MNMN
MCID: MNN028
MIFTS: 53

Mononeuropathy of the Median Nerve, Mild (MNMN)

Categories: Genetic diseases, Neuronal diseases
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Aliases & Classifications for Mononeuropathy of the Median Nerve, Mild

MalaCards integrated aliases for Mononeuropathy of the Median Nerve, Mild:

Name: Mononeuropathy of the Median Nerve, Mild 57 12 38 71
Carpal Tunnel Syndrome 57 73 71
Susceptibility to Mononeuropathy of the Median Nerve, Mild 28 5
Mnmn 57 73
Carpal Tunnel Syndrome, Susceptibility to 57
Mononeuropathy of the Median Nerve Mild 73

Characteristics:


Inheritance:

Autosomal dominant 57

OMIM®:

57 (Updated 08-Dec-2022)
Miscellaneous:
allelic disorder to autosomal recessive charcot-marie-tooth disease type 4c


Classifications:



External Ids:

OMIM® 57 613353
MeSH 43 D002349
MedGen 40 C3150596
UMLS 71 C0007286 C3150596

Summaries for Mononeuropathy of the Median Nerve, Mild

UniProtKB/Swiss-Prot: 73 A disease characterized by median nerve mononeuropathy at the wrist. The clinical presentation ranges from a mild phenotype, consistent with carpal tunnel syndrome, to a severe median nerve mononeuropathy at the wrist associated with evidence of a more widespread axonal polyneuropathy. The latter phenotype is similar to that of patients with hereditary neuropathy with liability to pressure palsies.

MalaCards based summary: Mononeuropathy of the Median Nerve, Mild, also known as carpal tunnel syndrome, is related to carpal tunnel syndrome and carpal tunnel syndrome 2, and has symptoms including tremor, back pain and headache. An important gene associated with Mononeuropathy of the Median Nerve, Mild is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2). The drugs Gabapentin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone, and related phenotypes are polyneuropathy and constrictive median neuropathy

More information from OMIM: 613353

Related Diseases for Mononeuropathy of the Median Nerve, Mild

Diseases related to Mononeuropathy of the Median Nerve, Mild via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 12.4
2 carpal tunnel syndrome 2 11.8
3 neuropathy, hereditary, with liability to pressure palsies 11.6
4 amyloidosis, hereditary, transthyretin-related 11.5
5 paresthesia 11.4
6 amyloidosis 11.4
7 peripheral nervous system disease 11.4
8 chromosome 1q21.1 duplication syndrome 11.3
9 radiculopathy 11.3
10 acromegaly 11.3
11 scheie syndrome 11.3
12 temporal arteritis 11.3
13 dialysis-related amyloidosis 11.3
14 mucopolysaccharidosis, type ii 11.3
15 wild type abeta2m amyloidosis 11.3
16 mucolipidosis iii gamma 11.2
17 repetitive motion disorders 11.2
18 nerve compression syndrome 11.2
19 acromicric dysplasia 11.2
20 mucopolysaccharidosis, type vi 11.2
21 mucopolysaccharidosis, type vii 11.2
22 rhizomelic pseudopolyarthritis 11.2
23 localized lichen myxedematosus with monoclonal gammopathy or systemic symptoms 11.2
24 neuropathy 11.1
25 tenosynovitis 11.0
26 polyneuropathy 10.9
27 mononeuropathy 10.9
28 median neuropathy 10.8
29 hypothyroidism 10.8
30 gout 10.8
31 slowed nerve conduction velocity, autosomal dominant 10.8
32 mucopolysaccharidosis-plus syndrome 10.8
33 raynaud disease 10.7
34 synovitis 10.7
35 body mass index quantitative trait locus 1 10.7
36 ulnar neuropathy 10.7
37 diabetic polyneuropathy 10.7
38 neuromuscular disease 10.7
39 lipomatosis, multiple 10.7
40 osteoarthritis 10.6
41 mucopolysaccharidoses 10.6
42 paine syndrome 10.6
43 rapidly involuting congenital hemangioma 10.6
44 complex regional pain syndrome 10.6
45 arthropathy 10.6
46 macrodactyly 10.6
47 microvascular complications of diabetes 1 10.6
48 tendinitis 10.6
49 systemic scleroderma 10.6
50 muscular atrophy 10.6

