Mononeuropathy of the Median Nerve, Mild disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MNMN MCID: MNN028 MIFTS: 53	Mononeuropathy of the Median Nerve, Mild (MNMN) Categories: Genetic diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Mononeuropathy of the Median Nerve, Mild

MalaCards integrated aliases for Mononeuropathy of the Median Nerve, Mild:

Name: Mononeuropathy of the Median Nerve, Mild ⁵⁷ ¹² ³⁸ ⁷¹

Carpal Tunnel Syndrome ⁵⁷ ⁷³ ⁷¹

Susceptibility to Mononeuropathy of the Median Nerve, Mild ²⁸ ⁵

Mnmn ⁵⁷ ⁷³

Carpal Tunnel Syndrome, Susceptibility to ⁵⁷

Mononeuropathy of the Median Nerve Mild ⁷³

Characteristics:

Inheritance:

Autosomal dominant ⁵⁷

OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Miscellaneous:
allelic disorder to autosomal recessive charcot-marie-tooth disease type 4c

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 613353

MeSH ⁴³ D002349

MedGen ⁴⁰ C3150596

SNOMED-CT via HPO ⁶⁹ 128189008 128208007 302226006 more

UMLS ⁷¹ C0007286 C3150596

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Summaries for Mononeuropathy of the Median Nerve, Mild

UniProtKB/Swiss-Prot: ⁷³ A disease characterized by median nerve mononeuropathy at the wrist. The clinical presentation ranges from a mild phenotype, consistent with carpal tunnel syndrome, to a severe median nerve mononeuropathy at the wrist associated with evidence of a more widespread axonal polyneuropathy. The latter phenotype is similar to that of patients with hereditary neuropathy with liability to pressure palsies.

MalaCards based summary: Mononeuropathy of the Median Nerve, Mild, also known as carpal tunnel syndrome, is related to carpal tunnel syndrome and carpal tunnel syndrome 2, and has symptoms including tremor, back pain and headache. An important gene associated with Mononeuropathy of the Median Nerve, Mild is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2). The drugs Gabapentin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone, and related phenotypes are polyneuropathy and constrictive median neuropathy

More information from OMIM: 613353

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Related Diseases for Mononeuropathy of the Median Nerve, Mild

Diseases related to Mononeuropathy of the Median Nerve, Mild via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)

#	Related Disease	Score
1	carpal tunnel syndrome	12.4
2	carpal tunnel syndrome 2	11.8
3	neuropathy, hereditary, with liability to pressure palsies	11.6
4	amyloidosis, hereditary, transthyretin-related	11.5
5	paresthesia	11.4
6	amyloidosis	11.4
7	peripheral nervous system disease	11.4
8	chromosome 1q21.1 duplication syndrome	11.3
9	radiculopathy	11.3
10	acromegaly	11.3
11	scheie syndrome	11.3
12	temporal arteritis	11.3
13	dialysis-related amyloidosis	11.3
14	mucopolysaccharidosis, type ii	11.3
15	wild type abeta2m amyloidosis	11.3
16	mucolipidosis iii gamma	11.2
17	repetitive motion disorders	11.2
18	nerve compression syndrome	11.2
19	acromicric dysplasia	11.2
20	mucopolysaccharidosis, type vi	11.2
21	mucopolysaccharidosis, type vii	11.2
22	rhizomelic pseudopolyarthritis	11.2
23	localized lichen myxedematosus with monoclonal gammopathy or systemic symptoms	11.2
24	neuropathy	11.1
25	tenosynovitis	11.0
26	polyneuropathy	10.9
27	mononeuropathy	10.9
28	median neuropathy	10.8
29	hypothyroidism	10.8
30	gout	10.8
31	slowed nerve conduction velocity, autosomal dominant	10.8
32	mucopolysaccharidosis-plus syndrome	10.8
33	raynaud disease	10.7
34	synovitis	10.7
35	body mass index quantitative trait locus 1	10.7
36	ulnar neuropathy	10.7
37	diabetic polyneuropathy	10.7
38	neuromuscular disease	10.7
39	lipomatosis, multiple	10.7
40	osteoarthritis	10.6
41	mucopolysaccharidoses	10.6
42	paine syndrome	10.6
43	rapidly involuting congenital hemangioma	10.6
44	complex regional pain syndrome	10.6
45	arthropathy	10.6
46	macrodactyly	10.6
47	microvascular complications of diabetes 1	10.6
48	tendinitis	10.6
49	systemic scleroderma	10.6
50	muscular atrophy	10.6

Comorbidity relations with Mononeuropathy of the Median Nerve, Mild via Phenotypic Disease Network (PDN):

Deficiency Anemia	Diabetic Polyneuropathy
Hypertension, Essential	Hypothyroidism
Intermediate Coronary Syndrome	Rheumatoid Arthritis
Transient Cerebral Ischemia	Ulnar Nerve Lesion

