MCID: MNN002
MIFTS: 38

Mononeuritis Multiplex

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Mononeuritis Multiplex

MalaCards integrated aliases for Mononeuritis Multiplex:

Name: Mononeuritis Multiplex 12 73 20 54 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1835
ICD9CM 34 354.5
MeSH 44 D020422
NCIt 50 C70938
SNOMED-CT 67 30292005
ICD10 32 G58.7
UMLS 70 C0151295

Summaries for Mononeuritis Multiplex

MalaCards based summary : Mononeuritis Multiplex is related to anca-associated vasculitis and vasculitis. An important gene associated with Mononeuritis Multiplex is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Hematopoietic cell lineage and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include spinal cord, skin and neutrophil, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Mononeuritis Multiplex

Diseases related to Mononeuritis Multiplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 598)
# Related Disease Score Top Affiliating Genes
1 anca-associated vasculitis 30.8 PRTN3 MPO
2 vasculitis 30.7 TNF PRTN3 MPO CRP ADA2
3 polyarteritis nodosa 30.6 PRTN3 MPO CRP ADA2
4 hypereosinophilic syndrome 30.4 MPO IL5 CCL26
5 branch retinal artery occlusion 30.4 PRTN3 CRP
6 leprosy 3 30.4 TNF IL5 CD4
7 purpura 30.3 TNF CRP ACE
8 central retinal artery occlusion 30.3 PRTN3 CRP
9 coronary aneurysm 30.3 TNF CRP
10 churg-strauss syndrome 30.3 TNF PRTN3 MPO IL5 CCL26
11 polyneuropathy 30.2 TNF MAG CRP ACE
12 spondyloarthropathy 1 30.1 TNF PRTN3 CRP
13 meningoencephalitis 30.0 TNF CRP CD4
14 epidemic typhus 30.0 TNF CRP CD4
15 lymphadenitis 30.0 TNF CRP CD4
16 meningitis 30.0 TNF IL5 CRP
17 monoclonal gammopathy of uncertain significance 30.0 TNF MYOM2 MAG
18 conjunctivitis 30.0 TNF MPO IL5
19 peritonitis 30.0 TNF PRTN3 MPO CRP
20 sarcoidosis 1 29.9 TNF CRP CD4 ACE
21 acquired immunodeficiency syndrome 29.9 TNF CRP CD4
22 allergic disease 29.9 TNF MPO IL5
23 tenosynovitis 29.8 TNF PRTN3 CRP CD4
24 otitis media 29.8 TNF MPO IL5 CRP
25 esophagitis 29.7 TNF IL5 CCL26
26 pericarditis 29.7 TNF CRP ACE
27 severe acute respiratory syndrome 29.7 TNF CRP ACE
28 henoch-schoenlein purpura 29.6 PRTN3 MPO CRP ACE
29 acute myocarditis 29.6 TNF CRP CD4 ACE
30 peripheral nervous system disease 29.6 TNF MYOM2 MAG CRP CD4 ACE
31 mononeuropathy 29.5 TRIM21 TNF SSB PRTN3 MPO MAG
32 mononeuritis of upper limb and mononeuritis multiplex 29.5 TRIM21 TNF SSB PRTN3 MYOM2 MPO
33 hypersensitivity vasculitis 29.5 TNF PRTN3 MPO CRP ACE
34 cranial nerve palsy 29.5 PRTN3 CRP CD4 ACE
35 granulomatous angiitis 29.4 PRTN3 IL5 CRP ACE
36 neurosarcoidosis 29.4 TNF CRP CD4 ACE
37 pancytopenia 29.4 CRP CD4 ACE
38 autoimmune disease 29.3 TRIM21 TNF PRTN3 MPO IL5 CRP
39 exanthem 29.3 TRIM21 TNF PRTN3 CRP CD4 ACE
40 chronic kidney disease 29.2 TNF MPO CRP ACE
41 facial paralysis 29.2 TNF PRTN3 CRP CD4 ACE
42 connective tissue disease 29.1 TNF SSB CRP CD4 ACE
43 granulomatosis with polyangiitis 28.9 TNF PRTN3 MPO IL5 CRP CD4
44 systemic lupus erythematosus 28.4 TRIM21 TNF SSB PRTN3 MPO IL5
45 amyotrophy, hereditary neuralgic 11.2
46 neuropathy 10.5
47 allergic angiitis 10.5
48 frontal sinusitis 10.4 PRTN3 CRP
49 orbital plasma cell granuloma 10.4 PRTN3 CRP
50 bicipital tenosynovitis 10.4 PRTN3 CRP