Comorbidity relations with Mononeuropathy of the Median Nerve, Mild via Phenotypic Disease Network (PDN):


Deficiency Anemia Diabetic Polyneuropathy
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Rheumatoid Arthritis
Transient Cerebral Ischemia Ulnar Nerve Lesion

Graphical network of the top 20 diseases related to Mononeuropathy of the Median Nerve, Mild:



Diseases related to Mononeuropathy of the Median Nerve, Mild

Symptoms & Phenotypes for Mononeuropathy of the Median Nerve, Mild

Human phenotypes related to Mononeuropathy of the Median Nerve, Mild:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 polyneuropathy 30 HP:0001271
2 constrictive median neuropathy 30 HP:0012185
3 peripheral axonal neuropathy 30 HP:0003477
4 mononeuropathy 30 HP:0009831

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Neurologic Peripheral Nervous System:
carpal tunnel syndrome
mononeuropathy of the median nerve
more widespread axonal polyneuropathy may occur
patchy axonal neuropathy

Clinical features from OMIM®:

613353 (Updated 08-Dec-2022)

UMLS symptoms related to Mononeuropathy of the Median Nerve, Mild:


tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; muscle cramp

Drugs & Therapeutics for Mononeuropathy of the Median Nerve, Mild

Drugs for Mononeuropathy of the Median Nerve, Mild (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5
Vancomycin Approved Phase 4 1404-90-6 14969
6
Cefazolin Approved Phase 4 25953-19-9 33255
7
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
12
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
13
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
14
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
15
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
16
Povidone K30 Approved, Experimental, Withdrawn Phase 4 9003-39-8 6917 131751496
17
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
18
Acetaminophen Approved Phase 4 103-90-2 1983
19
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
20
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
21
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
22
Arginine Approved, Investigational, Nutraceutical Phase 4 74-79-3 6322
23
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8 5280382 445354
24
Lipoic acid Approved, Investigational, Nutraceutical Phase 4 1200-22-2 864 6112
25
Cysteine Approved, Nutraceutical Phase 4 52-90-4 594 5862
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
27 Ibuprofen arginine Phase 4
28 Retinol palmitate Phase 4
29 Cyclooxygenase Inhibitors Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Sodium Channel Blockers Phase 4
32 Diuretics, Potassium Sparing Phase 4
33 Alpha-lipoic Acid Phase 4
34 Anti-Anxiety Agents Phase 4
35 Psychotropic Drugs Phase 4
36 Anticonvulsants Phase 4
37 Antibiotics, Antitubercular Phase 4
38 Anti-Bacterial Agents Phase 4
39
Ketorolac Tromethamine Phase 4
40
Methylprednisolone Acetate Phase 4 584547
41 Immunologic Factors Phase 4
42 Protective Agents Phase 4
43 Antineoplastic Agents, Hormonal Phase 4
44 Neuroprotective Agents Phase 4
45 Antiemetics Phase 4
46 Gastrointestinal Agents Phase 4
47 Epinephryl borate Phase 4
48 Pharmaceutical Solutions Phase 4
49
Triamcinolone hexacetonide Phase 4
50
Triamcinolone diacetate Phase 4

Interventional clinical trials:

(show top 50) (show all 353)
# Name Status NCT ID Phase Drugs
1 Pain Reduction and Changes in Upper Limb Function Produced by Over the Counter Oral Ibuprofen Versus the Lack of Treatment, in Carpal Tunnel Syndrome. Unknown status NCT04328805 Phase 4 Ibuprofen tablets
2 Pain Reduction Produced by Physiotherapy, Ibuprofen, and the Absence of Treatment, in Carpal Tunnel Syndrome Unknown status NCT04119739 Phase 4 Ibuprofen
3 A Prospective, Randomized, Double-Blind, Cross-over Study of Lidocaine Patch 1.8% in Patients With Moderate to Severe Pain From Carpal Tunnel Syndrome Unknown status NCT04245371 Phase 4 Lidocaine 1.8%;Placebo
4 Oral Gabapentin Versus Control in the Treatment of Carpal Tunnel Syndrome Unknown status NCT04285281 Phase 4 Gabapentin oral capsules
5 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration: Clinical Randomized Trial Unknown status NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
6 Pain Reduction and Changes in Upper Limb Function Produced by Physiotherapy, Ibuprofen Arginine, Gabapentin and the Absence of Treatment, in Carpal Tunnel Syndrome Unknown status NCT04025203 Phase 4 Ibuprofen Arginine;Gabapentin
7 A Prospective Randomized Controlled Clinical Trial Comparing the Extracorporeal Shock Wave and Local Corticosteroid Injection for Carpal Tunnel Syndrome Completed NCT04767724 Phase 4
8 Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial Completed NCT02140632 Phase 4
9 Randomised, Multicentre, Open Label, Parallel Group Pragmatic Clinical Trial of Local Steroid Injection Versus Night Splinting in Mild to Moderate Carpal Tunnel Syndrome (CTS) Completed NCT02038452 Phase 4 Depo-Medrone
10 The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
11 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
12 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Completed NCT03792945 Phase 4 local injection
13 Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
14 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome (Cts): A Randomized, Placebo-Controlled Trial With Secondary Bayesian Modification Completed NCT00277563 Phase 4
15 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
16 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
17 Onset and Duration of Forearm Nerve Blockade Performed With a Single Distal Injection Versus Sequential Injections at Distal and Proximal Locations Alongside the Nerves: A Blinded Randomized Completed NCT03649763 Phase 4 Lidocaine;Bupivacaine
18 Length of Postoperative Dressing After Mini-open Carpal Tunnel Release: A Randomized Prospective Comparison Completed NCT01310218 Phase 4
19 Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
20 Endoscopic Carpal Tunnel Release, Infection Incidence, and Prophylactic Antibiotics: Indicated or Kick the Habit? Completed NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
21 A Randomized, Controlled Trial Comparing Combination Therapy of Ibuprofen + Acetaminophen Versus Hydrocodone + Acetaminophen for the Treatment of Pain After Carpal Tunnel Surgery Completed NCT01974609 Phase 4 Narcotic;non-narcotic
22 Comparing Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol Administration for Carpal Tunnel Release and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
23 The NOR-CACTUS Trial - A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome Recruiting NCT05306548 Phase 4 Injection, Triamcinolone Hexacetonide
24 The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial Recruiting NCT04460521 Phase 4 N-Acetyl cysteine
25 Comparison of the Efficacy of Different Treatment Methods in Patients With Carpal Tunnel Syndrome Recruiting NCT05475808 Phase 4 Wrist local steroid injection
26 The Therapeutic Effect and Quality of Life After Local Injection of Steroid VS. Glucose 5% for Carpal Tunnel Syndrome : Double-blinded Clinical Trial Recruiting NCT05496764 Phase 4 Dexamethasone;Glucose Injection
27 Randomized Controlled Trial of Ultrasound-guided Steroid Injection Versus Wrist Splint in Patients With Carpal Tunnel Syndrome Recruiting NCT04515966 Phase 4 Methylprednisolone Injection [Solu-Medrol]
28 Exparel and Education to Avoid Opioids After Carpal Tunnel Release Recruiting NCT03867539 Phase 4
29 Satisfaction With Pain Relief After Carpal Tunnel Release Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
30 The Effect of Theraworx Foam on the Cross-sectional Area of the Median Nerve in Patients With Carpal Tunnel Syndrome Withdrawn NCT04017390 Phase 4 Theraworx Foam;Placebo Foam
31 Ultrasound-guided PRP Versus Steroid Injections in Management of Carpal Tunnel Syndrome; a Comparative Study Unknown status NCT04434105 Phase 2, Phase 3 platlet rich plasma (PRP);Triamcinolone Acetonide;Saline
32 Comparison of Local Steroid Injection With Platelet Rich Plasma in the Treatment of Carpal Tunnel Syndrome Unknown status NCT04000932 Phase 3 Local platelet rich plasma (PRP) injection-T-Lab PRP kit;Local steroid injection-Diprospan ®, Schering Plough
33 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
34 Comparison Results of Carpal Tunnel Release Between Standard Incision and Limited Incision Using PSU Retractor: A Randomized Controlled Trial Unknown status NCT01017471 Phase 3
35 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
36 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial. Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
37 Local Steroid Injection in the Treatment of Idiopathic Carpal Tunnel Syndrome: A Randomized Double-blind Placebo-controlled Trial Among Patients Planned for Surgical Treatment Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
38 Gabapentin for Carpal Tunnel Syndrome: A Randomised Controlled Trial Completed NCT00137735 Phase 3 Gabapentin
39 Effect of Preoperative Gabapentine for Carpal Tunnel Syndrome Completed NCT01632215 Phase 3 Gabapentine
40 The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study - A Single Site, Non-inferiority Randomised Control Trial Evaluating Pain After Soft Tissue Corticosteroid Injections With and Without Local Anaesthetic Recruiting NCT04253457 Phase 3 1ml of triamcinolone (40mg/1ml)
41 A Randomized, Double-Blind Study Comparing the Safety and Efficacy of the Lidocaine Patch 5% With Placebo in Patients With Pain From Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
42 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
43 A Phase III, Randomized, Open-label Study to Assess the Safety and Efficacy of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
44 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
45 Instiutional Review Board of Chung Shan Medical University Hospital Unknown status NCT00514462 Phase 1, Phase 2
46 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome: a Preliminary Study. Completed NCT00634699 Phase 1, Phase 2
47 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
48 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome, a Preliminary Study Completed NCT00634738 Phase 1, Phase 2
49 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
50 A Controlled Trial of Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2