Graphical network of the top 20 diseases related to Mononeuropathy of the Median Nerve, Mild:

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Symptoms & Phenotypes for Mononeuropathy of the Median Nerve, Mild

Human phenotypes related to Mononeuropathy of the Median Nerve, Mild:

³⁰

#	Description	HPO Source Accession
1	polyneuropathy ³⁰	HP:0001271
2	constrictive median neuropathy ³⁰	HP:0012185
3	peripheral axonal neuropathy ³⁰	HP:0003477
4	mononeuropathy ³⁰	HP:0009831

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Neurologic Peripheral Nervous System:
carpal tunnel syndrome
mononeuropathy of the median nerve
more widespread axonal polyneuropathy may occur
patchy axonal neuropathy

Clinical features from OMIM®:

613353 (Updated 08-Dec-2022)

UMLS symptoms related to Mononeuropathy of the Median Nerve, Mild:

tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; muscle cramp

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Drugs & Therapeutics for Mononeuropathy of the Median Nerve, Mild

Drugs for Mononeuropathy of the Median Nerve, Mild (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Nimodipine

Approved, Investigational

Phase 4

66085-59-4

4497

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Vancomycin

Approved

Phase 4

1404-90-6

14969

Cefazolin

Approved

Phase 4

25953-19-9

33255

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

581 12035

Povidone K30

Approved, Experimental, Withdrawn

Phase 4

9003-39-8

6917 131751496

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Acetaminophen

Approved

Phase 4

103-90-2

1983

Cathine

Approved, Experimental, Illicit, Vet_approved, Withdrawn

Phase 4

14838-15-4, 492-39-7

131954576 4786 26934

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Arginine

Approved, Investigational, Nutraceutical

Phase 4

74-79-3

6322

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

22737-96-8, 68-26-8

5280382 445354

Lipoic acid

Approved, Investigational, Nutraceutical

Phase 4

1200-22-2

864 6112

Cysteine

Approved, Nutraceutical

Phase 4

52-90-4

594 5862

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Ibuprofen arginine

Phase 4

Retinol palmitate

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Diuretics, Potassium Sparing

Phase 4

Alpha-lipoic Acid

Phase 4

Anti-Anxiety Agents

Phase 4

Psychotropic Drugs

Phase 4

Anticonvulsants

Phase 4

Antibiotics, Antitubercular

Phase 4

Anti-Bacterial Agents

Phase 4

Ketorolac Tromethamine

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Immunologic Factors

Phase 4

Protective Agents

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Neuroprotective Agents

Phase 4

Antiemetics

Phase 4

Gastrointestinal Agents

Phase 4

Epinephryl borate

Phase 4

Pharmaceutical Solutions

Phase 4

Triamcinolone hexacetonide

Phase 4

Triamcinolone diacetate

Phase 4

Interventional clinical trials:

(show top 50) (show all 353)

