Aliases & Classifications for Mononeuropathy

MalaCards integrated aliases for Mononeuropathy:

Name: Mononeuropathy 12 15 17
Mononeuropathies 54 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1188
MeSH 43 D020422
SNOMED-CT 67 128189008
ICD10 32 G58.8 G58.9 G59
UMLS 71 C0494491

Summaries for Mononeuropathy

Disease Ontology : 12 A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.

MalaCards based summary : Mononeuropathy, also known as mononeuropathies, is related to mononeuropathy of the median nerve, mild and diabetic neuropathy, and has symptoms including neuralgia An important gene associated with Mononeuropathy is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2), and among its related pathways/superpathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and 14-3-3 and Regulation of BAD Activity. The drugs Pregabalin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Mononeuropathy

Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 523)
# Related Disease Score Top Affiliating Genes
1 mononeuropathy of the median nerve, mild 34.9 SH3TC2 LOC114004390
2 diabetic neuropathy 32.6 TRPV1 PMP22 NGF
3 cranial nerve disease 32.1 TNF PES1 CRP CD40LG
4 carpal tunnel syndrome 31.9 TAC1 SH3TC2 PMP22
5 peroneal nerve paralysis 31.6 PMP22 PES1 HECTD4
6 tarsal tunnel syndrome 31.0 PES1 HECTD4
7 purpura 30.9 TNF CRP CD40LG
8 ulnar neuropathy 30.9 PMP22 ARHGEF10
9 polyarteritis nodosa 30.7 PRTN3 MPO CRP
10 neuritis 30.6 TNF PMP22 MAG
11 vasculitis 30.5 TNFRSF1B TNF PRTN3 MPO CRP CD40LG
12 leprosy 3 30.5 TNF HECTD4 CD40LG
13 anca-associated vasculitis 30.5 PRTN3 MPO
14 tolosa-hunt syndrome 30.5 PRTN3 CRP
15 tibial neuropathy 30.5 PES1 HECTD4
16 neuropathy, hereditary, with liability to pressure palsies 30.5 SH3TC2 PMP22 PES1 MAG
17 radiculopathy 30.5 TAC1 RPL34 PMP22 HECTD4
18 lyme disease 30.4 TNF CRP CD40LG
19 granulomatous angiitis 30.4 PRTN3 CRP
20 endocarditis 30.4 TNFRSF1B TNF CRP
21 churg-strauss syndrome 30.4 TNF PRTN3 MPO CD40LG
22 plexopathy 30.4 RPL34 PMP22 HECTD4 CD40LG
23 facial paralysis 30.3 PRTN3 CRP CD40LG
24 compartment syndrome 30.2 TNF HECTD4 CRP
25 poliomyelitis 30.2 TNF PES1 CD40LG
26 pleurisy 30.2 TNF MPO CRP
27 neurosarcoidosis 30.2 TNFRSF1B TNF CRP
28 subacute bacterial endocarditis 30.1 PRTN3 MPO CRP CD40LG
29 appendicitis 30.1 TNF MPO CRP
30 collagen disease 30.1 TRIM21 CRP CD40LG
31 demyelinating polyneuropathy 30.0 PMP22 NGF MAG
32 polyneuropathy 30.0 TNF SH3TC2 PMP22 NGF MAG CRP
33 antiphospholipid syndrome 30.0 TNF CRP CD40LG
34 systemic scleroderma 30.0 TRIM21 TNF CRP CD40LG
35 sickle cell anemia 30.0 TNF CRP CD40LG
36 herpes zoster 29.9 TRPV1 TNFRSF1B TNF CRP CD40LG
37 arachnoiditis 29.9 TAC1 RPL34 CRP
38 chickenpox 29.9 TNFRSF1B TNF CRP CD40LG
39 ulcerative colitis 29.9 TNF PRTN3 MPO CRP
40 polyradiculoneuropathy 29.9 RPL34 PMP22 MAG
41 sarcoidosis 1 29.9 TNFRSF1B TNF CRP CD40LG
42 diabetic polyneuropathy 29.8 TNF TAC1 NGF ARHGEF10
43 hypersensitivity vasculitis 29.8 TNF PRTN3 MPO CRP CD40LG
44 aspiration pneumonia 29.8 TRPV1 TAC1 CRP CD40LG
45 guillain-barre syndrome 29.7 TNFRSF1B TNF PMP22 MAG CD40LG
46 sialadenitis 29.6 TRIM21 TNF SSB
47 xerophthalmia 29.5 TRIM21 SSB CRP CD40LG
48 granulomatosis with polyangiitis 29.5 TNFRSF1B TNF PRTN3 MPO CRP CD40LG
49 demyelinating disease 29.5 TNF PMP22 NGF MAG CD40LG
50 neuromuscular disease 29.5 SH3TC2 PMP22 PES1 MAG HECTD4 ARHGEF10

