Aliases & Classifications for Mononeuropathy

MalaCards integrated aliases for Mononeuropathy:

Name: Mononeuropathy 12 15 17
Mononeuropathies 54 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1188
MeSH 43 D020422
ICD10 32 G58.8 G58.9 G59
UMLS 71 C0494491

Summaries for Mononeuropathy

Disease Ontology : 12 A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.

MalaCards based summary : Mononeuropathy, also known as mononeuropathies, is related to femoral neuropathy and cranial nerve disease, and has symptoms including neuralgia An important gene associated with Mononeuropathy is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2), and among its related pathways/superpathways is Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and b cells, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Mononeuropathy

Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 431)
# Related Disease Score Top Affiliating Genes
1 femoral neuropathy 33.2 RPL34 PES1
2 cranial nerve disease 32.3 PES1 CRP CD40LG
3 diabetic neuropathy 31.9 TRPV1 PMP22 NGF MPZ
4 peroneal nerve paralysis 31.5 PMP22 PES1 HECTD4
5 carpal tunnel syndrome 31.5 TAC1 SH3TC2 PMP22 MPZ
6 ulnar neuropathy 31.0 PMP22 ARHGEF10
7 tarsal tunnel syndrome 31.0 PES1 HECTD4
8 common peroneal nerve lesion 30.9 RPL34 HECTD4
9 radiculopathy 30.8 TAC1 RPL34 HECTD4
10 vasculitis 30.8 TNFRSF1B PRTN3 MPO CRP CD40LG
11 foot drop 30.8 PMP22 MPZ
12 churg-strauss syndrome 30.7 PRTN3 MPO CD40LG
13 polyarteritis nodosa 30.6 PRTN3 MPO CRP
14 plexopathy 30.5 RPL34 PMP22 HECTD4 CD40LG
15 anca-associated vasculitis 30.5 PRTN3 MPO
16 tolosa-hunt syndrome 30.5 PRTN3 CRP
17 tibial neuropathy 30.5 PES1 HECTD4
18 granulomatous angiitis 30.4 PRTN3 CRP
19 hereditary neuropathies 30.4 PMP22 MPZ MAG
20 neuritis 30.4 PMP22 MPZ MAG
21 facial paralysis 30.3 PRTN3 CRP CD40LG
22 neurosarcoidosis 30.2 TNFRSF1B CRP
23 chickenpox 30.2 TNFRSF1B CRP CD40LG
24 exostosis 30.1 RPL34 PES1 HECTD4
25 brachial plexus neuropathy 30.1 PMP22 MPZ CD40LG
26 arachnoiditis 30.1 TAC1 RPL34 CRP
27 subacute bacterial endocarditis 30.1 PRTN3 MPO CRP CD40LG
28 hypersensitivity vasculitis 30.1 PRTN3 MPO CRP CD40LG
29 herpes zoster 30.0 TRPV1 TNFRSF1B CRP CD40LG
30 xerophthalmia 30.0 TRIM21 CRP CD40LG
31 collagen disease 29.9 TRIM21 CRP CD40LG
32 lesion of sciatic nerve 29.9 SH3TC2 RPL34 PMP22 PES1 NGF
33 guillain-barre syndrome 29.8 TNFRSF1B PMP22 MPZ CD40LG
34 demyelinating polyneuropathy 29.8 PMP22 NGF MAG
35 granulomatosis with polyangiitis 29.8 TNFRSF1B PRTN3 MPO CRP CD40LG
36 exanthem 29.7 TRIM21 TNFRSF1B PRTN3 CRP CD40LG
37 keratoconjunctivitis sicca 29.7 TRIM21 NGF CD40LG
38 polyneuropathy 29.6 SH3TC2 PMP22 NGF MPZ MAG CRP
39 neuropathy, hereditary, with liability to pressure palsies 29.5 SH3TC2 PMP22 PES1 MPZ MAG ARHGEF10
40 autoimmune disease 29.5 TRIM21 TNFRSF1B PRTN3 CRP CD40LG
41 anxiety 29.4 TAC1 NGF GAL CRP
42 polyradiculoneuropathy 29.3 RPL34 PMP22 MPZ MAG CD40LG
43 aspiration pneumonia 29.3 TRPV1 TAC1 HECTD4 CRP CD40LG
44 pain agnosia 29.2 TRPV1 TAC1 RPL34 NGF HECTD4
45 demyelinating disease 29.1 PMP22 NGF MPZ MAG CD40LG
46 mononeuritis multiplex 28.9 TRIM21 TNFRSF1B PRTN3 PMP22 MYOM2 MPO
47 neuromuscular disease 28.7 SH3TC2 PMP22 PES1 MPZ MAG HECTD4
48 peripheral nervous system disease 26.5 TRPV1 TAC1 SH3TC2 RPL34 PMP22 PES1
49 mononeuropathy of the median nerve, mild 12.7
50 radial neuropathy 11.5