#	Name	Status	NCT ID	Phase	Drugs
1	Pain Reduction and Changes in Upper Limb Function Produced by Over the Counter Oral Ibuprofen Versus the Lack of Treatment, in Carpal Tunnel Syndrome.	Unknown status	NCT04328805	Phase 4	Ibuprofen tablets
2	Pain Reduction Produced by Physiotherapy, Ibuprofen, and the Absence of Treatment, in Carpal Tunnel Syndrome	Unknown status	NCT04119739	Phase 4	Ibuprofen
3	A Prospective, Randomized, Double-Blind, Cross-over Study of Lidocaine Patch 1.8% in Patients With Moderate to Severe Pain From Carpal Tunnel Syndrome	Unknown status	NCT04245371	Phase 4	Lidocaine 1.8%;Placebo
4	Oral Gabapentin Versus Control in the Treatment of Carpal Tunnel Syndrome	Unknown status	NCT04285281	Phase 4	Gabapentin oral capsules
5	Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration: Clinical Randomized Trial	Unknown status	NCT03196817	Phase 4	betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
6	Pain Reduction and Changes in Upper Limb Function Produced by Physiotherapy, Ibuprofen Arginine, Gabapentin and the Absence of Treatment, in Carpal Tunnel Syndrome	Unknown status	NCT04025203	Phase 4	Ibuprofen Arginine;Gabapentin
7	A Prospective Randomized Controlled Clinical Trial Comparing the Extracorporeal Shock Wave and Local Corticosteroid Injection for Carpal Tunnel Syndrome	Completed	NCT04767724	Phase 4
8	Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial	Completed	NCT02140632	Phase 4
9	Randomised, Multicentre, Open Label, Parallel Group Pragmatic Clinical Trial of Local Steroid Injection Versus Night Splinting in Mild to Moderate Carpal Tunnel Syndrome (CTS)	Completed	NCT02038452	Phase 4	Depo-Medrone
10	The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial.	Completed	NCT01895621	Phase 4
11	Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome	Completed	NCT03802448	Phase 4
12	Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial	Completed	NCT03792945	Phase 4	local injection
13	Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome	Completed	NCT02652390	Phase 4	Methylprednisolone 80 mg;Methylprednisolone 40 mg
14	Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome (Cts): A Randomized, Placebo-Controlled Trial With Secondary Bayesian Modification	Completed	NCT00277563	Phase 4
15	Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters	Completed	NCT00678314	Phase 4	Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
16	A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions	Completed	NCT00904202	Phase 4	Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
17	Onset and Duration of Forearm Nerve Blockade Performed With a Single Distal Injection Versus Sequential Injections at Distal and Proximal Locations Alongside the Nerves: A Blinded Randomized	Completed	NCT03649763	Phase 4	Lidocaine;Bupivacaine
18	Length of Postoperative Dressing After Mini-open Carpal Tunnel Release: A Randomized Prospective Comparison	Completed	NCT01310218	Phase 4
19	Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial	Completed	NCT01751347	Phase 4	Bupivacaine;Lidocaine
20	Endoscopic Carpal Tunnel Release, Infection Incidence, and Prophylactic Antibiotics: Indicated or Kick the Habit?	Completed	NCT03432858	Phase 4	Vancomycin;Cefazolin;Saline Solution
21	A Randomized, Controlled Trial Comparing Combination Therapy of Ibuprofen + Acetaminophen Versus Hydrocodone + Acetaminophen for the Treatment of Pain After Carpal Tunnel Surgery	Completed	NCT01974609	Phase 4	Narcotic;non-narcotic
22	Comparing Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol Administration for Carpal Tunnel Release and Distal Radius Fracture Surgeries	Completed	NCT02313675	Phase 4	Acetaminophen;Ketorolac Tromethamine;Saline
23	The NOR-CACTUS Trial - A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome	Recruiting	NCT05306548	Phase 4	Injection, Triamcinolone Hexacetonide
24	The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial	Recruiting	NCT04460521	Phase 4	N-Acetyl cysteine
