MCID: MNN017
MIFTS: 45

Mononeuropathy

Categories: Neuronal diseases
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Aliases & Classifications for Mononeuropathy

Summaries for Mononeuropathy

Disease Ontology: 11 A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.

MalaCards based summary: Mononeuropathy, also known as mononeuropathies, is related to purpura and cranial nerve disease, and has symptoms including neuralgia An important gene associated with Mononeuropathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Pregabalin and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and dorsal root ganglion, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: 75 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Mononeuropathy

Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1007)
# Related Disease Score Top Affiliating Genes
1 purpura 30.6 TNF IL6 CRP
2 cranial nerve disease 30.6 TNF IL6 CRP CD4 ALB ACE
3 vasculitis 30.6 TNF PRTN3 MPO IL6 CRP
4 neuropathy, hereditary, with liability to pressure palsies 30.6 SH3TC2 PMP22 MPZ MAG
5 neuropathy 30.6 SH3TC2 PMP22 NGF MPZ ACE
6 diabetic neuropathy 30.5 TRPV1 TAC1 PMP22 NGF MPZ CALCA
7 lesion of sciatic nerve 30.5 TRPV1 SH3TC2 PMP22 NGF
8 hereditary neuropathies 30.4 PMP22 MPZ MAG
9 peroneal neuropathy 30.4 PMP22 MPZ
10 churg-strauss syndrome 30.3 TNF PRTN3 MPO
11 peroneal nerve paralysis 30.3 PRTN3 PMP22
12 plexopathy 30.3 PMP22 MPZ MAG CRP
13 allergic disease 30.2 TNF TAC1 IL6 CD4
14 chronic inflammatory demyelinating polyradiculoneuropathy 30.2 PMP22 MPZ MAG
15 ulnar neuropathy 30.2 PMP22 MPZ
16 radiculopathy 30.2 TAC1 IL6 CRP CALCA
17 lyme disease 30.1 TNF IL6 CRP
18 common cold 30.1 TNF IL6 CRP CD4
19 polyarteritis nodosa 30.1 TNF PRTN3 MPO IL6 CRP
20 proctitis 30.0 TNF MPO CRP
21 pleurisy 30.0 TNF MPO CRP
22 adult respiratory distress syndrome 29.9 TNF MPO IL6 CRP
23 igg4-related disease 29.9 PRTN3 MPO CRP CD4
24 polyradiculoneuropathy 29.8 PMP22 MPZ ALB
25 reflex sympathetic dystrophy 29.8 TRPV1 TAC1 NGF CALCA
26 median neuropathy 29.8 TTR PMP22
27 neuroma 29.8 TRPV1 NGF IL6 CALCA
28 subacute bacterial endocarditis 29.8 PRTN3 MPO CRP ALB
29 guillain-barre syndrome 29.8 TNF PMP22 MPZ ALB
30 neuritis 29.8 TNF PMP22 MPZ MAG IL6
31 cholesterol embolism 29.8 PRTN3 CRP ACE
32 tolosa-hunt syndrome 29.8 PRTN3 CRP ACE
33 leprosy 3 29.8 TNF IL6 CD4 ALB
34 collagen disease 29.8 TRIM21 PRTN3 IL6 CRP
35 gas gangrene 29.7 TNF IL6 CRP ALB
36 sialadenitis 29.7 TRIM21 TNF SSB CD4
37 arachnoiditis 29.7 TNF TAC1 CRP CD4
38 granulomatosis with polyangiitis 29.7 TNF PRTN3 MPO CRP CD4
39 graves disease 1 29.7 CRP CALCA ALB
40 complex regional pain syndrome 29.6 TRPV1 TNF TAC1 NGF IL6 CALCA
41 pulmonary tuberculosis 29.6 TNF IL6 CRP ALB
42 autonomic neuropathy 29.6 TTR NGF ALB
43 compartment syndrome 29.6 TNF IL6 CRP ALB
44 ulcerative colitis 29.6 TNF PRTN3 MPO IL6 CRP
45 causalgia 29.6 TRPV1 TAC1 NGF CALCA
46 mononeuritis multiplex 29.6 TRIM21 TNF SSB PRTN3 MPO MAG
47 carpal tunnel syndrome 29.5 TTR TAC1 SH3TC2 PMP22 MPZ IL6
48 toxic encephalopathy 29.5 TNF NGF IL6 ALB
49 neuromuscular disease 29.5 SH3TC2 PMP22 MPZ MAG ALB
50 polyneuropathy 29.5 TTR SH3TC2 PMP22 NGF MPZ MAG

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to Mononeuropathy

Symptoms & Phenotypes for Mononeuropathy

UMLS symptoms related to Mononeuropathy:


neuralgia

MGI Mouse Phenotypes related to Mononeuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 ACE ALB CALCA CD4 CRP GAL
2 nervous system MP:0003631 10.1 CALCA CD4 GAL IL6 MAG MPZ
3 cardiovascular system MP:0005385 9.97 ACE ALB CALCA CRP GAL IL6
4 immune system MP:0005387 9.77 ACE ALB CD4 CRP IL6 MAG
5 integument MP:0010771 9.32 CALCA CD4 GAL IL6 MPZ NGF