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to Mononeuropathy

Symptoms & Phenotypes for Mononeuropathy

UMLS symptoms related to Mononeuropathy:


neuralgia

MGI Mouse Phenotypes related to Mononeuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.47 ARHGEF10 CD40LG CRP GAL MAG MPO

Drugs & Therapeutics for Mononeuropathy

Drugs for Mononeuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 3 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
3 Anti-Anxiety Agents Phase 3
4 Analgesics Phase 3
5 Tranquilizing Agents Phase 3
6 Psychotropic Drugs Phase 3
7 Anticonvulsants Phase 3
8 Calcium, Dietary Phase 3
9 calcium channel blockers Phase 3
10 Hormones Phase 3
11 Immunologic Factors Phase 3
12 Rho(D) Immune Globulin Phase 3
13 Immunoglobulins Phase 3
14 Antibodies Phase 3
15 Immunoglobulins, Intravenous Phase 3
16 gamma-Globulins Phase 3
17 Central Nervous System Depressants Phase 2
18 Pharmaceutical Solutions Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Multi-center, Randomized, Double-blind, Parallel, Active-controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' and 'Pregabalin' in Peripheral Neuropathic Pain Completed NCT03221907 Phase 3 GLA5PR GLARS-NF1;GLA5PR GLARS-NF1 placebo;Pregabalin;Pregabalin placebo
2 Prospective, Randomised, Placebo-controlled Study of Polyvalent Intravenous Immunoglobulins for the Treatment of Primary Sjögren's Syndrome Associated Painful Sensory Neuropathies Recruiting NCT03700138 Phase 3 Privigen® 100mg/ml at the dose of 2g/kg of body weight;NaCl 0,9%
3 A Multicenter, Randomized, Double-Blind, Placebo and Active Controlled Study Comparing the Analgesic Efficacy and Safety of ABT-639 to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
4 A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Three Doses of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Completed NCT00229437 Phase 2 TAK-128;TAK-128;TAK-128;Placebo
5 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of RWJ 333369 for the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy. Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
6 An Open-Label, Multi-Center Study to Evaluate the Safety of Long-Term Administration of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Terminated NCT00756041 Phase 2 TAK-128
7 A Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Subjects With Postherpetic Neuralgia and Post-traumatic Neuralgia, Followed by a Double Blind Safety Extension and an Open-label Safety Extension Terminated NCT00964990 Phase 2 JNJ-42160443;Placebo
8 To Investigate the Therapeutic Effect of Aculife Magnetic Therapist on Carpal Tunnel Syndrome Unknown status NCT01277003
9 Predicting Outcome of Transcutaneous Electrical Nerve Stimulator (TENS) in Failed Back Surgery Syndrome Unknown status NCT01185665
10 Role of Sensory Potentials and High-resolution Ultrasonography in Confirmation of Common Peroneal Mononeuropathy at the Fibular Neck Completed NCT03753178
11 Conservative Treatment Versus Ultrasound Guided Injection in Management of Meralgia Paresthetica: A Randomized Controlled Trial Completed NCT04004052
12 Effects of Platelet-rich Plasma in the Surgery of Carpal Tunnel Syndrome: A Randomized Completed NCT03548259
13 Amniotic Membrane Transplantation for Carpal Tunnel Syndrome Treatment: One-year Follow-up Completed NCT04075357
14 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175
15 Innovative Ultrasound Technology in Neuromuscular Disease Recruiting NCT02104921
16 Neuropathic Pain in Jamaicans With Sickle Cell Disease Recruiting NCT04015401
17 Study of Superior Gluteal Mononeuropathy After Total Hip Arthroplasty Through Modified Direct Lateral Approach Not yet recruiting NCT03492684
18 Effect of Age on the Median Effective Concentration(EC50) for Motor Block With Spinal Plain Bupivacaine Withdrawn NCT02141841