25	Comparison of the Efficacy of Different Treatment Methods in Patients With Carpal Tunnel Syndrome	Recruiting	NCT05475808	Phase 4	Wrist local steroid injection
26	The Therapeutic Effect and Quality of Life After Local Injection of Steroid VS. Glucose 5% for Carpal Tunnel Syndrome : Double-blinded Clinical Trial	Recruiting	NCT05496764	Phase 4	Dexamethasone;Glucose Injection
27	Randomized Controlled Trial of Ultrasound-guided Steroid Injection Versus Wrist Splint in Patients With Carpal Tunnel Syndrome	Recruiting	NCT04515966	Phase 4	Methylprednisolone Injection [Solu-Medrol]
28	Exparel and Education to Avoid Opioids After Carpal Tunnel Release	Recruiting	NCT03867539	Phase 4
29	Satisfaction With Pain Relief After Carpal Tunnel Release Surgery	Terminated	NCT01588158	Phase 4	Acetaminophen;Vicodin
30	The Effect of Theraworx Foam on the Cross-sectional Area of the Median Nerve in Patients With Carpal Tunnel Syndrome	Withdrawn	NCT04017390	Phase 4	Theraworx Foam;Placebo Foam
31	Ultrasound-guided PRP Versus Steroid Injections in Management of Carpal Tunnel Syndrome; a Comparative Study	Unknown status	NCT04434105	Phase 2, Phase 3	platlet rich plasma (PRP);Triamcinolone Acetonide;Saline
32	Comparison of Local Steroid Injection With Platelet Rich Plasma in the Treatment of Carpal Tunnel Syndrome	Unknown status	NCT04000932	Phase 3	Local platelet rich plasma (PRP) injection-T-Lab PRP kit;Local steroid injection-Diprospan ®, Schering Plough
33	Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome	Unknown status	NCT02870673	Phase 2, Phase 3	SHINCORT;XYLOCAINE
34	Comparison Results of Carpal Tunnel Release Between Standard Incision and Limited Incision Using PSU Retractor: A Randomized Controlled Trial	Unknown status	NCT01017471	Phase 3
35	Sonography-guided Steroid Injection for Carpal Tunnel Syndrome	Completed	NCT02575729	Phase 3	betamethasone
36	Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial.	Completed	NCT02141035	Phase 2, Phase 3	Acetyl-l-carnitine;placebo
37	Local Steroid Injection in the Treatment of Idiopathic Carpal Tunnel Syndrome: A Randomized Double-blind Placebo-controlled Trial Among Patients Planned for Surgical Treatment	Completed	NCT00806871	Phase 2, Phase 3	Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
38	Gabapentin for Carpal Tunnel Syndrome: A Randomised Controlled Trial	Completed	NCT00137735	Phase 3	Gabapentin
39	Effect of Preoperative Gabapentine for Carpal Tunnel Syndrome	Completed	NCT01632215	Phase 3	Gabapentine
40	The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study - A Single Site, Non-inferiority Randomised Control Trial Evaluating Pain After Soft Tissue Corticosteroid Injections With and Without Local Anaesthetic	Recruiting	NCT04253457	Phase 3	1ml of triamcinolone (40mg/1ml)
41	A Randomized, Double-Blind Study Comparing the Safety and Efficacy of the Lidocaine Patch 5% With Placebo in Patients With Pain From Carpal Tunnel Syndrome	Terminated	NCT00266214	Phase 3	lidocaine patch 5%
42	NeuroPath Comparative Validation Study Plan	Terminated	NCT00393549	Phase 3
43	A Phase III, Randomized, Open-label Study to Assess the Safety and Efficacy of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Minor Surgical Procedures	Terminated	NCT00209560	Phase 3	fospropofol disodium
44	Carpal Tunnel Syndrome and Static Magnetic Field Therapy	Unknown status	NCT00521495	Phase 2
45	Instiutional Review Board of Chung Shan Medical University Hospital	Unknown status	NCT00514462	Phase 1, Phase 2
46	Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome: a Preliminary Study.	Completed	NCT00634699	Phase 1, Phase 2
47	Treatment Efficacy of OMT for Carpal Tunnel Syndrome	Completed	NCT00394043	Phase 2
48	Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome, a Preliminary Study	Completed	NCT00634738	Phase 1, Phase 2
49	BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome	Completed	NCT02070302	Phase 2	Botulinum Toxin Type A;Placebo
50	A Controlled Trial of Acupuncture for Carpal Tunnel Syndrome	Completed	NCT00000394	Phase 2