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to Mononeuropathy

Symptoms & Phenotypes for Mononeuropathy

UMLS symptoms related to Mononeuropathy:


neuralgia

MGI Mouse Phenotypes related to Mononeuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CD40LG CRP GAL MPO NGF SH3TC2
2 homeostasis/metabolism MP:0005376 9.8 ARHGEF10 CD40LG CRP GAL MAG MPO
3 nervous system MP:0003631 9.36 ARHGEF10 CD40LG GAL MAG NGF PMP22

Drugs & Therapeutics for Mononeuropathy

Drugs for Mononeuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 3 148553-50-8 5486971
2 Hormones Phase 3
3 Anti-Anxiety Agents Phase 3
4 Psychotropic Drugs Phase 3
5 Anticonvulsants Phase 3
6 Analgesics Phase 3
7 Calcium, Dietary Phase 3
8 calcium channel blockers Phase 3
9 Antibodies Phase 3
10 Immunoglobulins, Intravenous Phase 3
11 Rho(D) Immune Globulin Phase 3
12 Immunologic Factors Phase 3
13 gamma-Globulins Phase 3
14 Immunoglobulins Phase 3
15
Calcium Nutraceutical Phase 3 7440-70-2 271
16 Pharmaceutical Solutions Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Multi-center, Randomized, Double-blind, Parallel, Active-controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' and 'Pregabalin' in Peripheral Neuropathic Pain Completed NCT03221907 Phase 3 GLA5PR GLARS-NF1;GLA5PR GLARS-NF1 placebo;Pregabalin;Pregabalin placebo
2 Prospective, Randomised, Placebo-controlled Study of Polyvalent Intravenous Immunoglobulins for the Treatment of Primary Sjögren's Syndrome Associated Painful Sensory Neuropathies Recruiting NCT03700138 Phase 3 Privigen® 100mg/ml at the dose of 2g/kg of body weight;NaCl 0,9%
3 A Multicenter, Randomized, Double-Blind, Placebo and Active Controlled Study Comparing the Analgesic Efficacy and Safety of ABT-639 to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
4 A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Three Doses of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Completed NCT00229437 Phase 2 TAK-128;TAK-128;TAK-128;Placebo
5 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of RWJ 333369 for the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy. Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
6 An Open-Label, Multi-Center Study to Evaluate the Safety of Long-Term Administration of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Terminated NCT00756041 Phase 2 TAK-128
7 A Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Subjects With Postherpetic Neuralgia and Post-traumatic Neuralgia, Followed by a Double Blind Safety Extension and an Open-label Safety Extension Terminated NCT00964990 Phase 2 JNJ-42160443;Placebo
8 Study of Superior Gluteal Mononeuropathy After Total Hip Arthroplasty Through Modified Direct Lateral Approach Unknown status NCT03492684
9 To Investigate the Therapeutic Effect of Aculife Magnetic Therapist on Carpal Tunnel Syndrome Unknown status NCT01277003
10 Predicting Outcome of Transcutaneous Electrical Nerve Stimulator (TENS) in Failed Back Surgery Syndrome Unknown status NCT01185665
11 Role of Sensory Potentials and High-resolution Ultrasonography in Confirmation of Common Peroneal Mononeuropathy at the Fibular Neck Completed NCT03753178
12 Conservative Treatment Versus Ultrasound Guided Injection in Management of Meralgia Paresthetica: A Randomized Controlled Trial Completed NCT04004052
13 Amniotic Membrane Transplantation for Carpal Tunnel Syndrome Treatment: One-year Follow-up Completed NCT04075357
14 Effects of Platelet-rich Plasma in the Surgery of Carpal Tunnel Syndrome: A Randomized Completed NCT03548259
15 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175
16 Neuropathic Pain in Jamaicans With Sickle Cell Disease Recruiting NCT04015401
17 Innovative Ultrasound Technology in Neuromuscular Disease Suspended NCT02104921
18 Effect of Age on the Median Effective Concentration(EC50) for Motor Block With Spinal Plain Bupivacaine Withdrawn NCT02141841