Search NIH Clinical Center for Mononeuropathy

Cochrane evidence based reviews: mononeuropathies

Genetic Tests for Mononeuropathy

Anatomical Context for Mononeuropathy

MalaCards organs/tissues related to Mononeuropathy:

40
Spinal Cord, Brain, B Cells, Skin, Testes, Bone, Lung

Publications for Mononeuropathy

Articles related to Mononeuropathy:

(show top 50) (show all 1477)
# Title Authors PMID Year
1
Unusual presentation of hereditary neuropathy with liability to pressure palsies. 54 61
18218131 2008
2
Hereditary neuropathy with liability to pressure palsies in infancy. 54 61
12849887 2003
3
DNA rearrangements on both homologues of chromosome 17 in a mildly delayed individual with a family history of autosomal dominant carpal tunnel syndrome. 54 61
9973284 1999
4
Detection of hereditary neuropathy with liability to pressure palsies among patients with acute painless mononeuropathy or plexopathy. 54 61
9843070 1998
5
Neuromuscular Mimics of Entrapment Neuropathies of Upper Extremities. 61
32020820 2020
6
Postsurgical Neuropathy: A Descriptive Review. 61
32029088 2020
7
Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. 61
31390162 2020
8
Meralgia paresthetica: finding an effective cure. 61
31566048 2020
9
Pain and small-fiber affection in hereditary neuropathy with liability to pressure palsies (HNPP). 61
31536037 2019
10
Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses. 61
31659433 2019
11
Thrombotic microangiopathy involving kidney allograft and peripheral nerves. 61
31816173 2019
12
Neurosarcoidosis presenting with a partial Claude syndrome. 61
31748369 2019
13
Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitides: Insights from the DCVAS study. 61
31540965 2019
14
Can imaging be the new yardstick for diagnosing peripheral neuropathy?-a comparison between high resolution ultrasound and MR neurography with an approach to diagnosis. 61
31676930 2019
15
Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross-sectional study. 61
31762210 2019
16
Ultrasound in the diagnosis and management of fibular mononeuropathy. 61
31361339 2019
17
Prospective case series on the use of peripheral nerve stimulation for focal mononeuropathy treatment. 61
31686589 2019
18
Cholecalciferol (Vitamin D3) Reduces Rat Neuropathic Pain by Modulating Opioid Signaling. 61
31001801 2019
19
Ultrasound-Guided Incisionless Carpal Tunnel Release Using a Hook Knife: A Cadaveric Study. 61
30734506 2019
20
Neuromuscular Ultrasound for Peripheral Neuropathies. 61
31639837 2019
21
The usefulness of electrodiagnostic consultation in an outpatient clinic. 61
31227402 2019
22
[Multiple mononeuropathy associated with systemic sclerosis with vasculitis confirmed by nerve biopsy: a case report]. 61
31474645 2019
23
Sciatic Nerve Intraneural Hematoma. 61
31181364 2019
24
Ultrasound-guided treatment of peripheral entrapment mononeuropathies. 61
31093989 2019
25
Electrophysiological findings in immune checkpoint inhibitor-related peripheral neuropathy. 61
31103410 2019
26
Nerve Ultrasonography as an Additive Tool to Clinical Examination and Electrodiagnostics in Sporadic Mononeuritis - Imaging is the Key. 61
31238384 2019
27
Recent Advances in the Understanding and Management of Carpal Tunnel Syndrome: a Comprehensive Review. 61
31372847 2019
28