Search NIH Clinical Center for Mononeuropathy of the Median Nerve, Mild

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Genetic Tests for Mononeuropathy of the Median Nerve, Mild

Genetic tests related to Mononeuropathy of the Median Nerve, Mild:

#	Genetic test	Affiliating Genes
1	Susceptibility to Mononeuropathy of the Median Nerve, Mild ²⁸	SH3TC2

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Anatomical Context for Mononeuropathy of the Median Nerve, Mild

Organs/tissues related to Mononeuropathy of the Median Nerve, Mild:

MalaCards : Skin, Brain, Bone, Spinal Cord, Breast, Thyroid, Cortex

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Publications for Mononeuropathy of the Median Nerve, Mild

Articles related to Mononeuropathy of the Median Nerve, Mild:

(show top 50) (show all 9430)

#	Title	Authors	PMID	Year
1	Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. ⁶² ⁵⁷ ⁵	Lupski JR...Gibbs RA	20220177	2010
2	Mutational screening of the SH3TC2 gene in Greek patients with suspected demyelinating recessive Charcot-Marie-Tooth disease reveals a varied and unusual phenotypic spectrum. ⁵	Kontogeorgiou Z...Koutsis G	30653784	2019
3	The cerebellar phenotype of Charcot-Marie-Tooth neuropathy type 4C. ⁵	Skott H...Paucar M	31346473	2019
4	Screening for SH3TC2 gene mutations in a series of demyelinating recessive Charcot-Marie-Tooth disease (CMT4). ⁵	Piscosquito G...Pareyson D	27231023	2016
5	Phenotypic variability of CMT4C in a French-Canadian kindred. ⁵	Varley TL...Baker SK	25737037	2015
6	Clinical exome sequencing for genetic identification of rare Mendelian disorders. ⁵	Lee H...Nelson SF	25326637	2014
7	Genetic diagnosis of Charcot-Marie-Tooth disease in a population by next-generation sequencing. ⁵	Hoyer H...Russell MB	25025039	2014
8	Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy. ⁵	Lupski JR...Gibbs RA	23806086	2013
9	The phenotype of Charcot-Marie-Tooth disease type 4C due to SH3TC2 mutations and possible predisposition to an inflammatory neuropathy. ⁵	Houlden H...Reilly MM	19272779	2009
10	Founder SH3TC2 mutations are responsible for a CMT4C French-Canadians cluster. ⁵	Gosselin I...Brais B	18511281	2008
11	Spine deformities in Charcot-Marie-Tooth 4C caused by SH3TC2 gene mutations. ⁵	Azzedine H...LeGuern E	16924012	2006
12	Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. ⁵	Senderek J...Zerres K	14574644	2003
13	Fibrolipomatous hamartoma with macrodactyly and carpal tunnel syndrome. ⁶²	Saida T...Nakajima T	36411853	2023
14	Shear wave elastography is a valuable tool for diagnosing and grading carpal tunnel syndrome. ⁶²	Sernik RA...Leao RV	35920932	2023
15	Repeatability, Reproducibility and Sources of Variability in the Assessment of Backscatter Coefficient and Texture Parameters from High-Frequency Ultrasound Acquisitions in Human Median Nerve. ⁶²	Wu Y...Shah SB	36283940	2023
16	The distance between the distal margin of the flexor retinaculum and the radiocarpal joint as a landmark in CTS surgery: A cadaver study. ⁶²	Krigers A...Fritsch H	36183941	2023
17	Repair of severed recurrent thenar branch of median nerve after open carpal tunnel release. ⁶²	Kang DH...Kim JD	36148020	2022
18	Application of an Improved U2-Net Model in Ultrasound Median Neural Image Segmentation. ⁶²	Shao J...Geng DY	36167742	2022
19	Is the outcome of a revision carpal tunnel release as good as those of a primary release? A matched cohort study. ⁶²	Ten Heggeler MA...Hand-Wrist Study Group	36272920	2022
20	Neuropathic upper extremity pain: A double-crush scenario. ⁶²	Worthley E	36412937	2022
21	Association of Economic Well-Being With Comorbid Conditions in Patients Undergoing Carpal Tunnel Release. ⁶²	Zhang D...Blazar P	34716055	2022
22	Patient Concerns About Wide-Awake Local Anesthesia No Tourniquet (WALANT) Hand Surgery. ⁶²	Morris MT...Wall LB	34774346	2022
23	Deep CTS: a Deep Neural Network for Identification MRI of Carpal Tunnel Syndrome. ⁶²	Zhou H...Lu H	35661280	2022
24	Comparison of ultrasound-guided pulsed radiofrequency versus steroid injection in the treatment of carpal tunnel syndrome. ⁶²	Celenlioglu AE...Guler G	35129753	2022
