MCID: MNN002
MIFTS: 38

Mononeuritis Multiplex

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Mononeuritis Multiplex

MalaCards integrated aliases for Mononeuritis Multiplex:

Name: Mononeuritis Multiplex 11 19 75 53 14 71 75 31 33

Classifications:



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Disease Ontology 11 DOID:1835
ICD9CM 34 354.5
MeSH 43 D020422
NCIt 49 C70938
SNOMED-CT 68 30292005
ICD10 31 G58.7
ICD11 33 1838368265
UMLS 71 C0151295

Summaries for Mononeuritis Multiplex

GARD: 19 A painful asymmetric asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas; associated with (but not limited to) systemic disorders such as diabetes, vasculitis, amyloidosis, direct tumor involvement, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus, and paraneoplastic syndromes. It also may be associated with Lyme disease, Wegener's granulomatosis, Sjogren syndrome, cryoglobulinemia, hypereosinophilia, temporal arteritis, scleroderma, sarcoidosis, leprosy, acute viral hepatitis A, and acquired immunodeficiency syndrome.

MalaCards based summary: Mononeuritis Multiplex is related to livedoid vasculitis and churg-strauss syndrome. An important gene associated with Mononeuritis Multiplex is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include spinal cord, brain and small intestine, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia: 75 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Mononeuritis Multiplex

Diseases related to Mononeuritis Multiplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 692)
# Related Disease Score Top Affiliating Genes
1 livedoid vasculitis 30.6 PRTN3 APOH ADA2
2 churg-strauss syndrome 30.5 TNF PRTN3 MPO IL5 HLA-DRB1
3 hypereosinophilic syndrome 30.4 MPO IL5 FIP1L1
4 neuritis 30.4 TNF MAG DPYSL5
5 lyme disease 30.4 TNF HLA-DRB1 CRP
6 purpura 30.3 TNF HLA-DRB1 CRP APOH
7 vasculitis 30.3 TNF PRTN3 MPO HLA-DRB1 CRP APOH
8 glomerulonephritis 30.2 TNF PRTN3 MPO CRP
9 cauda equina syndrome 30.2 TNF CRP
10 coronary aneurysm 30.2 TNF CRP
11 acalculous cholecystitis 30.2 CRP CD4
12 hypereosinophilic syndrome, idiopathic 30.1 IL5 FIP1L1
13 microscopic polyangiitis 30.1 PRTN3 MPO HLA-DRB1 ADA2
14 typhoid fever 30.1 TNF HLA-DRB1 CRP
15 myositis 30.1 TRIM21 TNF HLA-DRB1
16 polyarteritis nodosa 30.1 TNF PRTN3 MPO HLA-DRB1 CRP APOH
17 spondylitis 30.0 TNF HLA-DRB1 CRP
18 conjunctivitis 30.0 TNF MPO IL5
19 peritonitis 30.0 TNF PRTN3 MPO CRP
20 bell's palsy 30.0 TNF CRP CD4
21 antiphospholipid syndrome 30.0 TNF CRP APOH
22 central retinal artery occlusion 30.0 PRTN3 MPO CRP ADA2
23 acute myocarditis 29.9 TNF CRP CD4
24 aseptic meningitis 29.9 TNF CRP CD4
25 mixed connective tissue disease 29.9 TNF HLA-DRB1 APOH
26 leprosy 3 29.9 TNF IL5 HLA-DRB1 CD4
27 optic neuritis 29.9 TNF MAG HLA-DRB1 DPYSL5
28 sarcoidosis 1 29.9 TNF PRTN3 HLA-DRB1 CRP CD4
29 autoimmune peripheral neuropathy 29.9 MAG CD4
30 myelitis 29.8 TNF DPYSL5 APOH
31 sjogren syndrome 29.8 TRIM21 SSB PRTN3 APOH
32 hepatitis a 29.8 TNF HLA-DRB1 CD4
33 granulomatous angiitis 29.8 PRTN3 CRP CD4
34 vascular disease 29.8 TNF MPO CRP APOH
35 polyradiculopathy 29.8 MAG DPYSL5 CD4
36 meningitis 29.8 TNF MPO IL5 CRP
37 otitis media 29.8 TNF MPO IL5 CRP
38 severe covid-19 29.7 TNF CRP CD4
39 demyelinating polyneuropathy 29.7 TNF MAG CRP CD4
40 choroiditis 29.7 TNF CRP CD4
41 meningoencephalitis 29.7 TNF CRP CD4
42 peripheral nervous system disease 29.6 TNF PRTN3 MPO MAG DPYSL5 CRP
43 hypersensitivity vasculitis 29.6 TNF PRTN3 MPO CRP CD4
44 henoch-schoenlein purpura 29.6 TNF PRTN3 MPO CRP CD4
45 exanthem 29.6 TRIM21 TNF PRTN3 MPO CRP CD4
46 acquired immunodeficiency syndrome 29.6 TNF CRP CD4
47 tenosynovitis 29.6 TNF PRTN3 CRP CD4
48 facial paralysis 29.6 TNF PRTN3 CRP CD4
49 spondyloarthropathy 1 29.6 TNF PRTN3 CRP CD4
50 posterior uveitis 29.5 TNF IL5 CD4