Search NIH Clinical Center for Mononeuropathy of the Median Nerve, Mild

Genetic Tests for Mononeuropathy of the Median Nerve, Mild

Genetic tests related to Mononeuropathy of the Median Nerve, Mild:

# Genetic test Affiliating Genes
1 Susceptibility to Mononeuropathy of the Median Nerve, Mild 28 SH3TC2

Anatomical Context for Mononeuropathy of the Median Nerve, Mild

Organs/tissues related to Mononeuropathy of the Median Nerve, Mild:

MalaCards : Skin, Brain, Bone, Spinal Cord, Breast, Thyroid, Cortex

Publications for Mononeuropathy of the Median Nerve, Mild

Articles related to Mononeuropathy of the Median Nerve, Mild:

(show top 50) (show all 9430)
# Title Authors PMID Year
1
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. 62 57 5
20220177 2010
2
Mutational screening of the SH3TC2 gene in Greek patients with suspected demyelinating recessive Charcot-Marie-Tooth disease reveals a varied and unusual phenotypic spectrum. 5
30653784 2019
3
The cerebellar phenotype of Charcot-Marie-Tooth neuropathy type 4C. 5
31346473 2019
4
Screening for SH3TC2 gene mutations in a series of demyelinating recessive Charcot-Marie-Tooth disease (CMT4). 5
27231023 2016
5
Phenotypic variability of CMT4C in a French-Canadian kindred. 5
25737037 2015
6
Clinical exome sequencing for genetic identification of rare Mendelian disorders. 5
25326637 2014
7
Genetic diagnosis of Charcot-Marie-Tooth disease in a population by next-generation sequencing. 5
25025039 2014
8
Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy. 5
23806086 2013
9
The phenotype of Charcot-Marie-Tooth disease type 4C due to SH3TC2 mutations and possible predisposition to an inflammatory neuropathy. 5
19272779 2009
10
Founder SH3TC2 mutations are responsible for a CMT4C French-Canadians cluster. 5
18511281 2008
11
Spine deformities in Charcot-Marie-Tooth 4C caused by SH3TC2 gene mutations. 5
16924012 2006
12
Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. 5
14574644 2003
13
Fibrolipomatous hamartoma with macrodactyly and carpal tunnel syndrome. 62
36411853 2023
14
Shear wave elastography is a valuable tool for diagnosing and grading carpal tunnel syndrome. 62
35920932 2023
15
Repeatability, Reproducibility and Sources of Variability in the Assessment of Backscatter Coefficient and Texture Parameters from High-Frequency Ultrasound Acquisitions in Human Median Nerve. 62
36283940 2023
16
The distance between the distal margin of the flexor retinaculum and the radiocarpal joint as a landmark in CTS surgery: A cadaver study. 62
36183941 2023
17
Repair of severed recurrent thenar branch of median nerve after open carpal tunnel release. 62
36148020 2022
18
Application of an Improved U2-Net Model in Ultrasound Median Neural Image Segmentation. 62
36167742 2022
19
Is the outcome of a revision carpal tunnel release as good as those of a primary release? A matched cohort study. 62
36272920 2022
20
Neuropathic upper extremity pain: A double-crush scenario. 62
36412937 2022
21
Association of Economic Well-Being With Comorbid Conditions in Patients Undergoing Carpal Tunnel Release. 62
34716055 2022
22
Patient Concerns About Wide-Awake Local Anesthesia No Tourniquet (WALANT) Hand Surgery. 62
34774346 2022
23
Deep CTS: a Deep Neural Network for Identification MRI of Carpal Tunnel Syndrome. 62
35661280 2022
24
Comparison of ultrasound-guided pulsed radiofrequency versus steroid injection in the treatment of carpal tunnel syndrome. 62