25	Contribution of imaging to preoperative work-up for persistent carpal tunnel syndrome. ⁶²	Matter-Parrat V...Lussiez B	36089215	2022
26	A Quality Collaborative Study of the Concordance of Electrodiagnostic Scores and Clinical Severity in Carpal Tunnel Syndrome. ⁶²	Billig JI...Michigan Collaborative Hand Initiative for Quality in Surgery Collaborators	36112828	2022
27	Factors affecting contralateral wrist surgery after one carpal tunnel release in bilateral carpal tunnel syndrome. ⁶²	Lee JK...Han SH	36150692	2022
28	Understanding carpal tunnel syndrome. ⁶²	Garcia JO...Turkmani A	36346923	2022
29	Comparison of Distal and Proximal Local Steroid Injection for Carpal Tunnel Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials. ⁶²	Dong C...Hu L	36197649	2022
30	Ultrasound-based radiomics in the diagnosis of carpal tunnel syndrome: The influence of regions of interest delineation method on mode. ⁶²	Lyu S...Zhang B	36341718	2022
31	Fibrolipomatous hamartoma of the median nerve in a child with carpal tunnel syndrome: imaging findings and literature review. ⁶²	Paolantonio G...Toma P	36418537	2022
32	A 60-Year-Old Woman with Symptoms of Combined Carpal Tunnel Syndrome and Cubital Tunnel Syndrome Due to an Elastofibroma Causing Compression of the Median and Ulnar Nerves. ⁶²	Sibira RM...Muneer M	36419329	2022
33	Has the Use of Electrodiagnostic Studies for Carpal Tunnel Syndrome Changed After the 2016 American Academy of Orthopaedic Surgeons Clinical Practice Guideline? ⁶²	Zhuang T...Kamal RN	36460552	2022
34	[Amyloid arthropathy and the carpal tunnel syndrome: report of a case]. ⁶²	Gong LH...Sun X	36323556	2022
35	Pseudogout: A Rare Cause of Acute Carpal Tunnel Syndrome and Acute Guyon Canal Syndrome. ⁶²	Rackard F...Rothkopf D	36425382	2022
36	Clinical Relevance of Ultrasonographic and Electrophysiological Findings of the Median Nerve in Unilateral Carpal Tunnel Syndrome Patients. ⁶²	Kudo T...Ishii T	36428858	2022
37	Incidence of Carpal Tunnel Syndrome after Distal Radius Fracture. ⁶²	Cooke ME...Fufa DT	36425367	2022
38	Carpal Tunnel Syndrome in the Setting of Ulnar Dysmelia. ⁶²	Milam RJ...Ghidella SD	36425379	2022
39	Impaired median nerve mobility in patients with carpal tunnel syndrome: a systematic review and meta-analysis. ⁶²	Lin MT...Wu CH	36394604	2022
40	Work-relatedness of carpal tunnel syndrome: Systematic review including meta-analysis and GRADE. ⁶²	Hassan A...van der Molen HF	36340637	2022
41	A preliminary study of radioulnar wrist compression in improving patient-reported outcomes of carpal tunnel syndrome. ⁶²	Li ZM...Kwoh CK	36352375	2022
42	Carpal tunnel syndrome secondary to tumoral calcinosis: a case report and review of the literature. ⁶²	Abdallah M...Hoyek F	36348303	2022
43	Ultrasound Findings in Patients with Normal Nerve Conduction despite Clinical Signs and Symptoms Consistent with Carpal Tunnel Syndrome. ⁶²	Chen J...Fowler JR	35998137	2022
44	Carpal tunnel mechanics and its relevance to carpal tunnel syndrome. ⁶²	Li ZM...Jordan DB	36442295	2022
45	Digital Skin Ulceration and Acro-Osteolysis: A Rare Presentation of Severe Carpal Tunnel Syndrome. ⁶²	Zorlu O...Karabag S	36386731	2022
46	Ultrasound of the Median Nerve in the Surgical Treatment of Severe Carpal Tunnel Syndrome. ⁶²	Melton W...Ho D	33487036	2022
47	Complex trigger wrist associated with carpal tunnel syndrome: a case report. ⁶²	Lychagin AV...Ponomarev AB	36371272	2022
48	A Retrospective Clinical Study of Endoscopic Treatment of Carpal Tunnel Syndrome using the Modified Soft Tissue Release kit. ⁶²	Li Y...Dai K	36414546	2022
49	VOLCON: a randomized controlled trial investigating complications and functional outcome of volar plating vs casting of unstable distal radius fractures in patients older than 65 years. ⁶²	Thorninger R...Rolfing JD	36443579	2022
50	Red flags in patients with hereditary transthyretin amyloidosis at diagnosis in a non-endemic area of Spain. ⁶²	Silva-Hernandez L...Galan Davila L	36396096	2022