Comorbidity relations with Mononeuritis Multiplex via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Hypertension, Essential

Graphical network of the top 20 diseases related to Mononeuritis Multiplex:



Diseases related to Mononeuritis Multiplex

Symptoms & Phenotypes for Mononeuritis Multiplex

MGI Mouse Phenotypes related to Mononeuritis Multiplex:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 ACE CD4 IL5 MAG MPO PRTN3
2 immune system MP:0005387 9.32 ACE CD4 CRP IL5 MAG MPO

Drugs & Therapeutics for Mononeuritis Multiplex

Search Clinical Trials , NIH Clinical Center for Mononeuritis Multiplex

Genetic Tests for Mononeuritis Multiplex

Anatomical Context for Mononeuritis Multiplex

MalaCards organs/tissues related to Mononeuritis Multiplex:

40
Spinal Cord, Skin, Neutrophil, Small Intestine, Liver, Heart, Skeletal Muscle

Publications for Mononeuritis Multiplex

Articles related to Mononeuritis Multiplex:

(show top 50) (show all 628)
# Title Authors PMID Year
1
Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis. 54 61
19733002 2009
2
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis. 61 54
14514783 2003
3
[A reversible posterior leukoencephalopathy syndrome in a patient with classical polyarteritis nodosa]. 61 54
9146079 1997
4
Prevalence of Eosinophilic Granulomatosis With Polyangiitis and Associated Health Care Utilization Among Patients With Concomitant Asthma in US Commercial Claims Database. 61
31693654 2021
5
Early add-on administration of mepolizumab and intravenous immunoglobulin effective in treating eosinophilic granulomatosis with polyangiitis. 61
33305381 2021
6
[Clinical analysis of 46 rheumatoid arthritis patients with peripheral neuropathy]. 61
33663170 2021
7
Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. 61
33526532 2021
8
Clinical features and outcomes from the Singapore Sjögren's syndrome study. 61
33259751 2021
9
36-month follow-up of a pure sensory mononeuritis multiplex and IgG1 deficiency improved after treatment with sitagliptin and Vitamin D3. 61
33660837 2021
10
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult. 61
33181855 2020
11
Mononeuritis multiplex secondary to Lyme neuroborreliosis. 61
32993951 2020
12
Mononeuritis multiplex: an unexpectedly frequent feature of severe COVID-19. 61
33244712 2020
13
[MICROSCOPIC POLYANGIITIS WITH VARIABLE PRESENTATION]. 61
33210846 2020
14
Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system: Description of a cohort. 61
33019390 2020
15
Spectrum and Prognosis of Antineutrophil Cytoplasmic Antibody-associated Vasculitis-related Bronchiectasis: Data from 61 Patients. 61
31787599 2020
16
Vasculitic mononeuritis multiplex associated with livedoid vasculopathy. 61
31771777 2020
17
Case report: Mononeuritis multiplex in the course of dengue fever. 61
32962669 2020
18
Improvement of pure sensory mononeuritis multiplex and IgG1 deficiency with sitagliptin plus Vitamin D3. 61
32767343 2020
19
Microscopic polyangiitis: Clinical characteristics and long-term outcomes of 378 patients from the French Vasculitis Study Group Registry. 61
32340774 2020
20
Primary livedoid vasculopathy associated with mononeuritis multiplex. 61
32898400 2020
21
Mononeuritis Multiplex as Initial Manifestation of Pure Neuritic Leprosy-A Forgotten Cause: Clinical, Electrodiagnostic and Pathologic Correlations. 61
32859845 2020
22
Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for Mycobacterium leprae DNA by Polymerase Chain Reaction Method. 61
32285768 2020
23
Eosinophilic granulomatosis with polyangiitis presenting with myositis: case based review. 61
32270295 2020
24
Rheumatologic Disorders and the Nervous System. 61