Drugs & Therapeutics for Mononeuropathy

Drugs for Mononeuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 3 148553-50-8 5486971
2 Calcium, Dietary Phase 3
3 Anticonvulsants Phase 3
4 Hormones Phase 3
5 Psychotropic Drugs Phase 3
6 Analgesics Phase 3
7 calcium channel blockers Phase 3
8 Anti-Anxiety Agents Phase 3
9
Calcium Nutraceutical Phase 3 7440-70-2 271
10 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Randomized, Double-blind, Parallel, Active-controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' and 'Pregabalin' in Peripheral Neuropathic Pain Completed NCT03221907 Phase 3 GLA5PR GLARS-NF1;GLA5PR GLARS-NF1 placebo;Pregabalin;Pregabalin placebo
2 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of RWJ 333369 for the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy. Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
3 A Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Subjects With Postherpetic Neuralgia and Post-traumatic Neuralgia, Followed by a Double Blind Safety Extension and an Open-label Safety Extension Terminated NCT00964990 Phase 2 JNJ-42160443;Placebo
4 Study of Superior Gluteal Mononeuropathy After Total Hip Arthroplasty Through Modified Direct Lateral Approach Unknown status NCT03492684
5 Role of Sensory Potentials and High-resolution Ultrasonography in Confirmation of Common Peroneal Mononeuropathy at the Fibular Neck Completed NCT03753178
6 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175
7 Innovative Ultrasound Technology in Neuromuscular Disease Completed NCT02104921
8 Effect of Age on the Median Effective Concentration(EC50) for Motor Block With Spinal Plain Bupivacaine Withdrawn NCT02141841

Search NIH Clinical Center for Mononeuropathy

Cochrane evidence based reviews: mononeuropathies

Genetic Tests for Mononeuropathy

Anatomical Context for Mononeuropathy

Organs/tissues related to Mononeuropathy:

MalaCards : Spinal Cord, Brain, Dorsal Root Ganglion, Skin, Skeletal Muscle, Cingulate Cortex, Cortex

Publications for Mononeuropathy

Articles related to Mononeuropathy:

(show top 50) (show all 1668)
# Title Authors PMID Year
1
Unusual presentation of hereditary neuropathy with liability to pressure palsies. 53 62
18218131 2008
2
Hereditary neuropathy with liability to pressure palsies in infancy. 53 62
12849887 2003
3
DNA rearrangements on both homologues of chromosome 17 in a mildly delayed individual with a family history of autosomal dominant carpal tunnel syndrome. 53 62
9973284 1999
4
Detection of hereditary neuropathy with liability to pressure palsies among patients with acute painless mononeuropathy or plexopathy. 53 62
9843070 1998
5
Dorsal Root Ganglion Stimulation for Lower Extremity Neuropathic Pain Syndromes: An Evidence-Based Literature Review. 62
35994195 2022
6
Diabetic Mononeuropathies and Diabetic Amyotrophy. 62
35969368 2022
7
Clinical Reasoning: A 39-Year-Old Man With Asymmetric Distal Weakness and Loss of Sensitivity. 62
36257711 2022
8
[Peripheral neuropathies and factors associated in chronic hemodialysis patients in Benin]. 62
36163234 2022
9
Not so Shocking: Electromyography in Pediatrics Remains Feasible and Diagnostically Useful. 62
34392843 2022
10
Bilateral peroneal nerve palsy secondary to prolonged sitting in an adolescent patient. 62
33175582 2022
11
Bilateral peroneal nerve palsy due to prolonged squatting in farmers: clinical and electrophysiological outcome. 62
36111735 2022
12
Clinical and electrophysiological characteristics of neuropathic pain in leprosy patients: A prospective cross-sectional study. 62
34951937 2022
13
Primary Sjögren syndrome-related peripheral neuropathy: A systematic review and meta-analysis. 62
36086910 2022
14
Mepolizumab administration for eosinophilic granulomatosis with polyangiitis in an elderly patient with abrupt onset of limb ischemia and peripheral neuropathy: A case-based literature review. 62
36107735 2022
15
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy. 62
35972460 2022
16
Cryolipolysis-associated radial mononeuropathy. 62
35621077 2022
17
Ultrasonography for carpal tunnel syndrome in pregnancy: a prospective cross-sectional study. 62
35260035 2022
18
A Comparison of Nerve-Specific, Condition-Specific, and Upper Extremity-Specific Patient-Reported Outcome Measures in Patients With Carpal and Cubital Tunnel Syndrome. 62
34452799 2022
19
Prevalence of function-limiting late effects in Hodgkin lymphoma survivors. 62
34181821 2022
20
Anterolateral Thigh Flap for Low-Voltage Fourth-Degree Electrical Burn Injury With Immediate Radial Nerve Palsy at the Elbow: A Case Report. 62
35352816 2022
21
Peripheral neuropathy and livedoid vasculopathy. 62
35166926 2022
22
Ischiofemoral impingement syndrome provoked by labor: An unusual case of complete sciatic mononeuropathy. 62
35723073 2022
23
Successful Management of Meralgia Paresthetica by Hydro Dissection in a Middle-Aged Male: A Case Report. 62
35855224 2022
24
[Acute sarcoid myopathy and neuropathy aggravated by ustekinumab administration in an elderly woman with psoriasis and systemic sarcoidosis]. 62
35644583 2022
25
Devastating ischemic dimelic neuropathy after plastic zip tie handcuffs; message for security agencies. 62
35734656 2022
26
Multifocal Motor Neuropathy With Cranial Nerve Involvement and Vocal Cord Paralysis: A Case Report. 62
35746993 2022
27
Lateral Antebrachial Cutaneous Neuropathy: A Review of 15 Cases. 62
35747042 2022
28
Does specificity of electrodiagnostic test referrals predict test outcome in children? 62
35119698 2022
29
Anatomical Analysis of the Lateral Femoral Cutaneous Nerve and Its Passage beneath the Inguinal Ligament. 62
35271552 2022
30
Childhood focal compressive mononeuropathies during the COVID-19 pandemic in Buenos Aires, Argentina. 62
35083751 2022
31
A 17-year-old boy who presented with acute mononeuropathy was found to have Type 1 diabetes. 62
35389821 2022
32
Clinical and neurophysiological findings in patients with hereditary neuropathy with liability to pressure palsy and chromosome 17p11.2 deletion. 62
35595399 2022
33
Neurosarcoidosis: A Case Report. 62
35651406 2022
34
Peripheral Neuropathy in Patients Recovering from Severe COVID-19: A Case Series. 62
35454362 2022
35
Isolated Proximal Median Neuropathy after Aortic Dissection Repair: Case Report. 62
35630039 2022
36
[First clinical manifestation of chronic hepatitis C in painless progressive atrophic monoparesis of the right leg]. 62
35545070 2022
37
[Neurological shoulder pain and weakness : practical attitudes]. 62
35481503 2022
38
Risk factors of asymptomatic reduction of motor conduction velocity of the ulnar nerve across the elbow. 62
34499243 2022
39
Peripheral neurological complications during COVID-19: A single center experience. 62
34971857 2022
40
Progressive Multiple Mononeuropathy in a Patient With Familial Transthyretin Amyloidosis After Liver Transplantation. 62
35188911 2022
41
Neurological safety of subcutaneous tanezumab versus NSAID in patients with osteoarthritis. 62
35217440 2022
42
Ultrasound-guided percutaneous carpal tunnel release: A systematic review. 62
35254722 2022
43
Neuromodulation in the Treatment of Painful Diabetic Neuropathy: A Review of Evidence for Spinal Cord Stimulation. 62
34842478 2022
44
Ultrasound-Guided Pulsed Radiofrequency Treatment for Meralgia Paresthetica. 62
35282534 2022
45
COVID-19 associated cranial nerve neuropathy: A systematic review. 62
34392827 2022
46
Neurological impact of eosinophilic granulomatosis with polyangiitis. 62
33905106 2022
47
Palliative surgery for foot drop. 62
34571208 2022
48
Clinical and pathological findings in neurolymphomatosis: Preliminary association with gene expression profiles in sural nerves. 62
36226068 2022
49
Ultrasound-Guided Lateral Pectoral Nerve Pulsed Radiofrequency in a Patient With Refractory Pectoral Pain: A Case Report of a Novel Approach. 62
35242465 2022
50
Lower limb axonal mononeuropathies as sequelae of COVID-19: a case report and review of literature. 62
35194370 2022

Variations for Mononeuropathy

Expression for Mononeuropathy

Search GEO for disease gene expression data for Mononeuropathy.

Pathways for Mononeuropathy

GO Terms for Mononeuropathy

Cellular components related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 ACE ALB CALCA CRP GAL IL6
2 extracellular space GO:0005615 9.7 TTR TNF TAC1 PRTN3 NGF MPO
3 compact myelin GO:0043218 9.46 PMP22 MAG

Biological processes related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to nerve growth factor stimulus GO:1990090 9.8 TRPV1 TAC1 CALCA
2 inflammatory response GO:0006954 9.77 TRPV1 TNF TAC1 IL6 GAL CRP
3 response to gold nanoparticle GO:1990268 9.56 TNF MPO
4 response to pain GO:0048265 9.55 TRPV1 TAC1 CALCA
5 negative regulation of lipid storage GO:0010888 9.1 TNF IL6 CRP

Molecular functions related to Mononeuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.23 TNF PRTN3 NGF MAG IL6 CALCA

Sources for Mononeuropathy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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