Search NIH Clinical Center for Mononeuropathy

Cochrane evidence based reviews: mononeuropathies

Genetic Tests for Mononeuropathy

Anatomical Context for Mononeuropathy

MalaCards organs/tissues related to Mononeuropathy:

40
Spinal Cord, Brain, Testes, Skin, B Cells, Cortex, Breast

Publications for Mononeuropathy

Articles related to Mononeuropathy:

(show top 50) (show all 1501)
# Title Authors PMID Year
1
Unusual presentation of hereditary neuropathy with liability to pressure palsies. 54 61
18218131 2008
2
Hereditary neuropathy with liability to pressure palsies in infancy. 61 54
12849887 2003
3
DNA rearrangements on both homologues of chromosome 17 in a mildly delayed individual with a family history of autosomal dominant carpal tunnel syndrome. 54 61
9973284 1999
4
Detection of hereditary neuropathy with liability to pressure palsies among patients with acute painless mononeuropathy or plexopathy. 54 61
9843070 1998
5
Takayasu's Arteritis Presenting Atypically in a Female Nigerian. 61
32476124 2020
6
Pathological, ultrasonographic, and electrophysiological characterization of clinically diagnosed cases of pure neuritic leprosy. 61
32250546 2020
7
Meralgia paresthetica: Nerve stimulator-guided injection with methylprednisolone/lidocaine, a double-blind randomized placebo-controlled study. 61
32239737 2020
8
Conservative Treatment Versus Ultrasound-Guided Injection in the Management of Meralgia Paresthetica: A Randomized Controlled Trial. 61
32517391 2020
9
Evaluation of the Scratch Collapse Test for Carpal and Cubital Tunnel Syndrome-A Prospective, Blinded Study. 61
32299690 2020
10
5-HT1A receptor-mediated attenuation of heat hyperalgesia and mechanical allodynia by chrysin in mice with experimental mononeuropathy. 61
32561651 2020
11
Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy. 61
32379362 2020
12
Closed plication is a safe and effective method for treating popliteal venous aneurysm. 61
32446005 2020
13
Risk of carpal tunnel syndrome after parathyroidectomy in patients with end-stage renal disease: A population-based cohort study in Taiwan. 61
32443382 2020
14
Comparison of amniotic membrane transplantation and carpal tunnel syndrome release surgery (CTRS) and CTRS alone: Clinical outcomes at 1-year follow-up. 61
32174033 2020
15
Thrombotic microangiopathy involving kidney allograft and peripheral nerves. 61
31816173 2020
16
Differential gene expression changes in the dorsal root versus trigeminal ganglia following peripheral nerve injury in rats. 61
32100907 2020
17
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study. 61
32362377 2020
18
Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India. 61
32106787 2020
19
Carpal tunnel sonography. 61
32323256 2020
20
Infraspinatus muscle palsy involving suprascapular nerve, brachial plexus or cervical roots related to inflammatory or mechanical causes: Experience of 114 cases. 61
32147283 2020
21
[Cranial mononeuropathy in patients with diabetes mellitus]. 61
32342371 2020
22
Brachial plexus injury after shoulder dislocation: a literature review. 61
29961154 2020
23
[Notalgia paresthetica: Treatment with botulinum toxin type A]. 61
32370829 2020
24
Physical Therapy and Rehabilitation Approaches in Patients with Carpal Tunnel Syndrome. 61
32257712 2020
25
[Polyneuropathies in vasculitis and connective tissue diseases : Clinical manifestations and diagnostic recommendations]. 61
32072188 2020
26
The needle electromyography findings in the neurophysiological classification of ulnar neuropathy at the elbow. 61