Sources

Genes for Mononeuropathy of the Median Nerve, Mild

Genes related to Mononeuropathy of the Median Nerve, Mild (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SH3TC2	SH3 Domain And Tetratricopeptide Repeats 2	Protein Coding	1333.23	Molecular basis known ⁵⁷ Pathogenic ⁵ Causative variation ⁷³ Genetic Tests ²⁸ Likely pathogenic ⁵ GeneCards inferred via : Disorders (show sections)	14574644 16924012 18511281 (more) 19272779 20220177 31346473 30653784 27231023 25737037 25326637 25025039 23806086

Sources

Variations for Mononeuropathy of the Median Nerve, Mild

ClinVar genetic disease variations for Mononeuropathy of the Median Nerve, Mild:

⁵ (show top 50) (show all 538)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	SH3TC2	NM_024577.4(SH3TC2):c.2860C>T (p.Arg954Ter)	SNV	Pathogenic Pathogenic	2482	rs80338933	GRCh37: 5:148406435-148406435 GRCh38: 5:149026872-149026872
2	SH3TC2	NM_024577.4(SH3TC2):c.1972C>T (p.Arg658Cys)	SNV	Likely Pathogenic	21690	rs80338926	GRCh37: 5:148407323-148407323 GRCh38: 5:149027760-149027760
3	SH3TC2	NM_024577.4(SH3TC2):c.3512G>A (p.Arg1171His)	SNV	Uncertain Significance	952984	rs200728983	GRCh37: 5:148386607-148386607 GRCh38: 5:149007044-149007044
4	SH3TC2	NM_024577.4(SH3TC2):c.1431G>A (p.Glu477=)	SNV	Uncertain Significance	476884	rs887057321	GRCh37: 5:148407864-148407864 GRCh38: 5:149028301-149028301
5	SH3TC2	NM_024577.4(SH3TC2):c.79A>G (p.Thr27Ala)	SNV	Uncertain Significance	220296	rs141649676	GRCh37: 5:148431777-148431777 GRCh38: 5:149052214-149052214
6	SH3TC2, LOC114004390	NM_024577.3(SH3TC2):c.-77C>T	SNV	Uncertain Significance	906669	rs1017906109	GRCh37: 5:148442662-148442662 GRCh38: 5:149063099-149063099
7	SH3TC2	NM_024577.4(SH3TC2):c.3686A>T (p.Asp1229Val)	SNV	Uncertain Significance	188089	rs146920285	GRCh37: 5:148384455-148384455 GRCh38: 5:149004892-149004892
8	SH3TC2	NM_024577.4(SH3TC2):c.2812C>T (p.His938Tyr)	SNV	Uncertain Significance	448368	rs144688852	GRCh37: 5:148406483-148406483 GRCh38: 5:149026920-149026920
9	SH3TC2	NM_024577.4(SH3TC2):c.3413G>A (p.Ser1138Asn)	SNV	Uncertain Significance	407264	rs150805608	GRCh37: 5:148388479-148388479 GRCh38: 5:149008916-149008916
10	SH3TC2	NM_024577.4(SH3TC2):c.2304C>T (p.Leu768=)	SNV	Uncertain Significance	220505	rs140829706	GRCh37: 5:148406991-148406991 GRCh38: 5:149027428-149027428
11	SH3TC2	NM_024577.4(SH3TC2):c.1767C>T (p.Ser589=)	SNV	Uncertain Significance	390930	rs139898175	GRCh37: 5:148407528-148407528 GRCh38: 5:149027965-149027965
12	SH3TC2	NM_024577.4(SH3TC2):c.830C>T (p.Thr277Met)	SNV	Uncertain Significance	543415	rs757969875	GRCh37: 5:148418029-148418029 GRCh38: 5:149038466-149038466
13	SH3TC2	NM_024577.4(SH3TC2):c.751C>T (p.Pro251Ser)	SNV	Uncertain Significance	374659	rs144963732	GRCh37: 5:148420221-148420221 GRCh38: 5:149040658-149040658
14	SH3TC2	NM_024577.4(SH3TC2):c.137A>C (p.Gln46Pro)	SNV	Uncertain Significance	219741	rs146162276	GRCh37: 5:148431719-148431719 GRCh38: 5:149052156-149052156
15	SH3TC2	NM_024577.4(SH3TC2):c.2017G>A (p.Ala673Thr)	SNV	Uncertain Significance	543425	rs201985394	GRCh37: 5:148407278-148407278 GRCh38: 5:149027715-149027715
16	SH3TC2	NM_024577.4(SH3TC2):c.2954A>G (p.Glu985Gly)	SNV	Uncertain Significance	246193	rs575937427	GRCh37: 5:148406234-148406234 GRCh38: 5:149026671-149026671
17	SH3TC2	NM_024577.4(SH3TC2):c.517C>A (p.Leu173Met)	SNV	Uncertain Significance	407269	rs147633804	GRCh37: 5:148422269-148422269 GRCh38: 5:149042706-149042706
18	SH3TC2	NM_024577.4(SH3TC2):c.1830G>A (p.Lys610=)	SNV	Uncertain Significance	351911	rs370025626	GRCh37: 5:148407465-148407465 GRCh38: 5:149027902-149027902
19	SH3TC2	NM_024577.4(SH3TC2):c.3433G>T (p.Ala1145Ser)	SNV	Uncertain Significance	351898	rs141715248	GRCh37: 5:148388459-148388459 GRCh38: 5:149008896-149008896
20	SH3TC2	NM_024577.4(SH3TC2):c.3550A>G (p.Met1184Val)	SNV	Uncertain Significance	157532	rs142451273	GRCh37: 5:148386569-148386569 GRCh38: 5:149007006-149007006
21	SH3TC2, LOC114004390	NM_024577.3(SH3TC2):c.-92C>T	SNV	Uncertain Significance	351924	rs886060200	GRCh37: 5:148442677-148442677 GRCh38: 5:149063114-149063114
22	SH3TC2	NM_024577.4(SH3TC2):c.255C>T (p.Asp85=)	SNV	Uncertain Significance	351923	rs886060199	GRCh37: 5:148427449-148427449 GRCh38: 5:149047886-149047886