ULTRASOUND IN THE DIAGNOSIS AND MONITORING OF AMYOTROPHIC LATERAL SCLEROSIS: A REVIEW. 61
30989697 2019
29
Quantitative muscle ultrasound in upper extremity mononeuropathies. 61
30942930 2019
30
Is Triamcinolone an Easy and Efficient Way to Treat Meralgia Paresthetica? A Cohort Study. 61
31359943 2019
31
Primary Neural Leprosy mimicking rheumatological disorders. 61
31340300 2019
32
Compressive Femoral Mononeuropathy Secondary to Acetabular Labral Tear Associated With Paralabral Ganglion Cyst of an Osteoarthritic Hip: A Case Report. 61
31343999 2019
33
A prospective study of high resolution ultrasound in brachial plexopathies - Correlation with electrophysiological measurements. 61
31096121 2019
34
Ischemic Monomelic Neuropathy after Arteriovenous Fistula Surgery: Clinical Features, Electrodiagnostic Findings, and Treatment. 61
31565598 2019
35
Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis. 61
31243320 2019
36
Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain. 61
30904004 2019
37
Bilateral pan-plexus lesion after substance use: A case report. 61
31893280 2019
38
Effective Parameters for Gait Analysis in Experimental Models for Evaluating Peripheral Nerve Injuries in Rats. 61
30653907 2019
39
Retrospective analysis of ocular neuropathies in diabetic dogs following cataract surgery. 61
30095212 2019
40
A delayed diagnosis of eosinophilic granulomatosis with polyangiitis complicated with extensive artery occlusion of lower extremities in children: case report and literature review. 61
31138304 2019
41
Bilateral idiopathic neuralgic amyotrophy involving selective branches of peripheral nerves with a stepwise progression: A case report. 61
31083213 2019
42
Fascicular torsions of the anterior and posterior interosseous nerve in 4 cases: neuroimaging methods to improve diagnosis. 61
31125966 2019
43
Clinical and neurophysiological findings in patients with hereditary neuropathy with liability to pressure palsy and chromosome 17p11.2 deletion. 61
31047731 2019
44
Neuropsychiatric Syndromes in Childhood-Onset Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis. 61
31022053 2019
45
Peroneal nerve mononeuropathy associated with herpes zoster. A case report. 61
30382436 2019
46
Neurological Complications of Cardiac Tumors. 61
30806824 2019
47
Chronic Inflammatory Demyelinating Polyneuropathy. 61
31760654 2019
48
Axillary mononeuropathy after herpes zoster infection misdiagnosed as neuropathic pain. 61
30785247 2019
49
[Mononeuropathy of dorsal interosseous nerve: compression by return radial arteries]. 61
31825378 2019
50
Femoral mononeuropathy in Lyme disease: a case report. 61
31534373 2019

Variations for Mononeuropathy

Expression for Mononeuropathy

Search GEO for disease gene expression data for Mononeuropathy.

Pathways for Mononeuropathy

Pathways related to Mononeuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 TNFRSF1B NGF CD40LG

GO Terms for Mononeuropathy

Cellular components related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 compact myelin GO:0043218 8.62 PMP22 MAG

Biological processes related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.16 MPZ MAG
2 inflammatory response GO:0006954 9.1 TRPV1 TNFRSF1B TAC1 GAL CRP CD40LG
3 negative regulation of heart rate GO:0010459 8.96 TRPV1 TAC1

Sources for Mononeuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....