29.9 TNF JUN IL6 IL1B CXCL8 CSF2
37 neuritis 29.9 TNF IL6 IL1B IFNG CXCL8
38 leishmaniasis 29.9 TNF ITGAM IL6 IL1B IFNG
39 severe congenital neutropenia 29.9 TNF IL1B CXCL8 CSF2 CSF1
40 central nervous system disease 29.8 TNF IL6 IL1B IFNG
41 neutropenia 29.8 TNFRSF1A TNF ITGAM IL6 IL1B CXCL8
42 pheochromocytoma 29.8 TNF JUN IL6 IL1B CASP3
43 essential thrombocythemia 29.8 TNF ITGAM IL6 CXCL8 CSF2
44 toxic shock syndrome 29.8 TNF IL6 IL1B IFNG CXCL8 CD14
45 meningitis 29.7 TNF IL6 IL1B IFNG CXCL8 CSF2
46 dermatitis 29.7 TNF IL6 IL1B IFNG CXCL8 CSF2
47 candidiasis 29.7 TNF IL6 IL1B IFNG CXCL8 CSF2
48 allergic disease 29.7 TNF IL6 IL1B IFNG CXCL8 CSF2
49 adult respiratory distress syndrome 29.7 TNF ITGAM IL6 IL1B CXCL8 CD14
50 aspergillosis 29.6 TNF IL6 IL1B IFNG CXCL8 CSF2

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to Monocytic Leukemia

Symptoms & Phenotypes for Monocytic Leukemia

GenomeRNAi Phenotypes related to Monocytic Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.55 CASP3 CD14 CXCL8 FAS IL1B JUN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.55 CASP3 CD14 CXCL8 FAS IL1B JUN
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.55 JUN
4 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CASP3 CSF2 CXCL8 TNF

MGI Mouse Phenotypes related to Monocytic Leukemia:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.5 CAB39L CASP3 CSF1 CSF2 CYSLTR1 FAS
2 growth/size/body region MP:0005378 10.47 CAB39L CASP3 CD14 CSF1 CSF2 FAS
3 hematopoietic system MP:0005397 10.46 CAB39L CASP3 CD14 CSF1 CSF2 FAS
4 cellular MP:0005384 10.44 CASP3 CSF1 CSF2 CYSLTR1 FAS IFNG
5 immune system MP:0005387 10.44 CASP3 CD14 CSF1 CSF2 CYSLTR1 FAS
6 homeostasis/metabolism MP:0005376 10.42 CASP3 CD14 CSF1 CSF2 FAS IFNG
7 mortality/aging MP:0010768 10.35 CASP3 CD14 CSF1 CSF2 FAS IFNG
8 integument MP:0010771 10.34 CASP3 CSF1 CSF2 FAS IFNG IL1B
9 craniofacial MP:0005382 10.32 CASP3 CSF1 CSF2 FAS IFNG IL1B
10 endocrine/exocrine gland MP:0005379 10.32 CASP3 CSF1 CSF2 FAS IFNG IL6
11 nervous system MP:0003631 10.28 CASP3 CSF1 CSF2 FAS IFNG IL1B
12 liver/biliary system MP:0005370 10.19 CSF1 FAS IFNG IL6 JUN KAT6A
13 muscle MP:0005369 10.11 CASP3 CSF1 FAS IFNG IL6 KMT2A
14 neoplasm MP:0002006 10.09 CSF2 FAS IFNG IL1B IL6 KMT2A
15 limbs/digits/tail MP:0005371 10.05 CSF1 FAS JUN KAT6A KMT2A TNF
16 reproductive system MP:0005389 10 CASP3 CSF1 CSF2 FAS IFNG IL6
17 no phenotypic analysis MP:0003012 9.97 CASP3 CSF1 IFNG JUN KMT2A PPARG
18 renal/urinary system MP:0005367 9.92 CASP3 CSF2 FAS IFNG IL6 KMT2A
19 respiratory system MP:0005388 9.9 CASP3 CD14 CSF1 CSF2 CYSLTR1 FAS
20 skeleton MP:0005390 9.8 CASP3 CD14 CSF1 CSF2 FAS IFNG
21 vision/eye MP:0005391 9.32 CASP3 CSF1 FAS IFNG IL6 JUN

Drugs & Therapeutics for Monocytic Leukemia

Search Clinical Trials , NIH Clinical Center for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

Anatomical Context for Monocytic Leukemia

MalaCards organs/tissues related to Monocytic Leukemia:

40
Myeloid, Monocytes, Endothelial, Skin, Bone Marrow, T Cells, Lymph Node

Publications for Monocytic Leukemia

Articles related to Monocytic Leukemia:

(show top 50) (show all 2305)
# Title Authors PMID Year
1
Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. 61 54
20427734 2010
2
Effect of Sargassum thunbergii on ROS mediated oxidative damage and identification of polyunsaturated fatty acid components. 61 54
20171254 2010
3
The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. 54 61
20438701 2010
4
A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. 54 61
19506293 2009
5
Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway. 54 61
19556303 2009
6
Antiglaucoma drug GLC756 and its effect on cellular cAMP and tumor necrosis factor alpha release in vitro of activated human monocytic leukemia cells. 61 54
19333701 2009
7
Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. 61 54
19218821 2009
8
Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique. 54 61
18528428 2008
9
Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma. 61 54
17870167 2008
10
LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. 54 61
18155167 2008
11
A new simple multi-well plate-based assay for monocyte differentiation using human monocytic leukemia THP-1 cells. 61 54
17920620 2007
12
MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells. 61 54
17694082 2007
13
LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). 54 61
17532767 2007
14
Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity. 54 61
17409565 2007
15
Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy. 61 54
17239427 2007
16
Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity. 61 54
17139107 2006
17
Rolling and adhesion of apoptotic monocytes is impaired by loss of functional cell surface-expressed P-selectin glycoprotein ligand-1. 61 54
16839361 2006
18
ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells. 61 54
16426569 2006
19
[Expression of SDF-1alpha and its receptor CXCR4 in acute leukemias and their relationship with extramedullary infiltration]. 61 54
16584580 2006
20
Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells. 61 54
16497166 2006
21
[In vitro stimulation of specific antileukemia T-cell response by dendritic cells derived from CD14+ acute monocytic leukemia cells]. 61 54
16552959 2005
22
MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. 54 61
16111539 2005
23
Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. 54 61
16164450 2005
24
Effect of montelukast on nuclear factor kappaB activation and proinflammatory molecules. 54 61
15984600 2005
25
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. 54 61
15767555 2005
26
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. 61 54
15680279 2005
27
Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. 54 61
15313893 2004
28
Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation. 54 61
15016631 2004
29
Proteasome inhibitors modulate chemokine production in lung epithelial and monocytic cells. 54 61
15293603 2004
30
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. 54 61
12738674 2003
31
Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1. 54 61
12819195 2003
32
A synergistic increase of apoptosis utilizing Fas antigen expression induced by low doses of anticancer drug. 61 54
13677932 2003
33
The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins. 61 54
12761814 2003
34
Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937. 61 54
12553012 2002
35
Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors. 61 54
12003967 2002
36
MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. 61 54
11965546 2002
37
PPARgamma ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells. 54 61
11861425 2002
38
WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. 54 61
11861382 2002
39
Regulation of gelatinase B in human monocytic and endothelial cells by PECAM-1 ligation and its modulation by interferon-beta. 54 61
11781384 2002
40
Augmented expression of P-gp/multi-drug resistance gene by all-trans retinoic acid in monocytic leukemic cells. 61 54
11734301 2002
41
Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma. 54 61
11739196 2001
42
Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. 54 61
11728449 2001
43
Effect of trapidil on effector functions of monocytes related to atherosclerotic plaque. 61 54
11689197 2001
44
Apoptosis induction by epigallocatechin gallate involves its binding to Fas. 54 61
11478767 2001
45
Effect of unique Mycobacterium leprae phenolic glycolipid-I (PGL-I) on tumour necrosis factor production by human mononuclear cells. 61 54
11355520 2001
46
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. 61 54
11243405 2001
47
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). 61 54
10824998 2000
48
Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells. 54 61
10848832 2000
49
Priming effects of macrophage colony-stimulating factor on monocytic leukemia cells in combination with chemotherapy: induction of programmed cell death in vivo. 61 54
10784404 2000
50
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway. 61 54
10639586 2000