32487898 2020
25
Eosinophilic granulomatosis with polyangiitis: understanding the disease and its management. 61
32348510 2020
26
Clinical associations of renal involvement in ANCA-associated vasculitis. 61
32068190 2020
27
Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes, and Adverse Events. 61
31203225 2020
28
Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis. 61
32209573 2020
29
Mononeuritis Multiplex Associated With Antiphospholipid Antibodies. 61
32637932 2020
30
Immunosuppressive treatment for peripheral neuropathies in Sjogren's syndrome - a systematic review. 61
31527298 2020
31
Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades. 61
31735796 2020
32
[Mononeuritis Multiplex: A Diagnostic Challenge]. 61
32456580 2020
33
Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China. 61
32714994 2020
34
Microscopic polyangiitis: an incidental finding in a patient with stroke. 61
32128059 2020
35
Phlebectasia in a finger in a case of microscopic polyangiitis with peripheral polyneuropathy. 61
28838824 2019
36
Multiple Neurologic Deficits and Cognitive Decline in a Young Woman. 61
31736585 2019
37
Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies. 61
31405908 2019
38
Myopericarditis as a presentation of eosinophilic granulomatosus with polyangiitis (EGPA). 61
31420437 2019
39
A challenging diagnosis of MPO-C-ANCA EGPA. 61
31296634 2019
40
The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients. 61
30541137 2019
41
Neurologic manifestations associated with cryoglobulinemia: A single center experience. 61
30708209 2019
42
Rare presentation of granulomatosis with polyangiitis. 61
30798274 2019
43
Vertigo and Severe Balance Instability as Symptoms of Lyme Disease-Literature Review and Case Report. 61
31798513 2019
44
Severe mononeuritis multiplex in a patient with eosinophilic granulomatosis with polyangiitis. 61
31844342 2019
45
Novel Neuropathic Pain Mechanisms Associated With Allergic Inflammation. 61
31920952 2019
46
Vasculitic neuropathy associated with Rheumatoid Arthritis, a case report. 61
31723390 2019
47
Clinical, electrophysiological and laboratory parameters, and outcome in patients with biopsy proven systemic and nonsystemic vasculitic neuropathy. 61
30688236 2019
48
[A Case of Sjögren's Syndrome with Multiple Stenoses of the Cerebral Arteries and Transient Neurological Symptoms and Signs]. 61
30523219 2018
49
Ruptured renal artery in microscopic polyangiitis: a case report and literature review. 61
29951966 2018
50
Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient. 61
30419847 2018

Variations for Mononeuritis Multiplex

Expression for Mononeuritis Multiplex

Search GEO for disease gene expression data for Mononeuritis Multiplex.

Pathways for Mononeuritis Multiplex

GO Terms for Mononeuritis Multiplex

Cellular components related to Mononeuritis Multiplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TNF PRTN3 MPO IL5 CRP CCL26
2 azurophil granule lumen GO:0035578 9.43 PRTN3 MPO ADA2
3 membrane raft GO:0045121 9.26 TNF PRTN3 MAG CD4
4 extracellular space GO:0005615 9.23 TNF PRTN3 MPO IL5 CRP CCL26

Biological processes related to Mononeuritis Multiplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 TNF IL5 CRP CCL26
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.5 TRIM21 TNF IL5
3 positive regulation of viral entry into host cell GO:0046598 9.26 TRIM21 CD4
4 cytokine-mediated signaling pathway GO:0019221 9.26 TNF PRTN3 IL5 CD4
5 positive regulation of podosome assembly GO:0071803 9.16 TNF IL5
6 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Sources for Mononeuritis Multiplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....