Comorbidity relations with Mononeuritis Multiplex via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Hypertension, Essential

Graphical network of the top 20 diseases related to Mononeuritis Multiplex:



Diseases related to Mononeuritis Multiplex

Symptoms & Phenotypes for Mononeuritis Multiplex

GenomeRNAi Phenotypes related to Mononeuritis Multiplex according to GeneCards Suite gene sharing:

25 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.66 ADA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 ADA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.66 ADA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.66 HLA-DRB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.66 SSB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.66 ADA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.66 HLA-DRB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.66 HLA-DRB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.66 SSB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 HLA-DRB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 HLA-DRB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.66 SSB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.66 ADA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.66 HLA-DRB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.66 ADA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.66 HLA-DRB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-27 9.66 SSB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.66 ADA2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.66 SSB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.66 ADA2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-86 9.66 HLA-DRB1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.66 ADA2

Drugs & Therapeutics for Mononeuritis Multiplex

Search Clinical Trials, NIH Clinical Center for Mononeuritis Multiplex

Genetic Tests for Mononeuritis Multiplex

Anatomical Context for Mononeuritis Multiplex

Organs/tissues related to Mononeuritis Multiplex:

MalaCards : Spinal Cord, Brain, Small Intestine, Neutrophil, Skin, Skeletal Muscle, Lung

Publications for Mononeuritis Multiplex

Articles related to Mononeuritis Multiplex:

(show top 50) (show all 665)
# Title Authors PMID Year
1
Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis. 53 62
19733002 2009
2
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis. 53 62
14514783 2003
3
[A reversible posterior leukoencephalopathy syndrome in a patient with classical polyarteritis nodosa]. 53 62
9146079 1997
4
Long-term Safety and Efficacy of Benralizumab for Eosinophilic Granulomatosis with Polyangiitis Complicated with Severe Neuropathy. 62
36171130 2022
5
Hypoglossal Nerve Palsy Following COVID-19 Vaccination in a Young Adult Complicated by Various Medicines. 62
36259036 2022
6
Acute exacerbation of idiopathic hypereosinophilic syndrome following asymptomatic coronavirus disease 2019: a case report. 62
36042524 2022
7
New-onset diabetic ketoacidosis with purpura fulminans in a child with COVID-19-related multisystem inflammatory syndrome. 62
35300573 2022
8
Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report. 62
36160656 2022
9
Clinical characteristics of patients with polyarteritis nodosa based on a nationwide database in Japan. 62
34894268 2022
10
ANCA-Associated Vasculitic Neuropathies: A Review. 62
35044596 2022
11
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis. 62
35110334 2022
12
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis. 62
35106968 2022
13
Mononeuritis multiplex as a rare and severe neurological complication of immune checkpoint inhibitors: a case report. 62
35197122 2022
14
Nephritis-associated plasmin receptor (NAPlr)-positive glomerulonephritis in a case of ANCA-negative small vessel vasculitis. 62
34389964 2022
15
Peripheral nervous system involvement in Q fever. 62
34487342 2022
16
Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections. 62
35812094 2022
17
Rituximab and mepolizumab combination therapy for glucocorticoid-resistant myocarditis related to eosinophilic granulomatosis with polyangiitis. 62
34473835 2022
18
A Case of Eosinophilic Granulomatosis with Polyangiitis Presenting with Mononeuritis Multiplex. 62
35352664 2022
19
Ultrasonic evidence of mononeuritis multiplex caused by Lyme neuroborreliosis. 62
34644405 2022
20
Primary peripheral T-cell lymphoma of the cervix with mononeuritis multiplex: an unusual case presentation. 62
35252047 2022
21
The Diagnostic Challenge of Eosinophilic Granulomatosis With Polyangiitis Presenting as Acute Eosinophilic Myocarditis: Case Report and Literature Review. 62
35872900 2022
22
Unveiling Uncommon Manifestations in a Pediatric Patient With Systemic Lupus Erythematosus: A Case Report. 62
35047258 2021
23
Lupus Vasculitis: An Overview. 62
34829857 2021
24
From Head to Toe: Granulomatosis with Polyangiitis. 62
34652975 2021
25
Cryoglobulinemic Vasculitic Mononeuritis Multiplex in a Teenager. 62
34416514 2021
26
Pediatric onset lupus nephritis in western India-is it different from the rest of the country? 62
34558344 2021
27
Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis. 62
34544704 2021
28
Multiple mononeuritis with peripheral blood eosinophilia in a patient with Q fever: An unusual presentation: Case report and review of the literature. 62
33902992 2021
29
Vasculitic peripheral neuropathy in deficiency of adenosine deaminase 2. 62
34210540 2021
30
Mononeuritis multiplex: an unexpectedly frequent feature of severe COVID-19. 62
33244712 2021
31
Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseases. 62
34056884 2021
32
Leprous Neuropathy: Observational Study Highlighting the Role of Electrophysiology in Early Diagnosis. 62
34295108 2021
33
Pembrolizumab-Associated CD8+ Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma. 62
33824184 2021
34
Idiopathic hypereosinophilic syndrome presenting as mononeuritis multiplex. Lessons learned after 18-months of follow-up. 62
34714239 2021
35
Neurological manifestations of polyarteritis nodosa: a tour of the neuroaxis by case series. 62
34020612 2021
36
Hypocomplementemic urticarial vasculitis syndrome presenting with bilateral scleritis. 62
33972296 2021
37
Early add-on administration of mepolizumab and intravenous immunoglobulin effective in treating eosinophilic granulomatosis with polyangiitis. 62
33305381 2021
38
Prevalence of Eosinophilic Granulomatosis With Polyangiitis and Associated Health Care Utilization Among Patients With Concomitant Asthma in US Commercial Claims Database. 62
31693654 2021
39
ANCA-Negative Churg-Strauss Syndrome Presenting as Bilateral Central Retinal Artery Occlusion: A Case Report 62
33951903 2021
40
[Clinical analysis of 46 rheumatoid arthritis patients with peripheral neuropathy]. 62
33663170 2021
41
Clinical features and outcomes from the Singapore Sjögren's syndrome study. 62
33259751 2021
42
"Person-in-the-Barrel" Syndrome: A Case Report of Bilateral Arm Paresis Due to Vasculitis With a Review of Pathological Mechanisms. 62
33816006 2021
43
Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. 62
33526532 2021
44
36-month follow-up of a pure sensory mononeuritis multiplex and IgG1 deficiency improved after treatment with sitagliptin and Vitamin D3. 62
33660837 2021
45
Leukocytoclastic vasculitis associated with multifocal sensory neuropathy responsive to intravenous immunoglobulins: a case report. 62
34744418 2021
46
Sensory-Motor Polyneuropathy and Digital Ischemia: A Rare Presentation of Granulomatosis with Polyangiitis. 62
34751236 2021
47
Immune Axonal Neuropathies Associated With Systemic Autoimmune Rheumatic Diseases. 62
33935704 2021
48
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult. 62
33181855 2020
49
Mononeuritis multiplex secondary to Lyme neuroborreliosis. 62
32993951 2020
50
[MICROSCOPIC POLYANGIITIS WITH VARIABLE PRESENTATION]. 62
33210846 2020

Variations for Mononeuritis Multiplex

Expression for Mononeuritis Multiplex

Search GEO for disease gene expression data for Mononeuritis Multiplex.

Pathways for Mononeuritis Multiplex

GO Terms for Mononeuritis Multiplex

Biological processes related to Mononeuritis Multiplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.76 TRIM21 TNF HLA-DRB1 CD4
2 positive regulation of monocyte differentiation GO:0045657 9.62 HLA-DRB1 CD4
3 negative regulation of lipid storage GO:0010888 9.56 TNF CRP
4 response to gold nanoparticle GO:1990268 9.26 TNF MPO
5 positive regulation of viral entry into host cell GO:0046598 9.1 TRIM21 HLA-DRB1 CD4

Sources for Mononeuritis Multiplex

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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