35129753 2022
25
Contribution of imaging to preoperative work-up for persistent carpal tunnel syndrome. 62
36089215 2022
26
A Quality Collaborative Study of the Concordance of Electrodiagnostic Scores and Clinical Severity in Carpal Tunnel Syndrome. 62
36112828 2022
27
Factors affecting contralateral wrist surgery after one carpal tunnel release in bilateral carpal tunnel syndrome. 62
36150692 2022
28
Understanding carpal tunnel syndrome. 62
36346923 2022
29
Comparison of Distal and Proximal Local Steroid Injection for Carpal Tunnel Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials. 62
36197649 2022
30
Ultrasound-based radiomics in the diagnosis of carpal tunnel syndrome: The influence of regions of interest delineation method on mode. 62
36341718 2022
31
Fibrolipomatous hamartoma of the median nerve in a child with carpal tunnel syndrome: imaging findings and literature review. 62
36418537 2022
32
A 60-Year-Old Woman with Symptoms of Combined Carpal Tunnel Syndrome and Cubital Tunnel Syndrome Due to an Elastofibroma Causing Compression of the Median and Ulnar Nerves. 62
36419329 2022
33
Has the Use of Electrodiagnostic Studies for Carpal Tunnel Syndrome Changed After the 2016 American Academy of Orthopaedic Surgeons Clinical Practice Guideline? 62
36460552 2022
34
[Amyloid arthropathy and the carpal tunnel syndrome: report of a case]. 62
36323556 2022
35
Pseudogout: A Rare Cause of Acute Carpal Tunnel Syndrome and Acute Guyon Canal Syndrome. 62
36425382 2022
36
Clinical Relevance of Ultrasonographic and Electrophysiological Findings of the Median Nerve in Unilateral Carpal Tunnel Syndrome Patients. 62
36428858 2022
37
Incidence of Carpal Tunnel Syndrome after Distal Radius Fracture. 62
36425367 2022
38
Carpal Tunnel Syndrome in the Setting of Ulnar Dysmelia. 62
36425379 2022
39
Impaired median nerve mobility in patients with carpal tunnel syndrome: a systematic review and meta-analysis. 62
36394604 2022
40
Work-relatedness of carpal tunnel syndrome: Systematic review including meta-analysis and GRADE. 62
36340637 2022
41
A preliminary study of radioulnar wrist compression in improving patient-reported outcomes of carpal tunnel syndrome. 62
36352375 2022
42
Carpal tunnel syndrome secondary to tumoral calcinosis: a case report and review of the literature. 62
36348303 2022
43
Ultrasound Findings in Patients with Normal Nerve Conduction despite Clinical Signs and Symptoms Consistent with Carpal Tunnel Syndrome. 62
35998137 2022
44
Carpal tunnel mechanics and its relevance to carpal tunnel syndrome. 62
36442295 2022
45
Digital Skin Ulceration and Acro-Osteolysis: A Rare Presentation of Severe Carpal Tunnel Syndrome. 62
36386731 2022
46
Ultrasound of the Median Nerve in the Surgical Treatment of Severe Carpal Tunnel Syndrome. 62
33487036 2022
47
Complex trigger wrist associated with carpal tunnel syndrome: a case report. 62
36371272 2022
48
A Retrospective Clinical Study of Endoscopic Treatment of Carpal Tunnel Syndrome using the Modified Soft Tissue Release kit. 62
36414546 2022
49
VOLCON: a randomized controlled trial investigating complications and functional outcome of volar plating vs casting of unstable distal radius fractures in patients older than 65 years. 62
36443579 2022
50
Red flags in patients with hereditary transthyretin amyloidosis at diagnosis in a non-endemic area of Spain. 62
36396096 2022