Variations for Monocytic Leukemia

Expression for Monocytic Leukemia

Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for Monocytic Leukemia

Pathways related to Monocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 TNFRSF1A TNF JUN ITGAM IL6 IL1B
2
Show member pathways
13.96 TNFRSF1A TNF JUN ITGAM IL6 IL1B
3
Show member pathways
13.81 TNFRSF1A TNF JUN IL6 IL1B IFNG
4
Show member pathways
13.63 TNFRSF1A TNF JUN ITGAM IL6 IL1B
5
Show member pathways
13.56 TNFRSF1A TNF PPARG IL6 IL1B FAS
6
Show member pathways
13.55 TNFRSF1A TNF ITGAM IL6 IL1B FAS
7
Show member pathways
13.53 TNFRSF1A TNF PPARG JUN IL6 IL1B
8
Show member pathways
13.5 TNFRSF1A TNF ITGAM IL6 IL1B IFNG
9
Show member pathways
13.44 TNFRSF1A TNF JUN IL6 IL1B FAS
10
Show member pathways
13.32 TNFRSF1A TNF PPARG JUN IL6 IL1B
11
Show member pathways
13.1 TNFRSF1A TNF JUN IL6 IL1B FAS
12
Show member pathways
13.09 TNFRSF1A TNF IL6 FAS CSF1 CASP3
13
Show member pathways
13.01 TNF IL6 IL1B IFNG FAS CXCL8
14 13 PPARG JUN IL6 IFNG FAS CXCL8
15
Show member pathways
12.99 PPARG JUN ITGAM CSF2 CD14 CASP3
16 12.96 TNFRSF1A TNF IL6 IL1B IFNG FAS
17
Show member pathways
12.95 TNFRSF1A TNF JUN IL6 IL1B IFNG
18 12.93 TNFRSF1A TNF JUN IL1B FAS CSF1
19
Show member pathways
12.88 TNFRSF1A TNF JUN IL6 IL1B FAS
20
Show member pathways
12.87 TNF JUN IL6 IL1B CXCL8 CD14
21
Show member pathways
12.83 TNFRSF1A TNF JUN IL1B IFNG FAS
22
Show member pathways
12.82 TNFRSF1A TNF JUN ITGAM FAS CASP3
23
Show member pathways
12.8 TNFRSF1A TNF JUN FAS CASP3
24
Show member pathways
12.77 TNF JUN IL6 IL1B IFNG FAS
25
Show member pathways
12.74 TNFRSF1A TNF JUN IL1B FAS CASP3
26
Show member pathways
12.71 TNF JUN IL6 IL1B IFNG
27
Show member pathways
12.7 TNF IL6 IL1B IFNG CD14
28 12.68 TNFRSF1A TNF IL1B IFNG FAS
29
Show member pathways
12.68 TNF JUN IFNG FAS CSF2 CASP3
30 12.59 TNFRSF1A TNF JUN IL1B CXCL8 CSF2
31
Show member pathways
12.5 TNF JUN IL6 IL1B IFNG CXCL8
32 12.49 TNFRSF1A TNF JUN IL6 CSF2
33
Show member pathways
12.49 TNFRSF1A TNF IL6 CXCL8 CSF1
34
Show member pathways
12.48 TNF IL6 IL1B IFNG CSF1
35
Show member pathways
12.48 TNF JUN IL6 IL1B IFNG CXCL8
37 12.44 PPARG KMT2A ITGAM IL6 CXCL8 CSF2
38
Show member pathways
12.42 TNF JUN IL6 CXCL8 CD14
39
Show member pathways
12.42 TNFRSF1A TNF JUN ITGAM IL1B IFNG
40 12.4 TNF JUN IL6 IL1B CXCL8
41
Show member pathways
12.38 TNF IL6 IL1B IFNG CXCL8
42
Show member pathways
12.38 TNFRSF1A TNF JUN FAS CASP3
43
Show member pathways
12.37 TNFRSF1A TNF IL1B IFNG FAS
44 12.37 TNFRSF1A TNF ITGAM IL6 IL1B IFNG
45 12.36 TNF JUN IL6 IL1B CXCL8 CASP3
46 12.35 TNFRSF1A TNF FAS CASP3
47 12.35 TNFRSF1A TNF IL6 IFNG CASP3
48
Show member pathways
12.32 TNF JUN IL6 IL1B
49
Show member pathways
12.31 TNF JUN IL6 IL1B IFNG FAS
50 12.3 TNFRSF1A TNF IL1B FAS CASP3

GO Terms for Monocytic Leukemia

Cellular components related to Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 TNFRSF1A TNF KIAA0100 IL6 IL1B IFNG
2 extracellular space GO:0005615 9.65 TNFRSF1A TNF ITGAM IL6 IL1B IFNG
3 MOZ/MORF histone acetyltransferase complex GO:0070776 9.32 KAT6B KAT6A
4 death-inducing signaling complex GO:0031264 9.26 FAS CASP3
5 membrane raft GO:0045121 9.1 TNFRSF1A TNF ITGAM FAS CD14 CASP3