32222127 2020
27
Neuromuscular manifestations of lead poisoning in opium and herbal users in Iran. 61
32139183 2020
28
Neuromuscular Mimics of Entrapment Neuropathies of Upper Extremities. 61
32020820 2020
29
Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross-sectional study. 61
31762210 2020
30
Postsurgical Neuropathy: A Descriptive Review. 61
32029088 2020
31
Modern treatment of perineuriomas: a case-series and systematic review. 61
32054523 2020
32
Mid-palm recording technique, a new electrodiagnostic approach in Martin-Gruber anastomosis. 61
32280838 2020
33
Meralgia paresthetica: finding an effective cure. 61
31566048 2020
34
Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. 61
31390162 2020
35
Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice. 61
32457607 2020
36
Pain and small-fiber affection in hereditary neuropathy with liability to pressure palsies (HNPP). 61
31536037 2019
37
Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses. 61
31659433 2019
38
Neurosarcoidosis presenting with a partial Claude syndrome. 61
31748369 2019
39
Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitides: Insights from the DCVAS study. 61
31540965 2019
40
Ultrasound in the diagnosis and management of fibular mononeuropathy. 61
31361339 2019
41
Prospective case series on the use of peripheral nerve stimulation for focal mononeuropathy treatment. 61
31686589 2019
42
Can imaging be the new yardstick for diagnosing peripheral neuropathy?-a comparison between high resolution ultrasound and MR neurography with an approach to diagnosis. 61
31676930 2019
43
Cholecalciferol (Vitamin D3) Reduces Rat Neuropathic Pain by Modulating Opioid Signaling. 61
31001801 2019
44
Ultrasound-Guided Incisionless Carpal Tunnel Release Using a Hook Knife: A Cadaveric Study. 61
30734506 2019
45
Neuromuscular Ultrasound for Peripheral Neuropathies. 61
31639837 2019
46
The usefulness of electrodiagnostic consultation in an outpatient clinic. 61
31227402 2019
47
[Multiple mononeuropathy associated with systemic sclerosis with vasculitis confirmed by nerve biopsy: a case report]. 61
31474645 2019
48
Sciatic Nerve Intraneural Hematoma. 61
31181364 2019
49
Ultrasound-guided treatment of peripheral entrapment mononeuropathies. 61
31093989 2019
50
Recent Advances in the Understanding and Management of Carpal Tunnel Syndrome: a Comprehensive Review. 61
31372847 2019

Variations for Mononeuropathy

Expression for Mononeuropathy

Search GEO for disease gene expression data for Mononeuropathy.

Pathways for Mononeuropathy

Pathways related to Mononeuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 TNFRSF1B TNF NGF CD40LG
2 10.84 TNFRSF1B TNF NGF
3
Show member pathways
10.79 TNFRSF1B TNF NGF CD40LG

GO Terms for Mononeuropathy

Cellular components related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TNF TAC1 PRTN3 NGF MPO GAL
2 extracellular region GO:0005576 9.81 TNFRSF1B TNF TAC1 PRTN3 NGF MPO
3 membrane raft GO:0045121 9.26 TNFRSF1B TNF PRTN3 MAG
4 compact myelin GO:0043218 8.62 PMP22 MAG

Biological processes related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of heart rate GO:0010459 9.26 TRPV1 TAC1
2 inflammatory response GO:0006954 9.17 TRPV1 TNFRSF1B TNF TAC1 GAL CRP
3 negative regulation of lipid storage GO:0010888 9.16 TNF CRP
4 regulation of immunoglobulin secretion GO:0051023 8.96 TNF CD40LG

Sources for Mononeuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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