Variations for Mononeuropathy of the Median Nerve, Mild

ClinVar genetic disease variations for Mononeuropathy of the Median Nerve, Mild:

5 (show top 50) (show all 538)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SH3TC2 NM_024577.4(SH3TC2):c.2860C>T (p.Arg954Ter) SNV Pathogenic
Pathogenic
2482 rs80338933 GRCh37: 5:148406435-148406435
GRCh38: 5:149026872-149026872
2 SH3TC2 NM_024577.4(SH3TC2):c.1972C>T (p.Arg658Cys) SNV Likely Pathogenic
21690 rs80338926 GRCh37: 5:148407323-148407323
GRCh38: 5:149027760-149027760
3 SH3TC2 NM_024577.4(SH3TC2):c.3512G>A (p.Arg1171His) SNV Uncertain Significance
952984 rs200728983 GRCh37: 5:148386607-148386607
GRCh38: 5:149007044-149007044
4 SH3TC2 NM_024577.4(SH3TC2):c.1431G>A (p.Glu477=) SNV Uncertain Significance
476884 rs887057321 GRCh37: 5:148407864-148407864
GRCh38: 5:149028301-149028301
5 SH3TC2 NM_024577.4(SH3TC2):c.79A>G (p.Thr27Ala) SNV Uncertain Significance
220296 rs141649676 GRCh37: 5:148431777-148431777
GRCh38: 5:149052214-149052214
6 SH3TC2, LOC114004390 NM_024577.3(SH3TC2):c.-77C>T SNV Uncertain Significance
906669 rs1017906109 GRCh37: 5:148442662-148442662
GRCh38: 5:149063099-149063099
7 SH3TC2 NM_024577.4(SH3TC2):c.3686A>T (p.Asp1229Val) SNV Uncertain Significance
188089 rs146920285 GRCh37: 5:148384455-148384455
GRCh38: 5:149004892-149004892
8 SH3TC2 NM_024577.4(SH3TC2):c.2812C>T (p.His938Tyr) SNV Uncertain Significance
448368 rs144688852 GRCh37: 5:148406483-148406483
GRCh38: 5:149026920-149026920
9 SH3TC2 NM_024577.4(SH3TC2):c.3413G>A (p.Ser1138Asn) SNV Uncertain Significance
407264 rs150805608 GRCh37: 5:148388479-148388479
GRCh38: 5:149008916-149008916
10 SH3TC2 NM_024577.4(SH3TC2):c.2304C>T (p.Leu768=) SNV Uncertain Significance
220505 rs140829706 GRCh37: 5:148406991-148406991
GRCh38: 5:149027428-149027428
11 SH3TC2 NM_024577.4(SH3TC2):c.1767C>T (p.Ser589=) SNV Uncertain Significance
390930 rs139898175 GRCh37: 5:148407528-148407528
GRCh38: 5:149027965-149027965
12 SH3TC2 NM_024577.4(SH3TC2):c.830C>T (p.Thr277Met) SNV Uncertain Significance
543415 rs757969875 GRCh37: 5:148418029-148418029
GRCh38: 5:149038466-149038466
13 SH3TC2 NM_024577.4(SH3TC2):c.751C>T (p.Pro251Ser) SNV Uncertain Significance
374659 rs144963732 GRCh37: 5:148420221-148420221
GRCh38: 5:149040658-149040658
14 SH3TC2 NM_024577.4(SH3TC2):c.137A>C (p.Gln46Pro) SNV Uncertain Significance
219741 rs146162276 GRCh37: 5:148431719-148431719
GRCh38: 5:149052156-149052156
15 SH3TC2 NM_024577.4(SH3TC2):c.2017G>A (p.Ala673Thr) SNV Uncertain Significance
543425 rs201985394 GRCh37: 5:148407278-148407278
GRCh38: 5:149027715-149027715
16 SH3TC2 NM_024577.4(SH3TC2):c.2954A>G (p.Glu985Gly) SNV Uncertain Significance
246193 rs575937427 GRCh37: 5:148406234-148406234
GRCh38: 5:149026671-149026671
17 SH3TC2 NM_024577.4(SH3TC2):c.517C>A (p.Leu173Met) SNV Uncertain Significance
407269 rs147633804 GRCh37: 5:148422269-148422269