23	SH3TC2	NM_024577.4(SH3TC2):c.1889C>T (p.Pro630Leu)	SNV	Uncertain Significance	351909	rs749260578	GRCh37: 5:148407406-148407406 GRCh38: 5:149027843-149027843
24	SH3TC2	NM_024577.4(SH3TC2):c.390C>T (p.Tyr130=)	SNV	Uncertain Significance	351920	rs776623792	GRCh37: 5:148422396-148422396 GRCh38: 5:149042833-149042833
25	SH3TC2	NM_024577.4(SH3TC2):c.505T>C (p.Tyr169His)	SNV	Uncertain Significance	2485	rs80359890	GRCh37: 5:148422281-148422281 GRCh38: 5:149042718-149042718
26	SH3TC2	NM_024577.4(SH3TC2):c.3303G>A (p.Arg1101=)	SNV	Uncertain Significance	351899	rs755006924	GRCh37: 5:148389857-148389857 GRCh38: 5:149010294-149010294
27	SH3TC2	NM_024577.4(SH3TC2):c.280-5C>T	SNV	Uncertain Significance	351922	rs201937366	GRCh37: 5:148424206-148424206 GRCh38: 5:149044643-149044643
28	SH3TC2	NM_024577.4(SH3TC2):c.3600G>A (p.Leu1200=)	SNV	Uncertain Significance	351897	rs886060195	GRCh37: 5:148386519-148386519 GRCh38: 5:149006956-149006956
29	SH3TC2	NM_024577.4(SH3TC2):c.1721A>G (p.Asn574Ser)	SNV	Uncertain Significance	351913	rs201256776	GRCh37: 5:148407574-148407574 GRCh38: 5:149028011-149028011
30	SH3TC2	NM_024577.4(SH3TC2):c.285C>T (p.Leu95=)	SNV	Uncertain Significance	351921	rs574669908	GRCh37: 5:148424196-148424196 GRCh38: 5:149044633-149044633
31	SH3TC2	NM_024577.4(SH3TC2):c.2094C>T (p.Ile698=)	SNV	Uncertain Significance	351907	rs886060196	GRCh37: 5:148407201-148407201 GRCh38: 5:149027638-149027638
32	SH3TC2	NM_024577.4(SH3TC2):c.549C>T (p.Ala183=)	SNV	Uncertain Significance	351918	rs147013935	GRCh37: 5:148421161-148421161 GRCh38: 5:149041598-149041598
33	SH3TC2	NM_024577.4(SH3TC2):c.1245G>A (p.Gly415=)	SNV	Uncertain Significance	241499	rs748870159	GRCh37: 5:148408050-148408050 GRCh38: 5:149028487-149028487
34	SH3TC2	NM_024577.4(SH3TC2):c.1105C>T (p.Arg369Cys)	SNV	Uncertain Significance	351915	rs569974719	GRCh37: 5:148411147-148411147 GRCh38: 5:149031584-149031584
35	SH3TC2	NM_024577.4(SH3TC2):c.2398C>T (p.Leu800Phe)	SNV	Uncertain Significance	351905	rs764616291	GRCh37: 5:148406897-148406897 GRCh38: 5:149027334-149027334
36	SH3TC2	NM_024577.4(SH3TC2):c.956G>T (p.Gly319Val)	SNV	Uncertain Significance	351916	rs753423455	GRCh37: 5:148417903-148417903 GRCh38: 5:149038340-149038340
37	SH3TC2	NM_024577.4(SH3TC2):c.2528G>T (p.Gly843Val)	SNV	Uncertain Significance	476899	rs1463859150	GRCh37: 5:148406767-148406767 GRCh38: 5:149027204-149027204
38	SH3TC2	NM_024577.4(SH3TC2):c.2305G>A (p.Glu769Lys)	SNV	Uncertain Significance	649013	rs764436192	GRCh37: 5:148406990-148406990 GRCh38: 5:149027427-149027427
39	SH3TC2	NM_024577.4(SH3TC2):c.1797G>A (p.Leu599=)	SNV	Uncertain Significance	904949	rs200332172	GRCh37: 5:148407498-148407498 GRCh38: 5:149027935-149027935
40	SH3TC2	NM_024577.4(SH3TC2):c.1922G>T (p.Arg641Leu)	SNV	Uncertain Significance	907496	rs199991156	GRCh37: 5:148407373-148407373 GRCh38: 5:149027810-149027810
41	SH3TC2	NM_024577.4(SH3TC2):c.1002-7G>A	SNV	Uncertain Significance	476879	rs752528409	GRCh37: 5:148411257-148411257 GRCh38: 5:149031694-149031694
42	SH3TC2	NM_024577.4(SH3TC2):c.1403C>T (p.Ala468Val)	SNV	Uncertain Significance	546985	rs6874630	GRCh37: 5:148407892-148407892 GRCh38: 5:149028329-149028329
43	SH3TC2	NM_024577.4(SH3TC2):c.*3993G>C	SNV	Uncertain Significance	904760	rs138512171	GRCh37: 5:148380281-148380281 GRCh38: 5:149000718-149000718
44	SH3TC2	NM_024577.4(SH3TC2):c.*3946C>A	SNV	Uncertain Significance	904761	rs1753583783	GRCh37: 5:148380328-148380328 GRCh38: 5:149000765-149000765
45	SH3TC2	NM_024577.4(SH3TC2):c.*10560T>C	SNV	Uncertain Significance	904888	rs1753464929	GRCh37: 5:148373714-148373714 GRCh38: 5:148994151-148994151
46	SH3TC2	NM_024577.4(SH3TC2):c.*10068C>A	SNV	Uncertain Significance	904947	rs1042787317	GRCh37: 5:148374206-148374206 GRCh38: 5:148994643-148994643
47	SH3TC2	NM_024577.4(SH3TC2):c.*10064C>T	SNV	Uncertain Significance	904948	rs904197605	GRCh37: 5:148374210-148374210 GRCh38: 5:148994647-148994647
48	SH3TC2	NM_024577.4(SH3TC2):c.*9466A>C	SNV	Uncertain Significance	905013	rs980542009	GRCh37: 5:148374808-148374808 GRCh38: 5:148995245-148995245
49	SH3TC2	NM_024577.4(SH3TC2):c.*9445A>G	SNV	Uncertain Significance	905014	rs1422098391	GRCh37: 5:148374829-148374829 GRCh38: 5:148995266-148995266
50	SH3TC2	NM_024577.4(SH3TC2):c.971G>A (p.Arg324Lys)	SNV	Uncertain Significance	905015	rs1754316511	GRCh37: 5:148417888-148417888 GRCh38: 5:149038325-149038325