MCID: MNN015
MIFTS: 19

Mononeuritis of Lower Limb

Categories: Neuronal diseases

Aliases & Classifications for Mononeuritis of Lower Limb

MalaCards integrated aliases for Mononeuritis of Lower Limb:

Name: Mononeuritis of Lower Limb 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9473
ICD9CM 34 355.8
UMLS 71 C0154747

Summaries for Mononeuritis of Lower Limb

MalaCards based summary : Mononeuritis of Lower Limb is related to tibial nerve palsy and charcot-marie-tooth disease type x. An important gene associated with Mononeuritis of Lower Limb is RPL34 (Ribosomal Protein L34), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Mononeuritis of Lower Limb

Diseases related to Mononeuritis of Lower Limb via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 tibial nerve palsy 10.4 RPL34 PMP22
2 charcot-marie-tooth disease type x 10.2 SH3TC2 PMP22
3 charcot-marie-tooth disease, type 4b3 10.2 SH3TC2 PMP22
4 charcot-marie-tooth disease, x-linked dominant, 1 10.2 SH3TC2 PMP22
5 charcot-marie-tooth disease, demyelinating, type 1b 10.2 SH3TC2 PMP22
6 spondylolysis 10.2 RPL34 HECTD4
7 peroneal nerve paralysis 10.2 PMP22 HECTD4
8 charcot-marie-tooth disease, demyelinating, type 1c 10.2 SH3TC2 PMP22
9 lumbosacral lipoma 10.2 RPL34 HECTD4
10 spondylolisthesis 10.1 RPL34 HECTD4
11 spondylosis 10.1 RPL34 HECTD4
12 neurogenic arthropathy 10.1 NGF HECTD4
13 ocular dominance 10.1 NTF3 NGF
14 hypochondriasis 10.0 NTF4 NTF3
15 detrusor sphincter dyssynergia 10.0 TRPV1 NGF
16 radiculopathy 10.0 RPL34 PMP22 HECTD4
17 diabetic autonomic neuropathy 10.0 NTF3 NGF
18 plexopathy 10.0 RPL34 PMP22 HECTD4
19 cough variant asthma 10.0 TRPV1 NGF
20 cauda equina syndrome 10.0 RPL34 PMP22 HECTD4
21 chronic cystitis 10.0 TRPV1 NGF
22 decubitus ulcer 10.0 NGF HECTD4
23 neuropathy, hereditary, with liability to pressure palsies 10.0 SH3TC2 PMP22
24 trigeminal nerve disease 10.0 TRPV1 NGF
25 diabetic polyneuropathy 9.9 NTF3 NGF
26 chronic ulcer of skin 9.9 NGF HECTD4
27 polyneuropathy 9.9 SH3TC2 PMP22 NGF
28 bone structure disease 9.9 SH3TC2 RPL34 HECTD4
29 trigeminal neuralgia 9.9 TRPV1 NGF
30 myofascial pain syndrome 9.9 TRPV1 HECTD4
31 subungual glomus tumor 9.9 TRPV1 HECTD4
32 charcot-marie-tooth disease, demyelinating, type 1a 9.9 SH3TC2 PMP22 NTF3
33 burning mouth syndrome 9.9 TRPV1 NGF
34 neurogenic bladder 9.8 TRPV1 NGF
35 demyelinating disease 9.8 PMP22 NTF3 NGF
36 autonomic nervous system disease 9.8 TRPV1 NGF
37 cataract 38 9.8 NTF4 NTF3 NGF
38 paroxysmal extreme pain disorder 9.7 TRPV1 NGF
39 secondary progressive multiple sclerosis 9.7 NTF4 NTF3 NGF
40 demyelinating polyneuropathy 9.7 PMP22 NGF
41 neuropathy, congenital hypomyelinating, 1, autosomal recessive 9.7 SH3TC2 PMP22 NTF3
42 serous labyrinthitis 9.7 NTF4 NTF3 HECTD4
43 paine syndrome 9.6 TRPV1 NGF HECTD4
44 somatoform disorder 9.6 TRPV1 NGF HECTD4
45 interstitial cystitis 9.6 TRPV1 NTF3 NGF
46 cystitis 9.6 TRPV1 NTF3 NGF
47 charcot-marie-tooth disease, axonal, type 2e 9.6 SH3TC2 PMP22 NTF3 NGF
48 neuromuscular disease 9.5 SH3TC2 PMP22 HECTD4
49 pain agnosia 9.4 TRPV1 RPL34 NGF HECTD4
50 agnosia 9.4 TRPV1 RPL34 NGF HECTD4

Graphical network of the top 20 diseases related to Mononeuritis of Lower Limb:



Diseases related to Mononeuritis of Lower Limb

Symptoms & Phenotypes for Mononeuritis of Lower Limb

MGI Mouse Phenotypes related to Mononeuritis of Lower Limb:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.61 ANKRD1 CIB2 NGF NTF3 NTF4 PMP22
2 homeostasis/metabolism MP:0005376 9.28 ANKRD1 CIB2 NGF NTF3 NTF4 PMP22

Drugs & Therapeutics for Mononeuritis of Lower Limb

Search Clinical Trials , NIH Clinical Center for Mononeuritis of Lower Limb

Genetic Tests for Mononeuritis of Lower Limb

Anatomical Context for Mononeuritis of Lower Limb

Publications for Mononeuritis of Lower Limb

Variations for Mononeuritis of Lower Limb

Expression for Mononeuritis of Lower Limb

Search GEO for disease gene expression data for Mononeuritis of Lower Limb.

Pathways for Mononeuritis of Lower Limb

Pathways related to Mononeuritis of Lower Limb according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 NTF4 NTF3 NGF
2
Show member pathways
11.35 NTF4 NTF3 NGF
3 11.23 NTF4 NTF3 NGF
4
Show member pathways
10.95 NTF4 NTF3 NGF
5 10.87 TRPV1 NGF
6
Show member pathways
10.81 TRPV1 NTF3
7
Show member pathways
10.58 NTF4 NTF3 NGF

GO Terms for Mononeuritis of Lower Limb

Cellular components related to Mononeuritis of Lower Limb according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 TRPV1 NTF4 NTF3 NGF
2 synaptic vesicle GO:0008021 8.8 NTF4 NTF3 NGF

Biological processes related to Mononeuritis of Lower Limb according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.69 NTF4 NTF3 NGF
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.63 NTF4 NTF3 NGF
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 NTF4 NTF3 NGF
4 modulation of chemical synaptic transmission GO:0050804 9.58 NTF4 NTF3 NGF
5 memory GO:0007613 9.54 NTF4 NTF3 NGF
6 neuron projection morphogenesis GO:0048812 9.5 NTF4 NTF3 NGF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.49 NTF4 NGF
8 cellular response to ATP GO:0071318 9.48 TRPV1 CIB2
9 regulation of neuron differentiation GO:0045664 9.43 NTF4 NTF3 NGF
10 nerve development GO:0021675 9.33 NTF4 NTF3 NGF
11 nerve growth factor signaling pathway GO:0038180 9.13 NTF4 NTF3 NGF
12 peripheral nervous system development GO:0007422 8.92 PMP22 NTF4 NTF3 NGF

Molecular functions related to Mononeuritis of Lower Limb according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme inhibitor activity GO:0004857 9.16 SLN NGF
2 growth factor activity GO:0008083 9.13 NTF4 NTF3 NGF
3 nerve growth factor receptor binding GO:0005163 8.8 NTF4 NTF3 NGF

Sources for Mononeuritis of Lower Limb

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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