GRCh38: 5:149042706-149042706
18 SH3TC2 NM_024577.4(SH3TC2):c.1830G>A (p.Lys610=) SNV Uncertain Significance
351911 rs370025626 GRCh37: 5:148407465-148407465
GRCh38: 5:149027902-149027902
19 SH3TC2 NM_024577.4(SH3TC2):c.3433G>T (p.Ala1145Ser) SNV Uncertain Significance
351898 rs141715248 GRCh37: 5:148388459-148388459
GRCh38: 5:149008896-149008896
20 SH3TC2 NM_024577.4(SH3TC2):c.3550A>G (p.Met1184Val) SNV Uncertain Significance
157532 rs142451273 GRCh37: 5:148386569-148386569
GRCh38: 5:149007006-149007006
21 SH3TC2, LOC114004390 NM_024577.3(SH3TC2):c.-92C>T SNV Uncertain Significance
351924 rs886060200 GRCh37: 5:148442677-148442677
GRCh38: 5:149063114-149063114
22 SH3TC2 NM_024577.4(SH3TC2):c.255C>T (p.Asp85=) SNV Uncertain Significance
351923 rs886060199 GRCh37: 5:148427449-148427449
GRCh38: 5:149047886-149047886
23 SH3TC2 NM_024577.4(SH3TC2):c.1889C>T (p.Pro630Leu) SNV Uncertain Significance
351909 rs749260578 GRCh37: 5:148407406-148407406
GRCh38: 5:149027843-149027843
24 SH3TC2 NM_024577.4(SH3TC2):c.390C>T (p.Tyr130=) SNV Uncertain Significance
351920 rs776623792 GRCh37: 5:148422396-148422396
GRCh38: 5:149042833-149042833
25 SH3TC2 NM_024577.4(SH3TC2):c.505T>C (p.Tyr169His) SNV Uncertain Significance
2485 rs80359890 GRCh37: 5:148422281-148422281
GRCh38: 5:149042718-149042718
26 SH3TC2 NM_024577.4(SH3TC2):c.3303G>A (p.Arg1101=) SNV Uncertain Significance
351899 rs755006924 GRCh37: 5:148389857-148389857
GRCh38: 5:149010294-149010294
27 SH3TC2 NM_024577.4(SH3TC2):c.280-5C>T SNV Uncertain Significance
351922 rs201937366 GRCh37: 5:148424206-148424206
GRCh38: 5:149044643-149044643
28 SH3TC2 NM_024577.4(SH3TC2):c.3600G>A (p.Leu1200=) SNV Uncertain Significance
351897 rs886060195 GRCh37: 5:148386519-148386519
GRCh38: 5:149006956-149006956
29 SH3TC2 NM_024577.4(SH3TC2):c.1721A>G (p.Asn574Ser) SNV Uncertain Significance
351913 rs201256776 GRCh37: 5:148407574-148407574
GRCh38: 5:149028011-149028011
30 SH3TC2 NM_024577.4(SH3TC2):c.285C>T (p.Leu95=) SNV Uncertain Significance
351921 rs574669908 GRCh37: 5:148424196-148424196
GRCh38: 5:149044633-149044633
31 SH3TC2 NM_024577.4(SH3TC2):c.2094C>T (p.Ile698=) SNV Uncertain Significance
351907 rs886060196 GRCh37: 5:148407201-148407201
GRCh38: 5:149027638-149027638
32 SH3TC2 NM_024577.4(SH3TC2):c.549C>T (p.Ala183=) SNV Uncertain Significance
351918 rs147013935 GRCh37: 5:148421161-148421161
GRCh38: 5:149041598-149041598
33 SH3TC2 NM_024577.4(SH3TC2):c.1245G>A (p.Gly415=) SNV Uncertain Significance
241499 rs748870159 GRCh37: 5:148408050-148408050
GRCh38: 5:149028487-149028487
34 SH3TC2 NM_024577.4(SH3TC2):c.1105C>T (p.Arg369Cys) SNV Uncertain Significance
351915 rs569974719 GRCh37: 5:148411147-148411147
GRCh38: 5:149031584-149031584
35 SH3TC2 NM_024577.4(SH3TC2):c.2398C>T (p.Leu800Phe) SNV Uncertain Significance
351905 rs764616291 GRCh37: 5:148406897-148406897
GRCh38: 5:149027334-149027334