Biological processes related to Monocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNFRSF1A TNF PPARG KMT2A KAT6B KAT6A
2 positive regulation of cell proliferation GO:0008284 10.14 JUN IL6 IL1B IFNG CSF2 CSF1
3 apoptotic process GO:0006915 10.14 TNFRSF1A KMT2A IL1B IFNG FAS CD14
4 negative regulation of transcription, DNA-templated GO:0045892 10.08 TNF PPARG KAT6B KAT6A JUN IFNG
5 positive regulation of gene expression GO:0010628 10.04 TNF IL6 IL1B IFNG CXCL8 CSF2
6 positive regulation of apoptotic process GO:0043065 10.03 TNF PPARG JUN IL6 FAS CASP3
7 positive regulation of transcription, DNA-templated GO:0045893 10.03 TNF PPARG KMT2A KAT6B KAT6A JUN
8 positive regulation of protein phosphorylation GO:0001934 10.01 TNF IL1B IFNG FAS
9 immune response GO:0006955 10 TNF IL6 IL1B IFNG FAS CXCL8
10 response to lipopolysaccharide GO:0032496 9.99 JUN IL1B CD14 CASP3
11 defense response GO:0006952 9.98 TNFRSF1A TNF CYSLTR1 CXCL8
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.95 TNF PPARG IL6 IL1B
13 positive regulation of inflammatory response GO:0050729 9.92 TNFRSF1A TNF IL1B IFNG
14 positive regulation of interleukin-6 production GO:0032755 9.91 TNF IL6 IL1B IFNG
15 inflammatory response GO:0006954 9.91 TNFRSF1A TNF IL6 IL1B CXCL8 CSF1
16 cellular response to mechanical stimulus GO:0071260 9.9 TNFRSF1A IL1B FAS
17 cellular response to organic cyclic compound GO:0071407 9.9 TNF IL1B CASP3
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF IL1B CD14
19 response to glucocorticoid GO:0051384 9.9 TNF IL6 CASP3
20 response to organic substance GO:0010033 9.9 TNF PPARG JUN CASP3
21 positive regulation of interferon-gamma production GO:0032729 9.89 TNF IL1B CD14
22 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.89 TNFRSF1A TNF CD14
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 TNF JUN IL6
24 humoral immune response GO:0006959 9.88 TNF IL6 IFNG
25 positive regulation of interleukin-1 beta production GO:0032731 9.88 TNF IL6 IFNG
26 positive regulation of neuron apoptotic process GO:0043525 9.87 TNF JUN CASP3
27 positive regulation of cytokine production GO:0001819 9.87 TNF IFNG CD14
28 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IL1B IFNG
29 positive regulation of phagocytosis GO:0050766 9.86 TNF IL1B IFNG
30 extrinsic apoptotic signaling pathway GO:0097191 9.85 TNF IFNG FAS
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF IL1B IFNG
32 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.85 TNF PPARG JUN
33 positive regulation of chemokine production GO:0032722 9.84 TNF IL6 IFNG
34 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 TNF IL1B CSF2
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF IL1B CD14
36 microglial cell activation GO:0001774 9.83 TNF ITGAM IFNG
37 positive regulation of interleukin-8 production GO:0032757 9.83 TNF IL6 IL1B CD14
38 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
39 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL6 IL1B CXCL8 CSF2 CD14
40 positive regulation of osteoclast differentiation GO:0045672 9.79 TNF IFNG CSF1
41 macrophage differentiation GO:0030225 9.79 IFNG CSF2 CSF1
42 positive regulation of amyloid-beta formation GO:1902004 9.76 TNF IFNG CASP3
43 positive regulation of glial cell proliferation GO:0060252 9.75 TNF IL6 IL1B
44 negative regulation of amyloid-beta clearance GO:1900222 9.73 TNF IFNG
45 positive regulation of podosome assembly GO:0071803 9.73 TNF CSF2
46 positive regulation of monocyte differentiation GO:0045657 9.73 JUN CSF1
47 response to molecule of bacterial origin GO:0002237 9.73 CXCL8 CD14
48 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
49 necroptotic signaling pathway GO:0097527 9.72 TNF FAS
50 death-inducing signaling complex assembly GO:0071550 9.72 TNFRSF1A TNF

Molecular functions related to Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TNFRSF1A TNF PPARG KMT2A KIAA0100 KAT6B
2 cytokine activity GO:0005125 9.17 TNF IL6 IL1B IFNG CXCL8 CSF2
3 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF1A FAS

Sources for Monocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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