36 SH3TC2 NM_024577.4(SH3TC2):c.956G>T (p.Gly319Val) SNV Uncertain Significance
351916 rs753423455 GRCh37: 5:148417903-148417903
GRCh38: 5:149038340-149038340
37 SH3TC2 NM_024577.4(SH3TC2):c.2528G>T (p.Gly843Val) SNV Uncertain Significance
476899 rs1463859150 GRCh37: 5:148406767-148406767
GRCh38: 5:149027204-149027204
38 SH3TC2 NM_024577.4(SH3TC2):c.2305G>A (p.Glu769Lys) SNV Uncertain Significance
649013 rs764436192 GRCh37: 5:148406990-148406990
GRCh38: 5:149027427-149027427
39 SH3TC2 NM_024577.4(SH3TC2):c.1797G>A (p.Leu599=) SNV Uncertain Significance
904949 rs200332172 GRCh37: 5:148407498-148407498
GRCh38: 5:149027935-149027935
40 SH3TC2 NM_024577.4(SH3TC2):c.1922G>T (p.Arg641Leu) SNV Uncertain Significance
907496 rs199991156 GRCh37: 5:148407373-148407373
GRCh38: 5:149027810-149027810
41 SH3TC2 NM_024577.4(SH3TC2):c.1002-7G>A SNV Uncertain Significance
476879 rs752528409 GRCh37: 5:148411257-148411257
GRCh38: 5:149031694-149031694
42 SH3TC2 NM_024577.4(SH3TC2):c.1403C>T (p.Ala468Val) SNV Uncertain Significance
546985 rs6874630 GRCh37: 5:148407892-148407892
GRCh38: 5:149028329-149028329
43 SH3TC2 NM_024577.4(SH3TC2):c.*3993G>C SNV Uncertain Significance
904760 rs138512171 GRCh37: 5:148380281-148380281
GRCh38: 5:149000718-149000718
44 SH3TC2 NM_024577.4(SH3TC2):c.*3946C>A SNV Uncertain Significance
904761 rs1753583783 GRCh37: 5:148380328-148380328
GRCh38: 5:149000765-149000765
45 SH3TC2 NM_024577.4(SH3TC2):c.*10560T>C SNV Uncertain Significance
904888 rs1753464929 GRCh37: 5:148373714-148373714
GRCh38: 5:148994151-148994151
46 SH3TC2 NM_024577.4(SH3TC2):c.*10068C>A SNV Uncertain Significance
904947 rs1042787317 GRCh37: 5:148374206-148374206
GRCh38: 5:148994643-148994643
47 SH3TC2 NM_024577.4(SH3TC2):c.*10064C>T SNV Uncertain Significance
904948 rs904197605 GRCh37: 5:148374210-148374210
GRCh38: 5:148994647-148994647
48 SH3TC2 NM_024577.4(SH3TC2):c.*9466A>C SNV Uncertain Significance
905013 rs980542009 GRCh37: 5:148374808-148374808
GRCh38: 5:148995245-148995245
49 SH3TC2 NM_024577.4(SH3TC2):c.*9445A>G SNV Uncertain Significance
905014 rs1422098391 GRCh37: 5:148374829-148374829
GRCh38: 5:148995266-148995266
50 SH3TC2 NM_024577.4(SH3TC2):c.971G>A (p.Arg324Lys) SNV Uncertain Significance
905015 rs1754316511 GRCh37: 5:148417888-148417888
GRCh38: 5:149038325-149038325

UniProtKB/Swiss-Prot genetic disease variations for Mononeuropathy of the Median Nerve, Mild:

73
# Symbol AA change Variation ID SNP ID
1 SH3TC2 p.Tyr169His VAR_064421 rs80359890

Expression for Mononeuropathy of the Median Nerve, Mild

Search GEO for disease gene expression data for Mononeuropathy of the Median Nerve, Mild.

Pathways for Mononeuropathy of the Median Nerve, Mild

GO Terms for Mononeuropathy of the Median Nerve, Mild

Sources for Mononeuropathy of the Median Nerve, Mild

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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